Cancers rely on multiple, heterogeneous processes at different scales, pertaining to many biomedical fields. Therefore, understanding cancer is necessarily an interdisciplinary task that requires placing specialised experimental and clinical research into a broader conceptual, theoretical, and methodological framework. Without such a framework, oncology will collect piecemeal results, with scant dialogue between the different scientific communities studying cancer. We argue that one important way forward in service of a more successful dialogue is through greater integration of applied sciences (experimental and clinical) (...) with conceptual and theoretical approaches, informed by philosophical methods. By way of illustration, we explore six central themes: (i) the role of mutations in cancer; (ii) the clonal evolution of cancer cells; (iii) the relationship between cancer and multicellularity; (iv) the tumour microenvironment; (v) the immune system; and (vi) stem cells. In each case, we examine open questions in the scientific literature through a philosophical methodology and show the benefit of such a synergy for the scientific and medical understanding of cancer. (shrink)

My aim in this paper is to elucidate Leibniz’s account of moral normativity and the relation between motivation and obligation. I argue against the recent interpretation of Christopher Johns, according to which Leibniz’s moral theory is actually a deontological theory, having more in common with Kantian moral theory than with any form of consequentialism. I argue that for Leibniz reason is not itself the source of practical normativity and real obligation; the source of that is rather the agent’s desire for (...) his own happiness or perfection. For Leibniz, reason in its practical role functions instrumentally: the desire for one’s own happiness is the source of practical normativity, and reason functions only to transfer that normativity from the end that it does not determine to the means to those ends that it does determine. (shrink)

One argument that Leibniz employed to rule out the possibility of a world soul appears to turn on the assumption that the very notion of an infinite number or of an infinite whole is inconsistent. This argument was considered in a series of three papers published in The Leibniz Review: in the first, by Laurence Carlin, the argument was delineated and analyzed; in the second, by myself, the argument was criticized and rejected; in the third, by Richard Arthur, an attempt (...) was made to defend Leibniz’s argument against my criticisms. In the present paper, I take up the matter again in an attempt to clarify the issues involved and to defend my original criticisms of the argument against the objections raised by Arthur. (shrink)

"The documents gathered in this volume cut a winding path through the tumultuous final thirty-three months of Leibniz's life, from March 1714 to his death on 14 November 1716. The disputes with Newton and his followers over the discovery of the calculus and, later, over the issues in natural philosophy and theology that came to dominate Leibniz's correspondence with Samuel Clarke certainly loom large in the story of these years. But as the title of this volume is intended to convey, (...) the letters exchanged between Leibniz and Caroline of Brandenburg-Ansbach, Electoral Princess of Braunschweig-Luneburg and later Princess of Wales, also figure prominently in their telling, and I have included their complete extant correspondence from 1714 to 1716. These letters are of particular interest inasmuch as they provide valuable insights into how and why Leibniz's correspondence with Clarke arose, and why it developed as it did, with Caroline in the role of influential go-between; whence the title, The Leibniz-Caroline-Clarke Correspondence. But there is more; for these letters provide a window into the evolving personal relationship between Leibniz and Caroline. Much of the early correspondence between Leibniz and Caroline after her arrival in England is filled with thoughtful and engaging exchanges about philosophy, literature, and politics, about people Caroline was meeting in England, about those known by Leibniz far and wide, about the new royal family in England, headed by George I (Georg Ludwig of Braunschweig-Luneburg), as well as gossip about affairs of state in both England and Europe at large. Beyond the interest they hold for Leibniz scholars in particular, many of these exchanges should also be of interest to historians of early 18th-century England and Europe, and especially to those interested in the period immediately preceding and following the Hanoverian succession to the throne of England. But even quite early on in their correspondence Leibniz seemed to sense a threat to his relationship with Caroline, and a worrisome paranoia began to creep into some of his letters to her, letters in which he expressed concerns about her continuing allegiance to him now that she had been installed in England amongst his rivals. As the correspondence progressed, Leibniz's paranoia only deepened; but it was nevertheless prophetic of a tragic truth to come. For the letters exchanged between Leibniz and Caroline document the rather sad story of the slow but steady erosion of Caroline's loyalty to Leibniz after she departed Hanover on 12 October 1714 and landed in England at Margate in Kent on 22 October as the new Princess of Wales and future Queen of England. In 1727 the Scottish poet James Thomson penned A Poem Sacred to the Memory of Sir Isaac Newton, calling him "our philosophic sun," and it was by force of the political and cultural mass of this sun that Caroline was eventually, and inexorably, drawn into its orbit, and away from Leibniz". (shrink)

In 1676 Leibniz reluctantly left Paris, headed for Hanover, to take up the position of counselor and librarian to Johann Friedrich, duke of Brunswick—Lüneburg—Calenberg. He was to remain in the employ of a succession of dukes and electors of Hanover—the last being Georg Ludwig, who became George I of England in 1714—until his death in November 1716. During this time he also became a familiar at the court in Berlin of the elector of Brandenburg (later King of Prussia) and at (...) the imperial court in Vienna. This paper traces the important relationships that developed between Leibniz and a number of the ladies of these courts. (shrink)

While he was in the employ of the Elector of Mainz, between 1668 and 1671, Leibniz produced a series of important studies in natural law. One of these, dated between 1670 and 1671, is especially noteworthy since it contains Leibniz's earliest sustained attempt to develop an account of justice. Central to this account is the notion of what Leibniz would later come to call `disinterested love', a notion that remained essentially unchanged in Leibniz's work from this period to the end (...) of his life. Through his notion of disinterested love, Leibniz sought to resolve the supposed conflict between self- and other-regarding motives. For a variety of reasons, many commentators have failed to understand the basis of Leibniz's proposed resolution. My purpose in the present paper is to clarify the terms in which Leibniz effected this resolution, as well as to point out important developments in his later thought concerning the relation between pleasure, good, and happiness. (shrink)

One argument that Leibniz employed to rule out the possibility of a world soul appears to turn on the assumption that the very notion of an infinite number or of an infinite whole is inconsistent. This argument was considered in a series of three papers published in The Leibniz Review: in the first, by Laurence Carlin, the argument was delineated and analyzed; in the second, by myself, the argument was criticized and rejected; in the third, by Richard Arthur, an attempt (...) was made to defend Leibniz’s argument against my criticisms. In the present paper, I take up the matter again in an attempt to clarify the issues involved and to defend my original criticisms of the argument against the objections raised by Arthur. (shrink)

In the first section of this paper I discuss what Leibniz meant by a miracle and why Leibniz’s definition of the best of all possible worlds implies that it is a world in which miracles are minimized. In the second part of the paper I argue that human happiness within the best of all possible worlds also requires, on Leibniz’s principles, that miracles must there be minimized. In the third section of the paper I consider what, if any, miracles actually (...) remain possible for Leibniz within the best of all possible worlds. In the final section I discuss one important kind of event upon which Leibniz vacillated whether it required miraculous intervention -- namely, the elevation of the sensitive soul to rationality -- and some speculation about the cause of this vacillation in Leibniz is offered. (shrink)

In this book Gregory Browne rejects the views of David Hume and the Logical Positivists, and argues that there are necessary factual truths, which include a wide range of truths from many fields of knowledge. Browne argues for the necessity of Newton's Laws and truths about natural kinds, and for the factuality of definitional truths and truths of logic and mathematics. Browne synthesizes the work of Kripke, Putnam, Quine and others, but goes beyond the usual discussions of the meanings (...) and definitions of terms to discuss the references of various kinds of terms, and specifically to develop a theory of kinds, distinguishing 'Deep Kinds' and 'Shallow Kinds' . His theory of Deep Kinds does not accept all of the assumptions commonly associated wtih a theory of natural kinds. (shrink)

In this paper I wish to examine the nature and role of "the phenomena of God" in Leinbiz's mature thought. In the first part of the paper, I discuss the nature of the universal harmony and argue that they are the perceptiual states of finite substances and the relations among them that constitute God's phenomena. In the second part of the paper, I attempt to specify the theoretical role that God's phenomena play in Leibniz's phenomenalism. This leads finally to a (...) discussion of Leibniz's teleological reasoning in the investigation of nature and of how that justification undercuts the argument for God's existence from the pre-established harmony. (shrink)

I undertake to examine how Descartes understood the relationship between physics and mathematics. My thesis is that what distinguishes the objects of mathematics from those of physics on Descartes's view is that the former are considered in abstraction from a material substratum while the latter are considered as involving a material substratum. Since it has often been maintained that Descartes identified matter with extension, and hence rejected the notion of a material substratum, I attempt in the first part of my (...) paper to establish the textual basis for ascribing a substratum view to Descartes. In the second part of the paper, I present the case for my thesis concerning Descartes's account of the difference between the objects of mathematics and those of physics. (shrink)

This is a superbly crafted and exhaustively researched account of the development of Leibniz’s thought, his ambitious plans and undertakings, his myriad intellectual engagements, and his ceaseless comings and goings across Europe. It captures, accurately and in great detail, the remarkably expansive mind of a singularly creative thinker. It is an extraordinary achievement, for the task of writing an intellectual biography of Leibniz is huge. To read even a portion of what he wrote and read, in the languages in which (...) he wrote and read it, to come to grips with the nuances of religion, politics, and intellectual practice that define his world, and to identify the hundreds of individuals, illustrious and forgotten, with whom he interacted would challenge even the most skilled and dedicated scholar. There is no doubt that Antognazza has met this challenge with a biography that surpasses any available account of Leibniz’s life.The book is divided into three parts. A brief introduction surveys past attempts at capturing the breadth of Leibniz’s thought and articulates “four basic, underlying theses” that unify the chapters to follow. They are: first, that Leibniz’s life and work need to be assessed as a whole as opposed to focusing narrowly on his contributions to one or another field; second, that Leibniz’s life and thought are integrated to a remarkable degree and that it is a mistake to. (shrink)

The U.S. and Canadian health care systems are more similar than is commonly believed. This article debunks some of the powerful myths about these health care systems and opens up the discussion for greater policy learning from both sides of the border. Cross-border comparisons can yield a number of lessons from common policy challenges such as cost control, physician organization and payment, and the organization of health coverage and services for Native Americans and Indigenous Canadians.

White matter tracts are known to be susceptible to injury following concussion. The objective of this study was to determine whether contact play in sport could alter white matter metabolite levels in female varsity athletes independent of changes induced by long-term exercise. Metabolite levels were measured by single voxel proton magnetic resonance spectroscopy in the prefrontal white matter at the beginning and end of season in contact and non-contact varsity athletes. Sedentary women were scanned once, at a time equivalent to (...) the Off-Season time point. Metabolite levels in non-contact athletes did not change over a season of play, or differ from age matched sedentary women except that non-contact athletes had a slightly lower myo-inositol level. The contact athletes had lower levels of myo-inositol and glutamate, and higher levels of glutamine compared to both sedentary women and non-contact athletes. Lower levels of myo-inositol in non-contact athletes compared to sedentary women indicates long-term exercise may alter glial cell profiles in these athletes. The metabolite differences observed between contact and non-contact athletes suggest that non-contact athletes should not be used as controls in studies of concussion in high-impact sports because repetitive impacts from physical contact can alter white matter metabolite level profiles. It is imperative to use athletes engaged in the same contact sport as controls to ensure a matched metabolite profile at baseline. (shrink)

End-of-life decision making is fraught with ethical challenges. Withholding or withdrawing life support therapy is widely considered ethical in patients with high treatment burden, poor premorbid status, or significant projected disability even when such treatment is not “futile.” Whether such withdrawal of therapy in the aftermath of attempted suicide is ethical is not well established in the literature. We provide a clinical vignette and propose criteria under which such withdrawal would be ethical. We suggest that it is appropriate to withdraw (...) life support, regardless of the cause of the critical illness or disability, when the following criteria are met: (1) Surrogates request withdrawal of care and the adequacy of surrogates is confirmed, (2) an external reasonability standard is met, (3) passage of time, perhaps 72 hours, to allow certainty regarding the patient's wishes, and (4) psychiatric morbidity should be considered as grounds for withdrawal only in truly treatment-refractory cases. Fundamentally, we believe the question to ask is, “If this were not an attempted suicide, would a request to withdraw care be reasonable?” We believe that under these circumstances, such withdrawal of life support, even in an individual who has attempted suicide, does not constitute physician assistance with suicide and is distinct from physician aid-in-dying in several important respects. (shrink)

This volume brings together a number of original articles by leading Leibniz scholars to address the meaning and significance of Leibniz’s notions of compossibility and possible worlds. In order to avoid the conclusion that everything that exists is necessary, or that all possibles are actual, as Spinoza held, Leibniz argued that not all possible substances are compossible, that is, capable of coexisting. In Leibniz’s view, the compossibility relation divides all possible substances into disjoint sets, each of which constitutes a possible (...) world, or a way that God might have created things. For Leibniz, then, it is the compossibility relation that individuates possible worlds; and possible worlds form the objects of God’s choice, from among which he chooses the best for creation. Thus the notions of compossibility and possible worlds are of major significance for Leibniz’s metaphysics, his theodicy, and, ultimately, for his ethics. Given the fact, however, that none of the approaches to understanding Leibniz’s notions of compossibility and possible words suggested to date have gained universal acceptance, the goal of this book is to gather a body of new papers that explore ways of either refining previous interpretations in light of the objections that have been raised against them, or ways of framing new interpretations that will contribute to a fresh understanding of these key notions in Leibniz’s thought. (shrink)

End-of-life decision making is fraught with ethical challenges. Withholding or withdrawing life support therapy is widely considered ethical in patients with high treatment burden, poor premorbid status, or significant projected disability even when such treatment is not ?futile.? Whether such withdrawal of therapy in the aftermath of attempted suicide is ethical is not well established in the literature. We provide a clinical vignette and propose criteria under which such withdrawal would be ethical. We suggest that it is appropriate to withdraw (...) life support, regardless of the cause of the critical illness or disability, when the following criteria are met: (1) Surrogates request withdrawal of care and the adequacy of surrogates is confirmed, (2) an external reasonability standard is met, (3) passage of time, perhaps 72 hours, to allow certainty regarding the patient's wishes, and (4) psychiatric morbidity should be considered as grounds for withdrawal only in truly treatment-refractory cases. Fundamentally, we believe the question to ask is, ?If this were not an attempted suicide, would a request to withdraw care be reasonable?? We believe that under these circumstances, such withdrawal of life support, even in an individual who has attempted suicide, does not constitute physician assistance with suicide and is distinct from physician aid-in-dying in several important respects. (shrink)

These essays apply influential, pathbreaking psychological studies about women's lives to literature. In their analyses of fictional portraits, contributors both challenge and confirm psychological theories about female identity, about 'connection/separation' as developmental catalysts, and about the impact of gender on 'voice,' moral decision-making, and epistemology in relation to classical and contemporary literary texts, written by both women and men.

I highly recommend reading Gregory S. Moss’ Hegel's Foundation Free Metaphysics: The Logic of Singularity. In this detailed examination of Hegel's masterpiece.

In On the Soul and the Resurrection, St Macrina and St Gregory of Nyssa consider what the soul is, and its relationship to our body and identity. Gregory notes the way that our bodies are always changing, and asks which is most truly our ‘real’ body if we are always in a state of growth, decay and transience? What physical body will be with us at the resurrection? If our body is as important to our identity as our (...) soul, then who am I when my body changes? Macrina answers that our identity is bodily, but that the sufferings and passages of time that alter our bodies mean that we are an imperfect version of ourselves in this life. The person that we will be at the resurrection will be free from the influence of evil and the ravages of impermanence. Modern-day science fiction wrestles with Gregory’s problem—where is my identity located? If my body is altered beyond recognition, or my mind transferred to a new body, am I still me? These cyberpunk and transhumanist worries call to mind the ancient topic of mind/body dualism, and Macrina and Gregory have some surprisingly relevant insights to offer to our contemporary technological dilemmas. (shrink)

The infancy narratives of Matthew and Luke pose in an acute form the question of the historical value of the Gospels. Raymond Brown suggests that redaction criticism can bypass this question by spelling out the theological message intended by the evangelists. But his own exegesis suggests this is to misunderstand the genre of this literature. Brown’s indifference to historicity would be justified only if the evangelists were writing something resembling allegory, a form of narrative in which the literal sense of (...) the story is the clothing of a spiritual message. But Brown’s exegesis suggests that the evangelists do not regard the literal sense of these stories as dispensable; they regard their theological message as resting on a foundation of historical fact. It follows that if interpreters focus on the intention of the evangelists, they cannot avoid addressing the question of historicity. (shrink)

I argue that Christian apophaticism provides the most powerful and economical response to the evidential argument from evil for the non-existence of God. I also reply to the objection that Christian apophaticism is incoherent, because it appears to entail the truth of the following contradiction: it is both possible and impossible to know God’s essential properties. To meet this objection, I outline a coherent account of the divine attributes inspired by the theology of the Greek Father’s and St. Gregory (...) Palamas. (shrink)

Textbook Islam, nation building, and the question of violence / Gregory Starrett and Eleanor Abdella Doumato -- Egypt : promoting tolerance, defending against Islamism / James A. Toronto and Muhammad S. Eissa -- Iran : a Shi'ite curriculum to serve the Islamic state / Golnar Mehran -- Jordan : prescription for obedience and conformity / Betty Anderson -- Kuwait : striving to align Islam with Western values / Taghreed Alqudsi-Ghabra -- Oman : cultivating good citizens and religious virtue / (...) Mandana E. Limbert -- The Palestinian national authority : the politics of writing and interpreting curricula. Genesis of a new curriculum / Nathan Brown ; A conflict of historical narratives / Seif Da'Na -- Saudi Arabia : from "Wahhabi" roots to contemporary revisionism / Eleanor Abdella Doumato -- Syria : secularism, Arabism, and Sunni orthodoxy / Joshua Landis -- Turkey : sanctifying a secular state / Ozlem Altan -- Textbook meanings and the power of interpretation / Gregory Starrett -- Conclusion : tailor-made Islam / Eleanor Abdella Doumato and Gregory Starrett. (shrink)

While regarding Gregory M. Browne as mainly on target in his Rand-inspired treatment of reference and necessity, as well as in his rejection of the analyticsynthetic dichotomy, Long argues, first, that Browne is mistaken in rejecting some other vital distinctions, such as the a priori / a posteriori distinction; second, that Browne is nevertheless implicitly committed, under different terminology, to these very distinctions that he purportedly rejects; and third, that Browne's treatment of kinds and definitions leads him to misdescribe (...) and misprescribe ordinary language use, and also to embrace unnecessary semantic incommensurability. (shrink)

Much philosophical attention has been devoted to “The Land Ethic,” especially by Anglo-American philosophers, but little has been paid to A Sand County Almanac as a whole. Read through the lens of continental philosophy, A Sand County Almanac promulgates an evolutionary-ecological world view and effects a personal self- and a species-specific Self-transformation in its audience. It’s author, Aldo Leopold, realizes these aims through descriptive reflection that has something in common with phenomenology-although Leopold was by no stretch of the imagination a (...) phenomenologist. Consideration of human-animal intersubjectivity, thematized in A Sand County Almanac, brings to light the moral problem of hunting and killing animal subjects. Leopold does not confront that problem, but it is confronted and resolved by Jose Ortega y Gassett, Henry Beston, and Paul Shepard in terms of an appropriate human relationship with wild-animal Others. Comparison with the genuinely Other-based Leopold-Ortega-Beston-Shepard wild-animal ethic shows the purportedly Other-based humanand possibly animal ethic of Emmanuel Levinas actually to be Same-based after all. (shrink)

Contemporary philosophical discourse has deeply problematized the possibility of absolute existence. Hegel’s Foundation Free Metaphysics demonstrates that by reading Hegel’s Doctrine of the Concept in his Science of Logic as a form of Absolute Dialetheism, Hegel’s logic of the concept can account for the possibility of absolute existence. Through a close examination of Hegel’s concept of self-referential universality in his Science of Logic, Moss demonstrates how Hegel’s concept of singularity is designed to solve a host of metaphysical and epistemic paradoxes (...) central to this problematic. He illustrates how Hegel’s revolutionary account of universality, particularity, and singularity offers solutions to six problems that have plagued the history of Western philosophy: the problem of nihilism, the problem of instantiation, the problem of the missing difference, the problem of absolute empiricism, the problem of onto-theology, and the third man regress. Moss shows that Hegel’s affirmation and development of a revised ontological argument for God’s existence is designed to establish the necessity of absolute existence. By adopting a metaphysical reading of Richard Dien Winfield’s foundation free epistemology, Moss critically engages dominant readings and contemporary debates in Hegel scholarship. Hegel’s Foundation Free Metaphysics will appeal to scholars interested in Hegel, German Idealism, 19th- and 20th-century European philosophy, metaphysics, epistemology, and contemporary European thought. (shrink)

In recent years serious attempts have been made to systematize and develop the moral and political themes of great philosophers of the past. Kant, Locke, Marx, and the classical utilitarians all have their current defenders and arc taken seriously as expositors of sound moral and political views. It is the aim of this book to introduce Hobbes into this select group by presenting a plausible moral and political theory inspired by Leviathan. Using the techniques of analytic philosophy and elementary game (...) theory, the author develops a Hobbesian argument that justifies the liberal State and reconciles the rights and interests of rational individuals with their obligations. Hobbes's case against anarchy, based on his notorious claim that life outside the political State would be a "war of all against all," is analyzed in detail, while his endorsement of the absolutist State is traced to certain false hypotheses about political sociology. With these eliminated, Hobbes's principles support a liberal redistributive State and a limited right of revolution. Turning to normative issues, the book explains Hobbes's account of morality based on enlightened self-interest and shows how the Hobbesian version of social contract theory justifies the political obligations of citizens of satisfactory States. (shrink)

In Dependent Rational Animals, Alasdair MacIntyre attempts to ground the virtues in a biological account of humans. Drawing from this attempt, he also tries to answer the question of why we should care for the severely disabled. MacIntyre’s difficulty in answering this question begins with the fact that his communities of practices do not naturally include the severely disabled within their membership and care. In response to this difficulty, he provides four reasons for why we should care for the severely (...) disabled. I argue that three of these reasons are inadequate, and that the fourth is incomplete although it does point in a promising direction. I conclude that a more satisfactory answer requires a further extension of the central development from After Virtue to Dependent Rational Animals, and I draw from Wendell Berry, whose work MacIntyre admires, to provide an illuminating illustration of what such an answer might look like. (shrink)

1. Hegel’s Doctrine of the Concept advances a theory of conceptual determinacy. As I will demonstrate, Hegel’s theory of conceptual determinacy leads him to endorse self-predication and existential...

In a well-known article, 1 John Hick argues that the proposition ‘God exists' is, in principle, verifiable but is not falsifiable. Essentially, his argument is that while no experience in this life could conclusively disprove the existence of the Christian God, certain experiences one might have in the after-life would conclusively verify the existence of the Christian God. In particular, he argues that post mortem experiences of Christ ruling in the Kingdom of God would constitute a verification of the existence (...) of the Christian God. In this paper, I shall argue that on Hick's own assumptions, the existence of the Christian God turns out to be falsifiable, in principle, as well as verifiable. (shrink)

Derrida defines différance as the “interruption of Hegelian dialectics.” Although scholars have noted that Derrida pursues his critique of Hegel by means of Hegelian concepts, the way that Derrida employs specific Hegelian concepts in his critique, such as non-positionality, self-reference, and contradiction, has not been sufficiently investigated. In this essay, I reconstruct Derrida’s critique of Hegel with special focus on the Hegelian concepts of non-positionality, self-reference, and contradiction.

It is, perhaps, a propitious time to discuss the economic rights of disabled persons. In recent years, the media in the United States have re-ported on such notable events as: students at the nation's only college for the deaf stage a successful protest campaign to have a deaf individual ap-pointed president of their institution; a book by a disabled British physicist on the origins of the universe becomes a best seller; a pitcher with only one arm has a successful rookie (...) season in major league baseball; a motion-picture actor wins an Oscar for his portrayal of a wheelchair-bound person, beating out another nominee playing another wheelchair-bound person; a cancer patient wins an Olympic gold medal in wrestling; a paralyzed mother trains her children to accept discipline by inserting their hands in her mouth to be gently bitten when punishment is due; and a paraplegic rock climber scales the sheer four-thousand-foot wall of Yosemite Valley's El Capitan. Most significantly, in 1990, the United States Congress passed an important bill – the Americans with Disabili-ties Act – extending to disabled people employment and access-related protections afforded to members of other disadvantaged groups by the Civil Rights Act of 1964. (shrink)