During his lifetime, F.C.S. Schiller was viewed as a major figure in the pragmatist movement, but his reputation has faded. This article will challenge the view that he was an unoriginal or less important figure. In particular, I will attempt a reconstruction of Schiller’s position on first philosophy, which will examine the differences between Schiller and the other major figures in the pragmatist movement. By using texts from Schiller’s writings, I attempt to create an undistorted reconstruction of what he wrote (...) in order to support this interpretation. I outline the implicit system contained in Schiller’s scattered writings and briefly examine the relation between Schiller’s humanism and other forms of pragmatism. The task seems both justified and worthwhile, since his work has been neglected, despite his prominence in the debates over pragmatism that took place when it emerged at the beginning of the twentieth century. (shrink)

We report the identification of a recurrent, 520-kb 16p12.1 microdeletion associated with childhood developmental delay. The microdeletion was detected in 20 of 11,873 cases compared with 2 of 8,540 controls and replicated in a second series of 22 of 9,254 cases compared with 6 of 6,299 controls. Most deletions were inherited, with carrier parents likely to manifest neuropsychiatric phenotypes compared to non-carrier parents. Probands were more likely to carry an additional large copy-number variant when compared to matched controls. The clinical (...) features of individuals with two mutations were distinct from and/or more severe than those of individuals carrying only the co-occurring mutation. Our data support a two-hit model in which the 16p12.1 microdeletion both predisposes to neuropsychiatric phenotypes as a single event and exacerbates neurodevelopmental phenotypes in association with other large deletions or duplications. Analysis of other microdeletions with variable expressivity indicates that this two-hit model might be more generally applicable to neuropsychiatric disease. © 2010 Nature America, Inc. All rights reserved. (shrink)

BackgroundIn the Canadian Alliance for Healthy Hearts and Minds (CAHHM) cohort, participants underwent magnetic resonance imaging (MRI) of the brain, heart, and abdomen, that generated incidental findings (IFs). The approach to managing these unexpected results remain a complex issue. Our objectives were to describe the CAHHM policy for the management of IFs, to understand the impact of disclosing IFs to healthy research participants, and to reflect on the ethical obligations of researchers in future MRI studies.MethodsBetween 2013 and 2019, 8252 participants (...) (mean age 58 ± 9 years, 54% women) were recruited with a follow-up questionnaire administered to 909 participants (40% response rate) at 1-year. The CAHHM policy followed a restricted approach, whereby routine feedback on IFs was not provided. Only IFs of severe structural abnormalities were reported.ResultsSevere structural abnormalities occurred in 8.3% (95% confidence interval 7.7–8.9%) of participants, with the highest proportions found in the brain (4.2%) and abdomen (3.1%). The majority of participants (97%) informed of an IF reported no change in quality of life, with 3% of participants reporting that the knowledge of an IF negatively impacted their quality of life. Furthermore, 50% reported increased stress in learning about an IF, and in 95%, the discovery of an IF did not adversely impact his/her life insurance policy. Most participants (90%) would enrol in the study again and perceived the MRI scan to be beneficial, regardless of whether they were informed of IFs. While the implications of a restricted approach to IF management was perceived to be mostly positive, a degree of diagnostic misconception was present amongst participants, indicating the importance of a more thorough consent process to support participant autonomy.ConclusionThe management of IFs from research MRI scans remain a challenging issue, as participants may experience stress and a reduced quality of life when IFs are disclosed. The restricted approach to IF management in CAHHM demonstrated a fair fulfillment of the overarching ethical principles of respect for autonomy, concern for wellbeing, and justice. The approach outlined in the CAHHM policy may serve as a framework for future research studies.Clinical trial registrationhttps://clinicaltrials.gov/ct2/show/nct02220582. (shrink)

A lineage of prominent philosophers who have discussed the second-person relation can be regarded as advancing structural accounts. They posit that the second-person relation effects one transformative change to the structure of practical reasoning. In this paper, I criticise this orthodoxy and offer an alternative, substantive account. That is, I argue that entering into second-personal relations with others does indeed affect one's practical reasoning, but it does this not by altering the structure of one's agential thought, but by changing what (...) reasons can become available. The importance of second-personal thought for action is heterogenous. Second-person relations make possible the emergence of a wide variety of different kinds of practical reasons: creating some, revealing others. Recognising this diminishes the appeal of the traditional, structural accounts of the practical significance of such second-personal relations. Moving away from structural accounts facilitates a more thorough understanding of the intersubjective form of action. (shrink)

This handbook with exercises reveals the mathematical beauty of formalisms hitherto mostly used for software and hardware design and verification.

“Smallpox was always present, filling the churchyard with corpses, tormenting with constant fear all whom it had not yet stricken, leaving on those whose lives it spared the hideous traces of its power, turning the babe into a changeling at which the mother shuddered, and making the eyes and cheeks of the betrothed maiden objects of horror to the lover.” In 1848, British historian T.B. Macaulay first captured the picture of the devastation smallpox wreaked on its victims, but the “King (...) of Terrors,” as it was dubbed by future president John Adams, had already decimated populations in the ancient world from Greece to Egypt to China. Smallpox had no respect for authority: the earliest identified victim, Pharaoh Ramses V was but the first in a long line of monarchs and rulers who succumbed,. including the Hittite king Suppiluliumas I, Aztec Emperor Cuitlahuac, and Queen Mary II of England. (shrink)

“Smallpox was always present, filling the churchyard with corpses, tormenting with constant fear all whom it had not yet stricken, leaving on those whose lives it spared the hideous traces of its power, turning the babe into a changeling at which the mother shuddered, and making the eyes and cheeks of the betrothed maiden objects of horror to the lover.” In 1848, British historian T.B. Macaulay first captured the picture of the devastation smallpox wreaked on its victims, but the “King (...) of Terrors,” as it was dubbed by future president John Adams, had already decimated populations in the ancient world from Greece to Egypt to China. Smallpox had no respect for authority: the earliest identified victim, Pharaoh Ramses V was but the first in a long line of monarchs and rulers who succumbed,. including the Hittite king Suppiluliumas I, Aztec Emperor Cuitlahuac, and Queen Mary II of England. (shrink)

First published in 1935, The Life and Writings of Giambattista Vico is a succinct biography of the Italian philosopher, Giambattista Vico. Carefully documented, the book comments on Vico's life as well as his oeuvre in a bid to extend his audience to the English-speaking population. From his early childhood to the influence of his writings after his death, the book provides a keen insight into the many facets of his philosophy. This book will be of interest to students of philosophy (...) and history. (shrink)

First Published in 1999. Routledge is an imprint of Taylor & Francis, an informa company.

Poverty violates fundamental human values through its impact on individuals and on human environments, and it goes against the core values of democratic societies. Drawing on numerous scientific studies as well as his own experience witnessing the systematic poverty in his home country of South Africa, H. P. P. [Hennie] Lötter presents a holistic profile of poverty and its effects on human lives all the while accounting for the complexity of each individual case. He argues that shared ethical values must (...) guide the planning and distribution of aid and that our society must reevaluate our notions of justice and reimagine the role of the state in order to enable collective human responsibility for poverty’s successful eradication. (shrink)

Dilthey is a figure of real importance in European philosophy and social theory. He exerted a significant influence on Husserl, Heidegger and Weber through his work on the nature of philosophy and the methodology and epistemology of human and social studies. He was also a distinguished and original historian of ideas and, indeed, many of his philosophical interests arose from the insights and practical difficulties he encountered as a historian. He produced a monumental biography of Schleiermacher, and a series of (...) shorter, but no less striking studies of Hegel, Dickens, Shakespeare, Schiller and many others. (shrink)

The articles published in this volume will bring that knowledge which alone fortifies a student against wrong or fanciful occultism, as against the perils of ...

Summary. — The following theorem is proved.: If the statistical predictions of quantum theory are true in general and. if the macroscopic world is not radically different from what is observed, then what happens macroscopically in one space-time region must in some cases depend on variables that are controlled by experimenters in far-away, space-like-separated. regions. By what happens macroscopically in one space-time region is meant specifically the occurrence or nonoccurrence of a macroscopic event, such as the d.etection and recording of (...) a particle by some macroscopic device. By a variable controlled. by an experimenter in a certain space-time region is meant specifically the experimental setting in that region of some macroscopic device, in which this setting is controlled. by an experimenter acting within that region. The theorem pertains speci6cally to experimental situations in which there .are two far-apart, spacelike-separated. regions in each of which there is a device that can be set at either of two alternative settings by an experimenter acting within ' that region. There. is also a long sequence of experimental results (4.e. events) in each of the two regions. The theorem asserts that, for some such cases, it is mathematically impossible, within the manifold. (shrink)