When we are fatigued, we feel that our performance is worse than when we are fresh. Yet, for over 100 years, researchers have been unable to identify an objective, behavioral measure that covaries with the subjective experience of fatigue. Previous work suggests that the metrics of signal detection theory —response bias and perceptual certainty —may change as a function of fatigue, but no work has yet been done to examine whether these metrics covary with fatigue. Here, we investigated cognitive fatigue (...) using SDT. We induced fatigue through repetitive performance of the n-back working memory task, while functional magnetic resonance imaging data was acquired. We also assessed cognitive fatigue at intervals throughout. This enabled us to assess not only whether criterion and d’ covary with cognitive fatigue but also whether similar patterns of brain activation underlie cognitive fatigue and SDT measures. Our results show that both criterion and d’ were correlated with changes in cognitive fatigue: as fatigue increased, subjects became more conservative in their response bias and their perceptual certainty declined. Furthermore, activation in the striatum of the basal ganglia was also related to cognitive fatigue, criterion, and d’. These results suggest that SDT measures represent an objective measure of cognitive fatigue. Additionally, the overlap and difference in the fMRI results between cognitive fatigue and SDT measures indicate that these measures are related while also separate. In sum, we show the relevance of SDT measures in the understanding of fatigue, thus providing researchers with a new set of tools with which to better understand the nature and consequences of cognitive fatigue. (shrink)

Throughout the animal kingdom, p53 genes function to restrain mobile elements and recent observations indicate that transposons become derepressed in human cancers. Together, these emerging lines of evidence suggest that cancers driven by p53 mutations could represent “transpospoathies,” i.e. disease states linked to eruptions of mobile elements. The transposopathy hypothesis predicts that p53 acts through conserved mechanisms to contain transposon movement, and in this way, prevents tumor formation. How transposon eruptions provoke neoplasias is not well understood but, from a broader (...) perspective, this hypothesis also provides an attractive framework to explore unrestrained mobile elements as inciters of late‐onset idiopathic disease.Also see the video abstract here. (shrink)

Abstract:There is an established narrative in which the world shrinks, distances are overcome and rendered insignificant, and the near and the far lose their salience as means of orientation and understanding. Yet, within this narrative, new distances are equally felt and observed to have opened up. New distances between and amongst us, multiplying distances of indifference, incomprehension and antagonism. And felt distances also between ourselves and ‘land’ and ‘nature’—a sense of separation, alienation and loss which it then becomes imperative, ethically (...) and environmentally, to overcome.In this general context, this article asks: is it possible to sense distance more positively? Given the scope of the topic, the article aims primarily to offer key frameworks and avenues for rethinking distance. In two initial sections I consider distance in terms of ethics and spatialities respectively. Then, in a lengthier third and final discussion, I turn to landscape specifically as a venue for thinking distance anew. Notions of apartness and alienation are, it can be argued, historically stitched into Western visual art traditions of landscape. In Robin Kelsey's terms, landscape names a “fantasy of not belonging to the totality of life of a terrestrial expanse.” But, drawing in particular upon Jean-Luc Nancy's account of landscape as uncanny and estranged spatiality, I will argue that the distances of not-belonging are actually the signature elements of landscape's distinction as a mode of experience, imagination and presentation. (shrink)

Two fundamental rules of reasoning are Universal Generalisation and Existential Instantiation. Applications of these rules involve stipulations such as ‘Let n be an arbitrary number’ or ‘Let John be an arbitrary Frenchman’. Yet the semantics underlying such stipulations are far from clear. What, for example, does ‘n’ refer to following the stipulation that n be an arbitrary number? In this paper, we argue that ‘n’ refers to a number—an ordinary, particular number such as 58 or 2,345,043. Which one? We (...) do not and cannot know, because the reference of ‘n’ is fixed arbitrarily. Underlying this proposal is a more general thesis: Arbitrary Reference : It is possible to fix the reference of an expression arbitrarily. When we do so, the expression receives its ordinary kind of semantic-value, though we do not and cannot know which value in particular it receives. Our aim in this paper is defend AR. In particular, we argue that AR can be used to provide an account of instantial reasoning, and we suggest that AR can also figure in offering new solutions to a range of difficult philosophical puzzles. (shrink)

My main aim is to clarify what we mean by ‘look’ sentences such as (1) below – ones that we use to talk about visual experience: -/- (1) The ball looked red to Sue -/- This is to help better understand a part of natural language that has so far resisted treatment, and also to help better understand the nature of visual experience. -/- By appealing to general linguistic principles I argue for the following account. First, we use (1) to (...) talk about an event. Second, we use the verb ‘look’ to specify the kind of event about which we are talking – it is a looking event. Third, we use the subject ‘the ball’ to specify a stimulus of the event – something that looks some way in the event. Fourth, we use the adjunct ‘to Sue’ to specify an experiencer of the event – someone to whom things look some way in the event. Finally, we use the complement ‘red’ to specify a way of the event – a way in which the event occurs (I take ways of occurring to be properties of events). Which way do we use ‘red’ in (1) to specify? I argue: the maximally specific way w such that the following is generically true: looking events whose stimulus is red occur in way w (it is important that this is understood generically: this is what does much of the work in explaining our use of (1) and other ‘look’ sentences). Putting this together, what we mean by (1) is: there was a looking event whose stimulus was the ball, whose experiencer was Sue, and which occurred in the maximally specific way that looking events occur when their stimulus is red. -/- This account of how we use ‘red’ in (1) is one of the most interesting aspects of my thesis. It extends to an account of how we use ‘proud’ in ‘John walks proud’, ‘as if he is American’ in ‘John talks as if he is American’, ‘like a duck’ in ‘John sounds like a duck’, and so on. In each case we use the expression in question to specify a way: the maximally specific way proud people walk, the maximally specific way American people talk, and so on. So the study of ‘look’ sentences has much to tell us about the functioning of many other English language constructions, and suggests that ways have a significant role to play in the semantics of natural language – a fact that has not yet been sufficiently recognised by linguists or philosophers of language. -/- My thesis also has implications for the philosophy of perception. One of the central questions about perception is: What is the nature of visual experience? What is it, for example, for a ball to look red to Sue? My thesis offers an answer: What it is for the ball to look red to Sue is for whatever it is that we mean by ‘The ball looks red to Sue’ to be the case, and what we mean by ‘The ball looks red to Sue’ is that there is a looking event whose stimulus is the ball, whose experiencer is Sue, and which is occurring in a certain way. It thus delivers an adverbial account of visual experience, one that has the resources to better deal with problems that are traditionally thought to be decisive against adverbial accounts. (shrink)

The contributions to Testing Scientific Theories are unified by an in-terest in responding to criticisms directed by Glymour against existing models of confirmation—chiefly H-D and Bayesian schemas—and in assessing and correcting the "bootstrap" model of confirmation that he proposed as an alternative in Theory and Evidence (1980). As such, they provide a representative sample of objections to Glymour's model and of the wide range of new initiatives in thinking about scientific confirmation that it has influenced. The effect is a sense (...) of engagement and focus, and of significant advance at least in articulation of the problems that require solution; as Earman observes, "it is . . . heartening to report that the various opposing camps learned from each other" (p. vi).' In what follows I am concerned to assess what has been learned both critically, about Glymour's model, and constructively about the resources of the alternatives he challenges. My thesis is that while the theories emerging in this debate do deal with a wider range of scientific practice than before, their remaining limitations raise important questions about the ambitions and criteria of adequacy that have traditionally governed philosophical inquiry in this area. (shrink)

The contributions to Testing Scientific Theories are unified by an interest in responding to criticisms directed by Glymour against existing models of confirmation–-chiefly H-D and Bayesian schemas–-and in assessing and correcting the “bootstrap“ model of confirmation that he proposed as an alternative in Theory and Evidence. As such, they provide a representative sample of objections to Glymour's model and of the wide range of new initiatives in thinking about scientific confirmation that it has influenced. The effect is a sense of (...) engagement and focus, and of significant advance at least in articulation of the problems that require solution; as Earman observes, “it is … heartening to report that the various opposing camps learned from each other”. In what follows I am concerned to assess what has been learned both critically, about Glymour's model, and constructively about the resources of the alternatives he challenges. My thesis is that while the theories emerging in this debate do deal with a wider range of scientific practice than before, their remaining limitations raise important questions about the ambitions and criteria of adequacy that have traditionally governed philosophical inquiry in this area. (shrink)

The esteemed psychologist and thinker John Dewey headed for previously unexplored philosophical territory with this influential work. Written shortly after World War I, it embodies Dewey's system of pragmatic humanism and maintains that individuals can attain "a more ordered and intelligent happiness" by reconsidering the ultimate effects of their deepest beliefs and feelings. With its promise of achieving an understanding of the past and attaining a brighter future, Reconstruction in Philosophy remains ever relevant. "A modern classic." — Philosophy and (...) Phenomenological Research. (shrink)

Standpoint theory is based on the insight that those who are marginalized or oppressed have distinctive epistemic resources with which to understand social structures. Inasmuch as these structures shape our understanding of the natural and lifeworlds, standpoint theorists extend this principle to a range of biological and physical as well as social sciences. Standpoint theory has been articulated as a social epistemology and as an aligned methodological stance. It provides the rationale for ‘starting research from the margins’ and for expanding (...) the diversity of backgrounds and experience represented in scientific communities. (shrink)

Ethicists and social scientists alike have advocated for the inclusion of vulnerable populations in research and decision-making on climate engineering. Unfortunately, there have been few efforts to do so. The research presented in this paper was designed to build knowledge about how vulnerable populations think about climate engineering. The goal of this manuscript is to bring the ethics literature on climate engineering into dialogue with emerging social science data documenting the perspectives of vulnerable populations. The results indicate some concerns among (...) vulnerable populations may resemble those outlined by ethicists. However, the perspectives expressed by interviewees also extend previous ethical treatments by indicating ways in which climate engineering could compound existing injustices. (shrink)

Standpoint theory is an explicitly political as well as social epistemology. It’s distinctive features are commitment to understand the social locations that shape the epistemic capacities and resources of individuals in structural terms, and a recognition that those who are marginalized within hierarchically structured systems of social differentiation are often epistemically advantaged. In some crucial domains they know more and know better as a contingent function of their situated experience and knowledge. This “inversion thesis” counters the alignment of social with (...) epistemic privilege. (shrink)

Material traces of the past are notoriously inscrutable; they rarely speak with one voice, and what they say is never unmediated. They stand as evidence only given a rich scaffolding of interpretation which is, itself, always open to challenge and revision. And yet archaeological evidence has dramatically expanded what we know of the cultural past, sometimes demonstrating a striking capacity to disrupt settled assumptions. The questions we address in Evidential Reasoning are: How are these successes realized? What gives us confidence (...) in the credibility and robustness, the trustworthiness, of the evidential claims based on archaeological data? And, what constitute best practices in building evidential claims, critically scrutinizing them and putting them to work in archaeological contexts? Rather than retreat to abstractions about how how science operates in the ideal, we approach this question by interrogating a number of close-to-the-ground case studies with the aim of teasing out the wisdom embodied in archaeological practice. The cases we consider – of fieldwork, strategies for working with old evidence, and the role of external resources – illuminate the role of various types of inferential scaffolding and bring into focus practice-grounded epistemic norms that we believe serve archaeologists better than the all-or-nothing ideals of truth and objectivity that dominate programmatic debate. (shrink)

Neither the range of potential results from genomic research that might be returned to participants nor future uses of stored data and biospecimens can be fully predicted at the outset of a study. Informed consent procedures require clear explanations about how and by whom decisions are made and what principles and criteria apply. To ensure trustworthy research governance, there is also a need for empirical studies incorporating public input to evaluate and strengthen these processes.

I develop a theory of what we mean by the 'look' sentences that we use to describe our visual experiences, and on that basis develop a new adverbial theory of what it is to have a visual experience with a certain character.

With precision and profundity born of 30 years of devoted study, John Boyle offers an essential introduction to St. Thomas Aquinas on Scripture, shedding helpful light on the goals, methods, and commitments that animate the Angelic Doctor's engagement with the sacred page. Because the genius of St. Thomas's approach to the Bible lies not so much in its novelty but rather in the fidelity and clarity with which he recapitulates the riches of the preceding interpretive Tradition, this initiation into (...) St. Thomas's vision of Scripture is itself an orientation to the Church's vision of Scripture, from the Fathers through and beyond the Middle Ages. St. Thomas's embeddedness within the Church's Tradition and his own historical context is integral to his approach to Scripture, yet it sets him at some distance from modern readers, for whom his interpretive vision may seem perplexing or even impenetrable. In this Primer, Boyle first provides an acclimation to this medieval context through a survey and explanation of pertinent technical terminology used by St. Thomas and characteristic of the scholastic theology of the time. With an eye to the medieval practice of considering Scripture according to the fourfold division of causes, Boyle builds on this initial foundation by exploring in turn St. Thomas's accounts of the end or use of Scripture (final cause), its divine and human authorship (efficient cause), its order and division (material cause), and its literary styles or genres (formal cause). Drawing on writings from across St. Thomas's corpus, but especially his work On the Commendation and Division of Sacred Scripture and the prologues to his biblical commentaries, Boyle masterfully elucidates both the hermeneutical principles and deep wisdom of the Angelic Doctor's approach to Scripture, imparting invaluable guidance not only for reading and understanding St. Thomas and other great masters of the Tradition, but also-and ultimately-for understanding Scripture in light of this Tradition and reading it with greater benefit and joy. (shrink)

Solidarity means standing with others: expressing support in times of stress and working together toward shared goals. As Saunkeah and colleagues note, solidarity also incorp...

Despite recurring efforts, a gap exists across a variety of contexts between the protection of patients' safety in theory and in practice. This timely Research Handbook highlights these critical issues and suggests both legal and policy changes are necessary to better protect patients' safety. Multidisciplinary in nature, this Research Handbook features contributions from eminent academics, policy makers and medical practitioners from the Global North and South, discussing the essential facets concerning patient safety and the law. It highlights how the role (...) of legislation and case law has the potential to influence, both positively and negatively, medical practice and the quality of care. Chapters explore patient safety and the global health agenda; physiotherapy; 'non-therapeutic' clinical research with children; patient safety awareness in healthcare education; and the increasing use of robotics and artificial intelligence in healthcare. Outlining a wide range of international perspectives on patient safety and the law, this Research Handbook will appeal to academics and researchers specialising in health and medical law, human rights and healthcare regulation. It will also serve as a valuable resource for legal and medical practitioners alike, as well as clinicians and professionals working in healthcare governance. (shrink)

Common sense and philosophical tradition agree that mind makes a difference. What we do depends not only on how our bodies are put together, but also on what we think. Explaining how mind can make a difference has proved challenging, however. Some have urged that the project faces an insurmountable dilemma: either we concede that mentalistic explanations of behavior have only a pragmatic standing or we abandon our conception of the physical domain as causally autonomous. Although each option has its (...) advocates, most theorists have sought a middle way that accommodates both the common-sense view of mind and the metaphysical conviction about the physical world. This volume presents a collection of new, specially written essays by a diverse group of philosophers, each of whom is widely known for defending a particular conception of minds and their place in nature. Contributors include Robert Audi, Lynne Rudder Baker, Tyler Burge, Donald Davidson, Fred Dretske, Ted Honderich, Jennifer Hornsby, Frank Jackson, Jaegwon Kim, Brian P. McLaughlin, Ruth Garrett Millikan, H. W. Noonan, Philip Pettit, Ernest Sosa, and Robert Van Gulick. (shrink)

Michael Smith attempts to solve the moral problem by arguing that our moral beliefs constitute a rational constraint on our desires. In particular, Smith defends the ‘practicality requirement’, which says that rational agents who believe that an action is right must have some desire to perform that action. We clarify and examine Smith’s argument. We argue that, for the argument to be sound, it must make two crucial assumptions about the rational agent in question: that facts about her desires are (...) transparent to her, and that she believes that she is rational. We conclude that if Smith has solved the moral problem then he has done so only for a restricted class of subjects—those who satisfy these two assumptions. (shrink)

The notion of proof is central to mathematics yet it is one of the most difficult aspects of the subject to teach and master. In particular, undergraduate mathematics students often experience difficulties in understanding and constructing proofs. Understanding Mathematical Proof describes the nature of mathematical proof, explores the various techniques that mathematicians adopt to prove their results, and offers advice and strategies for constructing proofs. It will improve students’ ability to understand proofs and construct correct proofs of their own. The (...) first chapter of the text introduces the kind of reasoning that mathematicians use when writing their proofs and gives some example proofs to set the scene. The book then describes basic logic to enable an understanding of the structure of both individual mathematical statements and whole mathematical proofs. It also explains the notions of sets and functions and dissects several proofs with a view to exposing some of the underlying features common to most mathematical proofs. The remainder of the book delves further into different types of proof, including direct proof, proof using contrapositive, proof by contradiction, and mathematical induction. The authors also discuss existence and uniqueness proofs and the role of counter examples. (shrink)

In this philosophically sophisticated and historically significant work, John H. Zammito reconstructs Kant's composition of The Critique of Judgment and reveals that it underwent three major transformations before publication. He shows that Kant not only made his "cognitive" turn, expanding the project from a "Critique of Taste" to a Critique of Judgment but he also made an "ethical" turn. This "ethical" turn was provoked by controversies in German philosophical and religious culture, in particular the writings of Johann Herder and (...) the Sturm und Drang movement in art and science, as well as the related pantheism controversy. Such topicality made the Third Critique pivotal in creating a "Kantian" movement in the 1790s, leading directly to German Idealism and Romanticism. The austerity and grandeur of Kant's philosophical writings sometimes make it hard to recognize them as the products of a historical individual situated in the particular constellation of his time and society. Here Kant emerges as a concrete historical figure struggling to preserve the achievements of cosmopolitan Aufkl-rung against challenges in natural science, religion, and politics in the late 1780s. More specifically Zammito suggests that Kant's Third Critique was animated throughout by a fierce personal rivalry with Herder and by a strong commitment to traditional Christian ideas of God and human moral freedom. "A work of extraordinary erudition. Zammito's study is both comprehensive and novel, connecting Kant's work with the aesthetic and religious controversies of the late eighteenth century. He seems to have read everything. I know of no comparable historical study of Kant's Third Critique."-Arnulf Zweig, translator and editor of Kant's ;IPhilosophical Correspondence, 1759-1799;X "An intricate, subtle, and exciting explanation of how Kant's thinking developed and adjusted to new challenges over the decade from the first edition of the Critique of Pure Reason to the appearance of the Critique of Judgment. "--John W. Burbidge, Review of Metaphysics "There has been for a long time a serious gap in English commentary on Kant's Critique of Judgment Zammito's book finally fills it. All students and scholars of Kant will want to consult it."--Frederick Beiser, Times Literary Supplement. (shrink)

In books such as The World Within the World and The Anthropic Cosmological Principle, astronomer John Barrow has emerged as a leading writer on our efforts to understand the universe. Timothy Ferris, writing in The Times Literary Supplement of London, described him as "a temperate and accomplished humanist, scientist, and philosopher of science--a man out to make a contribution, not a show." Now Barrow offers the general reader another fascinating look at modern physics, as he explores the quest for (...) a single, unifying theory that will unlock nature's secrets. Theories of Everything is more than a history of science, more than a popular report on recent research and discoveries. Barrow provides a reflective, intelligent commentary on what a true Theory of Everything would be--its ingredients, its limitations, and what it could tell us about the universe. Never before, he writes, have physicists been so confident and so eager in the hunt for this "cosmic Rosetta Stone," as he calls it: "a single all-embracing picture of all the laws of nature from which the inevitability of all things seen must follow with unimpeachable logic." He lays out eight essential ingredients for a Theory of Everything and then explores each in turn, tracing how our knowledge has developed and how scientific discovery relates to our changing philosophy and religious thought in each area. Some of these ingredients are obvious--the laws of nature must be explained, for example, as well as its organizing principles--but others may be surprising, such as broken symmetries and selection biases. A Theory of Everything must account for the fact that the universe is "messy and complicated," he tells us, and for the limitations imposed by the questions we ask and the information we can obtain. The key lies in the remarkable capacity of mathematics to express the fundamental workings of the physical world--a language that the human mind is uniquely equipped to understand and manipulate. Barrow examines what mathematics actually is and describes how it makes the universe intelligible and provides a path to the underlying coherence in nature--which has led, in fact, to arguments that the universe itself is a vast computer. Yet even the most complete theory, even the most comprehensive mathematical explanation, cannot account for the uncomputable varieties of human experience and thought. "No non-poetic account of reality," he writes, "can be complete." In a field where the authorities converse in equations and mathematical notations, John Barrow speaks with the voice of thoughtful and knowledgeable humanist. Written with eloquence and expertise, Theories of Everything establishes a new perspective on humanity's efforts to explain the universe. (shrink)

The British bestseller Straw Dogs is an exciting, radical work of philosophy, which sets out to challenge our most cherished assumptions about what it means to be human. From Plato to Christianity, from the Enlightenment to Nietzsche and Marx, the Western tradition has been based on arrogant and erroneous beliefs about human beings and their place in the world. Philosophies such as liberalism and Marxism think of humankind as a species whose destiny is to transcend natural limits and conquer the (...) Earth. John Gray argues that this belief in human difference is a dangerous illusion and explores how the world and human life look once humanism has been finally abandoned. The result is an exhilarating, sometimes disturbing book that leads the reader to question our deepest-held beliefs. Will Self, in the New Statesman , called Straw Dogs his book of the year: “I read it once, I read it twice and took notes . . . I thought it that good.” “Nothing will get you thinking as much as this brilliant book” ( Sunday Telegraph ). (shrink)

This is the second volume of Professor Macmurray's Gifford Lectures on The Form of the Personal. The first volume, The Self as Agent, was concerned to shift the center of philosophy from thought to action. Persons in Relation, starting from this practical standpoint, sets out to show that the form of personal life is determined by the mutuality of personal relationship, so that the unit of human life is not the "I" alone, by the "You and I.".

Will we ever discover a single scientific theory that explains everything that has ever happened and everything that will happen - a key that unlocks the ...

Existential instantiation is a rule of inference that allows us infer, from the proposition that there are some p things, the proposition that a is a p thing. What role does 'a' play here? According to one account, recently defended by Breckenridge and Magidor, we use 'a' to refer to a p thing. I argue that this cannot be right. I propose an alternative account, according to which we use 'a' to refer to a supposedly p thing.

There is an account of modal operators that is both elegant and powerful and that deserves to be called the standard account. There are, however, some epistemic uses of modal operators which seem to be counterexamples to the account – they pose what I call the objectivity problem. It is often thought that the objectivity problem can be fixed by a certain kind of modification to the standard account. I argue that this kind of modification cannot work. Then I argue (...) that the problem posed for the standard account by recently discussed eavesdropper cases is really just the objectivity problem in a different guise, thereby emphasizing the need for a new solution to the objectivity problem. Finally, I propose a new solution to the objectivity problem. (shrink)

Among the most characteristic effects of the onset of "romanticism" in the eighteenth century was the underinining of the "classical" ethics, based on rational selfdiscipline, by the "romantic" or humanitarian ethics, based on benevolism. A useful indication of the point at which this change in ethics occurred is the moment in which the institution of Negro slavery was attacked by benevolistic theory. As Trevelyan says, the anti-slavery movement was "the first successful propagandist agitation of the modern type" ; years before (...) the eighteenth century there had been sporadic objection against Negro slavery, especially religious objection because Negro slaves were commonly not considered "children of God." But until Francis Hutcheson's System of Moral Philosophy , no writer formulated ethical principles inimical to slavery as an institution. (shrink)