Supporting Hamilton’s inclusive fitness theory, archival analyses of inheritance patterns in wills have revealed that people invest more of their estates in kin of closer genetic relatedness. Recent classroom experiments have shown that this genetic relatedness effect is stronger for relatives of direct lineage (children, grandchildren) than for relatives of collateral lineage (siblings, nieces, nephews). In the present research, multilevel modeling of more than 1,000 British Columbian wills revealed a positive effect of genetic relatedness on proportions of estates allocated to (...) relatives. This effect was qualified by an interaction with lineage, such that it was stronger for direct than for collateral relatives. Exploratory analyses of the moderating role of benefactors’ sex and estate values showed the genetic relatedness effect was stronger among female and wealthier benefactors. The importance of these moderators to understanding kin investment in modern humans is discussed. (shrink)

We report the identification of a recurrent, 520-kb 16p12.1 microdeletion associated with childhood developmental delay. The microdeletion was detected in 20 of 11,873 cases compared with 2 of 8,540 controls and replicated in a second series of 22 of 9,254 cases compared with 6 of 6,299 controls. Most deletions were inherited, with carrier parents likely to manifest neuropsychiatric phenotypes compared to non-carrier parents. Probands were more likely to carry an additional large copy-number variant when compared to matched controls. The clinical (...) features of individuals with two mutations were distinct from and/or more severe than those of individuals carrying only the co-occurring mutation. Our data support a two-hit model in which the 16p12.1 microdeletion both predisposes to neuropsychiatric phenotypes as a single event and exacerbates neurodevelopmental phenotypes in association with other large deletions or duplications. Analysis of other microdeletions with variable expressivity indicates that this two-hit model might be more generally applicable to neuropsychiatric disease. © 2010 Nature America, Inc. All rights reserved. (shrink)

From the height of his ninety years of experience, Robert G. Shulman is not just a veteran of World War II, but a world-class biophysicist with a distinguished research career spanning the California Institute of Technology, Bell Labs, and Yale University. A forerunner in the use of nuclear magnetic resonance, Shulman contributed to the study of biochemical processes, founded the Yale Magnetic Resonance Research Center, and shepherded functional Magnetic Resonance Imaging (fMRI) as a dominant tool of cognitive neuroscience. Together with (...) Gregory McCarthy et al., Shulman authored several of the earliest fMRI studies, including the first to explicitly manipulate cognitive processes (McCarthy, Blamire, Rothman, Gruetter, & Shulman, 1993; Shulman, Blamire, Rothman, & McCarthy, 1993). As such, his ideas concerning conscious research piqued our curiosity. We read Brain Imaging: What It Can (and Cannot) Tell Us About Consciousness with anticipation.Shulman comes full circle with his book on brain imaging: although his career spanned meaningful collaborations with behavioural scientists and interactions with researchers from preclinical and clinical fields, he retreats to the comfort of the biophysical sciences. Two prominent, but related, hesitations give us pause regarding his retreat. First, he claims that a behaviourist approach to brain imaging is reasonable and pragmatic for the science of consciousness. Second, he rebuffs subjective and phenomenal forms of evidence. In... (shrink)

Gregory Currie defends the view that works of fiction guide the imagination, and then considers whether fiction can also guide our beliefs. He makes a case for modesty about learning from fiction, as it is easy to be too optimistic about the psychological insights of authors, and empathy is hard to acquire while not always morally advantageous.

The article examines the effects of non-financial disclosure on corporate social responsibility. We conceptualise trade-offs between two ideal types in relation to CSR. Whereas self-regulation is associated with greater flexibility for businesses to develop best practices, it can also lead to complacency if firms feel no external pressure to engage with CSR. In contrast, government regulation is associated with greater stringency around minimum standards, but can also result in rigidity owing to a ‘one-size-fits-all’ approach. Given these potential trade-offs, we ask (...) how mandatory non-financial disclosure has been shaping CSR practices and examine its potential effectiveness as a regulatory instrument. Our analysis of 24 OECD countries using the Asset4 database shows that firms in countries that require non-financial disclosure adopt significantly more CSR activities. However, we also find that NFD regulation does not lead to lower levels of corporate irresponsibility. Furthermore, our analysis demonstrates that, over time, the variation in CSR activities declines as firms adopt increasingly similar practices. Our study thereby contributes to understanding the impact of government regulation on CSR at firm level. We also discuss the limits of mandatory NFD in addressing regulatory trade-offs between stringency and flexibility in the field of corporate social responsibility. (shrink)

Philosophers have recently argued that self-fulfilling beliefs constitute an important counter-example to the widely accepted theses that we ought not and cannot believe at will. Cases of self-fulfilling belief are thought to constitute a special class where we enjoy the epistemic freedom to permissibly believe for pragmatic reasons, because whatever we choose to believe will end up true. In this paper, I argue that this view fails to distinguish between the aim of acquiring a true belief and the aim of (...) believing what is true. While one cannot usually fail to establish that one will acquire a true belief without establishing the truth of the believed proposition, in the case self-fulfilling belief the two can come apart. I argue that insofar as the aim of belief has to do with determining whether the believed proposition is true, it will be both impossible and impermissible to believe for pragmatic reasons. (shrink)

The field of of imprecise probability has matured, in no small part because of Teddy Seidenfeld’s decades of original scholarship and essential contributions to building and sustaining the ISIPTA community. Although the basic idea behind imprecise probability is (at least) 150 years old, a mature mathematical theory has only taken full form in the last 30 years. Interest in imprecise probability during this period has also grown, but many of the ideas that the mature theory serves can be difficult to (...) apprehend to those new to the subject. Although these fundamental ideas are common knowledge in the ISIPTA community, they are expressed, when they are expressed at all, obliquely, over the course of years with students and colleagues. -/- A single essay cannot convey the store of common knowledge from any research community, let alone the ISIPTA community. But, this essay nevertheless is an attempt to guide those familiar with the basic Bayesian framework to appreciate some of the elegant and powerful ideas that underpin the contemporary theory of lower previsions, which is the theory that most people associate with the term ‘imprecise probabilities’. (shrink)

This is the companion volume to Gregory Vlastos' highly acclaimed work Socrates: Ironist and Moral Philosopher. Four ground-breaking papers which laid the basis for his understanding of Socrates are collected here, in revised form: they examine Socrates' elenctic method of investigative argument, his disavowal of knowledge, his concern for definition, and the complications of his relationship with the Athenian democracy. The fifth chapter is a new and provocative discussion of Socrates' arguments in the Protagoras and Laches. The epilogue 'Socrates (...) and Vietnam' suggests that Socrates was not, as Plato claimed, the most just man of his time. The papers have been prepared for publication by Professor Myles Burnyeat with the minimum of editorial intervention. (shrink)

In this paper I consider the prospects for a skeptical version of infallibilism. For the reasons given above, I think skeptical invariantism has a lot going for it. However, a satisfactory theory of knowledge must account for all of our desiderata, including that our ordinary knowledge attributions are appropriate. This last part will not be easy for the infallibilist invariantist. Indeed, I will argue that it is much more difficult than those sympathetic to skepticism have acknowledged, as there are serious (...) problems with regarding paradigmatic, typical knowledge attributions as loose talk, exaggerations, or otherwise practical uses of language. So, I do not think the pragmatic story that skeptical invariantism needs is one that works without a supplemental error theory of the sort left aside by purely pragmatic accounts of knowledge attributions. In its place, I will offer a compromise pragmatic and error view that I think delivers everything that skeptics can reasonably hope to get. (shrink)

Catholic Social Teaching takes a rather cautious view toward the value of the ideas of Adam Smith, due to his emphasis on negative political and economic liberty. Detractors of Smith within CST point to what they consider to be deficiencies within his works: an impoverished moral anthropology, a lack of concern for the common good, and markets untethered to human needs. Defenders of Smith within CST tend to emphasize the material benefits that derive from Smithian institutions, such as economic growth, (...) improvements in standards of living, and the new opportunities that arise from cultures focused on innovation. This paper argues that Smith’s ideas have real value for CST. However, this value primarily lies in his moral psychology. While not denying the dangers of business activity for our moral lives, Smith also helps us to understand the possibility of the moral corruption of those who wield political power, thus providing an indirect defense of political and economic liberty that coheres with important Christian ethical notions found in CST. This is the case even though CST does not consistently recognize concerns surrounding the dangers of wielding political power—and thus Smith’s arguments offer real challenges to CST as well. This paper further suggests that these basic insights are relevant regardless of one’s favored institutional arrangements. (shrink)

That a philosophical thesis entails a vicious regress is commonly taken to be decisive evidence that the thesis is false. In this paper, I argue that the existence of a vicious regress is insufficient to reject a proposed analysis provided that certain constraints on the analysis are met. When a vicious regress is present, some further consequence of the thesis must be established that, together with the presence of the vicious regress, shows the thesis to be false. The argument is (...) provided largely through the examination of Michael Bergmann's vicious regress argument against strong awareness internalism and a partial defense of that thesis against Bergmann. (shrink)

This essay presents results about a deviation from independence measure called focused correlation . This measure explicates the formal relationship between probabilistic dependence of an evidence set and the incremental confirmation of a hypothesis, resolves a basic question underlying Peter Klein and Ted Warfield's ‘truth-conduciveness’ problem for Bayesian coherentism, and provides a qualified rebuttal to Erik Olsson's claim that there is no informative link between correlation and confirmation. The generality of the result is compared to recent programs in Bayesian epistemology (...) that attempt to link correlation and confirmation by utilizing a conditional evidential independence condition. Several properties of focused correlation are also highlighted. Introduction Correlation Measures 2.1 Standard covariance and correlation measures 2.2 The Wayne–Shogenji measure 2.3 Interpreting correlation measures 2.4 Correlation and evidential independence Focused Correlation Conclusion Appendix CiteULike Connotea Del.icio.us What's this? (shrink)

This paper considers the relationship between evidence and self-fulfilling beliefs. Following Grice (1971), many philosophers hold that adopting a self-fulfilling belief would involve an impermissible form of bootstrapping. I argue that such objections gets their force from a popular but problematic model of theoretical deliberation which pictures deliberation as a function, treating the deliberation’s inputs as given, fixed prior to and independently from the deliberation. Though such a picture may seem plausible, attending to the case of self-fulfilling beliefs can help (...) us see how such a function-model is inadequate for a general understanding of theoretical deliberation. Because it is unable to accommodate the possibility that the outcomes of our deliberation can sometimes be evidence for the proposition we are deliberating about, the function model is unable to account for cases where what we believe affects the truth of what is believed. (shrink)

Many philosophers think that part of what makes an event lucky concerns how probable that event is. In this paper, I argue that an epistemic probability account of luck successfully resists recent arguments that all theories of luck, including probability theories, are subject to counterexample (Hales 2016). I argue that an event is lucky if and only if it is significant and sufficiently improbable. An event is significant when, given some reflection, the subject would regard the event as significant, and (...) the event’s epistemic probability, determined by the subject’s evidence, is the only kind of probability that directly bears on whether or not the event is lucky. I conclude with some lessons that are applicable to probability theorists of luck generally, including those defending non-epistemic probability theories. (shrink)

This paper considers the relationship between evidence and self-fulfilling beliefs—beliefs whose propositional contents will be true just in case—and because—an agent believes them. Following Grice, many philosophers hold that believing such propositions would involve an impermissible form of bootstrapping. This paper argues that such objections get their force from a popular but problematic function-model of theoretical deliberation, and that attending to the case of self-fulfilling belief can help us see why such a model is mistaken. The paper shows that on (...) a revised model of theoretical deliberation our evidence will problematically underdetermine any appropriate doxastic attitude: when belief in a proposition is self-fulfilling, our evidence is insufficient to support belief, disbelief, or even suspended judgment toward that proposition. (shrink)

A half-billion years ago, a few species of single-celled protozoa stumbled irreversibly from loose social interaction into a tight, specialized interdependence. They became multi-celled metazoa, and human beings are one sort. Metazoa greatly transcend their constituent cells in lifetime, abilities, experiences and even materials (like bone). New kind of beings emerged out of the interactions of the old.

In his groundbreaking book, Against Coherence (2005), Erik Olsson presents an ingenious impossibility theorem that appears to show that there is no informative relationship between probabilistic measures of coherence and higher likelihood of truth. Although Olsson's result provides an important insight into probabilistic models of epistemological coherence, the scope of his negative result is more limited than generally appreciated. The key issue is the role conditional independence conditions play within the witness testimony model Olsson uses to establish his result. Olsson (...) maintains that his witness model yields charitable ceteris paribus conditions for any theory of probabilistic coherence. Not so. In fact, Olsson's model, like Bayesian witness models in general, selects a peculiar class of models that are in no way representative of the range of options available to coherence theorists. Recent positive results suggest that there is a way to develop a formal theory of coherence after all. Further, although Bayesian witness models are not conducive to the truth, they are conducive to reliability. (shrink)

In this chapter we draw connections between two seemingly opposing approaches to probability and statistics: evidential probability on the one hand and objective Bayesian epistemology on the other.

In this paper, I argue for the ethics of business based on the way that business activity may embody a vocation to partake in “the Good.” Following a Platonist framework for ethics and recent work on vocations by Robert M. Adams, I argue that understanding the ethics of vocations allows us to avoid the charges that business persons have to do something more for others—often couched in terms of social responsibility, sustainability, or consideration of stakeholders—in order to legitimize their careers (...) ethically. Rather, I claim, the ethics of a business vocation, as in any vocation, rests first and foremost in the way that a person pursues projects that answer an invitation to partake in the good things of this world. Thus, the promotion of the well-being of others, while ethically admirable and constitutive of some vocations, is not fundamental for understanding the ethics of vocations themselves, even in business. There are important implications for the ethics of markets, and I also consider a recent challenge to my approach that claims that true business vocations demand a more direct promotion of the well-being of others. (shrink)

In the age of big data and a machine epistemology that can anticipate, predict, and intervene on events in our lives, the problem once again is that a few individuals possess the knowledge of how to regulate these activities. But the question we face now is not how to share such knowledge more widely, but rather of how to enjoy the public benefits bestowed by this knowledge without freely sharing it. It is not merely personal privacy that is at stake (...) but a range of unsung benefits that come from ignorance and forgetting, traits that are inherently human and integral to the functioning of our society. (shrink)

In this paper, I explain the curious role played by the Argument from Absolute Terms in Peter Unger's book Ignorance, I provide a critical presentation of the argument, and I consider some outstanding issues and the argument’s contemporary significance.

Since 1995, students, researchers, and professionals have turned to The Craft of Research for clear and helpful guidance on how to conduct research and report it effectively. Now, master teachers Wayne C. Booth, Gregory G. Colomb, and Joseph M. Williams have completely revised and updated their classic handbook. The new edition will continue to help thousands of students and writers plan, carry out, and report on research to produce effective term papers, dissertations, articles, or books -- in any field, (...) at any level. (shrink)

We examine the notion of conditionals and the role of conditionals in inductive logics and arguments. We identify three mistakes commonly made in the study of, or motivation for, non-classical logics. A nonmonotonic consequence relation based on evidential probability is formulated. With respect to this acceptance relation some rules of inference of System P are unsound, and we propose refinements that hold in our framework.

The two envelope paradox can be dissolved by looking closely at the connection between conditional and unconditional expectation and by being careful when summing an infinite series of positive and negative terms. The two envelope paradox is not another St. Petersburg paradox and that one does not need to ban talk of infinite expectation values in order to dissolve it. The article ends by posing a new puzzle to do with infinite expectations.

The desirable gambles framework offers the most comprehensive foundations for the theory of lower pre- visions, which in turn affords the most general ac- count of imprecise probabilities. Nevertheless, for all its generality, the theory of lower previsions rests on the notion of linear utility. This commitment to linearity is clearest in the coherence axioms for sets of desirable gambles. This paper considers two routes to relaxing this commitment. The first preserves the additive structure of the desirable gambles framework and (...) the machinery for coherent inference but detaches the interpretation of desirability from the multiplicative scale invariance axiom. The second strays from the additive combination axiom to accommodate repeated gambles that return rewards by a non-stationary processes that is not necessarily additive. Unlike the first approach, which is a conservative amendment to the desirable gambles framework, the second is a rad- ical departure. Yet, common to both is a method for describing rewards called discounted utility. (shrink)

Ancient philosophical schools developed and discussed perspectives and practices on the emotion of anger useful in contemporary philosophical practice with clients, groups, and organizations. This paper argues the case for incorporating these insights from four main philosophical schools (Platonist, Aristotelian, Epicurean, and Stoic) sets out eight practices drawn from these schools, and discusses how these insights can be used by philosophical practitioners with clients.

Spengler’s work is typically represented as speculative philosophy of history. However, I argue that there is good reason to consider much of his thought as preoccupied with existential and phenomenological questions about the nature and ends of human existence, rather than with history per se. In this paper I consider Spengler’s work in comparison with Heidegger’s history of Being and analysis of technological modernity. I argue that Spengler’s considerable proximity to much of Heidegger’s thought compels us to reconsider the nature (...) and scope of Spengler’s philosophical project. (shrink)

Positions in the debate about the correct semantics of “S knows that p” are sometimes motivated in part by an appeal to interpretive charity. In particular, non-skeptical views hold that many utterances of the sentence “S knows that p” are true and some of them think the fact that their views are able to respect this is a reason why their views are more charitable than skeptical invariantism. However, little attention has been paid to why charity should be understood in (...) this way and little effort has been spent justifying the notion that a charitable semantics is likely to be true. I distinguish two kinds of interpretive charity. One principle of charity is often appealed to in the literature. I introduce a second. I argue that while some positions better respect one principle of charity, the reverse is true of the other principle of charity. I conclude with some remarks about how to break this apparent tie. (shrink)

Henry Kyburg’s lottery paradox (1961, p. 197) arises from considering a fair 1000 ticket lottery that has exactly one winning ticket. If this much is known about the execution of the lottery it is therefore rational to accept that one ticket will win. Suppose that an event is very likely if the probability of its occurring is greater than 0.99. On these grounds it is presumed rational to accept the proposition that ticket 1 of the lottery will not win. Since (...) the lottery is fair, it is rational to accept that ticket 2 won’t win either—indeed, it is rational to accept for any individual ticket i of the lottery that ticket i will not win. However, accepting that ticket 1 won’t win, accepting that ticket 2 won’t win, . . . , and accepting that ticket 1000 won’t win entails that it is rational to accept that no ticket will win, which entails that it is rational to accept the contradictory proposition that one ticket wins and no ticket wins. (shrink)

Logic is a celebrated representation language because of its formal generality. But there are two senses in which a logic may be considered general, one that concerns a technical ability to discriminate between different types of individuals, and another that concerns constitutive norms for reasoning as such. This essay embraces the former, permutation-invariance conception of logic and rejects the latter, Fregean conception of logic. The question of how to apply logic under this pure invariantist view is addressed, and a methodology (...) is given. The pure invariantist view is contrasted with logical pluralism, and a methodology for applied logic is demonstrated in remarks on a variety of issues concerning non-monotonic logic and non-monotonic inference, including Charles Morgan’s impossibility results for non-monotonic logic, David Makinson’s normative constraints for non-monotonic inference, and Igor Douven and Timothy Williamson’s proposed formal constraints on rational acceptance. (shrink)

This paper presents statistical default logic, an expansion of classical (i.e., Reiter) default logic that allows us to model common inference patterns found in standard inferential statistics, including hypothesis testing and the estimation of a populations mean, variance and proportions. The logic replaces classical defaults with ordered pairs consisting of a Reiter default in the first coordinate and a real number within the unit interval in the second coordinate. This real number represents an upper-bound limit on the probability of accepting (...) the consequent of an applied default and that consequent being false. A method for constructing extensions is then defined that preserves this upper bound on the probability of error under a (skeptical) non-monotonic consequence relation. (shrink)

Many philosophers of science have argued that a set of evidence that is "coherent" confirms a hypothesis which explains such coherence. In this paper, we examine the relationships between probabilistic models of all three of these concepts: coherence, confirmation, and explanation. For coherence, we consider Shogenji's measure of association (deviation from independence). For confirmation, we consider several measures in the literature, and for explanation, we turn to Causal Bayes Nets and resort to causal structure and its constraint on probability. All (...) else equal, we show that focused correlation, which is the ratio of the coherence of evidence and the coherence of the evidence conditional on a hypothesis, tracks confirmation. We then show that the causal structure of the evidence and hypothesis can put strong constraints on how coherence in the evidence does or does not translate into confirmation of the hypothesis. (shrink)

Information-based epistemology maintains that ‘being informed’ is an independent cognitive state that cannot be reduced to knowledge or to belief, and the modal logic KTB has been proposed as a model. But what distinguishes the KTB analysis of ‘being informed’, the Brouwersche schema (B), is precisely its downfall, for no logic of information should include (B) and, more generally, no epistemic logic should include (B), either.

SETTING: Previous health policies in South Africa neglected the teaching of ethics and human rights to health professionals. In April 1995, a pilot course was run at the University of Cape Town in which the ethical dimensions of human rights issues in South Africa were explored. OBJECTIVES: To compare knowledge and attitudes of participating students with a group of control students. DESIGN: Retrospective cohort study. SUBJECTS: Seventeen fourth-year medical students who participated in the course and 13 control students from the (...) same class, matched for gender. INTERVENTIONS: Students participated in a one-week module on ethics and human rights. Five months after the course had been run, students completed a semi-structured questionnaire exploring their knowledge and attitudes with regards to ethics and human rights issues. MAIN OUTCOME MEASURES: Knowledge scores, attitude scores and various individual indicators of attitude. RESULTS: Clear benefits for overall knowledge score, for four out of five individual knowledge questions and for one of the attitude questions, were demonstrated. Participating students also appeared to be more convinced of the need for teaching on the ethical dimensions of human rights at postgraduate level and that such teaching should also be integrated in the curriculum. The low response rate amongst controls may have selected students who were more socially conscious, thereby leading to an underestimate of the true impact of the course. CONCLUSION: The evaluation indicates clear benefits of the course for undergraduate students, and supports arguments for the inclusion of such courses in the training of health professionals. This is particularly important given the challenges posed by the Truth and Reconciliation Commission to the health professions to address past complicity in human rights abuses through reorientation of medical training in South Africa. (shrink)

Andrew Arato. Seyla Benhabib. Hauke Brunkhorst. Cornelius Castoriadis. Jean Cohen. Helmut Dubiel. Klaus Eder. Gunter Frankenberg. Hans-Georg Gadamer. Axel Honneth. Johann Baptist Metz. Gertrud Nunner-Winkler. Claus Offe.".

We discuss mathematical and physical arguments against continuity and in favor of discreteness, with particular emphasis on the ideas of Émile Borel.