Recent magnetic resonance imaging and pathological studies have indicated that axonal loss is a major contributor to disease progression in multiple sclerosis. 1 H magnetic resonance spectroscopy, through measurement of N -acetyl aspartate, a neuronal marker, provides a unique tool to investigate this. Patients with primary progressive multiple sclerosis have few lesions on conventional MRI, suggesting that changes in normal appearing white matter, such as axonal loss, may be particularly relevant to disease progression in this group. To test this hypothesis (...) NAWM was studied with MRS, measuring the concentration of N -acetyl derived groups. Single-voxel MRS using a water-suppressed PRESS sequence was carried out in 24 patients with primary progressive multiple sclerosis and in 16 age-matched controls. Ratios of metabolite to creatine concentration were calculated in all subjects, and absolute concentrations were measured in 18 patients and all controls. NA/Cr was significantly lower in NAWM in patients than in controls, as was the absolute concentration of NA. There was no significant difference in the absolute concentration of creatine between the groups. This study supports the hypothesis that axonal loss occurs in NAWM in primary progressive multiple sclerosis and may well be a mechanism for disease progression in this group. (shrink)

This paper aims to contribute to a greater understanding of the theory of virtue ethics and its applications in the business arena. In contrast to other prominent approaches to ethics, virtue ethics provides a useful perspective in making sense of various business ethics issues with an emphasis on the moral character of the individuals and its transformational influences in driving ethical business conduct. Building on Geoff Moore’s :19–32, 2002; Bus Ethics Q 15:237–255, 2005; Bus Ethics Q 18:483–511, 2008) treatment (...) of Alasdair MacIntyre’s practice–institution schema, the paper discusses how individuals, as moral agents, can serve to promote virtuous business conduct and help foster a moral and ethical climate in the organization and in society at large. Using interview data from a broader study of the New Zealand wine industry as explanatory examples, the paper argues that while many companies’ sustainable practices are still largely market based, such excellent business practices are often driven by individuals’ moral and ethical pursuits. (shrink)

Derided and disregarded by many of his contemporaries, Michel Foucault is now regarded as probably the most influential thinker of the twentieth century, his work is studied across the humanities and social sciences. Reading Foucault, however, can be a challenge, as can writing about him, but in Understanding Foucault, the authors offer an entertaining and informative introduction to his thinking. They cover all the issues Foucault dealt with, including power, knowledge, subjectivity and sexuality and discuss the development of his analysis (...) throughout his work. (shrink)

A symposium was held at the Centre for Research in the Arts, Social Sciences and Humanities at the University of Cambridge on June 12th 2019, ‘Rethinking Repetition in a Digital Age’, at which Geoff Stead, a leading mobile tech designer, was a keynote speaker. The focus of the Cambridge UK event was on how the potentials of digital technologies—whose harms have received widespread attention—could be redirected for the social good. For Stead, this is precisely what Babbel are doing in (...) their approach to commercial digital language learning. Stead spoke to the idea of reversing our personal relationships to mechanical affordances, and finding empowerment in understanding their designed logics. The transcript of the interview below, made in October 2021, revisits some of the main points he raised at that event. (shrink)

Contextualism in epistemology has traditionally been understood as the view that “know” functions semantically like an indexical term, encoding different contents in contexts with different epistemic standards. But the indexical hypothesis about “know” faces a range of objections. This article explores an alternative version of contextualism on which “know” is a semantically stable term, and the truth-conditional variability in knowledge claims is a matter of pragmatic enrichment. The central idea is that in contexts with stringent epistemic standards, knowledge claims are (...) narrowed: “know” is used in such contexts to make assertions about particularly demanding types of knowledge. The resulting picture captures all of the intuitive data that motivate contextualism while sidestepping the controversial linguistic thesis at its heart. After developing the view, the article shows in detail how it avoids one influential linguistic objection to traditional contextualism concerning indirect speech reports, and then answers an objection concerning the unavailability of certain types of clarification speeches. (shrink)

Discusses the importance of the early history of Greek mathematics to education and civic life through a study of the Parthenon and dialogues of Plato.

Traditional approaches tend to regard figuration (and by extension, deference in general) as an essentially marked or playful use of language, which is associated with a pronounced stylistic effect. For linguistic purposes, however, there is no reason for assigning a special place to deferred uses that are stylistically notable — the sorts of usages that people sometimes qualify with a phrase like "figuratively speaking." There is no important linguistic difference between using redcoat to refer to a British soldier and using (...) suit to refer to a corporate executive (as in "A couple of suits stopped by to talk about the new products"). What creates the stylistic effect of the latter is not the mechanism that generates it, but the marked background assumptions that license it — here, the playful presupposition that.. (shrink)

This paper argues against the view that trolley cases are of little or no relevance to the ethics of automated vehicles. Four arguments for this view are outlined and rejected: the Not Going to Happen Argument, the Moral Difference Argument, the Impossible Deliberation Argument and the Wrong Question Argument. In making clear where these arguments go wrong, a positive account is developed of how trolley cases can inform the ethics of automated vehicles.

The phenomenon of systematic polysemy offers a fruitful domain for examining the theoretical differences between lexicological and lexicographic approaches to description. We consider here the process that provides for systematic conversion of count to mass nouns in English (a chicken Æ chicken, an oak Æ oak etc.). From the point of view of lexicology, we argue, standard syntactic and pragmatic tests suggest the phenomenon should be described by means of a single unindividuated transfer function that does not distinguish between interpretations (...) (rabbit = "meat" vs. "fur"). From the point of view of lexicography, however, these pragmatically determined"sense precisions" are made part of explicit description via the inclusion of semantic "licenses," a mechanism distinct from lexical rules. (shrink)

Even if our justified beliefs are closed under known entailment, there may still be instances of transmission failure. Transmission failure occurs when P entails Q, but a subject cannot acquire a justified belief that Q by deducing it from P. Paradigm cases of transmission failure involve inferences from mundane beliefs (e.g., that the wall in front of you is red) to the denials of skeptical hypotheses relative to those beliefs (e.g., that the wall in front of you is not white (...) and lit by red lights). According to the Bayesian explanation, transmission failure occurs when (i) the subject’s belief that P is based on E, and (ii) P(Q|E) P(Q). No modifications of the Bayesian explanation are capable of accommodating such cases, so the explanation must be rejected as inadequate. Alternative explanations employing simple subjunctive conditionals are fully capable of capturing all of the paradigm cases, as well as those missed by the Bayesian explanation. (shrink)

The Thousands of Problems for Theorem Provers (TPTP) World is a well-established infrastructure that supports research, development and deployment of automated theorem proving systems. This paper provides an overview of the logic languages of the TPTP World, from classical first-order form (FOF), through typed FOF, up to typed higher-order form, and beyond to non-classical forms. The logic languages are described in a non-technical way and are illustrated with examples using the TPTP language.

Karl Popper is a philosopher of knowledge and politics, rationality and freedom. His ideas have won acceptance and provoked controversy among an academic as well as a more general audience. This book aims to broaden our understanding of Popper's philosophy. It is one of the few studies to present his work as an evolving "system of ideas", and to take account of the full range of his writings. The book discusses Popper's early philosophy of politics, science and social science, as (...) well as his later philosophy, which offers an evolutionary account of human nature and the growth of knowledge. Contrary to many earlier interpretations, Stokes argues that we should look to Popper's political values to understand the unity of his work and the evolution of his theory of knowledge and general philosophy. The chapters in this book examine Popper's arguments, and offer critical analysis of the achievements and shortcomings of his philosophy. In particular, Stokes considers the problems of rationality, politics and ethics in the context of debates between the Frankfurt School of critical theory and critical rationalism. The book will be of interest to second-year undergraduates and above in the fields of philosophy and critical theory. (shrink)

Transitional justice scholars are increasingly concerned with measuring the impact of transitional justice initiatives. Scholars often assume that TJ mechanisms must be properly designed and ordered to achieve lasting effect, but the impact of TJ timing and sequencing has attracted relatively little theoretical or empirical attention. Focusing on Latin America, this article explores variation within the region as to when TJ occurs and the order in which mechanisms are implemented. We utilize qualitative comparative analysis to assess the impact of TJ (...) timing and sequencing on democratic development. We find little evidence for path dependency owing to the chronological order of mechanisms. We do find, however, that amnesties and trials approach a sufficient condition for democratic consolidation in Latin America; trials, however, come closest to being a necessary condition for successful democratic consolidation. (shrink)

Whether it seems that you know something depends in part upon practical factors. When the stakes are low, it can seem to you that you know that p, but when the stakes go up it'll seem to you that you don't. The apparent sensitivity of knowledge to stakes presents a serious challenge to epistemologists who endorse a stable semantics for knowledge attributions and reject the idea that whether you know something depends on how much is at stake. After arguing that (...) previous attempts to meet this challenge fall short, I offer a new solution: the unassertability account. The account starts with the observation that high stakes subjects aren't in an epistemic position to assert. We generally presuppose that knowing is sufficient for epistemically proper assertion, but this presupposition only stands up to scrutiny if we draw a distinction between two notions of epistemic propriety, and we shouldn't expect ordinary speakers to draw it. A subject in a high stakes situation who fails to draw the distinction will be led by the sufficiency claim to treat anything she isn't in a position to assert as something she isn't in a position to know. The sensitivity of epistemically proper assertion to practical factors explains the merely apparent sensitivity of knowledge to stakes. (shrink)

Demonstratives and Indexicals In the philosophy of language, an indexical is any expression whose content varies from one context of use to another. The standard list of indexicals includes pronouns such as “I”, “you”, “he”, “she”, “it”, “this”, “that”, plus adverbs such as “now”, “then”, “today”, “yesterday”, “here”, and “actually”. Other candidates include the tenses … Continue reading Demonstratives and Indexicals →.

This article holds that governmental investments in quantum technologies speak to the imaginable futures of digital sovereignty and digital infrastructures, two major areas of change driven by related technologies like AI and Big Data, among other things, in international law today. Under intense development today for future interpolation into digital systems that they may alter, quantum technologies occupy a sort of liminal position, rooted in existing assemblages of computational technologies while pointing to new horizons for them. The possibilities they raise (...) are neither certain nor determinate, but active investments in them (legal, political and material investments) offer perspective on digital technology-driven influences on an international legal imagination. In contributing to visions of the future that are guiding ambitions for digital sovereignty and digital infrastructures, quantum technologies condition digital technology-driven changes to international law and legal imagination in the present. Privileging observation and description, I adapt and utilize a diffractive method with the aim to discern what emerges out of the interference among the several related things assembled for this article, including material technologies and legal institutions. In conclusion, I observe ambivalent changes to an international legal imagination, changes which promise transformation but appear nonetheless to reproduce current distributions of power and resources. (shrink)

Alvin Plantinga has argued that evolutionary naturalism (the idea that God does not tinker with evolution) undermines its own rationality. Natural selection is concerned with survival and reproduction, and false beliefs conjoined with complementary motivational drives could serve the same aims as true beliefs. Thus, argues Plantinga, if we believe we evolved naturally, we should not think our beliefs are, on average, likely to be true, including our beliefs in evolution and naturalism. I argue herein that our cognitive faculties are (...) less reliable than we often take them to be, that it is theism which has difficulty explaining the nature of our cognition, that much of our knowledge is not passed through biological evolution but learned and transferred through culture, and that the unreliability of our cognition helps explain the usefulness of science. (shrink)

The product/process distinction with regards to “argument” has a longstanding history and foundational role in argumentation theory. I shall argue that, regardless of one’s chosen ontology of arguments, arguments are not the product of some process of arguing. Hence, appeal to the distinction is distorting the very organizational foundations of argumentation theory and should be abandoned.

The concept of integration has garnered increased attention in the past few years, despite a long history of only brief mention. Integration services are offered by therapists, coaches, and other practitioners, or may be self-guided. There are many definitions of psychedelic integration, and the term encompasses a range of practices and techniques. This seems to have led to confusion about what integration is and how it is best practiced. The primary focus of this manuscript is the presentation of the first (...) extensive review and concept analysis of definitions, practices, and models of psychedelic integration. We provide a synthesized definition of integration, synthesized model of integration, and comprehensive summary of integration practices to bring clarity to the subject. (shrink)

The use of machine learning systems for decision-support in healthcare may exacerbate health inequalities. However, recent work suggests that algorithms trained on sufficiently diverse datasets could in principle combat health inequalities. One concern about these algorithms is that their performance for patients in traditionally disadvantaged groups exceeds their performance for patients in traditionally advantaged groups. This renders the algorithmic decisions unfair relative to the standard fairness metrics in machine learning. In this paper, we defend the permissible use of affirmative algorithms; (...) that is, algorithms trained on diverse datasets that perform better for traditionally disadvantaged groups. Whilst such algorithmic decisions may be unfair, the fairness of algorithmic decisions is not the appropriate locus of moral evaluation. What matters is the fairness of final decisions, such as diagnoses, resulting from collaboration between clinicians and algorithms. We argue that affirmative algorithms can permissibly be deployed provided the resultant final decisions are fair. (shrink)

Arendt famously pointed out that only citizenship actually confers rights in the modern world. To be a citizen is to be one who has the ‘right to have rights’. Arendt’s analysis emerges out of her recognition that there is a contradiction between this way of conferring rights as tied to the nation-state system and the more philosophical and ethical conceptions of the ‘rights of man’ and notions of ‘human rights’ like those championed by thinkers such as Immanuel Kant who understands (...) rights belonging universally to all humans as a result of facts having to do with what it means to be human. Étienne Balibar, in his recent work, adds to this by pointing out that there is a contradictory movement between this universalizing tendency in philosophical thought and the production of the citizen-subject out of the exclusionary acts of law and force. In this article, I put Balibar’s work in dialogue with the contemporary moment where we are witnessing the re-emergence of a nativist right populism. I use Balibar to help distinguish between three modes of political existence that we find today. Two of these three are more or less well understood. They are the non-citizen, who has no – or almost no – rights in a given nation-state and the citizen who enjoys the full benefit of the rights a given nation-state has to give. The third category is what I term the ‘nominal citizen’. This last category is somewhere in between full citizenship and non-citizenship. Individuals in this last category have rights in name but are largely unable to exercise them. Understanding this last category can, among other things, help us at least partially make sense of the return of right populism and also help us see the ways in which the modern category of citizenship, with its contradictions as elaborated by Balibar, can provide a means for resistance. (shrink)

In his excellent essay, ‘Nudges in a post-truth world’, Neil Levy argues that ‘nudges to reason’, or nudges which aim to make us more receptive to evidence, are morally permissible. A strong argument against the moral permissibility of nudging is that nudges fail to respect the autonomy of the individuals affected by them. Levy argues that nudges to reason do respect individual autonomy, such that the standard autonomy objection fails against nudges to reason. In this paper, I argue that Levy (...) fails to show that nudges to reason respect individual autonomy. (shrink)

This book provides an integrated and philosophically-grounded framework which enables a coherent approach to organizations and organizational ethics from the perspective of practitioners in the workplace, from the perspective of managers in organizations, as well as from the perspective of organizations themselves.

Suppose a driverless car encounters a scenario where harm to at least one person is unavoidable and a choice about how to distribute harms between different persons is required. How should the driverless car be programmed to behave in this situation? I call this the moral design problem. Santoni de Sio defends a legal-philosophical approach to this problem, which aims to bring us to a consensus on the moral design problem despite our disagreements about which moral principles provide the correct (...) account of justified harm. He then articulates an answer to the moral design problem based on the legal doctrine of necessity. In this paper, I argue that Santoni de Sio’s answer to the moral design problem does not achieve the aim of the legal-philosophical approach. This is because his answer relies on moral principles which, at least, utilitarians have reason to reject. I then articulate an alternative reading of the doctrine of necessity, and construct a partial answer to the moral design problem based on this. I argue that utilitarians, contractualists and deontologists can agree on this partial answer, even if they disagree about which moral principles offer the correct account of justified harm. (shrink)

Some expressions of English, like the demonstratives ‘this’ and ‘that’, are referentially promiscuous: distinct free occurrences of them in the same sentence can differ in content relative to the same context. One lesson of referentially promiscuous expressions is that basic logical properties like validity and logical truth obtain or fail to obtain only relative to a context. This approach to logic can be developed in just as rigorous a manner as David Kaplan’s classic logic of demonstratives. The result is a (...) logic that applies to arguments in English containing multiple occurrences of referentially promiscuous expressions. (shrink)

For well over a thousand years, countless audiences have taken pleasure in watching unfold the following fearful event:Filled with dread, desperately tossing unchewed grass from its mouth, looking back at the hunting king, a beautiful deer springs into flight to escape a fast-approaching chariot from which repeated arrows fly — one of which will inevitably lodge in the deer’s defenseless body. This is not a scene from “National Geographic” or an episode from some sadly popular TV hunting show. Indeed, this (...) scene has been played out far longer than any current program on America’s “Outdoor Channel,” and it comes to most Westerners from half a world away. Kālidāsa’s The Signet-Ring of Śakuntalā, the most famous poem.. (shrink)

This paper presents a discussion of my personal experiences of selling a family farm and analyses those experiences using the layered account form of autoethnographic writing. I describe how the cultural influences from family farming led me, a farmer’s son, to also become a farmer, why farmers may choose to continue in their occupation sometimes against increasingly negative economic pressures, why I continued farming for as long as I did, and the thoughts and feelings associated with my decision to sell (...) my farm and exit the industry. I discuss the emotions that I experienced and place them in a theoretical context that makes them more understandable to others. Because this paper examines the effects from my decision to retire from farming it makes a contribution to the limited literature on farmers’ retirement. (shrink)

Patrick O'Brian, the Aubrey-Maturin Series of twenty novels (Norton, 1970-1999). My appreciation written for WIRED magazine: "I re-read this extraordinary series of novels because of the depth of portrayal of the major and minor characters, but also because they teach me so much about what science and technology were like two centuries ago. O'Brian shows you the world-that-was through the eyes of a Tory naval captain (Jack Aubrey), at sea since the age of 12, working his way up to admiral, (...) dealing with the height of 18th-century technology (sailing ships and celestial navigation). I identify more strongly with his liberally-educated, physician-scientist friend (Stephen Maturin), who went to medical school in Paris during the French Revolution. You see natural history turning into a biological science, bleeding-and-purging medicine starting to learn some physiology -- and, because Maturin is also an intelligence agent for the Admiralty, you see statecraft at work during the Napoleonic Wars. These books strongly remind you about what scientific ignorance and social conventions can do to your mindset, and how the future will likely judge us as well." -- William H. Calvin You can get them all at once, so you can: The Complete Aubrey/Maturin Series (20 volumes). Depending on amazon.com's current discount, this works out to US$15-20 each (and in hardcover). (shrink)

Allshorn, Geoff I believe the year in which I was born to be a very important year, perhaps not surprisingly, but particularly because of other events which would ultimately become significant in my own life.

In an earlier defense of the view that the fundamental logical properties of logical truth and logical consequence obtain or fail to obtain only relative to contexts, I focused on a variation of Kaplan’s own modal logic of indexicals. In this paper, I state a semantics and sketch a system of proof for a first-order logic of demonstratives, and sketch proofs of soundness and completeness. (I omit details for readability.) That these results obtain for the first-order logic of demonstratives shows (...) that the significance of demonstratives for logic exceeds their behavior as rigid designators in counterfactual reasoning, or reasoning about alternative possibilities. Furthermore, the results in this paper help address one common objection to the view that logical truth and consequence obtain only relative to contexts. According to this objection, the view entails that logical consequence is not formal. (shrink)

Collective intelligence is much talked about but remains very underdeveloped as a field. There are small pockets in computer science and psychology and fragments in other fields, ranging from economics to biology. New networks and social media also provide a rich source of emerging evidence. However, there are surprisingly few useable theories, and many of the fashionable claims have not stood up to scrutiny. The field of analysis should be how intelligence is organised at large scale—in organisations, cities, nations and (...) networks. The paper sets out some of the potential theoretical building blocks, suggests an experimental and research agenda, shows how it could be analysed within an organisation or business sector and points to the possible intellectual barriers to progress. (shrink)

The paper begins by exploring whether a “tendency to avarice” exists in most capitalist business organisations. It concludes that it does and that this is problematic. The problem centres on the potential threat to the integrity of human character and the disablement of community.What, then, can be done about it? Building on previous work (Moore, 2002) in which MacIntyre’s notions of practice and institution were explored (MacIntyre, 1985), the paper offers a philosophically based argument in favour of the rediscovery of (...) craftsmanship by those who work in business organisations, and the exercise of craftsmanship in community.The practical implications for individuals of this way of conceptualising business, and the virtues which must then come to the fore, are discussed. (shrink)

Suppose that an autonomous vehicle encounters a situation where imposing a risk of harm on at least one person is unavoidable; and a choice about how to allocate risks of harm between different persons is required. What does morality require in these cases? Derek Leben defends a Rawlsian answer to this question. I argue that we have reason to reject Leben’s answer.

Engineering failure investigations seek to reconstruct the actual causes of major engineering failures. The investigators need to establish the existence of certain past events and the actual causal relationships that these events bear to the failures in question. In this paper, I examine one method for reconstructing the actual causes of failure events, which I call "feature dependence". The basic idea of feature dependence is that some features of an event are informative about the features of its causes; therefore, the (...) investigators can use the features of a known failure event to reconstruct details of its causes. I make explicit the structure of feature dependence and the evidential basis of its key premises, and show how feature dependence works in the investigation of the American Airlines Flight 191 accident. (shrink)

1. Introduction Geoff Cockfield, Ann Firth and John Laurent -/- 2. The Role of Thumos in Adam Smith’s System Lisa Hill -/- 3. Adam Smith’s Treatment of the Greeks in The Theory of Moral Sentiments: The Case of Aristotle Richard Temple-Smith -/- 4. Adam Smith, Religion and the Scottish Enlightenment Pete Clarke -/- 5. The ‘New View’ of Adam Smith and the Development of his Views Over Time James E. Alvey -/- 6. The Moon Before the Dawn: A Seventeenth-Century (...) Precursor of Smith’s The Theory of Moral Sentiments Jack Barbalet -/- 7. Adam Smith’s Moral Philosophy as Ethical Self-formation Ann Firth -/- 8. Science and its Applications in The Theory of Moral Sentiments David Thorpe -/- 9. Adam Smith, Charles Darwin and the Moral Sense John Laurent and Geoff Cockfield. (shrink)