Autoantibodies to three eukaryotic 60S ribosomal phosphoproteins P0, P1 and P2 have been found in the sera of 10–20% of patients with systemic lupus erythematosus (SLE). These three proteins share a common epitope contained within the carboxy terminal 22 amino acids of each protein. Because central nervous system disturbances, with major behavioural disorders, occur in a significant fraction of SLE patients, the antiribosomal autoantibodies were measured in this subset of SLE individuals to determine whether or not there was an association. (...) This antibody is present in 90% of SLE patients who were diagnosed as having psychosis, secondary to the disease. (shrink)

The nature/nurture debate is not dead. Dichotomous views of development still underlie many fundamental debates in the biological and social sciences. Developmental systems theory offers a new conceptual framework with which to resolve such debates. DST views ontogeny as contingent cycles of interaction among a varied set of developmental resources, no one of which controls the process. These factors include DNA, cellular and organismic structure, and social and ecological interactions. DST has excited interest from a wide range of researchers, from (...) molecular biologists to anthropologists, because of its ability to integrate evolutionary theory and other disciplines without falling into traditional oppositions. The book provides historical background to DST, recent theoretical findings on the mechanisms of heredity, applications of the DST framework to behavioral development, implications of DST for the philosophy of biology, and critical reactions to DST. (shrink)

Sweeping in scope, penetrating in analysis, and generously illustrated with examples from the history of science, this new and original approach to familiar questions about scientific evidence and method tackles vital questions about science and its place in society. Avoiding the twin pitfalls of scientism and cynicism, noted philosopher Susan Haack argues that, fallible and flawed as they are, the natural sciences have been among the most successful of human enterprises-valuable not only for the vast, interlocking body of knowledge (...) they have discovered, and not only for the technological advances that have improved our lives, but as a manifestation of the human talent for inquiry at its imperfect but sometimes remarkable best. This wide-ranging, trenchant, and illuminating book explores the complexities of scientific evidence, and the multifarious ways in which the sciences have refined and amplified the methods of everyday empirical inquiry; articulates the ways in which the social sciences are like the natural sciences, and the ways in which they are different; disentangles the confusions of radical rhetoricians and cynical sociologists of science; exposes the evasions of apologists for religious resistance to scientific advances; weighs the benefits and the dangers of technology; tracks the efforts of the legal system to make the best use of scientific testimony; and tackles predictions of the eventual culmination, or annihilation, of the scientific enterprise. Writing with verve and wry humor, in a witty, direct, and accessible style, Haack takes readers beyond the "Science Wars" to a balanced understanding of the value, and the limitations, of the scientific enterprise. (shrink)

Forthright and wryly humorous, philosopher Susan Haack deploys her penetrating analytic skills on some of the most highly charged cultural and social debates of recent years. Relativism, multiculturalism, feminism, affirmative action, pragmatisms old and new, science, literature, the future of the academy and of philosophy itself—all come under her keen scrutiny in _Manifesto of a Passionate Moderate_. "The virtue of Haack's book, and I mean _virtue_ in the ethical sense, is that it embodies the attitude that it exalts... Haack's (...) voice is urbane, sensible, passionate—the voice of philosophy that matters. How good to hear it again."—Jonathan Rauch, _Reason_ "A tough mind, confident of its power, making an art of logic... a cool mastery."—Paul R. Gross, _Wilson Quarterly_ "Few people are better able to defend the notion of truth, and in strong, clear prose, than Susan Haack... a philosopher of great distinction."—Hugh Lloyd-Jones, _National Review_ "If you relish acute observation and straight talk, this is a book to read."—_Key Reporter_ "Everywhere in this book there is the refreshing breeze of common sense, patiently but inexorably blowing."—Roger Kimball, _Times Literary Supplement_ "A refreshing alternative to the extremism that characterizes so much rhetoric today."—_Kirkus Reviews_. (shrink)

In this book, Sara Monoson challenges the longstanding and widely held view that Plato is a virulent opponent of all things democratic. She does not, however, offer in its place the equally mistaken idea that he is somehow a partisan of democracy. Instead, she argues that we should attend more closely to Plato's suggestion that democracy is horrifying and exciting, and she seeks to explain why he found it morally and politically intriguing.Monoson focuses on Plato's engagement with democracy as he (...) knew it: a cluster of cultural practices that reach into private and public life, as well as a set of governing institutions. She proposes that while Plato charts tensions between the claims of democratic legitimacy and philosophical truth, he also exhibits a striking attraction to four practices central to Athenian democratic politics: intense antityrantism, frank speaking, public funeral oratory, and theater-going. By juxtaposing detailed examination of these aspects of Athenian democracy with analysis of the figurative language, dramatic structure, and arguments of the dialogues, she shows that Plato systematically links democratic ideals and activities to philosophic labor. Monoson finds that Plato's political thought exposes intimate connections between Athenian democratic politics and the practice of philosophy.Situating Plato's political thought in the context of the Athenian democratic imaginary, Monoson develops a new, textured way of thinking of the relationship between Plato's thought and the politics of his city. (shrink)

The Physician Payments Sunshine Act requires health care product manufacturers to report to the federal government payments more than $10 to physicians. Bringing unprecedented transparency to medicine, PPSA holds great potential for enabling medical stakeholders to manage conflicts of interest and build patient trust—crucial responsibilities of medical professionalism. The authors conducted six focus groups with 42 physicians in Chicago, IL, San Francisco, CA, and Washington, DC, to explore attitudes and experiences around PPSA. Participants valued the concept of transparency but were (...) wary of the law's design and consequences. They downplayed PPSA's potential and felt it undermined public trust. Showing broad unawareness of COI, they dismissed the notion of industry influence and welcomed company “perks.” Misapprehensions may leave physicians unprepared to advance the opportunities PPSA holds for professionalism. The authors offer recommendations for government and medicine to improve physicians' and other stakeholders' understandings and use of the data. (shrink)

While information technologies present organizations with opportunities to become more competitive, unsettled social norms and lagging legislation guiding the use of these technologies present organizations and individuals with ethical dilemmas. This paper presents two studies investigating the relationship between intellectual property and privacy attitudes, Machiavellianism and Ethical Ideology, and working in R&D and computer literacy in the form of programming experience. In Study 1, Machiavellians believed it was more acceptable to ignore the intellectual property and privacy rights of others. Programmers (...) and R&D workers considered violating intellectual property rights more acceptable. Programmers did not consider violating privacy rights more acceptable, but R&D workers did. Finally, there was an interaction between Machiavellianism, programming and R&D. Machiavellians who also had programming experience or worked in R&D found violations of intellectual property much more acceptable. The effect of Machiavellianism on attitudes toward violations of privacy was enhanced by working in R&D, but not by programming experience. In Study 2, idealists believed it was less acceptable to ignore the intellectual property and privacy rights of others. Relativists found it more acceptable to violate intellectual property rights, though they did not consider it more acceptable to violate privacy rights. Those with programming experience were more accepting of intellectual property rights violations, but not of privacy violations. Finally, programming experience moderated the relationship between idealism, relativism and attitudes toward these unethical information practices. Implications for diminishing unethical behavior among Machiavellians, Relativists, programmers and those in R&D are discussed. (shrink)

This paper argues that the various approaches to ethics that bioethicists rely on are not adequate to provide effective moral guidance in how to avoid a series of looming human catastrophes (associated with such threats as environmental degradation, war, extreme poverty, and pandemics). It proposes development of a new approach to ethics, dubbed public ethics, that simultaneously investigates moral responsibilities at multiple levels of human organization from the individual to international bodies. It argues that feminist relational theory can provide guidance (...) to development of this new type of ethics, and it warns against obstacles bioethicists face in its pursuit. (shrink)

A Teacher's Manual for this book will be available online at www.temple.edu/tempress.

The rhetoric of reconciliation is common in situations where traditional judicial responses to past wrongdoing are unavailable because of corruption, large numbers of offenders, or anxiety about the political consequences. But what constitutes reconciliation?

Conversations on Consciousness is just that - a series of twenty lively and challenging conversations between Sue Blackmore and some of the world's leading philosophers and scientists. Written in a colloquial and engaging style the book records the conversations Sue had when she met these influential thinkers, whether at conferences in Arizona or Antwerp, or in their labs or homes in Oxford or San Diego. The conversations bring out their very different personalities and styles and reveal a wealth of fascinating (...) detail about their theories and beliefs. Why is consciousness such a special and difficult issue for twenty-first century science? Sue, herself a researcher into this controversial and difficult topic, begins by asking each of her colleagues this simple question and is immediately plunged into the depths of the debate: How do the subjective experiences we call consciousness arise from the physical brain? Is this even the right question to ask? Can zombies - people who behave outwardly just like others but have no inner mental life - exist? What can dreams tell us about consciousness? Should we all be learning to meditate? Do we have free will, and if not is it possible to live without it? With an introduction setting out the broad structure of the debate on consciousness, and an extensive glossary, this book provides an engaging and accessible account of the most challenging problem of all, through the words of some of the leading figures involved in seeking to solve it. (shrink)

This collection of thirteen new essays is the first to examine, from a range of disciplinary perspectives, how the new technologies and global reach of the Internet are changing the theory and practice of free speech.

Just as a stream of genetically modifiedcrops looked set to be approved for commercialproduction in the European Union, the approvalprocedure appears to have become bogged down onceagain by disagreements among and within member states.Old controversies have resurfaced in new forms. Theintractability of the issues suggests that theregulatory procedure has had too narrow a focus,leaving outside its boundary many of the morefundamental aspects that cause people in the EuropeanUnion most concern. Regulators have come underconsiderable pressure to ensure their risk assessmentdecisions are (...) soundly science-based. Ethical issueshave been deemed to lie beyond the scope of theregulatory procedure, as a matter to be consideredseparately by professional ethicists. Yet it has beensuggested that all environmental controversies at rootinvolve disputes about fundamental ethical principles.This paper examines how the ethical issues arecurrently suppressed or sidelined. It discusses how anappreciation of systems thinking and a check on thevalues that underpin decisions, using boundary testingquestions, might contribute to a more constructiveregulatory dialogue, with ethical issues considered asintegral in a way that takes better account ofpeople's concerns. (shrink)

Demonstrates the unique, pervasive, and overwhelmingly important role of other people within our lived experience. Drawing on the original phenomenological work of Maurice Merleau-Ponty, Edmund Husserl, Simone de Beauvoir, and John Russon, as well as recent research in child psychology, The Other in Perception argues for perception’s inherently existential significance: we always perceive a world and not just objective facts. The world is the rich domain of our personal and interpersonal lives, and central to this world is the role of (...) other people. We are “paired” with others such that our perception is really the enactment of a coinhabiting of a shared world. These relations with others shape the very way in which we perceive our world. Susan Bredlau explores two uniquely formative domains in which our pairing relations with others are particularly critical: childhood development and sexuality. It is through formative childhood experience that the essential, background structures of our world are instituted, which has important consequences for our developed perceptual life. Sexuality is an analogous domain of formative intersubjective experience. Taken as a whole, Bredlau demonstrates the unique, pervasive, and overwhelmingly important role of other people within our lived experience. (shrink)

From my Consciousness in Action, ch. 2; see Consciousness in Action for bibligraphy. This chapter revises material from "Kant on Spontaneity and the Myth of the Giving", Proceedings of the Aristotelian Society, 1993-94, pp. 137-164, and "Myth Upon Myth", Proceedings of the Aristotelian Society, 1996, vol. 96, pp. 253-260.

Pragmatism and Justice is an interdisciplinary volume of new and seminal essays by political philosophers, social theorists, and scholars of pragmatism which provides a comprehensive introduction and lasting resource for scholars of pragmatist thought and questions of justice.

The doctrine of abstract ideas contains Locke’s views on the nature of generality and how we think in general terms-the nature of universals, of general concepts, and how we classify. While Reid rejects abstract ideas, he accepts Locke’s insight that we have an ability to abstract. In this paper, I show how Reid preserves Locke’s insight, while providing a more versatile and forward-looking account of universals and concepts than Locke was able to give.Reid replaces abstract ideas with what he calls (...) “general conceptions.” But general conceptions are really three different things. First, they are universals---non-mental intrinsically general objects of acts of abstraction and conception. I show how Reid is able to make the claim that there are universals without being committed to holding that universals really exist. This claim, together with his type/token distinction, enables Reid to better explain how we have knowledge of attributes and use general terms meaningfully. The general features of our experience are not ideas and are not produced by the faculty of abstraction---but that faculty enables us to distinguish them.In the second sense, a general conception is an act of mind which takes universals as objects. Thinking in general tenns is not the manipulation of abstract ideas---it is engaging in acts of conceiving. Such acts are made possible by general conceptions in the third sense, namely, general concepts. While Reid does not distinguish this sense explicitly, I argue that he takes general concepts to be dispositions or abilities to distinguish general features of objects and to use the general terms of language as other users do. So rather than producing mental entities---abstract ideas---that act as standards to help us classify, abstraction makes possible the development of abilities to use general terms and classify objects. (shrink)

Quine and Putnam argued for mathematical realism on the basis of the indispensability of mathematics to science. They claimed that the mathematics that is used in physical theories is confirmed along with those theories and that scientific realism entails mathematical realism. I argue here that current theories of confirmation suggest that mathematics does not receive empirical support simply in virtue of being a part of well confirmed scientific theories and that the reasons for adopting a realist view of scientific theories (...) do not support realism about mathematical entities, despite the use of mathematics in formulating scientific theory. (shrink)

Name der Zeitschrift: Semiotica Jahrgang: 2016 Heft: 213 Seiten: 247-279.

Successful preimplantation genetic diagnosis to avoid creating a child affected by a genetically-based disorder was reported in 1989. Since then PGD has been used to biopsy and analyze embryos created through in viuo fertilization to avoid transferring to the mother’s uterus an embryo affected by a mutation or chromosomal abnormality associated with serious illness. PGD to avoid serious and early-onset illness in the child-to-be is widely accepted. PGD prevents gestation of an affected embryo and reduces the chance that the parents (...) will be faced with a difficult decision of whether to terminate the pregnancy. More controversial have been PGD to select the sex of the child-to-be for “family balancing”, PGD for mere susceptibility to disease and for late-onset disorders such as Alzheimer diseas, and most controversially, PGD to create a donor child who is Human Leukocyte Antigen (HLA-matched with a preexisting sibling in need of stem cell transplant. (shrink)

Our urban problem is how to revive the reality of the outside as a dimension of human experience.Richard Sennett.

Clinical ethics, like the broader field of bioethics from which it emerged, is at a critical crossroads in its development, with conflicting paths ahead. It can either claim its distinctive place in the clinical arena, insisting unapologetically on certain minimal standards of professional training, practice and competence, addressing head on debates about various models of and methodological approaches to consultation, and establishing a shared vision of the purpose and meaning of the enterprise of clinical ethics itself. Or, it can devolve (...) into a hobby that untrained, albeit interested, and generally well intentioned individuals can dabble in for fun or even profit, as they see fit, and without regard to the deep history and rich disciplinary roots of the field, the serious debates in the academic literature of bioethics, the foundational case histories and legal theories, or even any sense of professional accountability. (shrink)

In this article, I argue that queer women – especially cis and trans lesbians – have more in common than contemporary fissures either allow for or acknowledge. Lesbians who recognised their queer sexuality in the 1970s have in common with trans women the shared condition of being, in the words of the 1970s radical feminist Marilyn Frye, ‘spat summarily out of reality’. We also share the experience of refusing to accept this condition. I make this argument by manoeuvring away from (...) questions of gender identity and focusing instead on gender’s ontoformativity: the astonishing, welcome and transformative fact that new social realities are brought into being by new social practices. I turn to experimental writing to explore this matter. Through this medium, the cis lesbian poet Nicole Brossard and the trans lesbian poet Trace Peterson wrote themselves into worlds, languages and social orders that refused to acknowledge their existence. Brossard was writing in 1970s Montreal, Peterson in early twenty-first-century New York, but what they have in common, indeed what radical lesbian theory from the 1970s shares with contemporary theorising by trans women, is the insight that identifying with men is expected. It is in identifying with women that we are most at risk. (shrink)

Where research was once strictly confined to one laboratory or office, investigators now widely share and compare their plans, analyses, and results. With the advent of genomic knowledge, researchers are seeking to understand the genetics and genomics of complex human disease. They are combining their efforts into international consortia in order to take on problems that face individuals around the world, such as cancer and malaria — problems that are too large to solve by one country alone. These consortia bring (...) together diverse research groups from different parts of the world to focus on a common goal. Their projects may all focus on one disease or condition, but examine it from different perspectives and share the newly gained information with each other and the wider scientific community. (shrink)

The thesis of this paper encapsulates the deep suspicion postcolonial theory has of privileged identity claims while ignoring the manner in which identity is negotiated in a postcolonial context. The limits of identity claims with regard to theology and ethics is analyzed through Rahner’s presentation of “Indifferent Freedom” and its impact on gendered subalterns. A feminist postcolonial theological anthropology rejects the dehumanizing consequences of Rahner’s move to condone violence in the face of force in the world. What is needed rather, (...) is a non-violent and embodied response in the face of violence, initiated by the gendered subaltern, which simultaneously captures Rahner’s original intention of linking spirituality to ethics. Gayatri C. Spivak’s notion of the caress to interrupt the dehumanized discourses of exploitation and unequal power is forwarded as the way to being human in the postcolonial context, in order to make Rahner’s theology and spirituality more concrete for postcolonial societies. (shrink)

The human sensory system is continuously engaged in experiencing and interpreting every interaction with other living beings, objects, and the environment. The purpose of this article is to describe the impact limited opportunities for rich sensory experiences have on students with severe disabilities in two middle school classrooms situated in a public separate school in the southeastern USA. The study employed a postcritical ethnographic approach and grounded theory thematic analysis of fieldnotes gathered over a two-year period. Three major themes supported (...) by the data are presented and discussed in depth. They are: students are afforded limited sensory rich experiences, everyday routines make students passive recipients to school, and instructional approaches result in little interaction with extended periods of waiting. The implications of the findings for improved sensory experiences and possible future directions are described. (shrink)