Dewey's 1896 paper, "The Reflex Arc Concept in Psychology," was acclaimed 50 years later as the most important paper published in The Psychological Review in its first half-century of history. Today, Dewey's paper appears to be headed toward oblivion. Considering it worthy of resurrection, we use it as a starting point for tracing out the gradual evolution of Dewey and Bentley's formulation of their transactional viewpoint to its culmination in their book, Knowing and the Known. An exposition of the transactional (...) paradigm is developed via competing, contemporary self-actional and interactional theoretical systems. Then, the space-time postulates of self-actional, interactional, and transactional approaches are spelled out as they enter into philosophical, biological and psychological inquiry. Among prevailing theories, most of which fall into the self-actional/interactional categories, Kantor's interbehavioral viewpoint stands apart from the rest. And while it shares a certain similarity with the transactional approach, the historical record should document it as an independent and parallel development, dating back to Kantor's first publications almost seven decades ago. Furthermore, Kantor's system goes far beyond Dewey and Bentley's "unfractured observation," by providing highly refined analytic procedures in his theoretical constructs. (shrink)

The Malabo Declaration places the transformation of agriculture and food systems at the centre of regional and national policy priorities across Africa. Transformative change in the way that food is produced, processed and consumed is seen as not only necessary for addressing the complex challenges of food security and poverty alleviation, but also as a driver of new employment opportunities and economic development. As pointed out within the recent UN Food Systems Summit, essential elements of food system transformations include digital (...) transitions and the empowerment of women and youth. However, there are few empirical examples demonstrating how these agendas come together to affect food system change. Here we focus on an enterprising group of young farmers referred to as Malawi’s _new achikumbe elite_, who are urban based, educated and engaging in agriculture on a commercial basis. The aim is to characterise this emergent group of agriculturalists and to understand the role that they have within the transformation of Malawi-s agricultural sector. We explore how digital platforms are supporting the emergence of this new category of farmer and positioning young people as agents of change in food systems transformation. Based on interviews and ethnographic research with 32 young farmers between 2018 and 2022 combined with interviews with representatives of service providers and agricultural organisations, we argue that this group is characterised by a higher level of education, self-dependency and use of digital platforms, enabling them to adapt their context to sourcing production resources and engaging in commercial agriculture. We present evidence that digital platforms are supporting the new achikumbe elite (NAE) to engage flexibly with new commercial markets, contracts and access a wider range of training and advice. However, while digital platforms can offer more equitable access to information and market opportunities, they also represent potential avenues for food system transformations that are inequitable. As such, we argue that there is need for digital technologies to mitigate against potential inequalities. (shrink)

The US neutrino community gathered at the Workshop on the Intermediate Neutrino Program at Brookhaven National Laboratory February 4-6, 2015 to explore opportunities in neutrino physics over the next five to ten years. Scientists from particle, astroparticle and nuclear physics participated in the workshop. The workshop examined promising opportunities for neutrino physics in the intermediate term, including possible new small to mid-scale experiments, US contributions to large experiments, upgrades to existing experiments, R&D plans and theory. The workshop was organized into (...) two sets of parallel working group sessions, divided by physics topics and technology. Physics working groups covered topics on Sterile Neutrinos, Neutrino Mixing, Neutrino Interactions, Neutrino Properties and Astrophysical Neutrinos. Technology sessions were organized into Theory, Short-Baseline Accelerator Neutrinos, Reactor Neutrinos, Detector R&D and Source, Cyclotron and Meson Decay at Rest sessions.This report summarizes discussion and conclusions from the workshop. (shrink)

Cyclin-dependent kinase 5 has been implicated in Alzheimer's disease pathogenesis. Here, we demonstrate that overexpression of p25, an activator of cdk5, led to increased levels of BACE1 mRNA and protein in vitro and in vivo. A p25/cdk5 responsive region containing multiple sites for signal transducer and activator of transcription was identified in the BACE1 promoter. STAT3 interacts with the BACE1 promoter, and p25-overexpressing mice had elevated levels of pSTAT3 and BACE1, whereas cdk5-deficient mice had reduced levels. Furthermore, mice with a (...) targeted mutation in the STAT3 cdk5 responsive site had lower levels of BACE1. Increased BACE levels in p25 overexpressing mice correlated with enhanced amyloidogenic processing that could be reversed by a cdk5 inhibitor. These data demonstrate a pathway by which p25/cdk5 increases the amyloidogenic processing of APP through STAT3-mediated transcriptional control of BACE1 that could have implications for AD pathogenesis. (shrink)

Many individuals with developmental language disorder (DLD) and individuals who are deaf or hard of hearing (D/HH) have social–emotional problems, such as social difficulties, and show signs of aggression, depression, and anxiety. These problems can be partly associated with their executive functions (EFs) and theory of mind (ToM). The difficulties of both groups in EF and ToM may in turn be related to self-directed speech (i.e., overt or covert speech that is directed at the self). Self-directed speech is thought to (...) allow for the construction of non-sensory representations (i.e., representations that do not coincide with direct observation). Such non-sensory representations allow individuals to overcome the limits set upon them by the senses. This ability is constrained by the development of word meaning structure (i.e., the way words are understood). We argue that the greater ability to construct non-sensory representations may result in more enhanced forms of EF and ToM. We conclude that difficulties in EF, ToM, and social–emotional functioning in those with hearing and language problems may be accounted for in terms of word meaning impairments. We propose that word meaning structure and self-directed speech should be considered in assigning EF and ToM treatments to individuals with DLD and those who are D/HH. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:F. H. Bradley and the Working-out of Absolute Idealism* JOHN HERMAN RANDALL, JR. FRANCIS HERBERTBRADLEY (1846-1924) 1 agreed with the other English idealists that the real world is the experienced world. But he started with the fundamental conviction that "experience" is more than "thought," as Green had maintained. Bradley's basic drive is the refusal to abolish "feeling" in favor of knowledge and intelligibility. "Feeling" is a fundamental and (...) ineradicable aspect of "reality"m more fundamental, in fact, than thinking. In the immediately experienced world, all intelligible distinctions and relations are merged in a "whole of feeling" which is the ultimate subject-matter of philosophy. "Thought" arises out of feeling, out of "immediacy," as an interpretation of immediate experience by distinguishing relations and aspects in it. "Knowledge " is only one aspect of the experienced world; it needs blending with "feeling" and will to include all the experienced aspects. "Feeling" starts for Bradley, in his Principles of Logic (1883), in pretty much the empiricist sense, as isolated sensations, and as subjective (in flavor at least). It then becomes neutral: "feeling" is identified with "the felt"; and it grows richer, attempting to include the whole wealth of immediate experience. Thus Bradley gets very close to Dewey's conception of "direct experience," "non-reflective experience," without, however, Dewey's biological analysis. It is through this conception of experience that Bradley approaches the naturalism to which his thinking almost arrived at the end. Thought, that is, has a setting in experience " it is relational, and by its analysis it breaks up experienced and felt wholes. There is a double insistence in Bradley. On the one hand, reality is experienced, but is not adequately expressed in thought. On the other, reality/s accessible to knowledge. What has often been called Bradley's "skepticism" is really an objective relativism. Thought, logical structure, is not ultimate. In Appearance and *This study of F. It. Bradley is based on one of five chapters on post-ttegehan philosophical Ideahsm in Britain and America to be included in my forthcoming Career oJ Philosophy in Modem Times, Vol.III: The Hundred Years Since Darwin. ISee Bradley ed. of Mind, XXXIV (1925); A. E. Taylor, "F. H. Bradley"; J. H. Muirhead, "Bradley's Place in Philosophy." See also T. M. Forsyth, English Philosophy (London: 1910), chap. VII, 2rid part; Rudolf Kagey, F. H. Bradley's Logic (New York: 1931). The best philosophical analyses of Bradley are Robert D. Mack, The Appeal to Immediate Experience (New York: 1945),and Richard Wollheim,F. H. Bradley (Pelican Books, 1959). [245] 246 HISTORY OF PHILOSOPHY Reality, he insists it is really self-contradictory; then later he emphasizes rather that it is always relative to its particular subiect-matter. The real, experienced world is never identical with the intelligible world, yet it is also never "extraneous " to it. The relation of the two can be said to be, in Aristotelian terms, that of substance to form, that of what is to its intelligible aspect. The intelligible world, the system of science and knowledge, thus fundamentally needs criticism in the light of its setting in the experienced world. This is not only the entire drive of Dewey's Experience and Nature; it is the expression of that whole current of thought on the Continent which began with the criticism of Hegel's "panlogism" in the 1840's and is today called "Existentialism." Bradley is the British counterpart of all those who have criticized philosophies of logical structure like T. H. Green's, or like the other contemporary forms of Neo-Kantianism in Germany and France. The "known world" is a world of relations distingflished in the richer "real world." These distinctions are ultimately relative to their particular setting, but in that setting they are valid enough. Bradley's celebrated doctrine of the "degrees of truth and reality" means that practically knowledge is "true"; any idea which fulfills its purpose of rendering some portion or aspect of experience intelligible and significant and meaningful, and which is not ousted by a better idea, Bradley is willing to say is "so far true." It is valid, in its own sphere and purpose, despite its ultimate inconsistency; the wave-theory... (shrink)

Modernite et tradition? Modernite ou tradition? Que faire de cette question, elle-meme eminemment moderne? Dans le present recueil, l'auteur tente d'avancer une reponse nuancee. Il refuse de muer les termes-cle de la question initiale - modernite et tradition - en un couple antithetique. Il se situe plutot et deliberement dans un fragile entre-deux culturel et conceptuel permettant de decouvrir, d'explorer et d'accepter aussi la mince frontiere a la fois intellectuelle, morale et quotidiennement vecue ou se rencontrent sans cesse modernite et (...) tradition. Une rencontre - les essais reunis dans ce volume le montrent a suffisance - inevitable mais pas forcement dramatique comme d'aucuns le voudraient. La conclusion? Suivant l'auteur, la modernite est condamnee, simplement, a rester jusqu'a un certain degre traditionnelle, a tout jamais, et elle a a thematiser cette appartenance culturelle, religieuse et sociopolitique. Sinon, il sera impossible de sortir de cette impasse qu'est le 'malaise de la modernite'. Apres une reflexion preliminaire poussee sur la problematique centrale du livre - modernite et desenchantement -, l'auteur s'arrete longuement a deux penseurs qui, grace a leur maniere de penser resolument moderne et surprenante, ont conserve cette etrange et envoutante capacite d'emerveiller le lecteur contemporain: Spinoza et Hume. Dans ces oeuvres d'une profondeur et d'une perspicacite admirables se voient thematises certains aspects fondamentaux de la culture tant traditionnelle que moderne comme la religion, la science, l'ethique et le sens commun. La partie subsequente a alors pour but de mieux cerner les multiples rapports entre modernite et tradition. La derniere partie du recueil traite de deux questions actuelles, celles notamment de la soi-disant "fin de l'histoire" (Fukuyama) et de la "crise de la societe occidentale". L'enjeu de cette reflexion plutot ethico-politique reste le meme qu'ailleurs: y-a-t-il moyen de jeter un pont entre modernite et tradition, d'aboutir a une synthese nuancee et viable? Ce que ce livre ambitionne en fin de compte? L'auteur se propose de fournir aux lecteurs les ebauches d'une philosophie moderne et pourtant aussi fort sensible a tout ce que la tradition nous a legue, comme un don presque. Pour y arriver, il essaie de penser et d'ecrire depuis un entre-deux ou s'entrecroisent le premoderne et le moderne ainsi que deux styles philosophiques juges souvent et a tort antinomiques, les philosophies analytique et continentale. (shrink)

Pain may appear to undermine the radically intentionalist view that the phenomenal character of any experience is entirely constituted by its representational content. That appearance is illusory. After categorizing versions of pain intentionalism along two dimensions, I argue that an 'objectivist' and 'non-mentalist' version is the most promising, if it can withstand two objections concerning what we say when in pain, and the distinctiveness of pain. I rebut these objections, in a way available to both opponents of and adherents to (...) the view that experiential content is entirely conceptual. (shrink)

The self seems to be a unitary entity remaining stable across time. Nevertheless, current theorizing conceptualizes the self as a number of interacting sub-systems involving perception, intention and action (self-model). One important function of such a self-model is to distinguish between events occurring as a result of one's own actions and events occurring as the result of somebody else's actions. We conducted an fMRI experiment that compared brain activation after an abrupt mismatch between one's own movement and its visual consequences (...) with an abrupt mismatch between one's own movement and somebody else's visually perceived hand movement. A right fronto-parietal network was selectively active during a sudden mismatch between one's own observed and performed hand action. (shrink)

This Paper Offers A New Interpretation of Phaedo 96a–103a. Plato has devoted the dialogue up to this point to a series of arguments for the claim that the soul is immortal. However, one of the characters, Cebes, insists that so far nothing more has been established than that the soul is durable, divine, and in existence before the incarnation of birth. What is needed is something more ambitious: a proof that the soul is not such as to pass out of (...) existence. According to Socrates’s initial response to Cebes at 95e8–96a1, giving such a demonstration requires a thorough investigation into “the reason for coming to be and passing away in general” (ὅλως γὰϱ δεῖ πεϱὶ γενέσεως ϰαὶ Φθοϱᾶς τὴν αἰτίαν διαπϱαγματεύσασθαι .. (shrink)

Jehovah's Witnesses are students of the Bible. They refuse transfusions out of obedience to the scriptural directive to abstain and keep from blood. Dr Muramoto disagrees with the Witnesses' religious beliefs in this regard. Despite this basic disagreement over the meaning of Biblical texts, Muramoto flouts the religious basis for the Witnesses' position. His proposed policy change about accepting transfusions in private not only conflicts with the Witnesses' fundamental beliefs but it promotes hypocrisy. In addition, Muramoto's arguments about pressure to (...) conform and coerced disclosure of private information misrepresent the beliefs and practices of Jehovah's Witnesses and ignore the element of individual conscience. In short, Muramoto resorts to distortion and uncorroborated assertions in his effort to portray a matter of religious faith as a matter of medical ethical debate. (shrink)

Dictionary of Viśiṣṭādvaita school in Hindu philosophy.

In this rehabilitation of the relational transaction of compromising, we follow Paul Ricoeur in arguing that at the intersection of diverse orders of value, compromising rises to the level of a moral duty. Thus, an ethics of compromise, rooted in recognition theory, provides a virtuous means of moral engagement with otherness in the context of pluralism. Virtue theory needs to move in an interactive direction by enlisting moral epistemology, for a shift in focus from the individual agent to the interaction (...) of agents ; attending to the political theorists and sociologists who ground meaningful compromise in mutual recognition; and tailoring such recognition to bounded human capacities for rationality and empathy, via "psychological realism"—all in service of attenuating the discomfort and even moral pain that agents may feel when called upon to compromise. (shrink)

In this paper, I attempt to explain one of the most controversial views attributed to the Stoic Chrysippus: that the impossible can follow from the possible. My solution finds in Chrysippus a distinction later made by the medieval logician John Buridan: that between being possible (there being a state of affairs that may occur) and being possibly-true (there being some proposition whose truth-conditions are that state of affairs). Buridan and Chrysippus have radically opposing views on the nature of propositions. What (...) their conceptions share is the conclusion that at least some propositions must be contingent beings. They argue for this while maintaining a rigorous commitment to the view that propositions are strictly bivalent. In 2. I explain the Chrysippean passage in terms of a distinction Buridan makes explicitly. In 3. I show how the distinction follows implicitly from the Stoic theory of quantification. In 4. I compare the modality with other aspects of Stoic logic. In 5. I discuss how the distinction behaves in the future tense. (shrink)

The papers in this volume bring together a number of scholars working on topics ranging from contemporary ethics to the history of philosophy. This wide scope reflects the comprehensive nature of Dietrich von Hildebrand's philosophic vision. His career includes foundational works on such subjects as ethics, philosophical method, aesthetics, and the nature of love. One struggles to imagine how Hildebrand managed to fit all this into a life that also includes extensive anti-Nazi political activism during World War II. Within this (...) broad scope of Hildebrand's work, one finds a number of important philosophical problems that beg for further development, such as his conception of personal existence, his rich and pluralistic conception of beauty, or his distinction between person and personality. In several places, however, the development of Hildebrand's thought must involve a correction or even an outright challenge to his reasoning. Each of these papers does just this, applying the insights of Hildebrand to a number of diverse philosophical problems, while also advancing and challenging his thought in various ways. Despite this wide diversity, three central issues appear again and again in these papers, and represent some of Hildebrand's most important contributions to philosophy: (i) his method of phenomenological realism, (ii) his conception of value and value-response, and (iii) his personalism. I want to provide here a brief sketch of these three areas to orient the reader before approaching the more technical details of each essay. (shrink)

In the basic modal language and in the basic modal language with the added universal modality, first-order definability of all formulas over the class of all frames is shown. Also, it is shown that the problems of modal definability of first-order sentences over the class of all frames in the languages and are both PSPACE-complete.