The transport of messenger RNAs (mRNAs) from the nucleus to cytoplasm is an essential step in the gene expression program of all eukaryotes. Recent technological advances in the areas of RNA‐labeling, microscopy, and sequencing are leading to novel insights about mRNA biogenesis and export. This includes quantitative single molecule imaging (SMI) of RNA molecules in live cells, which is providing knowledge of the spatial and temporal dynamics of the export process. As this information becomes available, it leads to new questions, (...) the reinterpretation of previous findings, and revised models of mRNA export. In this review, we will briefly highlight some of these recent findings and discuss how live cell SMI approaches may be used to further our current understanding of mRNA export and gene expression. (shrink)

Planar cell polarity (PCP) refers to the polarization of a field of cells within the plane of a cell sheet. This form of polarization is required for diverse cellular processes in vertebrates, including convergent extension (CE), the establishment of PCP in epithelial tissues and ciliogenesis. Perhaps the most distinct example of vertebrate PCP is the uniform orientation of stereociliary bundles at the apices of sensory hair cells in the mammalian auditory sensory organ. The establishment of PCP in the mammalian cochlea (...) occurs concurrently with CE in this ciliated epithelium, therefore linking three cellular processes regulated by the vertebrate PCP pathway in the same tissue and emerging as a model system for dissecting PCP signaling. This review summarizes the morphogenesis of this model system to assist the interpretation of the emerging data and proposes molecular mechanisms underlying PCP signaling in vertebrates. BioEssays 29: 120–132, 2007. © 2007 Wiley Periodicals, Inc. (shrink)

One lists the distinct pairs of categorical premises formulable via only the positive terms, S,P,M, by constructing a six by six matrix obtained by pairing the six categorical P-premises, A, O, A, O, where P* ∈ {P,P′}, with the six, similar, categorical S-premises. One shows how five rules of valid syllogism, select only 15 distinct PCPs that entail logical consequences belonging to the set L+: = {A, O, A, E, O, I}. The choice of admissible LCs can be regarded as (...) a condition separated from the conditions contained in the RofVS: the usual eight PCPs that generate valid syllogisms are obtained when the only admissible LCs belong to the set L: = {A, E, O, I} and no existential imports are addressed. A 64 PCP-matrix obtains when both PCPs and LCs may contain indefinite terms—the positive, S,P,M, terms, and their complementary sets, S′,P′, M′, in the universe of discourse, U, called the negative terms. Now one can accept eight LCs: A, I, where P* ∈ {P,P′}, S* ∈ {S,S′}, and there are 32 conclusive PCPs, entailing precise, “one partitioning subset of U” LCs. The four rules of conclusive syllogisms predict the less precise LCs, left after eliminating the middle term from the exact LCs. The RofCS also predict that the other 32 PCPs of the 64 PCP-matrix are non-conclusive. The RofVS and the RofCS are generalized, and arguments are given, for also accepting as valid syllogisms the conclusive syllogisms formulable via positive terms which entail the LCs A and O. (shrink)

Trust is widely recognised is a core feature of partnership relationships and one that facilitates joint work. It is an issue that must be addressed if partnerships are to enhance service system integration. In recent literature trust has been linked to concepts of risk and control. In this study of trust within a Primary Care Partnership (PCP) in Australia the experiences of risk and uncertainty, and control, of participants in different structural positions, were explored in detail. The data used (...) in this paper was qualitative, derived from 63 interviews with managers and service providers participating in committees of the PCP. This paper reports on the differences in the experience of risk and uncertainty, trust and control, of managers and service providers working as boundary spanners through the committees of a PCP. For managers there were significant risks and uncertainties, and trust and control were important. For service providers there were few risks and uncertainties, and trust and control were of much less importance. Some policy implications of the differences in perspective are discussed, as are important areas for further research. (shrink)

Planar cell polarity (PCP), the alignment of cells within 2D tissue planes, involves a set of core molecular regulators highly conserved between animals and cell types. These include the transmembrane proteins Frizzled (Fz) and VanGogh and the cytoplasmic regulators Dishevelled (Dsh) and Prickle. It is widely accepted that this core forms part of a ‘PCP pathway’ for signal transduction, which can affect cell morphology through activation of an evolutionary ancient regulatory module involving Rho family GTPases and Myosin II, and/or the (...) JNK kinase cascade. We have re‐examined the evidence for interactions between the proposed PCP pathway components, and question the placing of the cell morphology regulators in the same pathway as the PCP core. While Fz and Dsh are clearly involved in both PCP and Rho‐based cell morphology regulation, available evidence cannot currently discriminate whether these processes are linked mechanistically by a shared Fz/Dsh population, or pass by two distinct pathways. (shrink)

Here, for the first time, development studies encounters the set of ideas popularly known as 'Chaos Theory'. Samir Rihani applies to the processes of economic development, ideas from complex adaptive systems like uncertainty, complexity, and unpredictability. Rihani examines various aspects of the development process - including the World Bank, debt, and the struggle against poverty - and demonstrates the limitations of fundamentally linear thinking in an essentially non-linear world.

1 Einleitung: Die konstruktivistische Herausforderung strukturgenetischer Subjekttheorien........................................................ 11 1. 1 Sozialisationstheorie - jenseits der groBen Entwiirfe......................................... 17 1. 2 Der genetische Strukturalismus im Kontext theoretischer Leitunterscheidungen................................................................................ ....... 20 1. 3 Konstitution als Problemstellung...................................................................... 27 2 Strukturgenetischer und radikaler Konstruktivismus........................... 33 2. 1 Die Erkenntnistheorie des Radikalen Konstruktivismus vor dem Hintergrund einer interaktionistischen strukturgenetischen Theoriestrategie.................................................................................... ........... 36 2. 1. 1 "Realitat" und "Wirklichkeit"........................................................................... 37 2. 1. 2 Konstruktivitat und AuBenwe1t: Piaget und von Glasersfeld............................. 41 2. 1. 3 Abgeschlossenheit, Rekursivitat und strukturelle Koppelung........................... 46 (...) 2. 2 Aquilibration und Adaption - Die differenztheoretische Ausgangslage des strukturgenetischen Konstruktivismus Piagets..................... 51 2. 3 Differenzerfahrung und die Entstehung des Neuen........................................... 54 2. 4 Der Status strukturgenetischer Fragestellungen vor dem Hintergrund des radikalen Konstruktivismus.................................................... 57 3 Soziale Konstitutions- und Systemtheorie.............................................. 62 3. 1 Die soziale Konstitutionshypothese.................................................................. 64 3. 2 Sprachzentrismus und Regelontologie.............................................................. 70 3. 3 Sinn als Grundbegriffund die Eigenstiindigkeit des Sozialen.......................... 72 3. 4 Das Problem der doppelten Kontingenz........................................................... 76 3. 5 Interpenetration und strukturelle Koppelung.................................................... 84 3. 6 Differenz und Identitat in der System- und sozialen Konstitutionstheorie......... 89 3. 7 Zwischenbilanz und Konsequenzen fur die Konzeption des Anfangsproblems 92 5 4 Die Konstitution der Subjekt-Objekt-Differenz: Das grundlegende Bezugsproblem des interaktionistischen Konstruktivismus...................................... 97 4. 1 Die Subjekt-Objekt-Differenzierung im genetischen Strukturalismus Piagets.................... 100 4. 1. 1 Die Ausgangskonstellation............................................ 102 4. 1. 2 1m Reich der Metaphem: Die Rolle der AuBenwelt und der Akkommodation........................................................................ 106 4. 1. 3 Die primaren und sekundaren Zirkularreaktionen im Blick des radikalen Konstruktivismus........................................................ III 4. 1. 4 Die Ausbildung der Subjekt-Objekt-Gegenlage.......................................... (shrink)

Dass Edmund Husserl am Problem der Intersubjektivität gescheitert ist, gilt als ausgemacht - und ebenso, welche Konsequenzen daraus zu ziehen sind. Entgegen dem allenthalben pauschal erklärten `Abschied vom Subjekt' spricht aber vieles dafür, dass es in der gegenwärtigen Sozialtheorie eher um eine Reformulierung transzendentaler Subjektivität geht. Diese Interpretationsthese wirft ein neues Licht auf den sozialtheoretischen Diskurs, der im deutschen Sprachraum in den vergangenen dreissig Jahren vom Gegensatz von Jürgen Habermas' und Niklas Luhmanns Theorien bestimmt war: `Diskurs' und `System' erscheinen (...) als gegensätzliche Versuche, `Subjektivität' und `Interität' in ein theoretisch befriedigendes Verhältnis zu setzen. Wenn aber - so die kritische These dieses Buches - weder die Reformulierung von Subjektivität als `Interität' noch die Reformulierung von Subjektivität ohne `Interität' das Problem der Intersubjektivität überzeugend löst, ist dies ein Grund, neuerlich in eine direkte Auseinandersetzung mit Husserls Theorie transzendentaler Subjektivität einzutreten. Dabei stellt sich heraus, dass Husserls vielkritisierter und -skandalisierter Versuch, den Sinn `Anderer' im `Eigenen' zu fundieren, in der transzendentalphänomenologischen Subjekttheorie durch ein umgekehrtes Begründungsverhältnis konterkariert wird. Bei aller Problematik dieser Theorieanlage - welche nur in Gegenwendung zu den Gewohnheiten der Husserl-Interpretation, vor allem aber auch zu Husserls Selbstinterpretation in den Blick kommt - zeigt sich, dass der phänomenologische Begriff des transzendentalen Subjekts seinen Reformulierungen als Diskurs und als System in mancher Hinsicht überlegen ist. (shrink)

According to the standard view in philosophy, intentionality is the mark of genuine action. In psychology, human cognition and agency are now widely explained in terms of the workings of two distinct systems (or types of processes), and intentionality is not a central notion in this dual-system theory. Further, it is often claimed, in psychology, that most human actions are automatic, rather than consciously controlled. This raises pressing questions. Does the dual-system theory preserve the philosophical account of intentional (...) action? How much of our behavior is intentional according to this view? And what is the role of consciousness? I will propose here a revised account of intentional action within the dual-system framework, and we will see that most of our behavior can qualify as intentional, even if most of it is automatic. An important lesson will be that philosophical accounts of intentional action need to pay more attention to the role of consciousness in action. (shrink)

There is contrast to the belief that all energy and matter came into existence after the Big Bang. If we wish to understand the way the Greeks and other philosophers view our environment, we need to study the data that was collected by them. This book sees our portrayal of reality as having its departure point in concrete systems by which means of conceptual systems result in abstracted systems. This data must be sorted and information must now be surveyed, structured, (...) and analysed to find qualities and connections between the different aspects systems thinking. This has led to the theory for 'Living Systems'. It gives examples of applications which a basis for further studies of systems can be formed. The Internet now provides a major advantage to the retrieval of statistical information and opens a means for the future exploration and verification of how systems work. (shrink)

Die Frage, ob «systematische» Philosophie heute noch möglich ist, wird in der Gegenwartsphilosophie kontrovers diskutiert. Sie ist eng verknüpft mit dem Thema «Vernunft und Wirklichkeit». Der Sammelband System der Philosophie? dokumentiert Aspekte dieser Debatte durch Beiträge einer internationalen Autorenschaft.

The paper discusses how systems biology is working toward complex accounts that integrate explanation in terms of mechanisms and explanation by mathematical models—which some philosophers have viewed as rival models of explanation. Systems biology is an integrative approach, and it strongly relies on mathematical modeling. Philosophical accounts of mechanisms capture integrative in the sense of multilevel and multifield explanations, yet accounts of mechanistic explanation have failed to address how a mathematical model could contribute to such explanations. I discuss how mathematical (...) equations can be explanatorily relevant. Several cases from systems biology are discussed to illustrate the interplay between mechanistic research and mathematical modeling, and I point to questions about qualitative phenomena, where quantitative models are still indispensable to the explanation. Systems biology shows that a broader philosophical conception of mechanisms is needed, which takes into account functional-dynamical aspects, interaction in complex networks with feedback loops, system-wide functional properties such as distributed functionality and robustness, and a mechanism’s ability to respond to perturbations. I offer general conclusions for philosophical accounts of explanation. (shrink)

Systems biology is a vigorous and expanding discipline, in many ways a successor to genomics and perhaps unprecendented in its combination of biology with a ...

This two-volume work, first published in 1843, was John Stuart Mill's first major book. It reinvented the modern study of logic and laid the foundations for his later work in the areas of political economy, women's rights and representative government. In clear, systematic prose, Mill (1806–73) disentangles syllogistic logic from its origins in Aristotle and scholasticism and grounds it instead in processes of inductive reasoning. An important attempt at integrating empiricism within a more general theory of human knowledge, the work (...) constitutes essential reading for anyone seeking a full understanding of Mill's thought. Volume 1 contains Mill's introduction, which elaborates upon his definition of logic as 'not the science of Belief, but the science of Proof, or Evidence'. It also features discussions of the central components of logical reasoning - propositions and syllogisms - in relation to Mill's theories of inductive reasoning and experimental method. (shrink)

Minimizing the costs that others impose upon oneself and upon those in whom one has a fitness stake, such as kin and allies, is a key adaptive problem for many organisms. Our ancestors regularly faced such adaptive problems (including homicide, bodily harm, theft, mate poaching, cuckoldry, reputational damage, sexual aggression, and the infliction of these costs on one's offspring, mates, coalition partners, or friends). One solution to this problem is to impose retaliatory costs on an aggressor so that the aggressor (...) and other observers will lower their estimates of the net benefits to be gained from exploiting the retaliator in the future. We posit that humans have an evolved cognitive system that implements this strategy – deterrence – which we conceptualize as a revenge system. The revenge system produces a second adaptive problem: losing downstream gains from the individual on whom retaliatory costs have been imposed. We posit, consequently, a subsidiary computational system designed to restore particular relationships after cost-imposing interactions by inhibiting revenge and motivating behaviors that signal benevolence for the harmdoer. The operation of these systems depends on estimating the risk of future exploitation by the harmdoer and the expected future value of the relationship with the harmdoer. We review empirical evidence regarding the operation of these systems, discuss the causes of cultural and individual differences in their outputs, and sketch their computational architecture. (shrink)

D'Holbach believed that the misery he saw in mankind around him was caused by religion and its superstitious beliefs - that there was a God who controlled destiny and would reward and punish individuals. The System of Nature was written to replace these delusions with a schema of understanding based solely on the physical workings of nature.

Background There are intense discussions about the ethical and societal implications of biomedical engineering, but little data to suggest how scientists think about the ethics of their work. The aim of this study is to describe how scientists frame the ethics of their research, with a focus on the field of molecular systems engineering.Methods Semi-structured qualitative interviews were conducted during 2021–2022, as part of a larger study. This analysis includes a broad question about how participants view ethics as related to (...) their work, with follow up probes about the topics they consider most important. Interviews were transcribed, inductively coded by two researchers to consensus, and analyzed thematically.Results Twenty-four scientists participated in the study. Interviewees hold positions as professors, principal investigators, and senior staff researchers in universities or research institutes in the United States and Europe. Among those scientists who reported reflecting on ethical considerations in their work, many equated ethics with research ethics topics (e.g., safety, replicability), or with regulation and guidelines. Participants expressed the view that ethical issues are primarily relevant for clinical trials of bioengineered products, or for those working with animal or human subjects. Scientists described their research as “too early” or “not examining anything living” with regard to ethical reflection. Finally, many felt that ethics is seen as territory for experts and therefore beyond scientists’ competencies.Conclusions Molecular systems engineering scientists currently focus on regulatory aspects as the framework for their ethical analyses. They describe using a framework to define when life arises, as a means to determine when further ethical engagement is warranted. Further research is needed to investigate how scientists relate to the ethics of their scientific work, and build consensus around concepts of life, autonomous behavior, and physiological relevance of bioengineered systems. (shrink)

Germany's leading contemporary social theorist provides a definitive analysis of art as a social and perceptual system which not only represents an important intellectual step in discussions of art but also an important advance in systems theory. Luhmann insists on the radical incommensurability between psychic systems (perception) and social systems (communication). Art is a special kind of communication that operates at the boundary between the social system and consciousness in ways that profoundly irritate communication while remaining strictly internal (...) to the social. Each chapter elaborates a particular aspect of the general problem of art's status as a social system. The book draws on a vast body of research in the social sciences, phenomenology, evolutionary biology, cybernetics, and information theory, combined with an intimate knowledge of art history, literature, aesthetics, and contemporary literary theory. The book also engages virtually every major theorist of art and aesthetics from Baumgarten to Derrida. (shrink)

Ethologists and others studying animal behavior in a spirit are in need of a descriptive language and method that are neither anachronistically bound by behaviorist scruples nor prematurely committed to particular Just such an interim descriptive method can be found in intentional system theory. The use of intentional system theory is illustrated with the case of the apparently communicative behavior of vervet monkeys. A way of using the theory to generate data - including usable, testable data - is (...) sketched. The underlying assumptions of this approach can be seen to ally it directly with theorizing in evolutionary biology, which has recently come under attack from Stephen Gould and Richard Lewontin, who castigate it as the Their arguments, which are strongly analogous to B. F, Skinner's arguments against point to certain pitfalls that attend the careless exercise of such thinking (and rival varieties of thinking as well), but do not constitute a fundamental objection to either adaptationist theorizing or its cousin, intentional system theory. (shrink)

Das System der Disponibilitätshierarchien versucht in der Rechtsphilosophie eine neue Perspektive zu eröffnen, indem speziell das Phänomen der Disponibilitätssetzung und seiner Auswirkungen auf die Umgangsmöglichkeiten und Urteilsmacht des Menschen in der Gesellschaft betrachtet wird. Die Disponibilitätshierarchie der Umgangsmöglichkeit und die Disponibilitätshierarchie der Urteilsmacht dienen dem Aufbau eines neuen Freiheitsbegriffes. Mit der Darstellung des Aufbaus der Statikexistenziale und der Dynamikexistenziale begründet das Werk einen neuen Freiheitsbegriff und überschreitet damit die Grenze der Rechtsphilosophie hin zur Allgemeinphilosophie. In der antiken und in (...) der klassischen Philosophie wurde Freiheit zumeist als Möglichkeit, in der absoluten Daseinsform aufzugehen, verstanden. Kant hat die Möglichkeit der absoluten Eigenursächlichkeit eines gedanklichen Ereignisses für den Folgegedankengang und Ereignisablauf als transzendentale Freiheit verstanden und als notwendige Bedingung der konkreten praktischen Freiheit, die er Selbstautonomie nannte, angesehen. Die moderne Philosophie sieht zumeist in der größtmöglichen materiellen und ideellen Ungebundenheit die Freiheit, die negative Freiheit als Freiheit von Zwängen ist. In diesem Buch wird herausgearbeitet, daß Freiheit ambivalent erstrebt wird durch den Aufbau von Statik- und Dynamikexistenzialen. Der Autor, geb. 1969, absolvierte ein Studium der Rechtswissenschaft an der Universität Freiburg im Breisgau und unternahm darüber hinaus Studien zur Allgemeinphilosophie. Er ist derzeit Rechtsreferendar am Landgericht Freiburg. (shrink)

There is no doubt that custard apple diseases are among the important reasons that destroy the Custard Apple plant and its agricultural crops. This leads to obvious damage to these plants and they become inedible. Discovering these diseases is a good step to provide the appropriate and correct treatment. Determining the treatment with high accuracy depends on the method used to correctly diagnose the disease, expert systems can greatly help in avoiding damage to these plants. The expert system correctly (...) diagnoses Custard Apple disease to make it easier for farmers to find the right treatment based on the appropriate diagnosis. Objectives: A specialized syllable language system was established for the diagnosis of Custard Apple plant disease. (shrink)

From its genesis in the 1960s, the focus of inquiry in neuroscience has been on the cellular and molecular processes underlying neural activity. In this pursuit neuroscience has been enormously successful. Like any successful scientific inquiry, initial successes have raised new questions that inspire ongoing research. While there is still much that is not known about the molecular processes in brains, a great deal of very important knowledge has been secured, especially in the last 50 years. It has also attracted (...) the attention of a number of philosophers, some of whom have viewed it as evidence for a ruthlessly reductionistic program that will eventually explain how mental processes are performed in the brain in purely molecular terms. As neuroscience developed, however, there emerged a smaller group of researchers who focused on systems, behavioral, and cognitive neuroscience. These investigators have also made impressive advances in the last 50 years and they have been the focus of an even larger group of philosophers, who have appealed to systems level understanding of the brain as providing the appropriate point of connection to the information processing accounts advanced in psychology. (shrink)

This chapter examines the pioneering work of Gottfried Wilhelm Leibniz (1646-1716) on various number systems, in particular binary, which he independently invented in the mid-to-late 1670s, and hexadecimal, which he invented in 1679. The chapter begins with the oft-debated question of who may have influenced Leibniz’s invention of binary, though as none of the proposed candidates is plausible I suggest a different hypothesis, that Leibniz initially developed binary notation as a tool to assist his investigations in mathematical problems that were (...) exercising him at the time, namely those concerning the divisibility of composite numbers, primality, and perfect numbers. The chapter then explores Leibniz’s development of binary, his little-known work on binary fractions and expansions, his use of binary as a symbol for creation in his philosophical-theology, and his response to the suggestion that there was a correlation between binary numeration and the hexagrams of the ancient Chinese divinatory text, the Yijing. The chapter then focuses on Leibniz’s work on other number systems, in particular his invention and exploration of hexadecimal as well as his work on duodecimal. The chapter concludes by revealing a hitherto unknown practical application of binary that Leibniz devised in the last year of his life. (shrink)

This paper discusses the epistemic status of biology from the standpoint of the systemic approach to living systems based on the notion of biological autonomy. This approach aims to provide an understanding of the distinctive character of biological systems and this paper analyses its theoretical and epistemological dimensions. The paper argues that, considered from this perspective, biological systems are examples of emergent phenomena, that the biological domain exhibits special features with respect to other domains, and that biology as a discipline (...) employs some core concepts, such as teleology, function, regulation among others, that are irreducible to those employed in physics and chemistry. It addresses the claim made by Jacques Monod that biology as a science is marginal. It argues that biology is general insofar as it constitutes a paradigmatic example of complexity science, both in terms of how it defines the theoretical object of study and of the epistemology and heuristics employed. As such, biology may provide lessons that can be applied more widely to develop an epistemology of complex systems. (shrink)

In this chapter we explore basic mathematical and other constraints which limit the often novel uses of computation employed in modern computational system biology. These constraints generate substantial obstacles for one goal prominent in the field; namely, the goal of producing models valid for predictive uses in clinical and other contexts. However on closer examination many applications of computation and simulation in the field have more pragmatic or investigative goals in mind, suggesting an important role for rationalizing uses of (...) computation in systems biology and elsewhere as investigative tools. We discuss the concept of an “investigative tool”, and what insights it might offer our understanding of modern computational strategies and the bases for them. (shrink)

In this essay, I focus on two questions. First, what is Kant's understanding of the sense in which our faculties form a unified system? And, second, what are the implications of this for the metaphysical relationships between the faculties within this system? To consider these questions, I begin with a brief discussion of Longuenesse's groundbreaking work on the teleological unity of the understanding as the faculty for judgment. In doing so, I argue for a generalization of Longuenesse's account (...) along two dimensions. The result is a picture of our faculties as forming a teleological system—unified under the overarching aims of reason as the highest rational faculty. Then I discuss the recent debate between “additive” and “transformative” interpretations of the relationship between sensibility and the understand- ing, before proposing that we should interpret Kant as endorsing a moderate form of the “transformative” reading, which captures important elements of both the “additive” and the “transformative” account. (shrink)

The relationship between abstract formal procedures and the activities of actual physical systems has proved to be surprisingly subtle and controversial, and there are a number of competing accounts of when a physical system can be properly said to implement a mathematical formalism and hence perform a computation. I defend an account wherein computational descriptions of physical systems are high-level normative interpretations motivated by our pragmatic concerns. Furthermore, the criteria of utility and success vary according to our diverse purposes (...) and pragmatic goals. Hence there is no independent or uniform fact to the matter, and I advance the ‘anti-realist’ conclusion that computational descriptions of physical systems are not founded upon deep ontological distinctions, but rather upon interest-relative human conventions. Hence physical computation is a ‘conventional’ rather than a ‘natural’ kind. (shrink)

The logic $G3^{<}_{{{}^{\scriptsize{-}}}\!\!\textrm{L}}$ was introduced in Robles and Mendéz as a paraconsistent logic which is based on Gödel’s 3-valued matrix, except that Kleene–Łukasiewicz’s negation is added to the language and is used as the main negation connective. We show that $G3^{<}_{{{}^{\scriptsize{-}}}\!\!\textrm{L}}$ is exactly the intersection of $G3^{\{1\}}_{{{}^{\scriptsize{-}}}\!\!\textrm{L}}$ and $G3^{\{1,0.5\}}_{{{}^{\scriptsize{-}}}\!\!\textrm{L}}$, the two truth-preserving 3-valued logics which are based on the same truth tables. We then construct a Hilbert-type system which has for $\to $ as its sole rule of inference, and (...) is strongly sound and complete for $G3^{<}_{{{}^{\scriptsize{-}}}\!\!\textrm{L}}$. Then we show how, by adding one axiom or one new rule of inference, we get strongly sound and complete systems for $G3^{\{1\}}_{{{}^{\scriptsize{-}}}\!\!\textrm{L}}$ and $G3^{\{1,0.5\}}_{{{}^{\scriptsize{-}}}\!\!\textrm{L}}$. Finally, we provide quasi-canonical Gentzen-type systems which are sound and complete for those logics and show that they are all analytic, by proving the cut-elimination theorem for them. (shrink)

The notion of cognitive system is widely used in explanations in cognitive psychology and neuroscience. Traditional approaches define cognitive systems in an agent-relative way, that is, via top-down functional decomposition that assumes a cognitive agent as starting point. The extended cognition movement challenged that approach by questioning the primacy of the notion of cognitive agent. In response, [Adams, F., and K. Aizawa. 2001. The Bounds of Cognition. Oxford, UK: Wiley-Blackwell.] suggested that to have a clear understanding of what a (...) cognitive system is we may need to solve “the demarcation challenge”: the problem of identifying a reliable way to determine which mechanisms that are causally responsible for the production of a certain cognitive process constitute a cognitive system responsible for such process and which ones do not. Recently, [Rupert, R. 2009. Cognitive Systems and the Extended Mind. Oxford: Oxford University Press.] offered a solution based on the idea that the mechanisms that constitute a cognitive system are integrated in a particular sense. In this paper I critically review Rupert’s solution and argue against it. Additionally, I argue that a successful account of cognitive system must accommodate the fact that the neural mechanisms causally responsible for the production of a cognitive process are diachronically dynamic and yet functionally stable. At the end, I offer a suggestion as to how to accommodate this diachronic dynamicity without losing functional stability. I conclude by drawing some implications for the discussion on cognitive ontologies. (shrink)

Abstract: Background: In spite of the fact that computers continue to improve in speed and functions operation, they remain complex to use. Problems frequently happen, and it is hard to resolve or find solutions for them. This paper outlines the significance and feasibility of building a desktop PC problems diagnosis system. The system gathers problem symptoms from users’ desktops, rather than the user describes his/her problems to primary search engines. It automatically searches global databases of problem symptoms and (...) solutions, and also allows ordinary users to contribute exact problem reports in a structured manner. Objectives: The main goal of this Knowledge Based System is to get the suitable problem desktop PC symptoms and the correct way to solve the errors. Methods: In this paper the design of the proposed Knowledge Based System which was produced to help users of desktop PC in knowing many of the problems and error such as : Power supply problems, CPU errors, RAM dumping error, hard disk errors and bad sectors and suddenly restarting PC. The proposed Knowledge Based System presents an overview about desktop PC hardware errors are given, the cause of fault are outlined and the solution to the problems whenever possible is given out. CLIPS Knowledge Based System language was used for designing and implementing the proposed expert system. Results: The proposed PC desktop troubleshooting Knowledge Based System was evaluated by IT students and they were satisfied with its performance. (shrink)

This article presents the first, systematic analysis of the ethical challenges posed by recommender systems through a literature review. The article identifies six areas of concern, and maps them onto a proposed taxonomy of different kinds of ethical impact. The analysis uncovers a gap in the literature: currently user-centred approaches do not consider the interests of a variety of other stakeholders—as opposed to just the receivers of a recommendation—in assessing the ethical impacts of a recommender system.

Background: The castor bean is a large grassy or semi-wooden shrub or small tree. Any part of the castor plant parts can suffering from a disease that weakens the ability to grow and eliminates its production. Therefore, in this paper will identify the pests and diseases present in castor culture and detect the symptoms in each disease. Also images is showing the symptom form in this disease. Objectives: The main objective of this expert system is to obtain appropriate diagnosis (...) of the disease. Methods: In this paper, the expert system is designed for the ability of agricultural engineers to detect and diagnose disease of castor like as: seeding blight, alternaria blight, cercospora leaf spot, powdery mildew and wilt. This system presents the disease symptoms, survival and spread, favorable conditions and image for each disease. Clips and Delphi expert system languages are used for designing and implementing the proposed expert system. Results: The expert system in the diagnosis of castor diseases was assessed by farmers and agricultural engineers and they were satisfied and accepted with its quality of performance. Conclusions: The expert system is easy for farmers and people have experience in the plant of castor to detect and diagnosis the symptoms that may face this plant from several disease. (shrink)

PurposeThe purpose of this paper is to explore a particular philosophical underpinning for Information Systems (IS) research – critical systemic thinking (CST). Drawing upon previous work, the authors highlight the principal features of CST within the tradition of critical research and attempt to relate it to trends in the Italian school of IS research in recent years, as exemplified by the work of Claudio Ciborra but also evident in work by, e.g. Resca, Jacucci and D'Atri.Design/methodology/approachThis is a conceptual paper which (...) explores CST, characterised by a focus on individual uniqueness, and socially‐constructed, individual worldviews as generators of human knowing.FindingsThe paper draws on work by Heinz Klein in which he elaborated three constitutive stages in critical research: interpretive, genealogical and constructive. The authors introduce a fourth, reflective stage and discuss five categories of critical research, reflecting different perspectives on emancipation, culminating in emergent expressionism, associated with Ciborra and the Italian school more generally.Research limitations/implicationsThis paper discusses approaches to CST and how they might have practical implications in IS development. The distinction between approaches founded in logical empiricism and those founded in hermeneutic dialectics are considered and the development of critical and systems strands are discussed.Practical implicationsThe paper addresses CST as an approach to development of information systems. Such approaches enable users to explore their individually unique understandings and create a constructive dialogue with one another, which emancipates and empowers users to own and control their own development processes and hence build more productive and usable systems.Social implicationsA focus on research which is oriented towards emancipation in the tradition of critical social theory.Originality/valueThe paper draws on extensive theoretical research carried out by the authors over a period of more than ten years in CST and synthesises the practical implications. (shrink)

Robert Rupert argues against the view that human cognitive processes comprise elements beyond the boundary of the organism, developing a systems-based conception in place of this extended view. He also argues for a conciliatory understanding of the relation between the computational approach to cognition and the embedded and embodied views.