The Ontology for Biomedical Investigations (OBI) is an ontology that provides terms with precisely defined meanings to describe all aspects of how investigations in the biological and medical domains are conducted. OBI re-uses ontologies that provide a representation of biomedical knowledge from the Open Biological and Biomedical Ontologies (OBO) project and adds the ability to describe how this knowledge was derived. We here describe the state of OBI and several applications that are using it, such as adding semantic expressivity to (...) existing databases, building data entry forms, and enabling interoperability between knowledge resources. OBI covers all phases of the investigation process, such as planning, execution and reporting. It represents information and material entities that participate in these processes, as well as roles and functions. Prior to OBI, it was not possible to use a single internally consistent resource that could be applied to multiple types of experiments for these applications. OBI has made this possible by creating terms for entities involved in biological and medical investigations and by importing parts of other biomedical ontologies such as GO, Chemical Entities of Biological Interest (ChEBI) and Phenotype Attribute and Trait Ontology (PATO) without altering their meaning. OBI is being used in a wide range of projects covering genomics, multi-omics, immunology, and catalogs of services. OBI has also spawned other ontologies (Information Artifact Ontology) and methods for importing parts of ontologies (Minimum information to reference an external ontology term (MIREOT)). The OBI project is an open cross-disciplinary collaborative effort, encompassing multiple research communities from around the globe. To date, OBI has created 2366 classes and 40 relations along with textual and formal definitions. The OBI Consortium maintains a web resource providing details on the people, policies, and issues being addressed in association with OBI. (shrink)

BackgroundPlagiarism is common and threatens the integrity of the scientific literature. However, its detection is time consuming and difficult, presenting challenges to editors and publishers who are entrusted with ensuring the integrity of published literature.MethodsIn this study, the extent of plagiarism in manuscripts submitted to a major specialty medical journal was documented. We manually curated submitted manuscripts and deemed an article contained plagiarism if one sentence had 80 % of the words copied from another published paper. Commercial plagiarism detection software (...) was utilized and its use was optimized.ResultsIn 400 consecutively submitted manuscripts, 17 % of submissions contained unacceptable levels of plagiarized material with 82 % of plagiarized manuscripts submitted from countries where English was not an official language. Using the most commonly employed commercial plagiarism detection software, sensitivity and specificity were studied with regard to the generated plagiarism score. The cutoff score maximizing both sensitivity and specificity was 15 % (sensitivity 84.8 % and specificity 80.5 %).ConclusionsPlagiarism was a common occurrence among manuscripts submitted for publication to a major American specialty medical journal and most manuscripts with plagiarized material were submitted from countries in which English was not an official language. The use of commercial plagiarism detection software can be optimized by selecting a cutoff score that reflects desired sensitivity and specificity. (shrink)

The shortage of organs for transplantation by its nature prompts ethical dilemmas. For example, although there is an imperative to save human life and reduce suffering by maximising the supply of vital organs, there is an equally important obligation to ensure that the process by which we increase the supply respects the rights of all stakeholders. In a relatively unexamined practice in the USA, organs are procured from unrepresented decedents without their express consent. Unrepresented decedents have no known healthcare wishes (...) or advance care planning document; they also lack a surrogate. The Revised Uniform Anatomical Gift Act of 2006 sends a mixed message about the procurement of organs from this patient population and there are hospitals that authorise donation. In addition, in adopting the RUAGA, some states included provisions that clearly allow organ procurement from unrepresented decedents. An important unanswered question is whether this practice meets the canons of ethical permissibility. The current Brief Report presents two principled approaches to the topic as a way of highlighting some of the complexities involved. Concluding remarks offer suggestions for future research and discussion. (shrink)

In 2012, a U.S. Institute of Medicine report called for a different approach to health care: “Left unchanged, health care will continue to underperform; cause unnecessary harm; and strain national, state, and family budgets.” The answer, they suggested, would be a “continuously learning” health system. Ethicists and researchers urged the creation of “learning health organizations” that would integrate knowledge from patient‐care data to continuously improve the quality of care. Our experience with an ongoing research study on atrial fibrillation—a trial known (...) as IMPACT‐AFib—gave us some insight into one of the challenges that will have to be dealt with in creating these organizations. Although the proposed educational intervention study placed no restrictions on what providers and health plans could do, the oversight team argued that the ethical principle of beneficence did not allow the researchers to be “bystanders” in relation to a control group receiving suboptimal care. In response, the researchers designed a “workaround” that allowed the project to go forward. We believe the experience suggests that what we call “bystander ethics” will create challenges for the kinds of quality improvement research that LHOs are designed to do. (shrink)

In 2012, a U.S. Institute of Medicine report called for a different approach to health care: “Left unchanged, health care will continue to underperform; cause unnecessary harm; and strain national, state, and family budgets.” The answer, they suggested, would be a “continuously learning” health system. Ethicists and researchers urged the creation of “learning health organizations” that would integrate knowledge from patient‐care data to continuously improve the quality of care. Our experience with an ongoing research study on atrial fibrillation—a trial known (...) as IMPACT‐AFib—gave us some insight into one of the challenges that will have to be dealt with in creating these organizations. Although the proposed educational intervention study placed no restrictions on what providers and health plans could do, the oversight team argued that the ethical principle of beneficence did not allow the researchers to be “bystanders” in relation to a control group receiving suboptimal care. In response, the researchers designed a “workaround” that allowed the project to go forward. We believe the experience suggests that what we call “bystander ethics” will create challenges for the kinds of quality improvement research that LHOs are designed to do. (shrink)

Nanoethics seeks to examine the potential risks and rewards of applications of nanotechnology. This up-to-date anthology gives the reader an introduction to and basic foundation in nanotechnology and nanoethics, and then delves into near-, mid-, and far-term issues. Comprehensive and authoritative, it: -/- - Goes beyond the usual environmental, health, and safety (EHS) concerns to explore such topics as privacy, nanomedicine, human enhancement, global regulation, military, humanitarianism, education, artificial intelligence, space exploration, life extension, and more -/- -Features contributions from forty (...) preeminent experts from academia and industry worldwide, reflecting diverse perspectives -/- -Includes seminal works that influence nanoethics today -/- -Encourages an informed, proactive approach to nanoethics and advocates addressing new and emerging controversies before they impede progress or impact our welfare -/- This resource is designed to promote further investigations and a broad and balanced dialogue in nanoethics, dealing with critical issues that will affect the industry as well as society. While this will be a definitive reference for students, scientists in academia and industry, policymakers, and regulators, it's also a valuable resource for anyone who wants to understand the challenges, principles, and potential of nanotechnology. (shrink)

This paper presents the principal findings from a three-year research project funded by the US National Science Foundation on ethics of human enhancement technologies. To help untangle this ongoing debate, we have organized the discussion as a list of questions and answers, starting with background issues and moving to specific concerns, including: freedom & autonomy, health & safety, fairness & equity, societal disruption, and human dignity. Each question-and-answer pair is largely self-contained, allowing the reader to skip to those issues of (...) interest without affecting continuity. (shrink)

We are immersed within an odorous sea of chemical currents that we parse into individual odors with complex structures. Odors have been posited as determined by the structural relation between the molecules that compose the chemical compounds and their interactions with the receptor site. But, naturally occurring smells are parsed from gaseous odor plumes. To give a comprehensive account of the nature of odors the chemosciences must account for these large distributed entities as well. We offer a focused review of (...) what is known about the perception of odor plumes for olfactory navigation and tracking, which we then connect to what is known about the role odorants play as properties of the plume in determining odor identity with respect to odor quality. We end by motivating our central claim that more research needs to be conducted on the role that odorants play within the odor plume in determining odor identity. (shrink)

Ethical Politics and Modern Society introduces and critically examines British idealist philosopher, Thomas Hill Green, his practical philosophy and its reception in China between the late nineteenth century and the early twentieth century. As a response to the modernity issue in Great Britain, Green's philosophy, in particular his ethical politics, anticipated a practical solution to the individual alienation issue in modern society. Witnessing the resemblance between Green's ethical politics and classical Chinese ethical and political thought, some Chinese scholars became inclined (...) to take Green's thought as an intellectual approach to assimilate Western modernity. While Green and the Chinese scholars both intended to articulate an ethical conception of modern politics in response to the issue of modernity, their results were very different. In this book, James Jia-Hau Liu analyses why modern Chinese scholars introduced Green's philosophy to China and why the studies of Green's philosophy in China have since faded away. Modern Chinese scholars, such as Gao Yi-Han, Chin Yueh-Lin, Tang Jun-Yi, Chang Fo-Chuan and Yin Hai-Guang, are explored in greater detail. The contradictory standings towards modernity between Green and Chinese scholars illustrate how to understand the difference forms of modernity that can be embodied therein. Ethical Politics and Modern Society is a valuable resource to scholars of political philosophy, political theory, history of social and political thought, British Idealism and the work of Thomas Hill Green. (shrink)

In this paper we explain our pretense account of truth-talk and apply it in a diagnosis and treatment of the Liar Paradox. We begin by assuming that some form of deflationism is the correct approach to the topic of truth. We then briefly motivate the idea that all T-deflationists should endorse a fictionalist view of truth-talk, and, after distinguishing pretense-involving fictionalism (PIF) from error- theoretic fictionalism (ETF), explain the merits of the former over the latter. After presenting the basic framework (...) of our PIF account of truth-talk, we demonstrate a few advantages it offers over T-deflationist accounts that do not explicitly acknowledge pretense at work in the discourse. In turning to the Liar Paradox, we explain how the quasi-anaphoric functioning that our account attributes to truth-talk provides a diagnosis of the Liar Paradox (and other instances of semantic pathology) as having no content—in the sense of not specifying any of what we call M-conditions. At the same time, however, we vindicate the intuition that we can understand liar sentences, thereby avoiding one standard objection to “meaningless strategy” responses to the Liar Paradox. With this diagnosis in place, we then, by way of treatment, introduce a new predicate, ‘semantically defective’, and show how the explanation we give for its application allows for a consistent, yet revenge-immune, (dis)solution of the Liar Paradox, and semantic pathology generally. (shrink)

It is unfortunate that Francis Y. Lin, in ‘Chomsky on the “ordinary language” view of language’ pays little attention to his own remark, ‘Chomsky’s criticisms make us realize that we should not be content with general and vague formulations of convention, ability, and so on. We must make such notions precise and provide details’ Lin speaks so imprecisely and provides so few details of notions on which he relies heavily, such as ‘general learning mechanism’ and ‘sentence frame’, that readers must (...) employ large amounts of guesswork to place even a halfway specific interpretation on his proposals and claims. (shrink)

Among the reasons that Whitehead is such an interesting philosopher is that his work resonates across philosophical traditions. This collection develops connections between Whiteheadian concepts and recent European thinkers. The purpose is not simply to compare, however, but, as editor Jeremy Fackenthal suggests, to develop a Whiteheadian thinking “in tandem” with European philosophers in order to create disruptions or “dislocations” in thought that can engender creative approaches to contemporary problems.One general feature of the book deserves mention at the outset, though (...) I will return to it later in the review: although phenomenology and hermeneutics are each represented in the volume, roughly half of the essays focus on the work of Gilles Deleuze (if we group these together with essays focused on “new materialism,” which is connected with Deleuze, the proportion is more like two-thirds). This will be no surprise, since Deleuze is the European philosopher who was most appreciative of Whitehead. And yet, the result is that the conversation with “continental philosophy” is highly selective.The book is organized into three parts, each comprised of three essays. In part 1, “Technological and Systematic Dislocations,” William S. Hamrick brings Whitehead into conversation with Maurice Merleau-Ponty's concept of “the flesh” to suggest an ecological ontology capable of overcoming the instrumentalization of nature. Hamrick's strategy is to read Whitehead and Merleau-Ponty as contributing to an “ontological foundation” for a sustainable civilization (18). Bo Eberle writes about the “quantified self” suggested in new, wearable self-monitoring technologies. Drawing on Whitehead's notion of causal efficacy, Eberle argues that devices such as Fitbit give us access to bodily states that bypasses the standard ways we are aware of ourselves (i.e., through consciousness). He goes further to argue that, like all ways of knowing, wearable technologies are selective, and that the selection reflects the interests of the manufacturers and promotes a certain kind of subjectivity (in the case of Fitbit, a subjectivity that is oriented toward “getting your steps in”). Whitehead's epistemology thus enables the critic of wearable technologies to understand how contemporary experience and self-understanding is shaped not simply by recent technological mediations but by the material interests embedded in them. J.R. Hustwit and Carl Dyke take on what they call “activist” uses of Whitehead that naively (in their judgment) suggest that a non-relational substance metaphysics is to blame for most of our social ills. They employ the theory of complex adaptive systems in conversation with Whitehead and Antonio Gramsci to show that, in fact, achieving significant social change is far more difficult and even unpredictable than mere insertion of better ideas into public discourse. Dominant hegemonies have ways of adapting and absorbing attempts to undermine them. Here Hustwit and Dyke draw on the philosophy of Paul Ricoeur to suggest that resistance to the dominant hegemony is nevertheless always possible because of the vagueness of discourse, allowing a plurality of competing interpretations and thus fractures in the dominant hegemony. However, even this kind of resistance is impossible to control and its effects incapable of being entirely predicted. To the essay's titular question, “Can Whitehead save the world?” the authors answer, “No.”In part 2, “Animal/Human Dislocations,” Jeremy Fackenthal draws on the new materialism of Rosi Braidotti (and Deleuze) along with Whitehead to argue for a “process-relational” nomadism that culminates in a “becoming-imperceptible.” His reading together of Whitehead and Braidotti creates the opportunity to recast the former's concept of objective immortality in such a way that it does not refer to death so much as to being diffused into a relational network. The satisfaction of an actual occasion may be taken as its translation into its effects among its relations. Fackenthal argues that this becoming-imperceptible makes possible a sustainable presence within a fragile network of life. Deena M. Lin uses Whitehead, Braidotti, and Judith Butler to lay out a vision of human life as precarious and deserving attention, care, and solidarity. She presses this vision as a direct moral assault on US (Trump's) policy toward Syrian refugees. Going further, she draws on Braidotti's posthuman account of zoe to argue for universal connection and solidarity with all life that should foster, as the title of her essay puts it, “Welcoming of Syrian Life.” Tano Posteraro offers an intriguing essay drawing on Jakob von Uexküll's account of animal experience. Posteraro argues that Uexküll's notion of an animal's Umwelt, shaped by its distinctive perceptual apparatus, needs to be supplemented by Whitehead's notion of prehension to account for the active dimension of animal perception. Rather than a passive registering of animal environments, Posteraro argues that the latter are constructed, and that concepts (or conceptual prehensions) should be understood as tools with which such environments are constructed.In part 3, “Time, the World, and Abstraction,” three essays probe ways that Whiteheadian and Deleuzian themes may resonate critically and constructively. Kris Klotz brings the thought of Whitehead and Deleuze together to inquire about how alternatives to present social forms are envisioned. He argues that, for Whitehead, every actual occasion involves a selection of some features of the past, and, further, that every selection is also an abstraction from the concrete welter of influences impinging on it. For Whitehead, then, to envision alternatives involves a critique of abstractions, a reinstatement of the concrete plurality of possibilities. This, for Whitehead, is what rationality does: it works at restoring the concrete, and, with it, a series of alternatives that have been eclipsed. To this Whiteheadian analysis, Klotz adds Deleuze and Guattari's critique of “opinion.” For Deleuze and Guattari, opinion is not an idiosyncrasy but a consensus to which differences of experience are subjected. Philosophy, for Deleuze and Guattari, must always struggle against opinion in order to bring alternatives to light. These conceptions of reason/philosophy, Klotz argues, represent useful ways to critique inequalities and other social wrongs that are embedded in the social forms that are routinely taken for granted. Elijah Prewitt-Davis uses a scene from Buffy the Vampire Slayer, along with philosophical innovations of Foucault, Deleuze, and Whitehead, to offer a distinctive account of power. Prewitt-Davis calls attention to Deleuze's important book on Leibniz, The Fold, and to how Whitehead's concept of prehension lies at its center. The upshot is that power is not reduced to dominance but, instead, is at work wherever any occasion of experience persists amid the onslaught of the influence of other occasions. Power, as Deleuze wrote, is the capacity to be affected—and to decide how to constitute oneself anew. Keith Robinson offers a detailed account of Whitehead's epistemology along with a reading of Deleuze's analysis of temporality to suggest that there is a common trajectory that seeks to undermine what the title of the essay describes as the “Bifurcation of Nature” (i.e., the separation of natural phenomena and human experience) within the dominant Western philosophical tradition.There is much of value in the volume as a whole. Aside from staging what Spinoza might have called good encounters between Whitehead and a number of continental philosophers, enhancing the conceptual power of each, the contributors are able to make a case that these philosophical trajectories, when read together, have much to contribute to our understanding of and response to the pressing issues of the day. In addition, readers who are interested in the relationship between Whitehead and the new materialism will find this volume to be a helpful resource, stocked with fine examples of how to sharpen new materialist thinking with Whitehead and how to read contemporary contexts through these lenses. On the other hand, this book is not a handbook nor a comprehensive reference. The organizational logic behind its division into sections is murky and the amount of attention given to particular continental philosophers as opposed to others appears somewhat arbitrary: there are recent continental philosophers who get little to no attention at (Derrida, Malabou, Žižek, Agamben, Latour, Nancy, for example), several of whom might prove to be quite interesting to read “in tandem” with Whitehead. Perhaps that is just to say that there are many more essays to be written. (shrink)

Based on the results of open ended interviews with managers in a variety of organizational positions, moral questions encountered in everyday managerial life are described. These involve transactions with employees, peers and superiors, customers, suppliers and other stakeholders. It is suggested that managers identify transactions as involving personal moral concern when they believe that a moral standard has a bearing on the situation and when they experience themselves as having the power to affect the transaction. This is the first in (...) a research series of three papers. (shrink)

The lack of concrete guidance provided by managerial moral standards and the ambiguity of the expectations they create are discussed in terms of the moral stress experienced by many managers. It is argued that requisite clarity and feelings of obligation with respect to moral standards derive ultimately from public discussion of moral issues within organizations and from shared public agreement about appropriate behavior. Suggestions are made about ways in which the moral dimension of an organization's culture can be more effectively (...) managed. This is the third in a research series of three papers. (shrink)

Discourses between Ayōttitācar, 1845-1914 and Ma. Ciṅkāravēlu,1860-1946 on Buddhism. These were published in Tamilan̲, Tamil magazine, published between 1907-1914.

Discourses between Ayōttitācar, 1845-1914 and Ma. Ciṅkāravēlu,1860-1946 on Buddhism. These were published in Tamilan̲, Tamil magazine, published between 1907-1914.

On the ideas of Ayōttitācar,1845-1914, on Buddhism and medicine.

Based on analysis of interviews with managers about the ethical questions they face in their work, a typology of morally questionable managerial acts is developed. The typology distinguishes acts committed against-the-firm (non-role and role-failure acts) from those committed on-behalf-of-the-firm (role-distortion and role-as-sertion acts) and draws attention to the different nature of the four types of acts. The argument is made that senior management attention is typically focused on the types of acts which are least problematical for most managers, and that (...) the most troublesome types are relatively ignored. (shrink)

A detailed account of certain traits of intellectual character—the epistemic virtues—and of their relation to the responsibility for one's beliefs.

What big questions and large‐scale narratives give coherence to the history of science? From the late 1970s onward, the field has been transformed through a stress on practice and fresh perspectives from gender studies, the sociology of knowledge, and work on a greatly expanded range of practitioners and cultures. Yet these developments, although long overdue and clearly beneficial, have been accompanied by fragmentation and loss of direction. This essay suggests that the narrative frameworks used by historians of science need to (...) come to terms with diversity by understanding science as a form of communication. The centrality of processes of movement, translation, and transmission is already emerging in studies of topics ranging from ethnographic encounters to the history of reading. Not only does this approach offer opportunities for crossing boundaries of nation, period, and discipline that are all too easily taken for granted; it also has the potential for creating a more effective dialogue with other historians and the wider public. (shrink)

What big questions and large‐scale narratives give coherence to the history of science? From the late 1970s onward, the field has been transformed through a stress on practice and fresh perspectives from gender studies, the sociology of knowledge, and work on a greatly expanded range of practitioners and cultures. Yet these developments, although long overdue and clearly beneficial, have been accompanied by fragmentation and loss of direction. This essay suggests that the narrative frameworks used by historians of science need to (...) come to terms with diversity by understanding science as a form of communication. The centrality of processes of movement, translation, and transmission is already emerging in studies of topics ranging from ethnographic encounters to the history of reading. Not only does this approach offer opportunities for crossing boundaries of nation, period, and discipline that are all too easily taken for granted; it also has the potential for creating a more effective dialogue with other historians and the wider public. (shrink)

Halford et al.'s analysis of relational complexity provides a possible framework for characterizing the symbolic functions of the prefrontal cortex. Studies of prefrontal patients have revealed that their performance is selectively impaired on tasks that require integration of two binary relations (i.e., tasks that Halford et al.'s analysis would identify as three-dimensional). Analyses of relational complexity show promise of helping to understand the neural substrate of thinking.

Quantum mechanics tells us that states involving indistinguishable fermions must be antisymmetrized. This is often taken to mean that indistinguishable fermions are always entangled. We consider several notions of entanglement and argue that on the best of them, indistinguishable fermions are not always entangled. We also present a simple but unconventional way of representing fermionic states that allows us to maintain a link between entanglement and non-factorizability.

This paper addresses theoretical problems arising from the vagueness of language terms, and intuitions of the vagueness of the concepts to which they refer. It is argued that the central intuitions of prototype theory are sufficient to account for both typicality phenomena and psychological intuitions about degrees of membership in vaguely defined classes. The first section explains the importance of the relation between degrees of membership and typicality (or goodness of example) in conceptual categorization. The second and third section address (...) arguments advanced by Osherson and Smith (1997), and Kamp and Partee (1995), that the two notions of degree of membership and typicality must relate to fundamentally different aspects of conceptual representations. A version of prototype theory—the Threshold Model—is proposed to counter these arguments and three possible solutions to the problems of logical selfcontradiction and tautology for vague categorizations are outlined. In the final section graded membership is related to the social construction of conceptual boundaries maintained through language use. (shrink)

The Self We Live By confronts the serious challenges facing the self in postmodern times. Taking issue with contemporary trivializations of the self, the book traces a course of development from the early pragmatists who formulated what they called the 'empirical self', to contemporary constructionist views of the storied self. Presenting an institutional context for the increasing complexity and ubiquity of narrative identity, the authors illustrate the 'everyday technology of self construction' and idscuss the resulting moral climate. The book is (...) suitable for advanced undergraduates and graduate students in courses such as Individual in Society, Contemporary American Society, Social Psychology, Social Interaction and Culture & Personality. (shrink)

Because recent contributions on world government in the international relations (IR) literature have focused on relatively nebulous issues, they are of limited usefulness for illuminating whether or not an actual world government would advance the human prospect. This question cannot be sensibly addressed unless in the light of a specific institutional proposal. Along the authority-effectiveness continuum separating the relatively ineffectual existent United Nations on the one hand, and the traditional world federalist ideal of the omnipotent world state on the other, (...) there are intermediate possibilities not subject to the respective disadvantages of the extreme endpoints of this continuum. (shrink)

The philosophical literature on scientific explanation contains a striking diversity of accounts. I use novel empirical methods to address this fragmentation and assess the importance and generality of explanation in science. My evidence base is a set of 781 articles from one year of the journal Science, and I begin by applying text mining techniques to discover patterns in the usage of “explain” and other words of philosophical interest. I then use random sampling from the data set to develop and (...) test a classification scheme for scientific explanation. My results show that explanation and inference to the best explanation are ubiquitous in science, that they occur across a wide range of scientific disciplines, and that they are a goal of scientific practise. These explanations and inferences to the best explanation come in a diversity forms, which at least partially justifies the fragmentation of philosophical accounts. I draw two methodological lessons: first that text mining can enhance traditional conceptual analysis by establishing facts about word usage; and second that random sampling of cases can increase our confidence that a philosophical account applies in general. These empirical techniques supplement traditional philosophical methods. (shrink)

As an alternative to using the concepts of emotion, fear, anger, and the like as scientific tools, this article advocates an approach based on the concepts of core affect and psychological construction, expanding the domain of inquiry beyond “emotion”. Core affect is a neurophysiological state that underlies simply feeling good or bad, drowsy or energised. Psychological construction is not one process but an umbrella term for the various processes that produce: (a) a particular emotional episode's “components” (such as facial movement, (...) vocal tone, peripheral nervous system change, appraisal, attribution, behaviour, subjective experience, and emotion regulation); (b) associations among the components; and (c) the categorisation of the pattern of components as a specific emotion. (shrink)

This is the first book to provide a comprehensive overview of the entire career of one of Britain's greatest men of letters. It sets in biographical and historical context all of Hume's works, from A Treatise of Human Nature to The History of England, bringing to light the major influences on the course of Hume's intellectual development, and paying careful attention to the differences between the wide variety of literary genres with which Hume experimented. The major events in Hume's life (...) are fully described, but the main focus is on Hume's intentions as a philosophical analyst of human nature, politics, commerce, English history, and religion. Careful attention is paid to Hume's intellectual relations with his contemporaries. The goal is to reveal Hume as a man intensely concerned with the realization of an ideal of open-minded, objective, rigorous, dispassionate dialogue about all the principal questions faced by his age. (shrink)

Feeling bad is one thing, judging something to be bad another. This hot/cold distinction helps resolve the debate between bipolar and bivariate accounts of affect. A typical affective reaction includes both core affect and judgments of the affective qualities of various aspects of the stimulus situation. Core affect is described by a bipolar valence dimension in which feeling good precludes simultaneously feeling bad and vice versa. Judgments of affective quality of opposite valence can occur simultaneously because the stimulus situation has (...) many aspects. Affective reaction can also include an emotional meta-experience, which can, but rarely does, embrace simultaneous emotion categories of opposite valence. (shrink)

Nietzsche criticizes Stoicism for overstating the significance of its ethical ideal of rational self-sufficiency and for undervaluing pain and passion when pursuing an unconditional acceptance of fate. Apparent affinities between Stoicism and Nietzsche’s philosophy, especially his celebration of self-mastery and his pursuit of amor fati, lead some scholars to conclude that Nietzsche cannot advance these criticisms without contradicting himself. In this article, I narrow the target and scope of Nietzsche’s complaints against Stoicism before showing how they follow from his other (...) philosophic commitments. I suggest that the first line of criticism follows from his denial of teleology and his skepticism toward moral values’ descriptive objectivity. I then suggest that the second line of criticism follows from Nietzsche’s account of overcoming as bestowing contributory value upon pain and suffering. Explaining Nietzsche’s criticisms of Stoicism in this way substantially qualifies similarities between his philosophy and that of Stoicism while absolving him of the charge of inconsistency. (shrink)

The complex-systems approach to cognitive science seeks to move beyond the formalism of information exchange and to situate cognition within the broader formalism of energy flow. Changes in cognitive performance exhibit a fractal (i.e., power-law) relationship between size and time scale. These fractal fluctuations reflect the flow of energy at all scales governing cognition. Information transfer, as traditionally understood in the cognitive sciences, may be a subset of this multiscale energy flow. The cognitive system exhibits not just a single power-law (...) relationship between fluctuation size and time scale but actually exhibits many power-law relationships, whether over time or space. This change in fractal scaling, that is, multifractality, provides new insights into changes in energy flow through the cognitive system. We survey recent findings demonstrating the role of multifractality in (a) understanding atypical developmental outcomes, and (b) predicting cognitive change. We propose that multifractality provides insights into energy flows driving the emergence of cognitive structure. (shrink)