BackgroundPreprint usage is growing rapidly in the life sciences; however, questions remain on the relative quality of preprints when compared to published articles. An objective dimension of quality that is readily measurable is completeness of reporting, as transparency can improve the reader’s ability to independently interpret data and reproduce findings.MethodsIn this observational study, we initially compared independent samples of articles published in bioRxiv and in PubMed-indexed journals in 2016 using a quality of reporting questionnaire. After that, we performed paired comparisons (...) between preprints from bioRxiv to their own peer-reviewed versions in journals.ResultsPeer-reviewed articles had, on average, higher quality of reporting than preprints, although the difference was small, with absolute differences of 5.0% [95% CI 1.4, 8.6] and 4.7% [95% CI 2.4, 7.0] of reported items in the independent samples and paired sample comparison, respectively. There were larger differences favoring peer-reviewed articles in subjective ratings of how clearly titles and abstracts presented the main findings and how easy it was to locate relevant reporting information. Changes in reporting from preprints to peer-reviewed versions did not correlate with the impact factor of the publication venue or with the time lag from bioRxiv to journal publication.ConclusionsOur results suggest that, on average, publication in a peer-reviewed journal is associated with improvement in quality of reporting. They also show that quality of reporting in preprints in the life sciences is within a similar range as that of peer-reviewed articles, albeit slightly lower on average, supporting the idea that preprints should be considered valid scientific contributions. (shrink)

Background: Clinical genomic implementation studies pose challenges for informed consent. Consent forms often include complex language and concepts, which can be a barrier to diverse enrollment, and these studies often blur traditional research-clinical boundaries. There is a move toward self-directed, web-based research enrollment, but more evidence is needed about how these enrollment approaches work in practice. In this study, we developed and evaluated a literacy-focused, web-based consent approach to support enrollment of diverse participants in an ongoing clinical genomic implementation study. (...) Methods: As part of the Cancer Health Assessments Reaching Many (CHARM) study, we developed a web-based consent approach that featured plain language, multimedia, and separate descriptions of clinical care and research activities. CHARM offered clinical exome sequencing to individuals at high risk of hereditary cancer. We interviewed CHARM participants about their reactions to the consent approach. We audio recorded, transcribed, and coded interviews using a deductively and inductively derived codebook. We reviewed coded excerpts as a team to identify overarching themes. Results: We conducted 32 interviews, including 12 (38%) in Spanish. Most (69%) enrolled without assistance from study staff, usually on a mobile phone. Those who completed enrollment in one day spent an average of 12 minutes on the consent portion. Interviewees found the information simple to read but comprehensive, were neutral to positive about the multimedia support, and identified increased access to testing in the study as the key difference from clinical care. Conclusions: This study showed that interviewees found our literacy-focused, web-based consent approach acceptable; did not distinguish the consent materials from other online study processes; and valued getting access to testing in the study. Overall, conducting empirical bioethics research in an ongoing clinical trial was useful to demonstrate the acceptability of our novel consent approach but posed practical challenges. (shrink)

This rich and varied collection of essays addresses some of the most fundamental human questions through the lenses of philosophy, literature, religion, politics, and theology. Peter Augustine Lawler and Dale McConkey have fashioned an interdisciplinary consideration of such perennial and enduring issues as the relationship between nature and history, nature and grace, reason and revelation, classical philosophy and Christianity, modernity and postmodernity, repentance and self-limitation, and philosophy and politics.

In lieu of an abstract, here is a brief excerpt of the content:Defending a Phenomenological–Behavioral Perspective: Culture, Behavior, and ExperienceMarino Pérez-Álvarez (bio), José M. García-Montes (bio), Adolfo J. Cangas (bio), and Louis A. Sass (bio)KeywordsBehavior, contextual phenomenology, culture, experienceWe should like to express our sincere thanks to all the authors for their commentaries on our articles. Given the restrictions of space (a limitation they too had to contend with), we can only respond to a few aspects of their interesting remarks. (...) We shall reply of course on the basis of our own approach—an approach that sets out to integrate culture, behavior, and experience, and that might be termed contextual phenomenology, phenomenological behaviorism, or perhaps most accurately (albeit more awkwardly), the phenomenological–behavioral perspective.In her commentary, Ibáñez-Guerra (2008), referring to the target articles “Phenomenology and behaviorism” (Pérez-Álvarez, Sass, and Cangas 2008) and “The role of superstition in psychopathology” (García-Montes et al. 2008), wonders whether our maintaining of the spirit of Skinner, as well as our recourse to phenomenology, might not themselves represent forms of superstitious behavior. She points out that it is not always a good idea to put new wine in old barrels. For her, the new wine and new barrels would be represented by social constructivism, of which she is reminded by some aspects of our work. But in making her own case, Ibáñez-Guerra (2008) reveals certain common prejudices concerning behaviorism, prejudices that have apparently persisted even after reading our article. Thus, for example, she does not see operant behavior as incorporating intentionality (what, in the target article, is presented in terms of final causality), because she assumes that intentionality would necessarily imply a mentalist and dualist notion involving a supposed internal mental entity that causes behavior. Skinner (1974) himself noted and rejected this very assumption in a passage that clearly distinguishes his own approach from what he calls a “stimulus-response formula”: “Possibly no charge,” he wrote,is more often leveled against behaviorism or a science of behavior than that it cannot deal with purpose or intention. A stimulus-response formula has no answer, but operant behavior is the very field of purpose and [End Page 281] intention. By its nature it is directed toward the future: a person acts in order that something will happen, and the order is temporal.(pp. 55–6)The place Skinner gives to intentionality and purpose is elaborated in our target article.Furthermore, Ibáñez-Guerra (2008) assumes that, on methodological grounds, Skinner rejects all that is not observable, or at least that cannot be operationalized. This, however, is simply incorrect, at least as regards Skinner’s radical behaviorism. As the reader may recall, radical (as opposed to methodological) behaviorism is neither operationalist nor does it reject private or subjective events because of their unobservability. Indeed, Skinner specifically acknowledges that such events are in fact observable—at least for one person: the subject him- or herself. The question for Skinner is to understand how the part of the world that is only observable and experiential for oneself is constructed or formed. In the end, it turns out that radical behaviorism is more radical, in the Aristotelian ontological sense (see Pérez-Alvarez, Sass, and García-Montes 2008), than post-modern constructionism. Indeed, as we remarked, radical behaviorism can still surprise us today. Similarly, phenomenology is starting to be missed in the clinical context (Andreasen 2007). We believe that radical behaviorism and phenomenology, mutually readjusted, are in fact excellent wines for the times we live in—if only we knew how to appreciate them.In their commentary on “Phenomenology and behaviorism: A mutual readjustment,” Fletcher and Hayes (2008) argue that the philosophy and theory of Acceptance and Commitment Therapy (ACT)/Relational Frame Theory (RFT) already contain the salutary aspects of phenomenology that we highlight in our target article. Their insistence on reducing the affinities we find between phenomenology and behaviorism to ACT/RFT consists, in our view, in a scientific–technical argument that is more scientistic than strictly philosophical in nature. Their insistence on the scientific–technical argument itself implies an unclarified philosophical assumption. On what grounds do experimental data constitute the last word? Has... (shrink)

' I heartily recommend it to any philosopher of language interested in the issues. [] Logicians, of course, will want to savour the whole thing.' Australian Journal of Philosophy, 71:3 (1993).

Various claims have been made, recently, that Darwin's argumentation in the Origin instantiates and so supports some general philosophical proposal about scientific theorizing, for example, the "semantic view". But these claims are grounded in various incorrect analyses of that argumentation. A summary is given here of an analysis defended at greater length in several papers by the present author. The historical and philosophical advantages of this analysis are explained briefly. Darwin's argument comprises three distinct evidential cases on behalf of natural (...) selection, cases, that is, for its existence, its adequacy and its responsibility. Theorizing, today, about evolution by natural selection involves a similar structure of evidential and explanatory concerns. (shrink)

This book is available either individually, or as part of the specially-priced Arguments of the Philosphers Collection.

These two texts are fundamental for the understanding not only of Neoplatonism but also of the conventions of biography in late antiquity. Neither has received such extensive annotation before in English, and this new commentary makes full use of recent scholarship. The long introduction is intended both as a beginner’s guide to Neoplatonism and as a survey of ancient biographical writing.

In this paper, I offer a view beyond that which would narrowly reduce the role of parents in medical decision making to acting as custodians of the best interests of children and toward an account of family authority and family autonomy. As a fundamental social unit, the good of the family is usually appreciated, at least in part, in terms of its ability successfully to instantiate its core moral and cultural understandings as well as to pass on such commitments to (...) future generations. The putative rights of children to expression, information, freedom of thought, conscience, religion, and to freedom of association with others are, in this essay, assessed from the perspective of those conditions necessary for the family to function as a moral community. In so doing, I respond to the move to liberate children from parental authority and to effect the transformation of the family as implied by the United Nations’ "Convention on the Rights of the Child" and the pediatric bioethics it supports. (shrink)

A (normal) system of propositional modal logic is said to be complete iff it is characterized by a class of (Kripke) frames. When we move to modal predicate logic the question of completeness can again be raised. It is not hard to prove that if a predicate modal logic is complete then it is characterized by the class of all frames for the propositional logic on which it is based. Nor is it hard to prove that if a propositional modal (...) logic is incomplete then so is the predicate logic based on it. But the interesting question is whether a complete propositional modal logic can have an incomplete extension. In 1967 Kripke announced the incompleteness of a predicate extension of S4. The purpose of the present article is to present several such systems. In the first group it is the systems with the Barcan Formula which are incomplete, while those without are complete. In the second group it is those without the Barcan formula which are incomplete, while those with the Barcan Formula are complete. But all these are based on propositional systems which are characterized by frames satisfying in each case a single first-order sentence. (shrink)

Truth of x (independently of any description of x) that it is f. A property f which holds of x but is not per se of x is said to hold per accidens of x. The essence of an individual is the sum of its per se properties. We can formulate the following: doctrine a: concrete individuals do not have essences though abstract entities do. Doctrine b: concrete individuals have essences but they do not individuate, whereas abstract entities have essences (...) which do individuate. Assumption i: we shall say that a thing exists insofar as it has an essence. Assumption ii: we shall say that we know a thing when we know what its per se properties are. We argue that plato held doctrine a and aristotle doctrine b (with assumptions i and ii). (edited). (shrink)

In an individualistic society and in the increasingly competitive business environment people do not seem inclined to forgive others their trespasses. One is more likely to choose to ignore the virtue of forgiveness as a way of handling personnel situations involving intense conflict or mild disagreements, favoring instead the negative feelings of resentment, anger, revenge or retaliation. Business people seem less concerned with growth in virtue and character; interestingly they allow their character and ultimately their work relationships to deteriorate because (...) they hold onto feelings of anger and resentment. Is there a place for forgiveness in our interpersonal relationships in general and in corporate life in particular? I believe there is. A study of the virtue of forgiveness shows that it is a misunderstood virtue, but one that deserves attention. In this article I will examine the virtue of forgiveness, defining what forgiveness is and is not, and will illustrate how it might be situated as an essential human resource management strategy. (shrink)

Although smallpox was declared eradicated in 1980, there are fears that stocks of the virus manufactured for military purposes by the Soviet Union may have fallen into the hands of “rogue nations” or terrorists. Worries about bioterrorism have thus sparked debate about whether or not the smallpox vaccine, which can be dangerous, should be offered to the general public. Meaningful public debate on this issue requires expert information about the likelihood that the virus will in fact be used as a (...) weapon. Informed voluntary individual decision making, about whether to get vaccinated if vaccine is made available to the public, would similarly require appreciation of the likelihood of attack. Public deliberation and private deliberation thus both require briefing by the intelligence community. (shrink)

It has become almost commonplace to recognise that teaching is an embodied practice. Most analyses of teaching as embodied practice focus on the embodied nature of the teacher as subject. Here, we use Butler's concept of performativity to analyse the reiterated acts that are intelligible as—performatively constitute—teaching, rather of the teacher as subject. We suggest that this simultaneously helps explain the persistence of teaching as a narrow repertoire of actions recognisable as ‘teaching’, and the policing of conformity to teaching thus (...) embodied. However, like performatively accomplished subjectivity, this repertoire is unstable and ambiguous, and thus open to change and disruption. Moreover, teacher subjectivities may lead them to mobilise these possibilities of disruption. (shrink)

The United Nations Educational, Scientific, and Cultural Organization's (UNESCO) Universal Declaration on Bioethics and Human Rights announces a significant array of welfare entitlements—to personal health and health care, medicine, nutrition, water, improved living conditions, environmental protection, and so forth—as well as corresponding governmental duties to provide for such public health measures, though the simple expedient of announcing that such entitlements are “basic human rights.” The Universal Declaration provides no argument for the legitimacy of the sweeping governmental authority, taxation, and regulation (...) to create and impose such “rights.” As this paper explores that some action promotes a purported good, such as “health,” does not thereby make the action morally permissible. Just as there are moral limits on legitimate personal actions, there are also moral limits on legitimate governmental actions to promote purported goods, including health. A core question of any governmental regulation, therefore, is whether it is a legitimate application of moral political authority or an unauthorized act of state coercion. Pace UNESCO's wide-ranging assertions, this paper argues that promoting health only falls within the legitimate authority of governments in very narrowly defined circumstances. As the paper critically explores, at stake are foundational moral and political questions concerning the limits of governmental authority to intervene in the consensual interaction of persons. Imposing such duties on others, including citizens of a state through regulatory activity and taxation, must be justified, nonarbitrary, and demonstrably within the limits of moral political authority. UNESCO's assertions do not meet this burden of proof. (shrink)

The issues surrounding ethical controversies in sport have filled the media recently. This book of invited original essays by mainstream philosophers as well as philosophers of sport will provide the reader with a discussion in ethics and sport based on a sound philosophical footing. It will be accessible to a wide range of teachers and students in the field of sport and leisure studies. Contributions from international, highly regarded experts in the fIeld provide the reader with systematic treatment of the (...) ethics of sport from a diverse perspective. (shrink)

In Book Γ of the Metaphysics Aristotle states and attempts to prove what he calls the basic principle of the science of being as being: the law of non‐contradiction. In this paper I defend an interpretation of his proof, inspired by Elizabeth Anscombe's 1961 essay in ‘Three Philosophers’, though some of its features were remarked on by Lukasiewicz in 1910, according to which Aristotle is proving this principle only for substance predicates, and that it is to be understood as the (...) basic principle of metaphysics rather than of logic. It is the principle that every substance has an essential nature, and if it is of the essential nature of x to be F then it cannot be of the essential nature of x to be not‐F since then x's being F and x's being not‐F would be the same. He puts it by saying that in such a case F and not‐F would ‘signify the same’ for x. Since they do not, x cannot be both. (shrink)

hoc est, Capitolium’. This sentence comes in a passage based on a portion of the Historia Regum Britanniae of Geoffrey of Monmouth, but is not itself to be found in Geoffrey. Since Luard was unable to find the words attributed to him ‘in Lucan’, he concluded that the chronicler who was responsible for their inclusion had made a mistake. He offers no suggestions about the origins of the quotation. In a posthumous work of G. Gundermann's edited by G. Goetz, Trogtis (...) und Gellius bei Radulfus de Diceto, we find the quotation described as ‘einen angeblichen Lucanvers'. W. Morel learned of its existence from this reference and printed it as fr. 12 of Lucan. (shrink)

Wishing to forestall an inquiry from Quinctius about the produce of his farm, Horace says that he will describe its forma et situs. What follows is not an impersonal description, but an account directed at Quinctius who is thought of as passing judgement on the farm. This involvement of Quinctius in the description must be extended to the protasis of the opening sentence of the description: continui montes si dissocientur opaca/valle…, temperiem laudes where the sense is something like ‘if you (...) were to find yourself in a place where the mountains, which crowd close to one another, are parted…, you would praise its temperate climate. (shrink)

Doctor and patient meet in a circle of feelings determined by suffering. Sensitivity to the suffering is an axis determining the nature of the doctor and patient relationship. The patient's experience of an illness is individual, private, and very often difficult to describe. But the possibility to understand the suffering of another person comes from the fact that suffering is a universal feeling. We propose to enter the world of patient's experience by writing a letter to a doctor, which would (...) reflect their experiences and expectations towards him. This was the task required for 120 students of the second year of medicine and dentistry education. (shrink)

When people hear the name of Cardinal Newman, one of the first associations they make is to his Idea of a University. However, it is rarely known that his first love was Catholic education at the elementary and secondary levels, so that the Oratory School he founded has been described as the “apple of his eye.” Interestingly, Pope Francis is the first pontiff in modern history, at least, to have taught high school (chemistry and Latin) and who has reflected extensively (...) on his own personal experiences of being raised by the Salesian Fathers in Argentina. Both Newman and Francis would regard Catholic elementary and secondary schools as essential to producing what Newman repeatedly referred to as “an educated laity” – equally essential for what St. John Paul II dubbed “the new evangelization.”. (shrink)

The Venerable John Henry Cardinal Newman seemingly had the “Midas touch” in reverse. Oxford, Littlemore, Dublin were all sites of failures; the “Achilli Affair” was a humiliation; the quarrel with Faber was an embarrassment. Nonetheless, most people today think of Newman as a rousing success story. Why? Newman serves as an object lesson in living the Paschal Mystery, whereby each moment of crisis can be transformed into a moment of grace.

In this paper I address the issue of the subject matter of linguistics. According to the prominent Chomskyan view, linguistics is the study of the language faculty, a component of the mind-brain, and is therefore a branch of cognitive psychology. In his recent book Ignorance of Language Michael Devitt attacks this psychologistic conception of linguistics. I argue that the prominent Chomskyan objections to Devitt's position are not decisive as they stand. However, Devitt's position should ultimately be rejected as there is (...) nothing outside of the mind of a typical speaker that could serve to fix determinate syntactic rules of her language or constitute the supervenience base of her connection to any such rules. (shrink)

In this paper my concern is to evaluate a particular answer to the question of how we acquire mastery of the syntax of our first language. According to this answer children learn syntax by means of scientific investigation. Alison Gopnik has recently championed this idea as an extension of what she calls the ‘theory theory’, a well established approach to cognitive development in developntental psychology. I will argue against this extension of the theory theory. The general thrust of my objection (...) is that at the point at which children are acquiring knowledge of syntax they are not in a position to engage in far-reaching scientific investigation. Or, if they are, there are no mechanisms in place to ensure that their scientific investigations will generate a common body of knowledge so making linguistic convergence a mystery. That this is so is a product of two salient features of scientific confirmation. I will conclude that my objections to the theory theory put pressure on learning theories in general. (shrink)

The following excerpt from Proclus' Commentary on the Timaeus appears as Fr. 37 in the edition of the fragments of Numenius by Des Places.1 It is the aim of this study to ascertain the original place of the fragment in his work, and to show that it belongs to a second-century school of allegorical commentary on the ancient theologians, and particularly on Pherecydes of Syros, of which Numenius will have been one of the brightest luminaries.

It has recently been suggested that, for Leibniz, temporal facts globally supervene on causal facts, with the result that worlds differing with respect to their causal facts can be indiscernible with respect to their temporal facts. Such an interpretation is at variance with more traditional readings of Leibniz's causal theory of time, which hold that Leibniz reduces temporal facts to causal facts. In this article, I argue against the global supervenience construal of Leibniz's philosophy of time. On the view of (...) Leibniz defended here, he adopts a non-modal reduction of time to events, a form of reductionism that entails a strong covariation between a world's temporal facts and its causal facts. Consequently, worlds discernible with respect to their temporal facts must be discernible with respect to their causal facts, and worlds discernible with respect to their causal facts must be discernible with respect to their temporal facts. This position strongly favors the standard identificatory reduction of time to causation often imputed to Leibniz. (shrink)

In the late seventies of the 20th century, Jacob Taubes, a philosopher of religion and a scholar in Jewish thought, visited Carl Schmitt in his home. Schmitt was a scholar in constitutional and international law who joined the Hitler regime in 1933. Both were fascinated by the apocalyptic tradition, albeit it in opposite ways. They had a conversation about the apostle Paul, especially about his ‘Letter to the Romans’. Their discussion focused on the passage in which Paul speaks of the (...) Jews as 'enemies of God'. Against the background of history’s violent anti-Semitism, this exceptional conversation deconstructs Paul’s texts, traditionally conceived as constitutive of orthodox Christianity, and opens them up for a more subversive, heterodox reading. By Taubes, Paul is portrayed as an heretic Jew who joined the ‘Jesus movement’. He remained loyal to his tradition, while at the same time searching for new forms of spiritual community, avoiding direct political actions, as well as Gnostic interiorization, and establishing a new Law. (shrink)