In this article we raise a problem, and we offer two practical contributions to its solution. The problem is that academic communities interested in digital publishing do not have adequate tools to help them in choosing a publishing model that suits their needs. We believe that excessive focus on Open Access (OA) has obscured some important issues; moreover exclusive emphasis on increasing openness has contributed to an agenda and to policies that show clear practical shortcomings. We believe (...) that academic communities have different needs and priorities; therefore there cannot be a ranking of publishing models that fits all and is based on only one criterion or value. We thus believe that two things are needed. First, communities need help in working out what they want from their digital publications. Their needs and desiderata should be made explicit and their relative importance estimated. This exercise leads to the formulation and ordering of their objectives. Second, available publishing models should be assessed on the basis of these objectives, so as to choose one that satisfies them well. Accordingly we have developed a framework that assists communities in going through these two steps. The framework can be used informally, as a guide to the collection and systematic organization of the information needed to make an informed choice of publishing model. In order to do so it maps the values that should be weighed and the technical features that embed them. Building on our framework, we also offer a method to produce ordinal and cardinal scores of publishing models. When these techniques are applied the framework becomes a formal decision–making tool. Finally, the framework stresses that, while the OA movement tackles important issues in digital publishing, it cannot incorporate the whole range of values and interests that are at the core of academic publishing. Therefore the framework suggests a broader agenda that is relevant in making better policy decisions around academic publishing and OA. (shrink)

The potential of using personalized Large Language Models (LLMs) or “generative AI” (GenAI) to enhance productivity in academic research, as highlighted by Porsdam Mann and colleagues (Porsdam Mann...

The productivity of researchers and the impact of the work they do are a preoccupation of universities, research funding agencies, and sometimes even researchers themselves. The h-index is the most popular of different metrics to measure these activities. This research deals with presenting a practical approach to model the h-index based on the total number of citations and the duration from the publishing of the first article. To determine the effect of every factor on h, we applied a (...) set of simple nonlinear regression. The results indicated that both NC and D1 had a significant effect on h. The determination of coefficient for these equations to estimate the h-index was 93.4% and 39.8%, respectively, which verified that the model based on NC had a better fit. Then, to record the simultaneous effects of NC and D1 on h, multiple nonlinear regression was applied. The results indicated that NC and D1 had a significant effect on h. Also, the determination of coefficient for this equation to estimate h was 93.6%. Finally, to model and estimate the h-index, as a function of NC and D1, multiple nonlinear quartile regression was used. The goodness of the fitted model was also assessed. (shrink)

The academic journal publishing model is deeply unethical: today, a few major, for-profit conglomerates control more than 50 of all articles in the natural sciences and social sciences, driving subscription and open-access publishing fees above levels that can be sustainably maintained by publicly funded universities, libraries, and research institutions worldwide. About a third of the costs paid for publishing papers is profit for these dominant publishers' shareholders, and about half of them covers costs to keep the (...) system running, including lobbying, marketing fees, and paywalls. The paywalls in turn restrict access of scientific outputs, preventing them from being freely shared with the public and other researchers. Thus, money that the public is told goes into science is actually being funneled away from it, or used to limit access to it. Alternatives to this model exist and have increased in popularity in recent years, including diamond open-access journals and community-driven recommendation models. These are free of charge for authors and minimize costs for institutions and agencies, while making peer-reviewed scientific results publicly accessible. However, for-profit publishing agents have made change difficult, by co-opting open-access schemes and creating journal-driven incentives that prevent an effective collective transition away from profiteering. Here, we give a brief overview of the current state of the academic publishing system, including its most important systemic problems. We then describe alternative systems. We explain the reasons why the move toward them can be perceived as costly to individual researchers, and we demystify common roadblocks to change. Finally, in view of the above, we provide a set of guidelines and recommendations that academics at all levels can implement, in order to enable a more rapid and effective transition toward ethical publishing. (shrink)

PAMVEC is a novel vehicle modeling tool designed to complement the capabilities of dynamic vehicle simulators and be better-suited to the purposes of vehicle technology assessment. This paper presents a validation of PAMVEC against published data for a range of production and pre-production prototype vehicles whose powertrain technologies span the range currently being exhibited by automotive manufacturers. For each vehicle, the PAMVEC model was used to predict the fuel/energy consumption and required peak powertrain output due to acceleration performance. Errors (...) typically. (shrink)

The ‘model approach’ facilitates a quantitative-oriented study of conceptual changes in large corpora. This paper implements the ‘model approach’ to investigate the erosion of the traditional art-nature distinction in early modern natural philosophy. I argue that a condition for this transformation has to be located in the late scholastic conception of final causation. I design a conceptual model to capture the art-nature distinction and formulate a working hypothesis about its early modern fate. I test my hypothesis on (...) a selected corpus of 25 works published in the Dutch academic milieu between 1607 and 1748. I analyse the corpus through a procedure based on concordancing of keywords associated with the model. I argue that the results obtained constitute a successful pilot study for the implementation of the model approach on larger scale research. (shrink)

The papers collected in this volume were written over a period of some eight or nine years, with some still earlier material incorporated in one of them. Publishing them under the same cover does not make a con tinuous book of them. The papers are thematically connected with each other, however, in a way which has led me to think that they can naturally be grouped together. In any list of philosophically important concepts, those falling within the range of (...) application of modal logic will rank high in interest. They include necessity, possibility, obligation, permission, knowledge, belief, perception, memory, hoping, and striving, to mention just a few of the more obvious ones. When a satisfactory semantics (in the sense of Tarski and Carnap) was first developed for modal logic, a fascinating new set of methods and ideas was thus made available for philosophical studies. The pioneers of this model theory of modality include prominently Stig Kanger and Saul Kripke. Several others were working in the same area independently and more or less concurrently. Some of the older papers in this collection, especially 'Quantification and Modality' and 'Modes of Modality', serve to clarify some of the main possibilities in the semantics of modal logics in general. (shrink)

[Correction Notice: An erratum for this article was reported in Vol 109 of Psychological Review. Due to circumstances that were beyond the control of the authors, the studies reported in "Models of Ecological Rationality: The Recognition Heuristic," by Daniel G. Goldstein and Gerd Gigerenzer overlap with studies reported in "The Recognition Heuristic: How Ignorance Makes Us Smart," by the same authors and with studies reported in "Inference From Ignorance: The Recognition Heuristic". In addition, Figure 3 in the Psychological Review article (...) was originally published in the book chapter and should have carried a note saying that it was used by permission of Oxford University Press.] One view of heuristics is that they are imperfect versions of optimal statistical procedures considered too complicated for ordinary minds to carry out. In contrast, the authors consider heuristics to be adaptive strategies that evolved in tandem with fundamental psychological mechanisms. The recognition heuristic, arguably the most frugal of all heuristics, makes inferences from patterns of missing knowledge. This heuristic exploits a fundamental adaptation of many organisms: the vast, sensitive, and reliable capacity for recognition. The authors specify the conditions under which the recognition heuristic is successful and when it leads to the counter-intuitive less-is-more effect in which less knowledge is better than more for making accurate inferences. (shrink)

Through use of decision?making expertise already in place, newspaper publishers already possess elemental tools required for ethical decision?making relating to extent of participation in civic activities. By also considering added qualitative factors that embrace broad perspective, detachment, and declaration, decisions are more likely to be adequately informed. This article suggests that publishers become active in building business and community leadership models strong enough to allay critics who question ethical motives.

Journals regulate a significant portion of the communication between scientists. This paper devises an agent-based model of scientific practice and uses it to compare various strategies for selecting publications by journals. Surprisingly, it appears that the best selection method for journals is to publish relatively few papers and to select those papers it publishes at random from the available “above threshold” papers it receives. This strategy is most effective at maintaining an appropriate type of diversity that is needed to (...) solve a particular type of scientific problem. This problem and the limitation of the model is discussed in detail. (shrink)

The author argues that the new digital possibilities in scientific communication do not imply, by any means, that many old requirements are becoming dispensable. The essential elements of the system, such as quality assurance, authenticity, orientation and navigation will still demand considerable expense. The overall system costs will rather be higher in a hybrid system. In the second part of his lecture, the author discusses the two fundamentally different open access models, the Golden Road, which is supposed to be able (...) to operate, eventually, without any publishers, and the Green Road, whose functioning is based on primary publication through publishing houses. Finally, the basic issue of the indispensable qualitative stratigraphy of scientific documents is addressed. For this, the published journals, which also provide topical focus and, thus, orientation as well as active marketing in terms of optimal diffusion, still are a very capable tool. It is questionable to what extent these tasks could be fulfilled by university-based repositories. The publishing houses, on the other hand, have a proven track record of providing a wide range of useful value-adding services in digital publishing. (shrink)

Background: Health researchers must weigh the benefits and risks of publishing their findings.Objective: To explore differences in decision making between rural health researchers and managers on the publication of research from small identifiable populations.Method: A survey that investigated the attitudes of Australian rural general practitioners to nurse practitioners was explored. Decisions on the study’s publication were analysed with bioethical principles and health service management ethical decision-making models.Results: Response rate was 78.5% . 84–94% of GP responders considered it to be (...) undesirable for nurse practitioners to initiate referrals to medical specialists , to initiate diagnostic imaging and to prescribe medication .Bioethical analysis: It was concluded that the principle of beneficence outweighed the principle of non-maleficence and that a valid justification for the publication of these results existed.Decision-making models of health service managers: On the basis of models of ethical decision making in health service management, the decisions of the area’s health managers resulted in approval to publish this project’s results being denied. This was because the perceived risks to the health service outweighed benefits. Confidentiality could not be ensured by publication under a regional nom de plume.Conclusions: A conflict of interests between rural researchers and health managers on publication of results is shown by this case study. Researchers and managers at times owe competing duties to key stakeholders. Both weigh the estimated risks and benefits of the effect of research findings. This is particularly true in a rural area, where identification of the subjects becomes more likely. (shrink)

For most literary sociologists serious modern work starts with Robert Escarpit’s Sociologie de la Littérature , a book which proposes that sociology can usefully explain how literature operates as a social institution. Subsequent Escarpit-inspired work on the literary enterprise covers topics such as the profession of authorship; the stratified “circuits” of production, distribution, and consumption; and the commodity aspect of literature. Critics have objected that Escarpit’s increasingly macroquantitative and statistics-bound procedures bleach out literary and ideological texture. And his model (...) of literature as discrete social system encourages the abstract model making which Raymond Williams despises.1 But, whatever its shortomcings, Escarpit’s definition of literary product and practice as social faits forms an essential starting point for the sociologist intending to investigate the apparatuses of literature.In what follows, I shall mainly fix on a problem currently disabling constructive research on the literary-sociological lines projected by Escarpit: namely, scholarly ignorance about book trade and publishing history technicalities. This sets up, I shall suggest, a large and troubling hole at the centre of the subject, and there is little indication, at this stage, how or when the hole is to be filled. 1. See Raymond Williams, “Literature and Sociology,” Problems in Materialism and Culture: Selected Essays , pp. 11-30. John Sutherland is professor of literature at the California Institute of Technology. His books include Fiction and the Fiction Industry , Bestsellers , and Offensive Literature . He is currently completing an encyclopedia of Victorian fiction. (shrink)

A new technology paired with a viable business model will have disruptive impact on incumbent companies in a speci c market, if they do not re- evaluate and update their business models accord- ingly. As the Internet matures, Semantic Web technologies enable applications for meaning- based and dynamic ltering and processing of information, which has a disruptive impact on sci- enti c publishing. This article calls for publishers to adopt seman- tic technologies and emphasises the “need to in- (...) clude a semantic strategy in their business models” (Hawkins 2009). With a focus on journals as the ‘cash cow’ of scienti c publishers, it assembles de- bates about disruption and general tendencies in scienti c publishing. An introduction to Semantic Web, Text Mining and Semantic Publishing is given as well as various examples of product developments, company partnerships and acquisitions related to semantic technologies. Finally, different ways of acquiring semantic annotation data and nancial aspects of semantic enhancements are discussed. (shrink)

Business models for biomedical research prescribe decentralization due to market selection pressures. I argue that decentralized biomedical research does not match four normative philosophical models of the role of values in science. Non-epistemic values affect the internal stages of for-profit biomedical science. Publication planning, effected by Contract Research Organizations, inhibits mechanisms for transformative criticism. The structure of contracted research precludes attribution of responsibility for foreseeable harm resulting from methodological choices. The effectiveness of business strategies leads to overrepresentation of profit values (...) versus the values of the general public. These disconnects in respect to the proper role of values in science results from structural issues ultimately linked to the distinct goals of business versus applied science, and so it seems likely that disconnects will also be found in other dimensions of attempts to combine business and science. The volume and integration in the publishing community of decentralized biomedical research imply that the entire community of biomedical research science cannot match the normative criteria of community-focused models of values in science. Several proposals for changing research funding structure might successfully relieve market pressures that drive decentralization. (shrink)

This research was conducted to examine the psychological profiles of people who publish their weblogs on the Internet and the characteristics of their community. Weblogs can be defined as online sites, not owned by major corporations, which are frequently updated by one or more people. Weblogs provide an opportunity to develop communication through information sharing with other Internet users. Our particular focus is on authors of “informative” weblogs, who have a powerful desire to provide information and share their knowledge, rather (...) than other weblog forms, such as “diary-like” weblogs, in which the authors have a more powerful need for self-disclosure and the resulting interactions. The results of online author surveys suggested that the system of weblog have many benefits for supporting knowledge community and the weblog authors were oriented to reciprocal information interchange and perceive much psychological benefits from it. (shrink)

The paper aims to analyse the structure of the formed models of congruence of personal and organizational values, opportunities of their application in order to conceptualize the guidelines for the formation of an integrated model. The models for analysis were selected from the articles published in international databases with the keywords associated with value congruence models and grouped by the types of models: models that represent the origin of the phenomenon of value congruence and methodology of evaluation, and models, (...) which depict the impact of value congruence on the employee and activities of the organization. The main result of this research is a complex analysis of all models of congruence of personal and organizational values presented in the scientific literature, in the aspect of their structure, content and practical application. It was found that the essential elements of the models analysed are personal values, organizational values, congruence of personal and organizational values and the influence of congruence on the person and the organization. However, the models lack not only the scientific substantiation of the influence of the phenomenon of value congruence on the person and the organization, but also practical recommendations on how to achieve strong value congruence in the organization. This article exclusively presents the analysis of models developed by different scientists, but the obtained results of empirical studies are not compared statistically, applying certain models in practice. Such criteria as the sample size, the nature of activities of the organizations were not analysed and the states, in which the studies were carried out with the application of the analysed models, are not emphasized. This study also does not aim to determine the most appropriate diagnostic instrument for evaluation of value congruence, leaving the open way for the further discussions. The originality of this research is presupposed by the fact that it presents most of the models described in the scientific literature that evaluate the congruence of personal values of employees and the values prevailing in the organization. This will help the researchers of value congruence form a clear view about the models published in scientific literature, not to be disorientated in the diversity of the presented models and look for new directions for improvement of models of value congruence. A newly developed complex model of value congruence also offered to executives of organizations will help perceive the process of formation of this phenomenon and its benefits, and understand how to manage this phenomenon in practice. (shrink)

In the academic community, predatory publishers are exploiting academic integrity and the open access publishing model. Academicians receive numerous spam e-mail messages inviting article submissions each day which deceive authors by promising fast review and publication. The content of these emails present arguments in a way to appear as legitimate and valid to grab the attention of authors. Therefore, the aim of this paper is to advance insights into the arguments deployed by fake journals in their attempt to (...) convey specific indexicalities of identity and truthfulness. As a result of thematic analysis of 50 email messages from such journals, this research drew on two main themes-explicit and implicit arguments and their most frequent subcategories which were formal lexicon/grammar and fast peer- reviewed process. These arguments were, further, mapped on to Toulmin’s Model of Argumentation to find out more about the strength of the information used to support their claim. Utilizing Toulmin’s model, the findings highlighted the fact that there were instances of discursive deviations or “hidden rebuttals” that revealed the predatory journals’ ingenuity. (shrink)

This book publishes 31 of the author's selected papers which have appeared, with one exception, since 1970. The papers cover a wide range of topics in the philosophy of science. Part I is concerned with general methodology, including formal and axiomatic methods in science. Part II is concerned with causality and explanation. The papers extend the author's earlier work on a probabilistic theory of causality. The papers in Part III are concerned with probability and measurement, especially foundational questions about probability. (...) Part IV consists of several papers, including two historical ones, on the foundations of physics, with the main emphasis being on quantum mechanics. Part V, the longest part, is on the foundations of psychology and includes papers mainly on learning and perception. The book is aimed at philosophers of science, scientists concerned with the methodology of the social sciences, and mathematical psychologists interested in theories of learning, perception and measurement. (shrink)

Research programs regularly compete to achieve the same goal, such as the discovery of the structure of DNA or the construction of a TEA laser. The more the competing programs share information, the faster the goal is likely to be reached, to society’s benefit. But the “priority rule”-the scientific norm according to which the first program to reach the goal in question must receive all the credit for the achievement-provides a powerful disincentive for programs to share information. How, then, is (...) the clash between social and individual interest resolved in scientific practice? This chapter investigates what Robert Merton called science’s “communist” norm, which mandates universal sharing of knowledge, and uses mathematical models of discovery to argue that a communist regime may be on the whole advantageous and fair to all parties, and so might be implemented by a social contract that all scientists would be willing to sign. (shrink)

Published originally in: Patoluoto, I., Saarinen, E., Stenman, P.,. Vexing Questions, An Urnful of Essays in Honour of Veikko Rantala on the Occasion of His Fiftieth Birthday. Reports from the Department of Philosophy, University of Helsinki, 3, pp. 12–18.

Several theoretical publications on the Dirac equation published during the last decades have shown that, an interpretation is possible, which ascribes the origin of electron spin and magnetic moment to an autonomous circular motion of the point-like charged particle around a fixed centre. In more recent publications an extension of the original so called “Zitterbewegung Interpretation” of quantum mechanics was suggested, in which the spin results from an average of instantaneous spin vectors over a Zitterbewegung period. We argue that, the (...) corresponding autonomous motion of the electron should, if it is real, determine non-relativistic spin measurements. Such a direct connection with the established formal quantum mechanical description of spin measurements, into which spin is introduced as a “non-classical” quantity has, to our knowledge, not been reported. In the present work we show that, under certain “model assumptions” concerning the proposed autonomous motion, results of spin measurements, including measurements of angular correlations in singlet systems, can indeed be correctly described using classical probabilities. The success of the model is evidence for the “reality” of the assumed autonomous motion. The resulting model violates the Bell—inequalities to the same extent as quantum mechanics. (shrink)

Esta introdução descreve os mais importantes dados biográficos da vida e da obra do físico teórico austríaco Ludwig Boltzmann (1844-1906). As principais contribuições científicas de Boltzmann situam-se nos domínios da teoria cinética dos gases e mecânica estatística, da qual ele foi um dos fundadores. A tese de que as teorias científicas são representações dos fenômenos naturais é encontrada em todos os artigos de Boltzmann. No verbete "modelo", ela é apresentada de modo mais organizado, o que o torna uma peça fundamental (...) para a compreensão do pensamento filosófico do físico austríaco. O verbete, publicado na famosa enciclopédia Britannica, foi escrito para o público em geral. Ainda assim, Boltzmann não se eximiu de tomar partido em favor do uso de modelos. Estes últimos não apenas seriam inevitáveis, mas necessários, uma vez que tornavam possível o aperfeiçoamento contínuo da ciência. This introduction describes the most important biographical details of the life and work of the Austrian theoretical physicist Ludwig Boltzmann (1844-1906). The main scientific contributions of Boltzmann can be found in areas such as the kinetic theory of gases and statistical mechanics, of which he was one of the co-founders. The thesis that scientific theories are representations of natural phenomena is found in all philosophical articles by Boltzmann. In the entry "model", published in the celebrated Encyclopedia Britannica, the thesis is presented in a more organized way, making it the keystone to understand the philosophical thought of the Austrian physicist. Although the entry was written for the general public, in it Boltzmann did not refrain from taking sides as far as the use of models is concerned. According to him, the latter would not only be inevitable, but in fact necessary, since they would made possible the continuous improvement of science. (shrink)

This paper aims to analyse Husserl’s texts in order to evaluate his attempt to apply a model of intentionality as interpretation(Auffassung) of a content (Inhalt) he had earlier developed to explain a notion of timeconsciousness. In Husserl’s previous published work the Logical Investigations (1900‐01), he construed perceptual intentionality on the model of apprehending intention and apprehended sensual contents for an ordinary object. For later published work, the so‐called early lectures on The Phenomenology of Internal Time-Consciousness (1928), he continued (...) to apply the model to analyse temporal objects both in the awareness of duration and in the temporal flow. Brough presented that Husserl’s attempt to apply the model culminated in its rejection. The paper postulates that Husserl did not fail, but in fact was a success. Husserl succeeded in applying the model as a foundation method for investigating the occurrence of remembrance of elapsed temporal objects. In the end he found a suitable way to determine what is actually temporal now, before and after in the continuous stream of time‐consciousness. Without interpretation of a content model, the Husserlian phenomenology that everyone is conscious of the same thing, appearing as such, at the same time, cannot be possible. (shrink)

This paper presents a four layer model for working with legal knowledge in expert systems. It distinguishes five sources of knowledge. Four contain basic legal knowledge found in published and unpublished sources. The fifth consists of legal metaknowledge. In the model the four basic legal knowledge sources are placed at the lowest level. The metaknowledge is placed at levels above the other four knowledge sources. The assumption is that the knowledge is represented only once. The use of metaknowledge (...) at various levels should make it possible to use the appropriate knowledge for the problem presented to the system. The knowledge has to be represented as closely to the original format as possible for this purpose. Suitable representation formalisms for the various types of knowledge in the five knowledge sources are discussed. It is not possible to indicate a best representation formalism for each knowledge source. (shrink)

Using a decision theoretic model of scientists’ time allocation between potential research projects I explain the fact that on average women scientists publish less research papers than men scientists. If scientists are incentivised to publish as many papers as possible, then it is necessary and sufficient for a productivity gap to arise that women scientists anticipate harsher treatment of their manuscripts than men scientists anticipate for their manuscripts. I present evidence that women do expect harsher treatment and that scientists’ (...) are incentivised to publish as many papers as possible, and discuss some epistemological consequences of this conjecture. (shrink)

Despite efforts from regulatory agencies (e.g. NIH, FDA), recent systematic reviews of randomised controlled trials (RCTs) show that top medical journals continue to publish trials without requiring authors to report details for readers to evaluate early stopping decisions carefully. This article presents a systematic way of modelling and simulating interim monitoring decisions of RCTs. By taking an approach that is both general and rigorous, the proposed framework models and evaluates early stopping decisions of RCTs based on a clear and consistent (...) set of criteria. The framework allows decision analysts to generate and quickly answer ‘what-if’ questions by simulating alternate trial scenarios. I illustrate the framework with a case study of an RCT that was stopped early due to harm. This was a trial of vitamin A supplement in relation to HIV transmission from mother-to-child through breastfeeding. (shrink)

This bibliographical review of the modelling of the mitotic apparatus covers a period of one hundred and twenty years, from the discovery of the bipolar mitotic spindle up to the present day. Without attempting to be fully comprehensive, it will describe the evolution of the main ideas that have left their mark on a century of experimental and theoretical research. Fol and Bütschli's first writings date back to 1873, at a time when Schleiden and Schwann's cell theory was rapidly gaining (...) ground throughout Germany. Both mitosis and chromosomes were to be discovered within the space of thirty years, along with the two key events in the animal and plant reproductive cycle, namely fecondation and meiosis. The mitotic pole, a term still in use to this day, was employed to describe a morphological fact which was noted as early as 1876, namely that the lines and the dots of the karyokinetic figure, with its spindle and asters, looks remarkably like the lines of force around a bar magnet. This was to lead to models designed to explain the movements of chromosomes which take place when the cell nucleus appears to cease to exist as an organelle during mitosis. The nature of those mechanisms and the origin of the forces behind the chromosomes' ordered movements were central to the debate. Auguste Prenant, in a remarkable bibliographical synthesis published in 1910, summed up the opposing viewpoints of the vitalists, on the one hand, who favoured the theory of contractility or extensility in spindle fibres, and of those who believed in models based on physical phenomena, on the other. The latter subdivided into two groups: some, like Bütschli, Rhumbler or Leduc, referred to diffusion, osmosis and superficial tension, whilst the others, led by Gallardo and Hartog, focussed on the laws of electromagnetism. Lillie, Kuwada and Darlington followed up this line of research. The mid-20th century was a major turning point. Most of the modelling mentioned above was criticized and fell into disuse after disappearing from research publications and textbooks.This marked the onset of a new era, as electron microscopes made possible the materialization and detailed study of the macromolecular elements of the fibres, filaments and microtubules of the cytoskeleton. The successive phases of (a) de Harven and Bernhard's 1956 discovery of the centriole's ultrastructure, (b) its identification with the basal body of the cilia and flagella, confirming the theory set out by Henneguy and von Lenhossek (1898–99), (c) the universal presence of microtubules in animal, vegetal and eukaryotic protist cells, (d) the polymerization-depolymerization induced reversible transformations of the tubulin pool in mitosing cells (Inoue, 1960), (e) ultrastructural comparative studies of the mitotic apparatus of eukaryotes illustrating the Pickett-Heaps integrating concept of the MTOC (microtubule-organizing centre), (f) the possibility ofin vitro experiments on mtocs or on microtubules, brings us upon the present day, which has seen the focus placed on the concept of motor-proteins (kinesin, dynein) and on cell cycle models. The latter are based on a close coincidence between the observable modifications of the mitotic apparatus and the periodic variations in intracellular concentrations of calcium or of certain enzymes (cyclins, Cdc2) during the main transitions of the cell cycle. (shrink)

It is my pleasure to open this special issue with which we like to celebrate the fifth birthday of our journal. What was originally conceived as one special issue of HYLE that has rapidly grown to a considerable number of high quality papers for which we need at least two issues. We received a total of 19 paper submissions, some of which are still under review. The manuscripts cover nearly every aspect of models outlined in the Call for Paper (HYLE (...) 4, pp. 171f.), and much more. As far as the review procedure allows, we are going to divide the topic roughly into three topical sections, each with about four contributions. The following four papers of the present volume make up the first section that is devoted to models in quantum and computational chemistry. The second section, to be published in the next issue, is more specifically on a very peculiar type of models in chemistry: molecular models. The third and last section will be on models of complex systems, in particular in biochemistry, geochemistry, and chemical engineering. (shrink)