A twenty‐person working group convened to discuss the ethical and policy considerations of the controversial intervention called “growth attenuation,” and if possible to develop practical guidance for health professionals. A consensus proved elusive, but most of the members did reach a compromise.

The youth of Bentham (1776-1789).--The evolution of the utilitarian doctrine from 1789 to 1815.--Philosophic radicalism.

This work has been selected by scholars as being culturally important, and is part of the knowledge base of civilization as we know it. This work was reproduced from the original artifact, and remains as true to the original work as possible. Therefore, you will see the original copyright references, library stamps (as most of these works have been housed in our most important libraries around the world), and other notations in the work. This work is in the public domain (...) in the United States of America, and possibly other nations. Within the United States, you may freely copy and distribute this work, as no entity (individual or corporate) has a copyright on the body of the work. As a reproduction of a historical artifact, this work may contain missing or blurred pages, poor pictures, errant marks, etc. Scholars believe, and we concur, that this work is important enough to be preserved, reproduced, and made generally available to the public. We appreciate your support of the preservation process, and thank you for being an important part of keeping this knowledge alive and relevant. (shrink)

Explores the development of the ideas of evolutionary biology, particularly as affected by the increasing understanding of genetics and of the chemical basis of inheritance.

Richard Bradley and others endorse Reverse Bayesianism as the way to model awareness growth. I raise a problem for Reverse Bayesianism—at least for the general version that Bradley endorses—and argue that there is no plausible way to restrict the principle that will give us the right results. To get the right results, we need to pay attention to the attitudes that agents have towards propositions of which they are unaware. This raises more general questions about how awareness growth (...) should be modelled. (shrink)

This essay applies a plausible model for moral growth to examples of secular and religious children’s literature. The point is that moral maturation, given this model, requires imaginary worlds on both secular and religious presuppositions. Trying to guide a child’s reading toward either religious or secular books rather than toward good literature is shown therefore to miss the mark of good parenting.

It seems that whenever there is a struggle between cultures, the culture of the victorious people becomes the culture of the people as a whole in the beginning, but later on the culture of the subjugated people asserts itself and many of its essential elements have to be integrated in the elite culture. We can see this process at work in the making of the Indian civilization. In the beginning the culture of the newly triumphant Aryan hordes naturally became the (...) dominant culture of the Indian sub-continent. But later on the culture of the subjugated non-Aryans asserted itself, and during the second Brahmanical revival it found full-blooded expression in the Mahabharata, the Rāmāyana and the Puranas. As we shall see in this paper, even though the Aryans were conscious of the non-Aryan influence and resisted it, their attempts could not prevent copious inflow of non-Aryan culture. (shrink)

There is a crisis of valuation practices in the current academic life sciences, triggered by unsustainable growth and “hyper-competition.” Quantitative metrics in evaluating researchers are seen as replacing deeper considerations of the quality and novelty of work, as well as substantive care for the societal implications of research. Junior researchers are frequently mentioned as those most strongly affected by these dynamics. However, their own perceptions of these issues are much less frequently considered. This paper aims at contributing to a (...) better understanding of the interplay between how research is valued and how young researchers learn to live, work and produce knowledge within academia. We thus analyze how PhD students and postdocs in the Austrian life sciences ascribe worth to people, objects and practices as they talk about their own present and future lives in research. We draw on literature from the field of valuation studies and its interest in how actors refer to different forms of valuation to account for their actions. We explore how young researchers are socialized into different valuation practices in different stages of their growing into science. Introducing the concept of “regimes of valuation” we show that PhD students relate to a wider evaluative repertoire while postdocs base their decisions on one dominant regime of valuing research. In conclusion, we discuss the implications of these findings for the epistemic and social development of the life sciences, and for other scientific fields. (shrink)

Incremental implicit theories are associated with a belief regarding it is possible to improve one’s intelligence or ability through efforts. Previous studies have demonstrated that incremental implicit theories contributed to better academic achievement and positive youth development. Our study aimed to examine whether incremental implicit theories of morality significantly influenced change in students’ engagement in voluntary service activities. In our study, 54 Korean college students for Study 1 and 180 Korean 8th graders for Study 2 were recruited to conduct two (...) two-wave studies. We surveyed participants’ implicit theories of morality and participation in voluntary service activities. The effect of implicit theories of morality on change in service engagement was analyzed through regression analysis. In Study 1, the moral growth mindset significantly moderated longitudinal change in service engagement. In Study 2, the moral growth mindset significantly influenced engagement in art-related activities, while it significantly moderated change in engagement in youth-related activities. (shrink)

Children tend to produce words earlier when they are connected to a variety of other words along the phonological and semantic dimensions. Though these semantic and phonological connectivity effects have been extensively documented, little is known about their underlying developmental mechanism. One possibility is that learning is driven by lexical network growth where highly connected words in the child's early lexicon enable learning of similar words. Another possibility is that learning is driven by highly connected words in the external (...) learning environment, instead of highly connected words in the early internal lexicon. The present study tests both scenarios systematically in both the phonological and semantic domains across 10 languages. We show that phonological and semantic connectivity in the learning environment drives growth in both production‐ and comprehension‐based vocabularies, even controlling for word frequency and length. This pattern of findings suggests a word learning process where children harness their statistical learning abilities to detect and learn highly connected words in the learning environment. (shrink)

This work aims to study strategies used in Argentine local development experiences, focussing on industrial design, marketing and entrepreneurship. In order to this purpose, backgrounds are analysed with this approach adding the study of three strategic plans for national and provincial-level that are currently in force. With the analysis of the transport system in the last decade, an accelerated cost increase is evident, resulting in a relatively higher price of distributed products. This situation that was initially perceived as a disadvantage (...) finally set up an opportunity to produce locally. The goal of this paper is to provide tools that contribute to the work shipped by key institutions for local development (public, private and intermediary organisations), and the way these interact with the actors and the territory. In particular, the identification of productive sectors and the selection of goods that can be produced and consumed locally, as a key input for the formulation of projects. (shrink)

Against the scourge of the COVID-19 pandemic, college students’ learning engagement has become a key issue in universities and society. Guided by the theories of existential positive psychology and social perception, we explored the positive effect of a growth mindset on learning engagement during the COVID-19 pandemic. A total of 1,040 college students from universities in Henan Province of China effectively completed online questionnaires. The results showed that growth mindset was positively related to learning engagement and negatively associated (...) with perceived COVID-19 event strength and perceived stress; perceived COVID-19 event strength was positively related to perceived stress, while perceived COVID-19 event strength and perceived stress were negatively associated with learning engagement. Growth mindset affected learning engagement through three indirect paths: the mediating role of perceived COVID-19 event strength, the mediating role of perceived stress, and the serial mediating role of both perceived COVID-19 event strength and perceived stress. The results indicated that the growth mindset could contribute to college students’ learning engagement through the roles of perceived COVID-19 event strength and perceived stress during the COVID-19 pandemic. This study advances the understanding of the mechanism underlying the relationship between growth mindset and college students’ learning engagement during the COVID-19 pandemic. Furthermore, the findings of the study have important implications for promoting college students’ learning engagement during the pandemic. (shrink)

Awareness growth—coming to entertain propositions of which one was previously unaware—is a crucial aspect of epistemic thriving. And yet, it is widely believed that orthodox Bayesianism cannot accommodate this phenomenon, since that would require employing supposedly defective catch-all propositions. Orthodox Bayesianism, it is concluded, must be amended. In this paper, I show that this argument fails, and that, on the contrary, the orthodox version of Bayesianism is particularly well-suited to accommodate awareness growth. For it entails what I call (...) the refinement view, which allows us to capture that awareness growth consists in the increase of one’s capacity of discernment. (shrink)

In a case study of the growth of cognitive science, we analyzed the activities of the Cognitive Science Society with a particular emphasis on the multidisciplinary nature of the field. Analyses of departmental affiliations, training back‐grounds, research methodology, and paper citations suggest that the journal Cognitive Science and the Annual Meeting of the Cognitive Science Society are dominated by cognitive psychology and computer science, rather than being an equal division among the constituent disciplines of cognitive science. However, at many (...) levels, a growing percentage of work was found to involve a conjunction of multiple disciplines, such that approximately 30–50% of recent work in the Cognitive Science Society is multidisciplinary. In a questionnaire study of cognitive scientists involved in collaborative research, multidisciplinarity was found to shape the research process and affect the factors associated with successful research. (shrink)

This book draws its inspiration from Hilbert, Wittgenstein, Cavaillès and Lakatos and is designed to reconfigure contemporary philosophy of mathematics by making the growth of knowledge rather than its foundations central to the study of mathematical rationality, and by analyzing the notion of growth in historical as well as logical terms. Not a mere compendium of opinions, it is organised in dialogical forms, with each philosophical thesis answered by one or more historical case studies designed to support, complicate (...) or question it. The first part of the book examines the role of scientific theory and empirical fact in the growth of mathematical knowledge. The second examines the role of abstraction, analysis and axiomatization. The third raises the question of whether the growth of mathematical knowledge constitutes progress, and how progress may be understood. Readership: Students and scholars concerned with the history and philosophy of mathematics and the formal sciences. (shrink)

Two books have been particularly influential in contemporary philosophy of science: Karl R. Popper's Logic of Scientific Discovery, and Thomas S. Kuhn's Structure of Scientific Revolutions. Both agree upon the importance of revolutions in science, but differ about the role of criticism in science's revolutionary growth. This volume arose out of a symposium on Kuhn's work, with Popper in the chair, at an international colloquium held in London in 1965. The book begins with Kuhn's statement of his position followed (...) by seven essays offering criticism and analysis, and finally by Kuhn's reply. The book will interest senior undergraduates and graduate students of the philosophy and history of science, as well as professional philosophers, philosophically inclined scientists, and some psychologists and sociologists. (shrink)

This article argues that there is a fundamental contradiction between a profit-oriented economic system and long-term environmental sustainability. The ‘solutions’ that are proposed by mainstream environmental economists as well as their ‘ecological economy’ colleagues do not solve the central problems, but serve to further highlight the difficulties of changing capitalism towards sustainability. In a profit-oriented economy, capital accumulation is a prime driving force, and non-growth for the economy at large tends to result in serious economic and social crises. On (...) the other hand, a de-coupling of economic growth from resource depletion and environmental degradation is possible only within certain sectors or product types and within relatively short time perspectives. The assumptions of mainstream economists about infinite economic growth (and infinite dematerialisation) represent a false ontology according to which the powers and mechanisms of the natural world are considered totally controllable by humans as if they were mere epiphenomena of the human world. On the other hand, the assumptions of certain ecological economists about the possibility of steady-state capitalism disregard the relation between capital and surplus value, which constitutes a strong mechanism driving the capitalist economy toward limitless growth. (shrink)

키에르케고어에서 자아의 형성은 단지 논리나 사변(思辨)이 아니라 실제 생활에서 도덕적 성숙으로 정당화된다. 자아의 발견과 도덕적 성숙은 구체적 환경에서 살아가는 누구에게나 주어지는 책임이다. 이런 윤리적 책임은 단지 객관적 질문일 수 없고 각 개인이 자신의 실존(實存)에서 찾아야 한다.BR 실존과 사유를 예리하게 분석한 키에르케고어는 정교(精巧)한 사변에만 의존하는 인간이해를 받아들일 수 없었다. 키에르케고어에서 우리의 삶은 단지 합리적 탐색이나 지식과 정보의 축적이 아니라 아이러니, 실존적 불안, 실존적 절망을 체험하며 주체자로서 세계에 관계한다.BR 키에르케고어에서 진리는 구체적 생활을 통해 변증(辨證)된다. 그에게 실존적 의미에서 죄(罪) 혹은 잘못은 무지(無知)나 정보의 (...) 부족이 아니라 현실에 도달하지 못함을 뜻한다. 이런 점에서 잘못된 행동은 거짓을 따르며, 건덕(建德, edification) 즉 덕을 세우는 생활은 진실을 따르는 삶이다. (shrink)

A simple exogenous growth model gives conservative estimates of the economic implications of machine intelligence. Machines complement human labor when they become more productive at the jobs they perform, but machines also substitute for human labor by taking over human jobs. At first, expensive hardware and software does only the few jobs where computers have the strongest advantage over humans. Eventually, computers do most jobs. At first, complementary effects dominate, and human wages rise with computer productivity. But eventually substitution (...) can dominate, making wages fall as fast as computer prices now do. An intelligence population explosion makes per-intelligence consumption fall this fast, while economic growth rates rise by an order of magnitude or more. These results are robust to automating incrementally, and to distinguishing hardware, software, and human capital from other forms of capital. (shrink)

Robert Grosseteste was one of the most independent and vigorous Englishmen of the Middle Ages--a medieval Dr. Johnson in his powers of mind and personality. Of humble birth, he lived for many years in obscurity and emerged only late in life as a national figure, deeply conservative and profoundly critical of the contemporary world. As a scientist, theologian, and pastoral leader, he was rooted in an English tradition going back beyond the Norman Conquest. This comprehensive study of one of England's (...) great intellects by the late Sir Richard W. Southern of Oxford University is an important contribution to the history of ideas. (shrink)

Filtration combustion is described by Laplacian growth without surface tension. These equations have elegant analytical solutions that replace the complex integro-differential motion equations by simple differential equations of pole motion in a complex plane. The main problem with such a solution is the existence of finite time singularities. To prevent such singularities, nonzero surface tension is usually used. However, nonzero surface tension does not exist in filtration combustion, and this destroys the analytical solutions. However, a more elegant approach exists (...) for solving the problem. First, we can introduce a small amount of pole noise to the system. Second, for regularisation of the problem, we throw out all new poles that can produce a finite time singularity. It can be strictly proved that the asymptotic solution for such a system is a single finger. Moreover, the qualitative consideration demonstrates that a finger with 1 2 of the channel width is statistically stable. Therefore, all properties of such a solution are exactly the same as those of the solution with nonzero surface tension under numerical noise. The solution of the ST problem without surface tension is similar to the solution for the equation of cellular flames in the case of the combustion of gas mixtures. (shrink)

In this paper, we critique the emergent international normative framework of growth – the knowledge economy. We point out that the standardized character of knowledge economy's flagship – intellectual property rights (IPRs) – has an adverse impact on women in emerging economies, such as India. Conversely, this impact on women, a significant consumer segment, has a feedback effect in terms of market growth. Conceptually, we analyze the consequences of knowledge economy and standardized IPR through a feminist lens. We (...) extend the analyses by pointing to various contradictions surrounding growth norms; for example, there are inherent contradictions between established "formal" legalistic interpretation ofIPR, "soft law" norms of corporate social responsibility, a fluid situation of moral claims of human rights, and different institutional capabilities at the international and domestic level. Consequently, we are able to demonstrate how standard IPR laws fail to deliver equity for all. We argue our case through exploring the growth aspects of the agricultural sector in India and the adverse impact of standard biopatenting on women farmers' rights (as producers and consumers) and preservation of environment. We suggest that desired gendered equity is better achieved when there is a constellation of actors – private–sector business, the state, and civil-society leaders – working together to ensure a balanced development through tailoring of IPR to local needs. (shrink)

Many bilingual speakers believe they engage in different forms of thinking when they shift languages. This experience of entering different thought worlds can be explained with the hypothesis that languages induce different forms of `thinking-for-speaking'-- thinking generated, as Slobin (1987) says, because of the requirements of a linguistic code. "`Thinking for speaking' involves picking those characteristics that (a) fit some conceptualization of the event, and (b) are readily encodable in the language"[2] (p. 435). That languages differ in their thinking-for-speaking demands (...) is a version of the linguistic relativity hypothesis, the proposition that language influences thought and that different languages influence thought in different ways. (shrink)

Why does it seem better to be a pauper who becomes a king rather than a king who becomes a pauper even when each life contains an equivalent sum of goods to the other? Many argue that only the pauper-to-king life can be told as a redemption story and that it is good for you to live a redemption story. This paper calls that explanation into question and proposes an alternative: upward-trending lives reveal growth. I argue that growth (...) is a valuable feature of a life, that redemption is not, and that growth explains intuitions cited in favor of redemption. (shrink)

Political philosophy presents a static conception of childhood as a state of lack, a condition where intellectual, physical, and moral capacities are undeveloped. This view, referred to by David Kennedy as the deficit view of childhood, is problematic because it systematically disparages certain universal features of humanity—dependency and growth—and incorrectly characterizes them as features of childhood only. Thus there is a strict separation between childhood and adulthood because adults are characterized as fully autonomous agents who have reached the end (...) of their moral and cognitive development. I argue that this view is mistaken, and limits both the developmental abilities of adults and ongoing moral development within an organized state. I propose that we view dependency as a human condition. By doing so, children and adults form the kind of relationship with one another that encourages the growth and development of our moral sense in both childhood and adulthood. (shrink)

Research based on construal level theory (CLT) suggests that thinking about the distant future can prime people to solve problems by insight (i.e., an “aha” moment) while thinking about the near future can prime them to solve problems analytically. In this study, we used a novel method to elucidate the time-course of temporal priming effects on creative problem solving. Specifically, we used growth-curve analysis (GCA) to examine the time-course of priming while participants solved a series of brief verbal problems. (...) Participants were tested in two counterbalanced sessions in a within-subject experimental design; one session featured near-future priming and the other featured far-future priming. Our results suggest high-level construal may temporarily enhance analytical thinking; far-future priming caused transient facilitation of analytical solving while near-future priming induced weaker, transient facilitation of insightful solving. However, this effect is short-lived; priming produced no significant differences in the total number of insights and analytical solutions. Given the fleeting nature of these effects, future studies should consider implementing methodology that allows for aspects of the time-course of priming effects to be examined. A method such as GCA may reveal mild effects that would be otherwise missed using other types of analyses. (shrink)

The host of the growth of knowledge hallmarks, concocted by various philosophy of science models , is contemplated. It is enunciated that the most appropriate one is provided by methodology of scientific research programmes. Some salient drawbacks of the model, caused by the ambivalence of its basic notions, e.g. of the notions of ‘empirical content of a theory’, ‘progressive’ and ‘regressive’ ‘problemshifts’ can be mitigated by enriching the Lakatosian model with Nancy Cartwright’s results. To recapitulate: the genuine growth (...) of knowledge consists in the growth of causal explanations . -/- . (shrink)

Did protolanguage users use discrete words that referred to objects, actions, locations, etc., and then, at some point, combine them; or on the contrary did they have words that globally indexed whole semantic complexes, and then come to divide them? Our answer is: early humans were forming language units consisting of global and discrete dimensions of semiosis in dynamic opposition. These units of thinking-for-speaking, or ‘growth points’ (GPs) were, jointly, analog imagery (visuo-spatio-motoric) and categorically-contrastive (-emic) linguistic encodings. This discrete-global (...) duality was a new mode of embodied cognition that enabled thinking and acting in new ways: the dawn of protolanguage. Where did this mode of cognition come from? We have some suggestions based on the hypothesis that gestures gained the power to orchestrate actions, manual and vocal, with significances other than those of the actions themselves, giving rise to cognition framed in the proposed dual terms. Note, however, our proposal is not one of the ‘gesture-first’ theories of language origins. Such theories predict what did not evolve: a language of pantomime; rather than what did evolve: an integrated system of synchronized gestures and spoken forms. GP theory is an account of the cognition underlying such an integrated system. A scenario for the evolutionary selection of this cognitive mode is ‘Mead’s Loop’, a model in which one’s cognition is enriched by one’s own gestures, insofar as they are objects in social interactions. (shrink)

For most of the vast span of human history, economic growth was all but nonexistent. Then, about two centuries ago, some nations began to emerge from this epoch of economic stagnation, experiencing sustained economic growth that led to significant increases in standards of living and profoundly altered the level and distribution of wealth, population, education, and health across the globe. The question ever since has been--why? This is the first book to put forward a unified theory of economic (...) growth that accounts for the entire growth process, from the dawn of civilization to today. Oded Galor, who founded the field of unified growth theory, identifies the historical and prehistorical forces behind the differential transition timing from stagnation to growth and the emergence of income disparity around the world. Galor shows how the interaction between technological progress and population ultimately raised the importance of education in coping with the rapidly changing technological environment, brought about significant reduction in fertility rates, and enabled some economies to devote greater resources toward a steady increase in per capita income, paving the way for sustained economic growth. Presents a unified theory of economic growth from the dawn of civilization to today Explains the worldwide disparities in living standards and population we see today Provides a comprehensive overview of the three phases of the development process Analyzes the Malthusian theory and its empirical support Examines theories of demographic transition and their empirical significance Explores the interaction between economic development and human evolution. (shrink)

A twenty‐person working group convened to discuss the ethical and policy considerations of the controversial intervention called “growth attenuation,” and if possible to develop practical guidance for health professionals. A consensus proved elusive, but most of the members did reach a compromise.

This paper discusses how growth and aging became interrelated phenomena with the creation of gerontology in the United States. I first show that the relation of growth to senescence, which had hardly attracted scientific attention before the twentieth century, started to be investigated by several experimental scientists around the 1900s. Subsequently, research on the connection between the two phenomena entered a new domain through the birth of gerontology as a scientific field comprised of various disciplines, many of which (...) addressed growth. Due to gerontologists’ efforts, the association between aging and growth became stronger and more multifaceted within the discursive and organizational matrix constituting the new science, leading to a broader definition of senescence with an ambiguous connection to chronological age. Furthermore, as gerontologists borrowed the cultural agendas as well as research methods from studies of growth, aging began to be defined as a phenomenon that could be actively controlled and managed in both social arenas and laboratory environments. (shrink)

Transforming growth factor‐β (TGF‐β) and its related proteins regulate broad aspects of body development, including cell proliferation, differentiation, apoptosis and gene expression, in various organisms. Deregulated TGF‐β function has been causally implicated in the generation of human fibrotic disorders and in tumor progression. Nevertheless, the molecular mechanisms of TGF‐β action remained essentially unknown until recently. Here, we discuss recent progress in our understanding of the mechanism of TGF‐β signal transduction with respect to the regulation of gene expression, the control (...) of cell phenotype and the potential usage TGF‐β for the treatment of human diseases. (shrink)

The goal of this study was to examine the relationship between posttraumatic growth, ruminations, and core beliefs in grieving individuals after the loss of a loved one. The participants were 140 bereaved individuals (122 women, 18 men; M = 38.40; SD = 13.96). The results showed that posttraumatic growth was positively related to intrusive and deliberate ruminations; however, it was positively predicted only by deliberate ruminations. Core beliefs disruption was also positively related to deliberate and intrusive ruminations, but (...) only deliberate ruminations positively predicted core beliefs. Moreover, posttraumatic growth is positively related to grief after the loss but unrelated to the time elapsed since loss. Higher posttraumatic growth was found in individuals who had experienced a sudden loss and loss of a close family member. Overall, the study shows that deliberate ruminations, for example about the meaning of the loss and its consequences, can stimulate posttraumatic growth in bereaved individuals. (shrink)

Early humans formed language units consisting of global and discrete dimensions of semiosis in dynamic opposition, or ‘growth points.’ At some point, gestures gained the power to orchestrate actions, manual and vocal, with significances other than those of the actions themselves, giving rise to cognition framed in dual terms. However, our proposal emphasizes natural selection of joint gesture-speech, not ‘gesture-first’ in language origin.

This paper outlines a defense of scientific realism against the pessimistic meta- induction which appeals to the phenomenon of the exponential growth of science. Here, scientific realism is defined as the view that our current successful scientific theories are mostly approximately true, and pessimistic meta- induction is the argument that projects the occurrence of past refutations of successful theories to the present concluding that many or most current successful scientific theories are false. The defense starts with the observation that (...) at least 80% of all scientific work ever done has been done since 1950, proceeds with the claim that practically all of our most successful theories were entirely stable during that period of time, and concludes that the projection of refutations of successful theories to the present is unsound. In addition to this defense, the paper offers a framework through which scientific realism can be compared with two types of anti-realism. The framework is also of help to examine the relationships between these three positions and the three main arguments offered respectively in their support. (shrink)

Robert Higgs's Crisis and Leviathan argues that there is a ratchet effect both after major wars and other serious crises, such as depressions: attitudinal or ideological changes lead not only to greater government spending but greater intrusion of government into economic command and control. Higgs's explanation of the growth of government, however, is embedded in and driven by a particular ideological view of the legal‐economic world, one that misapprehends certain legal‐economic fundamentals, including the scope of economic command and control, (...) and that fails to deal with certain interpretive complexities, including alternative explanations. (shrink)

Before a cell divides into two daughter cells, it typically doubles not only its DNA, but also its mass. Numerous studies in cells ranging from yeast to mammals have shown that cellular growth, stimulated by nutrients and/or growth factor signaling, is a prerequisite for cell cycle progression in most types of cells. The textbook view of growth‐regulated cell cycles is that growth signaling activates the transcription of G1 Cyclin genes to induce cell proliferation, and also stimulates (...) anabolic metabolism and cell growth in parallel. However, genetic knockout tests in model organisms indicate that this is not the whole story, and new studies show that additional, “smarter” mechanisms help to coordinate the cell cycle with growth itself. Here we summarize recent advances in this field, and discuss current models in which growth signaling regulates cell proliferation by targeting core cell cycle regulators via non‐transcriptional mechanisms. (shrink)

This dissertation defends an ideal of democratic citizenship inspired by John Dewey’s theory of human flourishing, or “growth.” In its emphasis on the interrelatedness of individual development and social progress, Deweyan growth orients us toward a morally substantive approach to addressing the important question of how diverse citizens can live together well. I argue, however, that Dewey’s understanding of growth as a process by which conflicting interests, beliefs, and values are integrated into a more unified whole—both within (...) the community and within the self—is inadequate to the radical pluralism characteristic of contemporary liberal democratic societies. Given the pragmatist insight into the crucial role of socialization in identity formation, the problem with conceptualizing the ideal self as an integrated unity is that, for many, the complexity and diversity of our social world presents an insuperable obstacle to sustaining a unified (or always unifying) self. Most of us have multiple “selves” forged by the various groups with whom we identify and the often incongruous roles we play in our personal, professional, and/or public lives. Hence I offer a reconstruction of Deweyan growth that accounts for persistent yet positively valued diversity, both within the self and within the community. On the view I urge, which draws on the work of neopragmatist Richard Rorty and Chicana feminist Gloria Anzaldua, divisions within the self and between citizens are not merely problems always to be overcome, but potential resources for creating a stronger, more inclusive democracy. (shrink)

The developing mammalian heart responds to a variety of conditions, including changes in nutrient availability, blood oxygenation, hemodynamics, or tissue homeostasis, with impressive growth plasticity. This ensures the formation of a functional and normal sized organ by birth. During embryonic and fetal development the heart is exposed to various physiological and potentially pathological changes in the intrauterine environment which dramatically impact on normal cardiac function, tissue composition, and morphology. This paper summarizes the mechanisms employed by the embryonic and fetal (...) heart to adapt to various intrauterine challenges to prevent or minimize postnatal consequences of impaired cardiac development. Future investigations of this growth plasticity might lead to new therapeutic strategies for the prevention of cardiac disease in postnatal life. (shrink)

This study aimed to investigate the relationship of employee growth mindset with innovative behavior and the mediating role of use of strength as well as the moderating role of strengths-based leadership in this relationship. Data with a sample of 244 employees working in diverse Chinese organizations were collected at two points in time. Results of bootstrapping analyses demonstrated that growth mindset is positively related to innovative behavior, employee strengths use partially mediates the positive relationship of growth mindset (...) with innovative behavior, and strengths-based leadership strengthens the direct relationship between employee growth mindset and innovative behavior and the indirect relationship of employee growth mindset with innovative behavior via strengths use. This study advances growth mindset and innovative behavior theories and research. (shrink)

The aim of this paper is to trace how a perverted understanding of the human – of human nature, growth, and well-being – came to form the foundation for classical liberal economic thought and to identify some of the negative consequences of this development. My suggestion is that, in response to the social upheaval of the 16th, 17th, and 18th centuries that would lead to the rise of capitalism and make possible the industrial revolution, moral philosophers applied to humans (...) and to human society mechanistic principles from the highly successful natural sciences in an effort to make sense of a social world that had ceased to make sense. Thus emerged the impoverished view of the human that lies at the foundation of mainstream economic thinking: homo economicus – the human as a rational, utility-optimizing machine, driven by unlimited desires. (shrink)

This article argues that there is a fundamental contradiction between a profit-oriented economic system and long-term environmental sustainability. The `solutions' that are proposed by mainstream environmental economists as well as their `ecological economy' colleagues do not solve the central problems, but serve to further highlight the difficulties of changing capitalism towards sustainability. In a profit-oriented economy, capital accumulation is a prime driving force, and non-growth for the economy at large tends to result in serious economic and social crises. On (...) the other hand, a de-coupling of economic growth from resource depletion and environmental degradation is possible only within certain sectors or product types and within relatively short time perspectives. The assumptions of mainstream economists about infinite economic growth (and infinite dematerialisation) represent a false ontology according to which the powers and mechanisms of the natural world are considered totally controllable by humans as if they were mere epiphenomena of the human world. On the other hand, the assumptions of certain ecological economists about the possibility of steady-state capitalism disregard the relation between capital and surplus value, which constitutes a strong mechanism driving the capitalist economy toward limitless growth. (shrink)

In his book The Value of Science Poincaré criticizes a certain view on the growth of mathematical knowledge: “The advance of science is not comparable to the changes of a city, where old edifices are pitilessly torn down to give place to new ones, but to the continuous evolution of zoological types which develop ceaselessly and end by becoming unrecognizable to the common sight, but where an expert eye finds always traces of the prior work of the centuries past” (...) (Poincaré 1958, p. 14). The view criticized by Poincaré corresponds to Frege’s idea that the development of mathematics can be described as an activity of system building, where each system is supposed to provide a complete representation for a certain mathematical field and must be pitilessly torn down whenever it fails to achieve such an aim. All facts concerning any mathematical field must be fully organized in a given system because “in mathematics we must always strive after a system that is complete in itself” (Frege 1979, p. 279). Frege is aware that systems introduce rigidity and are in conflict with the actual development of mathematics because “in history we have development; a system is static”, but he sticks to the view that “science only comes to fruition in a system” because “only through a system can we achieve complete clarity and order” (Frege 1979, p. 242). He even goes so far as saying that “no science can be so enveloped in obscurity as mathematics, if it fails to construct a system” (Frege 1979, p. 242). By ‘system’ Frege means ‘axiomatic system’. In his view, in mathematics we cannot rest content with the fact that “we are convinced of something, but we must strive to obtain a clear insight into the network of inferences that support our conviction”, that is, to find “what the primitive truths are”, because “only in this way can a system be constructed” (Frege 1979, p. 205). The primitive truths are the principles of the axiomatic system. Frege’s stress on the role of systems also determines his views on the growth of mathematical knowledge.. (shrink)

In the specialized area of pediatric endocrinology, the use of human growth hormone (hGH) both for children who have a growth hormone abnormality and for the treatment of non-hGH-deficient children who are short is a current clinical reality that raises important ethical questions. Generally speaking, the use of hGH for those children who are clearly lacking it is an efficacious intervention based upon established clinical criteria. The use of hGH for children who are short, but have no (...) class='Hi'>growth hormone abnormality is ethically and clinically more controversial. The moral conundrum of how to gain knowledge about new medical treatments that may be beneficial to children while, at the same time, ethically enrolling them in clinical trials with placebo arms in order to gain such knowledge will continue to be a contentious issue in the conduct of research and in the delivery of health care. In addition, there are questions about what ought to be studied and whether a physical characteristic such as short stature ought to be viewed as a circumstance of less than optimal health. (shrink)

Trees architectural study shows gradients in the meristematic activity. This activity is described by the number of internodes per growth unit, which is considered as the output of a dynamic random process. Several species were observed, which led us to propose and then estimate some mathematical models. Computing the functioning of a tree in a given environment therefore involves finding the probability function of the meristems and following the evolution of the parameters of this law along the botanical gradients (...) (order, trend, acrotony) within its architecture. (shrink)