Gene discovery reveals new biology, expands the utility of marker‐assisted selection, and enables targeted mutagenesis. Still, such discoveries can take over a decade. We present a general strategy, “Agile Genetics,” that uses nested, structured populations to overcome common limits on gene resolution. Extensive simulation work on realistic genetic architectures shows that, at population sizes of >5000 samples, single gene‐resolution can be achieved using bulk segregant pools. At this scale, read depth and technical replication become major drivers of resolution. Emerging enrichment (...) methods to address coverage are on the horizon; we describe one possibility – iterative depth sequencing (ID‐seq). In addition, graph‐based pangenomics in experimental populations will continue to maximize accuracy and improve interpretation. Based on this merger of agronomic scale with molecular and bioinformatic innovation, we predict a new age of rapid gene discovery. (shrink)

Longing is a universal human experience, born of the inevitable gulf between dream and reality, what we need and what we have. While the experience of longing may arise from loss or the awareness of a void in one’s life, it may also become a powerful engine of spiritual growth, prompting one to draw closer to the hidden yet present “Other.” Across the range of Jewish teachings, longing takes center stage in one’s spiritual life. From the Bible through current frontiers (...) in Jewish belief and practice, God is both known and unknown, immediate and remote, present and in constant eclipse. This book captures the sense of longing in Jewish tradition by creating a dialogue between the author’s own struggles with an estranged father and a wide range of traditional and contemporary sources. Focusing on the story of the Hebrew prophet Elisha, the book takes the reader through a journey of abandonment, creative destruction, and ultimately repair and healing, engaging with currents in biblical theology, rabbinic thought, Kabbalah, and contemporary Jewish philosophy. Written in a familiar yet probing style, this book is an accessible introduction to Jewish thought and spirituality as well as a thoughtful companion for more experienced students. (shrink)

In previous work, we presented evidence suggesting that ordinary people do not conceive of subjective experiences as having phenomenal qualities. We then argued that these findings undermine a common justification given for the reality of the hard problem of consciousness. In a thought-provoking article, Talbot has challenged our argument. In this article, we respond to his criticism.

Perhaps the most fundamental disagreement concerning Nietzsche's view of metaphysics is that some commentators believe Nietzsche has a positive, systematic metaphysical project, and others deny this. Those who deny it hold that Nietzsche believes metaphysics has a special problem, that is, a distinctively problematic feature that distinguishes metaphysics from other areas of philosophy. In this paper, I investigate important features of Nietzsche's metametaphysics in order to argue that Nietzsche does not, in fact, think metaphysics has a special problem. The result (...) is that, against a long-standing view held in the literature, we should be reading Nietzsche as a metaphysician. (shrink)

For some, biology explains all there is to know about the mind. Yet many big questions remain: is the mind shaped by genes or the environment? If mental traits are the result of adaptations built up over thousands of years, as evolutionary psychologists claim, how can such claims be tested? If the mind is a machine, as biologists argue, how does it allow for something as complex as human consciousness? The Biological Mind: A Philosophical Introduction explores these questions and more, (...) using the philosophy of biology to introduce and assess the nature of the mind. Drawing on the four key themes of evolutionary biology; molecular biology and genetics; neuroscience; and biomedicine and psychiatry Justin Garson addresses the following key topics: moral psychology, altruism and levels of selection evolutionary psychology and modularity genes, environment and the nature-nurture debate neuroscience, reductionism and the relation between biology and free will function, selection and mental representation psychiatric classification and the maladapted mind. Extensive use of examples and case studies is made throughout the book, and additional features such as chapter summaries, annotated further reading and a glossary make this an indispensable introduction to those teaching philosophy of mind and philosophy of psychology. It will also be an excellent resource for those in related fields such as biology. (shrink)

Nietzsche’s presentation of the eternal recurrence in Gay Science 341 is often viewed as a practical thought experiment meant to radically transform us. But exactly why and how we are supposed to be transformed is not clear. I contend that addressing these issues requires taking a close look at the psychological setting of the passage. The eternal recurrence is presented in our “loneliest loneliness.” I argue that facing the eternal recurrence from a state of profound loneliness both motivates self-transformation and (...) contributes toward helping us succeed at that project. (shrink)

Quantitative assessments of when infectious disease outbreaks end are crucial, as resources targeted towards outbreak responses typically remain in place until outbreaks are declared over. Recent improvements and innovations in mathematical approaches for determining when outbreaks end provide public health authorities with more confidence when making end-of-outbreak declarations. Although quantitative analyses of outbreaks have a long history, more complex mathematical and statistical methodologies for analysing outbreak data were developed early in the 20th century and continue to be refined. Historically, such (...) methodologies focused primarily on factors affecting the early and middle phases of an outbreak, with less attention given to determining how and when outbreaks end. This review discusses mathematical modelling methods from the last 20 years that have been developed for determining the ends of infectious disease outbreaks, and considers factors that affect the accuracy of such determinations. When disease surveillance systems provide timely and representative data to inform models, the timings of end-of-outbreak declarations can be fine-tuned to allow outbreaks to be declared over quickly and with a low risk of being incorrect. Premature declarations that outbreaks are over can undermine earlier achievements in disease control and may result in a resurgence of cases, but unnecessary delays in declaring outbreaks over can cause significant economic and social harm. Appropriate declarations that balance the benefits of relaxing control measures against the risk of a surge in cases allow public health resources to be conserved (and economic and social pressures to be reduced) while limiting the potential for additional transmission. (shrink)

With the expansion of multinational corporations, the alarming upsurge in widely publicized and notable corporate scandals involving MNCs in emerging markets has begun to draw both academic and managerial attention to look beyond home market practices to the pressing concern of CSR in emerging markets. Previous studies on CSR have focused primarily on Western markets, reserving limited discussions in addressing the issue of MNC attitudes and CSR practices in their emerging host markets abroad. Despite this incongruity in academic response to (...) CSR in emerging markets, managers of multinational companies continue to face mounting and most often conflicting pressures to weigh among multiple strategic CSR responses in emerging markets. Such a task is often further complicated by the complexity of varying business norms and standards, regulatory environments, and stakeholder demands for CSR across national boundaries. With such a challenge in mind, I attempt to examine the explanatory factors in leading MNCs, otherwise recognized for accountability and integrity in their home markets, to employ inconsistent or negligent practices under CSR pressure in Chinese emerging economy. Preliminary findings reveal that discrepancies exist in how MNCs perform in CSR in home countries versus in host countries. While MNCs do have much to improve, the institutional environment in the emerging market, including the legal framework and the ethical culture, also needs to be improved by the host country governments, the industry associations, and local firms. Meanwhile, media interest and journalists, NGOs, third party monitors, industry stakeholders as well as consumer advocacy groups can raise the visibility of MNC’s contradictory practices between their origin nations and countries with emerging economies and offer the pressures and incentives for MNCs to amend their ethical shortcomings. This article also suggests implications for both theory and practice. (shrink)

Fictionalism plays a significant role in philosophy today, with defenses spanning mathematics, morality, ordinary objects, truth, modality, and more.1 Fictionalism in the philosophy of science is also gaining attention, due in particular to the revival of Hans Vaihinger’s work from the early twentieth century and to heightened interest in idealization in scientific practice.2 Vaihinger maintains that there is a ubiquity of fictions in science and, among other things, argues that Nietzsche supports the position. Yet, while contemporary commentators have focused on (...) fictionalism in Nietzsche’s moral philosophy, his view of fictions in science has remained largely unexamined.3 In this article, I begin... (shrink)

This book defends the controversial view that Nietzsche is a metaphysician against a tendency to sever Nietzsche from metaphysical philosophy. It shows that for Nietzsche the questions, answers, methods, and subject matters of metaphysics are not only perfectly legitimate, but also crucial for understanding the world and our place within it.

This paper draws upon a research study of accountants and HR specialists. The study eschewed hypothetical scenarios and focused upon those situations and scenarios that the interviewees defined as causing them ethical concerns. There are two distinct but related issues arising from the paper. The first is that the singular categorisations of moral reasoning attributed to individuals when faced with hypothetical scenarios by many who write on the issue of moral reasoning, did not correspond to the fluidity in moral choices (...) faced by the interviewees as they experienced their unfolding moral dilemmas. The second issue relates to the unwillingness of the interviewees to give voice to their concerns, not only externally, but also within their employing organisations. The tensions within the two cases featured were held in check only by the diminution of the autonomy of the two principal actors. As a consequence, the exercise of moral agency was denied. (shrink)

This paper draws upon a research study of accountants and HR specialists. The study eschewed hypothetical scenarios and focused upon those situations and scenarios that the interviewees defined as causing them ethical concerns. There are two distinct but related issues arising from the paper. The first is that the singular categorisations of moral reasoning attributed to individuals when faced with hypothetical scenarios by many who write on the issue of moral reasoning, did not correspond to the fluidity in moral choices (...) faced by the interviewees as they experienced their unfolding moral dilemmas. The second issue relates to the unwillingness of the interviewees to give voice to their concerns, not only externally, but also within their employing organisations. The tensions within the two cases featured were held in check only by the diminution of the autonomy of the two principal actors. As a consequence, the exercise of moral agency was denied. (shrink)

How is it possible for human subjects who are socially constructed to engage in effective and authoritative acts of resistance to the social norms and institutions within which they were formed? Judith Butler, in her engagement with the work of Pierre Bourdieu, locates this possibility in the nature of `speech acts', and in resistance to social norms emanating from the abjected margins of social life. She criticizes Bourdieu for undermining the promise of agency contained in habitus by reducing it to (...) the social field in which it was constituted, thus re-closing `the iron cage' of structural/institutional determination. For Butler, social norms and institutions, dependent as they are on reiterative performance, are intrinsically open to disruption. It is possible, she claims, using as her example Rosa Parks's historical act of resistance in Montgomery, Alabama in 1955, to resist with authority, yet without prior institutional authorization. This article argues that Butler's theory of iterability works to endow the capacity to authorize against the grain of institutional authority with individuals and their acts and hence neglects the social contexts that inform and de-limit this capacity. `Resisting with authority' is possible precisely because it is not endowed by individuals or their acts, but is collective and interactional. (shrink)

This paper draws upon a recently completed research study of the responses of accountants and HR professionals to actual issues at work that had posed them ethical qualms. The study sought to get beyond ethical reasoning about hypothetical scenarios and to address issues of actual behaviour, focusing upon the interviewees explanations of these behaviours. In general terms there was an observable difference between the attitudes and behaviours of accountants and HR professions, but not in the simple, stereotypical sense. The concerns (...) expressed by the interviewees when calculating their chosen courses of action in a given situation, reflected grave concerns for their current and future employment prospects, if they were to raise their concerns, either within their employing organisation, or beyond. The problems of whistleblowers are well documented, but at a time when corporate governance issues occupy the attention of financial markets and corporate boards around the world, and national governments are introducing new laws to ostensibly provide enhanced protection for whistleblowers, the evidence of this study is that moral agency remains at best an aspiration, and at worst a chimera. (shrink)

Nietzsche appears to adopt a radical Kantian view of objects called constructivism, which holds that the existence of all objects depends essentially on our practices. This essay provides a new reconstruction of Nietzsche's argument for constructivism and responds to five pressing objections to reading Nietzsche as a constructivist that have not been addressed by commentators defending constructivist interpretations of Nietzsche.

This paper argues that Nietzsche is a panpsychist. Panpsychism holds that mental features are ubiquitous and fundamental in reality. I first argue that Nietzsche’s rejection of Cartesian dualism leads him to substance monism. To better understand his monism, I examine Nietzsche’s rejection of Newtonian atomism. Nietzsche holds that bundles of forces, or will to power, are more fundamental than hard, extended atoms. So, will to power is fundamental. I then investigate Nietzsche’s remarks on organic and inorganic nature to show that (...) he believes both are will to power. So, will to power is ubiquitous. The final step to panpsychism is to show that Nietzsche believes will to power exhibits mental qualities. If all goes well, it should emerge that Nietzsche thinks mental features are fundamental and ubiquitous in reality. (shrink)

Nearly every common theory of truth has been attributed to Nietzsche, while some commentators have argued that he simply has no theory of truth. This essay argues that Nietzsche's remarks on truth are best situated within either the coherence or pragmatist theories of truth rather than the correspondence theory. Nietzsche's thoughts on truth conflict with the correspondence framework because he believes that the truth conditions of propositions are constitutively dependent on our actions.

What would the global history of philosophy look like if it were told not as a story of ideas but as a series of job descriptions—ones that might have been used to fill the position of philosopher at different times and places over the past 2,500 years? The Philosopher does just that, providing a new way of looking at the history of philosophy by bringing to life six kinds of figures who have occupied the role of philosopher in a wide (...) range of societies around the world over the millennia—the Natural Philosopher, the Sage, the Gadfly, the Ascetic, the Mandarin, and the Courtier. The result is at once an unconventional introduction to the global history of philosophy and an original exploration of what philosophy has been—and perhaps could be again. By uncovering forgotten or neglected philosophical job descriptions, the book reveals that philosophy is a universal activity, much broader—and more gender inclusive—than we normally think today. In doing so, The Philosopher challenges us to reconsider our idea of what philosophers can do and what counts as philosophy. (shrink)

This is a review of Friedrich Wilhelm Nietzsche, Adrian Del Caro, trans. The Joyful Science / Idylls from Messina / Unpublished Fragments from the Period of The Joyful Science (Spring 1881– Summer 1882): Volume 6 (The Complete Works of Friedrich Nietzsche). Stanford: Stanford University Press, 2023. x + 772 pp. $28.00, paper, ISBN 978-1-5036-3232-5.

The idea that God, understood as the most perfect being, must create the best possible world is often underacknowledged by contemporary theologians and philosophers of religion. This book clearly demonstrates the rationale for what Justin Daeley calls Theistic Optimism and interacts with the existing literature in order to highlight its limitations. While locating Theistic Optimism in the thought of Gottfried Leibniz, Daeley argues that Theistic Optimism is consistent with divine freedom, aseity, gratitude, and our typical modal intuitions. By offering (...) plausible solutions to each of the criticisms levelled against Theistic Optimism, he also provides a vigorous and original defence against the charge that it deviates from the Christian tradition. Engaging with both the Christian tradition and contemporary theologians and philosophers, Why God Must Do What is Best positions the idea of Theistic Optimism firmly within the language of contemporary philosophy of religion. (shrink)

A follow-up to Tiwald's book review of Angle's Sagehood.

ABSTRACT There is a disagreement over how to understand Nietzsche's view of science. According to what I call the Negative View, Nietzsche thinks science should be reconceived or superseded by another discourse, such as art, because it is nihilistic. By contrast, what I call the Positive View holds that Nietzsche does not think science is nihilistic, so he denies that it should be reinterpreted or overcome. Interestingly, defenders of each position can appeal to Nietzsche's understanding of naturalism to support their (...) interpretation. I argue that Nietzsche embraces a social constructivist conception of causality that renders his naturalism incompatible with the views of naturalism attributed to him by the two dominant readings. (shrink)

I contend that Descartes’s view of mind-body union is not a Platonic view in which the soul uses the body as its vehicle, but hylomorphic in that mind and body form a single unit. I argue that Descartes’s view is most like Ockham’s, and therefore Descartes is entitled to maintain a hylomorphic theory to the same extent that Ockham is. I argue further that the soul is the substantial form of human being, and that mind and body are incomplete substances (...) that are substantially united to form the human substance. Finally, I address Descartes’s claim that the whole soul has its principle seat in the pineal gland, and conclude that this does not imply a Platonic view as one might suspect. This hylomorphic interpretation avoids the problem of mind-body interaction, which might be seen as preventing the possibility of the soul’s immortality, because an explanation of the behavior of one entity is required instead of an explanation of the interaction between two, apparently incompatible, entities. (shrink)

This case study documents a high-profile incident involving the world-famous auto maker Daimler Benz with its customers in China. On the one hand, angry customers felt victimized by the auto maker's lack of willingness to take responsibility and its double standard between industrialized markets and emerging economies in dealing with customer complaints; on the other hand, the auto maker also felt frustrated at how this product warranty matter quickly escalated into a public relations nightmare. The case illustrates the complexity of (...) operating in emerging markets where institutional environments are vastly different, and the difficulty of balancing business interests with social responsibility. It also illustrates the urgent needs for emerging markets to develop institutional infrastructure to protect consumer rights, and to offer proper channel for conflict resolution. (shrink)

Nietzsche was persistently concerned with what an object is and how different views of objects lead to different views of facts, causality, personhood, substance, truth, mathematics and logic, and even nihilism. Yet his treatment of objects is incredibly puzzling. In many passages he assumes that objects such as trees and leaves, tables and chairs, and dogs and cats are just ordinary entities of experience. In other places he reports that objects do not exist. Elsewhere he claims that objects exist, but (...) as mere bundles of forces. And sometimes he proposes that we bring all objects into existence. Nietzsche’s writings, then, appear to support various secondary readings, which are jointly inconsistent. My chief aim is to present and defend the reading that Nietzsche embraces constructivism about objects, the neo-Kantian view that all objects are socially constructed. I first explain this view and argue that all non-constructivist readings are not supported by Nietzsche’s texts. I then present Nietzsche’s object constructivism, reconstruct his argument for the position, and defend it from internal objections. I finish by suggesting that Nietzsche might have embraced such a radical conception of objects because it plays a crucial role in overcoming nihilism. (shrink)

It is fairly common in the modern debates over qualia to find assumptions being made about the views of non-philosophers. It is often assumed that the concept is part of the folk theory of consciousness. In fact, even prominent skeptics about qualia will admit that their views run counter to common sense. I illustrate this by considering the work of Daniel Dennett, focusing on his standard articulation of the debate concerning his heterophenomenological method. While Dennett is often accused of not (...) going far enough (excluding qualia from the catalog of what needs to be explained by a science of consciousness), I argue that he goes too far in accepting that folk psychological utterances should be interpreted in terms of beliefs about qualia. I support this contention by calling on the results of six empirical studies testing Dennett’s theory of the folk theory of consciousness. (shrink)

Arnauld raised the concern that Descartes’s real distinction argument proved too much, because it seemed to lead us back to the Platonic view according to which the mind uses the body as its vehicle. Descartes responds by pointing out that he argued against this account of mind-body union in the Sixth Meditation. Descartes believes he did not prove too much, because he offers an argument against this view whose premises and conclusion are consistent with the real distinction argument. In this (...) paper, the union argument is reconstructed and evaluated in order to see if, through his rejection of the Platonic view, Descartes adequately addresses Arnauld’s concern. In the end, Descartes adequately addresses this concern only if God’s veracity provides a secure foundation for a crucial inference. Finally, these considerations show a way for those committed to the real distinction of mind and body to avoid the problem of their interaction. (shrink)

I clarify Hegel’s role in the Europeanization of philosophy over the course of the 19th century. I begin with an investigation of the way non-Western philosophy was conceptualized in Europe before, and after, I move on to a consideration of the debates about philosophy that emerged in late 19th century China because of European attempts, such as that of Hegel, to circumscribe the geographical and civilizational scope of this discipline. How may we see the emergence of a distinctly modern, generally (...) nationalist, discourse about “Chinese philosophy” within China as a reflection of larger global processes then taking place? (shrink)

If anyone ever lived up to our image of a baroque Universalgelehrter, it may have been the Jesuit natural philosopher Athanasius Kircher, whose life and interests spanned most of the 17th century. In his prolific career, Kircher wrote at least 14 major works, on subjects as varied as light, magnetism, music, geology, combinatorics, and Sinology. Thomas Leinkauf’s thorough, penetrating study of Kircher’s life and work does a tremendous job of making the Jesuit’s work both comprehensible and fascinating, as well as (...) granting us a vision of the inner workings of Kircher’s mind, a mind formed both by his period and his position in the history of ideas, and driven by an unusual creativity and capacity for synthesis. (shrink)