Forty years’ experience as a bacterial geneticist has taught me that bacteria possess many cognitive, computational and evolutionary capabilities unimaginable in the first six decades of the twentieth century. Analysis of cellular processes such as metabolism, regulation of protein synthesis, and DNA repair established that bacteria continually monitor their external and internal environments and compute functional outputs based on information provided by their sensory apparatus. Studies of genetic recombination, lysogeny, antibiotic resistance and my own work on transposable elements revealed multiple (...) widespread bacterial systems for mobilizing and engineering DNA molecules. Examination of colony development and organization led me to appreciate how extensive multicellular collaboration is among the majority of bacterial species. Contemporary research in many laboratories on cell–cell signaling, symbiosis and pathogenesis show that bacteria utilise sophisticated mechanisms for intercellular communication and even have the ability to commandeer the basic cell biology of ‘higher’ plants and animals to meet their own needs. This remarkable series of observations requires us to revise basic ideas about biological information processing and recognise that even the smallest cells are sentient beings. Previous article in issue. (shrink)

Forty years’ experience as a bacterial geneticist has taught me that bacteria possess many cognitive, computational and evolutionary capabilities unimaginable in the first six decades of the twentieth century. Analysis of cellular processes such as metabolism, regulation of protein synthesis, and DNA repair established that bacteria continually monitor their external and internal environments and compute functional outputs based on information provided by their sensory apparatus. Studies of genetic recombination, lysogeny, antibiotic resistance and my own work on transposable elements revealed multiple (...) widespread bacterial systems for mobilizing and engineering DNA molecules. Examination of colony development and organization led me to appreciate how extensive multicellular collaboration is among the majority of bacterial species. Contemporary research in many laboratories on cell–cell signaling, symbiosis and pathogenesis show that bacteria utilise sophisticated mechanisms for intercellular communication and even have the ability to commandeer the basic cell biology of ‘higher’ plants and animals to meet their own needs. This remarkable series of observations requires us to revise basic ideas about biological information processing and recognise that even the smallest cells are sentient beings. (shrink)

This paper copes with a real-world classification problem related to the management of claims received in an insurance company. The way to obtain the classifier is not easy due to the high amount of missing values as well as the inherent imbalanced scenario within class labels. Once the data partition has been done, the training set is submitted to an intensive double grid search in order to obtain the most promising type of missing value imputation approach and then a step (...) ahead is done using the best method and it starts the next round of data mining strategies which now falls into data rebalancing umbrella. Again, a grid search from an undersampling and oversampling family with different settings is done taking into account only seen data. The training data obtained after the first grid search are now submitted to the second step according the second grid search in order to get the ready training set for the further classifier training. The main objective of the work is to find the best combination of data mining techniques that suits the data set with a pipeline containing two types of data preparation methods coming from different families. As an outcome, first the problem of the presence of missing values has been addressed and then the data rebalancing techniques has been applied. The study focuses on obtaining classifiers based on Bayesian and lazy approaches as well as decision trees, evaluated on metrics such as the area under the ROC curve (AUC), Cohen’s kappa, Accuracy and the F-measure, among others. The imputation by the mean the mode is preferable to the Expectation Maximization Imputation in the scenario faced in this paper taking into account that the amount of missing values is higher than a forty percent for many features. (shrink)

The pathway from scientific knowledge (based on data, models, and forecasts) to societal implications and policy advice is a perilous one. The shift from "is" to "ought" may be slippery in terms of climate, biodiversity, regulations, and business. Yet, what is to be done if one's research discloses that fellow humans are unwittingly carrying out destructive actions on a large scale? If they are unaware of the dynamics within which they are (or are in danger of becoming) imprisoned, is there (...) then not an ethical obligation to respond beyond the scope of one's given role? This dilemma lies at the core of the issue of science-based activism, which the life and work of Jorgen Randers in many ways epitomizes. The best means of understanding science-based activism can be found in exploring Randers' steps, as this festschrift does. [Jorgen Randers (born 1945) co-authored The Limits to Growth in 1972 and its sequels in 1992 and 2004. He is a Professor of Climate Strategy at the Norwegian Business School in Oslo where he works on climate and energy issues, system dynamics, and green growth. Randers was President of the Norwegian Business School/BI 1981-89, and Deputy Director General of WWF International 1994-99. He chaired the Norwegian Commission on a Low-Emission Society which reported in 2006. In 2012, his work 2052 - A Global Forecast for the Next Forty Years was published.] [Subject: Science, Ethics, Environmental Studies]. (shrink)

This study’s objective was to understand Colombian adolescents’ experiences and preferences regarding access to sexual and reproductive health services (SRHS), either alone or accompanied. A mixed-method approach was used, involving a survey of 812 participants aged eleven to twenty-four years old and forty-five semi-structured interviews with participants aged fourteen to twenty-three. Previous research shows that adolescents prefer privacy when accessing SRHS and often do not want their parents involved. Such findings align with the longstanding tendency to frame the ethical principle (...) of autonomy as based on independence in decision-making. However, the present study shows that such a conceptualization and application of autonomy does not adequately explain Colombian adolescent participants’ preferences regarding access to SRHS. Participants shared a variety of preferences to access SRHS, with the majority of participants attaching great importance to having their parents involved, to varying degrees. What emerges is a more complex and non-homogenous conceptualization of autonomy that is not inherently grounded in independence from parental involvement in access to care. We thus argue that when developing policies involving adolescents, policymakers and health professionals should adopt a nuanced “relational autonomy” approach to better respect the myriad of preferences that Colombian (and other) adolescents may have regarding their access to SRHS. (shrink)

Keith Donnellan of UCLA is one of the founding fathers of contemporary philosophy of language, along with David Kaplan and Saul Kripke. Donnellan was and is an extremely creative thinker whose insights reached into metaphysics, action theory, the history of philosophy, and of course the philosophy of mind and language. This volume collects the best critical essays on Donnellan's forty-year body of work. The pieces by such noted philosophers as Tyler Burge, David Kaplan, and John Perry, discuss Donnellan's various insights (...) particularly offering new readings of his views on language and mind. (shrink)

When I cruise the forty-three television channels available to me (and that's basic cable), simultaneously being enchanted and disgusted by much that I see (a kind of Kantian sublime), I cannot help but think that the culture in which I find myself is less articulate than ever. For this situation perhaps the 43rd President of the United States could serve as a useful emblem—a joke that is all too easy to make. But such a diagnosis of the low standard of (...) my culture's literacy might also be too easy to make. For it is the case that America's traditional anti-intellectualism reaches new heights in our current, hypermediated milieu: we now have more venues than ever to disseminate undisciplined, uncreative thought (think, for example, of all the burgeoning blogs). On the other hand, such hypermediation amounts to an explosion of symbolization. Language is everywhere, and hence there is the demand to use it instrumentally well. Again, an image from the U.S. presidency is emblematic. Think of President Clinton's infamous line to the intrepid Independent Counsel: "It depends on what your definition of the word 'is' is." Such a line could represent the pervasive urge to absolutely precise articulation, controlling one's words to an extreme degree. Another emblem could be the common academic paper where a writer has masterfully summarized and explained the words of another thinker, rendering them more accessible but probably not more desirable. One could read this situation dialectically: the moment when concern for the value of language seems lowest is also the moment when the demand for controlling language is highest. Beyond dialectics, however, I take the demand for absolute articulation as a jumping-off point for considering an idea that might appear to have nothing to do with this implicit yet persistent demand—the concept of presence. More specifically, I want to consider how a particular rendering of this concept affects what we might call the divine and its relationship to an ostensibly secular culture, and I also want to consider some lines from Emerson and how they can lead one to think of the divine as presence, a presence that requires an absence, a presence that to some extent is an absence. According to this encounter with Emerson, thinking about the presence and absence of the divine has to do with the way one takes up writing. (shrink)

Abstract.Human altruistic behavior has received a great deal of scientific attention over the past forty years. Altruistic‐like behaviors found among insects and animals have illumined certain human behaviors, and the revival of interest in group selection has focused attention on how sacrificial altruism, although not adaptive for individuals, can be adaptive for groups. Curiously, at the same time that sociobiology has placed greater emphasis on the value of sacrificial altruism, Protestant ethics in America has moved away from it. While Roman (...) Catholic ethics has a longstanding tradition emphasizing an ordering of love, placing love of self second only to love for God, Protestant ethics in America has adopted a similar stance only recently, replacing a strong sacrificial ethic with one focusing on mutual regard for self and others. If sociobiology is correct about the significance of sacrificial altruistic behaviors for the survival of communities, this shift away from sacrificial agape by American Christianity may cut the community off from important resources for the development of a global ethic crucial for the survival of that faith community and humankind itself. (shrink)

Human altruistic behavior has received a great deal of scientific attention over the past forty years. Altruistic-like behaviors found among insects and animals have illumined certain human behaviors, and the revival of interest in group selection has focused attention on how sacrificial altruism, although not adaptive for individuals, can be adaptive for groups. Curiously, at the same time that sociobiology has placed greater emphasis on the value of sacrificial altruism, Protestant ethics in America has moved away from it. While Roman (...) Catholic ethics has a longstanding tradition emphasizing an ordering of love, placing love of self second only to love for God, Protestant ethics in America has adopted a similar stance only recently, replacing a strong sacrificial ethic with one focusing on mutual regard for self and others. If sociobiology is correct about the significance of sacrificial altruistic behaviors for the survival of communities, this shift away from sacrificial agape by American Christianity may cut the community off from important resources for the development of a global ethic crucial for the survival of that faith community and humankind itself. (shrink)

Forty‐nine subjects judged the relevancy of sentence parts of a word problem (the Allsports problem). Patterns of subjects' judgments suggest three problem‐solving heuristics: a SETS heuristic, a TIME heuristic, and a QUESTION heuristic. Presentation of the question before the problem tends to suppress SETS and TIME heuristics. A computer program (ATTEND) is presented to simulate subjects' behavior on the Allsports problem. The program is context‐sensitive in that it can change a relevance judgment upon the acquisition of further information. Averaged subject (...) judgments and ATTEND judgments agree for 87% of the items. (shrink)

The aim of this systematic review was to summarize and assess the quality of asthma intervention health economic studies from 2002 to 2007, compare the study findings with clinical management guidelines, and suggest avenues for future improvement of asthma health economic studies. Forty of the 177 studies met our inclusion criteria. We assessed the quality of studies using The Quality of Health Economic Studies validated instrument (total score range: 0-100). Six studies (15%) had quality category 2, 26 studies (65%) achieved (...) quality category 3, and the remaining eight (20%) studies were scored as the highest quality level, category 4. Overall, the findings from this review are in line with the Global Initiative for Asthma clinical guidelines. Many asthma health economic studies lacked appropriate long term time horizons to match the chronic nature of the disease and suffered from using effectiveness measures that did not capture all disease related risks and benefits. We recommend that new asthma simulation models: be flexible to allow for long term time horizons, focus on using levels of asthma control in their structure, and estimate both long term asthma specific outcomes like well-controlled time as well as generic outcomes such as quality adjusted survival. (shrink)

Graham Priest (1994) has argued that the following paradoxes all have the same structure: Russell’s Paradox, Burali-Forti’s Paradox, Mirimanoff’s Paradox, König’s Paradox, Berry’s Paradox, Richard’s Paradox, the Liar and Liar Chain Paradoxes, the Knower and Knower Chain Paradoxes, and the Heterological Paradox. Their common structure is given by Russell’s Schema: there is a property φ and function δ such that..

We were discussing the retirement age. Many of my colleagues said that of course existing interests must be preserved, but they had noticed that some of their colleagues had been past their prime by the time they reached 67, and that it would be a good thing if in future dons were retired at 65. I agreed, but pointed out that the argument went further. Quite a few of us were already deteriorating before they were 65. Nor was it clear (...) that 60 was the watershed. One could think of people who had finished their creative work by the time they were 55, indeed, by the time they were fifty. In fact some of us were already bores in our forties, and in so far as a large part of our raison d'etre was to teach the young, our ability to relate to them began to diminish in our thirties. The temperature dropped five degree with each five years, and in chilly silence the College moved on to Next Business. (shrink)

It is well-known that Immanuel Kant used Meier’s Excerpt from the Doctrine of Reason as a textbook in his logic lectures for almost forty years. Kant himself, and most later scholars, regard Meier as a follower of Wolff and Baumgarten; however, when we compare Meier’s Excerpt with Thomasius’ Introduction to the Doctrine of Reason, we find that Meier’s conception of “learned cognition” is derived from Thomasius’ conception of “learnedness.” Kant seems to have developed the pre-critical distinction between “the logic of (...) the common and healthy reason” and “the logic of the learned reason” from Meier’s distinction between “common” and “learned” cognition, which means that Meier’s appropriation of Thomasius also influenced Kant’s conception of logic. Connecting Kant’s views on logic to Thomasius through Meier in this way reveals that Kant’s pre-critical conception of logic was more eclectic than scholars have previously recognized. (shrink)

LANDSCAPING THE HUMAN SOUL In 1996 Lance Armstrong was diagnosed with stage-four testicular cancer. Doctors gave him a forty percent chance of survival. ...

Husserl's Original View on Phenomenological Psychology* JOSEPH J.KOCKELMANS Some forty years ago Edmund Husserl spoke publicly for the first time of a ...

Individuals with autistic spectrum disorder (ASD) display diverse deficits in social, cognitive and behavioral functioning. To date, there has been mixed findings on the profile of executive function deficits for high-functioning adults (IQ >70) with ASD. A conceptual distinction is commonly made between “cold” and “hot” executive functions. Cold executive functions refer to mechanistic higher-order cognitive operations (e.g., working memory), whereas hot executive functions entail cognitive abilities supported by emotional awareness and social perception (e.g., social cognition). This study aimed to (...) determine the independence of deficits in hot and cold executive functions for high-functioning adults with ASD. Forty-two adults with ASD (64% male, aged 18-66 years) and 40 age and gender matched controls were administered The Awareness of Social Inference Test (TASIT; emotion recognition and social inference), Letter Number Sequencing (working memory) and Hayling Sentence Completion Test (response initiation and suppression). Between-group analyses identified that the ASD group performed significantly worse than matched controls on all measures of cold and hot executive functions (d =.54-1.5). Hierarchical multiple regression analyses revealed that the ASD sample performed more poorly on emotion recognition and social inference tasks than matched controls after controlling for cold executive functions and employment status. The findings also indicated that the ability to recognise emotions and make social inferences was supported by working memory and response initiation and suppression processes. Overall, this study supports the distinction between hot and cold executive function impairments for adults with ASD. Moreover, it advances understanding of higher-order impairments underlying social interaction difficulties for this population which, in turn, may assist with diagnosis and inform intervention programs. (shrink)

This volume collects many of the major essays of feminist theory of the past forty years. The essays included here are those which have made key contributions to feminist theory during this period and which have generated extensive discussion. The volume organizes these essays historically, so as to provide a sense of the major turning points in feminist theory. Beginning with those essays which have provoked widespread discussion in the early days of the second wave, the volume then presents essays (...) which have been central to major discussions since that time. The essays present the complex relationship between feminism and Marxism, the second wave's "gynocentric turn," the theoretical elaboration of differences among women, and the essentialist debate, as these have occupied the attention of feminist theorists. Through this collection, the reader is able to gain a sense of the diverse directions feminist theory has taken over the past forty years, where feminist theory stands at the moment, and the questions which are just now beginning to emerge. (shrink)

Forty years ago, Vaughn Ball demonstrated that the then received notion of conditional relevance served no useful purpose, as it would only come into effect if the probability of an element were 0.0. But, if the probability of an element were 0.0, a directed verdict would be in order and so once again conditional relevancy was doing no work. I extended that analysis to include the relationship between proffers of evidence and facts of consequence to demonstrate that the work that (...) conditional relevancy was supposedly doing was isomorphic to that done by relevancy in all significant ways, and yet the Federal Rules of Evidence provide different standards for the two situations to determine admissibility. I thus proposed an amendment to FRE 104(b) to provide for the same standard to be applied to ‘relevancy’ and ‘conditional relevancy’. In a recent article, Matthew Kotzen appears to subject this work to intense scrutiny and criticism, yet at the same time reaches, so far as I can tell, identical conclusions. This raises the question, which I examine, whether this is an example of cross-disciplinary difficulties in communication. (shrink)

The past forty years or so have witnessed a renaissance in the philosophy of religion. New tools (modal logic, probability theory, and so on) and new historical research have prompted many thinkers to take a fresh look at old topics (God’s existence, the problem of evil, faith and reason, and the like). Moreover, sophisticated examinations of contentious new issues, such as the problem of religious diversity or the role of emotions and other non-evidential factors in shaping rationally held religious beliefs, (...) have also emerged. Addressing the need for an authoritative reference work to make sense of this rapidly growing and ever more complex corpus of scholarly literature, Philosophy of Religion is a new title in the Routledge Major Works series, Critical Concepts in Philosophy. Edited by a leading scholar, it is a four-volume collection which brings together key examples of the most important recent work, together with carefully selected historical pieces needed to understand them. Volume I focuses on concepts of the divine while Volume II explores arguments for and against the existence of a divine reality, with special attention to the problem of evil, the problem of divine hiddenness, and the case for naturalism. Volume III and the first part of Volume IV are devoted to broadly epistemic issues: the cognitive value of religious experience; the proper role of evidence in the formation of religious belief; the nature of justified religious belief; and pragmatic arguments for religious belief. The remainder of Volume IV introduces some of the best recent work on religious diversity, tolerance, and the public role of religion in a pluralistic society. The Philosophy of Religion is fully indexed and has a comprehensive introduction, newly written by the editor, which places the material in its historical and intellectual context. It is an essential work of reference and is destined to be valued by scholars and students as a vital one-stop research resource. Available now at a special introductory price. This price is applicable until 3 months after publication. For more information, please contact us ( [email protected] ). (shrink)

Some forty quite mediocre poems on philosophical subjects. For example: "My trouble is that I was born a slave/to Logic. What a mistress!! Harsh... Frigid... Rigid.../she is gigantique. 'gainst her I am a midget./she is almighty... I am her little knave./etc."--j. B.

On the translator's second visit to Dolpo in western Tibet he came across these four autobiographies of Tibetan lamas, three from the fifteenth century and one from the seventeenth century. Though the biographies appear superficially to be repetitious, they provide good insights into the lives of Tibetan holy men. Perhaps the most interesting part of the book, however, is the translator's introduction where he relates the story of his own journey to Dolpo and provides background material for the biographies. The (...) translator's own hardships in finding these texts in such a remote area give a good picture of life in the isolated areas of Tibet. For the Tibetan scholar there are indices of divinities, texts and rituals, personal names, and place names. The general index is followed by forty-five pages of black and white photographs of the area, the lamas, the art-work, etc. Last are two fold-out maps, one of Dolpo and the other of western and central Tibet.--P. J. H. (shrink)

A "book for edification and not of erudition," as the author puts it. Forty-one writers are represented in this collection, and the topics of the letters range from the devotional and exhortative to the every-day practical and familial.--P. J.

Jason Stanley argues in his new book that propaganda is more prevalent within liberal democracies - and is of far greater concern - than is typically assumed. Indeed, Stanley suggests that the very idea that propaganda only proliferates within authoritarian regimes, which have ministries set aside for its production, is a central tenet of the propaganda of the West. Stanley's aim in this book is to outline the distinctive features of propaganda within a liberal democracy. On his account, the 'flawed (...) ideology' of vested and powerful interest groups undermines the genuinely valuable ideals at the heart of the democratic project; this is what he refers to as 'demagogic propaganda'. Although I am highly sceptical of the argumentative strategies Stanley employs, the book raises significant issues about the extent to which public debates in countries like the United States and Australia involve distorted conceptions of what democratic principles properly entail. Criticisms of the undemocratic and illiberal nature of political processes within liberal democracies are of course common on the left. Two key features set Stanley's work apart from much of that literature. First, he regards democratic principles as genuinely valuable and does not dismiss them as 'mere reactionary claptrap', as many in the New Left did forty years ago. Second, and more significantly, his intellectual background is highly unusual. Stanley is an analytic philosopher whose training was primarily in epistemology and formal semantics rather than in social theory or political philosophy. This is uncommon, since most analytic philosophers who are focused on epistemology and similar issues avoid political questions, a reticence of which Stanley does not approve. Indeed, the book is driven, as he says, by a profound sense of regret that analytic philosophy has surrendered many of its central questions to sociology and social theory. (shrink)

The third book of Lucretius' great poem on the workings of the universe is devoted entirely to expounding the implications of Epicurus' dictum that death does not matter, 'is nothing to us'. The soul is not immortal: it no more exists after the dissolution of the body than it had done before its birth. Only if this fact is accepted can men rid themselves of irrational fears and achieve the state of ataraxia, freedom from mental disturbance, on which the Epicurean (...) definition of pleasure was based. To present this case Lucretius deploys the full range of poetic and rhetorical registers, soberly prohibitive, artfully decorative or passionately emotive as best suits his argument, reinforcing it with vivid and compelling imagery. This new edition has been completely revised, with a considerably enlarged Commentary and a new supplementary introduction taking account of the great amount of new scholarship of the last forty years. (shrink)

As the editors remark in their preface, the neglect of F. H. Bradley during the last forty years or so is partly due to the dearth of good secondary literature. This book amply rectifies this situation. Something like nineteenth-century idealism is once more in the air, as Dummett and his followers run together questions of truth with those of warranted assertability. H. H. Joachim talked horribly of something he called “truth-or-knowledge,” and in the end Bradley may not always have kept (...) the two things distinct. However, at least in the Principles of Logic Bradley did make the distinction clearly. See James Allard’s essay in the present volume, p. 180. (shrink)

Anyone who has worked in Science for forty years can be much surprised to realize how little he now hears about evolution, compared with such former times. At present, evolution seems to be accepted as an axiomatic or universal principle, while the mechanism of it is not much considered, except by a small group of specialists, who work on the subject in greatly limited ways. This is practically a reversal of the former emphasis. The chemist would probably suggest that the (...) change is due to a better realization of the chemical difficulties involved in the mechanics of evolution, and his own change in viewpoint. The chemical difficulties will have increased to an almost incredible degree in this period, and his viewpoint will have changed correspondingly. A glance at some of these changes should illuminate the progress made in both subjects in this period. (shrink)

Heidegger’s monumental Gesamtausgabe is divided into four parts. The first, from which the present book comes, will gather, in sixteen volumes, and annotate with Heidegger’s marginalia his already published works with the exception of his courses. The second part will present in some forty volumes his courses from 1923 through 1945. The third part will include some of his unpublished writings and conferences, while the fourth will be dedicated to notes and information on the works. The present work presents the (...) text of his 1950 collection of essays "unchanged"—with two exceptions. The text of the first entry, "The Origin of the Artwork," is that of the slightly revised "Reclam" edition; and, as in the previously published editions of Sein und Zeit and Wegmarken, certain "stylistic or clarificatory corrections from the hand of the author" are made in the text without notation. This practice corresponds to Heidegger’s own wishes to avoid distracting philological apparatus and to present an "Ausgabe letzter Hand.". (shrink)

OBJECTIVES: To review the characteristics and performance of research ethics committees in Spain in the evaluation of multicentre clinical trial drug protocols. DESIGN: A prospective study of 100 applications. SETTING: Forty-one committees reviewing clinical trial protocols, involving 50 hospitals in 25 cities. MAIN MEASURES: Protocol-related features, characteristics of research ethics committees and evaluation dynamics. RESULTS: The 100 applications involved 15 protocols (of which 12 were multinational) with 12 drugs. Committees met monthly (except one). They had a mean number of 12 (...) members, requested a mean of six complete dossiers and nine additional copies of the protocol with a mean deadline of 14 days before the meeting. All applications were approved except three (two of the three were open-label long-term safety trials rejected by the same committee), which were approved by the other committees involved. The mean time from submission to approval was 64 days. The mean time from submission to arrival of the approval document at our offices was 85 days. Twenty-five committees raised queries for 38 of the 97 finally approved applications. Impact of evaluation fee, number of members, queries raised and experience of committees on timings were not statistically significant. CONCLUSION: Obtaining ethical approval is time-consuming. There is much diversity in the research ethics committees' performance. A remarkable delay (> 20 days) exists between the decision and the arrival of the written approval, suggesting administrative or organisational problems. (shrink)

In 1853, two decades after Goethe’s death, Hermann von Helmholtz, who had just become professor of anatomy at Königsberg, delivered an evaluation of the poet=s contributions to science.1 The young Helmholtz lamented Goethe=s stubborn rejection of Newton =s prism experiments. Goethe=s theory of light and color simply broke on the rocks of his poetic genius. The tragedy, though, was not repeated in biological science. In Helmholtz=s estimation, Goethe had advanced in this area two singular and “uncommonly fruitful” ideas.2 The poet (...) recognized, first, that the anatomical structures of various kinds of animals revealed a unity type underlying the superficial differences arising from variability of food, habit, and locality. His second lasting achievement was the related theory of the metamorphosis of organisms: the thesis that the various articulations within an organism developed out of a more basic kind of structure—that, for instance, the different parts of plants were metamorphosed leaves or that the various bones of the animal skull were but transformed vertebrae. These two general morphological conceptions, according to Helmholtz, grounded the biology flourishing at 1 mid-century. Goethe came to these ideas, Helmholtz shrewdly maintained, as the result of a poetically intuitive conception.3 He described, for instance, Goethe=s immediate recognition, while playfully tossing around a sheep=s skull on the Lido in Venice, that the fused bones of the battered cranium consisted of transmuted vertebrae. This experience resulted in the poet=s vertebral theory of the skull, which became a standard conception in later morphology.4 Poetic intuition thus liberated an idea initially embedded in matter and made it available to the analytic understanding of the scientist. Forty years later, in 1892, at the meeting of the Goethe Society in Weimar, Helmholtz returned to reexamine the poet=s scientific accomplishments, and, it would seem, implicitly his own; for by the end of his career, Helmholtz himself had achieved a position in German culture only a few steps below that of Goethe.5 His evaluation of Goethe=s achievements in physical science was now more complex than his earlier assessment had been. (shrink)