The classic model of blood pressure regulation by Guyton et al. (Annu Rev Physiol 34:13–46, 1972a; Ann Biomed Eng 1:254–281, 1972b) set a new standard for quantitative exploration of physiological function and led to important new insights, some of which still remain the focus of debate, such as whether the kidney plays the primary role in the genesis of hypertension (Montani et al. in Exp Physiol 24:41–54, 2009a; Exp Physiol 94:382–388, 2009b; Osborn et al. in Exp Physiol 94:389–396, 2009a; Exp (...) Physiol 94:388–389, 2009b). Key to the success of this model was the fact that the authors made the computer code (in FORTRAN) freely available and eventually provided a convivial user interface for exploration of model behavior on early microcomputers (Montani et al. in Int J Bio-med Comput 24:41–54, 1989). Ikeda et al. (Ann Biomed Eng 7:135–166, 1979) developed an offshoot of the Guyton model targeting especially the regulation of body fluids and acid–base balance; their model provides extended renal and respiratory functions and would be a good basis for further extensions. In the interest of providing a simple, useable version of Ikeda et al.’s model and to facilitate further such extensions, we present a practical implementation of the model of Ikeda et al. (Ann Biomed Eng 7:135–166, 1979), using the ODE solver Berkeley Madonna. (shrink)

La 4e de couverture indique : "Comment se pratique la philosophie du droit en ce début de XXIe siècle à la suite des bouleversements politiques et théoriques observés lors du siècle précédent? Comment se pose la question du droit pour et dans la philosophie, et quelles sont les spécificités du rapport que les juristes nouent à la philosophie dans le déploiement de leur pratique juridique, ainsi que dans leur propre réflexion sur le droit? Les textes présents dans ce volume, rédigés (...) en l'honneur de Guy Haarscher par des amis et des collègues influencés par son travail, abordent ce questionnement en profitant, à sa suite, de la multiplicité des espaces de croisement entre les discours juridiques et philosophiques, qu'il s'agisse de la spécificité des droits de l'homme ou du droit constitutionnel dans le champ juridique, des choix moraux à l'oeuvre lors des conflits entre droits fondamentaux, de la place de la rhétorique ou de l'utilisation de la philosophie dans la procédure judiciaire, du statut réservé à la technique juridique dans la tradition philosophique occidentale, d'un légalisme commun au jusnaturalisme et au juspositivisme, d'une forme de moralité purement interne à la pratique du droit, de la question du tribunal de l'histoire ou encore du sens juridique de la laïcité.". (shrink)

This paper treats a heretofore-unnoticed concept in the history of the philosophical discussion of human freedom, a kind of freedom that is not defined solely in terms of the causal power of the agent. Instead, the exercise of freedom essentially involves the non-occurrence of something. That being free involves the non-occurrence, that is, the absence, of an act may seem counterintuitive. With the exception of those specifically treated in this paper, philosophers tend to think of freedom as intimately involved with (...) volition, the judging or deciding activity of the will that votes in favor of or against a proposed action. However, there are two thinkers who endorse a view where not willing constitutes human freedom. Our analysis focuses on the views of Malebranche and Locke. Both invoke a notion dubbed here as ‘absential suspension.’ On this view, freedom is associated not with the power of volition, but rather with this kind of suspension. (shrink)

The Quietist affair at the end of the seventeenth century has much to teach us about theories of the will in the period. Although Bossuet and Fénelon are the names most famously associated with the debate over the Quietist conception of pure love, Malebranche and his erstwhile disciple Lamy were the ones who debated the deep philosophical issues involved. This paper sets the historical context of the debate, discusses the positions as well as the arguments for and against them, and (...) opens up investigation of important material that is all but ignored in the English literature and only incompletely addressed in the French. (shrink)

Vulnerability acts as a touchstone in this issue as we find our contributors reflecting on its intersection with gender and sexuality in different ways. Saeidzadeh draws out the significance of misrecognition in her consideration of responses to transsexuality in Iran, while Doonan highlights the potential pitfalls of relying on situational vulnerability in her critique of anti-trafficking legal discourse in the US. Lindsey considers the legal potential of situational vulnerability as a tool to address the ‘persistent failure to take action against (...) abuse’ in the UK. Durojaye and Oluduro contribute to the recent revitalisation in asking ‘the woman question’ by drawing on African law and literature to flesh out the development of a gender-sensitive, substantive equality approach from the jurisprudence of the African Commission on Human and Peoples’ Rights as it addresses vulnerability to violence. The reviewers continue this international conversation as they address recent contributions on sexuality, family formation and social security. (shrink)

The contributors to this issue focus on legal internationalism, including hybrid mixes with nationalist forms. They have provoked us as editors to think more about these sites and forms of engagement. Sankey shows how civic participation in the ECCC has played a key role in surfacing the gendered harms of separation and starvation. Turan highlights the problems with ICC exclusion of the experience of men and boys from sexual violence. Peroni expresses her hesitations over the Istanbul Convention given an association (...) between assumed vulnerability and migrant women, while admiring its uncoupling of violence and culture. Cruz’s interview with Wendy Brown contextualizes and expands on these themes as they consider, with other participants, the future of feminist theory in the context of neo-liberal capturing of rights and legal space. Thinking more about internationalism and commitment in this context also helps us hold a mirror up to ourselves as we reflect more critically on our own naming of FLS as an ‘international’ journal. Together these contributions, and the reviews of new work, play a role in fleshing out an editorial commitment to enacting the journal as a living thing that ‘hangs together somehow’ even as it is known differently in different places. (shrink)

Since the last issue of Feminist Legal Studies, we editorial board members have had lots of conversations about comfort, displacement and alienation. As we developed the programme for #FLaK2016 we thought about it as a kind of pulling ourselves out of our comfort zone, if academic events and journals ever have a comfort zone. Drawing on a mix of feminist live performance methods and a science and technology studies-type curiosity for objects of experimentation, we tried out a kitchen table method (...) of hosting a live research conversation with activists, artists and academics over two days. But we had not fully anticipated the way that the Brexit result would contribute to and complicate discomfort. A fuller analysis of FLaK awaits a later moment, but here we pick out this one aspect of our gathering—feelings of discomfort – as they animate the contributions to this issue in interesting ways. (shrink)

The expression “continental rationalism” refers to a set of views more or less shared by a number of philosophers active on the European continent during the latter two thirds of the seventeenth century and the beginning of the eighteenth. Rationalism is most often characterized as an epistemological position. On this view, to be a rationalist requires at least one of the following: (1) a privileging of reason and intuition over sensation and experience, (2) regarding all or most ideas as innate (...) rather than adventitious, (3) an emphasis on certain rather than merely probable knowledge as the goal of enquiry. While all of the continental rationalists meet one or more of these criteria, this is arguably the consequence of a deeper tie that binds them together—that is, a metaphysical commitment to the reality of substance, and, in particular, to substance as an underlying principle of unity. (shrink)

This volume addresses a wide variety of moral concerns regarding slavery as an institutionalized social practice. By considering the slave's critical appropriation of the natural rights doctrine, the ambiguous implications of various notions of consent and liberty are examined. The authors assume that, although slavery is undoubtedly an evil social practice, its moral assessment stands in need of a more nuanced treatment. They address the question of what is wrong with slavery by critically examining, and in some cases endorsing, certain (...) principles derived from communitarianism, paternalism, utilitarianism, and jurisprudence. (shrink)

This book's importance is derived from three sources: careful conceptualization of teacher induction from historical, methodological, and international perspectives; systematic reviews of research literature relevant to various aspects of teacher induction including its social, cultural, and political contexts, program components and forms, and the range of its effects; substantial empirical studies on the important issues of teacher induction with different kinds of methodologies that exemplify future directions and approaches to the research in teacher induction.

Picking up the question of what FLaK might be, this editorial considers the relationship between openness and closure in feminist legal studies. How do we draw on feminist struggles for openness in common resources, from security to knowledge, as we inhabit a compromised space in commercial publishing? We think about this first in relation to the content of this issue: on image-based abuse continuums, asylum struggles, trials of protestors, customary justice, and not-so-timely reparations. Our thoughts take us through the different (...) ways that openness and closure work in struggles against violence, cruel welcomes, and re-arrangements of code and custom. Secondly, we share some reflections on methodological openness and closure as the roundtable conversation on asylum, and the interview with Riles, remind us of #FLaK2016 and its method of scattering sources as we think about how best to mix knowledges. Thirdly, prompted by the FLaK kitchen table conversations on openness, publishing and ‘getting the word out’, we respond to Kember’s call to ‘open up open access’. We explain the different current arrangements for opening up FLS content and how green open access, the sharedit initiative, author request and publisher discretion present alternatives to gold open access. Finally drawing on Franklin and Spade, we show how there are a range of ‘wench tactics’—adapting gifts, stalling and resting—which we deploy as academic editors who are trying to have an impact on the access, use and circulation of our journal, even though we do not own the journal we edit. These wench tactics are alternatives to the more obvious or reported tactic of resignation, or withdrawing academic labour from editing and reviewing altogether. They help us think about brewing editorial time, what ambivalence over our 25th birthday might mean, and how to inhabit painful places. In this, we respond in our own impure, compromised way to da Silva’s call not to forget the native and slave as we do FLaK, and repurpose shrapnel, in our common commitments. (shrink)

Glycerol is a small and simple molecule produced in the breakdown of glucose, proteins, pyruvate, triacylglycerols and other glycerolipid, as well as release from dietary fats. An increasing number of observations show that glycerol is probably involved in a surprising variety of physiopathologic mechanisms. Glycerol has long been known to play fundamental roles in several vital physiological processes, in prokaryotes and eukaryotes, and is an important intermediate of energy metabolism. Despite some differences in the details of their operation, many of (...) these mechanisms have been preserved throughout evolution, demonstrating their fundamental importance. In particular, glycerol can control osmotic activity and crystal formation and then act as a cryoprotective agent. Furthermore, its properties make it useful in numerous industrial, therapeutic and diagnostic applications. Few studies have focussed directly on glycerol, however, and while its metabolism is increasingly well documented, much of the details remain unknown. Considering the importance of glycerol in multiple vital physiological processes, its study could help unlock important physiopathological mechanisms. BioEssays 23:534–542, 2001. © 2001 John Wiley & Sons, Inc. (shrink)

Biological evolution provides a creative fount of complex and subtle adaptations, often surprising the scientists who discover them. However, because evolution is an algorithmic process that transcends the substrate in which it occurs, evolution’s creativity is not limited to nature. Indeed, many researchers in the field of digital evolution have observed their evolving algorithms and organisms subverting their intentions, exposing unrecognized bugs in their code, producing unexpected adaptations, or exhibiting outcomes uncannily convergent with ones in nature. Such stories routinely reveal (...) creativity by evolution in these digital worlds, but they rarely fit into the standard scientific narrative. Instead they are often treated as mere obstacles to be overcome, rather than results that warrant study in their own right. The stories themselves are traded among researchers through oral tradition, but that mode of information transmission is inefficient and prone to error and outright loss. Moreover, the fact that these stories tend to be shared only among practitioners means that many natural scientists do not realize how interesting and lifelike digital organisms are and how natural their evolution can be. To our knowledge, no collection of such anecdotes has been published before. This paper is the crowd-sourced product of researchers in the fields of artificial life and evolutionary computation who have provided first-hand accounts of such cases. It thus serves as a written, fact-checked collection of scientifically important and even entertaining stories. In doing so we also present here substantial evidence that the existence and importance of evolutionary surprises extends beyond the natural world, and may indeed be a universal property of all complex evolving systems. (shrink)

It is often thought that religious experiences provide support for the cumulative case for the existence of the God of classical monotheism. In this paper, I formulate an Evil-god challenge that invites classical monotheists to explain why, based on evidence from religious experience, the belief in an omnipotent, omniscient, omnibenevolent god is significantly more reasonable than the belief in an omnipotent, omniscient, evil god. I demonstrate that religious experiences substantiate the existence of Evil-god more so than they do the existence (...) of Good-god, and, consequently, that the traditional argument from religious experience fails: it should not be included in the cumulative case for the existence of Good-god. (shrink)

This is a bibliography of books and articles on consciousness in philosophy, cognitive science, and neuroscience over the last 30 years. There are three main sections, devoted to monographs, edited collections of papers, and articles. The first two of these sections are each divided into three subsections containing books in each of the main areas of research. The third section is divided into 12 subsections, with 10 subject headings for philosophical articles along with two additional subsections for articles in cognitive (...) science and neuroscience. Of course the division is somewhat arbitrary, but I hope that it makes the bibliography easier to use. This bibliography has first been compiled by Thomas Metzinger and David Chalmers to appear in print in two philosophical anthologies on conscious experience . From 1995 onwards it has been continuously updated by Thomas Metzinger, and now is freely available as a PDF-, RTF-, or HTML-file. This bibliography mainly attempts to cover the Anglo-Saxon and German debates, in a non-annotated, fully formatted way that makes it easy to "cut and paste" from the original file. To a certain degree this bibliography also contains items in other languages than English and German - all submissions in other languages are welcome. Last update of current version: July 13th, 2001. (shrink)

‘The Science of the Soul is Surer than every other Science’. An Eckhartian Interpretation of Bearing Witness (John 8 :17). Why does the knowledge of the soul constitute the surest science, according to the thesis that Meister Eckhart takes from Aristotle? Here is the reason he gives : «Concerning what is within us, we are not seeking the testimony and approval of anyone else». But the argument of the uselessness of the testimony of another seems paradoxical in the context in (...) which it appears : the commentary on the verse in John 8 :17 which is precisely about basing the certainty of the testimony as knowledge through the mediation of another. How are we to understand this paradox? My assumption is that it is necessary to consider the point at which the doctrinal aspect of this commentary about bearing witness and its hermeneutical aspect in relation to the interpretation of Scripture are in agreement. From the perspective of doctrine, Meister Eckhart, reinterpreting John Chrysostom, Augustine and Thomas Aquinas, aims to overturn the conception of noetic mediation into one of immediacy, basing this on the Trinitarian theory of the begetting of the Son by the Father in consubstantiality. Therefore otherness and exteriority are led back towards unity of nature and inwardness. And certain knowledge coincides with the knowledge of the principle of one’s own being. From a hermeneutical perspective, the exegesis of the verse according to its latent meaning suggested by Eckhart becomes for him a model of metaphysical and noetic interpretation : to understand in what way the one who is testifying to the principle that has engendered him delivers the most certain knowledge, it is necessary to move from the patent meaning of being and of knowledge to their latent meaning. To this extent, all knowledge through mediation that is demonstrated as external knowledge is revealed to be, in a latent sense, a manifestation of truth as an act of engendering. (shrink)

‘The Science of the Soul is Surer than every other Science’. An Eckhartian Interpretation of Bearing Witness (John 8 :17). Why does the knowledge of the soul constitute the surest science, according to the thesis that Meister Eckhart takes from Aristotle? Here is the reason he gives : «Concerning what is within us, we are not seeking the testimony and approval of anyone else». But the argument of the uselessness of the testimony of another seems paradoxical in the context in (...) which it appears : the commentary on the verse in John 8 :17 which is precisely about basing the certainty of the testimony as knowledge through the mediation of another. How are we to understand this paradox? My assumption is that it is necessary to consider the point at which the doctrinal aspect of this commentary about bearing witness and its hermeneutical aspect in relation to the interpretation of Scripture are in agreement. From the perspective of doctrine, Meister Eckhart, reinterpreting John Chrysostom, Augustine and Thomas Aquinas, aims to overturn the conception of noetic mediation into one of immediacy, basing this on the Trinitarian theory of the begetting of the Son by the Father in consubstantiality. Therefore otherness and exteriority are led back towards unity of nature and inwardness. And certain knowledge coincides with the knowledge of the principle of one’s own being. From a hermeneutical perspective, the exegesis of the verse according to its latent meaning suggested by Eckhart becomes for him a model of metaphysical and noetic interpretation : to understand in what way the one who is testifying to the principle that has engendered him delivers the most certain knowledge, it is necessary to move from the patent meaning of being and of knowledge to their latent meaning. To this extent, all knowledge through mediation that is demonstrated as external knowledge is revealed to be, in a latent sense, a manifestation of truth as an act of engendering. (shrink)

Aberrations and variations within kinds of creatures required explanation to Western medievals, who took the Genesis creation narratives together with Aristotelian species to imply that change was limited to within species; consequently, species were presumed static. Medieval philosophers often explained variation—including “new” kinds like mules—as due to problems in procreation/gestation (following Aristotle) or by sin. I argue that Aquinas's explanation of variation in women, people with disabilities, and mules suggests that Aquinas cannot be taken to entirely reject the possibility of (...) new kinds, and parallels in his explanation of the existence of women and the possible existence of new kinds provides warrant for a re‐evaluation of his understanding of the notion of the natures or essences shared by kinds. Sin—individual or original—is an inadequate explanation for variation, and the argumentative parallels between Aquinas's treatment of women and mules challenge presumptions about what medievals mean by “static kinds” at all, revealing space for evolutionary thought. (shrink)

Volume 20, Issue 7, July 2020, Page 139-141.

Volume 20, Issue 7, July 2020, Page 125-128.

What follows is an English reading of the first edition of Martin Heidegger's inaugural lecture at Freiburg University,“Was ist Metaphysik?” delivered on Wednesday, July 24, 1929. The German text was first published in December of 1929, some five months after it was delivered, by Friedrich Cohen Verlag in Bonn, to whose heirs gratitude is expressed for the requisite arrangements. The original German publication of 1929 differs in a number of relatively minor ways from later editions -- for example, changes in (...) wording, additions of certain phrases (and at one place two sentences), paragraphization, and the like – without any basic alteration of sense. Some of those changes are listed in an appendix at the end. (shrink)

In this paper I respond to separate criticisms by Bill Shaw (JBE, July 1988) and Richard Nunan (JBE, December 1988) of my paper A Critique of Milton Friedman's Essay The Social Responsibility of Business Is to Increase Its Profits (JBE, August 1986). Professors Shaw and Nunan identify several points where my argument could benefit from clarification and improvement. They also make valuable contributions to the discussion of the broad issue area of whether and to what extent business should exercise moral (...) initiative.My objectives are (1) to show, with the aid of examples (inspired by Shaw) and the addition of one point of correction (inspired by Nunan), that my disapproving critique of Friedman's famous argument remains sound, (2) to show that Professor Shaw's argument contains serious problems, and (3) to build on the base laid by my critics by developing important reasons why business should exercise moral initiative. (shrink)

This thought piece dealing with the Covid-19 ‘crisis’ was written – in the form of a diary that runs from February to July 2020 – for a special issue of Derrida Today entitled ‘Fire, Flood, Pestilence and Protest’, edited by Nicole Anderson, and published in November 2020. The piece deals with matters of biopolitics, telecommunication, death and mourning through Derrida and Agamben, and interrogates the eventness of what is called an ‘event’.

Brian Butler Transgression: Ordinary and Otherwise _Film-Philosophy_, vol. 5 no. 22, July 2001.

Volume 20, Issue 7, July 2020, Page W15-W16.

Volume 20, Issue 7, July 2020, Page 95-97.

The Heythrop Journal, Volume 63, Issue 4, Page 626-637, July 2022.

In this paper, the notion of structural completeness is explored in the context of a generalized class of superintuitionistic logics involving also systems that are not closed under uniform substitution. We just require that each logic must be closed under D-substitutions assigning to atomic formulas only ∨\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$\vee $$\end{document}-free formulas. For these systems we introduce four different notions of structural completeness and study how they are related. We focus on superintuitionistic inquisitive logics (...) that validate a schema called Split and have the disjunction property. In these logics disjunction can be interpreted in the sense of inquisitive semantics as a question forming operator. It is shown that a logic is structurally complete with respect to D-substitutions if and only if it includes the weakest superintuitionistic inquisitive logic. Various consequences of this result are explored. For example, it is shown that every superintuitionistic inquisitive logic can be characterized by a Kripke model built up from D-substitutions. Additionally, we resolve a conjecture concerning superintuitionistic inquisitive logics due to Miglioli et al.. (shrink)

Theodor W. Adorno, one of the leading social thinkers of the twentieth century, long concerned himself with the problems of moral philosophy, or "whether the good life is a genuine possibility in the present." This book consists of a course of seventeen lectures given in May-July 1963. Captured by tape recorder, these lectures present a somewhat different, and more accessible, Adorno from the one who composed the faultlessly articulated and almost forbiddingly perfect prose of the works published in his lifetime. (...) Here we can follow Adorno's thought in the process of formation, endowed with the spontaneity and energy of the spoken word. The lectures focus largely on Kant, "a thinker in whose work the question of morality is most sharply contrasted with other spheres of existence." After discussing a number of the Kantian categories of moral philosophy, Adorno considers other, seemingly more immediate general problems, such as the nature of moral norms, the good life, and the relation of relativism and nihilism. In the course of the lectures, Adorno addresses a wide range of topics, including: theory and practice, ethics as bad conscience, the repressive character, the problem of freedom, dialectics in Kant and Hegel, the nature of reason, the moral law as a given, psychoanalysis, the element of the Absurd, freedom and law, the Protestant tradition of morality, _Hamlet,_ self-determination, phenomenology, the concept of the will, the idea of humanity, _The Wild Duck,_ and Nietzsche's critique of morality. (shrink)

The Dodd‐Frank Wall Street Reform and Consumer Protection Act, signed into law by President Obama in July 2010, included two significant corporate governance mandates: “say‐on‐pay” shareholder voting and the frequency of such votes among all publicly traded companies. The say‐on‐pay rule requires publicly traded companies subject to proxy rules to offer their shareholders an advisory, or nonbinding, vote at least once every three years on the compensation packages of the most highly compensated executives. The actual data for the first five (...) years of say‐on‐pay voting indicates one intractable conclusion: that shareholder say‐on‐pay voting has not verified what many shareholder activists originally believed, i.e., that the majority of shareholders held similar opinions about business executives being significantly overpaid for their managerial performances. During its first five years in effect, the results of say‐on‐pay voting indicate that shareholders are overwhelmingly satisfied with executive compensation packages, as a 92 percent average shareholder say‐on‐pay approval result (i.e., exceeding 70 percent) among companies listed in the Russell 3000 Index attests. (shrink)

In the paper, we study the dynamics of coalitional ability by proposing an extension of coalition logic (CL). CL allows one to reason about what a coalition of agents is able to achieve through a joint action, no matter what agents outside of the coalition do. The proposed dynamic extension is inspired by dynamic epistemic logic, and, in particular, by action models. We call the resulting logic coalition action model logic (CAML), which, compared to CL, includes additional modalities for coalitional (...) action models. We investigate the expressivity of CAML, and provide a complexity characterisation of its model checking problem. (shrink)