Abstractc-Jun N-terminal kinases (JNKs) are intracellular stress-activated signalling molecules, which are controlled by a highly evolutionarily conserved signalling cascade. In mammalian cells, JNKs are regulated by a wide variety of cellular stresses and growth factors and have been implicated in the regulation of remarkably diverse biological processes, such as cell shape changes, immune responses and apoptosis. How can such different stimuli activate the JNK pathway and what roles does JNK play in vivo? Molecular genetic analysis of the Drosophila JNK gene (...) has started to provide answers to these questions, confirming the role of this molecule in development and stress responses and suggesting a conserved function for JNK signalling in processes such as wound healing. Here, we review this work and discuss how future experiments in Drosophila should reveal the cell type-specific mechanisms by which JNKs perform their diverse functions. BioEssays 20:1009–1019, 1998. © 1998 John Wiley & Sons, Inc. (shrink)

Enhancer detectors are DNA constructs which, when introduced into a eukaryotic genome, respond to nearby genomic transcriptional regulatory elements by means of a reporter gene, revealing the expression pattern of genes in their vicinity. Recent experiments in Drosophila suggest that enhancer detection is a powerful method to identify genes that are expressed in the nervous system. Since enhancer detectors allow a rapid molecular and genetic characterization of genes in their vicinity, the method will greatly facilitate the study of neural development (...) and behavior. (shrink)

This article expands on what Bernard Stiegler describes as “The Ordeal of Truth”. Through an evolutionary account of cognition and its exteriorization in human technology, I highlight a recurring tension in philosophy between the “as-if” nature of our models and representations, and the doubt that infects even our most stable understanding of the world. Truth is here associated to the process of metastabilization that characterizes the biological organism. The famous case of Clive Wearing’s severe amnesia, as well as the (...) fictional treatment of amnesia in Christopher Nolan’s Memento, are recalled to highlight the connection between truth and memory, and more importantly the contingent character of the formation of thoughts, and the desperate nature of the construction of truths, through the evolutionarily conditioned “subjective necessity” to link the before and the after, the cause and the effect. I show that this same ordeal is reflected in the philosophy of science in what is known as “pessimistic meta induction”, which I put into dialogue with the growing pessimism about knowledge in contemporary technological culture known as “post truth”. Finally, a possible way out of this pessimism is briefly sketched: a compromise such that, without recourse to objective truth, and in full acceptance of an always already biased relation to the world, future technologies might be designed to incrementally reduce our biases, through an intrinsic mapping of the relative falsity of our models, rather than through some idealized extrinsic relation to an unattainable noumenal real. (shrink)

This chapter talks about Clive Staples Lewis's thoughts regarding naturalism and morality. Lewis's view of morality and its relationship to happiness, along with his views about the intrinsic goodness of pleasure and the intrinsic evilness of pain, raises the specter of what is known in philosophy as Euthyphro's Dilemma. To illustrate what Lewis had in mind, it is helpful to consider briefly the modern evolutionary biologist Edward O. Wilson's explanation of how there can be meaning in life in (...) a naturalistic universe. Wilson is proposing that the meaning of life (human existence) is a matter of making sense of things. Lewis would have made clear that the fact that Wilson attempts to explain how there is meaning in life in a naturalistic universe confirms that he and we are beings who are committed to making sense of things. (shrink)

This revised edition includes a new Preface outlining developments in Relevance Theory since 1986, discussing the more serious criticisms of the theory, and ...

The authors demonstrate that unselfish behavior is in fact an important feature of both biological and human nature. Their book provides a panoramic view of altruism throughout the animal kingdom--from self-sacrificing parasites to the human capacity for selflessness--even as it explains the evolutionary sense of such behavior.

This paper outlines the main assumptions of relevance theory and points out some new directions for research. After discussing the nature of relevance and its role in communication and cognition, it assesses two alternative ways of drawing the explicit–implicit distinction, compares relevance theory’s approach to lexical pragmatics with those of Grice and neo-Griceans, and discusses the rationale for relevance theory’s conceptual–procedural distinction, reassessing the notion of procedural meaning in the light of recent research. It ends by looking briefly at the (...) relation between the capacity to understand a communicator’s meaning, on the one hand, and the capacity to assess her reliability and the reliability of the communicated content, on the other, and considers how these two capacities might interact. (shrink)

Mark Wilson presents a highly original and broad-ranging investigation of the way we get to grips with the world conceptually, and the way that philosophical problems commonly arise from this. He combines traditional philosophical concerns about human conceptual thinking with illuminating data derived from a large variety of fields including physics and applied mathematics, cognitive psychology, and linguistics. Wandering Significance offers abundant new insights and perspectives for philosophers of language, mind, and science, and will also reward the interest of (...) psychologists, linguists, and anyone curious about the mysterious ways in which useful language obtains its practical applicability. (shrink)

Biophilia is Edward O. Wilson's most personal book, an evocation of his own response to nature and an eloquent statement of the conservation ethic. Wilson argues that our natural affinity for life―biophilia―is the very essence of our humanity and binds us to all other living species.

Taking Hobbesian logic as my starting point, I argue that Hobbesian diffidence, one of the causes of quarrel in the state of nature, does not disappear once the citizens enter civil society. Rather, diffidence is merely contained by the sovereign. Following Alice Ristroph, I argue that diffidence comes to shape what citizens demand of the state/sovereign in the criminal law. However, I show that Ristroph does not fully appreciate that the concept of diffidence is a racialized one, and as such, (...) race underlies how the citizens understand their own diffidence, what citizens demand of the sovereign, and how they demand it. Further, because diffidence itself is racialized, criminal law need not make explicit appeals to race. Once racialized diffidence becomes embedded in the criminal law, it remains there regardless of any conscious racial animus. I show that racial profiling is a prime example of how this racialized diffidence manifests. Thus, I present Hobbesian diffidence as a framework from which to understand racial oppression. This paper is primarily an application of Hobbes to contemporary issues rather than an exegesis and analysis of Hobbes’s views. (shrink)

Mark Wilson explores our strategies for understanding the world. We frequently cannot reason about nature in the straightforward manner we anticipate, but must use alternative thought processes that reach useful answers in opaque and roundabout ways; and philosophy must find better descriptive tools to reflect this.

The evolutionary problem of the units of selection has elicited a good deal of conceptual work from philosophers. We review this work to determine where the issues now stand.

The central problem for pragmatics is that sentence meaning vastly underdetermines speaker’s meaning. The goal of pragmatics is to explain how the gap between sentence meaning and speaker’s meaning is bridged. This paper defends the broadly Gricean view that pragmatic interpretation is ultimately an exercise in mind-reading, involving the inferential attribution of intentions. We argue, however, that the interpretation process does not simply consist in applying general mind-reading abilities to a particular (communicative) domain. Rather, it involves a dedicated comprehension module, (...) with its own special principles and mechanisms. We show how such a metacommunicative module might have evolved, and what principles and mechanisms it might contain. (shrink)

Wilson et al. focus on one class of AGL tasks: the cognitively demanding task of detecting non‐adjacent dependencies (NADs) among items. They provide a typology of the different types of NADs in natural languages and in AGL tasks. A range of cues affect NAD learning, ranging from the variability and number of intervening elements to the presence of shared prosodic cues between the dependent items. These cues, important for humans to discover non‐adjacent dependencies, are also found to facilitate NAD (...) learning in several nonhuman animal species. (shrink)

"Mark Wilson aims to reconnect analytic philosophy with the evolving practicalities within science from which many of its grander concerns originally sprang. He offers an alternative history of how the subject might have developed had the insights of its philosopher/scientist forebears not been cast aside in the vain pursuit of 'ersatz rigor'"--.

Our main aim in this paper is to show that constructing an adequate theory of communication involves going beyond Grice’s notion of speaker’s meaning. After considering some of the difficulties raised by Grice’s three-clause definition of speaker’s meaning, we argue that the characterisation of ostensive communication introduced in relevance theory can provide a conceptually unified explanation of a much wider range of communicative acts than Grice was concerned with, including cases of both ‘showing that’ and ‘telling that’, and with both (...) determinate and indeterminate import. (shrink)

On the relevance-theoretic approach outlined in this paper, linguistic metaphors are not a natural kind, and ―metaphor‖ is not a theoretically important notion in the study of verbal communication. Metaphorical interpretations are arrived at in exactly the same way as literal, loose and hyperbolic interpretations: there is no mechanism specific to metaphors, and no interesting generalisation that applies only to them. In this paper, we defend this approach in detail by showing how the same inferential procedure applies to utterances at (...) both ends of the literal-loose-metaphorical continuum, and how both literal and metaphorical utterances may create poetic effects. (shrink)

Wilson outlines the basic principles of evolution with stories that entertain as much as they inform, and shows how, properly understood, these principles can illuminate the length and breadth of creation, from the origin of life to the nature of religion. Now everyone can move beyond the sterile debates about creationism and intelligent design to share Darwin's panoramic view of animal and human life, seamlessly connected to each other. Evolution, as Wilson explains, is not just about dinosaurs and (...) human origins, but about why all species behave as they do--from beetles that devour their own young, to bees that function as a collective brain, to dogs that are smarter in some respects than our closest ape relatives. And basic evolutionary principles are also the foundation for humanity's capacity for symbolic thought, culture, and morality.--From publisher description. (shrink)

These essays draw on work in the history and philosophy of science, the philosophy of mind and language, the development of concepts in children, conceptual..

We argue that the presence of a word in an utterance serves as starting point for a relevance guided inferential process that results in the construction of a contextually appropriate sense. The linguistically encoded sense of a word does not serve as its default interpretation. The cases where the contextually appropriate sense happens to be identical to this linguistic sense have no particular theoretical significance. We explore some of the consequences of this view. One of these consequences is that there (...) may be many more mentally represented concepts than there are linguistically encoded concepts. (shrink)

In his preface Mr Wilson writes 'I feel that a great many adults … would do better to spend less time in simply accepting the concepts of others uncritically, and more time in learning how to analyse concepts in general'. Mr Wilson starts by describing the techniques of conceptual analysis. He then gives examples of them in action by composing answers to specific questions and by criticism of quoted passages of argument. Chapter 3 sums up the importance of (...) this kind of mental activity. Chapter 4 presents selections for the reader to analyse, followed by questions of university entrance/scholarship type. This is a book to be worked through, in a sense a text-book. (shrink)

The Netherlands is one of the few countries where euthanasia is legal under strict conditions. This study investigates whether Dutch newspaper articles use the term ‘euthanasia’ according to the legal definition and determines what arguments for and against euthanasia they contain. We did an electronic search of seven Dutch national newspapers between January 2009 and May 2010 and conducted a content analysis. Of the 284 articles containing the term ‘euthanasia’, 24% referred to practices outside the scope of the law, mostly (...) relating to the forgoing of life-prolonging treatments and assistance in suicide by others than physicians. Of the articles with euthanasia as the main topic, 36% described euthanasia in the context of a terminally ill patient, 24% for older persons, 16% for persons with dementia, and 9% for persons with a psychiatric disorder. The most frequent arguments for euthanasia included the importance of self-determination and the fact that euthanasia contributes to a good death. The most frequent arguments opposing euthanasia were that suffering should instead be alleviated by better care, that providing euthanasia can be disturbing, and that society should protect the vulnerable. Of the newspaper articles, 24% uses the term ‘euthanasia’ for practices that are outside the scope of the euthanasia law. Typically, the more unusual cases are discussed. This might lead to misunderstandings between citizens and physicians. Despite the Dutch legalisation of euthanasia, the debate about its acceptability and boundaries is ongoing and both sides of the debate are clearly represented. (shrink)

The hypothesis of group selection fell victim to a seemingly devastating critique in 1960s evolutionary biology. In Unto Others (1998), we argue to the contrary, that group selection is a conceptually coherent and empirically well documented cause of evolution. We suggest, in addition, that it has been especially important in human evolution. In the second part of Unto Others, we consider the issue of psychological egoism and altruism -- do human beings have ultimate motives concerning the well-being of others? We (...) argue that previous psychological and philosophical work on this question has been inconclusive. We propose an evolutionary argument for the claim that human beings have altruistic ultimate motives. (shrink)

Recent research in ethics education shows a potentially problematic variation in content, curricular materials, and instruction. While ethics instruction is now widespread, studies have identified significant variation in both the goals and methods of ethics education, leaving researchers to conclude that many approaches may be inappropriately paired with goals that are unachievable. This paper speaks to these concerns by demonstrating the importance of aligning classroom-based assessments to clear ethical learning objectives in order to help students and instructors track their progress (...) toward meeting those objectives. Two studies at two different universities demonstrate the usefulness of classroom-based, formative assessments for improving the quality of students’ case responses in computational modeling and research ethics. (shrink)

There is a debate about whether particular properties are for Aristotle non-recurrent and trope-like individuals or recurrent universals. I argue that Physics I.7 provides evidence that he took non-substantial particulars to be neither; they are instead non-recurrent modes. Physics I.7 also helps show why this matters. Particular properties must be individual modes in order for Aristotle to preserve three key philosophical commitments: that objects of ordinary experience are primary substances, that primary substances undergo genuine change, and that primary substances are (...) ontologically fundamental. (shrink)

John Wilson; Does Equality (of Opportunity) Make Sense in Education?, Journal of Philosophy of Education, Volume 25, Issue 1, 30 May 2006, Pages 27–32, https://.

Following Jacques Hadamard, applied mathematicians typically investigate their models in the form of well-set problems, which actually consist of a family of applicational circumstances that vary in specific ways with respect to their initial and boundary values. The chief motive for investigating models in this wider manner is to avoid the improper behavioral conclusions one might reach from the consideration of a more restricted range of cases. Suitable specifications of the required initial and boundary variability typically appeal to previously established (...) experimental conclusions as to how the target system will behave under a range of eternally applied manipulations of the form “If the conditions pertaining to S were altered in manner M, internal features X would/would not alter”. In his investigations of causal reasoning within other parts of science, our first author has emphasized the conceptual importance of counterfactuals of this nature, for which he was been often criticized by authors of a self-styled “metaphysical” inclination. The purpose of this note is to argue, pace these objections, that closely analogous considerations have long been part of the practice of investigating differential equation models in a sensible way. (shrink)

John Wilson; Concepts, Contestability and the Philosophy of Education, Journal of Philosophy of Education, Volume 15, Issue 1, 30 May 2006, Pages 3–15, https://.

Chiappe and Kukla argue that relevance theory fails to solve the frame problem as defined by Fodor. They are right. They are wrong, however, to take Fodor’s frame problem too seriously. Fodor’s concerns, on the other hand, even though they are wrongly framed, are worth addressing. We argue that Relevance thoery helps address them.

George Wilson; Transparency and Twist in Narrative Fiction Film, The Journal of Aesthetics and Art Criticism, Volume 64, Issue 1, 8 March 2005, Pages 81–95, htt.

Gossip is a subject that has been studied by researchers from an array of disciplines with various foci and methods. We measured the content of language use by members of a competitive sports team across 18 months, integrating qualitative ethnographic methods with quantitative sampling and analysis. We hypothesized that the use of gossip will vary significantly depending on whether it is used for self-serving or group-serving purposes. Our results support a model of gossip derived from multilevel selection theory that expects (...) gossip to serve group-beneficial rules when rewards are partitioned at the group level on a scale that permits mutual monitoring. We integrate our case study with earlier studies of gossip conducted by anthropologists, psychologists, and management researchers. (shrink)

John Wilson; Relativism and Teaching, Journal of Philosophy of Education, Volume 20, Issue 1, 30 May 2006, Pages 89–96, https://doi.org/10.1111/j.1467-9752.1986.

In this paper I argue that Aristotle's understanding of mathematical continuity constrains the mathematical ontology he can consistently hold. On my reading, Aristotle can only be a mathematical abstractionist of a certain sort. To show this, I first present an analysis of Aristotle's notion of continuity by bringing together texts from his Metaphysica and Physica, to show that continuity is, for Aristotle, a certain kind of per se unity, and that upon this rests his distinction between continuity and contiguity. Next (...) I argue briefly that Aristotle intends for his discussion of continuity to apply to pure mathematical objects such as lines and figures, as well as to extended bodies. I show that this leads him to a difficulty, for it does not at first appear that the distinction between continuity and contiguity can be preserved for abstract mathematicals. Finally, I present a solution according to which Aristotle's understanding of continuity can only be saved if he holds a certain kind of mathematical ontology. (shrink)

Book reviewed in this article: Madness and the Criminal Law. By Norval Morris. The Insanity Plea: The Uses and Abuses of the Insanity Defense. By William J. Winslade and Judith Wilson Ross.

Recent discussions of genomics and international justice have adopted the concept of ‘global public goods’ to support both the view of genomics as a benefit and the sharing of genomics knowledge across nations. Such discussion relies on a particular interpretation of the global public goods argument, facilitated by the ambiguity of the concept itself. Our aim in this article is to demonstrate this by a close examination of the concept of global public goods with particular reference to its use in (...) the context of genomic databases. We contend that the argument for construing genomics as a global public good depends on seeing it as a natural good by focusing on features intrinsic to genomics knowledge. We shall argue that social and political arrangements are relevant and that recognising this opens the door to construing the use of global public goods language as a strategic one. (shrink)

Peer review is a widely accepted instrument for raising the quality of science. Peer review limits the enormous unstructured influx of information and the sheer amount of dubious data, which in its absence would plunge science into chaos. In particular, peer review offers the benefit of eliminating papers that suffer from poor craftsmanship or methodological shortcomings, especially in the experimental sciences. However, we believe that peer review is not always appropriate for the evaluation of controversial hypothetical science. We argue that (...) the process of peer review can be prone to bias towards ideas that affirm the prior convictions of reviewers and against innovation and radical new ideas. Innovative hypotheses are thus highly vulnerable to being “filtered out” or made to accord with conventional wisdom by the peer review process. Consequently, having introduced peer review, the Elsevier journal Medical Hypotheses may be unable to continue its tradition as a radical journal allowing discussion of improbable or unconventional ideas. Hence we conclude by asking the publisher to consider re-introducing the system of editorial review to Medical Hypotheses. (shrink)

John Wilson; Relativism and Teaching, Journal of Philosophy of Education, Volume 20, Issue 1, 30 May 2006, Pages 89–96, https://doi.org/10.1111/j.1467-9752.1986.

John Wilson, Barbara Cowell; The Democratic Myth, Journal of Philosophy of Education, Volume 17, Issue 1, 30 May 2006, Pages 111–117, https://doi.org/10.1111/j.

John Wilson; The Teaching Profession: a case of self-mutilation, Journal of Philosophy of Education, Volume 20, Issue 2, 30 May 2006, Pages 245–250, https://doi.

This article situates the analysis of fair-trade consumption in the context of debates about civic activism and political participation. It argues that fair-trade consumption should be understood as a political phenomenon, which, through the mediating action of organizations and campaigns, makes claims on states, corporations, and institutions. This argument is made by way of a case study of Traidcraft, a key player in the fair-trade movement in the United Kingdom. The study focuses on how Traidcraft approaches and enrolls its supporters.

What is the relationship between war propaganda and nationalism, and what are the effects of each on support for, or participation in, violent acts? This is an important question for international criminal law and ongoing speech crime trials, where prosecutors and judges continue to assert that there is a clear causal link between war propaganda, nationalism, and mass violence. Although most legal judgments hinge on the criminal intent of propagandists, the question of whether and to what extent propaganda and nationalism (...) interact to cause support for violence or participation remains unanswered. Our goal here is to contribute to research on propaganda and nationalism by bridging international criminal law and the behavioral and brain sciences. We develop an experiment conducted with Serbian participants that examines the effects of propaganda as identified in the latest international speech crime trial as causing mass violence, and thereby test hypotheses of expert witness Anthony Oberschall’s theory of mass manipulation. Using principal components analysis and Bayesian regression, we examine the effects of propaganda exposure and prior levels of nationalism as well as other demographics on support for violence, ingroup empathy, and outgroup empathy. Results show that while exposure to war propaganda does not increase justifications of violence, specific types of war propaganda increase ingroup empathy and decrease outgroup empathy. Further, although nationalism by itself is not significant for justifying violence, the interaction of increased nationalism and exposure to violent media is significant for altering group empathies. The implications of these findings are discussed with respect to international criminal law and the cognitive science of nationalism. (shrink)

The book situates the works and reception of the French scholar Pierre de la Ramée (Petrus Ramus) in a variety of European cultural and educational contexts, from Britain and France to Eastern Europe, from Germany to the Iberian peninsula, and from Scandinavia to the Netherlands. Pierre de la Ramée or Petrus Ramus (1515-1572) has long been a controversial figure in educational reform and innovation, from the moment of his first public academic statements in the 1530s, to his reception among scholars (...) in the twentieth and twenty-first centuries. What is beyond dispute, however, is the vast reach of his influence throughout Europe. Ramus's ideas were disseminated through copious editions and translations of his own textbooks, and in wave after wave of adaptations and re-imaginings of his ideas that swept across the continent. This volume embarks on a European tour of Ramism, using a wide range of previously unpublished or untranslated archival evidence from throughout the continent to examine the dissemination of Ramus's works and his intellectual influence in geographic and in disciplinary terms. The ten chapters explore the spread of Ramism from his home country of France to Protestant strongholds in Germany, Holland, and Britain, and in the Catholic context of the Iberian peninsula. The book also examines Ramism in the less familiar territories (to most Anglophone readers) of Scandinavia and Hungary, and considers the preceding and contemporary Dutch and German educational reform movements from which Ramus borrowed to forge his own distinctive intellectual method. (shrink)