Ted Shotter's founding of the London Medical Group 50 years ago in 1963 had several far reaching implications for medical ethics, as other papers in this issue indicate. Most significant for the joint authors of this short paper was his founding of the quarterly Journal of Medical Ethics in 1975, with Alastair Campbell as its first editor-in-chief. In 1980 Raanan Gillon began his 20-year editorship . Gillon was succeeded in 2001 by Julian Savulescu, followed by John Harris and Soren Holm (...) in 2004, with Julian Savulescu starting his second and current term in 2011. In 2000 an additional special edition of the JME, Medical Humanities , was published, under the founding joint editorship of Martyn Evans and David Greaves. In 2003 Jane Macnaughton succeeded David Greaves as joint editor. Deborah Kirklin, under whose auspices MH became an independent journal, took over in 2008, and she was succeeded in 2013 by Sue Eckstein. This short paper offers reminiscences and reflections from the two journals’ various editors.From the start the JME was committed to clearly expressed reasoned discussion of ethical issues arising from or related to medical practice and research. In particular, both Edward Shotter and Alastair Campbell, each a cleric , were at pains to make clear that the JME was not a religious journal and that it had no sort of partisan axe to grind.Campbell's appointment as founding editor was something of a surprise, as the original intention had been to appoint a medical doctor, who could be expected to know medical practice from the inside. However, in 1972 Campbell, a Joint Secretary of the Edinburgh Medical Group, had published Moral dilemmas in medicine. …. (shrink)

Adolescence signifies a transition from the use of prereproductive to reproductive strategies in the life history of Homo sapiens. Insofar as human generations overlap, events at adolescence, surrounding the onset of puberty, offer a unique glimpse into human adaptation from the point of view of the changing strategies of both parents and offspring. The timing of puberty is an important life history trait that varies between species, but also between and within the sexes in human beings. (...) The onset of puberty marks the beginning of the reproductive life, is affected by previous experience, and serves as a trigger for behavioral change. Surbey (1988, 1990) reported relationships between father absence, heightened levels of childhood stress, and early menarche and considered them within the context of human evolutionary history. Subsequently, similar findings have been reported in a number of human populations and have been interpreted from several evolutionary perspectives. This article discusses the extent to which these and related findings regarding alterations in the timing of human puberty reflect evolved parental or offspring strategies. It entails a consideration of the applicability of the concepts of phenotypic plasticity, nonadaptive genetic variation, and conditional and alternative reproductive strategies in describing the interwoven nature of strategies employed by parent and child in the transition at adolescence. (shrink)

Data on birth order and parent-offspring relations for 1,601 adolescents participating in the National Longitudinal Study of Adolescent Health were used to test hypotheses about the role of adolescent suicidal behavior in parent-offspring conflict. Among adolescents highly dissatisfied with their mothers, the odds that middleborns would make at least one suicide attempt was 23% that of first- and lastborns (p<.001), but their odds of receiving medical treatment for their attempts was 8.5 times greater than the odds for first- (...) and lastborns (p=.032). The results are tentatively interpreted as supporting the hypothesis that adolescents use suicide attempts to leverage investment from their parents. (shrink)

This chapter begins with a brief review of the theory of parent-offspring conflict and considers the role of this conflict in the cognitive development of human infants. It then discusses the evolution of theory of mind — which is taken to have its origins in human evolution — and considers how this human cognitive specialization might have interacted with existing parent-offspring dynamics. How the epigenetic systems of infants might have responded is shown by elaborating upon (...) existing cognitive and behavioural systems, or by canalizing later developing ones earlier into development, in order to recruit higher degrees of parental investment. The merits of this framework is assessed in the context of the development of behaviours considered by some researchers to be indicative of a certain degree of social understanding, namely, gaze-following, pointing, social smiling, and neonatal imitation. The chapter concludes by showing how this proposal makes several longstanding theoretical and methodological difficulties for the field of cognitive development even more vexing. (shrink)

ABSTRACT. Richard Hooker’s (1554-1600) adaptation of classical logos theology is exceptional and indeed quite original for its extended application of the principles of Neoplatonic apophatic theology to the concrete institutional issues of a particular time and place—the aftermath of the Elizabethan Religious Settlement of 1559. Indeed, his sustained effort to explore the underlying connections of urgent political and constitutional concerns with the highest discourse of hidden divine realities—the knitting together of Neoplatonic theology and Reformation politics—is perhaps the defining characteristic of (...) Hooker’s distinctive mode of thought. Hooker’s ontology adheres to a Proclean logic of procession and reversion (processio and redditus) mediated by Aquinas’s formulation of the so-called 'lex divinitatis' whereby the originative principle of law remains simple and self-identical as an Eternal Law while it emanates manifold, derivative and dependent species of law, preeminently in the Natural Law accessible to human reason and Divine Law revealed through the Sacred Oracles of Scripture. For Hooker, therefore, ‘all thinges’—including even the Elizabethan constitution in Church and Commonwealth, are God’s offspring: ‘they are in him as effects in their highest cause, he likewise actuallie is in them, the assistance and influence of his deitie is theire life.’. (shrink)

Lactation constitutes a major focus for research in international health because of its dramatic impact on child survival; evolutionary biology has investigated lactation as an important aspect of parenting strategy, with implications for understanding parent-offspring conflict. These perspectives are brought together in an attempt to develop integrated models for an issue of key international health concern: the duration of exclusive breast-feeding and the timing of weaning. This analysis highlights the relevance of evolutionary theory for practical problems in public health, (...) and it suggests the utility of public health outcomes for addressing evolutionary questions. (shrink)

Emerging reprogenetic technologies may radically change how humans reproduce in the not-so-distant future. One foreseeable consequence of disruptive innovations in the procreative domain is an increase in the reproductive autonomy of intended parents. Regarding the prospective parental liberty of enhancing non-health–related traits of the offspring, one controversy has particularly dominated the literature. Does parents' choice of genetically enhancing the traits of their descendants compromise children's future personal autonomy? In this article, I will analyse the main arguments which posit that (...) reprogenetic enhancement could be at odds with the child's future autonomy. I will argue that these objections are ill-founded. Moreover, I will present other arguments that show that reprogenetic technologies can enhance the autonomy of future children. Autonomy enhancement is a plausible and pro tanto desirable application of emerging reprogenetic technologies. (shrink)

: Several recent studies in science and technology studies (STS), and in the history of science and technology, have highlighted the stochastic and uncontrollable nature of technological trajectory. In this paper I will examine three technologies--the Triode, the numerically controlled (NC) machine tool, and the Internet--each of which reflects a different aspect of technological uncertainty. I will argue that the Triode's seemingly unpredictable evolution is partly caused by limitations in our present historical knowledge about it. The NC machine's mysteriously unpredictable (...) life emerged partly from the unpredictability in the conflict between workers and managers, and partly from historians' blurring the boundary between workers and managers, combining them into one general category--humans--and contrasting humans with machines. Finally, I will show that the Internet's tremendous momentum should not be interpreted as showing technology's autonomous life, since American engineers constantly intervened in its course through public shows and through the negotiation for international standardization procedures. On this basis, I will also critically examine the cultural meaning of autonomous technology including the constructivist discourses of nonhuman agency. (shrink)

Some have objected to the laboratory cloning of human preembryos on the grounds that the procedure would violate the dignity of and respect owed to human preembryos. Others have argued that human cloning ought be permitted if it will predictably benefit, or at least not burden, individuals who are, unlike the human preembryo, clearly entitled to our respect and concern. Taking this latter position, the legal theorist John A. Robertson has argued that, since cloning does not (...) harm anyone who is clearly entitled to our respect and concern, it should be permitted. In particular, the offspring of cloning, he argues, cannot be genuinely harmed by cloning, since they owe their very existence to the cloning procedure. In this paper, I argue that cloning coupled with its related procedures does in fact place the flesh and blood human offspring of cloning at risk of genuine harm. I thus provide a basis for questioning the moral permissibility of cloning and its related technologies without implying that the human preembryo has dignity or is owed respect. (shrink)

We identify the significance and typical requirements of developmental analyses of the microbiome-gut-brain in parents, offspring, and parent-offspring relations, which have particular importance for neurobehavioral outcomes in mammalian species, including humans. We call for a focus on behavioral measures of social-emotional function. Methodological approaches to interpreting relations between the microbiota and behavior are discussed.

The purpose of medical humanities is to improve the delivery of effective health care through a better understanding of disease in society, and in the individual. The interfaces between the science of medicine and the arts, philosophy, sociology and law interpret causes and effects of disease. The field of medical ethics is the most prominent offspring of this wider debate, yet the context of disease in the life of the individual and of society is profound and far-reaching. The influences (...) of medicine on the humanities and vice versa are all around, yet only recently have they been recognised in the wider world of health care. How can you encapsulate the essence of medical humanities and teach it to health professionals? Medical Humanities is designed to fill the need for a clear, well illustrated text that both provides the principles for the individual reader, and encourages discussion. The issues are explored in four main sections. Based on a highly successful seminar, and with contributions from leading writers, thinkers, and teachers, this book provides a comprehensive and authoritative reference for what is becoming a professional requirement in medicine. It will be invaluable for clinicians and students alike. (shrink)

Although norms of premarital sex vary cross-culturally, the sexuality of adolescent girls has been consistently more restricted than that of adolescent boys. Three major theories that attempt to explain restrictions on female premarital sex (FPS) concern male, female, and parental control. These competing theories have not been tested against each other cross-culturally. In this study, we do this using a sample of 128 nonindustrial societies and socioecological predictors capturing extramarital sex, paternal care, female status, sex ratio, parental control over a (...) daughter’s mate choice, residence, and marriage transactions, while also controlling for phylogenetic non-independence across societies. We found that multiple parties benefit from restrictions on FPS. Specifically, FPS is more restricted in societies intolerant of extramarital sex and where men transfer property to their children (male control), as well as where marriages are arranged by parents (parental control). Both paternity uncertainty (partitioned among marital fidelity and paternal investment) and parent–offspring conflict (prompting parents to control their daughter’s sexuality) were identified as possible mechanisms of FPS restrictions. The evidence for female control is ambiguous, mainly because it can be equally well interpreted as both male control and parental control, and because fathers, rather than mothers, are often the primary decision makers about a daughter’s mate choice. Our results also emphasize the importance of social roles, rather than stereotyped sex roles, as a more useful approach to understanding the evolution of FPS restrictions. (shrink)

It is hypothesized that human faces judged to be attractive by people possess two features—averageness and symmetry—that promoted adaptive mate selection in human evolutionary history by way of production of offspring with parasite resistance. Facial composites made by combining individual faces are judged to be attractive, and more attractive than the majority of individual faces. The composites possess both symmetry and averageness of features. Facial averageness may reflect high individual protein heterozygosity and thus an array of proteins (...) to which parasites must adapt. Heterozygosity may be an important defense of long-lived hosts against parasites when it occurs in portions of the genome that do not code for the essential features of complex adaptations. In this case heterozygosity can create a hostile microenvironment for parasites without disrupting adaptation. Facial bilateral symmetry is hypothesized to affect positive beauty judgments because symmetry is a certification of overall phenotypic quality and developmental health, which may be importantly influenced by parasites. Certain secondary sexual traits are influenced by testosterone, a hormone that reduces immunocompetence. Symmetry and size of the secondary sexual traits of the face (e.g., cheek bones) are expected to correlate positively and advertise immunocompetence honestly and therefore to affect positive beauty judgments. Facial attractiveness is predicted to correlate with attractive, nonfacial secondary sexual traits; other predictions from the view that parasite-driven selection led to the evolution of psychological adaptations of human beauty perception are discussed. The view that human physical attractiveness and judgments about human physical attractiveness evolved in the context of parasite-driven selection leads to the hypothesis that both adults and children have a species-typical adaptation to the problem of identifying and favoring healthy individuals and avoiding parasite-susceptible individuals. It is proposed that this adaptation guides human decisions about nepotism and reciprocity in relation to physical attractiveness. (shrink)

This article argues that the creation of artificial offspring could make our lives more meaningful. By ‘artificial offspring’ I mean beings that we construct, with a mix of human and non-human-like qualities. Robotic artificial intelligences are paradigmatic examples of the form. There are two reasons for thinking that the creation of such beings could make our lives more meaningful and valuable. The first is that the existence of a collective afterlife—i.e. a set of human-like lives (...) that continue after we die—is likely to be an important source and sustainer of meaning in our present lives. The second is that the creation of artificial offspring provides a plausible and potentially better pathway to a collective afterlife than the traditional biological pathway. Both of these arguments are defended from a variety of objections and misunderstandings. (shrink)

The evolutionary origin of human pair-bonds is uncertain. One hypothesis, supported by data from forgers, suggests that pair-bonds function to provision mothers and dependent offspring during lactation. Similarly, public health data from large-scale industrial societies indicate that single mothers tend to wean their children earlier than do women living with a mate. Here we examine relations between pair-bond stability, alloparenting, and cross-cultural trends in breastfeeding using data from 58 “traditional” societies in the Standard Cross-Cultural Sample (SCCS). Analyses show (...) that stable conjugal relationships were associated with significantly later weaning among the societies in the SCCS. The relationship between pair-bond stability and age at weaning was not mediated by women’s ability to provision themselves or women’s kin support. Availability of alloparental care was also inversely related to age at weaning, and the association was not significantly reduced after controlling for frequency of divorce. This study indicates that among a woman’s kin relationships, a pair-bond with a child’s father is especially supportive of breastfeeding. These cross-cultural findings are further evidence that human pair-bonds may have evolved to support lactation. (shrink)

Pre-natal exposure to acute maternal trauma or chronic maternal distress can confer increased risk for psychiatric disorders in later life. Acute maternal trauma is the result of unforeseen environmental or personal catastrophes, while chronic maternal distress is associated with anxiety or depression. Animal studies investigating the effects of pre-natal stress have largely used brief stress exposures during pregnancy to identify critical periods of fetal vulnerability, a paradigm which holds face validity to acute maternal trauma in humans. While understanding these effects (...) is undoubtably important, the literature suggests maternal stress in humans is typically chronic and persistent from pre-conception through gestation. In this review, we provide evidence to this effect and suggest a realignment of current animal models to recapitulate this chronicity. We also consider candidate mediators, moderators and mechanisms of maternal distress, and suggest a wider breadth of research is needed, along with the incorporation of advanced -omics technologies, in order to understand the neurodevelopmental etiology of psychiatric risk. (shrink)

The concept of ‘humane healthcare’ cannot and may not be limited to a personal virtue. For elucidating its meaning and making it functional as a critical ethical criterion for healthcare as a social institution, it is necessary to reflect on the social, cultural, and historical conditions in which modern healthcare finds its offspring and its further development. Doing this is the object and aim of social ethics. Social ethics in itself covers a broad area of different approaches. A main (...) division can be made between a liberal and a communitarian approach. This article focuses on the latter and concentrates on one of its representatives, Charles Taylor. The paper starts with two clarifying paragraphs: one about the terms humane and human, a second about the scope of social ethics. Next, because the term humane presupposes a certain view of man, attention will be paid to the lack of consensus in this respect within modernity, using some reflections of Taylor. In his view, resigning in this lack is a threat for one of the main motives behind modernity: the pursuit of a good and meaningful life. In the following section Taylor's analysis is applied to contemporary healthcare, by means of two examples. At the end the question is raised how to promote humane healthcare? In a short and conclusive sketch, three suggestions are offered for further research: scrutiny of goals and meanings within healthcare and culture, the broadening of the concept of autonomy and the upholding of human dignity as an intrinsic and imperative value. (shrink)

This volume by a political scientist has important implications for the philosopher, in particular the ethicist. Schall recognizes the urgency for men to come to grips intelligently and realistically with the issues associated with population control and ecology, but he argues that the central issue at stake is the meaning of man himself. Schall argues that in general in the western philosophical tradition nature is not its own norm but serves a necessary though functional relation to man. Man is the (...) norm of the natural, not vice versa. Man, because of his power of reflective thought and freedom of choice, has been regarded as in some way unique and superior to other beings. In this tradition lower animals and inanimate nature were directly related to man as his natural supports inasmuch as man could know and use them. The world of animals and non-living nature was accorded respect, but this respect was ultimately a respect for man, who, because of his intelligence, could understand this world and improve it. In addition, in this tradition each human being was regarded as something valuable in himself, with a right to life, liberty, and the pursuit of happiness; he was not regarded as a pure function or instrument of a larger whole, the human species, expendable if he lost his functional utility. Finally, in this tradition man was regarded as essentially two-sexed, male and female, with human offspring begotten by a union of a human male and a human female and brought to maturity and nurtured in a human family. Today, Schall notes, all these characteristics thought historically to constitute man as a distinct being in nature are being seriously challenged and brought into question. Joshua Lederberg, Charles Galton Darwin, Julian Huxley, Eugene P. Odum, Lynn White, Jean Rostand, and many other biologists, geneticists, zoologists and others are urging a new view of man, a view that subordinates the individual to the species, the species to the world of nature, a view that radically separates human sexuality from human reproductivity. What results basically is a new image of what constitutes a "good" man. The good man, in this view, is not the person who has achieved moral goodness as a result of moral choices taken personally by him in the companionship of his fellow men but is rather the result of genetic or behavioral control exercised by an elite during the process of his coming to be and growing to maturity. This well-documented work, despite occasional rhetorical overstatements, merits careful consideration by philosophers today.--W. E. M. (shrink)

During human evolutionary history, there were “trade-offs” between expending time and energy on child-rearing and mating, so both men and women evolved conditional mating strategies guided by cues signaling the circumstances. Many short-term matings might be successful for some men; others might try to find and keep a single mate, investing their effort in rearing her offspring. Recent evidence suggests that men with features signaling genetic benefits to offspring should be preferred by women as short-term mates, but (...) there are trade-offs between a mate's genetic fitness and his willingness to help in child-rearing. It is these circumstances and the cues that signal them that underlie the variation in short- and long-term mating strategies between and within the sexes. Key Words: conditional strategies; evolutionary psychology; fluctuating asymmetry; mating; reproductive strategies; sexual selection. (shrink)

The past few years has seen a resurgence in the public interest in space flight and travel. Spurred mainly by the likes of technology billionaires like Elon Musk and Jeff Bezos, the topic poses both unique scientific as well as ethical challenges. This paper looks at the concept of generation ships, conceptual behemoth ships whose goal is to bring a group of human settlers to distant exoplanets. These ships are designed to host multiple generations of people who will be (...) born, live, and die on these ships long before it reaches its destination. This paper takes reproductive ethics as its lens to look at how genetic enhancement interventions can and should be used not only to ensure that future generations of offspring on the ships, and eventual exoplanet colonies, live a minimally good life but that their births are contingent on them living genuinely good and fulfilling lives. The paper makes the further claim that if such a thesis holds, it also does so for human enhancement on Earth. (shrink)

That there is some connection between politics and human nature is a commonplace, but why and in what way they are conjoined is disputed. Aristotle's practice of comparing humans with other animals, and not conceptually divorcing them, is fruitful. By adopting a similar practice an indirect linkage (rather than Aristotle's direct one) between human nature and politics is identified. The strategy is to locate at least one universal aspect of human nature which is non‐political that, nonetheless, carries (...) with it a requirement that universally calls forth a political response. The aspect is reproductive sex and the need to ensure that offspring survive. In humans, the natural fact of paternal uncertainty is dealt with by conventions, but, because of this, these vary (for example, as between matrilineal and patrilineal kinship systems). But what is necessitated amid this variety is a need to establish an authoritative allocation of responsibility for nurture. Politics is the exercise of that authority. However, because of its roots in conventions called forth by human nature, the link is indirect. The conclusion is that contemporary attempts to re‐establish a direct link are bound to be inconclusive. (shrink)

Behavioral ecology, based in the theory of natural selection, predicts that certain behaviors are likely to differ consistently between the sexes in humans as well as other species: aggression, resource striving, information content of sexual signalling. These differences, though of course open to modification by cultural practice, arise because male and female humans, like males and females of other mammal species, typically optimize their reproductive lifetimes through different behaviors: males specializing in mating effort (which has a high fixed cost, and (...) is not offspring-specific), and females in parental effort (which has more linear reproductive returns, and is offspring-specific). The resulting patterns are reviewed. (shrink)

The successes of the human genome project and genomics research programs portend great potential to improve upon health and enhance life. As scientific advancements continue, bioethicists and policy makers deliberate over the social and ethical implications of genetic and genomic technologies and information (ggT/I). The application of ggT/I to human reproduction raises conceptual and moral questions about being human and the links between offspring, parents, and society. Given ggT/I’s ability to significantly affect the biological constitution of (...) humans and future human generations thinking through such issues is fundamental to ethical and policy analysis. By means of a systematic literature review and accompanying content analysis, this paper highlights the dominant ethical concerns raised within recent bioethics discourse over the use of ggT/I for human reproduction. Based on these findings it aso offers a framework through which, and demarcates where, religious perspectives can add value to genethics debates and policy deliberation. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Human Gene TherapyMary Carrington Coutts (bio)On September 14, 1990, researchers at the U.S. National Institutes of Health (NIH) performed the first approved gene therapy procedure on a four-year-old girl named Ashanti DeSilva. Born with a rare genetic disease, severe combined immune deficiency (SCID), Ashanti lacked a healthy immune system and was extremely vulnerable to infection. Children with SCID usually develop overwhelming infections and rarely survive to adulthood; even (...) a common childhood illness like chicken pox is life-threatening. Ashanti led a cloistered existence, avoiding contact with people outside her family, remaining in the sterile environment of her home, and battling frequent illnesses with massive amounts of antibiotics.In Ashanti's gene therapy procedure, her own white blood cells were genetically modified and then infused back into her bloodstream. Laboratory tests show that the therapy has strengthened Ashanti's immune system. She no longer has recurrent colds, has been allowed to attend school, and has been immunized against whooping cough. This gene therapy procedure is not a cure, however. The genetically-treated white blood cells only survive for a few months and must then be replaced, but Ashanti's future is much brighter because of the new therapy (VI, Thompson [The First] 1993).Although this simplified description of Ashanti's gene therapy procedure sounds like a happy ending, it is little more than an optimistic chapter in a long story. The road to the first approved gene therapy procedure was rocky and fraught with controversy. The biology of human gene therapy is very complex, and there are still many techniques that need to be developed and diseases that need to be understood more fully before gene therapy is well established. The public policy debate surrounding the possible use of genetically engineered material in human subjects is equally complex. Major participants in the debate come from the fields of biology, government, law, medicine, philosophy, politics, and religion, each bringing different views to the discussion.In studying the ethics of gene therapy, one should draw a distinction between [End Page 63] therapy on somatic (non-reproductive) cells and germ (reproductive) cells. Only the germ cells carry the genes that will be passed on to the next generation. Reactions to gene therapy have varied widely. Some commentators on gene therapy object to any form of genetic manipulation, no matter how well-intentioned (VI, Rifkin 1983). Another reaction is to allow the use of somatic-cell therapy, but not to approve the use of germ-line therapy, which could have unforeseeable effects on future generations. A different stance is that, with proper regulation and safeguards, germ-line gene therapy is a logical extension of the progress made to date and that it is an ethically acceptable procedure.TechniquesTo date, 43 research protocols have been approved for somatic-cell gene therapy in the United States. The techniques employed in each protocol vary, but in general a virus is used as a "vector" to insert the desired gene into the DNA of the patient's cells, in order to compensate for a defective gene. For Ashanti's gene therapy, this technique involved obtaining white blood cells and introducing properly functioning genes into as many of the cells as possible. The normal genes were delivered through the use of a specially-engineered virus.Although similar techniques are used in germ-line gene therapy, the procedure is more difficult. There are two basic ways to perform germ-line gene therapy: (1) to treat a preimplantation embryo that carries a serious genetic defect before its implantation in the mother, which necessitates the use of in vitro fertilization techniques; or (2) to treat the germ cells (sperm or egg cells) of afflicted adults so that the genetic defects would not be passed on to their offspring, which requires the technical expertise to delete the defective gene and insert a properly functioning replacement. Because of the complexity of the procedures involved and the attendant ethical controversy, germ-line therapy is not currently performed.Candidate Diseases for Gene TherapyAt present, gene therapy is likely to be most successful in treating diseases that are caused by single-gene defects and has been approved for treating diseases such... (shrink)

The debate about the credentials of sociobiology has persisted because scholars have failed to distinguish the varieties of sociobiology and because too little attention has been paid to the details of the arguments that are supposed to support the provocative claims about human social behavior. I seek to remedy both deficiencies. After analysis of the relationships among different kinds of sociobiology and contemporary evolutionary theory, I attempt to show how some of the studies of the behavior of nonhuman animals (...) meet the methodological standards appropriate to evolutionary research. I contend that the efforts of E. O. Wilson, Richard Alexander, Charles Lumsden, and others to generate conclusions about human nature are flawed, both because they apply evolutionary ideas in an unrigorous fashion and because they use dubious assumptions to connect their evolutionary analyses with their conclusions. This contention rests on analyses of many of the major sociobiological proposals about human social behavior, including: differences in sex roles, racial hostility, homosexuality, conflict between parents and adolescent offspring, incest avoidance, the avunculate, alliances in combat, female infanticide, and gene–culture coevolution.Vaulting Ambitionthus seeks to identify what is good in sociobiology, to expose the errors of premature speculations about human nature, and to prepare the way for serious study of the evolution of human social behavior. (shrink)

At a meeting of the American Society for Value Inquiry in Chicago last spring, and again at a conference on biomedical ethics last fall in London, Ontario, David J. Roy, Head of the Institute for Medical Humanities, University of Montreal, described a developing situation in the biomedical technologies about which he and many of his colleagues in the profession share an enormous apprehension. The biomedical sciences have in their possession, in development, and on the drawing boards a technology that has (...) the potential of enabling us to alter much of what has to date been seen as fundamental givens and fixed points of the human situation, from the forms of human reproduction, through the frequency of distribution of various human characteristics, to those very characteristics themselves. His question , in the form of a plea, was this: it is becoming desperately urgent that scientists and technologists in these fields be given guidance about what they are doing; the sense is that what can be done ranges far beyond what should be done, and that the technological imperative (do what technology makes possible) and the epistemological imperative (find a use for what we know) are so strong that, in the absence of a normative consensus of what it is to be human, these sciences and technologies may well have a transforming impact upon a society that is not prepared to control them. When it becomes possible to eliminate the traditional and biological form of human reproduction, with the development of in vitro fertilization and the artificial placenta, shall we? When it becomes possible to eliminate deleterious genes from the human gene pool (or to limit their occurrence to the level of chance mutation), shall we? When it becomes possible to enable parents to select in advance characteristics of their offspring, from sex to hair and eye color, and perhaps even to influence the polygenic determinate and determinable characteristics of race, stature, aggressiveness, intelligence and talent, to the point that we can influence the distribution of propensities and abilities in the population to fit more closely the manpower needs of our society, shall we? Shall we breed astronauts, musicians.. (shrink)

Humans have developed the capacity to approve or disapprove of the behavior of their children and of unrelated individuals. The ability to approve or disapprove transformed social learning into a system of cumulative cultural inheritance, because it increased the reliability of cultural transmission. Moreover, people can transmit their behavioral experiences (regarding what can and cannot be done) to their offspring, thereby avoiding the costs of a laborious, and sometimes dangerous, evaluation of different cultural alternatives. Our thesis is that, during (...) ontogeny, the evaluative communication (approval/disapproval) between parents and offspring is substituted by other evaluative communications among peers, like individuals of the same generation. Each person belongs to a reference social group with individuals that interact more intensively. Humans have developed psychological mechanisms that enable cultural transmission by being receptive to parental advice as well as their reference social group. The selective pressure that promoted these new evaluative interactions arose to facilitate the establishment of efficient cooperative relationships. In short, the social control of behavior is essential to understand human cultural transmission. (shrink)

International uproar followed the recent announcement of the birth of twin girls whose genomes had been edited with a breakthrough DNA editing-technology. This technology, called clustered regularly interspaced short palindrome repeats or CRISPR-Cas9, can alter any DNA, including DNA in embryos, meaning that changes can be passed to the offspring of the person that embryo becomes. Should we use gene editing technologies to change ourselves, our children, and future generations to come? The potential uses of CRISPR-Cas9 and other gene (...) editing technologies are unprecedented in human history. By using these technologies, we eradicate certain dreadful diseases. Altering human DNA, however, raises enormously difficult questions. Some of these questions are about safety: Can these technologies be deployed without posing an unreasonable risk of physical harm to current and future generations? Can all physical risks be adequately assessed, and responsibly managed? But gene editing technologies also raise other moral questions, which touch on deeply held, personal, cultural, and societal values: Might such technologies redefine what it means to be healthy, or normal, or cherished? Might they undermine relationships between parents and children, or exacerbate the gap between the haves and have-nots? The broadest form of this second kind of question is the focus of this book: What might gene editing--and related technologies--mean for human flourishing? In the new essays collected here, an interdisciplinary group of scholars asks age--old questions about the nature and well-being of humans in the context of a revolutionary new biotechnology--one that has the potential to change the genetic make-up of both existing people and future generations. Welcoming readers who study related issues and those not yet familiar with the formal study of bioethics, the authors of these essays open up a conversation about the ethics of gene editing. It is through this conversation that citizens can influence laws and the distribution of funding for science and medicine, that professional leaders can shape understanding and use of gene editing and related technologies by scientists, patients, and practitioners, and that individuals can make decisions about their own lives and the lives of their families. (shrink)

The ArgumentThis article considers three major problems with the concept of genes for human personality traits: uncertainty about what human personality is; what we mean when we say there is a gene “for” a mental attribute; and the complexity of interactions between genes and environment, and among the genes themselves. It then draws on examples from empirical human genetic studies by the author and his colleagues in order to suggest that the concept of genes for human (...) personality traits nevertheless does have some validity, and also that we may be on the brink of discovering genes with major effects on human personality. This possibility, in particular its ethical aspects, has aroused some public concern. It is suggested that confidential information about an individual's genes does not differ in principle from other confidential information about him or her, and that the ability to affect genes and their expression, temporarily or permanently, does not differ ethically from our current ability to affect other aspects of an individual's physical and psychological functioning. Genes for potential offspring, contained in ova and sperm cells, constitute a special case. (shrink)

Prior to August Weismann’s 1889 germ-plasm theory, social reformers believed that humans could inherit the effects of a salubrious environment and, by passing environmentally-induced modifications to their offspring, achieve continuous progress. Weismann’s theory disrupted this logic and caused many to fear that they had little control over human development. As numerous historians have observed, this contributed to the birth of the eugenics movement. However, through an examination of the work of social scientists Lester Frank Ward, Richard T. Ely, (...) Amos Griswold Warner, James Mark Baldwin, Simon Nelson Patten, Alfred Kroeber, Walter Robinson Smith, and Luther Lee Bernard, I demonstrate that Weismann’s ideas also prompted scholars to create of theories of human progress in which the social environment had a central role and biological heredity had a diminished one. Furthermore, in creating a new theory of social progress based on a concept called “social heredity,” the thinkers surveyed in this article separated biological and social thought and asserted the independence of the American social sciences. I argue that this represents an important moment in the maturation of the human sciences, and I suggest that the germ-plasm theory of heredity deserves a larger place in histories of the development of the American social scientific disciplines. (shrink)

Human psychology contains adaptations to deploy aggression as one solution to many distinct adaptive problems. These include expropriating resources, defending against incursions, establishing encroachment-deterring reputations, inflicting costs on rivals, ascending dominance hierarchies, dissuading partner defection, eliminating fitness-draining offspring, and obtaining new mates. Aggression is not a singular strategy. Comprehensive theories must identify the of multiple adaptations for aggression.

Archaeology, of all the human sciences, can dodge this problem the least, and the great virtue of Shennan’s Genes, Memes and Human History is that he confronts it directly. For though humans are now both cultural and ecological beings, it was not always so. Once our hominid ancestors had a social organisation and a material culture roughly equivalent to that of today’s chimpanzees. Chimps are not encultured in the sense that we are encultured: their social life and their (...) ecology does not depend on the accurate and extensive transmission of information from parents to offspring. It falls to archaeology to document and explain the transition from merely social hominids to encultured hominids. Archaeologists cannot escape our dual nature, for they must explain its coming into being. Thus for an evolutionary archaeologist like Shennan, the evolutionary facet of human nature and human history must be geneologically primary. For our enculturation is the product of a continuing evolutionary process grafted onto the top of a pre-existing set of ecological and social relations. (shrink)

The theory of documentality is a way of describing social reality. Developed by Italian philosopher Maurizio Ferraris, it says that the world of social objects is a world of documents, fundamentally. Specifically, it attempts to fill in gaps regarding the existence of objects whose dependence precedes traditional, written documents. Borrowing from Derrida, Ferraris concludes that no part of social reality exists outside of texts, while expanding the notion of texts to include inscriptions as memories in minds. Social reality is constructed (...) by “inscriptions” on documents, the most basic of which can be the inscriptions of memories, ideas, and things like promises and intentions on the matter of human brains. In “Beyond Paper,” Barry Smith and I raise some issues that confront the theory of documentality when electronic documents are involved, specifically problems concerning the distinction between fixed inscriptions and dynamic software, as well as the existence of legal entities that are never inscribed at all (like a common law marriage, that can exist even without any agreement among the parties). Here, I consider briefly how extending our discussion of documentality and electronic media is further complicated by web 3.0, or the emerging realm of documents and processes involved in smart contracts and their offspring and consider some implications for the law arising from this new manner of executing code and weaving new layers of social reality. (shrink)

Artificial gametes, derived from stem cells, have the potential to enable in vitro fertilization of embryos. Currently, artificial gametes are only being generated in laboratory animals; however, considerable efforts are underway to develop artificial gametes using human cell sources. These artificial gametes are being proposed as a means to address infertility through assisted reproductive technologies. Nonetheless, the availability of artificial gametes obtained from adult organisms can potentially expand the possibilities of reproduction. Various groups, such as same-sex couples, post-menopausal women, (...) and deceased donors, could potentially utilize artificial gametes to conceive genetically related offspring. The advent of artificial gametes raises significant bioethical questions. Should all these reproductive scenarios be accepted? How can we delineate the range of future reproductive choices? A normative bioethical framework may be necessary to establish a consensus regarding the use of human artificial gametes. This review aims to present the current state of research on the biological roadmap for generating artificial gametes, while also summarizing proposed approaches to establish a normative framework that delineates ethically acceptable paths for reproduction. (shrink)

Evolutionary theory predicts that humans should avoid incest because of the negative effects incest has on individual reproduction: production of defective offspring. Selection for the avoidance of close-kin mating has apparently resulted in a psychological mechanism that promotes voluntary incest avoidance. Most human societies are thought to have rules regulating incest. If incest is avoided, why are social rules constructed to regulate it? This target article suggests that incest rules do not exist primarily to regulate close-kin mating but (...) to regulate inbreeding between more distant kin and sexual relations between affinal relatives. Three evolutionary hypotheses about cousin marriage and affinal kin mating follow from this suggestion: Rules regulating mating between affinal kin are means of paternity protection. Cousin marriage is regulated because, if it occurs, it can concentrate wealth and power within families to the detriment of the powerful positions of rulers in stratified societies and the relatively equal social statuses of most men in egalitarian societies. Tests using the comparative method on a worldwide sample of 129 societies supported the three hypotheses. Two alternative anthropological hypotheses failed to be supported. (shrink)

Nonhuman primates don’t have formal kinship systems, but genetic relatedness shapes patterns of residence, behavior, mating preferences, and cognition in the primate order. The goal of this article is to provide insight about the ancestral foundations on which the first human kinship systems were built. In order for evolution to favor nepotistic biases in behavior, individuals need to have opportunities to interact with their relatives and to be able to identify them. Both these requirements impose constraints on the evolution (...) of kinship bonds in primate species. For nonhuman primates and many other mammals, maternal care generates close ties between mothers and offspring and among littermates. For species in which mother–offspring bonds extend beyond weaning, associations with the mother also generate familiarity among siblings of different ages. For species with female philopatry, mother–offspring ties provide the foundation for lifelong relationships between mothers and daughters, and dense matrilineal kin networks. However, several factors constrain the development of kinship bonds in nonhuman primates. First, dispersal strategies, which are designed to reduce inbreeding, bias kinship networks in favor of the philopatric sex. Second, hostile relationships between groups mean that kin ties are usually severed when individuals move from one group to another. Third, in species with polygynandrous mating systems, uncertainty about paternity and restricted periods of male reproductive monopoly limit the scope for development of ties among fathers and offspring, paternal siblings, or extended paternal kin networks. In this article, I explore the impact of these factors on the evolution of ancestral human kinship systems. (shrink)

With the recent advancements in scientific comprehension of genetics and the decipherment of complex techniques for editing human genomes, liberal eugenics—eugenic ideal premised on the liberal values of autonomy and pluralism that leaves reproductive choices to parents rather than anachronistic statist authoritarian interventions—has inevitably become a polarising conundrum in contemporary liberal societies as to its utility and destructiveness. Focusing on one species of liberal eugenics—namely, genome editing interventions—I contend that liberal eugenics could be harmful—harm herein construed as that which (...) undermines the salient liberal values of equality, autonomy, and pluralism—since it is itself antithetical to the bases of the liberal society. This contention is based upon three premises: first, that individuals are rather seldom rational decision-makers such that leaving all reproductive choices to the whims of individual parents would be immensely counterproductive to future offspring’s right to open future; second, that liberal eugenics—much like its authoritarian antecedent—could intersect with myriad identities, including race, class, sex, disability, and sexual orientation in ways that might exacerbate social divisions, marginalise different groups, and engender homogeneity; and third, that it undermines individual autonomy of the future person as a member of the liberal community, particularly if their capacities and abilities are tailored to fit parents’ specific life projects and putatively reasonable conceptions of the good. The underscored potential malaises of liberal eugenics should, I argue, be discursively negotiated between parents and the state via the development of robust general laws that regulate heritable genome editing interventions to ensure that the welfare of the future persons is prioritised and that the liberal commitment to autonomy is immune to antiliberal perversions. (shrink)

The principal objective of this article is to develop an overtly theological interpretive lens for assessing the ethics of human germ line genetic modification (GGM). In constructing this lens, I draw upon four selected doctrinal or thematic strands: Incarnation, resurrection, procreative mandate, and sin. In turn, I derive four corresponding moral claims: there is no Christian essentialist understanding of the body, the body cannot be perfected, offspring remain a good of marriage, and sin is a universal human (...) disability. In conclusion, I contend that for Christians there are three possible broad options for assessing the ethics of GGM: refusal, endorsement, and ambivalence. In each, I assess the principal strengths, weaknesses, and limitations of the respective theological themes, moral claims, and options. In addition, for the sake of this inquiry I assume that the technologies at issue are safe, efficacious, and do not entail the destruction of embryos or fetuses. (shrink)

Contrary to chimpanzees and bonobos, humans display long-term exclusive relationships between males and females. Probably all human cultures have some kind of marriage system, apparently designed to protect these exclusive relationships and the resulting offspring in a potentially sexual competitive environment. Different hypotheses about the origin of human pair-bonds are compared and it is shown how they may refer to different phases of human evolution.

Advancements in science and technology have not only brought hope to humankind to produce disease-free offspring, but also offer possibilities to genetically enhance the next generation’s traits and capacities. Human genetic enhancement, however, raises complex ethical questions, such as to what extent should it be allowed? It has been a great challenge for humankind to develop robust ethical guidelines for human genetic enhancement that address both public concerns and needs. We believe that research about public concerns is (...) necessary prior to developing such guidelines, yet the issues have not been thoroughly investigated in many countries, including Malaysia. Since the novel often functions as a medium for the public to express their concerns, this paper explores ethical concerns about human genetic enhancement expressed in four Malay science fiction novels namely Klon, Leksikon Ledang, Transgenesis Bisikan Rimba and Transgenik Sifar. Religion has a strong influence on the worldview of the Malays therefore some concerns such as playing God are obviously religious. Association of the negative image of scientists as well as the private research companies with the research on human genetic enhancement reflects the authors’ concerns about the main motivations for conducting such research and the extent to which such research will benefit society. (shrink)

In a study drawing from both evolutionary biology and the social sciences, evidence and argument is assembled in support of the comprehensive appli- cation of selfish gene theory to the human population. With a focus on genes giving rise to characteristically-human cooperation (“cooperative genes”) in- volving language and theory of mind, one may situate a whole range of pat- terned behaviour—including celibacy and even slavery—otherwise seeming to present insuperable difficulties. Crucially, the behaviour which tends to propa- gate the (...) cooperative genes may be “at cost” to the genes of some who may be party to the cooperation itself. Explanatory insights are provided by Trivers’ parent-offspring conflict theory, Lack’s principle, and Hamilton’s kin selec- tion mechanism. A primary observation is that cooperation using language and theory of mind is itself interdependent with full human conceptualization of a world of objects and of themselves as embodied beings. Human capaci- ties inhering in, or arising out of, the ability to cooperate are also responsible for a vitally important long-term process, the domestication of animals and p- lants. The approach illuminates the difference between animal and human sexual behaviour, and the emergence of kinship systems. Again, recent pat- terns of population growth become much more explicable. It is argued that the gene is the single controlling replicator; the notion of the meme as a sec- ond independent replicator is flawed. (shrink)

Genome editing holds the promise of revolutionizing many fields in which human interventions have hitherto proved to be insufficient to meet major global challenges, like nutrition and environmental protection. However, it is controversial how far this method might also be applied to the human germline with a view to preventing the transmission of serious genetic diseases to offspring. While there is a near-consensus that genome editing, at the present stage of science, should not be applied clinically, it (...) is unclear whether this also extends to clinically oriented research. It is argued that among the arguments against interventions in the human germline there is only one that is sufficiently strong to be practically relevant: The argument that it is doubtful whether the challenge of off-target effects with potentially fatal health consequences can be met. Since nearly all objectives of human germline genome editing can be attained by PGD, there are good grounds for directing clinically oriented research toward the improvement of this alternative method, which has been proven to be without substantial risks and which involves no ethical problems over and above those involved in genome editing. (shrink)

No later than ~500kya the population of Homo sapiens split into three lin¬eages of independently evolving human populations: Sapiens, Neanderthals and Den¬isovans. After several hundred thousands years, they met several times and interbred with low frequency. Evidence of coupling between them is found in fossil records of Neanderthal – Sapiens offspring and Neanderthal – Denisovans offspring. Moreover, the analysis of ancient and present-day population DNA shows that there were several significant gene flows between populations. Many introgressed sequences (...) from Denisovans and Neanderthals were identified in genomes of currently living populations. All these data, according to biological species definition, may in¬dicate that populations of H. sapiens sapiens and two extinct populations H. sapiens neanderthalensis and H. sapiens denisovensis are one species. Ontological transitions from pre-human beings to humans might have happened before the initial splitting of the Homo sapiens population or after the splitting during evolution of H. sapiens sapiens lineage in Africa. If the ensoulment of the first homo occurred in the evolving populations of H. sapiens sapiens, then occasionally mixed couples created relations that functioned as a family, in which children could have matured. (shrink)

If asked to explain why the Golds’ treatment of other colors in Red Rising is wrong, it is tempting to say something like “they are all human beings, and it is wrong to treat humans in this way!” In this essay, I’ll argue that this simple answer is considerably complicated by the fact that the different colors might not be members of the same biological species, and it is in fact unclear whether any of them are the same species (...) as current humans. Explaining why exactly this is so will lead us to an exploration the long-running debate in biology and philosophy over what exactly it means for two organisms to be “members of the same species.” I’ll begin by discussing the biological essentialism of Aristotle and his followers, who held that an individual organism’s species was determined by essence. One can easily imagine that the Golds might find this attractive, since it would suggest that their “superior” mental and physical capacities made them a different (and probably “higher”) species of humanity than the other colors. Unfortunately for Aristotle, this turns out to be inconsistent with Charles Darwin’s account of evolution by natural selection. This development has led many modern biologists and philosophers of biology to conceptualize species not as an abstract “form” that serves to classify organisms, but rather as a concrete collection of organisms relatively close to each other in space and time. In contrast to biological essentialism, this view of “species as concrete individual” might seem to support the Reds’ claim to the “same species” as the Gold, since they are both part of the same overarching society. Next, I’ll consider how we might tell where one species “ends” and another one “begins.” As it turns out, biologists have many ways of answering his question, each of which makes different judgments about the species of Red Rising’s characters. So, for example, the “Biological Species Concept” bases judgements about species membership on the ability to produce fertile offspring. This concept is far from perfect, however, for reasons that Red Rising makes clear: it doesn’t deal clearly with cases where reproduction is possible but very difficult (a Red and a Gold having a child) or for organisms that do not reproduce sexually (such as Pinks). I’ll then explore a few prominent alternatives to BSC, including both genetically and ecologically based species concepts, and consider their consequences for the society of Red Rising. I’ll conclude by advocating for a “pluralism” about species membership, and will suggest that the people of Red Rising (as well as in the real world) should beware of basing arguments for moral or political equality on the all-too-slippery notion of “shared humanity.” Instead, they should focus on the qualities that make the lives of the individuals (regardless of their species) worth caring about, such as their shared desires to avoid suffering and to lead fulfilling, meaningful lives. (shrink)