This article considers the reception of British cytogeneticist C.D. Darlington's controversial 1932 book, Recent Advances in Cytology. Darlington's cytogenetic work, and the manner in which he made it relevant to evolutionary biology, marked an abrupt shift in the status and role of cytology in the life sciences. By focusing on Darlington's scientific method -- a stark departure from anti-theoretical, empirical reasoning to a theoretical and speculative approach based on deduction from genetic first principles -- the article characterises (...) the relationships defining the "disciplinary landscape" of the life sciences of the time, namely those between cytology, genetics, and evolutionary theory. (shrink)

It has come to my attention that a number of formulations in the section “Disciplinary Landscape: Cytology and Genetics” of my article “Method as a Function of Disciplinary Landscape: C.D. Darlington and the History of Cytology 1925–1950,” Journal of the History of Biology, 39, 2006, pp. 165–197, do not provide due credit to a source. While Franz Schrader, “Three Quarter Centuries of Cytology,” Science 107 : 155–159, is cited in the article, his reminiscences and analysis of the historical development (...) of cytology provided a helpful historiographical context, as well as specific insights, for my article and should have been more fully acknowledged. (shrink)

This article considers the reception of British cytogeneticist C.D. Darlington's controversial 1932 book, Recent Advances in Cytology. Darlington's cytogenetic work, and the manner in which he made it relevant to evolutionary biology, marked an abrupt shift in the status and role of cytology in the life sciences. By focusing on Darlington's scientific method -- a stark departure from anti-theoretical, empirical reasoning to a theoretical and speculative approach based on deduction from genetic first principles -- the article characterises (...) the relationships defining the "disciplinary landscape" of the life sciences of the time, namely those between cytology, genetics, and evolutionary theory. (shrink)

This paper argues that the concept and role of ‘institutional racism’ in contemporary discussions of race should be reconsidered. It starts by distinguishing between ‘intrinsic institutional racism’, which holds that institutions are racist in virtue of their constitutive features, and ‘extrinsic institutional racism’, which holds that institutions are racist in virtue of their negative effects. It accepts intrinsic institutional racism, but argues that a ‘disparate impact’ conception of extrinsic conception faces a number of objections, the most serious being that it (...) has no plausible account of what it is that makes extrinsically racist institutions racist. It also argues that claims about the explanatory indispensability of institutional racism are overstated (individual racism is at least as important), critiques structural approaches to racial inequality, and suggests that there is reason to doubt whether institutional reform can provide us with all that morality may require in the racial domain. (shrink)

First published in 2000. Routledge is an imprint of Taylor & Francis, an informa company.

This article argues that blacks should reject integration on self-protective and solidarity grounds. It distinguishes two aspects of black devaluation: a ‘stigmatization’ aspect that has to do with the fact that blacks are subject to various forms of discrimination, and an aesthetic aspect (‘phenotypic devaluation’) that concerns the aesthetic devaluation of characteristically black phenotypic traits. It identifies four self-worth harms that integration may inflict, and suggests that these may outweigh the benefits of integration. Further, it argues that, while the integrating (...) process may reduce stigmatization, there is less reason to think that it can do the same for phenotypic devaluation. (shrink)

Although Broad published many books in his lifetime, this volume is unique in presenting some of his most interesting unpublished writings. Divided into five clear sections, the following figures and topics are covered: Autobiography, Hegel and the nature of philosophy, Francis Bacon, Hume's philosophy of the self and belief, F. H. Bradley, The historical development of scientific thought from Pythagoras to Newton, Causation, Change and continuity, Quantitative methods, Poltergeists, Paranormal phenomena. -/- Each section is introduced and placed in context by (...) the editor, Joel Walmsley. The volume also includes an engaging and informative foreword by Simon Blackburn. It will be of great value to those studying and researching the history of twentieth-century philosophy, metaphysics, and the recent history and philosophy of science, as well as anyone interested in Broad's philosophical thought and his place in the history of philosophy. (shrink)

Shortages of new therapeutics to treat coronavirus disease (COVID-19) have forced clinicians, public health officials, and health systems to grapple with difficult questions about how to fairly allocate potentially life-saving treatments when there are not enough for all patients in need (1). Shortages have occurred with remdesivir, tocilizumab, monoclonal antibodies, and the oral antiviral Paxlovid (2) -/- Ensuring equitable allocation is especially important in light of the disproportionate burden experienced during the COVID-19 pandemic by disadvantaged groups, including Black, Hispanic/Latino and (...) Indigenous communities, individuals with certain disabilities, and low-income persons. However, many health systems have resorted to first-come, first-served approaches to allocation, which tend to disadvantage individuals with barriers in access to care (3). There is mounting evidence of racial, ethnic, and socioeconomic disparities in access to medications for COVID-19 (4, 5). -/- One potential method to promote equitable allocation is to use a weighted lottery, which is an allocation strategy that gives all eligible patients a chance to receive the scarce treatment while also allowing the assignment of higher or lower chances according to other ethical considerations (6). We sought to assess the feasibility of implementing a weighted lottery to allocate scarce COVID-19 medications in a large U.S. health system and to determine whether the weighted lottery promotes equitable allocation. (shrink)

Eliminative reasoning is a method that has been employed in many significant episodes in the history of science. It has also been advocated by some philosophers as an important means for justifying well-established scientific theories. Arguments for how eliminative reasoning is able to do so, however, have generally relied on a too narrow conception of evidence, and have therefore tended to lapse into merely heuristic or pragmatic justifications for their conclusions. This paper shows how a broader conception of evidence not (...) only can supply the needed justification but also illuminates the methodological significance of eliminative reasoning in a variety of contexts. (shrink)

In this groundbreaking work, C. D. C. Reeve uses a fundamental problem--the Primacy Dilemma--to explore Aristotle's metaphysics, epistemology, dialectic, philosophy of mind, and theology in a new way. At a time when Aristotle is most often studied piecemeal, Reeve attempts to see him both in detail and as a whole, so that it is from detailed analysis of hundreds of particular passages, drawn from dozens of Aristotelian treatises, and translated in full that his overall picture of Aristotle emerges. Primarily a (...) book for philosophers and advanced students with an interest in the fundamental problems with which Aristotle is grappling, Substantial Knowledge's clear, non-technical and engaging style will appeal to any reader eager to explore Aristotle's difficult but extraordinarily rewarding thought. (shrink)

Bizarre delusions are not specific to schizophrenia and can be found in other psychotic disorders. However, to date, there are no studies investigating socio-demographic and clinical characteristics associated with BizD across the psychosis spectrum. In this study 819 subjects with a diagnosis of SZ, schizoaffective disorder and bipolar I disorder were included. Patients with history of BizD and with no BizD were compared with respect to socidemographic and clinical variables, and predictors of BizD were explored. Patients with BizD were less (...) educated, less likely to be married, had higher Positive and Negative Syndrome Scale negative scores and lower Young Mania Rating Scale scores. Younger age, SZ and SZA diagnoses, higher PANSS positive scores, presence of reference delusions, tactile and olfactory hallucinations were predictors. Our results indicate that BizD are associated with higher illness severity, lower functionality and specific set of symptoms. (shrink)

This book collects texts from three specialists in ancient philosophy which deal with the question of perceptive and intellective knowledge in antiquity. They try to present, in their different analyzes, the complex interrelationship among perception and thought in ancient authors, like Heraclitus, Parmenides, Democritus, Plato and Aristotle. The purpose of the texts is to expose the visible field - the perceptual knowledge domain - interacts with the invisible - the domain of reason and thought. In other words, that among them (...) there is no a radical separation of these two areas, although they are clearly distinct. (shrink)

Philosophical debates on how to account for the progress of science have traditionally divided along the realism-anti-realism axis. Relatively recent developments in epistemology, however, have opened up a new knowledge-understanding axis to the debate. This chapter presents a novel understanding-based account of scientific progress that takes its motivation from problem-solving practices in science. Problem-solving is characterized as a means of measuring degree of understanding, which is argued to be the principal epistemic (or cognitive) aim of science, over and against knowledge. (...) This account is then defended against knowledge reductionism by showing how each plays an important and distinctive role in science. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Reviewed by:The Christian Structure of Politics: On the De Regno of Thomas Aquinas by William McCormickD. C. SchindlerMcCORMICK, William. The Christian Structure of Politics: On the De Regno of Thomas Aquinas. Washington, D.C.: The Catholic University of America Press, 2022. xiii + 272 pp. Cloth, $75.00Challenging general assumptions that, because of its genre as a letter to a king in the speculum principis tradition, Aquinas's De Regno is a (...) minor source for Aquinas's political theory in comparison to the political passages from the Summa and Sentence Commentary, William McCormick, S.J. presents a new interpretation of this somewhat neglected text. Though there exist a few classic articles comparing Aquinas's thought in this letter and elsewhere, and substantial introductions to the De Regno in editions by Eschmann (1949) and Dondaine (1979), The Christian Structure of Politics is the first book-length study of Aquinas's letter to the king of Cyprus. In this respect, the volume makes a very welcome contribution to our understanding of Aquinas's understanding of political order, bringing out a dimension of his thought—its awareness of history and its pedagogical sensitivity—not so apparent in Aquinas's other writings.The book is very much what it presents itself as being, namely, a "close reading" of the text, following the letter's two parts (the second of which [End Page 150] Aquinas left unfinished) paragraph by paragraph, considering various interpretative possibilities and suspending judgment—the words "might" and "perhaps" are no doubt two of the most frequent in the book—until more evidence comes into view, and working up to general principles only at the end. McCormick thus eschews substantial engagement with theoretical issues that would form the backdrop to the discussion (for example, the relation between nature and grace, and between practical and theoretical reason), opting instead to focus on a more immediate engagement with what is presented in the text itself. He also does not make more than passing comments on Aquinas's better-known formulations on political matters from the Summa or Sentences Commentary. On the other hand, the "close reading" does not keep McCormick from discerning a general order in Aquinas's letter, which he divides up thematically according to a proposed schema. His approach shows a sensitivity to the historical context in which Aquinas was writing, even if particular details about Aquinas's addressee and the occasion of composition remain uncertain, but his aim is not simply to produce a historical study. Instead, as the book's title itself already indicates, he investigates the De Regno in order to show that the text offers fundamental principles for a distinctively Christian approach to politics, and thus can shed light even on our contemporary situation.The book is divided into five basic chapters, in addition to a substantial introduction and brief conclusion. The first four chapters follow the order of the De Regno, though the basic lines of division are McCormick's own interpretative proposal. Chapter 1 treats the letter's prooemium and the first two chapters of part one (I.1-2) under the title "The Aristotelian State of Nature," showing that, contrary to ideas found in a certain current of Christian thought, political order is fully natural to man and not simply a practical response to violence. Chapter 2, "The Augustinian Earthly City," treating I.3-6, complements the natural character of politics with the realistic acknowledgment of man's fallen nature. While some commentators have worried that the discussion of tyranny in these and subsequent chapters of the De Regno eclipses the positive account of politics given rather schematically at the start, and so diminishes the interest the text might hold for the political philosopher, McCormick argues that the engagement with the tyrant, and the disorder he generates, represents an essential dimension of Aquinas's political vision. Indeed, one of the principal theses of The Christian Structure of Politics is that Aquinas manages to integrate Aristotelian and Augustinian perspectives in an unusually illuminating way: Christian revelation, which introduces the eschatological horizon and foregrounds the historical narrative of sin and redemption, does not supplant but instead grounds and deepens the integrity of politics and... (shrink)

Several physicists, among them Hawking, Page, Coule, and Carroll, have argued against the probabilistic intuitions underlying fine-tuning arguments in cosmology and instead propose that the canonical measure on the phase space of Friedman-Robertson-Walker space-times should be used to evaluate fine-tuning. They claim that flat space-times in this set are actually typical on this natural measure and that therefore the flatness problem is illusory. I argue that they misinterpret typicality in this phase space and, moreover, that no conclusion can be drawn (...) at all about the flatness problem by using the canonical measure alone. (shrink)

It is commonly observed that behind many of the political and cultural issues that we face today there are impoverished conceptions of freedom, which, according to D. C. Schindler, we have inherited from the classical liberal tradition without a sufficient awareness of its implications. Freedom from Reality presents a critique of the deceptive and ultimately self-subverting character of the modern notion of freedom, retrieving an alternative view through a new interpretation of the ancient tradition. While many have critiqued the inadequacy (...) of identifying freedom with arbitrary choice, this book seeks to penetrate to the metaphysical roots of the modern conception by going back, through an etymological study, to the original sense of freedom. Schindler begins by uncovering a contradiction in John Locke's seminal account of human freedom. Rather than dismissing it as a mere "academic" problem, Schindler takes this contradiction as a key to understanding the strange paradoxes that abound in the contemporary values and institutions founded on the modern notion of liberty: the very mechanisms that intend to protect modern freedom render it empty and ineffectual. In this respect, modern liberty is "diabolical"--a word that means, at its roots, that which "drives apart" and so subverts. This is contrasted with the "symbolical" (a "joining-together"), which, he suggests, most basically characterizes the premodern sense of reality. This book will appeal to students and scholars of political philosophy (especially political theorists), philosophers in the continental or historical traditions, and cultural critics with a philosophical bent. (shrink)

The computer has increasingly become the principal model for the mind, which means our most basic experience of ""reality"" is as mediated through a screen, or stored in a cloud. As a result, we are losing a sense of the concrete and imposing presence of the real, and the fundamental claim it makes on us, a claim that Iris Murdoch once described as the essence of love. In response to this postmodern predicament, the present book aims to draw on the (...) classical philosophical tradition in order to articulate a robust philosophical anthropology, and a new appreciation of the importance of the ""transcendental properties"" of being: beauty, goodness, and truth. The book begins with a reflection on the importance of metaphysics in our contemporary setting, and then presents the human person's relation to the world under the signs of the transcendentals: beauty is the gracious invitation into reality, goodness is the self-gift of freedom in response to this invitation, and truth is the consummation of our relation to the real in knowledge. The book culminates in an argument for why love is ultimately a matter of being, and why metaphysical reason in indispensable in faith. ""Philosopher D. C. Schindler defies the dragon of modernity, whose dominant thought patterns induce a life- and culture-threatening loss of reality and self. He offers life-giving proposals regarding love, being, and the transcendentals to restore us profoundly to the world and to ourselves as humans. Buy the book--you may divest yourself of others. Digest it, and revel in your already-involvement with a responsive reality--an involvement of intimate encounter and communion; a reality that is love, fraught with beauty, goodness, and truth."" --Esther Lightcap Meek, Geneva College ""Love and the Postmodern Predicament is a treasure trove of philosophical riches. Schindler does not merely indicate the need to return to metaphysics to wrestle successfully with what he carefully and accurately describes as our postmodern predicament, but in fact leads us out of that predicament. His profound and original reflections on love, grounded in the transcendental properties of being, are a radical refashioning of traditional metaphysical principles."" --Jonathan J. Sanford, University of Dallas ""In this rewarding little text, Schindler accomplishes something too rare among works of philosophy: he accommodates a wide audience and yet deftly draws the reader into deep metaphysical waters, into a consideration of some of the most profound and perennial philosophical concerns. Throughout, the timeliness of his reflections on love, beauty, God, and the good remains in clear view. This is a highly recommended work by an author of capacious intellect and generous spirit."" --Lee M. Cole, Hillsdale College D. C. Schindler is Associate Professor of Metaphysics and Anthropology at The John Paul II Institute at The Catholic University of America. He is the author of The Perfection of Freedom: Schiller, Schelling, and Hegel between the Ancients and the Moderns (2013). (shrink)

In his much-explored argument for the tripartition of the soul in book IV of the Republic, Socrates makes use of two principles, which I shall call the principle of opposition and the principle of qualification. The aim of the present paper is to explain, in particular, the second of these principles, so as to reveal its role in that argument and in the conception of an appetite and of the appetitive part that is central to the larger argument of the (...) Republic as a whole. Section 1 briefly introduces the principle of opposition, analyzes the principle of qualification, and presents the argument for tripartition. Section 2 uses the analysis of the principle of qualification to interpret a claim Socrates makes about the soul and its relation to the good, which seems at odds with the account of appetites uncovered in Sect. 1. Then, in Sect. 3, the relevance of the principle of qualification to Socratic intellectualism—the view that knowledge is sufficient for virtue—is explored. In Sect. 4, appetites are returned to with the focus now on the varieties of them that Socrates recognizes. In Sect. 5, a view is put forward about the nature of the appetitive part (Appetite), its beliefs, and its ability to be persuaded by the rational part (Reason). In Sect. 6, it is argued that Appetite and Reason are both souls, capable of working in harmony, but also of being opposed, thereby underwriting an important part of the analogy between the polis and the soul on which much of the Republic relies. (shrink)

This paper examines the realist interpretation of Vedānta that Rasvihari Das explicated in two of his celebrated treatises, namely, “The Theory of Ignorance in Advaitism” and “The Falsity of the World.” Rasvihari Das, unlike many of his contemporary thinkers of India, took a contrary position against the uninformed generalization about Indian thought that the philosophical tradition of India was one of an unbroken idealism and spiritualism. Though Rasviahari Das was influenced by his senior peer-thinkers of India like Hiralal Haldar, B. (...) N. Seal, and K. C. Bhattacharyya, Rasvihari Das had his own independent view on and interpretation of Vedānta. The paper argues that in the Vedāntic realism of Rasvihari Das there is no rejection of the world or the individuals. In the first part of the paper, I suggests the possible influence of Indian realism on Rasvihari Das. In the second part, I make an attempt to unearth and examine the interpretation of Rasvihari Das that unravels his Vedāntic realism. The third part is the concluding appraisal of Rasvihari Das who could take Vedānta forward from its religious moorings and place it resolutely on a philosophical candour. (shrink)

Hermann Weyl was one of the most important figures involved in the early elaboration of the general theory of relativity and its fundamentally geometrical spacetime picture of the world. Weyl’s development of “pure infinitesimal geometry” out of relativity theory was the basis of his remarkable attempt at unifying gravitation and electromagnetism. Many interpreters have focused primarily on Weyl’s philosophical influences, especially the influence of Husserl’s transcendental phenomenology, as the motivation for these efforts. In this article, I argue both that these (...) efforts are most naturally understood as an outgrowth of the distinctive mathematical-physical tradition in Göttingen and also that phenomenology has little to no constructive role to play in them. (shrink)

This book provides an exploration of the epistemological, metaphysical, and psychological foundations of the Nicomachean Ethics. Rejecting current orthodoxy, this book argues that scientific-knowledge (episteme) is possible in ethics, that dialectic and understanding (nous) play essentially the same role in ethics as in an Aristotelian science, and that the distinctive role of practical wisdom (phronēsis) is to use the knowledge of universals provided by science, dialectic, and understanding so as best to promote happiness (eudaimonia) in particular circumstances and to ensure (...) a happy life. Turning to happiness itself, the book develops a new account of Aristotle's views on ends and functions, exposing their twofold nature. It argues that the activation of theoretical wisdom is primary happiness, and that the activation of practical wisdom — when it is for the sake of primary happiness — is happiness of a second kind. He concludes with an account of the virtues of character, external goods, and friends, and their place in the happy life. (shrink)

This book shows you what it is like to think along with Aristotle and helps you to see the universe and our place in it as he thought they had to be seen to be scientifically intelligible. As a portrait is composed of colors and shapes that collectively represent someone, so Aristotles works are composed of arguments that collectively represent the causal structure of the universe, from the stones, plants, and animals around us to the starry heavens above and the (...) god beyond them. The aim of this brief immersion is to guide you through those arguments in a way that lets you understand for yourself why they proceed as they do and end where they do."--Publisher. (shrink)

Cognitive neuroenhancement involves the use of medical interventions to improve normal cognitive functioning such as memory, focus, concentration, or willpower. In this paper I give a Kantian argument defending the use of CNE in science, scholarly research, and creative fields. Kant’s universal law formulation of the categorical imperative shows why enhancement is morally wrong in the familiar contexts of sports or competitive games. This argument, however, does not apply to the use of CNE in higher education, scholarly or scientific research, (...) or creative endeavors such as visual art, fiction or poetry, or musical composition. This is because performance in these areas is embedded within practices that differ in morally significant ways from competitive practices. This important difference provides good reason to think that there is nothing morally wrong with the use of CNE in these areas. My approach is not simply to assume a full-fledged Kantian ethical theory and apply it straight away to the enhancement issue but to establish a reflective equilibrium between our moral intuitions, moral principles that support those intuitions, and the nature of the practices involved. (shrink)

O artigo oferece uma breve exposição da biografia e do contexto histórico do filósofo neoplatônico Damáscio (c. 458 - c. 538) para, na sequência, apresentar a tradução de um dos seus poemas líricos do período final de sua vida. O procedimento adotado justifica-se pelo caráter lutuoso e decididamente pessoal dos versos, nos quais Damáscio lamenta consigo próprio as perdas sofridas no decorrer de sua longa e fascinante vida. Como veremos, tais perdas estão, em verdade, diretamente ligadas ao colapso do mundo (...) antigo e ao derradeiro golpe proferido por Justiniano contra a filosofia helênica pagã. (shrink)