Proponents of mechanistic explanations have recently proclaimed that all explanations in the neurosciences appeal to mechanisms. The purpose of the paper is to critically assess this statement and to develop an integrative account that connects a large range of both mechanistic and dynamical explanations. I develop and defend four theses about the relationship between dynamical and mechanistic explanations: that dynamical explanations are structurally grounded, that they are multiply realizable, possess realizing mechanisms and provide a powerful top-down heuristic. Four examples shall (...) support my points: the harmonic oscillator, the Haken–Kelso–Bunz model of bimanual coordination, the Watt governor and the Gierer–Meinhardt model of biological pattern formation. I also develop the picture of “horizontal” and “vertical” directions of explanations to illustrate the different perspectives of the dynamical and mechanistic approach as well as their potential integration by means of intersection points. (shrink)

Drawing on recent work in developmental and comparative psychology, this paper argues that demonstratives function to coordinate the interlocutors' joint focus of attention, which is one of the most basic functions of human communication. The communicative importance of demonstratives is reflected in a number of properties that together characterize them as a particular word class: In contrast to other closed-class expressions, demonstratives are universal, they are generally so old that their roots cannot be traced back to other linguistic items, they (...) are among the earliest words that children learn, and they are closely tied to a particular gesture. Moreover, demonstratives play an important role in the organization of discourse and the diachronic evolution of grammar, which arguably is also motivated by their communicative function to establish joint attention. (shrink)

Epigenetic modifications, such as DNA methylation and post‐translation modifications of histones, have been shown to play an important role in chromatin structure, promoter activity, and cellular reprogramming. Large protein complexes, such as Polycomb and trithorax, often harbor multiple activities which affect histone tail modification. Nevertheless, the mechanisms underlying the deposition of these marks, their propagation during cell replication, and the alteration on their distribution during transformation still require further study. Here we review recent data on those processes in both normal (...) and cancer cells, and we propose that the unscheduled expression of oncogenic transcription factors causes reprogramming of normal cells into cancer stem cells. (shrink)

The desideratum of semantic interoperability has been intensively discussed in medical informatics circles in recent years. Originally, experts assumed that this issue could be sufficiently addressed by insisting simply on the application of shared clinical terminologies or clinical information models. However, the use of the term ‘ontology’ has been steadily increasing more recently. We discuss criteria for distinguishing clinical ontologies from clinical terminologies and information models. Then, we briefly present the role clinical ontologies play in two multicentric research projects. Finally, (...) we discuss the interactions between these different kinds of knowledge representation artifacts and the stakeholders involved in developing interoperational real-world clinical applications. We provide ontology engineering examples from two EU-funded projects. (shrink)

ABSTRACT This paper explores the background to Mill’s feminist thought by relating his Subjection of Women to his early piece ‘On Marriage’ and three contemporary essays that were written among the radical Unitarian community of South Place Chapel by Harriet Taylor Mill, William Bridges Adams, and William Johnson Fox. It seeks to demonstrate that Mill’s Subjection of Women still has close ties with the earlier feminist thought of the South Place Chapel circle. Specifically, it will show that key arguments like (...) the characterisation of marriage as slavery, the pernicious moral effects of gendered education, and the social benefits of women’s liberation feature in the early essays by Mill himself, Harriet Taylor Mill, William Bridges Adams, and William Johnson Fox as well as in Mill’s Subjection. (shrink)

We aim to devise a Ramsey test analysis of actual causation. Our method is to define a strengthened Ramsey test for causal models. Unlike the accounts of Halpern and Pearl ([2005]) and Halpern ([2015]), the resulting analysis deals satisfactorily with both over- determination and conjunctive scenarios.

Janelle Pötzsch ABSTRACT: This paper discusses Mill’s early essay on marriage and divorce and gives two possible sources of influence for it: Plato’s arguments on the appropriate scope of the law in book IV of his Republic and Unitarian ideas on motherhood. It demonstrates that Plato’s Republic and Mill’s essay both emphasize the crucial ….

A simple explanation of theoreticity says that a term is theoretical if and only if it refers to nonobservational entities. Paradigmatic examples of such entities are electrons, neutrinos, gravitational forces, genes etc. There is yet another explanation of theoreticity: a theoretical term is one whose meaning becomes determined through the axioms of a scientific theory. The meaning of the term ‘force’, for example, is seen to be determined by Newton’s laws of motion and further laws about special forces, such as (...) the law of gravitation. Theoreticity is a property that is commonly applied to both expressions in the language of science, and referents and concepts of such expressions. Objects, relations and functions as well as concepts thereof may thus qualify as theoretical in a derived sense. (shrink)

Platonic Patterns is a reprint collection of many of Holger Thesleff's studies in Plato—spanning from 1967 to 2003. It includes three books, four articles and a new introduction by the author, which sets the general outline of his interpretation of Plato. Whereas much of the scholarship on Plato has tended to operate within the frame of one language and/or a single school of thought, Thesleff constructively combines several discoveries and theories of various scholars with his own research, focusing on (...) how Plato can be understood in his own context. The work represents small but significant breakthroughs in research on Plato from an internationally inclusive standpoint. Having previously been published mainly in Finland by scholarly societies, availability outside the Nordic countries has, up until now, been minimal. Thesleff employs his singular expertise of Greek language and literature to make innovative contributions to the study and interpretation of Plato. He thematically stresses the significance of the less overt elements found in Plato's dialogues, such as Plato's use of humor and his linguistic expression, while taking into account the chronology and/or the intended audience. (shrink)

In this paper, we analyse actual causation in terms of production. The latter concept is made precise by a strengthened Ramsey Test semantics of conditionals: \ iff, after suspending judgement about A and C, C is believed in the course of assuming A. This test allows us to verify or falsify that an event brings about another event. Complementing the concept of production by a weak condition of difference-making gives rise to a full-fledged analysis of causation.

In this paper, we propose a regularity theory of causation. The theory aims to be reductive and to align with our pre‐theoretic understanding of the causal relation. We show that our theory can account for a wide range of causal scenarios, including isomorphic scenarios, omissions, and scenarios which suggest that causation is not transitive.

This book aims to lay bare the logical foundations of tractable reasoning. It draws on Marvin Minsky's seminal work on frames, which has been highly influential in computer science and, to a lesser extent, in cognitive science. Only very few people have explored ideas about frames in logic, which is why the investigation in this book breaks new ground. The apparent intractability of dynamic, inferential reasoning is an unsolved problem in both cognitive science and logic-oriented artificial intelligence. By means of (...) a logical investigation of frames and frame concepts, Andreas devises a novel logic of tractable reasoning, called frame logic. Moreover, he devises a novel belief revision scheme, which is tractable for frame logic. These tractability results shed new light on our logical and cognitive means to carry out dynamic, inferential reasoning. Modularity remains central for tractability, and so the author sets forth a logical variant of the massive modularity hypothesis in cognitive science. (shrink)

Als Wissenschaftslogik bezeichnet Carnap jene Disziplin, welche die Nachfolge der traditionellen Philosophie im 20. Jahrhundert antreten sollte. Den zentralen Bezugspunkt von Carnaps wissenschaftslogischen Arbeiten bildet die von Frege und Russell entwickelte mathematische Logik. Dies gilt auch für die Zweistufenkonzeption, mit der Carnap ein allgemeines Schema zur Analyse der Bedeutung von Begriffen nichtmathematischer Theorien entwirft. Dabei wird die Abhängigkeit der begrifflichen Bedeutung von den Aussagen der jeweiligen Theorie explizit anerkannt, was eine Überwindung der Dogmen des Empirismus innerhalb des Logischen Empirismus einschlieβt. (...) Allerdings geht Carnap in seinen Arbeiten zur Semantik formaler Sprachen auf die spezifischen Eigenschaften von theoretischen Termen nicht ein, so daβ die Überwindung der Dogmen des Empirismus unvollständig bleibt. Darauf gründet sich die wesentliche Aufgabe der vorliegenden Untersuchung, welche darin besteht, die Deutung von theoretischen Termen durch Postulate im Rahmen der mathematischen Logik exakt zu beschreiben. (shrink)

This paper discloses the intellectual context of the feminist arguments English philosopher Harriet Taylor Mill (1807-1858) gives in her essay “Enfranchisement of Women” (1851). It will discuss to what extent Taylor Mill’s feminist views have been influenced by, and contributing to, Unitarianism and radical Unitarianism. My analysis of Taylor Mill’s essay focuses on three core aspects of the Unitarian tenet: its philosophy of history, its educational theory, and the “marriage as slavery”-trope of the radical Unitarians. I thereby provide an account (...) of the influences on Taylor Mill’s thought that are both separate from, and even predate her meeting with J.S. Mill. (shrink)

This book explores the rich philosophical content of the writings of Jonathan Swift. It discusses these philosophical topics against their ideengeschichtliche background and demonstrates that Swift’s work offers starting points for philosophical reflection that are still topical today.

The well-known formal semantics of conditionals due to Stalnaker Studies in logical theory, Blackwell, Oxford, 1968), Lewis, and Gärdenfors The logic and 1140 epistemology of scientific change, North-Holland, Amsterdam, 1978, Knowledge in flux, MIT Press, Cambridge, 1988) all fail to distinguish between trivially and nontrivially true indicative conditionals. This problem has been addressed by Rott :345–370, 1986) in terms of a strengthened Ramsey Test. In this paper, we refine Rott’s strengthened Ramsey Test and the corresponding analysis of explanatory relations. We (...) show that our final analysis captures the presumed asymmetry between explanans and explanandum much better than Rott’s original analysis. (shrink)

The well-known formal semantics of conditionals due to Stalnaker Studies in logical theory, Blackwell, Oxford, 1968), Lewis, and Gärdenfors The logic and 1140 epistemology of scientific change, North-Holland, Amsterdam, 1978, Knowledge in flux, MIT Press, Cambridge, 1988) all fail to distinguish between trivially and nontrivially true indicative conditionals. This problem has been addressed by Rott :345–370, 1986) in terms of a strengthened Ramsey Test. In this paper, we refine Rott’s strengthened Ramsey Test and the corresponding analysis of explanatory relations. We (...) show that our final analysis captures the presumed asymmetry between explanans and explanandum much better than Rott’s original analysis. (shrink)

In episode 6 of the first season of The Handmaid’s Tale, the Republic of Gilead welcomes a trade delegation of the United Mexican States. Offred’s hope that the ensuing trade agreement between Gilead and Mexico would eventually bring the sexual exploitation she and the other handmaids suffer to public are quickly dashed. During a chance encounter at the house of Offred’s master, the Mexican ambassador Mrs Castillo confides in Offred that Mexico is suffering a fertility crisis just like Gilead. Her (...) country is seriously considering trading with Gilead in handmaids. My article will use this episode as a starting point to reflect on the correlation between women’s social and economic status. I will illustrate how The Handmaid’s Tale demonstrates that markets are socially embedded and thereby reproduce and amplify social and political inequalities. This series thereby also functions as a powerful validation of the asymmetry thesis concerning markets in reproductive labour. (shrink)

A central topic in the logic of science concerns the proper semantic analysis of theoretical sentences, that is sentences containing theoretical terms. In this paper, we present a novel choice-semantical account of theoretical truth based on the epsilon-term definition of theoretical terms. Specifically, we develop two ways of specifying the truth conditions of theoretical statements in a choice functional semantics, each giving rise to a corresponding logic of such statements. In order to investigate the inferential strength of these logical systems, (...) we provide a translation of each truth definition into a modal definition of theoretical truth. Based on this, we show that the stronger notion of choice-semantical truth captures more adequately our informal semantic understanding of scientific statements. (shrink)

The paper provides a formal representation of goal systems. The focus is on three properties: consistency, conflict, and coherence. An aim is to attain conceptual clarity of these properties. It is argued that consistency is adequately regarded as a property relative to the decision situation or, more specifically, the set of alternatives that the agent faces. Moreover, as a condition of rationality, consistency is stronger than some writers have claimed. Conflict is adequately regarded as a relation over subsets of a (...) given goal system and should likewise be regarded as relative to the set of alternatives that the agent faces. Coherence is given a probabilistic interpretation, based on a support relation over subsets of goal systems. (shrink)

The present paper aims at a synthesis of belief revision theory with the Sneed formalism known as the structuralist theory of science. This synthesis is brought about by a dynamisation of classical structuralism, with an abductive inference rule and base generated revisions in the style of Rott (2001). The formalism of prioritised default logic (PDL) serves as the medium of the synthesis. Why seek to integrate the Sneed formalism into belief revision theory? With the hybrid system of the present investigation, (...) a substantial simplification of the ranking information that is necessary to define revisions and contractions uniquely is achieved. This system is, furthermore, expressive enough to capture complex and non-trivial scientific examples. It is thus closely related to a novel research area within belief revision theory which addresses the dynamics of scientific knowledge. (shrink)

Most recent accounts of personal autonomy acknowledge that the social environment a person lives in, and the personal relationships she entertains, have some impact on her autonomy. Two kinds of conceptualizing social conditions are traditionally distinguished in this regard: Causally relational accounts hold that certain relationships and social environments play a causal role for the development and on-going exercise of autonomy. Constitutively relational accounts, by contrast, claim that autonomy is at least partly constituted by a person’s social environment or standing. (...) The central aim of this paper is to raise the question how causally and constitutively relational approaches relate to the fact that we exercise our autonomy over time. I argue that once the temporal scope of autonomy is opened up, we need not only to think differently about the social dimension of autonomy. We also need to reconsider the very distinction between causally and constitutively relational accounts, because it is itself a synchronic (and not a diachronic) distinction. (shrink)

Are the houyhnhnms, the rational horses Gulliver meets in the fourth chapter of Jonathan Swift’s Gulliver’s Travels (1726), meant as role models for man? I think there are reasons to doubt this view. To illustrate this claim, I’ll compare Swift’s portrayal of the houyhnhnms with Immanuel Kant’s Groundwork to the Metaphysics of Morals (1785). There, Kant explicates that man is no ‘purely rational being’ but a ‘sensual rational being’. We’ll see that this characterization has tremendous consequences for the justification of (...) Kant’s moral principle. Similarly, Swift designates man as an animal rationis capax, i.e. an animal which is only capable of reasoning, but not wholly governed by it. Violations of moral norms are hence very likely to occur. Concluding, I shall argue that the houyhnhnms are no role-models because their morality runs counter to human nature. Instead, they serve to show that man adheres to an illusion. (shrink)

This paper offers a review of research on demonstratives from an interdisciplinary perspective. In particular, we consider the role of demonstratives in current research on language universals, language evolution, language acquisition, multimodal communication, signed language, language and perception, language in interaction, spatial imagery, and discourse processing. Traditionally, demonstratives are analyzed as a particular class of spatial deictics. Yet, a number of recent studies have argued that space is largely irrelevant to deixis and that demonstratives are primarily used for social and (...) interactive purposes. Synthesizing findings in the literature, we conclude that demonstratives are a very special class of linguistic items that are foundational to both spatial and social aspects of language and cognition. (shrink)