Simple epithelial keratins K8 and K18 are components of the intracellular cytoskeleton in the cells of the single‐layered sheet tissues inside the body. As members of the intermediate filament family of proteins, their function has been a matter for debate since they were first discovered. Whilst there is an indisputable case for a structural cell‐reinforcing function for keratins in the mutilayered squamous epithelia of external barrier tissues, some very different stress‐protective features now seem to be emerging for the simple epithelial (...) keratins. Even the emerging evidence of pathological mutations in K8/K18 looks very different from mutations in stratified epithelial keratins. K8/K18‐like keratins were probably the first to evolve and, whilst stratified epithelial (keratinocyte) keratins have diversified into a large group of keratins highly specialised for providing mechanical stability, the simple epithelial keratins have retained early features that may protect the internal epithelia from a broader range of stresses, including osmotic stress and chemical toxicity. BioEssays 25:748–758, 2003. © 2003 Wiley Periodicals, Inc. (shrink)

Left-wing authoritarianism remains far less understood than right-wing authoritarianism. We contribute to literature on the former, which typically relies on surveys, using a new social media analytic approach. We use a list of 60 terms to provide an exploratory sketch of the outlines of a political ideology – tribal equalitarianism – with origins in 19th and 20th century social philosophy. We then use analyses of the English Corpus of Google Books (n > 8 million books) and scraped unique tweets from (...) Twitter (n = 202,582) to conduct a series of investigations to discern the extent to which this ideology is cohesive amongst the public, reveals signatures of authoritarianism and has been growing in popularity. Though exploratory, our results provide some evidence of left-wing authoritarianism in two forms: (1) a uniquely conservative signature amongst ostensible liberals using measures derived from Moral Foundations Theory and (2) a substantial prevalence of anger, relative to anxiety or sadness, in tweets analyzed for sentiment. In general, results indicate that this worldview is growing in popularity, is increasingly cohesive, and shows signatures of authoritarianism. (shrink)

Sexual behaviour and mate choice are key intervening variables between attachment and life histories. We propose a set of predictions relating attachment, reproductive strategies, and mate choice criteria.

Children and adults from theus and China heard about people who died in two types of narrative contexts – medical and religious – and judged whether their psychological and biological capacities cease or persist after death. Most 5- to 6-year-olds reported that all capacities would cease. In theus, but not China, there was an increase in persistence judgments at 7–8 years, which decreased thereafter.uschildren’s persistence judgments were influenced by narrative context – occurring more often for religious narratives – and such (...) judgments were made especially for psychological capacities. When participants were simply asked what happens to people following death, in both countries there were age-graded increases in references to burial, religious ritual, and the supernatural. (shrink)

Contemporary research highlights multiple societal and environmental benefits in addition to potential economic advantages associated with renewable energy utilization. As federal and state incentives for investments in RE technologies become more prevalent, RE sources represent increasingly viable alternatives to established fossil fuel energy. RE utilization is recognized as a key component of “green” product innovation that helps firms reduce the environmental impact of production processes and diminish their ecological footprints and energy consumption. Yet, despite consistent evidence that corporate sustainability initiatives (...) are favorably associated with firm performance, the limited research that examines associations between RE initiatives and firm performance yields mixed results and an explicit link has yet to be established. Drawing on the natural resource-based view of the firm, we examine the association between RE utilization and firm financial performance over time. Annual ROI, Tobin’s Q, and operating margin for large U.S. firms identified as exceptional users of RE in the EPA’s Fortune 500 Top Green Power Partners list are compared with their respective industry medians over a 7-year period and post hoc bootstrapping and sensitivity analyses are performed to further validate the study findings. Our research advances current knowledge about the influence of RE utilization by demonstrating that top RE user firms consistently generated superior financial performance compared to their industry competitors. As such, the study findings lend credence to the existence of a business case that complements the societal and environmental benefits of RE utilization. (shrink)

Since the mid?1960s in advanced and rapidly advancing economies, there has been a rising tide of clinical depression and dysphoria, a decline in mutual trust, and a loosening of social bonds. Most studies show that above a minimal level, income is irrelevant to one's sense of well?being, but companionship and social support increase well?being. Since shopping and consumption are increasingly solitary activities, and watching television is not genuinely sociable, the increased time devoted to these activities may be responsible for rising (...) levels of depression. Advanced societies are likely to increase ?utility? if they maximize friendship rather than the getting and spending of wealth. (shrink)

The use of modeling and simulation methodologies is growing rapidly across the psychological and social sciences. After a brief introduction to the relevance of computational methods for research on human cognition and culture, we describe the sense in which computer models and simulations can be understood, respectively, as “theories” and “predictions.” Most readers of JoCC are interested in integrating micro- and macro-level theories and in pursuing empirical research that informs scientific predictions, and we argue that M&S provides a powerful new (...) set of tools for pursuing these interests. We also point out the way in which M&S can help scholars of cognition and culture address four key desiderata for social scientific research related to the themes of clarity, falsifiability, dynamicity, and complexity. Finally, we provide an introduction to the other papers that comprise this special issue, which includes contributions on topics such as the role of M&S in interdisciplinary debates, shamanism, early Christian ritual practices, the emergence of the Axial age, and the social scientific appropriation of algorithms from massively multiplayer online games. (shrink)

People are excused from moral blame for the harm they are said to have caused if they could not have done otherwise. Such excuses rely on causal explanations deriving mostly from social and biological sciences whose paradigms are probabilistic, disjunctive, and combine dispositional and circumstantial factors according to the variance accounted for by each type of factor. The more complete the explanation, the less choice the harm-doer seems to have and therefore the less moral blame is warranted. Thus, the biological (...) bases of people’s behaviour, their earlier socialization, and their prior choices reduce the scope and severity of moral blame — but have no effect on judgments of right and wrong. Fairness also requires a similar analysis of the behaviour of moral judges whose standards vary with their dispositions, social class, and culture. It follows that moral assessments are joint products of both ethics and the social and biological sciences, with neither group able to make fair moral assessments of people’s behaviour without help from the other. (shrink)

If the obstacles to human development lie in the paucity of resources, in insuperable technical barriers, the task would be hopeless. We know instead that it is too often a lack of political commitment, not of resources, that is the ultimate cause of human neglect. United Nations, Human Development Report, 1991.

Rational choice theories have been falsified by experimental tests of economic behavior and have not been supported by analyses of behavior in the market. Politics is an even less fertile field of application for rational choice theories because politics deals with ends as well as means, thus preventing ends?means rationality; voters have partisan loyalties often ?fixed? in adolescence; political benefits have no common unit of measurement; ?rational ignorance? inhibits rational choices; and there is no market?like feedback to facilitate learning. Research (...) comparing public and private efficiency does not support rational choice. Ironically, while law and business schools are now employing better microeconomic theories, political scientists are taking up rational choice theory, regardless of the disconfirming evidence. (shrink)

In this study we examined the applicability of personality measures to assessing God representations, and we explored how the overlap between personality judgments of self and God relate to strength of (dis)belief and closeness to God among atheists and agnostics. Using sample of 1,088 atheists/agnostics, we applied Goldberg’s Big Five bipolar markers as a standardized measure of personality dimensions, along with measures of identity fusion with God, belief strength, and sociosexuality, as this trait has been shown to be relevant in (...) predicting religiosity. Our study revealed that personality measures can be used for research on the personality of supernatural agents. We also found that personality self-assessments were related to the assessments of God personality. Agreeableness was positively related to the perception of emotional stability of God, while conscientiousness and surgency were negatively related to perceived intellect and surgency of god, respectively. Also, intellect of the participants was related negatively to perceptions of God’s emotional stability and intellect. Perceived distance between the assessment of one’s own personality and the personality of God predicted the strength of (dis)belief, thus opening new interpretations into possible sources of belief and disbelief. Finally, echoing previous studies, we found that conscientiousness of God had a negative effect on SOI-R score. (shrink)

If the obstacles to human development lie in the paucity of resources, in insuperable technical barriers, the task would be hopeless. We know instead that it is too often a lack of political commitment, not of resources, that is the ultimate cause of human neglect. United Nations, Human Development Report, 1991.

Wilson's comments on The Market Experience are deficient for at least three reasons. First, his lack of knowledge regarding subjective well?being deprives him of an adequate frame of reference from which to evaluate my work. Second, he fails to appreciate that a theory may legitimately draw upon more than one explanatory factor. Third, Wilson apparently did not read the entire book.

The past two decades have seen a growing interest in evolutionary and scientific approaches to religion. The Routledge Handbook of Evolutionary Approaches to Religion is an outstanding reference source to the key topics, problems and debates in this exciting and emerging field. Comprising over thirty chapters by a team of international contributors the handbook pulls together scholarship in the following areas: evolutionary psychology and the cognitive science of religion (CSR), cultural evolution and the complementarity of evolutionary psychology, cognitive science and (...) cultural evolution. Within these sections central issues, debates and problems are examined, including: Cliodynamics, cultural group selection, costly signalling, dual inheritance theory, literacy, transmitting narratives, prosociality, supernatural punishment, cognition and ritual, meme theory, fusion theory, sexual selection, agency detection, evoked culture, social brain hypothesis, theory of mind, developmental psychology, emergence theory, social learning, cultural cybernetics, cultural epidemiology, evolutionary and cultural psychology, memetics, by-product and adaptationist theories of religion, systems and information theory, and computer modelling. This is essential reading for students and researchers in religious studies and anthropology, the Handbook will also be very useful to those in related fields, such as psychology, sociology of religion, cognitive biology, and evolutionary biology. (shrink)

Many of the most virulent and problematic eukaryotic pathogens have evolved from photosynthetic ancestors, such as apicomplexans, which are responsible for a wide range of diseases including malaria and toxoplasmosis. The primary barrier to understanding the early stages of evolution of these parasites has been the difficulty in finding parasites with closely related free‐living lineages with which to make comparisons. Parasites found throughout the florideophyte red algal lineage, however, provide a unique and powerful model to investigate the genetic origins of (...) a parasitic lifestyle. This is because they share a recent common ancestor with an extant free‐living red algal species and parasitism has independently arisen over 100 times within this group. Here, we synthesize the relevant hypotheses with respect to how these parasites have proliferated. We also place red algal research in the context of recent developments in understanding the genome evolution of other eukaryotic photosynthesizers turned parasites. (shrink)

In this comprehensive collection of essays, most of which appear for the first time, eminent scholars from many disciplines—philosophy, economics, sociology, political science, demography, theology, history, and social psychology—examine the causes, nature, and consequences of present-day consumption patterns in the United States and throughout the world.

Debates over the causes and consequences of the “Axial Age” – and its relevance for understanding and explaining “modernity” – continue to rage within and across a wide variety of academic disciplines, including anthropology, sociology, archaeology, history, social theory, and cognitive science. We present a computational model that synthesizes three leading theories about the emergence of axial civilizations. Although these theories are often treated as competitors, our computational model shows how their most important conceptual insights and empirically based causal claims (...) can be integrated within a single computational architecture. The plausibility of the latter is supported by the results of our simulation experiments, which were able to simulate the emergence and growth of an axial civilization. The model shows how the relevant theories can be rendered consistent, while challenging the claims of any one to comprehensiveness. (shrink)

Despite their diversity and ecological importance, many areas of the SAR—Stramenopila, Alveolata, and Rhizaria—clade are poorly understood as the majority of SAR species lack molecular data and only 5% of species are from well-sampled families. Here, we review and summarize the state of knowledge about the three major clades of SAR, describing the diversity within each clade and identifying synapomorphies when possible. We also assess the “dark area” of SAR: the morphologically described species that are missing molecular data. The majority (...) of molecular data for SAR lineages are characterized from marine samples and vertebrate hosts, highlighting the need for additional research effort in areas such as freshwater and terrestrial habitats and “non-vertebrate” hosts. We also describe the paucity of data on the biogeography of SAR species, and point to opportunities to illuminate diversity in this major eukaryotic clade. See also the video abstract here: https://youtu.be/_VUXqaX19Rw. Despite their diversity, abundance, and importance, fewer than 10% of the species within the SAR—Stramenopila, Alveolata, and Rhizaria—clade have been assessed using molecular tools. Only a small percentage of the molecular records contain information on ecology or have associate location data, indicating a tremendous dark area. (shrink)

Previous research has suggested that bodily signals from internal organs are associated with diverse cortical and subcortical processes involved in sensory-motor functions, beyond homeostatic reflexes. For instance, a recent study demonstrated that the preparation and execution of voluntary actions, as well as its underlying neural activity, are coupled with the breathing cycle. In the current study, we investigated whether such breathing-action coupling is limited to voluntary motor action or whether it is also present for mental actions not involving any overt (...) bodily movement. To answer this question, we recorded electroencephalography (EEG), electromyography (EMG), and respiratory signals while participants were conducting a voluntary action paradigm including self-initiated motor execution (ME), motor imagery (MI), and visual imagery (VI) tasks. We observed that the voluntary initiation of ME, MI, and VI are similarly coupled with the respiration phase. In addition, EEG analysis revealed the existence of readiness potential (RP) waveforms in all three tasks (i.e., ME, MI, VI), as well as a coupling between the RP amplitude and the respiratory phase. Our findings show that the voluntary initiation of both imagined and overt action is coupled with respiration, and further suggest that the breathing system is involved in preparatory processes of voluntary action by contributing to the temporal decision of when to initiate the action plan, regardless of whether this culminates in overt movements. -/- . (shrink)

Current UK legislation is impacting upon the feasibility and cost-effectiveness of medical record-based research aimed at benefiting the NHS and the public heath. Whereas previous commentators have focused on the Data Protection Act 1998, the Health and Social Care Act 2001 is the key legislation for public health researchers wishing to access medical records without written consent. The Act requires researchers to apply to the Patient Information Advisory Group for permission to access medical records without written permission. We present a (...) case study of the work required to obtain the necessary permissions from PIAG in order to conduct a large scale public health research project. In our experience it took eight months to receive permission to access basic identifying information on individuals registered at general practices, and a decision on whether we could access clinical information in medical records without consent took 18 months. Such delays pose near insurmountable difficulties to grant funded research, and in our case £560 000 of public and charitable money was spent on research staff while a large part of their work was prohibited until the third year of a three year grant. We conclude by arguing that many of the current problems could be avoided by returning PIAG’s responsibilities to research ethics committees, and by allowing “opt-out” consent for many public health research projects. (shrink)

The American Constitution held out the hope that ordinary people were capable of deciding their own fates, and in doing so it immeasurably elevated the dignity of common people. The organization and interplay of the parts that comprise the whole American government exist to provide people the opportunity to govern themselves and, at the same time, reveal the limits of democratic self-rule. The forgetting of these limits is not only destructive to the constitution but the nation as a whole.

Despite their diversity and ecological importance, many areas of the SAR—Stramenopila, Alveolata, and Rhizaria—clade are poorly understood as the majority (90%) of SAR species lack molecular data and only 5% of species are from well‐sampled families. Here, we review and summarize the state of knowledge about the three major clades of SAR, describing the diversity within each clade and identifying synapomorphies when possible. We also assess the “dark area” of SAR: the morphologically described species that are missing molecular data. The (...) majority of molecular data for SAR lineages are characterized from marine samples and vertebrate hosts, highlighting the need for additional research effort in areas such as freshwater and terrestrial habitats and “non‐vertebrate” hosts. We also describe the paucity of data on the biogeography of SAR species, and point to opportunities to illuminate diversity in this major eukaryotic clade. (shrink)

Recent studies have demonstrated neural overlap between resting state activity and self-referential processing. This “rest-self” overlap occurs especially in anterior cortical midline structures like the perigenual anterior cingulate cortex (PACC). However, the exact neurotemporal and biochemical mechanisms remain to be identified. Therefore, we conducted a combined electroencephalography (EEG)-magnetic resonance spectroscopy (MRS) study. EEG focused on pre-stimulus (e.g., prior to stimulus presentation or perception) power changes to assess the degree to which those changes can predict subjects’ perception (and judgment) of subsequent (...) stimuli as high or low self-related. MRS measured resting state concentration of glutamate, focusing on PACC. High pre-stimulus (e.g., prior to stimulus presentation or perception) alpha power significantly correlated with both perception of stimuli judged to be highly self-related and with resting state glutamate concentrations in the PACC. In sum, our results show (i) pre-stimulus (e.g., prior to stimulus presentation or perception) alpha power and resting state glutamate concentration to mediate rest-self overlap that (ii) dispose or incline subjects to assign high degrees of self-relatedness to perceptual stimuli. (shrink)

Este trabalho analisa a importância da disciplina Filosofia no Ensino Médio em vista das atuais políticas públicas educacionais brasileira. Abordamos a Filosofia no Ensino Médio de acordo a Lei n.13.415/17 que alterou o Artigo 36 da Lei n. 9. 394/96 da Lei de Diretrizes e Bases da Educação Nacional-LDBEN, Lei n.11.648 de 2008, Resolução de n° 04 de 2010, as denominadas Diretrizes Curriculares Nacionais para o Ensino Médio e a Base Nacional Comum Curricular – BNCC/2017. Nesta pesquisa bibliográfica de caráter (...) qualitativo, conclui-se que os referidos documentos oficiais revelam além das alterações quanto ao lugar legado da Filosofia na formação integral do aluno, por ser colocada em segundo plano, a desvalorização de um conhecimento crítico e reflexivo com vistas a emancipação humana, pois a proposição do ensino está mais centrado em uma concepção de conservação da ordem dominante. (shrink)

Essays that put noted political thinkers of the past—including Plato, Machiavelli, Hobbes, Wollstonecraft, Marx, and Confucius—in dialogue with current environmental political theory. Contemporary environmental political theory considers the implications of the environmental crisis for such political concepts as rights, citizenship, justice, democracy, the state, race, class, and gender. As the field has matured, scholars have begun to explore connections between Green Theory and such canonical political thinkers as Plato, Machiavelli, Locke, and Marx. The essays in this volume put important figures (...) from the political theory canon in dialogue with current environmental political theory. It is the first comprehensive volume to bring the insights of Green Theory to bear in reinterpreting these canonical theorists. Individual essays cover such classical figures in Western thought as Aristotle, Hume, Rousseau, Mill, and Burke, but they also depart from the traditional canon to consider Mary Wollstonecraft, W. E. B. Du Bois, Hannah Arendt, and Confucius. Engaging and accessible, the essays also offer original and innovative interpretations that often challenge standard readings of these thinkers. In examining and explicating how these great thinkers of the past viewed the natural world and our relationship with nature, the essays also illuminate our current environmental predicament. Essays on Plato • Aristotle • Niccolò Machiavelli • Thomas Hobbes • John Locke • David Hume • Jean-Jacques Rousseau • Edmund Burke • Mary Wollstonecraft • John Stuart Mill • Karl Marx • W. E. B. Du Bois • Martin Heidegger • Hannah Arendt • Confucius Contributors Sheryl D. Breen, W. Scott Cameron, Peter F. Cannavò, Joel Jay Kassiola, Joseph H. Lane Jr. Timothy W. Luke, John M. Meyer, Özgüç Orhan, Barbara K. Seeber, Francisco Seijo, Kimberly K. Smith, Piers H. G. Stephens, Zev Trachtenberg, Andrew Valls, Harlan Wilson. (shrink)