Cell signalling mediators derived from membrane phospholipids are frequent participants in biological processes. The family of phosphoinositide 3-kinases (PI3Ks) phosphorylate the membrane lipid phosphatidylinositol, generating second messengers that direct diverse responses. These PI3K products are fundamental for leukocyte migration or chemotaxis, a pivotal event during the immune response. This system is therefore of significant biomedical interest. This review focuses on the biochemistry and signalling pathways of PI3K, with particular emphasis on chemokine (chemotactic cytokine)-directed responses. The key objectives of chemotaxis are (...) motility and direction. The latter—direction—requires distinct events at the front and back of a cell. In light of this, the coordinated localisation of signalling factors, an event choreographed by a sharp intracellular gradient of PI3K-derived products, is a common theme. BioEssays 27:153–163, 2005. © 2005 Wiley Periodicals, Inc. (shrink)

The ongoing ‘enhancement’ debate pits critics of new self-shaping technologies against enthusiasts. One important thread of that debate concerns medicalization, the process whereby ‘non-medical’ problems become framed as ‘medical’ problems.In this paper I consider the charge of medicalization, which critics often level at new forms of technological self-shaping, and explain how that charge can illuminate – and obfuscate. Then, more briefly, I examine the charge of pharmacological Calvinism, which enthusiasts, in their support of technological self-shaping, often level at critics. And (...) I suggest how that charge, too, can illuminate and obfuscate.Exploring the broad charge of medicalization and the narrower counter charge of pharmacological Calvinism leads me to conclude that, as satisfying as it can be to level one of those charges at our intellectual opponents, and as tempting as it is to lie down and rest with our favorite insight, we need to gather the energy to have a conversation about the difference between good and bad forms of medicalization. Specifically, I suggest that if we consider the ‘medicalization of love,’ we can see why critics of and enthusiasts about technological self-shaping should want (and in some cases have already begun) to distinguish between good and bad forms of such medicalization. (shrink)

Beginning with the assumptions that genetic technology will make possible the enhancement of some significant human capacities and that our society will have self-evident reasons to pursue such enhancements, this essay suggests less evident reasons to proceed with extreme caution. The essay asks: Will we, in our attempts to enhance humans by reducing their subjection to chance and change, inadvertently impoverish them? It explores how technologies aimed at enhancement might affect the good that is our experience of some forms of (...) the beautiful and the excellent, the good that is relationships of care, and the good that is diversity across the life span. In the end, it speculates about the fundamental philosophical difference that underlies the disagreement between those who would tend to embrace a project to enhance human capacities and those who would tend to criticize such a project. (shrink)

A measure of coherence is said to be truth conducive if and only if a higher degree of coherence (as measured) results in a higher likelihood of truth. Recent impossibility results strongly indicate that there are no (non-trivial) probabilistic coherence measures that are truth conducive. Indeed, this holds even if truth conduciveness is understood in a weak ceteris paribus sense (Bovens & Hartmann, 2003, Bayesian epistemology. New York, Oxford: Oxford University Press; Olsson, 2005, Against coherence: Truth probability and justification. Oxford: (...) Oxford University Press). This raises the problem of how coherence could nonetheless be an epistemically important property. Our proposal is that coherence may be linked in a certain way to reliability. We define a measure of coherence to be reliability conducive if and only if a higher degree of coherence (as measured) results in a higher probability that the information sources are reliable. Restricting ourselves to the most basic case, we investigate which coherence measures in the literature are reliability conducive. It turns out that, while a number of measures fail to be reliability conducive, except possibly in a trivial and uninteresting sense, Shogenji’s measure and several measures generated by Douven and Meijs’s recipe are notable exceptions to this rule. (shrink)

Jonathan Cohen has claimed that in cases of witness agreement there is an inverse relationship between the prior probability and the posterior probability of what is being agreed: the posterior rises as the prior falls. As is demonstrated in this paper, this contention is not generally valid. In fact, in the most straightforward case exactly the opposite is true: a lower prior also means a lower posterior. This notwithstanding, there is a grain of truth to what Cohen is saying, as (...) there are special circumstances under which a thesis similar to his holds good. What characterises these circumstances is that they allow for the fact of agreement to be surprising. In making this precise, I draw on Paul Horwich's probabilistic analysis of surprise. I also consider a related claim made by Cohen concerning the effect of lowering the prior on the strength of corroboration. 1 Introduction 2 Cohen's claim 3 A counterexample 4 A weaker claim 5 A counterexample to the weaker claim 6 The grain of truth in Cohen's claim 7 Prior probability and strength of corroboration 8 Conclusion. (shrink)

In this article we move beyond the problematic distinction between ‘higher’ and ‘lower’ cognition by accounting for so-called ‘higher’ cognitive capacities in terms of skillful activities in practices, and in terms of the affordances exploited in those practices. Through ethnographic research we aim to further develop the new notion of skilled intentionality by turning to the phenomenon of the tendency towards an optimal grip on a situation in real-life situations in the field of architecture. Tending towards an optimal grip is (...) an inherently affective and dynamic phenomenon. It has been under explored in philosophy, despite its central place in Merleau-Ponty’s phenomenology. When the architects experience discontent, attention is typically solicited by the affordances through which possible ways of continuing the improvement of the design can be explored. In various ways this tension or disequilibrium - fueling a tendency towards an optimal grip - is encountered in the complex architectural design practices that we observed. Based on our field material we distinguish between: a) grip in visual perception, b) grip on the design, and c) grip on ‘how to design’. The move towards an optimal grip takes shape by joining forces with a landscape of affordances. This landscape includes, for instance, affordances for grasping a cup of coffee, affordances provided by a cardboard model to improve it, as well as for engaging with a person who is not physically present. Because they are skilled, the architects can be responsive to these different affordances in similar ways. Furthermore, in practice the architects are responsive to multiple affordances simultaneously. Through our analysis of the tendency towards an optimal grip we show that our surroundings contribute to skillful action and cognition in a far more complex way than is currently acknowledged in philosophy and cognitive science. (shrink)

Neutral monism is a position in metaphysics defended by Mach, James, and Russell in the early twentieth century. It holds that minds and physical objects are essentially two different orderings of the same underlying neutral elements of nature. This paper sets out some of the central concepts, theses and the historical background of ideas that inform this doctrine of elements. The discussion begins with the classic neutral monism of Mach, James, and Russell in the first part of the paper, then (...) considers recent neo-Russellian versions in the second half. The chances for a revival of neutral monism are probably slight; its key ideas and starting points lie far from those in contemporary philosophy of mind. A better route might be through the philosophy of science and a deeper understanding of causation. (shrink)

During antiquity, the astronomical questions of the day and the methods used to formulate and answer them were clearly within the realm of philosophy. That changed most notably in the sixteenth century when Tycho Brahe turned astronomy into a modern empirical science by formulating (in principle) testable hypotheses, figuring out how to test them, building the proper instruments, and making – for that time – very accurate and systematic observations of the sky. These observations eventually led to the modern view (...) of the solar system and ultimately the rejection of the classical Aristotelian worldview. Since then, the exploration of space has been located clearly in the realm of natural science – and, to an increasing extent, technology. In parallel to that, space has – at least since World War II –to a high degree been a place for military and political ambitions and activities. The scientists that have been involved in space exploration have mainly been physicists, together with some chemists and geologists. Lately, the exploration of space has engaged more and more biologists in the search for extraterrestrial life. The international space station, along with plans to send humans to Mars, has led to an increased involvement of medical science. If present speculations about space tourism and mining on planets, moons, and asteroids hold true, in the future we will probably see many new professions dealing not just with exploration, but also exploitation of space. Philosophy has never totally left the realm of space exploration. As space exploration and exploitation become more and more interdisciplinary, and as space becomes a bigger part of our lives, it will be time once more for philosophy to turn its attention towards space. The mission for philosophers is not to indulge in speculations over questions that are better dealt with by empirical methods. Ther are, however, several questions connected to the exploration and exploitation of space that are of a philosophical nature and that deserve to be examined seriously from a philosophical perspective. I believe that philosophical scrutiny of these questions will be to the benefit of both space exploration and philosophy. Interesting and, indeed, important philosophical questions arise in many areas of space exploration. Some of the most interesting and important ones relate to the search for extraterrestrial life, of which some will be presented here. I will not attempt to answer these questions here. Instead, this chapter should be seen as an introduction to some of the philosophical questions raised by astrobiology. (shrink)

"In these essays, health care professionals, scholars, and members of the disability community debate the implications of prenatal testing for people with disabilitties and for parent-child relationships generally."--Cover.

A principal aim of the branch of ethics called ‘population theory’ or ‘population ethics’ is to find a plausible welfarist axiology, capable of comparing total outcomes with respect to value. This has proved an exceedingly difficult task. In this paper I shall state and discuss two ‘trilemmas’, or choices between three unappealing alternatives, which the population ethicist must face. The first trilemma is not new. It originates with Derek Parfit's well-known ‘Mere Addition Paradox’, and was first explicitly stated by Yew-Kwang (...) Ng. I shall argue that one horn of this trilemma is less unattractive than Parfit and others have claimed. The second trilemma, which is a kind of mirror image of the first, appears hitherto to have gone unnoticed. Apart from attempting to resolve the two trilemmas, I shall suggest certain features which I believe a plausible welfarist axiology should possess. The details of this projected axiology will, however, be left open. (shrink)

While color realism is endorsed, Byrne & Hilbert's (B&H's) case for it stretches the notion of “physical property” beyond acceptable bounds. It is argued that a satisfactory account of color should do much more to respond to antirealist intuitions that flow from the specificity of color experience, and a pointer to an approach that does so is provided.

We reply to Christoph Jäger's criticism of the conditional probability solution (CPS) to the value problem for reliabilism due to Goldman and Olsson (2009). We argue that while Jäger raises some legitimate concerns about the compatibility of CPS with externalist epistemology, his objections do not in the end reduce the plausibility of that solution.

I examine the debate between substantivalists and relationalists about the ontological character of spacetime and conclude it is not well posed. I argue that the hole argument does not bear on the debate, because it provides no clear criterion to distinguish the positions. I propose two such precise criteria and construct separate arguments based on each to yield contrary conclusions, one supportive of something like relationalism and the other of something like substantivalism. The lesson is that one must fix an (...) investigative context in order to make such criteria precise, but different investigative contexts yield inconsistent results. I examine questions of existence about spacetime structures other than the spacetime manifold itself to argue that it is more fruitful to focus on pragmatic issues of physicality, a notion that lends itself to several different explications, all of philosophical interest, none privileged a priori over any of the others. I conclude by suggesting an extension of the lessons of my arguments to the broader debate between realists and instrumentalists. 1 Introduction2 The Hole Argument3 Limits of Spacetimes4 Pointless Constructions5 The Debate between Substantivalists and Relationalists6 Existence and Physicality: An Embarassment of Spacetime Structures7 Valedictory Remarks on Realism and Instrumentalism, and the Structure of Our Knowledge of Physics. (shrink)

Subjective measures of well-being—measures based on answers to questions such as ‘Taking things all together, how would you say things are these days—would you say you're very happy, pretty happy, or not too happy these days?’—are often presented as superior to more traditional economic welfare measures, e.g., for public policy purposes. This paper aims to spell out and assess what I will call the argument from directness: the notion that subjective measures of well-being better represent well-being than economic measures do (...) because subjective measures (and subjective measures alone) are direct measures of well-being. My main thesis is that the argument begs the question against proponents of economic measures: it is based on a premise that they reject and that is no less in need of justification than the conclusion of the argument, namely, the proposition that well-being is constituted by subjectively experienced mental states. If subjective measures can be defended as valid measures of well-being at all, I will maintain, it is because they are (imperfect) indirect measures of well-being. (shrink)

According to the so?called swamping problem, reliabilist knowledge is no more valuable than mere true belief. In a paper called ?Reliabilism and the value of knowledge? (in Epistemic value, edited by A. Haddock, A. Millar, and D. H. Pritchard, pp. 19?41. Oxford: Oxford University Press, 2009), Alvin I. Goldman and myself proposed, among other things, a solution based on conditional probabilities. This approach, however, is heavily criticized by Jonathan L. Kvanvig in his paper ?The swamping problem redux: Pith and gist? (...) (in Social Epistemology, edited by A. Haddock, A. Millar, and D. H. Pritchard, pp. 89?111. Oxford: Oxford University Press, 2010). In the present article, I defend the conditional probability solution against Kvanvig?s objections. (shrink)

This study is a contribution to the bioethical debate about new and possibly emerging reproductive technologies. Its point of departure is the intuition, which many people seem to share, that using such technologies to select non-disease traits – like sex and emotional stability - in yet unborn children is morally problematic, at least more so than using the technologies to avoid giving birth to children with severe genetic diseases, or attempting to shape the non-disease traits of already existing children by (...) environmental means, like education. The study employs philosophical analysis for the purpose of making this intuition intelligible and judging whether it is justified. Different ways in which the moral problems posed by reproductive technologies are often framed in bioethical debates are criticised as inadequate for this task. In particular, it is argued that the intuition cannot fully be made sense of in terms of harm to the children that such technologies help create. The study attempts to elaborate an alternative to that broadly consequentialist approach, by drawing on Martin Heidegger’s philosophy of technology, Hans Jonas’s ethics, and Aristotle’s practical philosophy, as it has been received and developed in the hermeneutical tradition. It is suggested that reproductive choices, unlike decisions for already born children, are characterised by a peculiar one-sidedness: the future child appears to the parents as something wholly theirs to decide about, not as a concrete other with whom they must interact in a responsive and attuned way. This is problematic because it means that such choices cannot call upon the particularised moral understanding only gained in interpersonal encounters. In particular, it makes them easily shaped by various tendencies, to which parents are always susceptible, to relate to children in instrumentalising ways, and at risk of reinforcing such tendencies. However, this does not mean that all uses of reproductive technologies are equally troubling. When selecting against severe disease the parents can rely on a widely shared illness experience to escape the dangers that one-sidedness involves. It is concluded that the intuition under discussion, thus explicated and in some ways qualified, makes sense morally. (shrink)

In the current literature on scientific explanation unification became unfashionable in favour of causal approaches. We want to bring unification back into the picture. In this paper we demonstrate that resemblance questions do occur in scientific practice and that they cannot be properly answered without unification. Our examples show that resemblance questions about particular facts demand what we call causal network unification, while resemblance questions about regularities require what we call mechanism unification. We clarify how these types of unification relate (...) to Philip Kitcher’s account, but also to causal and mechanistic accounts of explanation. (shrink)

For more than 20 years, sustainable development has been advocated as a way of tackling growing global environmental and social problems. The sustainable development discourse has always had a strong technological component and the literature boasts an enormous amount of debate on which technologies should be developed and employed and how this can most efficiently be done. The mainstream discourse in sustainable development argues for an eco-efficiency approach in which a technology push strategy boosts efficiency levels by a factor 10 (...) and more in industrialised and developing countries. A minority argues for a socio-cultural lifestyle switch, relying on new values, quality of life, sufficiency and redistribution strategies, with calls for appropriate and soft technologies. It is remarkable, however, that the articles, books and policy debates on sustainability seldom explicitly draw in a discussion of the nature of technology, how technology influences and is influenced by society, and what this implies for sustainable development. The mainstream interprets technology as neutral and instrumental: technology is no more than an instrument to reach a goal; it cannot be judged on its intrinsic characteristics, only on its use. The alternative view often builds on an autonomous and substantive interpretation of technology: technology is an autonomous, almost uncontrollable power that fundamentally reshapes our culture. A more balanced approach seems to be growing in the research on socio-technical sustainability transitions where the focus shifts to the co-evolution of technology and society, and to the networks, seamless webs and complex multi-actor processes that may carry a sustainability transition forward. This approach builds on insights from recent traditions in the philosophy and sociology of technology, in particular the social construction of technology (SCOT) and actor-network theory (ANT). While this provides for a better understanding of the nature and potential role of technology in sustainability policies, it remains to be seen whether it will actually influence the choice between technologies. This article investigates the different conceptualisations of technology in the sustainability debate. It first distinguishes between different approaches of sustainability and how these are related to differing views on technology. It then moves on to how the socio-technical transitions research incorporates insights from contemporary philosophy and sociology of technology. It reflects on the potential of transitions research to give guidance in technology choices, suggesting that the transition approach might be strengthened by drawing in insights from critical theory of technology and by taking a more political stance in defining sustainable development. (shrink)

In this paper we discuss three interrelated questions. First: is explanation in mathematics a topic that philosophers of mathematics can legitimately investigate? Second: are the specific aims that philosophers of mathematical explanation set themselves legitimate? Finally: are the models of explanation developed by philosophers of science useful tools for philosophers of mathematical explanation? We argue that the answer to all these questions is positive. Our views are completely opposite to the views that Mark Zelcer has put forward recently. Throughout this (...) paper, we show why Zelcer’s arguments fail. (shrink)

This paper examines the notion of “subjective well-being” as it is used in literature on subjective measures of well-being. I argue that those who employ the notion differ at least superficially on at least two points: first, about the relationship between subjective well-being and well-being simpliciter, and second, about the constituents of subjective well-being. In an effort to reconcile the differences, I propose an interpretation according to which subjective measures presuppose preference hedonism: an account according to which well-being is a (...) matter of desired mental states. (shrink)

In many contexts a retraction of commitment isfrowned upon. For instance, it is not appreciated,generally, if one withdraws a promise or denies anearlier statement. Critical discussion, too, caneasily be disrupted by retractions, if these occur toofrequently and at critical points. But on the otherhand, the very goal of critical discussion –resolution of a dispute – involves a retraction,either of doubt, or of some expressed point of view.A person who never retracts, not even under pressureof cogent arguments, would hardly qualify as (...) areasonable discussant. Also, inconsistencies in one'sposition, once they have been pointed out, must bedealt with by some kind of retraction. The problem ofretraction is to find a suitable model of dialoguethat allows retractions where they seem reasonable, oreven required, and rules them out (or puts sanctionsupon them) whenever they would become disruptive of awell-organized process of dialogue.The present paper tries to point to a solution basedon the following principles: (1) Retraction rulesdetermine what retractions are permissible, and (2) ifpermissible what the consequences of retraction are.(3) Retraction rules vary according to the type ofdialogue and (4) according to the type of commitmentretracted. For instance, assertions and mereconcessions need to be distinguished, as well aslight-side and dark-side commitments. (5) To accountfor our contradictory intuitions on the issue ofretractions, one may best resort to a complex type ofdialogue in which different retraction rules hold fordifferent parts.The paper explains, summarizes, and expands upon thediscussion of retraction in Commitment inDialogue by Douglas Walton and the present author(cf. Walton and Krabbe 1995). (shrink)

ABSTRACTUnquestionably, philosophy has acquired a somewhat new register lately. First, I discuss the appearance of the theological virtues in contemporary philosophy. This appearance is heralded in Nietzsche’s famous preface to The Gay Science. The event remains at this point curious and without explanation. In a second step, I explore current French philosophy and culture as the frame and/or the effect of this appearance. At this point, I still cannot find the philosophical meaning of the virtues, only the condition of possibility (...) of their ‘extra-theological’ relevance. At most, I can reopen the religious nature, element or register of thought, of philosophy. I will do that by introducing eschatology and desecularisation, implying that modern rationalist allegedly areligious atheism is actually a hyper-religious theism. Desecularisation can only be understood within the frame of an ‘open world’, within a world-as-opening. World then becomes the event of meaning and the thought that thinks the opening, open thought as it were, is philosophical charity or philosophy-as-charity. The effect of all this is precisely philosophy turning into virtuous thought. Philosophy becomes, in ‘fact’, hope, faith and charity. (shrink)

The question of the existence of gravitational stress-energy in general relativity has exercised investigators in the field since the inception of the theory. Folklore has it that no adequate definition of a localized gravitational stress-energetic quantity can be given. Most arguments to that effect invoke one version or another of the Principle of Equivalence. I argue that not only are such arguments of necessity vague and hand-waving but, worse, are beside the point and do not address the heart of the (...) issue. Based on a novel analysis of what it may mean for one tensor to depend in the proper way on another, which, en passant, provides a precise characterization of the idea of a "geometric object", I prove that, under certain natural conditions, there can be no tensor whose interpretation could be that it represents gravitational stress-energy in general relativity. It follows that gravitational energy, such as it is in general relativity, is necessarily non-local. Along the way, I prove a result of some interest in own right about the structure of the associated jet bundles of the bundle of Lorentz metrics over spacetime. I conclude by showing that my results also imply that, under a few natural conditions, the Einstein field equation is the unique equation relating gravitational phenomena to spatiotemporal structure, and discuss how this relates to the non-localizability of gravitational stress-energy. (shrink)

Stuart White argues that egalitarians need a diverse toolkit of policy proposals in order to move closer to a just economic system. In particular he argues that a policy of Basic Capital grants should be included in this toolkit along with a variety of other more familiar instruments such as unconditional Basic Income, welfare state services and income supports, and support for worker cooperatives. The various policies in the egalitarian toolkit, however, have implications for issues other than contributing to a (...) more just economic system. In particular, they have implications for the long term stability, transformation, or even transcendence, of capitalism as an economic system. In this article I will argue that unconditional Basic Income has a greater potential to erode capitalism than does Basic Capital. While both of these policies in the egalitarian toolkit may make the economic system statically more just, over time Basic Capital grants are likely to strengthen capitalism as the core structure of the economic system, whereas unconditional Basic Income has the potential to erode the dominance of capitalism. As part of a long-term project of human emancipation, therefore, unconditional Basic Income should have priority over Basic Capital. (shrink)

Chapter Introduction The field of artificial intelligence is concerned with the construction of computer systems which exhibit intelligent behavior in order ...

William Bateson has long occupied a controversial role in the history of biology at the turn of the twentieth century. For the most part, Bateson has been situated as the British translator of Mendel or as the outspoken antagonist of W. F. R. Weldon and Karl Pearson's biometrics program. Less has been made of Bateson's transition from embryologist to advocate for discontinuous variation, and the precise role of British and American influences in that transition, in the years leading up to (...) the publication of his massive Materials for the Study of Variation. In this paper, I first attempt to trace Bateson's development in his early career before turning to search for the development of the moniker "anti-Darwinist" that has been attached to Bateson in well-known histories of the neo-Darwinian Synthesis. (shrink)

Many countries are now implementing human papillomavirus vaccination. There is disagreement about who should receive the vaccine. Some propose vaccinating both boys and girls in order to achieve the largest possible public health impact. Others regard this approach as too costly and claim that only girls should be vaccinated. We question the assumption that decisions about human papillomavirus vaccination policy should rely solely on estimates of overall benefits and costs. There are important social justice aspects that also need to be (...) considered. Policy makers should consider how to best protect individuals who will remain unvaccinated through no fault of their own. This is especially important if these individuals are already disadvantaged in other ways and if vaccinating other people increases their risk of infection. (shrink)

The aim of this investigation is to answer the question of why it is prima facie morally wrong to cause or contribute to the extinction of species. The first potential answer investigated in the book is that other species are instrumentally valuable for human beings. The results of this part of the investigation are that many species are instrumentally valuable for human beings but that not all species are equally valuable in all cases. The instrumental values of different species also (...) have to compete with other human values. Sometimes these other values probably outweigh the value of the continued existence of the species. In general the degree of uncertainty is very high and the precautionaty principle is recommended to deal with these uncertainties. We also found that we have a duty to consider the interests of future generations of human beings and that these duties, in general, speak in favour of preservation. Anthropocentric instrumentalism therefore provides us with rather strong reasons to consider many cases of human caused extinction as prima facie morally wrong. Even so, anthropocentric instrumentalism does not fully account for the moral intuition we set out to investigate. The next potential answer that is investigated in the book is that species have a moral standing in their own right. The result of this part of the investigation is that this idea is highly unlikely, in particular because species cannot have any interests to consider. Anotgher potential answer is that species have intrinsic value in some other meaning that does not imply moral standing. We concluded that it is possible to be subjectively valued as an end and that many species have properties that make them highly suitable for being valued as ends by human beings. Finally, we found that our contributions to the extinction of species in most cases frustrate the interests of many non-human sentient beings. This is true if the species in question is made up of sentient individuals, and it is also true when the species in question is made up of non-sentient individuals that have instrumental value for sentient individuals of other species. There are exceptions to this rule, but all in all it seems that the inclusion of non-human sentient individuals together with us humans as moral objects, in most cases, tip the scale drastically in favour of preservation. The main result of the investigation is that there is not one but several explanations to why it is prima facie morally wrong to contribute to the extinction of species – and all of them are about duties to respect the interests of individual sentient animals, including human beings. (shrink)

If we eventually discover extraterrestrial life, do we have any moral obligations for how to treat the life-forms we find; does it matter whether they are intelligent, sentient, or just microbial—and does it matter that they are extraterrestrial? -/- In this paper, I examine these questions by looking at two of the basic questions in moral philosophy: What does it take to be a moral object? and What has value of what kind? I will start with the first of these (...) questions by looking at the most important attempts to answer this question on our own planet and by asking whether and how they could be applied to extraterrestrial life. The results range from a very strong protection of all extraterrestrial life and all extraterrestrial environments, whether inhabited or not, to total exclusion of extraterrestrial life. Subsequently, I also examine whether extraterrestrial life that lacks moral status can have value to human or alien life with moral status, and if that could generate any obligations for how to treat extraterrestrial life. Based on this analysis, I conclude that extraterrestrial life-forms can have both instrumental value and end value to moral objects, which has strong implications for how to treat them. (shrink)

Isaac Levi has claimed that our reliance on the testimony of others, and on the testimony of the senses, commonly produces inconsistency in our set of full beliefs. This happens if what is reported is inconsistent with what we believe to be the case. Drawing on a conception of the role of beliefs in inquiry going back to Dewey, Levi has maintained that the inconsistent belief corpus is a state of ``epistemic hell'': it is useless as a basis for inquiry (...) and deliberation. As he has also noticed, the compatibility of these two elements of his pragmatist epistemology could be called into question. For if inconsistency means hell, how can it ever be rational to enter that state, and on what basis could we attempt to regain consistency? Levi, nonetheless, has tried to show that the conflict is only apparent and that no changes of his theory are necessary. In the main part of the paper I argue, by contrast, that his attempts to reconcile these components of his view are unsuccessful.The conflict is real andthus presents a genuine threat to Deweyan pragmatism, as understood by Levi. After an attempt to pinpoint exactly where the source of the problem lies, I explore some possibilities for how to come to grips with it. I conclude that Levi can keep his fundamental thesis concerning the role of beliefs in inquiry and deliberation, provided that he (i) gives up the view that the agent can legitimately escape from inconsistency, and (ii) modifies his account of prediction alias deliberate expansion by acknowledging a third desideratum, besides probability and informational value, namely, not to cause permanent breakdown further down the line of inquiry. The result is a position which is more similar to Peter Gärdenfors's than is Levi's original theory, while retaining the basic insights of the latter. (shrink)

A new foundation for constructive nonstandard analysis is presented. It is based on an extension of a sheaf-theoretic model of nonstandard arithmetic due to I. Moerdijk. The model consists of representable sheaves over a site of filter bases. Nonstandard characterisations of various notions from analysis are obtained: modes of convergence, uniform continuity and differentiability, and some topological notions. We also obtain some additional results about the model. As in the classical case, the order type of the nonstandard natural numbers is (...) a dense set of copies of the integers. Every standard set has a hyperfinite enumeration of its standard elements in the model. All arguments are carried out within a constructive and predicative metatheory: Martin-Löf's type theory. (shrink)

We aim to further develop and evaluate the prospects of a uniquely Islamic extension of the Standard Aquinas/Calvin model. One obstacle is that certain Qur’an passages such as Surah 8:43–44 apparently suggest that Muslims have reason to think that Allah might be deceiving them. Consistent with perfect/maximally good being theology, Allah would allow such deceptions only if doing so leads to a greater good, so such passages do not necessarily give Muslims reason to doubt Allah’s goodness. Yet the possibility of (...) deception of the faithful threatens to provide a subjective defeater for the (epistemic) reliability of their cognitive faculties. (‘Even if Allah can be morally good while deceiving, how do you know you aren’t being deceived for a greater good on a more macro level, such as about the nature of the Qur’an?’) Similar in structure to Alvin Plantinga’s Evolutionary Argument Against Naturalism (EAAN), this defeater threatens to undermine all of a Muslims warrant claims. We consider and evaluate the reply that there are other Qur’anic passages and/or additional conceptual resources in the Islamic tradition that provide grounds for thinking that God’s faithfulness or truthfulness is more centrally and securely embedded in a Muslim’s noetic structure than such doubts. Specifically, we will argue that under certain conditions, there exists a subjective defeater for some Muslims that, unlike McNabb’s approach, isn’t based off of the proper function condition but Plantinga’s truth aimed condition. (shrink)

If we find life on another world, it will be an extremely important discovery and we will have to take great care not to do anything that might endanger that life. If the life we find is sentient we will have moral obligations to that life. Whether it is sentient or not, we have a duty to ourselves to preserve it as a study object, and also because it would be commonly seen as valuable in its own right. In addition (...) to this we would also have a duty to our fellow humans and other earthly life forms not to expose them to danger by advertently or inadvertently exposing them to potentially harmful space organisms. When space exploration turns into exploitation it will therefore be important to be able to show that a world that is up for exploitation is uninhabited before the exploitation starts. Showing that a world is uninhabited is, however, a different kind of task than showing that it is inhabited. The latter task can be accomplished through one positive finding but it is not clear how to go about the former task. In this paper I suggest that it is a gradual process asymptotically approaching certainty rather than a discovery in the traditional sense of the word. It has to be handled in two steps. The first is to connect degree of certainty with research setup. The second is to decide how certain we need to be. The first step is about the number, diversity and quality of observations. The second step is a decision we have to make based on the purpose of the investigation. The purpose and therefore the degree of certainty needed to establish that a world is uninhabited will be different for a world that is up for exploitation than for a world that is not. In the latter case it is only a matter of epistemic values. In the former case also ethical values have to be considered. (shrink)