Recent magnetic resonance imaging and pathological studies have indicated that axonal loss is a major contributor to disease progression in multiple sclerosis. 1 H magnetic resonance spectroscopy, through measurement of N -acetyl aspartate, a neuronal marker, provides a unique tool to investigate this. Patients with primary progressive multiple sclerosis have few lesions on conventional MRI, suggesting that changes in normal appearing white matter, such as axonal loss, may be particularly relevant to disease progression in this group. To test this hypothesis (...) NAWM was studied with MRS, measuring the concentration of N -acetyl derived groups. Single-voxel MRS using a water-suppressed PRESS sequence was carried out in 24 patients with primary progressive multiple sclerosis and in 16 age-matched controls. Ratios of metabolite to creatine concentration were calculated in all subjects, and absolute concentrations were measured in 18 patients and all controls. NA/Cr was significantly lower in NAWM in patients than in controls, as was the absolute concentration of NA. There was no significant difference in the absolute concentration of creatine between the groups. This study supports the hypothesis that axonal loss occurs in NAWM in primary progressive multiple sclerosis and may well be a mechanism for disease progression in this group. (shrink)

Spanish translation, introductory study and notes on Charles Leslie Stevenson’s “Persuasive Definitions”. Published in Stevenson, Charles L. “Definiciones persuasivas”. Quaderns de Filosofia, vol. VIII, n. 1 (2021), pp. 105–125. -/- [Introductory study published in Oya, Alberto. “Presentación. Las definiciones persuasivas según Charles L. Stevenson”. Quaderns de Filosofia, vol. VIII, n. 1 (2021), pp. 101–104].

A book on the problems of ethics from the perspective of language and meaning.

Current theories suggest that the brain is the sole source of mental illness. However, affective disorders, and major depressive disorder (MDD) in particular, may be better conceptualized as brain-body disorders that involve peripheral systems as well. This perspective emphasizes the embodied, multifaceted physiology of well-being, and suggests that afferent signals from the body may contribute to cognitive and emotional states. In this review, we focus on evidence from preclinical and clinical studies suggesting that afferent thermosensory signals contribute to well-being and (...) depression. Although thermoregulatory systems have traditionally been conceptualized as serving primarily homeostatic functions, increasing evidence suggests neural pathways responsible for regulating body temperature may be linked more closely with emotional states than previously recognized, an affective warmth hypothesis. Human studies indicate that increasing physical warmth activates brain circuits associated with cognitive and affective functions, promotes interpersonal warmth and prosocial behavior, and has antidepressant effects. Consistent with these effects, preclinical studies in rodents demonstrate that physical warmth activates brain serotonergic neurons implicated in antidepressant-like effects. Together, these studies suggest that (1) thermosensory pathways interact with brain systems that control affective function, (2) these pathways are dysregulated in affective disorders, and (3) activating warm thermosensory pathways promotes a sense of well-being and has therapeutic potential in the treatment of affective disorders. (shrink)

In this award-winning study of the _Phaedrus_, Charles Griswold focuses on the theme of "self-knowledge." Relying on the principle that form and content are equally important to the dialogue's meaning, Griswold shows how the concept of self-knowledge unifies the profusion of issues set forth by Plato. Included are a new preface and an updated comprehensive bibliography of works on the _Phaedrus_.

Originally published by Routledge in 1988, this pioneering collection of essays now features a new preface and updated bibliography by the editor, reflecting the most significant developments in Plato scholarship during the past decade.

A biography of the foremost Christian humanist of the Renaissance who devoted his life to uplifting man's condition through faith, reason, and education.

Philosophers have debated whether the advance directives of Alzheimer’s patients should be enforced, even if patients seem content in their demented state. The debate raises deep questions about the nature of human autonomy and personal identity. But it tends to proceed on the assumption that the advance directive’s terms are clear, whereas in practice they are often vague or ambiguous, requiring the patient’s healthcare proxy to make difficult judgment calls. This practical wrinkle raises its own, distinct but related, philosophical question: (...) what criteria may the proxy bring to bear when making such interpretive judgments on which the patient’s life may depend? After defending a general policy of enforcing advance directives on normative (rather than metaphysical) grounds, I argue that when advance directives are vague, a patient’s proxy may permissibly make her own fresh evaluation of the patient’s life as a whole and, in so doing, consider how the patient’s character as a demented person contributes or fails to contribute to that life. (shrink)

Based on an unfinished manuscript by the late philosopher Dallas Willard, this book makes the case that the 20th century saw a massive shift in Western beliefs and attitudes concerning the possibility of moral knowledge, such that knowledge of the moral life and of its conduct is no longer routinely available from the social institutions long thought to be responsible for it. In this sense, moral knowledge--as a publicly available resource for living--has disappeared. Via a detailed survey of main developments (...) in ethical theory from the late 19th through the late 20th centuries, Willard explains philosophy's role in this shift. In pointing out the shortcomings of these developments, he shows that the shift was not the result of rational argument or discovery, but largely of arational social forces--in other words, there was no good reason for moral knowledge to have disappeared. The Disappearance of Moral Knowledge is a unique contribution to the literature on the history of ethics and social morality. Its review of historical work on moral knowledge covers a wide range of thinkers including T.H Green, G.E Moore, Charles L. Stevenson, John Rawls, and Alasdair MacIntyre. But, most importantly, it concludes with a novel proposal for how we might reclaim moral knowledge that is inspired by the phenomenological approach of Knud Logstrup and Emmanuel Levinas. Edited and eventually completed by three of Willard's former graduate students, this book marks the culmination of Willard's project to find a secure basis in knowledge for the moral life. (shrink)

Psychologists can measure normalcy, define madness, develop therapeutic paradigms, and list the nuances of human behavior with utmost precision. We have biofeedback, psychometrics, psychoanalysis, cognitive therapy, positive psychology, behavior modification, and a host of deeply promising projects in the research and development pipeline. To be sure, our discipline has advanced accurate understanding of the soul's essential properties and has scientifically harnessed this knowledge to clinically mitigate the deep agony of the human mind. But, despite our advances and genuine effectiveness, our (...) discipline remains incomplete. Theoretically, scientifically, and therapeutically, we fall short of the fuller effectuality that awaits us. We need Christ. It is through the Christian revelation that psychology will find its maturity. For psychology there are blessings afoot. These blessings stem from our recognition that the Clinical Christ - the activity of the God of the Christian revelation throughout the realms of our discipline - desires to redeem, relate, heal, love, and empower us. The chapters of this book explore different aspects of the Clinical Christ, Christian Holism, and their implications. A central tenet of Christian Holism is that the Holy Spirit is fully present in the clinical situation, with and within the therapist and the client, and is actively engaged in the treatment process. Ten further tenets proceeding from the central tenet are described. Other chapters include treatment of the importance of forgiveness, reconciliation and dream work in the practice of Christian Holism. There is copious material in other chapters citing significant research data validating health benefits of Christian prayer and spirituality, the need for the Church to restore the healing ministry and energetic components of Christian prayer and spirituality. (shrink)

Jean-Jacques Rousseau and Adam Smith are giants of eighteenth century thought. The heated controversy provoked by their competing visions of human nature and society still resonates today. Smith himself reviewed Rousseau's Discourse on Inequality, and his perceptive remarks raise an intriguing question: what would a conversation between these two great thinkers look like? In this outstanding book Charles Griswold analyses, compares and evaluates some of the key ways in which Rousseau and Smith address what could be termed "the question (...) of the self." Both thinkers discuss what we are by nature, who we have become, whether we can know ourselves or each other, how best to articulate the human condition, what it would mean to be free, and whether there is anything that can be done to remedy our deeply imperfect condition. In the course of examining their rich and contrasting views, Griswold puts Rousseau and Smith in dialogue by imagining what they might say in reply to one another. Griswold's wide-ranging exploration includes discussion of issues such as narcissism, self-falsification, sympathy, the scope of philosophy, and the relation between liberty, religion and civic order. A superb exploration of two major philosophers, Jean-Jacques Rousseau and Adam Smith: A Philosophical Encounter is essential reading for students and scholars of these two figures, eighteenth century philosophy, the Enlightenment, moral philosophy, the history of ideas. It will also be of interest to those in related disciplines such as political theory, economics, and religion. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Philosophy and Literature 26.1 (2002) 84-106 [Access article in PDF] Irony in the Platonic Dialogues Charles L. Griswold, Jr. I INTERPRETERS OF PLATO have arrived at a general consensus to the effect that there exists a problem of interpretation when we read Plato, and that the solution to the problem must in some way incorporate what has tendentiously been called the "literary" and the "philosophical" sides of Plato's (...) writing. The problem is created by the fact that Plato wrote in dialogue form, indeed a specific type of dialogue form. The solution must somehow combine into a coherent theory of the "meaning" of the dialogues, the ways in which these texts work (such as the use of imagery, metaphor, myth, allusion, irony, as well as argument). At the same time, there exists enormous disagreement about how one ought to move from these general observations to interpretation of a particular text. 1The problem of interpretation lies not merely in the fact that Plato wrote dialogues. That alone would not necessarily present any hermeneutical issues of unusual difficulty. Plato's distinctive use of the dialogue form creates the difficulties. The genre that we might call "the Platonic dialogue" is distinguished by several relevant characteristics.First, there is no character called "Plato" who speaks in any of the dialogues; indeed, "Plato" is mentioned twice in the entire corpus, once as being absent (Pho. 59b10), and once as being present (Apol. 38b6). Authorial anonymity is thus an important feature of the dialogues. 2 At least ab initio, we are not justified in identifying Plato with any one of his characters. Indeed, there are positive reasons why he cannot be identified even with Socrates, as I will discuss below. 3 Plato is absent from his own texts; no simple act of reading them will allow us to ascertain what his views are. 4 It does not follow that Plato's views are [End Page 84] entirely absent from the dialogues—say, in the form of some mysterious "esoteric teaching"—and that they cannot be elicited by a complex act of reading. Just how Plato's views are to be extracted has been, again, the subject of a very long debate. 5 I myself think that Plato's views can be so elicited. 6 But the fact of his anonymity as author means that "Plato's meaning" is not ascertainable in the way that, say, "Kant's meaning" may be ascertainable in the Critique of Pure Reason.A second feature of Plato's dialogues contributes to the interpretive puzzle. The dialogues are clearly fictional in character. They are not—they could not be—transcriptions of conversations which took place. Some dialogues could not have taken place even when the interlocutors were historical figures (for example, at the Phaedrus' ostensible dramatic date the real Phaedrus was not in Athens). Not only are many of the characters entirely fictional, there is clear evidence that even "Socrates" is very much a fictionalized version of the historical character. I am referring not just to the famous statement in the (possibly inauthentic) Second Letter, 7 but to the fact that the Socrates of Plato's dialogues is presented as being a super-human character. This is evident from Alcibiades' description of him in the Symposium as well as from a number of subtle fictions. For example, Plato has Socrates narrate the entirety of the Republic from memory, without a single moment of hesitation or (so far as the reader can tell) any lapse of memory. This fantastic feat is complemented by Socrates' equally fantastic stamina in conversation. The lengthy Protagoras, for example, is narrated in its entirety by Socrates immediately after the dialogue itself has occurred. Socrates never shows any fatigue of any sort. It is not just hyperbole to say that Plato's Socrates is heroic; he is carefully compared, in passages I cannot examine here, to both Achilles and Odysseus. Socrates' absolute calm and self-control before death also evidence his superhuman character. The relation between the historical Socrates and the Platonic Socrates is the source of much fruitful controversy. It suffices for... (shrink)

Features the full text of "Wittgenstein and Kierkegaard: Religion, Individuality and Philosophical Method," by Charles L. Creegan. Discusses the works and theories of Danish philosopher Soren Kierkegaard (1813-1855) and British philosopher Ludwig Wittgenstein (1889-1951).

In hospital rooms across the country, doctors, nurses, patients, and their families grapple with questions of life and death. Recently, they have been joined at the bedside by a new group of professional experts, bioethicists, whose presence raises a host of urgent questions. How has bioethics evolved into a legitimate specialty? When is such expertise necessary? How do bioethicists make their decisions? And whose interests do they serve? Renowned sociologist Charles L. Bosk has been observing medical care for thirty-five (...) years. In What Would You Do? he brings his extensive experience to bear on these questions while reflecting on the ethical dilemmas that his own ethnographic research among surgeons and genetic counselors has provoked. Bosk considers whether the consent given to ethnographers by their subjects can ever be fully voluntary and informed. He questions whether promises of confidentiality and anonymity can or should be made. And he wonders if social scientists overestimate the benefits of their work while downplaying the risks. Vital for practitioners of both the newly prominent field of bioethics and the long-established craft of ethnography, What Would You Do? will also engross anyone concerned with how our society addresses difficult health care issues. (shrink)

In this book, eminent scholars of classical antiquity and ancient and medieval Judaism and Christianity explore the nature and place of forgiveness in the pre-modern Western world. They discuss whether the concept of forgiveness, as it is often understood today, was absent, or at all events more restricted in scope than has been commonly supposed, and what related ideas may have taken the place of forgiveness. An introductory chapter reviews the conceptual territory of forgiveness and illuminates the potential breadth of (...) the idea, enumerating the important questions a theory of the subject should explore. The following chapters examine forgiveness in the contexts of classical Greece and Rome; the Hebrew Bible, the Talmud, and Moses Maimonides; and the New Testament, the Church Fathers, and Thomas Aquinas. (shrink)

The Demise of California's “Master Plan for Higher Education”After buying a home, a university education is the largest financial investment that most Americans ever make. Universities provide the learning environment to produce an informed electorate, support basic research and train professionals. A college education prepares a skilled workforce but, above all, the main purpose of higher education is to create and transmit knowledge, promote critical thinking and literacy, and prepare students to be enlightened, active citizens. California taxpayers generally considered public (...) higher education one of the best investments they could make in the future of their state. Since 1960…. (shrink)