Benefit sharing in health research has been the focus of international debates for many years, particularly in developing countries. Whilst increasing attention is being given to frameworks that can guide researchers to determine levels of benefits to participants, there is little empirical research from developing countries on the practical application of these frameworks, including in situations of extreme poverty and vulnerability. In addition, the voices of those who often negotiate and face issues related to benefits in practice - frontline researchers (...) and fieldworkers - are rarely included in these debates. Against this background, this paper reports on experiences of negotiating research participation and benefits as described by fieldworkers, research participants and researchers in two community based studies. (shrink)

Community engagement is increasingly emphasized in biomedical research, as a right in itself, and to strengthen ethical practice. We draw on interviews and observations to consider the practical and ethical implications of involving Community Health Workers (CHWs) as part of a community engagement strategy for a vaccine trial on the Kenyan Coast. CHWs were initially engaged as an important network to be informed about the trial. However over time, and in response to community advice, they became involved in trial information (...) sharing and identifying potential participants; thereby taking on roles that overlapped with those of employed fieldworkers (FWs). While CHWs involvement was generally perceived as positive and appreciated, there were challenges in their relations with FWs and other community members, partly related to levels and forms of remuneration. Specifically, payment of CHWs was not as high as for FWs and was based on ‘performance’. This extrinsic motivation had the potential to crowd out CHWs intrinsic motivation to perform their pre-existing community roles. CHWs remuneration potentially also contributed to CHWs distorting trial information to encourage community members to participate; and to researchers encouraging CHWs to utilize their social connections and status to increase the numbers of people who attended information giving sessions. Individual consent processes were protected in this trial through final information sharing and consent being conducted by trained clinical staff who were not embedded in study communities. However, our experiences suggest that roles and remuneration of all front line staff and volunteers involved in trials need careful consideration from the outset, and monitoring and discussion over time. (shrink)

Internationally, calls for feedback of findings to be made an ‘ethical imperative’ or mandatory have been met with both strong support and opposition. Challenges include differences in issues by type of study and context, disentangling between aggregate and individual study results, and inadequate empirical evidence on which to draw. In this paper we present data from observations and interviews with key stakeholders involved in feeding back aggregate study findings for two Phase II malaria vaccine trials among children under the age (...) of 5 years old on the Kenyan Coast. In our setting, feeding back of aggregate findings was an appreciated set of activities. The inclusion of individual results was important from the point of view of both participants and researchers, to reassure participants of trial safety, and to ensure that positive results were not over-interpreted and that individual level issues around blinding and control were clarified. Feedback sessions also offered an opportunity to re-evaluate and re-negotiate trial relationships and benefits, with potentially important implications for perceptions of and involvement in follow-up work for the trials and in future research. We found that feedback of findings is a complex but key step in a continuing set of social interactions between community members and research staff (particularly field staff who work at the interface with communities), and among community members themselves; a step which needs careful planning from the outset. We agree with others that individual and aggregate results need to be considered separately, and that for individual results, both the nature and value of the information, and the context, including social relationships, need to be taken into account. (shrink)

Initiated by Robert Wesson, _Evolution and Human Values_ is a collection of newly written essays designed to bring interdisciplinary insight to that area of thought where human evolution intersects with human values. The disciplines brought to bear on the subject are diverse - philosophy, psychiatry, behavioral science, biology, anthropology, psychology, biochemistry, and sociology. Yet, as organized by co-editor Patricia A. Williams, the volume falls coherently into three related sections. Entitled Evolutionary Ethics, the first section brings contemporary research to an (...) area first explored by Herbert Spencer. Evolutionary ethics looks to the theory of evolution by natural selection to find values for human living. The second section, Evolved Ethics, discusses the evolution of language and religion and their impact on moral thought and feeling. Evolved ethics was partly Charles Darwin's subject in _The Descent of Man._ The last section bears the title Scientific Ethics. A nascent field, scientific ethics asks about the evolution of human nature and the implications of that nature for ethical theory and social policy. Together, the essays collected here provide important contemporary insights into what it is - and what it may be - to be human. (shrink)

In this paper, I compare the use of the thermodynamic limit in the theory of phase transitions with the infinite-time limit in the explanation of equilibrium statistical mechanics. In the case of phase transitions, I will argue that the thermodynamic limit can be justified pragmatically since the limit behavior also arises before we get to the limit and for values of N that are physically significant. However, I will contend that the justification of the infinite-time limit is less straightforward. In (...) fact, I will point out that even in cases where one can recover the limit behavior for finite t, i.e. before we get to the limit, one cannot recover this behavior for realistic time scales. I will claim that this leads us to reconsider the role that the rate of convergence plays in the justification of infinite limits and calls for a revision of the so-called Butterfield’s principle. (shrink)

As we look to the future in a world with porous borders and boundaries transgressed by technologies, an inevitable question is:Can there be a single, global bioethics? Intimately intertwined with this question is a second one: How might a global bioethics account for profound - and constantly transforming - sources of cultural difference? Can a uniform, global bioethics be relevant cross-culturally? These are not simple questions, rather, a multi-dimensional answer is required. It is important to distinguish between two meanings of (...) bioethics: the academic discipline of bioethics as opposed to bioethics as a set of practices governing clinical care and scientific research. There is growing evidence to support the notion of a shared global understanding of bioethics as a field of inquiry focused on the moral dimensions of science and biomedicine. (shrink)

Psychopaths are agents who lack the normal capacity to feel moral emotions (e.g. guilt based on empathy with the victims of their actions). Evidence for attributing psychopathy at least in some cases to genetic or early childhood causes suggests that psychopaths lack free will. However, the paper defends a sense in which psychopaths still may be construed as responsible for their actions, even if their degree of responsibility is less than that of normal agents. Responsibility is understood in Strawsonian terms, (...) as a question of our appropriate reactive attitudes toward an agent for what she does, and as distinct from the question of the agent's own motivating attitudes, which lead him to do what he does. The latter is the question more directly relevant to free will, though moral motivation normally depends on the capacity in early childhood to pick up motivating attitudes from others' reactive attitudes. Reactive attitudes based on hatred rather than anger (e.g. disgust or contempt) count as alternative forms of blame that may be appropriately directed toward agents manifesting bad qualities of will, even as a matter of motivational impairment. So psychopaths may still be said to deserve blame, even if they are incapable of modifying their behavior in response to blame. (shrink)

In this chapter, I defend a pluralistic approach to intertheoretic reduction, in which reduction is not understood in terms of a single philosophical “generalized model”, but rather as a family of models that can help achieve certain epistemic and ontological goals. I will argue then that the reductive model (or combination of models) that best suits to a particular case study depends on the specific goals that motivate the reduction in the intended case study.

Scientists investigating the thermal properties of black holes rely heavily on theoretical and non-empirical tools, such as mathematical derivations, analogue experiments and thought experiments. Although the use of mathematical derivations and analogue experiments in the context of black hole physics has recently received a great deal of attention among philosophers of science, the use of thought experiments (TEs) in that context has been almost completely neglected. In this paper, we will start filling this gap by systematically analyzing the epistemic role (...) of the two TEs that gave birth to black hole thermodynamics, namely Wheeler’s demon and Geroch’s engine. We will argue that the two main epistemic functions of these TEs are to reveal and resolve inconsistencies, in line with El Skaf’s (Probing theoretical statements with thought experiments. Synthese 199:6119–6147, 2021) approach to TEs. We will, then, go beyond El Skaf’s approach by stressing an important difference between the strategies employed to assess the reliability of each epistemic function. (shrink)

Despite Kemp Smith's claims to the contrary, I show that there is good reason to believe that Kant was aware of Hume's attack on personal identity. My interpretive claim is that we can make sense of many of Kant's puzzling remarks in the subjective deduction by assuming that he was trying to reply to Hume's challenge. My substantive claim is that Kant succeeds in defending a notion of the self as a continuing sequence of informationally interdependent states.

In Quod animi mores, Galen says both that there is an identity between the capacities of the soul and the mixtures of the body, and that the soul’s capacities ‘follow upon’ the bodily mixtures. The seeming tension in this text can be resolved by noting that the soul’s capacities are constituted by, and hence are nothing over and above, bodily mixtures, but bodily mixtures explain the soul’s capacities and not the other way around. Galen’s proposal represents a distinctive position in (...) the Ancient debate on the relationship between soul and body. (shrink)

In Nicomachean Ethics 7.7 (= Eudemian Ethics 6.7), Aristotle distinguishes softness (malakia) from lack of self-control (akrasia) and endurance (karteria) from self-control (enkrateia). This paper argues that unqualified softness consists of a disposition to give up acting to avoid the painful toil (ponos) required to execute practical resolutions, and (coincidentally) to enjoy the pleasures of rest and relaxation. The enduring person, in contrast, persists in her commitments despite the painful effort required to enact them. Along the way, I argue that (...) this interpretation qualifies our understanding of the pleasures and pains with which temperance and intemperance are concerned. (shrink)

: The author seeks an explanation for Merleau-Ponty's expression "the body understands", to which a real value is applied: the objects of the world have a signification that the body grasps by way of perception. The analysis focuses on Merleau-Ponty's Phenomenology of perception and on notes from two of his courses, Le monde sensible et le monde de l'expression and La nature. In these works, there is a constant allusion to the I can as an underlying and grounding mode with (...) regard to the I think. The French philosopher thus grants a central role to movement that demonstrates the interweaving of the body with the world. Resumo: O autor busca uma explicação para a expressão "o corpo conhece", de Merleau-Ponty, à qual atribui um valor real: os objetos do mundo têm uma significação que o corpo apreende por meio da percepção. A análise se concentra na Fenomenologia da percepção e nas notas de dois cursos: O mundo sensível e o mundo da expressão e A natureza. Há uma constante alusão ao eu posso como um modo subjacente e fundamental em relação ao eu penso. Daí, o filósofo francês conferir um papel central ao movimento que demonstra o entrelaçamento do corpo com o mundo. (shrink)

The highest principle of Kant’s theoretical philosophy is that all cognition must “be combined in one single self-consciousness”. Elsewhere I have tried to explain why he believed that all cognition must belong to a single self ; here I try to clarify the other half of the doctrine. What led him to the claim that all cognition involved self-consciousness? This question is pressing, because the thesis strikes many as obviously false.

Most people believe that extraterrestrial beings or porpoises or computers could someday be recognized as persons. Given the significant constitutional differences between these entities and ourselves, the general assumption appears to be that ‘person’ is not a natural kind term. David Wiggins offers an illuminating challenge to this popular dogma in ‘Locke, Butler and the Stream of Consciousness: and Men as a Natural Kind’. Wiggins does not claim that ‘person’ actually is a natural kind term; but he argues hard for (...) the advantages of regarding it as something like a natural kind classification. The problem is that, whatever its merits, there are obvious and fatal objections to the view that person is a natural kind. My aim is to present a modification of the natural kind thesis which avoids these objections and retains the attractions of the basic position. (shrink)

One of the most common threads in the Caribbean tapestry races which have populated the region over the last five centuries largely through forced or voluntary migration, is that there have emerged mixtures of the different racial groups. A large proportion of Caribbean women and men are referred to euphemistically as ‘mixed race’. The terms used to describe people of mixed race vary by territory and have been incrementally added to or changed over time. The original nomenclatures such as sambo, (...) musteephino, mulatto, creole, etc. have been replaced at present to include terms like brown skin, mulatto, clear skin, light skin, red-nigger, dougla and browning. The title of the article comes from a contemporary dancehall song in Jamaica in which the black singer, Buju Banton, unwittingly echoes an unspoken yet shared notion of female desirability in the Caribbean: a preference for ‘brown’ as opposed to black women or unmixed women. In the ongoing constructions of femininity in the region, class and skin colour have intersected with race to produce hierarchies and stereotypes of femininity based on racial mixing. Drawing on some of the historical data available, particularly that of the pioneering research in this area produced by Lucille Mathurin in 1974, this article interrogates some aspects of miscegenation in the Jamaican past, to configure these with gender, race and class relations in the present. The article does not attempt to arrive at conclusive findings but to contribute to the ongoing process in the region, and elsewhere, of differentiating the category ‘woman’ in historiography and sociology. (shrink)

What value does genomics hold for industry? Ten years after the White House Press conference where the human genome sequence was first presented, we ask in which ways and to what extent the developments in genomics have been integrated into industry. This enables us to assess whether this integration has been as successful as expected, but also which unexpected developments in genomics advances have triggered additional benefits for industry. Genomics has contributed to the beginning of a global transition to a (...) bio-based economy, but there have been and there still are hurdles to be cleared. The hurdles are not merely of a technological nature, since the objectives are a complex between economic progress, environmental and global climate concerns, and energy security. Therefore, they are at the same time technological, societal and environmental in nature. These categorisations fall short of articulating the many issues that arise, such as economic development (for emerging economies), public opinion formation and scientific and technological progress. We argue that to make this transition happen, industrialists, policy makers and the wider public have to be prepared to be more actively involved in the debate, weighing the pros and cons and taking responsibility in creating the desired sustainable world.This paper will examine the advances of genomics in the industrial context, the role of these advances in current attempts to find sustainable solutions to a variety of problems, the enthusiasm with which they have been picked up, the implications for industrial innovation and the accompanying discussion about possible consequential social and ethical issues. It will also sketch out the nature of this ongoing establishment of a bio-based economy, the parties that are currently at the negotiation table, and whether the current situation has an impact on the way societal debates emerge. (shrink)

Although both Kant and Wittgenstein made claims about the “unknowability” of cognitive subjects, the current practice of assimilating their positions is mistaken. I argue that Allison’s attempt to understand the Kantian self through the early Wittgenstein and McDowell’s linking of Kant and the later Wittgenstein distort rather than illuminate. Against McDowell, I argue further that the Critique’s analysis of the necessary conditions for cognition produces an account of the sources of epistemic nonnativity that is importantly different from McDowell’s own account (...) in terms of a ‘second nature’ created through ‘Bildung’. Finally, I argue that Kant’s epistemic analyses also lead to a model of the cognitive self that answers two contemporary questions: why should we refer to selves at all? in what dies the unity of a subject of thought consist? (shrink)

Reason and emotion are often cast as opposites. Yet emotion comes in a wide array of manifestations and has a variety of relations with its supposed opposite. Understanding emotion better is key to grasping how jurisprudence casts the relation between psychology and judicial decision making. Jurisprudents disagree on whether and when (lack of) emotion is a problem for decision makers in the justice system. The aim of this paper is to shed light on unarticulated assumptions in mainstream legal theory concerning (...) this disagreement. The paper plots the different positions jurisprudents hold concerning the role of emotion in judicial decision making, regardless of where they stand on matters such the nature of law. The paper substantiates the claim that legal theorists often take an irrationalist approach to emotion but occasionally develop an alternative account that is closer to a cognitivist approach, the prime example of which is the claim that equity requires practical reasoning. Emotions are then cast as skills to be appreciated. The paper concludes that jurisprudence adopts a simplistic view of emotion. The study of the role of emotion has been hampered by the tendency to view emotions reductively. My classificatory effort warrants the conclusion that lack of emotion – understood as a skill in cognitivist terms – constitutes a problem for justice. (shrink)

This essay rearticulates historical and contemporary security discourse as a politics of desire bound to a masculinist and racialized notion of Selfhood. The Persian Gulf War and the Canada/Spain Turbot War are presented as case studies which typify how the securing of desire through warfare proceeds from an idea of the desirous rival a Other. The essay counters Guardian and Lananian narratives of a desire which emanates from a sense of lack, and leads to violence, with Levinas's understanding of desire (...) as central to, rather than disruptive of, an ethical relation with alterity. (shrink)

Trata-se de uma resenha da tradução de Celi Hirata das Questões sobre a Liberdade, a Necessidade e o Acaso de Thomas Hobbes.

The language of evolutionary biology and psychology is built on concepts applicable in the first instance to individual strategic rationality but extended to the level of genetic explanation. Current discussions of mental disorders as evolutionary adaptations would apply that extended language back to the individual level, with potentially problematic moral/political implications as well as possibilities of confusion. This paper focuses on one particularly problematic area: the explanation of women's greater tendency to depression. The suggestion that there are "good evolutionary reasons" (...) for depression makes sense, and might be helpful to note in therapy, as implying that the tendency is not a defect. However, evolutionary adaptiveness should not be confused with individual or psychological adaptiveness. Besides making reference to an earlier environment, it presupposes a strategic standpoint that may not accord with the legitimate interests of the individual, as this example makes vivid. (shrink)

El objetivo del trabajo es plantear una revisión de los clásicos de la filosofía para ampliar nuestro conocimiento histórico y, a la vez, abrir la puerta a nuevas posibles conceptualizaciones de lo político. Concretamente, defendemos que puede haber relevantes pensadoras entre las mujeres religiosas del Renacimiento (y probablemente antes), cuyos escritos son difíciles de analizar desde la perspectiva empleada para estudiar los textos prototípicos del género discursivo. Para solventar esta dificultad, partimos de dos premisas: a) la configuración de los universos (...) discursivos en que se les permite tomar parte no tiene por qué coincidir con la de los discursos prototípicamente masculinos; y b) no se puede comprender el buen gobierno del convento, entendido como una particular civitas (filosofía política), sin la experiencia religiosa femenina como medio para legitimar un poder que no les es reconocido por medios humanos (mística política). A modo de ejemplo, analizamos desde esta distinción entre filosofía política y mística política dos tratados de la carmelita descalza María de san José Salazar, _Consejos que da una priora_ (1590) y _Maestra de novicias_ (1602), en los que se proponen recomendaciones para el virtuoso gobierno conventual femenino basadas en una incuestionable experiencia de gestión. (shrink)

O presente estudo argumenta que, para Hobbes, a retórica constituiu-se como um importante aparato linguístico e conceitual disponível em seu tempo, sobretudo para a descrição dos fenômenos físicos na ciência experimental nascente no contexto do século XVII inglês. Considerando que os parâmetros epistêmicos na descrição desta ciência estavam por se desenvolver, Hobbes buscou soluções nas doutrinas das artes do bem falar, a começar em sua antropologia. A noção de conato em Hobbes indica o peso da tradição retórica clássica em sua (...) filosofia, com destaque para Aristóteles, os estoicos e Quintiliano. Veremos como a retórica, articulada à física e à ética, constituiu um relevante paradigma de expressão e de investigação de Thomas Hobbes sobre o conato e vai além do ornamento do texto em seu estudo sobre os corpos. (shrink)

This essay engages in a debate with Nancy Fraser and Dorothy Leland concerning the contribution of Lacanian-inspired psychoanalytic feminism to feminist theory and practice. Teresa Brennan's analysis of the impasse in psychoanalysis and feminism and Judith Butler's proposal for a radically democratic feminism are employed in examining the issues at stake. I argue, with Brennan, that the impasse confronting psychoanalysis and feminism is the result of different conceptions of the relationship between the psychical and the social. I suggest Lacanian-inspired feminist (...) conceptions are useful and deserve our consideration. (shrink)

We prove that the (non-intuitionistic) law of the double negation shift has a bounded functional interpretation with bar recursive functionals of finite type. As an application. we show that full numerical comprehension is compatible with the uniformities introduced by the characteristic principles of the bounded functional interpretation for the classical case.

Ours is a time of dramatic and confusing transformations in everyday life, many of them originating in the social enfranchisement of women that has occurred over the past twenty-five years. Sociologist Arlie Hochschild demonstrates a widespread phenomenon of work-family imbalance in our society, experienced by people in terms of a time bind, and a devaluation of familial relationships. As large numbers of women have moved into the workplace, familial relations of all sorts have been colonized by what Virginia Held critically (...) refers to as the contractual paradigm. Even the mother/child relationship, representing for Held an alternative feminist paradigm of selfhood and agency, has been in large part "outsourced." I believe that an Arendtian conception of speech and action might enable us to assert anew the grounds for familial relations. If we require a new site upon which to address our human plurality and natality, the postpatriarchal family may provide that new site upon which individuals can freely act to recreate the fabric of human relationships. It would seem to be our moral and political responsibility as social philosophers today to speculatively contribute to the difficult yet imperative task of reconfiguring the family. In this paper, I attempt to articulate the basic assumptions from which such a reconfiguration must begin. (shrink)

Biomass such as crops and agricultural waste is increasingly used as the primary resource for products like bioplastics and biofuels. Incorporating the needs, knowledge, skills and values of biomass producers in the design of global value chains – the steps involved in creating any finished product from design to delivery – can contribute to sustainability, reliability and fairness. However, how to involve biomass producers, especially if they are resource poor, remains a challenge. To make sure that inclusion in global biobased (...) value chains is both fair and effective, the capabilities of relevant actors need to be taken into account, especially of those producing biomass. Access to resources determines to what extent a specific actor can participate in a global value chain. Therefore, differences in capabilities should be a central consideration when new (biobased) value chains are designed. Using the capability approach as an ethical framework to realize inclusion, we discern three complementary strategies for setting up inclusive value chains. Firstly, designing for local conversion factors second, providing adaptive design for new capabilities, and third, investing in local conversion factors. Applying these strategies can lead to context-sensitive design of biorefineries that allow for true inclusion of local stakeholders. We support these claims with reference to case-studies of sugarcane production in Jamaica, modified tobacco in South Africa and the non-edible parts of corn (stover) in the US. (shrink)