Antibiotic use triggers evolutionary and ecological responses from bacteria, leading to antibiotic resistance and harmful patient outcomes. Two complementary strategies support long-term antibiotic effectiveness: conservation of existing therapies and production of novel antibiotics. Conservation encompasses infection control, antibiotic stewardship, and other public health interventions to prevent infection, which reduce antibiotic demand. Production of new antibiotics allows physicians to replace existing drugs rendered less effective by resistance.In recent years, physicians and policymakers have raised concerns about the pipeline for new antibiotics, pointing (...) to a decline in the number of antibiotics approved since the 1980s. This trend has been attributed to high research and development costs, low reimbursement for antibiotics, and regulatory standards for review and approval. Professional societies and researchers around the world have called for renewed emphasis on antimicrobial stewardship, while also supporting antibiotic research and development through grants, changes to intellectual property laws to extend market exclusivity periods, and modification of premarket testing regulations to reduce antibiotic development time and expenses. (shrink)

Numerous reports have noted decreasing numbers of antibiotic approvals. To determine the context for this decline, we examined all new molecule entities (NMEs) and new biologic licenses (NBLs) approved by the FDA from 1980–2009, and compared approval rates of the 61 approved antibiotics to trends in other drug classes. We also tracked withdrawals of approved drugs and found more withdrawals for antibiotics than other drug classes. After adjusting for drugs subsequently withdrawn, the record for antibiotic innovation is less dire than (...) previously reported. We also report problems with the quality of the approved antibiotics studied. Future policies providing incentives for new antibiotic development should not be based on simple numerical targets and key provisions should ensure appropriate quality as well as quantity of antibiotic drug innovation. (shrink)

The minimum-uncertainty states for systems with many degrees of freedom are investigated. The limiting situation, relevant to the electromagnetic field, is discussed and it is pointed out that the states that minimize Δp Δq do not tend to the coherent states. These latter, including the vacuum state, are minimum-uncertainty states for the transverse electric and magnetic fields. In an appendix a direct method to obtain the wave functional for the vacuum is presented.

The ontology of ‘powerful qualities’ is gaining an increasing amount of attention in the literature on properties. This is the view that the so-called categorical or qualitative properties are identical with ‘dispositional’ properties. The position is associated with C.B. Martin, John Heil, Galen Strawson and Jonathan Jacobs. Robert Schroer ( 2012 ) has recently mounted a number of criticisms against the powerful qualities view as conceived by these main adherents, and has also advanced his own (radically different) version of (...) the view. In this paper I have three main aims: firstly, I shall defend the ontology from his critique, arguing that his criticisms do not damage the position. Secondly, I shall argue that Schroer’s own version of the view is untenable. Thirdly, the paper shall serve to clear up some conceptual confusions that often bedevil the powerful qualities view. (shrink)

The ontology of ‘powerful qualities’ is gaining an increasing amount of attention in the literature on properties. This is the view that the so-called categorical or qualitative properties are identical with ‘dispositional’ properties. The position is associated with C.B. Martin, John Heil, Galen Strawson and Jonathan Jacobs. Robert Schroer ( 2012 ) has recently mounted a number of criticisms against the powerful qualities view as conceived by these main adherents, and has also advanced his own (radically different) version of (...) the view. In this paper I have three main aims: firstly, I shall defend the ontology from his critique, arguing that his criticisms do not damage the position. Secondly, I shall argue that Schroer’s own version of the view is untenable. Thirdly, the paper shall serve to clear up some conceptual confusions that often bedevil the powerful qualities view. (shrink)

In response to Flamm and Kodish, I argue that our misunderstanding or disagreement is primarily the result of different definitions of power. I also disagree with them and claim that they are indeed using the public’s ethics. Finally, I argue that there is no reason to think that bioethicists cannot have the same sort of influence in the boardroom that they have in the clinic.

Human intentional action, including the design and use of artifacts, involves the prior mental representation of the goal (end) and the means to achieve that goal. This representation is part of the efficient cause of the action, and thus can be used to explain both the action and the achievement of the end. This is intentional teleological explanation. More generally, teleological explanation that depends on the real existence of a representation of the goal (and the means to achieve it) can (...) be called representational teleological explanation. Such explanations in biology can involve both external representations (e.g., ideas in the mind of God) and internal representations (souls, vital powers, entelechies, developmental programs, etc.). However, another type of explanation of intentional action (or any other process) is possible. Given that an action achieving a result occurs, the action can be explained as fulfilling the necessary conditions (means) for that result (end), and, reciprocally, the result explained by the occurrence of those necessary conditions. This is conditional teleological explanation. For organisms, natural selection is often understood metaphorically as the designer, intentionally constructing them for certain ends. Unfortunately, this metaphor is often taken rather too literally, because it has been difficult to conceive of another way to relate natural selection to the process of evolution. I argue that combining a conditional teleological explanation of organisms and of evolution provides such an alternative. This conditional teleology can be grounded in existence or survival. Given that an organism exists, we can explain its existence by the occurrence of the necessary conditions for that existence. This principle of the 'conditions for existence' was introduced by Georges Cuvier in 1800, and provides a valid, conditional teleological method for explaining organismal structure and behavior. From an evolutionary perspective, the conditions for existence are the range of boundary conditions within which the evolutionary process must occur. Moreover, evolutionary change itself can be subjected to conditional teleological explanation, because natural selection theory is primarily a theory about the relation between the conditions for the existence of organisms and the conditions for the existence of traits in populations. I show that failure to distinguish representational from conditional teleological explanation has confused previous attempts to clarify the relation of teleology to biology. (shrink)

_ Source: _Page Count 9 Robert Doran claims that the sublime is all about transcendence transferred from the religious to the aesthetic domain of experience. Taken in this philosophical rather than stylistic sense, it proved crucial for the development of modern subjectivity. Doran traces the issue from Longinus through the decisive reception of Nicolas Boileau, who first distinguished le sublime from le style sublime, on to an extended engagement with Immanuel Kant. In all this he seeks its place in the (...) rise of the modern bourgeois subject. The social-historical connections tend to be a bit overstated, first, with regard to Boileau and the idea of the honnête homme, and especially with the claim that “Burke treats aesthetic concepts as proxies for sociopolitical categories.” It is not fruitful for an understanding of Kant, either. This weakens his powerful argument for the philosophical significance of the sublime in modern thought. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Buddhist-Christian Studies 26 (2006) 213-216 MuseSearchJournalsThis JournalContents[Access article in PDF]Reviewed byJohn Berthrong Boston University School of TheologyDialogues at One Inch Above the Ground: Reclamations of Belief in an Interreligious Age. By James W. Heisig. New York: Crossroad Publishing Company, 2003. 215 pp.Few scholars are better prepared than James W. Heisig to write about the current state of Buddhist-Christian dialogue, and few have written more insightfully about the historical, theological, (...) religious, and spiritual factors that have made Buddhist-Christian dialogue so intriguing for the last four decades. Heisig is the director of the Nanzan Institute, one of the premier institutions in the world dedicated to cultivating dialogue primarily between Christians and Buddhists, but also with people of other traditions and no religious belief at all.The title of the book is taken from the writings of the famous medieval poet Saigyō, who said that he tried to live at "one inch above the ground." Heisig follows Saigyō's advice by focusing many of his articles on themes such as health and ecology rather than abstruse metaphysical discussions of the intricacies of Buddhist and Christian doctrines, although, as one would expect, he shows a deft hand at explaining the philosophical and theological dimensions of living life at one inch above the ground.The opening two chapters on how we can collectively view the current ecological crisis demonstrate Heisig's sure hand at moving between profound meditations on current events and demonstrating how these problems can be even better understood in terms of spiritual and religious insights. Heisig argues that having two eyes, one Buddhist and one Christian, might just help us walk better on the ground, especially a ground that is being harmed on a daily basis by human disregard for the natural environment. His essay on the interpretation of the Buddhist principle of sufficiency is based on the injunction that we should learn to "consider how much is enough." The following essay demonstrates how hard-headed he can be with his call for us not to move from an uncaring contempt for nature to an equally ill-conceived sentimentalization of nature.There are so many insightful and clever features to the essays in the book that it is hard to pick out any one essay for special comment, but one of my favorites, high-lighting [End Page 213] Heisig's rhetorical powers, is "Six Sūtras on Dialogue" (pp. 139–157). This essay demonstrates what a Christian theologian might learn from engaging in interreligious dialogue. Moreover, it even takes the form, as Heisig explains, of the traditional Buddhist sūtra of six teachings on the nature of dialogue. Dialogue, according to Heisig (echoing Alfred North Whitehead), "is an adventure of ideas" (p. 141). The first teaching is "The spirit of interreligious dialogue need not be born of traditions in order to be reborn there" (p. 145). One of the strong points Heisig makes over and over again is that we now live with increasing self-awareness in a religiously pluralistic world. Actually, we always have, though various theological traditions have been adept at either ignoring or rejecting the notion that there could be anything positive about religious pluralism. At its worst, pluralism simply demonstrated the spiritual depravity and turbidity of humankind, and at best, it could simply be ignored as unworthy of serious comment. With the growing social, political, economic, military, and cultural interconnections of the modern world, no one can ignore pluralism. Theologians and religious leaders, in particular, need to think about religious pluralism even if this dialogue is not something that was "born" within their traditional theological discourse.The second teaching is a corroloary of the first: "Dialogue is primarily a minority enterprise that stands free of the obligations of institutional religion" (p. 147). Now, the leaders of institutional religion might dispute this point, but again Heisig is correct in noting that people are going to talk to their neighbors regardless of what they are told to do by worried religious authorities. He makes the... (shrink)

We describe here recent work on the molecular genetics of mitosis in the filamentous fungus Aspergillus nidulans. Aspergillus is one of three simple eukaryotes with powerful genetic systems that have been used to analyze mitosis. The modern molecular biological techniques available with this organism have made it possible to use mutations to identify genes and proteins that play an important role in mitosis. Three Aspergillus genes that affect mitosis are described. One gene, nimA, is specifically expressed late in the cell (...) cycle and codes for a putative protein kinase that induces mitosis, even in cells blocked in S‐phase. The second gene, bimG, codes for a putative phosphatase that interacts functionally with the nimA kinase. The third gene, bimE, codes for a protein that suppresses mitosis during interphase, apparently by keeping nimA turned off. None of these genes appear to be similar to any of the genes affecting mitosis that have been characterized in other eukaryotes, but rather appear to be elements of a system that prevents mitosis from occurring during interphase. (shrink)

Remarkable in the range that it covers, The Possibilities of Sense testifies to an equally remarkable philosopher. In essays on ethics and thephilosophy of religion, on literature and education, the contributors displaynot only the breadth of D.Z. Phillips's work but also its power. This powercomes largely from Ludwig Wittgenstein, whose significance as a moral and religious philosopher rivals his reputation as a philosopher of language.

We investigate the connection between interference and computational power within the operationally defined framework of generalised probabilistic theories. To compare the computational abilities of different theories within this framework we show that any theory satisfying four natural physical principles possess a well-defined oracle model. Indeed, we prove a subroutine theorem for oracles in such theories which is a necessary condition for the oracle model to be well-defined. The four principles are: causality, purification, strong symmetry, and informationally consistent composition. Sorkin has (...) defined a hierarchy of conceivable interference behaviours, where the order in the hierarchy corresponds to the number of paths that have an irreducible interaction in a multi-slit experiment. Given our oracle model, we show that if a classical computer requires at least n queries to solve a learning problem, because fewer queries provide no information about the solution, then the corresponding “no-information” lower bound in theories lying at the kth level of Sorkin’s hierarchy is \. This lower bound leaves open the possibility that quantum oracles are less powerful than general probabilistic oracles, although it is not known whether the lower bound is achievable in general. Hence searches for higher-order interference are not only foundationally motivated, but constitute a search for a computational resource that might have power beyond that offered by quantum computation. (shrink)

In response to powerful criticisms of older arguments, contemporary defenders of the Church’s traditional stance on homosexuality have fashioned a new kind of argument based upon the special relationship God created between the sexes. In this paper we examine two recent incarnations of this kind of argument and show that both fail to demonstrate the inherent immorality of homosexual relationships, and at most demonstrate that homosexual relationships are inferior to heterosexual relationships in certain respects. At the end of the paper (...) we argue that a good God would have reason to make a certain proportion of humanity homosexual in order to unmask sexist myths. In this way homosexuality could itself strengthen, rather than weaken, the special relationship God created between the sexes. (shrink)

Raciolinguistics reveals the central role that language plays in shaping our ideas about race and vice versa. The book brings together a team of leading scholars-working both within and beyond the United States-to share powerful, much-needed research that helps us understand the increasingly vexed relationships between race, ethnicity, and language in our rapidly changing world. Combining the innovative, cutting-edge approaches of race and ethnic studies with fine-grained linguistic analyses, authors cover a wide range of topics including the struggle over the (...) very term "African American," the racialized language education debates within the increasing number of "majority-minority" immigrant communities in the U.S., the dangers of multicultural education in a Europe that is struggling to meet the needs of new migrants, and the sociopolitical and cultural meanings of linguistic styles used in Brazilian favelas, South African townships, Mexican and Puerto Rican barrios in Chicago, and Korean American "cram schools" in New York City, among other sites. Taking into account rapidly changing demographics in the U.S and shifting cultural and media trends across the globe--from Hip Hop cultures, to transnational Mexican popular and street cultures, to Israeli reality TV, to new immigration trends across Africa and Europe--Raciolinguistics shapes the future of scholarship on race, ethnicity, and language. By taking a comparative look across a diverse range of language and literacy contexts, the volume seeks not only to set the research agenda in this burgeoning area of study, but also to help resolve pressing educational and political problems in some of the most contested raciolinguistic contexts in the world. (shrink)

The sense of agency is the perception of willfully causing something to happen. Wegner and Wheatley proposed three prerequisites for SA: temporal contiguity between an action and its effect, congruence between predicted and observed effects, and exclusivity . We investigated how temporal contiguity, congruence, and the order of two human agents’ actions influenced SA on a task where participants rated feelings of self-agency for producing a tone. SA decreased when tone onsets were delayed, supporting contiguity as important, but the order (...) of the agents’ actions also mattered. Relative contiguity was the main determinant of SA, as delayed tones were usually attributed to the most recent action. This was unaffected by contingencies between the two actors’ actions , showing that contiguity has a powerful influence on SA, even during joint action in the presence of other cues. (shrink)

Globalization has increased the need for managers (and future managers) to predict the potential for country corruption. This study examines the relationship between Hofstede''s cultural dimensions and how country corruption is perceived. Power distance, individualism and masculinity were found to explain a significant portion of the variance in perceived corruption. A significant portion of country''s risk, trade flow with U.S.A., foreign investment, and per capita income was explained by perceived corruption.

We propose a criterion to regard a property of a theory (in first or second order logic) as virtuous: the property must have significant mathematical consequences for the theory (or its models). We then rehearse results of Ajtai, Marek, Magidor, H. Friedman and Solovay to argue that for second order logic, ‘categoricity’ has little virtue. For first order logic, categoricity is trivial; but ‘categoricity in power’ has enormous structural consequences for any of the theories satisfying it. The stability hierarchy extends (...) this virtue to other complete theories. The interaction of model theory and traditional mathematics is examined by considering the views of such as Bourbaki, Hrushovski, Kazhdan, and Shelah to flesh out the argument that the main impact of formal methods on mathematics is using formal definability to obtain results in ‘mainstream’ mathematics. Moreover, these methods (e.g., the stability hierarchy) provide an organization for much mathematics which gives specific content to dreams of Bourbaki about the architecture of mathematics. (shrink)

This paper first recapitulates the objections by H.L.A. Hart to the ways in which John Austin’s command model of law obfuscated the importance and the very existence of power-conferring laws. Although those objections are familiar in the world of contemporary legal philosophy, their insightfulness is highlighted here because they contrast so sharply with Hart’s own neglect of power-conferring laws at some key junctures in his theorizing. In the second half of this paper, I ponder a few of the junctures (...) where Hart failed to heed the admonitions which he had so deftly leveled against Austin. (shrink)

This original and compelling book argues that previous studies of John Stuart Mill's work have neglected his egalitarianism and thus seriously misunderstood his views. Morales demonstrates that Mill was fundamentally concerned with how the exercise of unjust or arbitrary power by some individuals over others sabotages the possibility of human well-being and social improvement. Mill therefore believed that 'perfect equality'--more than liberty--was the foundation of democracy and that democracy was a moral ideal for the organization of human life in (...) all of its dimensions. By reinterpreting Mill, Morales also challenges twentieth-century views of liberalism, and addresses its contemporary communitarian and feminist critics. (shrink)

Ethics in business is the most urgent problem facing America today. Now two of the best-selling authors of our time, Kenneth Blanchard and Norman Vincent Peale, join forces to meet this crisis head-on in this vitally important new book. The Power of Ethical Management proves you don't have to cheat to win. It shows today's managers how to bring integrity back to the workplace. It gives hard-hitting, practical, ethical strategies that build profits, productivity, and long-term success. From a straightforward three-step (...) Ethics Check that helps you evaluate any action or decision, to the "Five P's" of ethical behavior that will clarify your purpose and your goals, The Power of Ethical Management gives you an immensely useful set of tools. These can be put to work right away to enhance the performance of your business and to enrich the quality of your life. The Power of Ethical Management is no theoretical treatise Peale and Blanchard speak from their own enormous and unique experience, They reveal the nuts and bolts, practical strategies for ethical decisions that will show you why integrity pays. "So Vince Lombardi was wrong. Winning is not the only thing as headlines and hearings from Wall Street to Washington confirm. Now comes a better game plan from the powerful one-two punch of Ken Blanchard and Norman Vincent Peale in a quickreading new book, The Power of Ethical Management. Peale and Blanchard may be the best thing that has happened to business ethics since Mike Wallace invented 60 Minutes. -- JOHN MACK CARTIER Editor-in-Chief Good Housekeeping. (shrink)

This incisive book deals with the use of the criminal law to enforce morality, in particular sexual morality, a subject of particular interest and importance since the publication of the Wolfenden Report in 1957. Professor Hart first considers John Stuart Mill's famous declaration: "The only purpose for which power can be rightfully exercised over any member of a civilized community is to prevent harm to others." During the last hundred years this doctrine has twice been sharply challenged by two (...) great lawyers: Sir James Fitzjames Stephen, the great Victorian judge and historian of the common law, and Lord Devlin, who both argue that the use of the criminal law to enforce morality is justified. The author examines their arguments in some detail, and sets out to demonstrate that they fail to recognize distinction of vital importance for legal and political theory, and that they espouse a conception of the function of legal punishment that few would now share. (shrink)

John Locke's labor theory of property is one of the seminal ideas of political philosophy and served to establish its author's reputation as one of the leading social and political thinkers of all time. Through it Locke addressed many of his most pressing concerns, and earned a reputation as an outstanding spokesman for political individualism - a reputation that lingers widely despite some partial challenges that have been raised in recent years. In this major new study Matthew Kramer offers (...) an extensive critique of the labor theory and investigates the consequences of its downfall. With incisive analyses of the merits and failings of many aspects of Locke's political thought, Kramer advances a powerful challenge to Locke's image as an individualist. Employing a rigorously philosophical methodology, but remaining aware of the insights generated by historical approaches to Locke, Kramer concludes that Locke's political vision was in fact profoundly communitarian. (shrink)

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We present a one per cent measurement of the cosmic distance scale from the detections of the baryon acoustic oscillations in the clustering of galaxies from the Baryon Oscillation Spectroscopic Survey, which is part of the Sloan Digital Sky Survey III. Our results come from the Data Release 11 sample, containing nearly one million galaxies and covering approximately 8500 square degrees and the redshift range 0.2 < z < 0.7. We also compare these results with those from the publicly released (...) DR9 and DR10 samples. Assuming a concordance Λ cold dark matter cosmological model, the DR11 sample covers a volume of 13 Gpc3 and is the largest region of the Universe ever surveyed at this density. We measure the correlation function and power spectrum, including density-field reconstruction of the BAO feature. The acoustic features are detected at a significance of over 7σ in both the correlation function and power spectrum. Fitting for the position of the acoustic features measures the distance relative to the sound horizon at the drag epoch, rd, which has a value of rd,fid = 149.28 Mpc in our fiducial cosmology. We find DV = at z = 0.32 and DV = at z = 0.57. At 1.0 per cent, this latter measure is the most precise distance constraint ever obtained from a galaxy survey. Separating the clustering along and transverse to the line of sight yields measurements at z = 0.57 of DA = and H =. Our measurements of the distance scale are in good agreement with previous BAO measurements and with the predictions from cosmic microwave background data for a spatially flat CDM model with a cosmological constant. © 2014 The Author Published by Oxford University Press on behalf of the Royal Astronomical Society. (shrink)

This is a new edition of "A Problem in Greek Ethics," originally published in London in 1901 for "private circulation." Part of the project Immortal Literature Series of classic literature, this is a new edition of the classic work published in 1901-not a facsimile reprint. Obvious typographical errors have been carefully corrected and the entire text has been reset and redesigned by Pen House Editions to enhance readability, while respecting the original edition."A Problem in Greek Ethics" is an account of (...) sexuality between men in all its forms, with Greek culture as a backdrop. Perhaps the best description of "A Problem in Greek Ethics" is this one in "Queer Religion" (Praeger, 2012, edited by Donald L. Boisvert and Jay Emerson Johnson, pp. 180-181): "Published at the turn of the century, 'A Problem in Greek Ethics' is a systematic and well-documented exposition of the role of homosexuality in the different historical periods of ancient Greek society. Throughout most of his work, Symonds prefers to use the term 'paiderastia' to 'homosexuality,' the latter a term he only uses in rare instances. Nevertheless, 'paiderastia,' in Symonds's work, amounts to a broad concept of homosexuality rather than to our current concept of pederasty. Whitman and his work are never mentioned by Symonds in 'A Problem in Greek Ethics,' but the conceptual connection had already been made explicit in Walt Whitman: 'A Study' eight years earlier. In the introductory lines to 'A Problem in Greek Ethics,' the reader is alerted that ancient Greece offers a unique example in history of 'a great and highly developed race not only tolerating homosexual passions, but deeming them of spiritual value, and attempting to use them for the benefit of society.' According to Symonds, while homosexual relations were not prominent in the so-called heroic age of Greece, it was nevertheless the love of Achilles for Patroclus, as narrated by Homer, that conferred in a later age of Greek history an almost religious sanction to the martial form of paiderastia. This episode in the Iliad inspired in later generations an ideal of manly love, which he describes as 'a powerful and masculine emotion, in which effeminacy had no part, and which by no means excluded the ordinary sexual feelings.' To which he adds that the tie created by these relationships was 'both more spiritual and more energetic [than] that which bound man to woman.' While Homer knew not about homosexuality, very early in Greek history paiderastia became a national institution giving rise, according to Symonds, to a distinction between a noble, spiritual, form of masculine passion, which he calls "heroic love," and a base and sensual one, which he identifies as 'vulgar love.'"About the Author: John Addington Symonds was born in Bristol, England, in 1840. He was an English poet, an author of several works, and a literary critic. In 1873 he wrote "A Problem in Greek Ethics," which discussed homosexuality between men. He printed ten copies in 1883, before effectively publishing the book in 1901. He was also known for his work on the Renaissance, as well as for his translations and biographies. He wrote "Our Life in the Swiss Highlands" (1891), biographies of Philip Sidney (1886), Ben Jonson (1886) and Michelangelo (1893), several volumes of poetry and essays, and a translation of the "Autobiography of Benvenuto Cellini" (1887). John Addington Symonds died in Rome in 1893. In 1896, Havelock Ellis published, in German, prepared with the collaboration of Dr. Hans Kurella, "Das konträre Geschlechtsgefühl" (Leipzig, by Georg H. Wigand's Verlag), later revised and published by Ellis as "Sexual Inversion"-the first medical text in English about homosexuality, which he had co-authored with Symonds, and which would become a part of Ellis's six-volume "Studies in the Psychology of Sex.". (shrink)

In lieu of an abstract, here is a brief excerpt of the content:John P. Sisk DOCTOR JOHNSON KICKS A STONE Readers OF Boswell's Life ofJohnson will remember the great Doctor's refutation of Bishop Berkeley's idealism. He and Boswell had just come out of a church in Harwich and were discussing the Bishop's "ingenious sophistry to prove the nonexistence of matter." Boswell observed "that though we are satisfied his doctrine is not true, it is impossible to refute it." To mis (...) Johnson responded, "striking his foot with mighty force against a large stone, till he rebounded from it, T refute it thus.'" For Boswell diis was an argument from first principles diat are as fundamental to metaphysics as axioms are to mathematics. To use Johnson's own phrase, it is an argument based on "the experience of mankind" — the ground upon which he confidendy stood when he expressed his disapproval of such other phUosophical contemporaries as Hume, Voltaire, and Rousseau (the latter "a rascal who ought to be hunted out of society"). Or as WalterJackson Bate puts it in TheAchievement ofSamuelJohnson, the first principle ofhis thinking was "To go back to the living and concrete nature of experience."1 Boswell thought Johnson a philosopher, though he admits in a famous passage that his table manners might have suggested otherwise. Apparently G. K. Chesterton thought he had some claim to the term, for he called Johnson's novel Rasselas "a sort of philosophical satire on philosophy." Most likelyJohnson thought ofhimselfas among many other things a philosopher: the humanities had not yet setded snugly into dieir modern compartments. Now, of course, any undergraduate student of philosophy is willing to believe that Johnson's argument against Berkeley isn't worth much (he may be no less willing to believe that the Bishop's argument isn't worth much eitiier). He may also know that in the perspective of die modern physicist Johnson's stone was not as solid as Johnson thought it was — though it is likely he would have thought diis information 65 66Philosophy and Literature no more relevant to die argument dian Thaïes' belief diat all diings are made of water or Pydiagoras' diat all diings are numbers. The important thing was whether a drinker violated die experience of mankind. When the Scotchman Lord Hunderland praised the ancient philosophers for the candor and good humor widi which they disputed with one anotherJohnson would have none of it: "They disputed with good humour upon dieir fanciful dieories," he said, "because diey were not interested in the truth of them." It is not hard to imagine the Doctor's reaction to our own fanciful theories in philosophy, linguistics, and literary criticism. Suppose him at the Mitre Tavern for an evening's defense of die experience of mankind against die ingenious sophistries of a company made up ofJacques Derrida, Geoffrey H. Hartman, Stanley Fish, Michel Foucault, Paul de Man, and Jacques Lacan — the lot of them variously committed to the belief diat the proper job of philosophy is not the pursuit of the truth but the pursuit of die trudi about die pursuit of die truth. Johnson eyes die group warily, expecting the worst. There are too many Frenchmen present, and as he made clear at supper one July evening in the Turk's Head coffee house, French writers are superficial "because they are not scholars, and so proceed upon the mere power of dieir own minds." Nevertheless, the assembled gendemen present their positions: we are all prisoners ofthe total epistemological environment of our age, our episteme; locked linguistically into interpretive communities, we cannot know die text in itself; die proper function of the critic is creative free play, the text being merely a convenient occasion; language, being self-referential, cannot reveal a subject; human agency is a flattering but deceptive myth; transcendent systems of thought are impossible; if literature touches reality anywhere we cannot know it. MeanwhileJohnson, than whom no man ever had "a more ardent love of literature, or a higher respect for it," is in high dudgeon, kicking figurative stones right and left, no real ones being available inside the Mitre. His adversaries observe him with indulgent good humor, amused but not impressed with this crude bourgeois display, having... (shrink)

Adam Lucas has written another excellent book on medieval history and technology. His approach follows in many ways those of John Langdon and Richard Holt, whose influence he graciously acknowledges. Lucas also continues their challenge to older theories about water-powered mills. What his study adds to theirs is a considerable additional number of medieval monastic and ecclesiastical communities and their mills, most of these located in parts of England much less studied earlier. Thus, he adds considerably to our overall (...) knowledge of milling resources available in England after Domesday and the varied costs of using water- and wind-powered mills. There is much that is good, useful, and innovative in this study.Lucas argues that the conclusions of Marc Bloch’s 1935 article on the advent and triumph of the medieval water mill as a tool of seigneurial oppression cannot be wholly sustained for all of Europe; in many places, including in parts of England and in the holdings of particular r .. (shrink)

Taking perceptual experience to consist in a relation of acquaintance with the sensible qualities, I argue that the state of being acquainted with a sensible quality is intrinsically a form of knowledge, and not merely a means to more familiar kinds of knowledge, such as propositional or dispositional knowledge. We should accept the epistemic claim for its explanatory power and theoretical usefulness. That acquaintance is knowledge best explains the intuitive epistemic appeal of ‘Edenic’ counterfactuals involving unmediated perceptual contact with reality (...) (cf. Chalmers, in: Gendler, Hawthorne (eds) Perceptual experience, Oxford University Press, 2006). It explains the elusiveness of knowledge gained through new acquaintances. It coheres with the knowledge-like functional role of acquaintance in the special context of evaluative beliefs and evaluative reasoning, where the objects of acquaintance serve as evidence and inferential basis. And, finally, taking acquaintance to be knowledge is theoretically fruitful: it helps vindicate claims about the relationship between knowledge and concern for others we already find intuitive or outright accept. After developing a novel case for the epistemic claim, I respond to two familiar objections against it: namely, (1) that there are no pre-propositional, pre-conceptual cases of perceptual experience that remain epistemically relevant (Sellars in Empiricism and the philosophy of mind, Routledge, 1968, McDowell, in: Lindgard (ed) John McDowell: Experience, norm, and nature, Blackwell, 2008); and (2) that the category of knowledge appears gerrymandered once we add ‘object’ knowledge to the epistemological mix (Farkas, in: Knowles, Raleigh (eds), Acquaintance: new essays, Oxford University Press, 2019). (shrink)

Abstract:This article puts forth the thesis that the contractualist account of moral justification affords a powerful reply in business contexts to the question why a business person should put ethics above immediate business interests. A brief survey of traditional theories of business ethics and their approaches to moral motivation is presented. These approaches are criticized. A contractualist conception of ethics in the business world is developed, based on the work of John Rawls and Thomas Scanlon. The desire to justify (...) our choices in terms that others can be reasonably expected to accept, or at least in terms that others cannot reasonably reject, is identified and differentiated from other accounts of motivation. It is this desire that constitutes the core motive to be moral in business on the contractualist conception. Implications of this contractualist conception for the theory and practice of business ethics are then discussed. (shrink)

Towards the end of Percy Bysshe Shelley’s fragment ‘The Triumph of Life’ there are some famous lines which raise most of the questions that will concern me in this essay. Never mind, for the moment, the context: the lines I have in mind are these: “I rose; and, bending at her sweet command, Touched with faint lips the cup she raised, And suddenly my brain became as sand “Where the first wave had more than half erased The track of deer (...) on desert Labrador, Whilst the fierce wolf from which they fled amazed “Leaves his stamp visibly upon the shore Until the second bursts—so on my sight Burst a new Vision never seen before.—1[…]Two kinds of things are happening here which I want to point out. The first is that even as the poem is attempting to represent the mind as passive and the experience of the mind as an empty succession of events, it is also making a quite contrary attempt to represent the mind as active and the succession as a structure. The lines dramatise how a play of mental events, as they are represented in language, may be reprocessed in such a way that some of them come to be classified as interruptions or breaks in the otherwise meaningful sequence composed by the others. As my first paraphrase suggested, it seems to make sense to recast Shelley’s narrative into the story of deer chased by a wolf, a story which is then interrupted by the wave which bursts on the shore and which threatens the coherence of the story by threatening to efface all sin that the deer have passed across the beach, have crossed the mind. 1. Percy Bysshe Shelley, ‘The Triumph of Life,’ in Shelley’s Poetry and Prose, ed. Donald H. Reiman and Sharon B. Powers , II. 403-11. The most illuminating reading of these lines is Paul de Man’s in The Rhetoric of Romanticism , pp. 99-100. John Barrell is professor of English at the University of Sussex and author of a number of books on literature and the visual arts, most recently Poetry, Language and Politics . The Infection of Thomas De Quincey and The Birth of Pandora will be published next year. (shrink)

This book offers a definitive and wide-ranging overview of developments in behavioral finance over the past ten years. In 1993, the first volume provided the standard reference to this new approach in finance--an approach that, as editor Richard Thaler put it, "entertains the possibility that some of the agents in the economy behave less than fully rationally some of the time." Much has changed since then. Not least, the bursting of the Internet bubble and the subsequent market decline further demonstrated (...) that financial markets often fail to behave as they would if trading were truly dominated by the fully rational investors who populate financial theories. Behavioral finance has made an indelible mark on areas from asset pricing to individual investor behavior to corporate finance, and continues to see exciting empirical and theoretical advances. Advances in Behavioral Finance, Volume II constitutes the essential new resource in the field. It presents twenty recent papers by leading specialists that illustrate the abiding power of behavioral finance--of how specific departures from fully rational decision making by individual market agents can provide explanations of otherwise puzzling market phenomena. As with the first volume, it reaches beyond the world of finance to suggest, powerfully, the importance of pursuing behavioral approaches to other areas of economic life. The contributors are Brad M. Barber, Nicholas Barberis, Shlomo Benartzi, John Y. Campbell, Emil M. Dabora, Daniel Kent, François Degeorge, Kenneth A. Froot, J. B. Heaton, David Hirshleifer, Harrison Hong, Ming Huang, Narasimhan Jegadeesh, Josef Lakonishok, Owen A. Lamont, Roni Michaely, Terrance Odean, Jayendu Patel, Tano Santos, Andrei Shleifer, Robert J. Shiller, Jeremy C. Stein, Avanidhar Subrahmanyam, Richard H. Thaler, Sheridan Titman, Robert W. Vishny, Kent L. Womack, and Richard Zeckhauser. (shrink)

Scientists and historians have often presumed that the divide between biochemistry and molecular biology is fundamentally epistemological.100 The historiography of molecular biology as promulgated by Max Delbrück's phage disciples similarly emphasizes inherent differences between the archaic tradition of biochemistry and the approach of phage geneticists, the ur molecular biologists. A historical analysis of the development of both disciplines at Berkeley mitigates against accepting predestined differences, and underscores the similarities between the postwar development of biochemistry and the emergence of molecular biology (...) as a university discipline. Stanley's image of postwar biochemistry, with its focus on viruses as key experimental systems, and its preference for following macromolecular structure over metabolism pathways, traced the outline of molecular biology in 1950.Changes in the postwar political economy of research universities enabled the proliferation of disciplines such as microbiology, biochemistry, biophysics, immunology, and molecular biology in universities rather than in medical schools and agricultural colleges. These disciplines were predominantly concerned with investigating life at the subcellular level-research that during the 1930s had often entailed collaboration with physicists and chemists. The interdisciplinary efforts of the 1930s (many fostered by the Rockefeller Foundation) yielded a host of new tools and reagents that were standardized and mass-produced for laboratories after World War II. This commercial infrastructure enabled “basic” researchers in biochemistry and molecular biology in the 1950s and 1960s to become more independent from physics and chemistry (although they were practicing a physicochemical biology), as well as from the agricultural and medical schools that had previously housed or sponsored such research. In turn, the disciplines increasingly required their practitioners to have specialized graduate training, rather than admitting interlopers from the physical sciences.These general transitions toward greater autonomy for biochemistry and allied disciplines should not mask the important particularities of these developments on each campus. At the University of Caliornia at Berkeley, agriculture had provided, with medicine, significant sponsorship for biochemistry. The proximity of Lawrence and his cyclotrons supported the early development of Berkeley as a center for the biological uses of radioisotopes, particularly in studies of metabolism and photosynthesis. Stanley arrived to establish his department and virus institute before large-scale federal funding of biomedical research was in place, and he courted the state of California for substantial backing by promising both national prominence in the life sciences and virus research pertinent to agriculture and public health. Stanley's venture benefited significantly from the expansion of California's economy after World War II, and his mobilization against viral diseases resonated with the concerns of the Cold War, which fueled the state's rapid growth. The scientific prominence of contemporary developments at Caltech and Stanford invites the historical examination of the significance of postwar biochemistry and molecular biology within the political and cultural economy of the Golden State.In 1950, Stanley presented a persuasive picture of the power of biochemistry to refurbish life science at Berkeley while answering fundamental questions about life and infection. In the words of one Rockefeller Foundation officer,There seems little doubt in [my] mind that as a personality Stanley will be well able to dominate the other personalities on the Berkeley campus and will be able to drive his dream through to completion, which, incidentally, leaves Dr. Hubert [sic] Evans and the whole ineffective Life Sciences building in the somewhat peculiar position of being by-passed by much of the truly modern biochemistry and biophysics research that will be carried out at Berkeley. Furthermore, it seems likely that Dr. S's show will throw Dr. John Lawrence's Biophysics Department strongly in the shade both figuratively and literally, but should make the University of California pre-eminent not only in physics but in biochemistry as well.101Stanley, Sproul, Weaver, and this officer (William Loomis) all testified to a perceptible postwar opportunity to capitalize on public support for biological research that relied on the technologies from physics and chemistry without being captive to them, and that addressed issues of medicine and agriculture without being institutionally subservient. What is striking, given the expectation by many that Stanley would ‘be able to drive his dream through to completion,” was that in fact he did not. Biochemists who had succeeded in making their expertise valued in specialized niches were resistant to giving up their affiliations to joint Stanley's “liberated” organization. Stanley's failure was not simply due to institutional factors: researchers as well as Rockefeller Foundation officers faulted him for his lack of scientific imagination, which made it difficult for him to gain credibility in leading the field. Moreover, many biochemists did not share Stanley's commitment to viruses as the key material for the “new biochemistry.”In the end, Stanley's free-standing department did become a first-rate department of biochemistry, but only after freeing itself from Stanley's leadership and his single-minded devotion to viruses. Nonetheless, the falling-out with the Berkeley biochemists was rapidly followed by the establishment of a Department of Molecular Biology, attesting to the unabating economic and institutional possibilities for an authoritative “general biology” (or two, for that matter) to take hold. In each case, following Stanley's dream sheds light on how the possible and the real shaped the (re)formation of biochemistry and molecular biology as postwar life sciences. (shrink)

This paper proceeds from an analysis (Callaway 1992, pp. 239-240) of a role of conflict in the origin of value commitments, a pervasive sociological pattern in the development of unifying group values which transforms personal conflicts, or differences, into large-scale collective conflicts. I have urged that these forces are capable of distorting even the cognitive processes of science and that they are a chief reason why value claims are regarded as incapable of objective evaluation. The thesis of the present paper (...) is that romantic collectivism (uncritical attachment to an identification group) renders members passive with respect to the ideals or content embodied in collective identity and that this is often exploited to convert groups into instruments of personal power. The issue is examined by reference to Reinhold Niebuhr's 1932 thesis of the inevitability of group egoism and inter-group conflicts and an opposing pragmatist conception of moral development, self-identity, and the individual's relationship to reference communities. (shrink)

This volume contains a series of papers which were presented at the 22nd Mediävistentagung held at Cologne, 3-6 September, 1980. It includes a forward by A. Zimmerman, and the following studies: W. P. Eckert, on legends about Albert the Great; F. J. Kovach, on the infinity of the divine essence and divine power according to Albert; J. I. Saranyana, on Albert's contribution to the doctrine of actus essendi; R. McInerny, on Albert and Thomas on Theology; W. J. Hoye, on salvation (...) and resurrection in Albert; A. Zimmerman, on Albert's critique of an argument to prove that the world began to be; S. Ebbesen, on Albert's Companion to the Organon; I. Craemer-Ruegenberg, on Albert's teaching concerning the soul and the intellect; A. Goddu, on Albert's contribution to discussions of natural and violent motions; G. C. Anawati, on Albert and alchemy; K. Bernath, on Albert's views concerning education as presented in his Commentary on the Politics; A. Cazenave, on some European views of the exotic at the time of Albert; G. Federici Vescovini, on some witnesses to Albert's influence at Padua at the end of the fourteenth century--Angelo of Fossombrone and Biagio Pelacni of Parma; M. Markowski, on Albert and Albertism at Krakow; S. Wlodek, on Albert and the Albertists of the fifteenth century and the problem of universals; J. Korolec, on Heymeric de Campo and his Neoplatonic vision of God; H. G. Senger, on Albertism and some reflections on the via Alberti in the fifteenth century; G. Piaia, on the historical and philosophical interpretations of Albert which developed from the fifteenth to the eighteenth centuries; M. Borzyszkowski, on Albert and his influence in Ermland, Pomesanien, and Pommerellen ; H. Kümmerling, "'Das muss alles einen andern geistlichen Sinn haben'. De concordiae mundanae rationibus," a contribution to the history of music. While limitations of space preclude detailed discussions of these articles, their variety in terms of the particular issues treated reflects both the interdisciplinary character of the original meeting which occasioned them and the breadth of vision and talent of the volume's focal point-Albert the Great. Among articles of interest to students of Albert's philosophical thought are, to mention but a few, those by Kovach, Saranyana, Zimmermann, Ebbesen, Craemer-Ruegenberg, and Goddu. Zimmermann not only presents Albert's critique of argumentation intended to prove that the world began to be, but after noting Albert's agreement on this point with the view defended by Thomas Aquinas, Zimmermann then resumes his continuing discussion with another twentieth-century scholar--Fernand Van Steenberghen of Louvain-concerning the merits of the argumentation rejected by Thomas and by Albert. Zimmermann defends the view developed by Albert and by Thomas, while Van Steenberghen favors the position associated especially with Bonaventure--that one can demonstrate the temporal origin of the universe.--John F. Wippel, The Catholic University of America. (shrink)

The Nicomachean Ethics announces itself as a treatise on the highest human good, the “end” (t°low) of human life—eÈdaiµon€a or happiness. In the last chapter of the work (X 9) Aristotle makes it clear that the study of the happy lives of contemplation and political leadership, the virtues, friendship, and pleasure that has by then been carried out in investigating that good—these are the leading themes of the Ethics that he mentions there (1179a33-35)— leaves the treatise’s objectives not yet completely (...) achieved. He began the work by saying (I 1- 2) that the study it contains is intended as a contribution to “political knowledge” (politikØ §pistƵh) or the political capacity or power (dÊnaµiw).1 Its work will not be complete, he now says, until a successful reader (or hearer) has been brought actually to possess that knowledge or power—political knowledge, that is, the fully accomplished capacity for expert political engagement in affairs of state. In effect, the reader of the Nicomachean Ethics needs now to learn, further, the subjects of study to which Aristotle’s own Politics is devoted. Before the aim announced at the beginning of the Ethics can be achieved—that is, before we can fully define and explain in the right sort of way the highest human good, or eÈdaiµon€a (I’ll say more in just a moment about what this right sort of way is)—we need, as he puts it in NE X 9 (1180a32 ff.), to become expert in the establishment of good laws (noµoyetikÆ) and good constitutions (polite›ai, cf. 1181b14, 19, 21). One might find this a surprising claim. As Aristotle himself is in no doubt, eÈdaiµon€a is a feature of the lives of individual persons. On his account it is an activity, or a unified set of ac-. (shrink)

The idea of translating Gerdil into English is brilliant, the translation is very good and the introduction of William Frank precise and inspiring.... Rousseau proposes a complete break with tradition. A new man will arise who is severed from the whole heritage of the past. With him the history of mankind begins anew. In one sense we have here a transposition in the field of philosophy of education of the Cartesian cogito. The subject begins with himself. To this philosophical project (...) Gerdil opposes the idea of tradition. We have not made ourselves. Our parents have procreated us. The parents do not only procreate their offspring, they also introduce them into the natural and social reality, that is they educate. No education is possible without a lively dialogue with history and society. Since the beginning man stands in a close relationship to others, is made for the human society.... In these our times one form of modernity is collapsing and the mood of the day is an unclear postmodernity that in some of its versions could well be a return to barbarianism. All the more important is then that another form of modernity be rediscovered and brought to the attention of the American public. - Rocco Buttiglione, University of St. Pius V, Rome A timely translation of a compelling 18th century critique of Rousseau by the neglected Italian author, Hyacinth S. Gerdil. Gerdil's Anti-Emile may have been written as a critique of Rousseau's Emile, but it can equally be read as a critique of the philosophy embraced by the American educational establishment. Through the influence of John Dewey, Rousseau came to inform much of the educational theory regnant in the United States, with disastrous consequences, now acknowledge by nearly all. In a valuable preface to his translation, Professor Frank, drawing upon his experience both here and abroad, not only places Emile in context, but defends Gerdil's time-transcending, classical view of education against its modern detractors. "Gerdil," Frank tells us, "addressed his Anti-Emile to elders responsible for education, be they parents, teachers, or political authorities, who might find themselves swayed by the powerful rhetoric of Rousseau's Emile." The same may be said of this translation and its informative prefatory material, for it is clearly a study that will be valued by anyone interested in principled education. - Jude P. Dougherty, Catholic University of America Cover image: "Adam and Eve" by Tintoretto. St. Augustine's Press acknowledges the kind permission granted by la Scuola Grande di San Rocco, Venice, for the use of the image. All rights reserved by la Scuola Grande di San Rocco. (shrink)

Berkeley argues that claims about divine predication (e.g., God is wise or exists) should be understood literally rather than analogically, because like all spirits (i.e., causes), God is intelligible only in terms of the extent of his effects. By focusing on the harmony and order of nature, Berkeley thus unites his view of God with his doctrines of mind, force, grace, and power, and avoids challenges to religious claims that are raised by appeals to analogy. The essay concludes by showing (...) how a letter, supposedly by Berkeley, to Peter Browne ("discovered" in 1969 by Berman and Pittion) is, in fact, by John Jackson (1686-1763), controversial theologian and friend of Samuel Clarke. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:“The Whole Internal World His Own”: Locke and Metaphor ReconsideredS. H. ClarkWhy need I name thy Boyle, whose pious search, Amid the dark recesses of his works, The great Creator sought? And why thy Locke, Who made the whole internal world his own?Oh decus! Anglicae certe oh lux altera gentis!... Tu caecas rerum causas, fontemque severum Pande, Pater; tibi enim, tibi, veri magne Sacerdos, Corda patent hominum, atque altae (...) penetralia Mentis.Fourfold Annihilation & at the clangor of the Arrows of Intellect The innumerable Chariots of the Almighty appeard in Heaven And Bacon & Newton & Locke, & Milton & Shakespear & Chaucer1Two features of these encomia to John Locke, composed by James Thomson, Thomas Gray, and William Blake, are immediately striking. Firstly, they are delivered by poets in a tradition customarily seen as a reaction to the intellectual climate induced by Locke’s Essay, a book which Blake famously claimed to regard with “Contempt and Abhorrence.” 2 Secondly, the familiar and somewhat hackneyed characterizations of Locke as philosopher of common-sense, [End Page 241] empiricism, and liberal ideology are refreshingly absent. For Gray he is “veri magne Sacerdos,” great priest of truth; Thomson places him in a pantheon including Shakespeare, Milton, Spenser, and Chaucer; and this ranking is explicitly endorsed in Blake’s “Milton & Shakspear & Chaucer.” Comparable praise of Locke’s imaginative power is conspicuously absent from even the most generous tributes of recent commentators. 3Even if Locke’s philosophical contribution to a variety of debates is fully acknowledged, the question remains of why his major work, An Essay concerning Human Understanding, was held in such high popular esteem—veneration is not too strong a word—during the subsequent century. The text itself appears an improbable candidate for such canonization: George Saintsbury accused its prose of being “positively mean in every point of style,” 4 and certainly in comparison with the poised and lucid ironies of Berkeley and Hume, it cannot but appear prolix, diffuse, and repetitive. The chief (and frequently only) merit grudgingly accorded to it is of disarming informality. Rosalie Colie’s emphasis on the “exploitation of the generic and rhetorical possibilities in the essay form itself “ highlights the conscious manipulation of authorial distance through which Locke creates the effect of sprawling inclusiveness and incom-pletion, but at the expense of conceding that “in exchange for the frankness with which the essayist appeared to present his thinking self, he was allowed certain liberties from logical rigour.” 5 Though the suggestion that a major philosophical text seeks to evade “logical rigour” might seem damning enough, there is a still more insidious equation of Locke’s “middle-style,” his desire “to make, what I have to say, as easie and intelligible to all sort of Readers as I can,” with a complicity with the expectations of his audience. 6 Other critics, notably John Richetti, have put a more positive gloss on the “simple and fortuitously concocted circle of friends” to whom the Essay is addressed, but even these accounts have been obliged to stress the representative and consensual nature of Locke’s thought. 7 This view is perhaps most elegantly expressed by Leslie Stephen: “Locke ruled the thought of his own and the coming period [End Page 242] because he interpreted so completely the fundamental beliefs which had been worked out at this time. He ruled, that is, by obeying.” 8William Walker correctly observes that “identifying and interpreting metaphors of mind” in the Essay are “standard practices of mainstream philosophical commentary from Leibniz to Rorty,” but also notes that these analyses are usually concerned with the degree to which Locke’s reliance on figuration was at variance with and compromised his epistemological doctrine. 9 I would argue that the poetic tributes previously quoted offer a more suggestive and adequate guide to the original impact of his work. In order to substantiate this claim, I shall begin by examining Locke’s apparent renunciation of, yet paradoxical dependence upon metaphor; go on to look at the connection of the “Horizon” to the elegiac presentation of memory and the ethic of mental “Labour”; and conclude by analyzing the complex interdependence of candle and sun within the light imagery employed in the... (shrink)