SummaryHeterozygous 4.1 hereditary elliptocytosis results from the absence of one haploid set of protein 4.1, a major component of the red cell skeleton. Two successive epidemiological investigations revealed fifteen probands in the French Northern Alps. The frequency of this disease seems to be very high in four small villages isolated in the Aravis mountains. The genealogical study shows that eleven probands share common ancestors who lived eight or ten generations ago in these villages. Thus there was probably a founder effect (...) from one pair of ancestors, strengthened by endogamy. In contrast, four probands originate from another area and are not genealogically related. Recent results in molecular genetics support the present data. (shrink)

How do thought and language manage to be 'about' aspects of the world? J. Robert G. Williams investigates how representation arises out of a fundamentally non-representational world, showing the explanatory relations between the representational properties of language, of thought, and of perception and intention.

A new way to transpose the virtue epistemologist’s ‘knowledge = apt belief’ template to the collective level, as a thesis about group knowledge, is developed. In particular, it is shown how specifically judgmental belief can be realised at the collective level in a way that is structurally analogous, on a telic theory of epistemic normativity (e.g., Sosa 2020), to how it is realised at the individual level—viz., through a (collective) intentional attempt to get it right aptly (whether p) by alethically (...) affirming that p. An advantage of the proposal developed is that it is shown to be compatible with competing views—viz., joint acceptance accounts and social-distributive accounts—of how group members must interact in order to materially realise a group belief. I conclude by showing how the proposed judgment-focused collective (telic) virtue epistemology has important advantages over a rival version of collective virtue epistemology defended in recent work by Jesper Kallestrup (2016). (shrink)

Strange inversions occur when things work in ways that turn received wisdom upside down. Hume offered a strangely inverted story about causation, and Darwin, about apparent design. Dennett suggests that a strange inversion also occurs when we project our own reactive complexes outward, painting our world with elusive properties like cuteness, sweetness, blueness, sexiness, funniness, and more. Such properties strike us as experiential causes, but they are really effects—a kind of shorthand for whole sets of reactive dispositions rooted in the (...) nuts and bolts of human information processing. Understanding the nature and origins of that strange inversion, Dennett believes, is thus key to understanding the nature and origins of human experience itself. This paper examines this claim, paying special attention to recent formulations that link that strange inversion to the emerging vision of the brain as a Bayesian estimator, constantly seeking to predict the unfolding sensory barrage. (shrink)

The meta-problem is 'the problem of explaining why we think that there is a problem of consciousness' (Chalmers, 2018, p. 6). This presupposes that we think there is a problem in the first place. We challenge the breadth of this 'we', arguing that there is already sufficient empirical evidence to cast doubt on the claim. We then add to this body of evidence, presenting the results of a new cross-cultural study extending the work of Sytsma and Machery (2010).

The conservation of energy and momentum have been viewed as undermining Cartesian mental causation since the 1690s. Modern discussions of the topic tend to use mid-nineteenth century physics, neglecting both locality and Noether’s theorem and its converse. The relevance of General Relativity has rarely been considered. But a few authors have proposed that the non-localizability of gravitational energy and consequent lack of physically meaningful local conservation laws answers the conservation objection to mental causation: conservation already fails in GR, so there (...) is nothing for minds to violate. This paper is motivated by two ideas. First, one might take seriously the fact that GR formally has an infinity of rigid symmetries of the action and hence, by Noether’s first theorem, an infinity of conserved energies-momenta. Second, Sean Carroll has asked how one should modify the Dirac–Maxwell–Einstein equations to describe mental causation. This paper uses the generalized Bianchi identities to show that General Relativity tends to exclude, not facilitate, such Cartesian mental causation. In the simplest case, Cartesian mental influence must be spatio-temporally constant, and hence 0. The difficulty may diminish for more complicated models. Its persuasiveness is also affected by larger world-view considerations. The new general relativistic objection provides some support for realism about gravitational energy-momentum in GR. Such realism also might help to answer an objection to theories of causation involving conserved quantities, because energies-momenta would be conserved even in GR. (shrink)

Autonomous Knowledge: Radical Enhancement, Autonomy, and the Future of Knowing motivates and develops a new research programme in epistemology that is centred around the concept of epistemic autonomy.

A change in sense of self is an outcome commonly associated with Buddhist meditation. However, the sense of self is construed in multiple ways, and which changes in self-related processing are expected, intended, or possible through meditation is not well understood. In a qualitative study of meditation-related challenges, six discrete changes in sense of self were reported by Buddhist meditators: change in narrative self, loss of sense of ownership, loss of sense of agency, change in sense of embodiment, change in (...) self-other or self-world boundaries, and loss of sense of basic self. Changes in sense of self could be transient or enduring, positive or distressing, enhancing or impairing. These changes were also given varied appraisals, ranging from insights associated with Buddhist doctrines to psychopathologies such as depersonalization. In this study of practitioners reporting meditation-related challenges, more global changes in sense of self were associated with higher levels of impairment. These results have implications for both Buddhist meditation as well as mindfulness-based interventions. (shrink)

ABSTRACTThe seminal work of David Marr, popularized in his classic work Vision, continues to exert a major influence on both cognitive science and philosophy. The interpretation of his work also co...

In the paper, the originator of the hiddenness argument, J. L. Schellenberg, responds to papers that challenge his reasoning. In his remarks he puts an emphasis on the concept of divine love and he explains why it is not only connected to the idea of the Christian God. He also clarifies his position on ultimism.

Here I reply to criticisms by Jeroen de Ridder and S. Kate Devitt to my "Collective (Telic) Virtue Epistemology".

Conceptual clarity is essential when engaging in dialogue to avoid unnecessary disagreement and to promote mutual understanding. In this issue devoted to clinical bioethics, the authors exemplify the virtue of careful conceptual analysis as they explore complex clinical questions regarding the essential nature of medicine, the boundaries of killing and letting die, the meaning of irreversibility in definitions of death, the argument for a right to try experimental medications, the ethical borders in complex medical billing, and the definition and modeling (...) of complex disease states. (shrink)

Minimally, metaphysical realists hold that there exist some mind-independent entities. Metaphysical realists also hold that we can speak meaningfully or truthfully about mind-independent entities. Those who reject metaphysical realism deny one or more of these commitments. This Element aims to introduce the reader to the core commitments of metaphysical realism and to illustrate how these commitments have changed over time by surveying some of the main families of views that realism has been contrasted with: such as scepticism, idealism, and anti-realism.

Everyone interested in Arabic and Persian literature, in Islam and in comparative religion, regrets the death of Arthur J. Arberry, Sir Thomas Adams's Professor of Arabic in the University of Cambridge. Arberry combined rare human qualities and exceptional professional attainment, and this enabled him to make a unique contribution both to learning and to mutual understanding between East and West. He had a deep sense of vocation, which he brought to his unremitting labours as a skilled editor of texts, especially (...) in the field of Islamic mysticism, and as an imaginative translator of these texts of the Koran and of Arabic and Persian poetry, and as a sympathetic interpreter of Sūfism. (shrink)

Why is there a 'hard problem' of consciousness? Why do we seem unable to grasp intuitively that physical brain processes can be identical to experiences? Here I comment on the 'meta-problem' (Chalmers, 2018), based on previous ideas (Storm, 2014; 2018). In short: humans may be 'inborn dualists' ('neuroscepticism'), because evolution gave us two (types of) brain systems (or functional modes): one (Sp) for understanding relatively simple physical phenomena, and another (Sm) specialized for mental phenomena. Because Sp cannot deal with the (...) immense complexity of the brain processes underlying consciousness, it represents them as fundamentally different from nonmental physical phenomena (dualist intuition), using 'simulations' to produce 'Sm-type understanding'/predictions that seems radically different from 'Sp-type understanding'. (By analogy, different sensory modalities, handled by distinct brain systems, evoke qualitatively different experiences.) Brain systems for Sp representations of our brain processes never evolved, because they would be useless. When lacking a single 'template' matching different aspects of reality (objective vs. subjective = simulated), complementary 'models' are needed ('neuro-complementarity'), like the wave–particle duality in quantum mechanics. Thus, it seems plausible that Sp and Sm evolved because they were needed to cope with different challenges, and that 'problem intuitions' are side effects of these useful but different brain systems. (shrink)

Semantic Scholar extracted view of "Animal Welfare and Rights: V. Zoos and Zoological Parks" by J. Dunlap et al.

This 2002 volume brings together major works by German thinkers, writing just prior to and after Kant, who were enormously influential in this crucial period of aesthetics. These texts include the first translation into English of Schiller's Kallias Letters and Moritz's On the Artistic Imitation of the Beautiful, together with translations of some of Hölderlin's most important theoretical writings and works by Hamann, Lessing, Novalis and Schlegel. In a philosophical introduction J. M. Bernstein traces the development of aesthetics from its (...) still rationalist and mimetic construction in Lessing, through the optimistic construal of art and/or beauty as the appearance of human freedom in the work of Schiller, to Hölderlin's darker vision of art as the memory of a lost unity, and the variations of that theme - of an impossible striving after the lost ideal - which are found in the work of Schlegel and Novalis. (shrink)

This paper critically evaluates an objection to introspective arguments for human freedom found within Spinoza's Ethics. The objection-- which we call Spinoza's dream argument -- challenges the evidentiary value of a person's experience of her own freedom by pointing out that some choices made within dreams are experienced as no less free than choices made while awake despite the fact that choices made within dreams are not free. After reconstructing Spinoza's dream argument, we critically evaluate it, concluding ultimately that it (...) fails in two respects. First, we draw upon the results of an experiment we conducted that suggests that dreamt choices are not experienced as free to the same extent as choices made while awake. Second, we argue that there is no compelling justification for the claim that choices made within dreams are not free. (shrink)

Literature on testimonial injustice and ways that perpetrators might combat it have flourished since Miranda Fricker’s ground-breaking work on testimonial injustice. Less attention has been given, however, to the role of bystanders. In this paper, I examine the accountability that bystanders may have for their omissions to redress testimonial injustice. I argue that bystander accountability applies in cases where it is opportune for bystanders to intervene, and if they are also sufficiently equipped and able to redress the testimonial injustice. Moreover, (...) I recommend that we move beyond virtue responsibilism for ameliorative thinking about testimonial injustice. (shrink)

In this provocative work, J. L. Schellenberg addresses those who, influenced by science, take a negative view of religion, thinking of it as outmoded if not decadent. He promotes the view that transcendently oriented religion is developmentally immature, showing the consilience of scientific thinking about deep time with his view. From this unique perspective, he responds to a number of influential cultural factors commonly thought to spell ill for religion, showing the changes – changes favorable to religion – that are (...) now called for in how we understand them and their proper impact. Finally, he provides a defense for a new and attractive religious humanism that benefits from, rather than being hindered by, religious immaturity. In Schellenberg's view, religion can and should become a human project as monumental as science. (shrink)

Principles of expert deference say that you should align your credences with those of an expert. This expert could be your doctor, the objective chances, or your future self, after you've learnt something new. These kinds of principles face difficulties in cases in which you are uncertain of the truth-conditions of the thoughts in which you invest credence, as well as cases in which the thoughts have different truth-conditions for you and the expert. For instance, you shouldn't defer to your (...) doctor by aligning your credence in the de se thought 'I am sick' with the doctor's credence in that same de se thought. Here, I generalise principles of expert deference to handle these kinds of problem cases. (shrink)

J. O. Urmson; VIII*—A Defence of Intuitionism, Proceedings of the Aristotelian Society, Volume 75, Issue 1, 1 June 1975, Pages 111–120, https://doi.org/10.1093/.

According to Humean theories of objective chance, the chances reduce to patterns in the history of occurrent events, such as frequencies. According to non-Humean accounts, the chances are metaphysically fundamental, existing independently of the "Humean Mosaic" of actually-occurring events. It is therefore possible, by the lights of non-Humeanism, for the chances and the frequencies to diverge wildly. Humeans often allege that this undermines the ability of non-Humean accounts of chance to rationalize adherence to David Lewis' Principal Principle (PP), which states (...) that an agent's degrees of belief should match what they take to be the objective chances. In this paper, I propose two approaches to justifying (PP) for non-Humean chance, hence defusing the Humean objection. The first approach justifies (PP) via the role it plays in informing outright beliefs about long-run frequencies. The second approach justifies (PP) by showing that adherence to (PP), even for non-Humean chance, maximizes expected epistemic utility according to the actual objective chance function. I then address an objection to this approach, concerning the alleged circularity of the derivations. (shrink)

J. L. Mackie; XIII—The Possibility of Innate Knowledge, Proceedings of the Aristotelian Society, Volume 70, Issue 1, 1 June 1970, Pages 245–260, https://doi.org.