The basis of science is the hypothetico-deductive method and the recording of experiments in sufficient detail to enable reproducibility. We report the development of Robot Scientist "Adam," which advances the automation of both. Adam has autonomously generated functional genomics hypotheses about the yeast Saccharomyces cerevisiae and experimentally tested these hypotheses by using laboratory automation. We have confirmed Adam's conclusions through manual experiments. To describe Adam's research, we have developed an ontology and logical language. The resulting formalization involves over 10,000 different (...) research units in a nested treelike structure, 10 levels deep, that relates the 6.6 million biomass measurements to their logical description. This formalization describes how a machine contributed to scientific knowledge. (shrink)
The proposition that feedback is never necessary in speech recognition is examined for utterances consisting of sequences of words. In running speech the features near word boundaries are often modified according to language-dependent rules. Application of these rules during word recognition requires top-down processing. Because isolated words are not usually modified by rules, their recognition could be achieved by bottom-up processing only.
As part of an ethics course, health professions students were asked to identify ethical issues and to propose resolutions before and after a class discussion of a case involving confidentiality and substance abuse. Students listed an average of 2.4 issues before and 3.6 issues after the discussion. After discussion 50 per cent of students made explicit changes in their proposed resolution. Opinions varied widely on breaching confidentiality and the responsibility for protecting the patient's health. After the discussion almost 20 per (...) cent of the class felt it was acceptable to breach confidentiality as long as the patient was unaware. Many students identified more with the health care provider than with the patient. The presence of substance abuse altered many students' views on confidentiality. In this experience students were less rigorous in their application of principles, creating an excellent opportunity for teaching through exploration of the complexity of ethical decision-making in a specific case. (shrink)
The requirements of the UK Equality Act 2010 and some high profile criticism for using a potentially ageist methodology have prompted the National Institute for Health and Clinical Excellence (NICE) to assess the processes and methodology it uses to make appraisal decisions. This paper argues that NICE has established rigorous systems to protect against ageist decisions, has no track record of ageism and is well placed to meet the requirements of new UK equality legislation.
Cet article esquisse un rapprochement entre un courant de pensée politique, le néoréalisme, et une méthode en sciences humaines, le structuralisme. Ce courant et cette méthode ont suivi des trajectoires séparées, de l’après-guerre à la fin des années soixante-dix, jusqu’à ce que Kenneth Waltz croise ces deux problématiques. Après avoir défini respectivement réalisme et structuralisme, cet article établit leur connexion et tente d’éclairer les raisons pour lesquelles ce rapprochement n’avait pas été conduit jusqu’alors.
La démocratie est certainement le fil conducteur de l’ensemble de l’œuvre – a priori épars – de l’économiste et philosophe Amartya Sen. D’une part, sa foi en la démocratie apparaît comme la raison première de sa volonté de défier le « théorème d’impossibilité » établi par Kenneth Arrow au début des années cinquante, et comme une ligne directrice dans sa recherche en théorie du choix social. D’autre part, dans ses analyses de problèmes sociaux plus empiriques, comme la famine ou (...) les inégalités.. (shrink)