Industry is a major source of funding for scientific research. There is also a growing concern for how it corrupts researchers faced with conflicts of interest. As such, the debate has focused on whether researchers have maintained their integrity. In this article we draw on both the history of medicine and formal modeling to argue that given methodological diversity and a merit-based system, industry funding can bias a community without corrupting any particular individual. We close by considering a policy solution (...) that may seem to promote unbiased inquiry but that actually exacerbates the problem without additional restrictions. (shrink)

Geoengineering is defined as the ‘deliberate and large-scale intervention in the Earth’s climatic system with the aim of reducing global warming’. The technological proposals for doing this are highly speculative. Research is at an early stage, but there is a strong consensus that technologies would, if realisable, have profound and surprising ramifications. Geoengineering would seem to be an archetype of technology as social experiment, blurring lines that separate research from deployment and scientific knowledge from technological artefacts. Looking into the experimental (...) systems of geoengineering, we can see the negotiation of what is known and unknown. The paper argues that, in renegotiating such systems, we can approach a new mode of governance—collective experimentation. This has important ramifications not just for how we imagine future geoengineering technologies, but also for how we govern geoengineering experiments currently under discussion. (shrink)

Since the late 1980s, the neglect of experiment by philosophers and historians of science has been replaced by a keen interest in the subject. In this volume, a number of prominent philosophers of experiment directly address basic theoretical questions, develop existing philosophical accounts, and offer novel perspectives on the subject, rather than rely exclusively on historical cases of experimental practice. Each essay examines one or more of six interconnected themes that run throughout the collection: the philosophical implications of actively and (...) intentionally interfering with the material world while conducting experiments; issues of interpretation regarding causality; the link between science and technology; the role of theory in experimentation involving material and causal intervention; the impact of modeling and computer simulation on experimentation; and the philosophical implications of the design, operation, and use of scientific instruments. (shrink)

Approaches to the analysis of theory choice in science studies often focus either on objective criteria or subjective values for evaluating theories or on critical experiments for testing theories. In the present article a historical case study in the biomedical sciences is reconstructed, in which experimentation was performed to choose between two competing theories of blood coagulation. Analysis of this case study reveals that experimentation exhibits a particular structure, composed of design, execution, and results, and specific characteristics, consisting (...) of controllability, reproducibility, plasticity, and fecundity. Although this structure and these characteristics are not used to replace objective criteria or subjective values of theory evaluation or to define critical experiments, they are instrumental for analyzing and understanding theory choice. (shrink)

Proponents of political experiments in living, such as Elizabeth Anderson and Ryan Muldoon, often emphasize their potential to generate useful observational data about the relation between social rules and ethically desirable outcomes. This paper highlights another epistemic dimension of political experiments: their potential to transform the cognitive perspectives of participants. I argue that this transformative dimension of experimentation offers an endogenous societal mechanism for increasing perspectival diversity. I explore the implications of this mechanism for institutional design.

The interdisciplinary group of authors featured in this focus issue contribute to conversations at the intersection of anthropology and ethics by exploring ethical self‐making and moral experimentation among faith‐based actors in a range of humanitarian settings. Kari Henquinet describes the genealogies of American evangelical humanitarianism by focusing on the ethical self‐formation of early World Vision leaders. Rachel Schneider and Sara Williams each explore practices by which relatively privileged individuals seek to cultivate virtue by engaging with those on the margins, (...) in poor, urban neighborhoods in South Africa, and through packaged tours in Israel/palestine, respectively. Sarah Tobin describes projects of Islamic self‐making among displaced refugee women in Jordan. Although they examine a wide range of subjects and settings, they explore a common set of themes, two of which I discuss here: moral experimentation, and engagements with suffering, poverty, and inequality. (shrink)

This article provides a material enactment of educational theory to explore how we might do educational theory differently by defamiliarising the familiar. Theory is often assumed to be abstract, located solely in the realm of ideas and separate from practice. However, this view of theory emerges from a set of ontological and epistemological assumptions of separating meaning from matter that are taken to be foundational, when this need not be the case. Drawing upon what variously might be termed materialist, performative (...) or post‐human positions, the article suggests that it is possible to re‐enact theory as a matter‐ing practice—of matter and meaning. The assumption of a separation that divides theory from practice is challenged in this article, which suggests that theory matters by being entangled with the material and that a separation of matter from meaning is an effect. This approach enacts things as matters of concern by contrast with the representation of objects as matters of fact. In this way, educational theory becomes a form of responsible experimentation rather than simply a representation of others. Some implications for education are outlined. (shrink)

Recent scientific advances have indicated that it may be technically feasible to sustain human embryos in vitro beyond 14 days. Research beyond this stage is currently restricted by a guideline known as the 14-day rule. Since the advances in embryo culturing there have been calls to extend the current limit. Much of the current debate concerning an extension has regarded the 14-day rule as a political compromise and has, therefore, focused on policy concerns rather than assessing the philosophical foundations of (...) the limit. While there are relevant political considerations, I maintain that the success of extension arguments will ultimately depend on the strength of the justifications supporting the current 14-day limit. I argue that the strongest and most prevalent justifications for the 14-day rule—an appeal to individuation and neural development—do not provide adequate support for the limit of 14 days. I instead suggest that an alternative justification based on sentience would constitute a more defensible basis for embryo protection and that a consideration of such grounds appears to support an amendment to the current limit, rather than the retention of it. While these conclusions do not establish conclusively that the current limit should be extended; they do suggest that an extension may be warranted and permissible. As such, this paper offers grounds on which a reassessment of the 14-day rule may be justified. (shrink)

The recent proliferation of types and accounts of experimentation in sustainability science still lacks philosophical reflection. The present paper introduces this burgeoning topic to the philosophy of science by identifying key notions and dynamics in sustainability experimentation, by discussing taxonomies of sustainability experimentation and by focusing on barriers to the transfer of evidence. It integrates three topics: the philosophy of experimentation; the sustainability science literature on experimentation; and discussions on values in science coming from the (...) general philosophy of science, the social sciences, and sustainability science. The aim is to improve understanding of how sustainability experimentation has evolved, from a broader picture of the history and philosophy of science, with a specific focus on understanding evidence production and how evidence traveling in and from sustainability experiments can be improved, particularly in the context of complex and pervasive normative commitments of the research. By engaging in these topics, this research is one of the first philosophical accounts of sustainability experimentation, contributing both to the knowledge on specific philosophies of science and to the further development of an evidence-based sustainability science through a better understanding of the barriers to more relevant and usable knowledge. (shrink)

Claude Bernard, the father of scientific physiology, believed that if medicine was to become truly scientiifc, it would have to be based on rigorous and controlled animal experiments. Bernard instituted a paradigm which has shaped physiological practice for most of the twentieth century. ln this paper we examine how Bernards commitment to hypothetico-deductivism and determinism led to (a) his rejection of the theory of evolution; (b) his minima/ization of the role of clinical medicine and epidemiological studies; and (c) his conclusion (...) that experiments on nonhuman animals were, "entirely conclusive for the toxicology and hygiene of man". We examine some negative consequences of Bernardianism for twentieth century medicine, and argue that physio/ogy's continued adherence to Bernardianism has caused it to diverge from the other biological sciences which have become increasingly infused with evolutionary theory. (shrink)

Starting from the works by Aselli on the milky veins and Harvey on the motion of the heart and the circulation of the blood, the practice of vivisection witnessed a resurgence in the early modern period. I discuss some of the most notable cases in the century spanning from Aselli’s work to the investigations of fluid pressure in plants and animals by Stephen Hales. Key figures in my study include Johannes Walaeus, Jean Pecquet, Marcello Malpighi, Reinier de Graaf, Richard Lower, (...) Anton Nuck, and Anton de Heide. Although vivisection dates from antiquity, early modern experimenters expanded the range of practices and epistemic motivations associated with it, displaying considerable technical skills and methodological awareness about the problems associated with the animals being alive and the issue of generalizing results to humans. Many practitioners expressed great discomfort at the suffering of the animals; however, many remained convinced that their investigations were not only indispensable from an epistemic standpoint but also had potential medical applications. Early modern vivisection experiments were both extensive and sophisticated and cannot be ignored in the literature of early modern experimentation or of experimentation on living organisms across time. (shrink)

The objective of this paper is to explore the Buddhist position particularly within the Mahāyāna sect about the use of human embryos which may be either surplus embryos thawedinthe laboratoryorembryosculturedfor researchpurposes.Buddhismdoesnot give prominence to any supreme creation whose plan might be distorted by human intervention with nature. Buddhism postulates the cyclic course of human existence as eternal. There is no starting point to the series of lives lived and obviously there is no end. In the Buddhist thought, there is a (...) belief that every individual had existence prior to the present birth. Following this, the paper made a study of the details of the conception and gestation as found in the Buddhist literature and sources. Buddhism aims to do away with pain. Intention is an intrinsic aspect in Buddhism referred to as sankalpa, which is beyond mere goals and objectives. An action is deemed as good karma because of its intentions. To Buddhism, a selfless action gains significance. (shrink)

This essay focuses on the meaning that the term “experimental” acquires within spiritualism during the second half of the nineteenth century. It builds upon Paul Janet’s notions of “experience” and “experimentation” in psychology, by stressing the role of physiology and pathology in his reflection. Regardless of the role the concept of “experimentalism” took on in Victor Cousin’s psychology, which arguably indicated more an “internal affection” than actual experimentation, in Janet’s spiritualism the term regains its original meaning of empirical (...) verification. Janet highlights the importance of madness to the development of a new psychological paradigm that could reconcile philosophy and medicine, reason and experience, by taking up pathology as a form of natural and indirect experimentation. (shrink)

Nicholas Rescher undertakes a systematic survey of the role and utility of thought experiments in philosophy. After surveying the historical issues, Rescher examines the principles involved, and explains the conditions under which thought experimentation can validly yield instructive results in philosophy.

We argue that the self-experimentation espoused by Roberts as a means of generating new ideas, particularly in the area of mood, may be confounded by the experimental procedure eliciting those affective changes. We further suggest that ideas might be better generated through contact with a broad range of people, rather than in isolation.

Le présent texte a pour objet de discuter les prétentions de l’économie comportementale, notamment la nature des résultats qu’elle revendique. Cette nouvelle branche du savoir s’affiche souvent comme un nouveau paradigme, mais il est aisé de montrer qu’elle ne peut rompre entièrement avec les ambitions interprétatives qui sont traditionnellement celles des sciences sociales. En conséquence, il est faux de penser que l’expérimentation est destinée à remplacer la compréhension, et une mise en perspective historique nous aidera à voir pourquoi.

Le présent texte a pour objet de discuter les prétentions de l’économie comportementale, notamment la nature des résultats qu’elle revendique. Cette nouvelle branche du savoir s’affiche souvent comme un nouveau paradigme, mais il est aisé de montrer qu’elle ne peut rompre entièrement avec les ambitions interprétatives qui sont traditionnellement celles des sciences sociales. En conséquence, il est faux de penser que l’expérimentation est destinée à remplacer la compréhension, et une mise en perspective historique nous aidera à voir pourquoi.

Le présent texte a pour objet de discuter les prétentions de l’économie comportementale, notamment la nature des résultats qu’elle revendique. Cette nouvelle branche du savoir s’affiche souvent comme un nouveau paradigme, mais il est aisé de montrer qu’elle ne peut rompre entièrement avec les ambitions interprétatives qui sont traditionnellement celles des sciences sociales. En conséquence, il est faux de penser que l’expérimentation est destinée à remplacer la compréhension, et une mise en perspective historique nous aidera à voir pourquoi.

Along three measurements at the Large Hadron Collider (LHC), a high energy particle accelerator, we analyze procedures and consequences of exploratory experimentation (EE). While all of these measurements fulfill the requirements of EE: probing new parameter spaces, being void of a target theory and applying a broad range of experimental methods, we identify epistemic differences and suggest a classification of EE. We distinguish classes of EE according to their respective goals: the exploration where an established global theory cannot provide (...) the details of a local phenomenon, exploration of an astonishing discovery and exploration to find a new entity. We find that these classes also differ with respect to the existence of an identifiable target and their impact on the background theory. The characteristics distinguish EE from other kinds of experimentation, even though these different kinds have not yet been systematically studied. The formal rigor and precision of LHC physics facilitates to analyze concept formation in its early state. In particular we emphasize the importance for nil–results for conceptualization and argue that conceptualization can also be achieved from nil–results only. (shrink)

Moral dilemmas can arise from uncertainty, including uncertainty of the real values involved. One interesting example of this is that of experimentation on human embryos and foetuses, If these have a moral stauts similar to that of human persons then there will be server constraitns on what may be done to them. If embryous have a moral status similar to that of other small clusters of cells, then constraints will be motivated largely by consideration for the persons into whom (...) the embryos may develop. If the truth lies somewhere between these two extremes, the embryo having neither the full moral weight of persons, nor a completely negligible moral weight, then different kinds of constraints will be appropriate. On the face of it, in order to know what kinds of experiements, if any, we are morally justified in performing on embryos we have to know what the moral weight of the embryo is. But then an impasse threatens, for it seems implausible that we can settle with certainty the exact moral status of the human embryo. It is the purpose of this paper to show that moral uncertainty need not make rational moral justification impossible. I develop a framework which distinguishes between what is morally right/wrong, and what is morally justified/unjustified, and applies standard decision theoretic tools to the case of moral uncertainties. (This was the first published account of what has subsequently become known as Expected Moral Value Theory. An earlier version of the paper, "A decision theoretic argument against human embryo experimentation", was published in M. Fricke (ed.), Essays in honor of Bob Durrant. (University of Otago Press, 1986) 111-27.). (shrink)

Returning to the famous prologue to the book Difference and Repetition, in which Gilles Deleuze points out that the time is approaching when it would not be possible to write a philosophy book as before, we will try to think about the deleuzian evocation of the need to adopt a new tone and new rules for the exercise philosophical. We believe that resuming this philosopher's appeal would launch us into the heart of deleuzian and deleuze-guattarian conception of philosophy as (...) class='Hi'>experimentation. The author suggesting that a philosophical treatise should sound as much like a kind of detective novel as it does like science fiction. This excursion, we argue, would not only help us in the deleuzian and deleuzo-guattarian understanding of philosophy as experimentation, but would also make it possible to outline some clues about the role of the history of philosophy at the heart of this conception. (shrink)

Government authorities often view the 3Rs of “replace, reduce, refine” popularized by Russell and Burch as both a regulatory principle and a governance principle aimed at reducing the total amount of animal distress in science. They thus expect that the 3Rs should, in time, result in changes in total animal experimentation numbers. Communications by Swiss authorities provide stark examples of this expectation. But the 3Rs do not aim at affecting animal experimentation at the level of total numbers; rather, (...) they focus on study design in the individual case. While the underlying philosophy of the 3Rs indeed included a principle of seeking feasible overall reforms, this notion is completely absent in the 3Rs framework itself. Authorities need to stop treating the 3Rs as a means to reduce total distress and should instead invest resources into developing feasible and effective strategies for transformative governance in animal research. (shrink)

Open peer commentary on the article ““Black Box” Theatre: Second-Order Cybernetics and Naturalism in Rehearsal and Performance” by Tom Scholte. Upshot: Scholte proposes using the theatre as a laboratory for experimenting with ideas in second-order cybernetics, adding to the repertoire of approaches for advancing this way of thinking. Second-order cybernetics, as art, science and craft, raises questions about the forms of experimentation most useful in such a laboratory. Theatre provides an opportunity to “play” with the dynamics of human interactions (...) and relations and possibly demonstrate value in second-order cybernetic thinking. (shrink)

It is sometimes said that simulation can serve as epistemic substitute for experimentation. Such a claim might be suggested by the fast-spreading use of computer simulation to investigate phenomena not accessible to experimentation (in astrophysics, ecology, economics, climatology, etc.). But what does that mean? The paper starts with a clarification of the terms of the issue and then focuses on two powerful arguments for the view that simulation and experimentation are ‘epistemically on a par’. One is based (...) on the claim that, in experimentation, no less than in simulation, it is not the system under study that is manipulated but a system that ‘stands-in’ for it. The other one highlights the pervasive use of models in experimentation. It will be argued that these arguments, as compelling as they might seem, are each based on a mistaken interpretation of experimentation and that, far from simulation and experimentation being epistemically on a par, they do not have the same epistemic function, do not produce the same kind of epistemic results. (shrink)

The paper presents an argument for treating certain types of computer simulation as having the same epistemic status as experimental measurement. While this may seem a rather counterintuitive view it becomes less so when one looks carefully at the role that models play in experimental activity, particularly measurement. I begin by discussing how models function as “measuring instruments” and go on to examine the ways in which simulation can be said to constitute an experimental activity. By focussing on the connections (...) between models and their various functions, simulation and experiment one can begin to see similarities in the practices associated with each type of activity. Establishing the connections between simulation and particular types of modelling strategies and highlighting the ways in which those strategies are essential features of experimentation allows us to clarify the contexts in which we can legitimately call computer simulation a form of experimental measurement. (shrink)

Some important meta-theoretical insights about experimental psychology are integrated into the "conjectures and refutations" framework in order to reinforce a realist's view of scientific methodology. Some issues which may be difficult for the realist's position are discussed. It is argued that there is no need for the evidential observation to mimic the phenomenon of interest; such a mimicry may even be counter-productive. A case is also made that questions about ecological validity are not relevant to the rationale of experimentation.

The thesis of theory-ladenness of observations, in its various guises, is widely considered as either ill-conceived or harmless to the rationality of science. The latter view rests partly on the work of the proponents of New Experimentalism who have argued, among other things, that experimental practices are efficient in guarding against any epistemological threat posed by theory-ladenness. In this paper I show that one can generate a thesis of theory-ladenness for experimental practices from an influential New Experimentalist account. The notion (...) I introduce for this purpose is the concept of ‘theory-driven data reliability judgments’, according to which theories which are sought to be tested with a particular set of data guide reliability judgments about those very same data. I provide various prominent historical examples to show that TDRs are used by scientists to resolve data conflicts. I argue that the rationality of the practices which employ TDRs can be saved if the independent support of the theories driving TDRs is construed in a particular way. (shrink)

William James's 'The Will to Believe" has been criticized for offering untenable arguments in support of belief in unvalidated hypotheses. Although James is no longer accused of sug­ gesting we can create belief ex nihilo, critics con­ tinue to charge that James's defense of belief in what he called the "religious hypothesis" con­ fuses belief with hypothesis adoption and endorses willful persistence in unvalidated beliefs-not, as he claimed, in pursuit of truth, but merely to avoid the emotional stress of abandoning (...) them. I argue that James's position in "The Will to Believe" can be defended pro­ vided we give up thinking of it as ethics of belief and think of it instead as an ethics of self-experimentation. Subjective data (includ­ ing wants, needs, and desires) are relevant to rational consent to participation in research. (shrink)

Mark Rowlands argues that, contrary to the dominant view, a Rawlsian theory of justice can legitimately be applied to animals. One of the implications of doing so, Rowlands argues, is an end to animal experimentation. I will argue, contrary to Rowlands, that under a Rawlsian theory there may be some circumstances where it is justifiable to use animals as experimental test subjects (where the individual animals are benefited by the experiments).

In this paper, I address the issue of to what extent the theory-dominated view of scientific experimentation describes scientific practice. I rely on a time period from the history of High Energy Physics (HEP), which spans from early 1960s to early 1970s. I argue that theory-ladenness of experimentation (TLE), which grounds theory-dominated conception of experimentation is too coarse-grained inasmuch as it prevents us from seeing the correct relationship that exists between theorizing and experimenting in the scientific practice (...) of HEP. I articulate that in order to be able to get a better understanding of scientific practice, a revision needs to be made in the general conception of TLE. I propose that such a revision is possible if we abandon the commitment that experimentation is always driven by theory. I consider what I call “theory-drivenness” of experimentation (TDE) as a form of theory-ladenness, which amounts to the claim that experiments, from their initial design up to their final stage, are carried out under the framework of a prevailing theory for the purpose of providing definite answers to specific questions already posed by the same theory. I argue that electron-proton inelastic scattering experiments in HEP were firstly carried out without having any recourse to a phenomenological model. From here, I claim that these experiments are not theory-laden in the sense implied by TDE. On the other hand, I argue, inelastic scattering experiments are theory-laden due to the fact that the scientists who perform them are committed to background theories of HEP. That is, I admit the validity of TLE as a philosophical claim, but I attribute a weaker status to it as opposed to its general conception. That is, I propose to differentiate TDE from TLE by claiming that TLE does not entail TDE. (shrink)

In this article I explore the possibilities of experimentation as a non-foundational praxis for introducing novel ways of being into existence. Beginning with a discussion, following Bataille, of the excess of any thought, I argue that any action in the world is necessarily uncertain. Using the insights of Derridean deconstruction combined with Badiousian truth procedure I argue that experimentation offers a means for acting from this uncertain position. Experimentation takes advantage of the play and uncertainty of our (...) understanding of the world as a means of moving towards more progressive political positions. Normal 0 false false false EN-IE X-NONE X-NONE /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-parent:""; mso-padding-alt:0cm 5.4pt 0cm 5.4pt; mso-para-margin-top:0cm; mso-para-margin-right:0cm; mso-para-margin-bottom:10.0pt; mso-para-margin-left:0cm; line-height:115%; mso-pagination:widow-orphan; font-size:11.0pt; font-family:"Calibri","sans-serif"; mso-ascii-font-family:Calibri; mso-ascii-theme-font:minor-latin; mso-hansi-font-family:Calibri; mso-hansi-theme-font:minor-latin; mso-bidi-font-family:"Times New Roman"; mso-bidi-theme-font:minor-bidi; mso-fareast-language:EN-US;}. (shrink)