This chapter describes the potential far‐reaching consequences of contemplative higher education for the fields of science and medicine.

People are minded creatures; we have thoughts, feelings and emotions. More intriguingly, we grasp our own mental states, and conduct the business of ascribing them to ourselves and others without instruction in formal psychology. How do we do this? And what are the dimensions of our grasp of the mental realm? In this book, Alvin I. Goldman explores these questions with the tools of philosophy, developmental psychology, social psychology and cognitive neuroscience. He refines an approach called simulation theory, which (...) starts from the familiar idea that we understand others by putting ourselves in their mental shoes. Can this intuitive idea be rendered precise in a philosophically respectable manner, without allowing simulation to collapse into theorizing? Given a suitable definition, do empirical results support the notion that minds literally create surrogates of other peoples mental states in the process of mindreading? Goldman amasses a surprising array of evidence from psychology and neuroscience that supports this hypothesis. (shrink)

The question of trusting introspective reports is a question about evidential warrant or justification. It is therefore a question of epistemology, and it behoves us to approach it within the framework of epistemology, which addresses evidential warrant across a broad spectrum of topics and sources. This paper examines the scientific status of introspective reports from the vantage point of general epistemological theorizing.

Heterogeneity within MDD has hampered identification of biological markers (e.g., intermediate phenotypes, IPs) that might increase risk for the disorder or reflect closer links to the genes underlying the disease process. The newer characterizations of dimensions of MDD within Research Domain Criteria (RDoC) domains may align well with the goal of defining IPs. We compare a sample of 25 individuals with MDD compared to 29 age and education matched controls in multimodal assessment. The multimodal RDoC assessment included the primary IP (...) biomarker, positron emission tomography (PET) with a selective radiotracer for 5-HT1A ([11C]WAY-100635), as well as event-related functional MRI with a Go/No-go task targeting the Cognitive Control network, neuropsychological assessment of affective perception, negative memory bias and Cognitive Control domains. There was also an exploratory genetic analysis with the serotonin transporter (5-HTTLPR) and monamine oxidase A (MAO-A) genes. In regression analyses, lower 5-HT1A binding potential (BP) in the MDD group was related to diminished engagement of the Cognitive Control network, slowed resolution of interfering cognitive stimuli, one element of Cognitive Control. In contrast, higher/normative levels of 5-HT1A BP in MDD (only) was related to a substantial memory bias toward negative information, but intact resolution of interfering cognitive stimuli and greater engagement of Cognitive Control circuitry. The serotonin transporter risk allele was associated with lower 1a BP and the corresponding imaging and cognitive IPs in MDD. Lowered 5HT 1a BP was present in half of the MDD group relative to the control group. Lowered 5HT 1a BP may represent a subtype including decreased engagement of Cognitive Control network and impaired resolution of interfering cognitive stimuli. Future investigations might link lowered 1a BP to neurobiological pathways and markers, as well as probing subtype-specific treatment targets. (shrink)

Consciousness researchers standardly rely on their subjects’ verbal reports to ascertain which conscious states they are in. What justifies this reliance on verbal reports? Does it comport with the third-person approach characteristic of science, or does it ultimately appeal to first-person knowledge of consciousness? If first-person knowledge is required, does this pass scientific muster? Several attempts to rationalize the reliance on verbal reports are considered, beginning with attempts to define consciousness via the higher-order thought approach and functionalism. These approaches are (...) either problematic in their own right, or ultimately based on a first-person access to consciousness. A third approach assumes that scientists can trust verbal reports because subjects reliably monitor or ‘introspect’ their conscious states. This raises the question of whether the reliability of introspection can be validated by independent criteria. Merikle's attempts to validate this reliability are shown to involve some unavoidable circularity. It is conjectured that scientists’ reliance on their subjects’ verbal reports tacitly appeals to their own introspective reliability, which is not independently validatable. Some epistemologists might conclude that this renders scientists’ conclusions about conscious states unjustified, but I argue that this does not contravene the constraints of a proper epistemology. (shrink)

Trying to introduce post-graduate management students to the world of philosophy is indeed no easy task. Not only is there a shortage of formal schooling in philosophy amongst business school or business management departmental academic staff, but there is resistance from many sides. Fellow academics question the necessity of such ‘wishy-washy’ issues for business and management students and institutional challenges make it difficult to create a syllabus that falls within the expertise area of another academic department. This paper tracks the (...) development of a postgraduate module introducing students to philosophy and philosophical thinking, but this is not done under the auspices of a Philosophy department. Rather, it is the initiative of a Business Management department. The paper tracks the whole journey of how the module History and Philosophy of Management came to being under the auspices of the Department of Business Management at UJ and presents an argument for an increased focus on and sensitivity toward philosophy and the bearing it has on management research and practice. (shrink)

The process by which the genetically identical cell lineages of a multicellular organism acquire the propensity to express distinct arrays of gene products is among the most significant and fascinating questions in modern biology. Not surprisingly, this complex process requires control at several levels, each level providing a condition that is necessary but not sufficient for transcription to occur. Evidence suggests that one level of control concerns a region of DNA much larger than the transcription unit itself – the chromatin (...) domain. This domain must be in a specific chromatin conformation in order to permit transcription; other control mechanisms may be required to bring about overt transcription. A hypothesis concerning the nature of chromatin domains and the relationship between early replication and transcription potential is presented. (shrink)

Education is on the cusp of a configurational shift, or, as some may argue, in the midst of it. In the last twenty years the direct influence of corporations and their interest in leading educational agencies has substantially increased with no signs of stopping.1 The corporation has become a leader for systemic change in educational practice.2 This systematic change's emphasis on the mighty dollar brings about many different obstacles for educators and educational theorists to consider, one of these being the (...) way education's monetization affects both learners' and educators' motivation. Where does this shift to the focus of funds find such motivations? Looking through the lenses of both John Dewey and... (shrink)

Alvin Goldman examines public and private methods or "pathways" to knowledge, arguing for the epistemic legitimacy of private and introspective methods of gaining knowledge, yet acknowledging the equal importance of social and public mechanisms in the quest for truth.

A lawyer explains the difference between law and ethics--what you can do versus what you should do--and how leaders can create more ethical, satisfying, and profitable workplaces.

Genuine rules cannot capture our intuitive moral judgments because, if usable, they mention only a limited number of factors as relevant to decisions. But morally relevant factors are both numerous and unpredictable in the ways they interact to change priorities among them. Particularists have pointed this out, but their account of moral judgment is also inadequate, leaving no room for genuine reasoning or argument. Reasons must be general even if not universal. Particularists can insist that our judgments be reflective, unbiased, (...) informed, and sensitive, requiring a background of experiences that expand sympathy and empathy for others. But beyond this, our judgments must be coherent. This requirement provides a way to reason to the correct answer to a controversial issue—the answer most coherent with or body of settled judgments. Rawls' account of coherence in terms of reflective equilibrium, where we adjust particular judgments to match rules and adjust rules to match judgments, is rejected since rules have no independent force. Instead, the central requirement is that we not judge cases differently without being able to cite a morally relevant difference between them. Such differences must make a difference else-where as well, although they need not do so universally. Factors cannot be relevant in only one context because they reflect values that must recur to be maintained. The method of moral reasoning based on this requirement is specified as follows: first, the specification of competing values or interests in the problematic case; second, the location of paradigm cases in which these competing values are prioritized, making sure that these settled judgments are reflective, informed, and sensitive; third, the search for relevant differences between the settled and problematic cases or the location of alternative, more closely analogous paradigms. The paper ends with an illustration of the method applied to the issue of doctor assisted suicide. (shrink)

A new class of visuomotor neuron has been recently discovered in the monkey’s premotor cortex: mirror neurons. These neurons respond both when a particular action is performed by the recorded monkey and when the same action, performed by another individual, is observed. Mirror neurons appear to form a cortical system matching observation and execution of goal-related motor actions. Experimental evidence suggests that a similar matching system also exists in humans. What might be the functional role of this matching system? One (...) possible function is to enable an organism to detect certain mental states of observed conspecifics. This function might be part of, or a precursor to, a more general mind-reading ability. Two different accounts of mind-reading have been suggested. According to “theory theory‘, mental states are represented as inferred posits of a naive theory. According to “simulation theory‘, other people’s mental states are represented by adopting their perspective: by tracking or matching their states with resonant states of one’s own. The activity of mirror neurons, and the fact that observers undergo motor facilitation in the same muscular groups as those utilized by target agents, are findings that accord well with simulation theory but would not be predicted by theory theory. (shrink)