The potential use of stem cells in the treatment of a variety of human diseases has been a major driving force for embryonic stem cell research. Another productive area of research has been the use of human stem cells to reconstitute human organ systems in animals in an attempt to create new animal models for human diseases. However, the possibility of transplanting human embryonic brain cells or precursor brain cells into an animal fetus presents numerous ethical challenges. This paper examines, (...) from a Jewish perspective on human dignity, several bioethical concerns related to the reconstitution of animal brains with human neurons. (shrink)

The bioethical principle of autonomy is problematic regarding the future of the embryo who lacks the ability to self-advocate but will develop this defining human capacity in time. Recent experiments explore the use of clustered regularly interspaced short palindromic repeats /Cas9 for germline engineering in the embryo, which alters future generations. The embryo’s inability to express an autonomous decision is an obvious bioethical challenge of germline engineering. The philosopher Joel Feinberg acknowledged that autonomy is developing in children. He advocated that (...) to reserve this future autonomy, parents should be guided to make ethical decisions that provide children with open futures. Here, Feinberg’s 1980 open future theory is extended to the human embryo in the context of CRISPR germline engineering. Although the embryo does not possess the autonomous decision-making capacity at the time of germline engineering, the parental decision to permanently change the unique genetic fabric of the embryo and subsequent generations disregards future autonomy. Therefore, germline engineering in many instances is objectionable considering Feinberg’s open future theory. (shrink)

Loneliness in medicine is a serious problem not just for patients, for whom illness is intrinsically isolating, but also for physicians in the contemporary condition of medicine. We explore this problem by investigating the ideal physician-patient relationship, whose analogy with friendship has held enduring normative appeal. Drawing from Talbot Brewer and Nir Ben-Moshe, we argue that this appeal lies in a dynamic form of companionship incompatible with static models of friendship-like physician-patient relationships: a mutual refinement of embodied virtue that draws (...) both persons together. The ideal physician-patient relationship has a dialectical character that fosters each member's improvement of phenomenologically recognizing and embodying moral virtues. A key component of this dynamic is a commitment to the common goal of the patient's health, realized through joint interactivities and conversations over time. The physician's presence to the patient's suffering—understood best as an alienating phenomenological condition for the patient—orients and discloses possibilities for virtuous caregiving by structuring the meanings of the goals, conversations, and joint narrative constitutive of their relationship. Presence to suffering, paradoxically, is perhaps an important prerequisite for this dynamic partnership. These activities dialectically build an interpretive horizon of understanding through which moral goods and character refinement—in and for the other—may become revealed for both persons in their shared being-in-the-world. This analysis of suffering, mood, and revealing of (possible) moral goods has implications for addressing the modern problem of loneliness for patients and physicians, who are increasingly inhibited from building flourishing relationships with each other. (shrink)

The essays in this volume are concerned with our everyday and developed scientific systems of explanation of human behavior in terms of beliefs, attitudes,...

Ever since Copernicus, scientists have continually adjusted their view of human nature, moving it further and further from its ancient position at the center of Creation. But in recent years, a startling new concept has evolved that places it more firmly than ever in a special position. Known as the Anthropic Cosmological Principle, this collection of ideas holds that the existence of intelligent observers determines the fundamental structure of the Universe. In its most radical version, the Anthropic Principle asserts that (...) "intelligent information-processing must come into existence in the Universe, and once it comes into existence, it will never die out." This wide-ranging and detailed book explores the many ramifications of the Anthropic Cosmological Principle, covering the whole spectrum of human inquiry from Aristotle to Z bosons. Bringing a unique combination of skills and knowledge to the subject, John D. Barrow and Frank J. Tipler--two of the world's leading cosmologists--cover the definition and nature of life, the search for extraterrestrial intelligence, and the interpretation of the quantum theory in relation to the existence of observers. The book will be of vital interest to philosophers, theologians, mathematicians, scientists, and historians, as well as to anyone concerned with the connection between the vastness of the universe of stars and galaxies and the existence of life within it on a small planet out in the suburbs of the Milky Way. (shrink)

In books such as The World Within the World and The Anthropic Cosmological Principle, astronomer John Barrow has emerged as a leading writer on our efforts to understand the universe. Timothy Ferris, writing in The Times Literary Supplement of London, described him as "a temperate and accomplished humanist, scientist, and philosopher of science--a man out to make a contribution, not a show." Now Barrow offers the general reader another fascinating look at modern physics, as he explores the quest for (...) a single, unifying theory that will unlock nature's secrets. Theories of Everything is more than a history of science, more than a popular report on recent research and discoveries. Barrow provides a reflective, intelligent commentary on what a true Theory of Everything would be--its ingredients, its limitations, and what it could tell us about the universe. Never before, he writes, have physicists been so confident and so eager in the hunt for this "cosmic Rosetta Stone," as he calls it: "a single all-embracing picture of all the laws of nature from which the inevitability of all things seen must follow with unimpeachable logic." He lays out eight essential ingredients for a Theory of Everything and then explores each in turn, tracing how our knowledge has developed and how scientific discovery relates to our changing philosophy and religious thought in each area. Some of these ingredients are obvious--the laws of nature must be explained, for example, as well as its organizing principles--but others may be surprising, such as broken symmetries and selection biases. A Theory of Everything must account for the fact that the universe is "messy and complicated," he tells us, and for the limitations imposed by the questions we ask and the information we can obtain. The key lies in the remarkable capacity of mathematics to express the fundamental workings of the physical world--a language that the human mind is uniquely equipped to understand and manipulate. Barrow examines what mathematics actually is and describes how it makes the universe intelligible and provides a path to the underlying coherence in nature--which has led, in fact, to arguments that the universe itself is a vast computer. Yet even the most complete theory, even the most comprehensive mathematical explanation, cannot account for the uncomputable varieties of human experience and thought. "No non-poetic account of reality," he writes, "can be complete." In a field where the authorities converse in equations and mathematical notations, John Barrow speaks with the voice of thoughtful and knowledgeable humanist. Written with eloquence and expertise, Theories of Everything establishes a new perspective on humanity's efforts to explain the universe. (shrink)

An infinite lottery machine is used as a foil for testing the reach of inductive inference, since inferences concerning it require novel extensions of probability. Its use is defensible if there is some sense in which the lottery is physically possible, even if exotic physics is needed. I argue that exotic physics is needed and describe several proposals that fail and at least one that succeeds well enough.

The inaugural title in the new, Open Access series BSPS Open, The Material Theory of Induction will initiate a new tradition in the analysis of inductive inference. The fundamental burden of a theory of inductive inference is to determine which are the good inductive inferences or relations of inductive support and why it is that they are so. The traditional approach is modeled on that taken in accounts of deductive inference. It seeks universally applicable schemas or rules or a single (...) formal device, such as the probability calculus. After millennia of halting efforts, none of these approaches has been unequivocally successful and debates between approaches persist. The Material Theory of Induction identifies the source of these enduring problems in the assumption taken at the outset: that inductive inference can be accommodated by a single formal account with universal applicability. Instead, it argues that that there is no single, universally applicable formal account. Rather, each domain has an inductive logic native to it. Which that is, and its extent, is determined by the facts prevailing in that domain. Paying close attention to how inductive inference is conducted in science and copiously illustrated with real-world examples, The Material Theory of Induction will initiate a new tradition in the analysis of inductive inference. (shrink)

Contrary to formal theories of induction, I argue that there are no universal inductive inference schemas. The inductive inferences of science are grounded in matters of fact that hold only in particular domains, so that all inductive inference is local. Some are so localized as to defy familiar characterization. Since inductive inference schemas are underwritten by facts, we can assess and control the inductive risk taken in an induction by investigating the warrant for its underwriting facts. In learning more facts, (...) we extend our inductive reach by supplying more localized inductive inference schemes. Since a material theory no longer separates the factual and schematic parts of an induction, it proves not to be vulnerable to Hume's problem of the justification of induction. (shrink)

A textbook for undergraduates. Some 70 selections (more than half are new to this edition) follow an introductory essay. Current controversies (surrogacy, genetic engineering, proxy consent) are thoroughly covered. Annotation copyrighted by Book News, Inc., Portland, OR.

There can be no mistaking the importance of Caputo's work." —Edith Wyschogrod "No one interested in Derrida, in Caputo, or in the larger question of postmodernism and religion can afford to ignore this pathbreaking study.

John Barrow is increasingly recognized as one of our most elegant and accomplished science writers, a brilliant commentator on cosmology, mathematics, and modern physics. Barrow now tackles the heady topic of impossibility, in perhaps his strongest book yet. Writing with grace and insight, Barrow argues convincingly that there are limits to human discovery, that there are things that are ultimately unknowable, undoable, or unreachable. He first examines the limits on scientific inquiry imposed by the deficiencies of the human mind: (...) our brain evolved to meet the demands of our immediate environment, Barrow notes, and much that lies outside this small circle may also lie outside our understanding. Barrow investigates practical impossibilities, such as those imposed by complexity, uncomputability, or the finiteness of time, space, and resources. Is the universe finite or infinite? Can information be transmitted faster than the speed of light? The book also examines the deeper theoretical restrictions on our ability to know, including Godel's theorem--which proved that there were things that could not be proved--and Arrow's Impossibility theorem about democratic voting systems. Finally, having explored the limits imposed on us from without, Barrow considers whether there are limits we should impose upon ourselves. For instance, if the secrets of the atom are to be found only by recreating extreme environments at great financial cost, just how much should we devote to that quest? Weaving together this intriguing tapestry, he illuminates some of the most profound questions of science, from the possibility of time travel to the very structure of the universe. (shrink)

Canadian Journal of Philosophy, 26, pp. 333-66. 1996.

"Against Ethics is beautifully written, clever, learned, thought-provoking, and even inspiring." —Theological Studies "Writing in the form of his ideas, Caputo offers the reader a truly exquisite reading experience.... his iconic style mirrors a truly refreshing honesty that draws the reader in to play." —Quarterly Journal of Speech "Against Ethics is, in my judgment, one of the most important works on philosophical ethics that has been written in recent years.... Caputo speaks with a passion and a concern that are rare (...) in academic philosophy. His profound sense of humor deepens the passion of the viewpoints he develops." —Mark C. Taylor "Obligation happens!" declares Caputo in this brilliant and witty postmodern critique of ethics, framed as a contemporary restaging of Kierkegaard’s Fear and Trembling. (shrink)

I deny that the world is fundamentally causal, deriving the skepticism on non-Humean grounds from our enduring failures to find a contingent, universal principle of causality that holds true of our science. I explain the prevalence and fertility of causal notions in science by arguing that a causal character for many sciences can be recovered, when they are restricted to appropriately hospitable domains. There they conform to a loose collection of causal notions that form a folk science of causation. This (...) recovery of causation exploits the same generative power of reduction relations that allows us to recover gravity as a force from Einstein's general relativity and heat as a conserved fluid, the caloric, from modern thermal physics, when each theory is restricted to appropriate domains. Causes are real in science to the same degree as caloric and gravitational forces. (shrink)

Context Conflicts over treatment decisions have been linked to physicians' emotional states. Objective To measure the prevalence of emotional exhaustion and conflicts over treatment decisions among US obstetrician/gynaecologists (ob/gyns), and to examine the relationship between the two and the physician characteristics that predict each. Methods Mailed survey of a stratified random sample of 1800 US ob/gyn physicians. Criterion variables were levels of emotional exhaustion and frequency of conflict with colleagues and patients. Predictors included physicians' religious characteristics and self-perceived empathy. Results (...) Response rate among eligible physicians was 66% (1154/1760). 36% of ob/gyns reported high levels of emotional exhaustion, and majorities reported conflict with colleagues (59%) and patients (61%). Those reporting conflict were much more likely to report emotional exhaustion (58% vs 29% who never conflict, OR, 95% CI 2.8, 1.6 to 4.8 for conflict with colleagues; 55% versus 26%, OR, 95% CI 2.2, 1.4 to 3.5 for conflict with patients). Physicians with lower self-perceived empathy were more likely to report physician-patient conflicts (65% vs 58% with higher empathy, OR, 95% CI 1.4, 1.0 to 1.9), as were female ob/gyns (66% vs 57% of males, OR, 95% CI 1.5, 1.1 to 2.0). Foreign-born physicians were less likely to report such conflicts (47% vs 64% of US born, OR, 95% CI 0.5, 0.4 to 0.8). Physicians' religious characteristics were not significantly associated with reporting conflict. Conclusions Conflicts over treatment decisions are associated with physicians' empathy, gender, immigration history and level of emotional exhaustion. With respect to the latter, conflict in the clinical encounter may represent an overlooked source or sign of burnout among ob/gyns. (shrink)

Applying an ever more radical hermeneutics, John D. Caputo breaks down the name of God in this irrepressible book. Instead of looking at God as merely a name, Caputo views it as an event, or what the name conjures or promises in the future. For Caputo, the event exposes God as weak, unstable, and barely functional. While this view of God flies in the face of most religions and philosophies, it also puts up a serious challenge to fundamental tenets (...) of theology and ontology. Along the way, Caputo’s readings of the New Testament, especially of Paul’s view of the Kingdom of God, help to support the "weak force" theory. This penetrating work cuts to the core of issues and questions—What is the nature of God? What is the nature of being? What is the relationship between God and being? What is the meaning of forgiveness, faith, piety, or transcendence?—that define the terrain of contemporary philosophy of religion. (shrink)

In a formal theory of induction, inductive inferences are licensed by universal schemas. In a material theory of induction, inductive inferences are licensed by facts. With this change in the conception of the nature of induction, I argue that the celebrated “problem of induction” can no longer be set up and is thereby dissolved. Attempts to recreate the problem in the material theory of induction fail. They require relations of inductive support to conform to an unsustainable, hierarchical empiricism.

iinstein oered the prin™iple of gener—l ™ov—ri—n™e —s the fund—ment—l physi™—l prin™iple of his gener—l theory of rel—tivityD —nd —s responsi˜le for extending the prin™iple of rel—tivity to —™™eler—ted motionF „his view w—s disputed —lmost immedi—tely with the ™ounterE™l—im th—t the prin™iple w—s no rel—tivity prin™iple —nd w—s physi™—lly v—™uousF „he dis—greeE ment persists tod—yF „his —rti™le reviews the development of iinstein9s thought on gener—l ™ov—ri—n™eD its rel—tion to the found—tions of gener—l rel—tivity —nd the evolution of the ™ontinuing de˜—te (...) over his viewpointF.. (shrink)

I give an informal outline of the hole argument which shows that spacetime substantivalism leads to an undesirable indeterminism in a broad class of spacetime theories. This form of the argument depends on the selection of differentiable manifolds within a spacetime theory as representing spacetime. I consider the conditions under which the argument can be extended to address versions of spacetime substantivalism which select these differentiable manifolds plus some further structure to represent spacetime. Finally, I respond to the criticisms of (...) Tim Maudlin and Jeremy Butterfield. (shrink)

Thought experiments are ordinary argumentation disguised in a vivid pictorial or narrative form. This account of their nature will allow me to show that empiricism has nothing to fear from thought experiments. They perform no epistemic magic. In so far as they tell us about the world, thought experiments draw upon what we already know of it, either explicitly or tacitly; they then transform that knowledge by disguised argumentation. They can do nothing more epistemically than can argumentation. I defend my (...) account of thought experiments in Section 3 by urging that the epistemic reach of thought experiments turns out to coincide with that of argumentation and that this coincidence is best explained by the simple view that thought experiments just are arguments. Thought experiments can err—-a fact to be displayed by the thought experiment - anti thought experiment pairs of Section 2. Nonetheless thought experiments can be used reliably and, I urge in Section 4., this is only possible if they are governed by some very generalized logic. I will suggest on evolutionary considerations that their logics are most likely the familiar logics of induction and deduction, recovering the view that thought experiment is argumentation. Finally in Section 5 I defend this argument based epistemology of thought experiments against competing accounts. I suggest that these other accounts can offer a viable epistemology only insofar as they already incorporate the notion that thought experimentation is governed by a logic, possibly of very generalized form. (shrink)

Preface: This volume originated in a conference on "The Place of Thought Experiments in Science and Philosophy" which was organized by us and held at the Center for Philosophy of Science at the University of Pittsburgh, April 18-20, 1986. The idea behind this conference was to encourage philosophers and scientists to talk to each other about the role of thought experiments in their various disciplines. These papers were either written for the conference, or were written after it by commentators and (...) other participants.... We hope that this volume will be of use to other philosophers and scientists who are interested in thought experiments, as well as inspire more work in this area.... (shrink)

Will we ever discover a single scientific theory that explains everything that has ever happened and everything that will happen - a key that unlocks the ...

It is proposed that we use the term “approximation” for inexact description of a target system and “idealization” for another system whose properties also provide an inexact description of the target system. Since systems generated by a limiting process can often have quite unexpected, even inconsistent properties, familiar limit systems used in statistical physics can fail to provide idealizations, but are merely approximations. A dominance argument suggests that the limiting idealizations of statistical physics should be demoted to approximations.

Thought experiments in science are merely picturesque argumentation. I support this view in various ways, including the claim that it follows from the fact that thought experiments can err but can still be used reliably. The view is defended against alternatives proposed by my cosymposiasts.

Principlism : the Borg of bioethics -- A common morality for hedgehogs : Bernard Gert -- Getting down to cases : the revival of casuistry in bioethics -- Nice story but so what : narrative and justification in ethics -- Dewey and Rorty's pragmatism and bioethics -- Freestanding pragmatism in bioethics and law -- A method in search of a purpose : the internal morality of medicine -- Method to rule them all? Reflective equilibrium in bioethics -- Concluding reflections : (...) method in bioethics : the very idea. (shrink)

According to the underdetermination thesis, all evidence necessarily underdetermines any scientific theory. Thus it is often argued that our agreement on the content of mature scientific theories must be due to social and other factors. Drawing on a long standing tradition of criticism, I shall argue that the underdetermination thesis is little more than speculation based on an impoverished account of induction. A more careful look at accounts of induction does not support an assured underdetermination or the holism usually associated (...) with it. I also urge that the display of observationally equivalent theories is a self-defeating strategy for supporting the underdetermination thesis. The very fact that observational equivalence can be demonstrated by arguments brief enough to be included in a journal article means that we cannot preclude the possibility that the theories are merely variant formulations of the same theory. (shrink)

In this commentary, I critically discuss the respective views of Gert and Beauchamp–Childress on the nature of so-called common morality and its promise for enriching ethical reflection within the field of bioethics. Although I endorse Beauchamp and Childress’ shift from an emphasis on ethical theory as the source of moral norms to an emphasis on common morality, I question whether rouging up common morality to make it look like some sort of ultimate and universal foundation for morality, untouched by the (...) dialectics of time and reflective equilibrium, was an equally good move. As for Gert’s magisterial conception of common morality, I conclude that certain elements of his system are controversial at best and woefully inadequate at worst. He has a tendency to find in common morality what he himself put there, and his highly restricted conception of duties of assistance strikes this reader as ad hoc, inadequately defended, and unworthy of a project whose goal is to lessen the amount of misery in the world. (shrink)

John D. Caputo explores the very roots of religious thinking in this thought-provoking book. Compelling questions come up along the way: 'What do I love when I love my God?' and 'What can Star Wars tell us about the contemporary use of religion?' Why is religion for many a source of moral guidance in a postmodern, nihilistic age? Is it possible to have 'religion without religion'? Drawing on contemporary images of religion, such as Robert Duvall's film _The Apostle_, Caputo (...) also provides some fascinating and imaginative insights into religious fundamentalism. (shrink)

Thought experiments in science are merely picturesque argumentation. I support this view in various ways, including the claim that it follows from the fact that thought experiments can err but can still be used reliably. The view is defended against alternatives proposed by my cosymposiasts.

Bayesian probabilistic explication of inductive inference conflates neutrality of supporting evidence for some hypothesis H (“not supporting H”) with disfavoring evidence (“supporting not-H”). This expressive inadequacy leads to spurious results that are artifacts of a poor choice of inductive logic. I illustrate how such artifacts have arisen in simple inductive inferences in cosmology. In the inductive disjunctive fallacy, neutral support for many possibilities is spuriously converted into strong support for their disjunction. The Bayesian “doomsday argument” is shown to rely entirely (...) on a similar artifact, for the result disappears in a reanalysis that employs fragments of inductive logic able to represent evidential neutrality. Finally, the mere supposition of a multiverse is not yet enough to warrant the introduction of probabilities without some factual analog of a randomizer over the multiverses. (shrink)

The Insistence of God presents the provocative idea that God does not exist, God insists, while God’s existence is a human responsibility, which may or may not happen. For John D. Caputo, God’s existence is haunted by "perhaps," which does not signify indecisiveness but an openness to risk, to the unforeseeable. Perhaps constitutes a theology of what is to come and what we cannot see coming. Responding to current critics of continental philosophy, Caputo explores the materiality of perhaps and (...) the promise of the world. He shows how perhaps can become a new theology of the gaps God opens. (shrink)

While there is general agreement on the need to teach ethics in the MBA classroom, there are great difficulties in completely integrating such material within the confines of an actual MBA program. This paper attempts to address these difficulties by focusing on the teaching of such issues in one particular class — MBA macroeconomics.Ethical dilemmas often arise due to failures of the market place or due to inappropriate assumptions regarding the market model. Thus, specific suggestions are offered in regard to (...) the integration of ethical issues into the traditional macroeconomic curriculum. Suggestions are even offered as how to scale back the basic macro material so that the additional material may be accommodated. (shrink)

My purpose in this chapter is to survey some of the principal approaches to inductive inference in the philosophy of science literature. My first concern will be the general principles that underlie the many accounts of induction in this literature. When these accounts are considered in isolation, as is more commonly the case, it is easy to overlook that virtually all accounts depend on one of very few basic principles and that the proliferation of accounts can be understood as efforts (...) to ameliorate the weaknesses of those few principles. In the earlier sections, I will lay out three inductive principles and the families of accounts of induction they engender. In later sections I will review standard problems in the philosophical literature that have supported some pessimism about induction and suggest that their import has been greatly overrated. In the final sections I will return to the proliferation of accounts of induction that frustrates efforts at a final codification. I will suggest that this proliferation appears troublesome only as long as we expect inductive inference to be subsumed under a single formal theory. If we adopt a material theory of induction in which individual inductions are licensed by particular facts that prevail only in local domains, then the proliferation is expected and not problematic. (shrink)

While there is no universal logic of induction, the probability calculus succeeds as a logic of induction in many contexts through its use of several notions concerning inductive inference. They include Addition, through which low probabilities represent disbelief as opposed to ignorance; and Bayes property, which commits the calculus to a ‘refute and rescale’ dynamics for incorporating new evidence. These notions are independent and it is urged that they be employed selectively according to needs of the problem at hand. It (...) is shown that neither is adapted to inductive inference concerning some indeterministic systems. (shrink)