The BTB domain is a protein–protein interaction motif that is found throughout eukaryotes. It determines a unique tri‐dimensional fold with a large interaction surface. The exposed residues are highly variable and can permit dimerization and oligomerization, as well as interaction with a number of other proteins. BTB‐containing proteins are numerous and control cellular processes that range from actin dynamics to cell‐cycle regulation. Here, we review findings in the field of transcriptional regulation to illustrate how the high variability of the BTB (...) has allowed related transcription factors to evolve different functional abilities. We then report how recent work has showed that, in spite of their high sequence divergence and apparently unrelated functions, many BTB‐containing proteins have at least one shared role: the recruitment of degradation targets to E3 ubiquitin ligase complexes. Taken together, these findings illustrate diverse and convergent functions of a versatile protein–protein interaction domain. BioEssays 28: 1194–1202, 2006. © 2006 Wiley Periodicals, Inc. (shrink)

Context In some cases, physicians estimate that continuous sedation until death may have a life-shortening effect. The accuracy of these estimations can be questioned.Aim The aim of this study is to compare two approaches to estimate the potential life-shortening effect of continuous sedation until death.Methods In 2008, 370 Dutch physicians filled out a questionnaire and reported on their last patient who received continuous sedation until death. The potential life-shortening effect of continuous sedation was estimated through a direct approach and an (...) indirect approach . The intrarater agreement between both approaches was determined with a weighted κ.Results According to the direct approach, sedation might have had a life-shortening effect in 51% of the cases and according to the indirect approach in 84%. The intrarater agreement between both approaches was fair . In 10% of all cases, the direct approach yielded higher estimates of the extent to which life had been shortened; in 58% of the cases, the indirect approach yielded higher estimates.Conclusions The results show a discrepancy between different approaches to estimate the potential life-shortening effect of continuous sedation until death. (shrink)

This investigation explains the causes that triggered the so-called “Caso Almería”. An event that involved the torture and murder of three young men –Luis Cobo Mier, Juan Mañas Morales and Luis Montero García– by civil guards after mistaking them for members of the terrorist organisation Euskadi Ta Askatasuna. In order to prepare it, documentation from different archives, oral testimonies such as that of Lieutenant General Andrés Cassinello Pérez, as well as press reports on this event were used. The conclusion reached (...) is that this was not a case of state terrorism, but rather a vindictive and uncontrolled action by members of the Guardia Civil, linked to the ETA attack on Lieutenant General Joaquín de Valenzuela, and covered up by the commanders of this police force and the government itself. (shrink)

No presente trabalho, vamos abordar algumas das questões essenciais sobre o imaginário coletivo e suas relações com a realidade e a verdade. Devemos encarar esse assunto em uma estrutura conceptual, seguida pela análise factual correspondente às realidades comportamentais demonstráveis. Adotaremos não apenas a metodologia, mas principalmente os princípios e proposições da filosofia analítica, que com certeza serão evidentes ao longo do estudo e podem ser identificados pelos recursos descritos por Perez[1] : Rabossi (1975) defende a ideia de que a (...) filosofia analítica pode ser identificada considerando-se certas semelhanças familiares. Ele sugere os seguintes traços familiares: uma atitude positiva em relação ao conhecimento científico; uma atitude cautelosa em relação à metafísica; uma concepção da filosofia como uma tarefa conceptual, que toma a análise conteudo como um método; uma estreita relação entre linguagem e filosofia; uma preocupação em buscar respostas argumentativas para problemas filosóficos, e procura de clareza conceptual. Esses conceitos centrais envolvem conteúdos culturais, sociais, religiosos, científicos, filosóficos, morais e políticos, pertencentes à existência individual e coletiva de cada um de nós. Neste artigo, não discutiremos nem demonstraremos. Nosso objetivo não é o de sistematicamente criticar ou evidenciar qualquer coisa, de qualquer maneira. O presente trabalho se baseia na reflexão analítica. Apenas especularemos da maneira mais abrangente e profunda que pudermos e expressaremos os resultados de nossos pensamentos. Não obstante a natureza multidisciplinar do assunto e a abertura metodológica para aceitar contribuições de qualquer campo da ciência, este trabalho pertence ao objetivo da psicologia e ontologia ou, em outros termos, da psicologia social e ontológica. A metodologia livre que norteia tais reflexões abrange e leva em consideração tudo o que se aproxima da coerência com a epistemologia filosófica e psicológica. Essa metodologia não busca alcançar evidências, mas apenas procura a inter-relação entre evidências já existentes, de qualquer natureza e magnitude, inferindo um significado coerente para as coisas reais. Muitos dos grandes pensadores, a qualquer momento, nunca procuraram demonstrações, teorizações ou sistematizações. Esses pensadores apenas pensavam, meditavam e com a iluminação de sua humildade podiam se aproximar da verdade. Eles serão nossa referência e o exemplo a ser seguido. Com certeza, não encontraremos a verdade, mas podemos ter certeza de alguma coisa: em muitos momentos, chegaremos perto da verdade e, em todos os momentos, estaremos nos afastando da inverdade e da mentira. O escopo principal deste estudo é observar como alguns dos atributos evolutivos essenciais da humanidade, como criatividade, imaginação e associação, podem se tornar uma doença perigosa, abrigada nas sombras enevoadas da inteligência. (shrink)

In this work, we will approach some essential questions about the collective imaginary and their relations with reality and truth. We should face this subject in a conceptual framework, followed by the corresponding factual analysis of demonstrable behavioral realities. We will adopt not only the methodology, but mostly the tenets and propositions of the analytic philosophy, which certainly will be apparent throughout the study, and may be identified by the features described by Perez : -/- Rabossi (1975) defends the (...) idea that analytic philosophy can be identified by considering certain family resemblances. He suggests the following family traits: a positive attitude toward scientific knowledge; a cautious attitude toward metaphysics; a conception of philosophy as a conceptual task, which takes conceptual analysis as a method; a close relationship between language and philosophy; a concern with seeking argumentative answers to philosophical problems; search for conceptual clarity Perez, Diana Ines, "Analytic Philosophy in Latin America”, The Stanford Encyclopedia of Philosophy ). These core concepts involve cultural, social, religious, scientific, philosophic, moral, and political contents, belonging to the individual and collective existence of each one of us. The present work grounds itself on analytical reflection. We will speculate the most comprehensive and profound way we can and express the results of our thoughts. Notwithstanding the multidisciplinary nature of the subject and the methodological openness for accepting contributions from any field of science, this work belongs to the aim of psychology and ontology or, in other terms, social and ontological psychology. The main scope of this paper is to observe how some essential evolutionary attributes of humankind, like creativity, imagination, and association, can become a hazardous sickness, sheltered in the misty shadows of the intelligence. (shrink)

En el presente artículo se hace un recorrido por la idea de comunidada través de algunos pensadores contemporáneos que han tratado de repensar el estar en común asumiendo algunas de sus paradojas. Para autores como Roberto Esposito, Jean-Luc Nancy y Giorgio Agamben, pensar “la comunidad” implica reflexionarla a partir de las paradojas y contrasentidos que contiene, tanto anivel conceptual como a nivel de la realidad cotidiana. La paradoja central que resume tales contrasentidos es la que afirma que la comunidad (...) es realizable solo en la medida en que no lo es. Cercana a la paradoja de Russell, tal aporía nospermite reconocer la diferencia entre una comunidad que se hace cargo de sus contrasentidos e incoherencias, la comunidad de la crisis, y otra que al concebirse en términos unívocos y absolutos, es decir, que no se hace cargo de sus antinomias y contradicciones, nos lleva a lo que hemos llamado crisis de la comunidad. (shrink)

Critical notice of Roberto Polito, The Sceptical Road: Aenesidemus’ Appropriation of Heraclitus, Brill, Leiden and Boston, 2004; Brigitte Pérez-Jean, Dogmatisme et scepticisme: L’héraclitisme d’Énésidème, Presses Universitaires du Septentrion, Villeneuve d’Ascq, 2005.

En el presente trabajo nos hemos propuesto la factura de una exposición sucinta en torno a la crítica contra la metafísica clásica desde la perspectiva de Eduardo Nicol. Puede decirse que, desde el punto de vista de nuestro autor, la característica básica de la metafísica ha consistido en el soterramiento del ser, es decir, la metafísica clásica, de alguna u otra manera, ha versado acerca de un ser atemporal y oculto. El ocultamiento del ser ha estado íntimamente ligado al olvido (...) del tiempo y al endiosamiento de la razón; justo por esto Nicol se propone ahora una recuperación de la visibilidad del ser en aras de un contradiscurso del método. (shrink)

We investigate an expansion of quasi-MV algebras ([10]) by a genuine quantum unary operator. The variety of such quasi-MV algebras has a subquasivariety whose members—called cartesian—can be obtained in an appropriate way out of MV algebras. After showing that cartesian . quasi-MV algebras generate ,we prove a standard completeness theorem for w.r.t. an algebra over the complex numbers.

Contemporary scholarship concerning science diplomacy is increasingly taking a historical approach. In our introduction to this special issue, we argue that this approach promises insight into science diplomacy because of the tools historians of science bring to their work. In particular, we observe that not only are historians of science currently poised to chart the diplomatic aspects involved in the transnational circulation of technoscientific knowledge, materials, and expertise. They are ready to bring critical global analysis to an important phenomenon that (...) has too often been treated as a benign diplomacy device deployed by the Global North without equal reference to the Global South. Through cases discussed in the articles of the special issue, however, we see that historically, in the Global South as well as the Global North, science diplomacy has often functioned to mediate the circulation of technoscientific knowledge and materials, and its historical study helps to better illuminate the resulting knowledge-power nexus. (shrink)

Requiring family authorization for apnea testing subtracts health professionals control over death determination, a procedure that has traditionally been considered a matter of clinical expertise alone. In this commentary, we first provide evidence showing that health professionals’ (HPs) disposition to act on death determination without family’s prior consent could be much lower than that referred to by Berkowitz and Garrett (2020). We hypothesize that HPs may have reservations about their own expertise as regards death, and may thus hesitate to impose (...) their views on patients’ families. We then address the theoretical question of clinical expertise in death determination by distinguishing judgments about facts (e.g., the presence or absence of spontaneous breathing) from interpretations given of these facts (i.e., their meaning for the vital status of an individual). We argue that, while clinicians may claim some expert authority on the former, they hold no particular authority on the latter. (shrink)

The debate over the question whether quantum mechanics should be considered as a complete account of microphenomena has a long and deeply involved history, a turning point in which has been certainly the Einstein-Bohr debate, with the ensuing charge of incompleteness raised by the Einstein-Podolsky-Rosen argument. In quantum mechanics, physical systems can be prepared in pure states that nevertheless have in general positive dispersion for most physical quantities; hence in the EPR argument, the attention is focused on the question whether (...) the account of the microphysical phenomena provided by quantum mechanics is to be regarded as an exhaustive description of the physical reality to which those phenomena are supposed to refer, a question to which Einstein himself answered in the negative. However, there is a mathematical side of the completeness issue in quantum mechanics, namely the question whether the kind of states with positive dispersion can be represented as a different, dispersion-free kind of states in a way consistent with the mathematical constraints of the quantum mechanical formalism. From this point of view, the other source of the completeness issue in quantum mechanics is the no hidden variables theorem formulated by John von Neumann in his celebrated book on the mathematical foundations of quantum mechanics, the preface of which already anticipates the program and the conclusion concerning the possibility of ‘neutralizing’ the statistical character of quantum mechanics. (shrink)

Confirmation of a hypothesis by evidence can be measured by one of the so far known incremental measures of confirmation. As we show, incremental measures can be formally defined as the measures of confirmation satisfying a certain small set of basic conditions. Moreover, several kinds of incremental measure may be characterized on the basis of appropriate structural properties. In particular, we focus on the so-called Matthew properties: we introduce a family of six Matthew properties including the reverse Matthew effect; we (...) further prove that incremental measures endowed with reverse Matthew effect are possible; finally, we shortly consider the problem of the plausibility of Matthew properties. (shrink)

In this work I reconstruct the physical and mental descriptions of perception in Aristotle. I propose to consider the thesis that αἴσθησις is a μεσότης as a description of the physiological aspect of perception, meaning that perceiving is a physical act by which the sensory apparatus homeostatically counterbalances, and thence measures, the incoming affection produced by external perceptible objects. The proposal is based on a revision of the semantics of the word mesotês in Plato, Aristotle and later Greek mathematicians. I (...) show how this interpretation fits the text, and how it solves problems that afflict the rival interpretations. I further develop a ‘non-dephysiologizing’ spiritualist reading of the additional description of perception as reception of forms without the matter. I show that Aristotle uses the expression ‘forms without matter’ to describe actually abstracted items in one’s mind rather than the way in which the form are received. In opposition to forms-in-matter, such items are causally powerless and metaphysically sterile: an F-without-matter somewhat determines the subject it is in without qualifying or identifying it as an F-subject. Thus, we have a second ‘mental’ description of perception. Further parts of the thesis are devoted to settle interpretive questions raised by controversial statements about perception found in De Anima II 5 and III 2, and to discuss the question of how the mental and physiological descriptions of perception Aristotle offers are related. My conclusion is that Aristotle’s views combines a form of quasi-dualist vitalism about powers which is nonetheless compatible with hylomorphism, and a form of epiphenomenalism with regard to perceptual events. (shrink)

SummaryThe idea of interdisciplinarity can be articulated in different ways. The aim of the article is to criticise the view that interdisciplinarity is to be treated as a quality of the historian's approach to his subject-matter, and to argue for a constructivist interpretation of that notion. A constructivist account of interdisciplinarity relies on the thesis that the latter is one of the manifold ways in which it is possible to give sense to the historical records of which the historian wants (...) to gain knowledge. In the paper it is maintained that the function of the notion of interdisciplinarity is to account for the clash of languages that can be found when disciplines converge. This new paradigm is highlighted by taking into consideration the history of American pragmatism. (shrink)

The work of contemporary Italian thinkers, what Roberto Esposito refers to as Italian Theory, is attracting increasing attention around the world. This book explores the reasons for its growing popularity, its distinguishing traits, and why people are turning to these authors for answers to real-world issues and problems. The approach he takes, in line with the keen historical consciousness of Italian thinkers themselves, is a historical one. He offers insights into the great "unphilosophical" philosophers of life—poets, painters, politicians and (...) revolutionaries, film-makers and literary critics—who have made Italian thought, from its beginnings, an "impure" thought. People like Machiavelli, Croce, Gentile, and Gramsci were all compelled to fulfill important political roles in the societies of their times. No wonder they felt that the abstract vocabulary and concepts of pure philosophy were inadequate to express themselves. Similarly, artists such as Dante, Leonardo Da Vinci, Leopardi, or Pasolini all had to turn to other disciplines outside philosophy in order to discuss and grapple with the messy, constantly changing realities of their lives. For this very reason, says Esposito, because Italian thinkers have always been deeply engaged with the concrete reality of life and because they have looked for the answers of today in the origins of their own historical roots, Italian theory is a "living thought." Hence the relevance or actuality that it holds for us today. Continuing in this tradition, the work of Roberto Esposito is distinguished by its interdisciplinary breadth. In this book, he passes effortlessly from literary criticism to art history, through political history and philosophy, in an expository style that welcomes non-philosophers to engage in the most pressing problems of our times. As in all his works, Esposito is inclusive rather than exclusive; in being so, he celebrates the affirmative potency of life. (shrink)

Contents: List of Contributors VII; Roberto Poli: Foreword IX-X; Roberto Poli: The Brentano puzzle: an introduction 1; Dallas Willard: Who needs Brentano? The wasteland of philosophy without its past 15; Claire Ortiz Hill: Introduction to Paul Linke's 'Gottlob Frege as philosopher' 45; Paul F. Linke: Gottlob Frege as philosopher 49; John Blackmore: Franz Brentano and the University of Vienna Philosophical Society 1888-1938 73; Alf Zimmer: On agents and objects: some remarks on Brentanian perception 93; Liliana Albertazzi: Perceptual saliences (...) and nuclei of meaning 113; Jan Srzednicki: Brentano and the thinkable 139; Claire Ortiz Hill: From empirical psychology to phenomenology. Edmund Husserl on the 'Brentano puzzle' 151; Serena Cattaruzza: Brentano and Boltzmann: the Schubladenexperiment 169; Karl Schuhmann: Johannes Daubert's theory of judgement 179; Evelyn Dölling: On Alexius Meinong's theory of signs 199; Robin Rollinger: Linguistic expressions and acts of meaning: comments on Marty's philosophy of language 215-225. (shrink)

Alejandro offers a theoretical reflection on citizenship as a political category that could make possible a collective identity defined by the citizens' interpretations of traditions and their participation in the public sphere as well as their construction of a hermeneutic historical consciousness. This reflection seeks to pave the way for a vision of citizenship as a space of fluid boundaries within which there is room for diverse and even conflicting understandings of individuality, community, and public identity. Paper edition (unseen), $17.95. (...) Annotation c. by Book News, Inc., Portland, Or. (shrink)

O presente trabalho pretende discutir o conceito de história em Karl Marx a partir do confronto com a teoria do “fim da história” de Francis Fukuyama. No contexto histórico de queda do comunismo na União Soviética e no Leste Europeu, o autor americano introduz sua concepção sobre a vitória da democracia liberal como o momento culminante da história da humanidade. Pretendendo, assim, colocar-se como herdeiro de uma visão hegeliana da história. Ora, em que medida podemos considerar um sistema como o (...) defendido por Fukuyama como sendo o objetivo de toda a história da humanidade? Mais ainda, em que medida podemos considerar que há um objetivo na história da humanidade? Procuro mostrar como a concepção marxista da história responde a estas duas questões. (shrink)

Male-to-female transsexualism manifests itself in the form of a discrepancy between the male sex assigned at birth and the subjective experience of belonging to the female gender, which in many cases also involves a somatic transition by cross-sex hormone treatment and genital surgery. Until now, no studies related to MtF transsexualism have been carried out within the framework of a phenomenological/existential approach. This paradigm would make it possible to better articulate the transsexual experience beyond the simplistic diagnostic criteria by which (...) it is currently defined. In this study, I will reread MtF transsexualism in the light of Ludwig Binswanger’s theories on Mannerism and Jean Paul Sartre’s remarks on the self and the body. I will do this largely by focusing on first-hand accounts of the MtF transsexual’s experience, in other words from a first-person viewpoint. Finally, I will present some considerations on the meaning of psychological intervention in this field. (shrink)

This article discusses the controversy between Schelling and Eschenmayer regarding the Freiheitsschrift of 1809. Eschenmayer, a follower of the ideas of Jacobi, accuses Schelling of degrading God in applying to Him human concepts. Schelling, on the contrary, thinks that the faith needs the understanding.

El texto aborda, a manera de testimonio, el tema de la historia del Grupo de Bogotá –surgido en la Universidad Santo Tomás– y la Filosofía latinoamericana, en las décadas de 1970 y 1980, mediante el comentario de autores y textos que han hecho el análisis y la crítica del mismo grupo. Para hacerlo, se vale de las lecciones de verano de 1988, de Peter Sloterdijk, extraídas de su texto Venir al mundo venir al lenguaje, que aborda el tema del nacimiento (...) como una “poética del comenzar”. (shrink)

The book addresses the question of the alleged Heracliteanism of the Sceptic philosopher Aenesidemus of Cnossus.

Argle claimed that holes supervene on their material hosts, and that every truth about holes boils down to a truth about perforated things. This may well be right, assuming holes are perforations. But we still need an explicit theory of holes to do justice to the ordinary way of counting holes--or so says Cargle.

In this paper I offer a first account of a practice-based conception of normativity for the political domain. This standpoint is used to relocate the most sophisticated normative practices of justification and critique within an experience-based framework, that of the human being as a “normative creature.” I begin by discussing the two major paradigms in political theory, showing that their neglect of this broad framework of normativity is a serious drawback. I then proceed to articulate the central elements of a (...) practicebased account of normativity: the notions of normative practices and normative orders, and an account of the rationality potential of normativity as practice. (shrink)

Speciesism is a concept that was derived to name forms of discrimination and oppression against nonhuman animals that could be compared to racism and sexism. The concept was formulated in strong terms by Richard Ryder, Peter Singer, and Tom Regan that made it a powerful tool for social and political movements. The discourse on speciesism has been amplified and changed by a set of newer writings in the last few decades that take a more ethological, critical theory, and deconstructive bent. (...) This paper outlines some of the conditions for an antispeciesism based on posthumanism. As humanism itself is the most virulent form of speciesism, no robust antispeciesism can be developed without continued challenge to humanism. (shrink)