Global Cumulative Treatment Analysis is a novel clinical research model combining expert knowledge, and treatment coordination based upon global information-gain, to treat every patient optimally while efficiently searching the vast space that is the realm of cancer research.

Science is a form of distributed analysis involving both individual work that produces new knowledge and collaborative work to exchange information with the larger community. There are many particular ways in which individual and community can interact in science, and it is difficult to assess how efficient these are, and what the best way might be to support them. This paper reports on a series of experiments in this area and a prototype implementation using a research platform called CACHE. CACHE (...) both supports experimentation with different structures of interaction between individual and community cognition and serves as a prototype for computational support for those structures. We particularly focus on CACHE‐BC, the Bayes community version of CACHE, within which the community can break up analytical tasks into “mind‐sized” units and use provenance tracking to keep track of the relationship between these units. (shrink)

Programming languages are, at the same time, instruments and communicative artifacts that evolve rapidly through use. In this paper I describe an online computing platform called BioBike. BioBike is a trading zone where biologists and programmers collaborate in the development of an extended vocabulary and functionality for computational genomics. In the course of this work they develop interactional expertise with one another’s domains. The extended BioBike vocabulary operates on two planes: as a working programming language, and as a pidgin in (...) the conversation between the biologists and engineers. The flexibility that permits this community to dynamically extend BioBike’s working vocabulary—to form new pidgins—makes BioBike unique among computational tools, which usually are not themselves adapted through the collaborations that they facilitate. Thus BioBike is itself a crucial feature—which it is tempting to refer to as a participant—in the developing interaction.Keywords: Trading zones; Collaboration; Interactional expertise; Genomics; Computer programming languages; Lisp. (shrink)

“Hypernormal science” has minimal potential for contestation on matters of principle and practice so that information exchange can be unproblematic. Sciences comprise hypernormal domains and more contestable “normal” domains where knowledge diffusion, like acquiring linguistic fluency, depends on face-to-face interaction. Hypernormal domains belonging to molecular biology are contrasted with normal domains in gravitational wave detection physics. Sciences as a whole should not be confused with their typical domains. The analysis has immediate implications for proposed transitions out of the Covid-19 lockdown, (...) proposed solutions to the replication crisis, and, perhaps, our understanding of the early development of social studies of science. (shrink)

The key question in this three way debate is the role of the collectivity and of agency. Collins and Shrager debate whether cognitive psychology has, like the sociology of knowledge, always taken the mind to extend beyond the individual. They agree that irrespective of the history, socialization is key to understanding the mind and that this is compatible with Clark’s position; the novelty in Clark’s “extended mind” position appears to be the role of the material rather than the role (...) of other minds. Collins and Clark debate the relationship between self, agency, and the human collectivity. Collins argues that the Clark’s extended mind fails to stress the asymmetry of the relationship between the self and its material “scaffolding.” Clark accepts that there is asymmetry but that an asymmetrical ensemble is sufficient to explain the self. Collins says that we know too little about the material world to pursue such a model to the exclusion of other approaches including that both the collectivity and language have agency. The collectivity must be kept in mind! (Though what follows is a robust exchange of views it is also a cooperative effort, authors communicating “backstage” with each other to try to make the disagreements as clear and to the point as possible.). (shrink)

On the face of it, the directors of new large scientific projects have an impossible task. They have to make technical decisions about sciences in which they have never made a research contribution—sciences in which they have no contributory expertise. Furthermore, these decisions must be accepted and respected by the scientists who are making research contributions. The problem is discussed in two interviews conducted with two directors of large scientific projects. The paradox is resolved for the managers by their use (...) of interactional and referred expertise. The same analysis might be applicable to management in general. An Appendix, co-authored with Jeff Shrager, compares the notion of referred expertise with contributory expertise.Keywords: Management; Referred expertise; Interactional expertise; LIGO; Thirty Meter Telescope; Big science. (shrink)

An important issue in epistemology concerns the source of epistemic normativity. Epistemic consequentialism maintains that epistemic norms are genuine norms in virtue of the way in which they are conducive to epistemic value, whatever epistemic value may be. So, for example, the epistemic consequentialist might say that it is a norm that beliefs should be consistent, in that holding consistent beliefs is the best way to achieve the epistemic value of accuracy. Thus epistemic consequentialism is structurally similar to the family (...) of consequentialist views in ethics. Recently, philosophers from both formal epistemology and traditional epistemology have shown interest in such a view. In formal epistemology, there has been particular interest in thinking of epistemology as a kind of decision theory where instead of maximizing expected utility one maximizes expected epistemic utility. In traditional epistemology, there has been particular interest in various forms of reliabilism about justification and whether such views are analogous to—and so face similar problems to—versions of consequentialism in ethics. This volume presents some of the most recent work on these topics as well as others related to epistemic consequentialism, by authors that are sympathetic to the view and those who are critical of it. (shrink)

In this paper, we present three necessary conditions for morally responsible animal research that we believe people on both sides of this debate can accept. Specifically, we argue that, even if human beings have higher moral status than nonhuman animals, animal research is morally permissible only if it satisfies (a) an expectation of sufficient net benefit, (b) a worthwhile-life condition, and (c) a no unnecessary-harm/qualified-basic-needs condition. We then claim that, whether or not these necessary conditions are jointly sufficient conditions of (...) justified animal research, they are relatively demanding with the consequence that many animal experiments may fail to satisfy them. (shrink)

Progress in psychology and the cognitive sciences is often taken to vindicate physicalism and cast doubt on such extravagant metaphysical theses as dualism and idealism. The goal of this paper is to argue that cognitive science has no such implications—rather, evidence from cognitive science is largely (but not wholly) irrelevant to the mind-body problem. Our argument begins with the observation that data from cognitive science can be modeled by supervenience relations. We then show that supervenience relations are neutral, by showing (...) how they can be coherently interpreted in physicalist, idealist, and dualist terms. We distinguish several types of supervenience relation, and show that each coheres better with some positions on the mind-body problem than the other. Since these variants of supervenience are not empirically equivalent, there is a possibility that data from cognitive science will end up supporting some positions on the mind-body problem more than others. It is in this sense that cognitive science is mostly, but not wholly, neutral. (shrink)

This paper corrects three widely held misunderstandings about Maxent when used in common sense reasoning: That it is language dependent; That it produces objective facts; That it subsumes, and so is at least as untenable as, the paradox-ridden Principle of Insufficient Reason.

The article argues that historical materialism is not only a theory of historical change but more generally a mediation between the natural foundations of human life and its meaningful symbolic expressions. The article begins with an interpretation of the general philosophical significance of the basic premises of historical materialism as they are sketched in the German Ideology. I argue that these premises point us in two different directions: down, towards a scientific understanding of the natural world, and up, towards interpretations (...) of meaningful human expressions. Reductionist scientific models are appropriate for the understanding of natural forces, but these reveal their own limitations when applied to social life. Social life cannot be understood outside its symbolic expressions, but these are not free floating ideal abstractions, but remain connected to fundamental human purposes and must be understood as such. (shrink)

In his Nobel Prize acceptance speech in 1987, the Russian-born American poet Joseph Brodsky argued that aesthetics is the mother of ethics. However, there is an ambiguity in his use of the term aesthetics. In the first part of this article, I distinguish between Brodsky’s narrow use of aesthetics, which refers to problems of beauty, and the broader sense, which refers to the cognitive function of sensibility and feeling. I then suggest that good sense can be made of the claim (...) about the origins of ethics only if we employ the broader sense of aesthetics. The second part draws on examples from Brodsky and the American poet Jorie Graham to illustrate the ways in which the feelings generated by human sensuous receptivity transform the world from a meaningless physical system into meaningful sets of life-valuable relationships. The third part sharpens this conclusion by considering the conditions under which the world can appear to be meaningless. In the final section I link Brodsky’s poetic responsiveness to the world to John McMurtry’s philosophical analysis of “the felt side of being.” Poetic evocation and philosophical argument are two approaches to the same problem which, when brought together, provide a comprehensive explanation of why aesthetics is the mother of ethics. (shrink)

Journal of Social Philosophy, EarlyView.

Dussel’s complex work calls into question the standard history of philosophy, reveals a counter-history at work beneath the official history that gives voice to the victims of capitalism and colonialism, and systematically develops a novel ‘material ethics’ grounded in an unqualified, universal affirmation of life as the foundation of liberatory values. The Ethics of Liberation brings together the major problems explored in Dussel’s prolific body of earlier work: the relationship between Western philosophy and the expansion of European society; the relationship (...) between centre and periphery in global political economy, considered as both a philosophical and an ethical problem; the ethical interpretation of Marxism; the politics of liberation in the colonial context; the defence of universal foundations of ethical norms; and the distinction between formal and critical ethics. (shrink)

Human life is finite. Given that lifetime is necessarily limited, the experience of time in any given society is a central ethical problem. If all or most of human lifetime is consumed by routine tasks then human beings are dominated by the socially determined experience of time. This article first examines time as the fundamental existential framework of human life. It then goes on to explore the determination of time today by the ruling value system that underlies advanced capitalist society. (...) It concludes that the equation ‘time is money’ rules the contemporary experience of time, and goes on to argue that this experience deprives those who live under this ruling value system of a central requirement of free human life: the experience of time as an open matrix of possibilities for action. (shrink)

Volume 25, Issue 7-8, November - December 2020, Page 880-881.

Volume 24, Issue 3-4, May - June 2019, Page 437-445.

Volume 25, Issue 2, February - March 2020, Page 217-224.

(1999). Subjecthood and Self-Determination: The Limitations of Postmodernism as Democratic Theory. Canadian Journal of Philosophy: Vol. 29, Supplementary Volume 25: Civilization and Oppression, pp. 147-169.

At different times Horkheimer, Adorno, and Marcuse argued that immortality is a condition of overcoming misery and achieving complete human freedom. Their arguments were made before “practical immortality” had become a concrete scientific project. The difference between what was then and what is now scientifically possible alters the ethical and political value of the idea of immortality. Had the first generation of critical theorists occupied the present historical moment, they would have realized that science harnessed to the demand for limitless (...) life would not solve the kind of ethical and existential problems they hoped it would. I argue that the scientific struggle against human finitude is driven by the same egocentric concern for money and self-maximization that early critical theory diagnosed as the main psychological pathology caused by capitalism. Finitude, I conclude, is the price human beings must pay if they are to live free and meaningful lives. (shrink)

This essay focuses on the purported duty—defended by Walter Benjamin but widely assumed in much political theory and practice—of the living to redeem the suffering of those who died as a consequence of oppression, exploitation, and political violence. I consider the cogency and ethical value of this duty from the perspective of a politics grounded in the equal life-value of human beings. For both metaphysical and ethical reasons I conclude that this duty does not obtain, first because the dead cannot (...) experience redemption, and secondly because it is politically counterproductive: it personalizes a pathological form of political resistance which may easily incite further violence and thus perpetuate human suffering and oppression. (shrink)

The European Legacy, Volume 17, Issue 5, Page 704-705, August 2012.

An essay exploring the failure of the Freethought Movement to repell the Religious Right in American politics.

Key Enlightenment minds are often juxtaposed with their iconic foes, religious conservatives. When discussing the subject of women’s rights, however, this comparison creates a false impression that Enlightenment male thinkers held ideas very much opposed to a dogmatic institution such as the Catholic Church. Ironically, and damaging to their legacy of prejudice-free rationalism, nearly all of the philosophes, many of whom were “freethinking” atheists, viewed woman’s intellectual nature and societal purpose through a prejudice-tainted glass, not unlike the most conservative establishments (...) of their time. Indeed, when it came to the perception of women, the philosophes had less in common with a virulently secular feminist such as Nicholas de Caritat, marquis de Condorcet, than they do with modern conservative Christians who believe women should be treated more fairly, but still cling to gender stereotypes. (shrink)

This paper will examine the loss of confidence in secular bases for the normative understanding of, and response to, the fundamental social and political problems. The recent arguments of Richard Falk in favour of a religious foundation for a humane globalization will be taken as paradigmatic. While the paper agrees that the normative core of major world religions supports Falk's particular conclusion that religion can provide the content for a universal critique of inhumane global governance, it will conclude that the (...) universal claim that global human solidarity today can only be built on the basis of religious faith does not follow. The paper will contend that the required normative foundation for the positive project of constructing global human solidarity is neither religious nor secular, but synthetic, embracing both—in what I will call, following the work of John McMurtry—the “life-ground of value.”. (shrink)

The article features an analytic protocol for examining controversial criminal cases in critical thinking courses. The rubric has been designed to be useful to busy critical thinking teachers who wish to draw on student interest in true crime. Six guidelines are presented that are intended to provide the instructor with a convenient scheme for quickly and easily framing classroom discussions. Due to their generality, the guidelines can be readily applied to a wide-range of cases, giving educators a high degree of (...) flexibility in the selection of criminal affairs. (shrink)

Heidegger scholars consider the philosopher's recently published notebooks, including the issues of Heidegger's Nazism and anti-Semitism. For more than forty years, the philosopher Martin Heidegger logged ideas and opinions in a series of notebooks, known as the “Black Notebooks” after the black oilcloth booklets into which he first transcribed his thoughts. In 2014, the notebooks from 1931 to 1941 were published, sparking immediate controversy. It has long been acknowledged that Heidegger was an enthusiastic supporter of the Nazi Party in the (...) early 1930s. But the notebooks contain a number of anti-Semitic passages—often referring to the stereotype of “World-Jewry”—written even after Heidegger became disenchanted with the Nazis themselves. Reactions from the scholarly community have ranged from dismissal of the significance of these passages to claims that the anti-Semitism in them contaminates all of Heidegger's work. This volume offers the first collection of responses by Heidegger scholars to the publication of the notebooks. In essays commissioned especially for the book, the contributors offer a wide range of views, addressing not only the issues of anti-Semitism and Nazism but also the broader questions that the notebooks raise. Contributors Babette Babich, Andrew Bowie, Steven Crowell, Fred Dallmayr, Donatella Di Cesare, Michael Fagenblat, Ingo Farin, Gregory Fried, Jean Grondin, Karsten Harries, Laurence Paul Hemming, Jeff Malpas, Thomas Rohkrämer, Tracy B. Strong, Peter Trawny, Daniela Vallega-Neu, Friedrich-Wilhelm von Herrmann, Nancy A. Weston, Holger Zaborowski. (shrink)