Living systems employ several mechanisms and behaviors to achieve robustness and maintain themselves under changing internal and external conditions. Regulation stands out from them as a specific form of higher-order control, exerted over the basic regime responsible for the production and maintenance of the organism, and provides the system with the capacity to act on its own constitutive dynamics. It consists in the capability to selectively shift between different available regimes of self-production and self-maintenance in response to specific signals and (...) perturbations, due to the action of a dedicated subsystem which is operationally distinct from the regulated ones. The role of regulation, however, is not exhausted by its contribution to maintain a living system’s viability. While enhancing robustness, regulatory mechanisms play a fundamental role in the realization of an autonomous biological organization. Specifically, they are at the basis of the remarkable integration of biological systems, insofar as they coordinate and modulate the activity of distinct functional subsystems. Moreover, by implementing complex and hierarchically organized control architectures, they allow for an increase in structural and organizational complexity while minimizing fragility. Finally, they endow living systems, from their most basic unicellular instances, with the capability to control their own internal dynamics to adaptively respond to specific features of their interaction with the environment, thus providing the basis for the emergence of minimal forms of cognition. (shrink)

Living systems employ several mechanisms and behaviors to achieve robustness and maintain themselves under changing internal and external conditions. Regulation stands out from them as a specific form of higher-order control, exerted over the basic regime responsible for the production and maintenance of the organism, and provides the system with the capacity to act on its own constitutive dynamics. It consists in the capability to selectively shift between different available regimes of self-production and self-maintenance in response to specific signals and (...) perturbations, due to the action of a dedicated subsystem which is operationally distinct from the regulated ones. The role of regulation, however, is not exhausted by its contribution to maintain a living system’s viability. While enhancing robustness, regulatory mechanisms play a fundamental role in the realization of an autonomous biological organization. Specifically, they are at the basis of the remarkable integration of biological systems, insofar as they coordinate and modulate the activity of distinct functional subsystems. Moreover, by implementing complex and hierarchically organized control architectures, they allow for an increase in structural and organizational complexity while minimizing fragility. Finally, they endow living systems, from their most basic unicellular instances, with the capability to control their own internal dynamics to adaptively respond to specific features of their interaction with the environment, thus providing the basis for the emergence of minimal forms of cognition. (shrink)

We have achieved a residue‐level resolution of genetic interaction mapping – a technique that measures how the function of one gene is affected by the alteration of a second gene – by analyzing point mutations. Here, we describe how to interpret point mutant genetic interactions, and outline key applications for the approach, including interrogation of protein interaction interfaces and active sites, and examination of post‐translational modifications. Genetic interaction analysis has proven effective for characterizing cellular processes; however, to date, systematic (...) high‐throughput genetic interaction screens have relied on gene deletions or knockdowns, which limits the resolution of gene function analysis and poses problems for multifunctional genes. Our point mutant approach addresses these issues, and further provides a tool for in vivo structure‐function analysis that complements traditional biophysical methods. We also discuss the potential for genetic interaction mapping of point mutations in human cells and its application to personalized medicine. (shrink)

Objective Manic and depressive phases of bipolar disorder (BD) show opposite psychomotor symptoms. Neuronally, these may depend on altered relationships between sensorimotor network (SMN) and subcortical structures. The study aimed to investigate the functional relationships of SMN with substantia nigra (SN) and raphe nuclei (RN) via subcortical-cortical loops, and their alteration in bipolar mania and depression, as characterized by psychomotor excitation and inhibition. -/- Method In this resting-state functional magnetic resonance imaging (fMRI) study on healthy (n = 67) and BD (...) patients (n = 100), (1) functional connectivity (FC) between thalamus and SMN was calculated and correlated with FC from SN or RN to basal ganglia (BG)/thalamus in healthy; (2) using an a-priori-driven approach, thalamus-SMN FC, SN-BG/thalamus FC, and RN-BG/thalamus FC were compared between healthy and BD, focusing on manic (n = 34) and inhibited depressed (n = 21) patients. -/- Results (1) In healthy, the thalamus-SMN FC showed a quadratic correlation with SN-BG/thalamus FC and a linear negative correlation with RN-BG/thalamus FC. Accordingly, the SN-related FC appears to enable the thalamus-SMN coupling, while the RN-related FC affects it favoring anti-correlation. (2) In BD, mania showed an increase in thalamus-SMN FC toward positive values (ie, thalamus-SMN abnormal coupling) paralleled by reduction of RN-BG/thalamus FC. By contrast, inhibited depression showed a decrease in thalamus-SMN FC toward around-zero values (ie, thalamus-SMN disconnection) paralleled by reduction of SN-BG/thalamus FC (and RN-BG/thalamus FC). The results were replicated in independent HC and BD datasets. -/- Conclusions These findings suggest an abnormal relationship of SMN with neurotransmitters-related areas via subcortical-cortical loops in mania and inhibited depression, finally resulting in psychomotor alterations. (shrink)

This paper puts forward an account of blame combining two ideas that are usually set up against each other: that blame performs an important function, and that blame is justified by the moral reasons making people blameworthy rather than by its functionality. The paper argues that blame could not have developed in a purely instrumental form, and that its functionality itself demands that its functionality be effaced in favour of non-instrumental reasons for blame—its functionality is self-effacing. This notion is (...) sharpened and it is shown how it offers an alternative to instrumentalist or consequentialist accounts of blame which preserves their animating insight while avoiding their weaknesses by recasting that insight in an explanatory role. This not only allows one to do better justice to the authority and autonomy of non-instrumental reasons for blame, but also reveals that autonomy to be a precondition of blame’s functionality. Unlike rival accounts, it also avoids the “alienation effect” that renders blame unstable under reflection by undercutting the authority of the moral reasons which enable it to perform its function in the first place. It instead yields a vindicatory explanation that strengthens our confidence in those moral reasons. (shrink)

The paper is structured as follows. §1 lays out the worry that the FA analysis fosters a revisionary understanding of emotional values. §2 introduces the distinction between enablers and favourers and how it is pressed into service by Toni to reply to this worry. While I agree that the reply is attractive, since casting emotions in the role of enablers chimes well with how we pre-theoretically understand the relations between emotions and values, I observe that doing so requires that we (...) tackle two connected issues. First, how do emotions function as value enablers? Second, is the resulting picture compatible with the FA analysis? The rest of the discussion is structured around these issues. §3 looks at the role of emotions within the FA analysis so as to specify the kind of enabling role they can play. On this backdrop, I explore in §4 a contrast between how belief relates to truth and how emotions relate to values, a contrast which helps uncover what we are after. A first reaction to this contrast, according to which emotions are value enablers by allowing us to access values, which differ from truth, is examined in §5. I argue that this idea cannot do justice to the key insight of the FA analysis. §6 defends an alternative idea, according to which emotions are enablers in virtue of their attitudinal shapes. (shrink)

What is the function of morality? On this question, something approaching a consensus has recently emerged. Impressed by developments in evolutionary theory, many philosophers now tell us that the function of morality is to reduce social tensions, and to thereby enable a society to efficiently promote the well-being of its members. In this paper, I subject this consensus to rigorous scrutiny, arguing that the functional hypothesis in question is not well supported. In particular, I attack the supposed evidential (...) relation between an evolutionary genealogy of morals and the functional hypothesis itself. I show that there are a great many functionally relevant discontinuities between our own culture and the culture within which morality allegedly emerged, and I argue that this seriously weakens the inference from morality’s evolutionary history to its present-day function. (shrink)

The “nature” of an artifact is often equated with its function. Clearly, an artifactual function must be an extrinsic property. This feature of functions has important implications on the semantics of artifactual kind terms: it enables us to vindicate that artifactual kind terms have an externalist semantics. Any alleged externalist theory, indeed, must show that the referents of the considered terms share a common nature (i.e., an extrinsic property), whether we know or could possibly ever know what that (...) nature is. However, the state of the art shows that function is not enough to represent such “nature”: function does not exhaustively account for important phenomena that characterize artifacts and artifactual kinds, nor does it thoroughly define what they are. Thus, extending the scope of externalism to artifactual kind terms seems doomed to fail. Pace opposite views, it could even be argued that artifacts are a sub-class of social kinds. If so, not only social but also artifactual kind terms cannot refer externalistically, since their referents constitutively depend on human intentions and norms. Either way, externalism fails to apply to those kinds of terms. (shrink)

Cushman argues that the function of rationalization is to attribute mental representations to ourselves, thereby making these representations available for future planning. I argue that such attribution is often not necessary and sometimes maladaptive. I suggest a different explanation of rationalization: making representations available to other agents, to facilitate cooperation, transmission, and the ratchet effect that underlies cumulative cultural evolution.

Background We report a randomised controlled clinical trial of neurofeedback therapy intervention for ADHD/ADD in adults. We focus on internal mechanics of neurofeedback learning, to elucidate the primary role of cortical self-regulation in neurofeedback. We report initial results; more extensive analysis will follow. Methods Trial has two phases: intervention and follow-up. The intervention consisted of neurofeedback treatment, including intake and outtake measurements, using a waiting-list control group. Treatment involved $\sim$40 hour-long sessions 2-5 times per week. Training involved either theta/beta or (...) sensorimotor-rhythm regimes, adapted by adding a novel 'inverse-training' condition to promote self-regulation. Follow-up (ongoing) will consist of self-report and executive function tests. Setting Intake and outtake measurements were conducted at University of Helsinki. Treatment was administered at partner clinic Mental Capital Care, Helsinki. Randomisation We randomly allocated half the sample then adaptively allocated the remainder to minimise baseline differences in prognostic variables. Blinding Waiting-list control design meant trial was not blinded. Participants 54 adult Finnish participants (mean age 36 years; 29 females) were recruited after screening by psychiatric review. 44 had ADHD diagnoses, 10 had ADD. Measurements Symptoms were assessed by computerised attention test (T.O.V.A.) and self-report scales, at intake and outtake. Performance during neurofeedback trials was recorded. Results Participants were recruited and completed intake measurements during summer 2012, before assignment to treatment and control, September 2012. Outtake measurements ran April-August 2013. After dropouts, 23 treatment and 21 waiting-list participants remained for analysis. Initial analysis showed that, compared to waiting-list control, neurofeedback promoted improvement of self-reported ADHD symptoms, but did not show transfer of learning to T.O.V.A. Comprehensive analysis will be reported elsewhere. Trial Registration "Computer Enabled Neuroplasticity Treatment (CENT)", ISRCTN13915109. Partly funded by Finnish science agency TEKES, project #440078. (shrink)

An examination of difficulties in three standard accounts of functions leads to the suggestion that sentences of the form "the function of x is to do y" are used to make a variety of different claims, all of which involve a means-end relationship and the idea of design, or use, or benefit. The analysis proposed enables us to see what is right and also wrong with accounts that analyze the meaning of function statements in terms of good consequences, (...) goals, and etiological explanation. It also enables us to show that function sentences can be used in providing various types of explanations, including, in certain cases, noncausal explanations of the presence of the item with the function. (shrink)

The etiological account of teleological function is beset by several difficulties, which I propose to solve by grafting onto the etiological theory a subordinated goal-contribution clause. This approach enables us to ascribe neither too many teleofunctions nor too few; to give a unitary, one-clause analysis that works just as well for teleological functions derived from Darwinian evolution, as for those derived from human intention; and finally, to save the etiological theory from falsification, by explaining how, in spite of appearances, (...) the theory can allow for evolutionary function loss. (shrink)

I argue for two claims. First I argue against the consensus view that accurate behavioral prediction based on accurate representation of cognitive states, i.e. mind reading , is the sustaining function of propositional attitude ascription. This practice cannot have been selected in evolution and cannot persist, in virtue of its predictive utility, because there are principled reasons why it is inadequate as a tool for behavioral prediction. Second I give reasons that favor an alternative account of the sustaining (...) class='Hi'>function of propositional attitude ascription. I argue that it serves a mind-shaping function. Roughly, propositional attitude ascription enables human beings to set up regulative ideals that function to mold behavior so as to make it easier to coordinate with. (shrink)

The notion of vulnerable groups has gained relevance in international legal instruments while being criticised in philosophical literature for its disabling potential and disempowering consequences. The article argues that the category of group vulnerability should not be abandoned, being an opportunity for resistance, visibility, and a place for dissent: vulnerable groups can both function as a sounding board for claims and make demands for recognition, resetting the political agenda and the topics of public debate, and allow the level of (...) collective needs to emerge from the level of individual interests, thereby guaranteeing a fairer distribution of resources. For this purpose, the article provides two definitions of group vulnerability that avoid both the risks of essentialism and of labelling outcomes. The article also analyses the political value of vulnerable groups, highlighting that it is conceivable as an enabling condition, a source of political agency and mobilisation. (shrink)

Truth is often considered to be a logico-linguistic tool for expressing indirect endorsements and infinite conjunctions. In this article, I will point out another logico-linguistic function of truth: to enable and validate what I call a blind argument, namely, an argument that involves indirectly endorsed statements. Admitting this function among the logico-linguistic functions of truth has some interesting consequences. In particular, it yields a new type of so-called conservativeness argument, which poses a new type of threat to deflationism (...) about truth. (shrink)

BackgroundThe international crisis of declining learner wellbeing exacerbated by the COVID-19 pandemic with its devastating effects on physical health and wellbeing, impels the prioritization of initiatives for specifically enabling academic and personal wellbeing among school learners to ensure autonomous functioning and flourishing in academic and daily life. Research emphasizes the role of self-directed action in fostering wellbeing. However, there is limited research evidence of how self-directed action among school learners could be advanced.AimWe explore the effectiveness of an intervention initiative (...) that exposes teachers to foregrounding Cognitive Education – the explicit and purposeful teaching of thinking skills and dispositions to learners that would advance self-regulated action - to establish the latent potential of the intervention for assisting learners to develop self-regulating abilities that progressively inspires increased self-directed action.MethodWe illuminate the qualitative outcomes of an exploratory pilot study with a heterogeneous group of willing in-service teachers from two public primary schools, one private primary school, and one pre-school in South Africa who received exposure to an 80-h intervention that comprised seven study units. The article delineates the experiences of the teachers concerning their participation in the intervention as reflected in their written reflections, as well as their perceptions about the value of the intervention probed with semi-structured one-on-one interviews after completion of the intervention.ResultsThe findings revealed that exposure to the intervention holds benefits for equipping teachers with teaching strategies to create classroom conditions that nurture the development of thinking skills and dispositions that are important for self-regulating, and ultimately self-directing academic and personal wellbeing.ConclusionCognitive Education is a form of strengths-based education that can play an indispensable role in enabling self-directed academic and personal wellbeing among school learners. (shrink)

The last decade has seen an explosion of research on the gut microbiota—the trillions of microorganisms that colonize the human gut. It is now clear that interindividual diversity in microbiota composition plays an important role in determining susceptibility to a wide variety of diseases. However, identifying the precise changes in microbiota composition that play causal roles has remained a largely unrealized goal. Here, we propose that functional classifications of microbes based on their interactions with and effects on the host—particularly the (...) host immune system—will illuminate the role of the microbiota in shaping human physiology. We outline the benefits of “functional” classification compared to phylogenetic classifications, and review current efforts at functional classification of the microbiota. Finally, we outline a theoretical framework for classifying host-microbiota interactions. Future advances enabling broader functional classifications of the microbiota promise to revolutionize our understanding of the role of gut microbes in health and disease. Functional classifications of the human microbiota reveal previously hidden patterns and will be key to cracking the microbiota composition code. This figure shows a theoretical comparison between phylogenetic classification and functional classification of a host-associated microbial community. (shrink)

Both physiological and evolutionary criteria of biological individuality are underpinned by the idea that an individual is a functionally integrated whole. However, a precise account of functional integration has not been provided so far, and current notions are not developed in the details, especially in the case of composite systems. To address this issue, this paper focuses on the organisational dimension of two representative associations of prokaryotes: biofilms and the endosymbiosis between prokaryotes. Some critical voices have been raised against the (...) thesis that biofilms are biological individuals. Nevertheless, it has not been investigated which structural and functional obstacles may prevent them from being fully integrated physiological or evolutionary units. By contrast, the endosymbiotic association of different species of prokaryotes has the potential for achieving a different type of physiological integration based on a common boundary and interlocked functions. This type of association had made it possible, under specific conditions, to evolve endosymbionts into fully integrated organelles. This paper therefore has three aims: first, to analyse the organisational conditions and the physiological mechanisms that enable integration in prokaryotic associations; second, to discuss the organisational differences between biofilms and prokaryotic endosymbiosis and the types of integration they achieve; finally, to provide a more precise account of functional integration based on these case studies. (shrink)

This paper is concerned with the problem of giving a correct analysis of function statements as they are used in biology. Examples of such statements are (1) The function of the myelin sheath is to insulate the nerve fiber and (2) The function of chlorophyll is to enable photosynthesis to take place. After criticizing analyses of such statements developed by Braithwaite, Nagel and Hempel an analysis is presented by the author. Finally the question of whether function (...) statements are explanations is discussed briefly. (shrink)

Current philosophical theorizing about technical functions is mainly focused on specifying conditions under which agents are justified in ascribing functions to technical artifacts. Yet, assessing the precise explanatory relevance of such function ascriptions is, by and large, a neglected topic in the philosophy of technical artifacts and technical functions. We assess the explanatory utility of ascriptions of technical functions in the following three explanation-seeking contexts: why was artifact x produced?, why does artifact x not have the expected capacity to (...) ϕ?, how does artifact x realize its capacity to ϕ? We argue that while function ascriptions serve a mere heuristic role in the first context, they have substantial explanatory leverage in the second and third context. In addition, we assess the relevance of function ascriptions in the context of engineering redesign. Here, function ascriptions also play a relevant role: they enable normative statements of the sort that component b functions better than component a. We unpack these claims by considering philosophical theories of technical functions, in particular the ICE theory, and engineering work on function ascription and explanation. We close the paper by relating our analysis to current debates on the explanatory power of mechanistic vis-à-vis functional explanations. (shrink)

Deflationists claim that the truth predicate was introduced into our language merely to full a certain logico-linguistic function. Oddly enough, the question what this function exactly consists in has received little attention. We argue that the best way of understanding the function of the truth predicate is as enabling us to mimic higher-order quantification in a first-order framework. Indeed, one can show that the full simple theory of types is reducible to disquotational principles of truth. Our (...) analysis has important consequences for our understanding of truth. In this paper, we can only touch on one of them: we will argue that the insubstantiality of truth does not imply a conservativity requirement on our best theories of truth. (shrink)

This book explains the relationship between intelligence and environmental complexity, and in so doing links philosophy of mind to more general issues about the relations between organisms and environments, and to the general pattern of 'externalist' explanations. The author provides a biological approach to the investigation of mind and cognition in nature. In particular he explores the idea that the function of cognition is to enable agents to deal with environmental complexity. The history of the idea in the work (...) of Dewey and Spencer is considered, as is the impact of recent evolutionary theory on our understanding of the place of mind in nature. (shrink)

Human beings are epistemically interdependent. Much of what we know and much of what we need to know we glean from others. Being a gregarious bunch, we are prone to venturing opinions whether they are warranted or not. This makes information transfer a tricky business. What we want from others is not just information, but reliable information. When we seek information, we are in the position of enquirers not examiners. We ask someone whether p because we do not ourselves already (...) know whether p. So we cannot check our informant’s bona fides by seeing whether she is speaking the truth about p. We need grounds for trust. In What’s the Point of Knowledge? Michael Hannon maintains that this is the predicament that underlies the concept of knowledge. The we here is comprehensive. Evidently, every language has a word for knowledge. This, Hannon suggests, indicates that the concept of knowledge satisfies a universal human need. A goal, if not the goal, of epistemology is to identify that need and ascertain how it is satisfied. Following Craig, Hannon argues that the point of knowledge is to enable us to identify good – that is, suitably reliable – informants. Let us call this the information transfer view. (shrink)

Applying Snyder and Feldman's 1984 consolidation‐transition model to moral judgement development has enabled further understanding of how moral judgement translates to moral functioning. In this study, 178 college students were identified as being in consolidated versus transitional phases of moral judgement development using Rest's Defining Issues Test (DIT). Participant moral functioning was inferred through an honest decision‐making index along with Attitudes Towards Human Rights Inventory (ATHRI) and Volunteer Functions Inventory (VFI) scores. Multivariate Analyses of Variance revealed that the consolidated group (...) was significantly more honest than the transitional group. No differences attributable to moral judgement phase were seen for ATHRI and VFI scores. Findings support the claim that consolidated phases improve the explanatory power of moral judgement for certain moral functional outcomes—particularly those involving ambiguity and minimal time for decision‐making. (shrink)

Placeholders enable conceptual change only if presumed to be relevant (e.g., lead to the formation of true beliefs) even though their meaning is not yet fully understood and their cognitive function not yet specified. Humans are predisposed to make such presumptions in a communicative context. Specifying the role of the presumption of relevance in conceptual change would provide a more comprehensive account of Quinian bootstrapping.

In this paper I develop a theory of 'function' and function as a deontic modal word and phenomenon. Kratzer’s account of the semantics for the deontic modals is invoked and using her approach a formal schema for the semantics of 'function'-sentences is proposed. My account of function is a modalized and extended version of Cummins’ systems-type account of function. In the biological and physical sciences, on this account, function is a complex empirical deontic modal (...) property. It is built on the property of X’s doing Y well enough to enable Z, which is implicitly deontic because of the evaluative but nonetheless empirical in its biological and physical applications. This account of function resolves many of the traditional puzzles about biological and physical function, and extends naturally to include the other types of function. With a variant treatment of the semantics, this account is argued also to apply to mathematical function, where it is shown to be interestingly related to Frege’s account of function. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Philosophy, Psychiatry, & Psychology 9.3 (2002) 237-241 [Access article in PDF] Practical, Functional, and Natural Kinds Nick Haslam Keywords: Classification, essentialism, natural kinds, practical kinds. I am grateful to the two commentators for giving my paper their serious attention, and for writing such stimulating, clarifying, and challenging responses. In a brief response I can only begin to discuss a select few issues, although both commentaries could generate a great (...) deal of profitable exchange.Zachar's commentary elaborates his practical kinds model, discusses several of the graded series of kinds proposed in my taxonomy of psychiatric categories, and disputes some aspects of my treatment of natural kinds. Zachar and I have no quarrel on his first point. I recognize his practical kinds model as a general theory of psychiatric classification rather than simply as a description of one type of category, the "practical kind." It was perhaps bad form to pilfer a term from Zachar's model and give it a more circumscribed role in my own, although by doing so I intended both to acknowledge the importance of the concept and to situate it among some of its alternatives.All the same, I stand by the account of practical kinds developed in my paper, even if it reflects a narrower sense than Zachar's. In my sense, practical kinds are pragmatically drawn distinctions imposed on continuous dimensions, whereas to Zachar all psychiatric categories are at least to some degree practical. He therefore proposes a broad "continuum" of practical kinds. The difficulty that I have with this proposal is that such a continuum implies a fundamental unity among psychiatric categories: categories are all to be understood first and foremost in pragmatic terms and differences in kind between them in internal structure are to be neglected. In my view, although the pragmatic bases of psychiatric classification are vitally important, and perhaps inadequately formulated in my paper, the neglect of internal structure and of possible breaks in the continuum of kinds are real limitations of the practical kinds model. Although Zachar is partially justified in claiming that his view is pluralistic, allowing as it does for variability in degrees of practicality, by failing to acknowledge distinctly different kinds of categories in the psychiatric domain, his view is less pluralistic than I believe it should be.One example of what I take to be this neglect of structural differences is a conflation of two sorts of practicality in Zachar's work. On the one hand, certain categories such as hypertension or obesity are defined on pragmatic grounds, a binary distinction being drawn in the absence of an internal discontinuity, because individuals identified as category members are adjudged to [End Page 237] be at significantly elevated risk. On the other hand, some categories just happen to have high practical utility. Zachar argues that schizotaxia, for example, is practical because it affords a variety of scientific and clinical inferences.It seems to me that these sorts of practicality—or perhaps these sorts of relations to practicality—are importantly different. Hypertension is defined as a category because of its practical utility—because a certain blood pressure threshold marks an inflection in actuarial risk of other illnesses—and might therefore be said to have "front-end" or constitutive practicality. Schizotaxia, which taxometric research shows to be a discrete kind (Haslam, 2003), is not defined and identified primarily on the basis of its relation to an external criterion, but on the basis of its internal structure. Its features cohere in a way that indicates a category with a determinate prevalence. It has "back-end" or consequential practicality to the degree that this category enables useful predictions. These two proposed forms of practicality are equally important: both mean that categories will be pragmatically valuable. However, they are also different, being characteristic of different kinds of categories and perhaps even negatively related. Kinds with front-end practicality, that is, may tend to have a more restricted range of practical implications, defined as they are in relation to specific external criteria. Kinds with back-end practicality, in contrast, may enable a wider array of predictions to the extent that... (shrink)

This paper deals with the "functions of intentional explanations" of actions (IEAs), i.e., explanations that refer to intentional states (beliefs, desires, etc.) of the agent. IEAs can have different formats. We consider these different formats to be instruments that enable the explainer to capture different kinds of information. We pick out two specific formats, i.e. "contrastive" and "descriptive", which will enable us to discuss the functions of IEAs. In many cases the explanation is contrastive, i.e. it makes use of one (...) or more contrasts between real intentional states and ideal intentional states (ideal from the point of view of the explainer). In many other cases IEAs have a descriptive (covering-law) format. The aim of this paper is to analyze the functions the two kinds of explanations can have. We will show that certain functions are better served by one rather than the other format. This leads to pluralism with respect to formats. We argue that both formats are necessary and that their functions are complementary. (shrink)

Drawing upon work in evolutionary game theory and experimental philosophy, I argue that one of the roles the concept of knowledge plays in our social cognitive ecology is that of enabling us to make adaptively important distinctions between different kinds of blameworthy and blameless behaviors. In particular, I argue that knowledge enables us to distinguish which agents are most worthy of blame for inflicting harms, violating social norms, or cheating in situations of social exchange.

In this paper we intend to propose a definition of function in biology. First we delimitated the problem and pointed out that a definition must not be related to hypotheses such as the causal connexion between form and function, phylogenetics or evolution, but that only the existence of functions is to be considered. The elements to be expressed in the definition are: the relation of function to form, the dynamic character, the integration into the activity of the (...) total organism, the possibility of latent functions and the fact that in the case of mechanical functions the function is not itself action, but directly related to it. So we proposed the following definition: A biological function is a property of a definite part of the total organism, marked by a certain form or structure, which property is actual or potential activity itself or directly related to activity, and by which the development and the maintenance of the organism as a whole is enabled to proceed in a harmonious way.We finished with some theoretical remarks in which the logical dependence of the function on the form is brought forward. Therefore form and function are not an example of the principle of complementarity, as is stated byMeyer-Abich. Attention is also given to a former paper byBarge on the form-function problem. This paper served as the starting point for the present discussion.Dans cette étude nous avons l'intention de proposer une définition de fonction en biologie. D'abord nous avons délimité le problème et faisons remarquer qu'une définition ne doit pas être mise en rapport avec des hypothèses comme la relation causale entre forme et fonction, phylogénèses ou évolution, mais que seule l'existence de fonctions doît être considerée. Les éléments qui doivent être exprimés sont: la relation de fonction à la forme, le caractère dynamique, l'intégration dans l'activité de l'organisme total, la possibilité de fonctions latentes et le fait qu'au cas de fonctions méchaniques le fonction même n'est pas action, mais y est immédiatement relative. Ainsi nous proposons la définition suivante: Une fonction biologique est une propriété d'une partie définie de l'organisme total, marquée par une certaine forme ou structure, laquelle propriété est activité actuelle ou potentielle elle-même, ou bien directement relative à l'activité et par laquelle le développement et le maintien de l'organisme total est mis à même d'avancer harmonieusement.Nous avons fini en faisant quelques remarques théoriques, où nous avons exposé que la fonction dépend logiquement de la forme. C'est pourquoi forme et fonction ne sont pas un exemple du principe de complémentement comme cela a été prétendu parMeyer-Abich. Nous avons également fait attention à une étude antérieure deBarge touchant le problème forme-fonction. Cette étude a servi comme point de départ à la discussion présente.Wir haben in dieser Abhandlung versucht eine Definition der “biologischen Funktion” zu geben. Zunächst beschränkten wir uns darauf, darzulegen, dass man bei einer Definition nicht auf Hypothesen hinweisen soll, wie z.B. auf den Kausalzusammenhang zwischen Form und Funktion, Phylogenese oder Evolution. Es soll lediglich des Bestehen von Funktionen berücksichtigt werden.Folgende Elemente müssen in der Definition zum Ausdruck kommen: die Beziehung der Funktion zur Form, der dynamische Charakter, die Integrierung in die Aktivität des Organismus als Ganzes, die Möglichkeit latenter Funktionen und die Tatsache, dass die Funktion im Falle einer mechanischen Funktion selbst nicht Aktivität ist, jedoch in direkter Beziehung zu ihr steht.Wir haben daher die folgende Definition vorgeschlagen: Eine biologische Funktion ist die Eigenschaft eines bestimmten Teiles des Organismus als Ganzes der eine bestimmte Form oder Struktur besitzt: diese Eigenschaft ist ihrerseits wirkliche oder mögliche Aktivität oder aber steht in einem direkten Verhältnis zu ihr; sie ermöglicht die harmonische Entwicklung und Erhaltung des Organismus als Ganzes.Zum Abschluss machten wir einige theoretische Bemerkungen in denen wir die logische Abhängigkeit der Funktion von der Form darlegten. Form und Funktion sind demzufolge kein Musterbeispiel für das Komplementaritäts-prinzip so wie es vonMeyer-Abich angeführt wird. Wir haben uns auch mit einer früheren Abhandlung über das Form-Funktion-Problem vonBarge befasst. Sie diente uns als Ausgangspunkt für die gegenwärtige Erörterung. (shrink)

This chapter examines a question at the intersection of the mind-body problem and the analysis of mental representation: the question of the direction of constraint between psychological fact and theory and neurophysiological or physical fact and theory. Does physiology constrain psychology? Are physiological facts more basic than psychological facts? Or do psychological theories, including representational analyses, guide and constrain physiology? Despite the antireductionist bent of functionalist positions, it has generally been assumed that physics or physiology are more basic than, and (...) hence contraining on, psychological fact and theory. Section 1 sketches the intuitions that would lead one to adopt such a view. The chapter then examines whether one-sided constraint has been and should be found in practice. It argues that philosophical analysis of psychological science shows that rigorous functional analyses can be carried out in advance of physiological knowledge. Indeed, in the investigation of sensory perception, ascription of psychological function leads the way in the individuation and investigation of neurophysiology. We shall look at several cases in visual perception (binocular single vision, stereopsis, and color vision), in which psychological results have provided a basis for physiological research. It is tempting to think that the psychological functions that enable physiological investigation would be Wrightian teleofunctions. It is, thus, natural to suppose that psychologists and neurophysiologists have proceeded with a conception of the purpose of a given neural structure, and have viewed neural anatomy and neural activity as the substrate for or instantiation of various properly psychological functions. For example, neuroscientists surely understand that the eye and visual system are for seeing, rather than for detecting an electric discharge in the vicinity of the retina (which sighted humans can do, via the subjective light produced by such discharges), and they guide their investigations of the eye, visual cortex, and intervening pathways accordingly. As a result, they will view rods and cones in the eye as photoreceptors, even though these structures will produce "output" (will respond with hyperpolarization) to other forms of energy. At the same time, there may be cases in which the functions that have guided research are in fact precisely determined input-output functions, whose teleofunctional status is absent or misdescribed. I will argue that in the case of trichromatic color matches, the psychological function involved is an input-output function, and that this result has implications for the description of color vision as a psychological capacity. (shrink)

The time is near where ‘therapeutic’ bodily assistive devices, developed to mimic species-typical body structures in order to enable normative body functioning, will allow the wearer to outperform the species-typical body in various functions. Although such devices are developed for people that are seen to exhibit sub species-typical abilities, many ‘therapeutic enhancements’ might also be desired and used by people that exhibit species-typical body abilities. This paper presents the views of members of the World Federation of the Deaf on potential (...) beyond species-typical abilities enabling therapeutic assistive devices (i.e. related to hearing). Survey respondents showed support for the development and uptake of beyond normal hearing enabling devices. The views of survey respondents as clients affect hearing-enabling professions (such as audiologist and speech pathologists). The paper analyzes what guidance code of ethics of hearing enabling professions give in regards to beyond normal hearing enabling devices. This paper suggests that people labeled impaired and the professions that serve them should more involved in the enhancement discourse. (shrink)

I propose that a feminist analysis of contemporary conversations on normalfunctioning and functional-diversity approaches to understanding disability can locate in some people’s resistances to disability an attitude compatible with respect for functional diversity. The history of feminist work in collaboration with transgender work offers an evocative model for an approach to disability that enables solidarity with those seeking functional alteration. This approach provides one way to understand how a critical analysis is compatible with respecting bodily functional desires, such that one (...) may seek physical change while working for social change alongside those successfully functioning otherwise. (shrink)

In this paper, I will present a way of understanding the mystical experience based on the role of intention in determining consciousness. This approach may enable us to understand a variety of mystical techniques and teachings without becoming entangled in obscure doctrines or religious-sounding terminology.

The aim of this paper is to provide a theoretical framework to understand how multicellular systems realize functionally integrated physiological entities by organizing their intercellular space. From a perspective centered on physiology and integration, biological systems are often characterized as organized in such a way that they realize metabolic self-production and self-maintenance. The existence and activity of their components rely on the network they realize and on the continuous management of the exchange of matter and energy with their environment. One (...) of the virtues of the organismic approach focused on organization is that it can provide an understanding of how biological systems are functionally integrated into coherent wholes. Organismic frameworks have been primarily developed by focusing on unicellular life. Multicellularity, however, presents additional challenges to our understanding of biological systems, related to how cells are capable to live together in higher-order entities, in such a way that some of their features and behaviors are constrained and controlled by the system they realize. Whereas most accounts of multicellularity focus on cell differentiation and increase in size as the main elements to understand biological systems at this level of organization, we argue that these factors are insufficient to provide an understanding of how cells are physically and functionally integrated in a coherent system. In this paper, we provide a new theoretical framework to understand multicellularity, capable to overcome these issues. Our thesis is that one of the fundamental theoretical principles to understand multicellularity, which is missing or underdeveloped in current accounts, is the functional organization of the intercellular space. In our view, the capability to be organized in space plays a central role in this context, as it enables (and allows to exploit all the implications of) cell differentiation and increase in size, and even specialized functions such as immunity. We argue that the extracellular matrix plays a crucial active role in this respect, as an evolutionary ancient and specific (non-cellular) control subsystem that contributes as a key actor to the functional specification of the multicellular space and to modulate cell fate and behavior. We also analyze how multicellular systems exert control upon internal movement and communication. Finally, we show how the organization of space is involved in some of the failures of multicellular organization, such as aging and cancer. (shrink)

Consciousness is a mongrel concept: there are a number of very different "consciousnesses." Phenomenal consciousness is experience; the phenomenally conscious aspect of a state is what it is like to be in that state. The mark of access-consciousness, by contrast, is availability for use in reasoning and rationally guiding speech and action. These concepts are often partly or totally conflated, with bad results. This target article uses as an example a form of reasoning about a function of "consciousness" based (...) on the phenomenon of blindsight. Some information about stimuli in the blind field is represented in the brains of blindsight patients, as shown by their correct "guesses," but they cannot harness this information in the service of action, and this is said to show that a function of phenomenal consciousness is somehow to enable information represented in the brain to guide action. But stimuli in the blind field are BOTH access-unconscious and phenomenally unconscious. The fallacy is: an obvious function of the machinery of access-consciousness is illicitly transferred to phenomenal consciousness. (shrink)

Logics for ‘generally’ are intended to express some vague notions, such as ‘generally’, ‘several’, ‘many’, ‘most’, etc., by means of the new generalized quantifier ∇ and to reason about assertions with ‘generally’ . We introduce the idea of functional interpretation for ‘generally’ and show that representative functions enable elimination of ∇ and reduce consequence to classical theories. Thus, one can use proof procedures and theorem provers for classical first-order logic to reason about assertions involving ‘generally’.

We introduce a new and time-efficient memory-encoding paradigm for functional magnetic resonance imaging. This paradigm is optimized for mapping multiple contrasts using a mixed design, using auditory and visual stimuli. We demonstrate that the paradigm evokes robust neuronal activity in typical sensory and memory networks. We were able to detect auditory and visual sensory-specific encoding activities in auditory and visual cortices. Also, we detected stimulus-selective activation in environmental-, voice-, scene-, and face-selective brain regions. A subsequent recognition task allowed the detection (...) of sensory-specific encoding success activity in both auditory and visual cortices, as well as sensory-unspecific positive ESA in the hippocampus. Further, sensory-unspecific negative ESA was observed in the precuneus. Among others, the parallel mixed design enabled sustained and transient activity comparison in contrast to rest blocks. Sustained and transient activations showed great overlap in most sensory brain regions, whereas several regions, typically associated with the default-mode network, showed transient rather than sustained deactivation. We also show that the use of a parallel mixed model had relatively little influence on positive or negative ESA. Together, these results demonstrate a feasible, versatile, and brief memory-encoding task, which includes multiple sensory stimuli to guarantee a comprehensive measurement. This task is especially suitable for large-scale clinical or population studies, which aim to test task-evoked sensory-specific and sensory-unspecific memory-encoding performance as well as broad sensory activity across the life span within a very limited time frame. (shrink)

This article discusses the ideological character of the notion of functional differentiation. According to Luhmann, the development of worldwide social differentiation leads to different regional developments and generates, through the inclusion/exclusion code, a division of the world between places where the functional differentiation operates appropriately and inappropriately. This paper argues, however, that functional differentiation is only readable as an ensemble of relations of power and ideological discourses. This subject is developed in light of theoretical approaches from the Marxist tradition and (...) from postcolonial studies. Regarding the first, the functional differentiation is reread as an abstract and generic equality, which permits the material reproduction of regional inequality. This idea provides a background for discussing the ideological features of the functional differentiation which serves the dominant position of Western countries in the international arena since it enables the maintenance of a ruling ideology, according to which the world is differentiated between the ‘civilized’ West and the ‘uncivilized’ non-West. (shrink)

Objective: The present work aims to conduct the first naturalistic empirical investigation of the process and outcome assessment of functional psychotherapy treatment. The FP model of psychotherapy is rooted in psychoanalysis and integrates the verbal communication approach founded on transference and countertransference dynamics with the analysis of bodily processes.Method: The study sample included ten patients recruited on a voluntary basis and treated by clinicians in their private practices. Each patient received FP with an average duration of 40 h. Therapies had (...) weekly sessions, were audio-recorded with the patient’s written consent, and lasted for an average of 10 months. Outcome and process tools included the Minnesota Multiphasic Personality Inventory-2 and the Luborsky’s the Core Conflictual Relationship Theme, used to assess therapeutic benefit, and the Metacognition Assessment Scale and the Italian Discourse Attributes Analysis Program system, used to evaluate therapeutic benefit and process. The MMPI-2 was used also in the follow-up assessment.Results: Results show that FP had a positive therapeutic outcome on the patients assessed in this study, and that the therapeutic benefits were maintained over time. Some specific features of the FP approach were found to contribute more than others to the observed therapeutic benefits.Conclusion: The current investigation constitutes a first step toward assessment of the therapeutic effectiveness of FP. Future developments should apply the methodology to a larger sample, possibly introducing different methodologies to enable detection of specific bodily oriented processes and techniques. (shrink)

This paper presents a multimodal analysis of the design of an online fashion shop. Departing from systemic-functional genre theory, it analyses the functionality of the site, bringing out how it designs what sellers do to and for consumers and what the site does and does not enable consumers to do. Drawing on Joos’ analysis of formality in language and Hall’s proxemics, the paper then analyses how the site conceals the power of its functional design by simulating informality and solidarity in (...) a way that ultimately remains one-way and cannot be reciprocated. It finally argues that designs of consumer behaviour similar to that of the analysed site increasingly stand as a model for the digitization of other domains of practice, including education and research, so extending what Fairclough called the ‘marketization of discourse’ into these other domains. (shrink)

The interactivist model has explored a number of consequences of process metaphysics. These include reversals of some fundamental metaphysical assumptions dominant since the ancient Greeks, and multiple further consequences throughout the metaphysics of the world, minds, and persons. This article surveys some of these consequences, ranging from issues regarding entities and supervenience to the emergence of normative phenomena such as representation, rationality, persons, and ethics.

The inositol phosphate metabolism network has been found to be much more complex than previously thought, as more and more inositol phosphates and their metabolizing enzymes have been discovered. Some of the inositol phosphates have been shown to have biological activities, but little is known about their signal transduction mechanisms except for that of inositol 1,4,5‐trisphosphate. The recent discovery, however, of a number of binding proteins for inositol high polyphosphate [inositol 1,3,4,5‐tetrakisphosphate (IP4), inositol 1,3,4,5,6‐pentakisphosphate, or inositol hexakisphosphate] enables us to (...) speculate on the physiological function of these compounds. In this article we focus on two major issues: (1) the roles of inositol high polyphosphates in vesicular trafficking, especially exocytosis, and (2) pleckstrin homology domaincontaining IP4 binding proteins involved in the Ras signaling pathway. (shrink)