Antimicrobial resistance (AMR) poses an increasing threat to patient care and population health and there is a growing need for novel therapies to tackle AMR. Bacteriophage (phage) therapy is a re-emerging antimicrobial strategy with the potential to transform how bacterial infections are treated in patients and populations. Currently, in the UK, phages can be used as unlicensed medicinal products on a ‘named-patient’ basis. We make an ethical case for why it is crucially important for the UK to invest in Good (...) Manufacturing Practice (GMP) for both ongoing unlicensed and future licensed phage therapy. Access to phages produced to GMP (GMP phages) will ensure effective patient care and better outcomes as well as health systems benefits. The UK also has the potential to become a global leader in the timely and cost-efficient manufacturing and supply of a therapy that meets internationally recognised standards. (shrink)

Although Sibawayh dealt with it in a scattered manner under different headings there have been different views on na't (adjective), which is gene-rally included in the tawabi group in Arabic syntax, and there have been debates around these views. Na't, which is categorized as a proper adjective and qualifies the meaning of man'ut (mawsuf), has different characteristics from the sentence elements that indicate the subject. Nahiv scholars have mostly divided na't into two parts: real and causal na't, and they have (...) formulated certain rules for these two parts in accordance with the structure of the Arabic language. Since na't and man'ut are accepted as nouns, the i'rab of na't is subject to men'ut. However, some examples in the Qur'an and some expressions used by the Arabs caused objections to the i'rab of na't being the same as men'ut. It is observed that these objected examples are the cases where men'ut is known and the exceptional cases of madih, zam and jarri jivar. It is also obligatory for the na't to conform to the man'ut in terms of ma'rifiyyah, nekiriyyah, custom and gender. While Sibawayh (d. 180/796) considered it qabh (ugly) for non-propositional words to be na't, scholars such as Ibn Hisham (d. 218/833), Ibn al-Ḥajib (d. 646/1249), and Abd ar-Rahman Jami (d. 898/1492) accepted that na't could be either propositional or non-propositional and cited many examples of na't in the case of non-propositional words. Scholars such as Ibn Jinni (d. 392/1002) and Ibn al-Hajib gave an explanation of the causative na't without naming it, scholars such as Ebu’l-Bekā al-Ukbari (d. 616/1219) analyzed the subject under the title of causative adjective or causative na't, and Halid b. Abdullah al-Azhari discussed it under the title of al-wasf al-majazi. The subject of our study is to examine the handling of na't, which is one of the sentence elements in the Arabic language, in the works written on the field, its parts, the dimension that affects the meaning and the controversial aspects. The aim of the research is to examine the rules that Sibawayh deals with in his al-Kitâb on na'ta and the objections of later Arab linguists to these rules, and to contribute to the field by revealing different views on the subject. (shrink)

The ' argument from queerness', made famous by J. L. Mackie, remains one of the most influential arguments in metaethics. However, many philosophers focus on just one or two of its strands, while others assume a particular but by no means universal reading of it. This essay attempts to disentangle and evaluate all strands of the argument. Surprisingly, when this is done, not much is left as a distinct argument from queerness. Much of the argument collapses (...) into other types of argument, and what is left, though intuitively appealing, is not viable as philosophical argument. (shrink)

"-- M. J. Silverthorne,The Humanities Association Review Leo Strauss (1899-1973) was the Robert Maynard Hutchins Distinguished Service Professor Emeritus of ...

Don Marquis is well known for his future like ours theory, according to which the killing beings like us is seriously morally wrong because it deprives us of a future we can value. According to Marquis, human fetuses possess a future they can come to value, and thus according to FLO have a right to life. Recently Mark Brown has argued that even if FLO shows fetuses have a right to life, it fails to show that fetuses have a right (...) to use their mother's body, evoking Judith Jarvis Thomson's famous violinist case. In the wake of Brown's conclusion, Marquis presents a new argument—the parenthood argument —which he believes shows that abortion is seriously morally wrong. Here I argue that the PA fails to show abortion is seriously morally wrong for the same reasons FLO fails to show abortion is seriously morally wrong. (shrink)

Singer and Dawson point out that two arguments against abortion, that the embryo is entitled to protection because from fertilization it is (1) a human being or (2) a potential human being, are also used by opponents of embryo experimentation. They focus on the second argument, evaluating the notion of potentiality as it applies to gametes, to the unimplanted embryo, to the implanted developing embryo, and to the embryo created by in vitro fertilization (IVF). They argue that there is (...) a crucial distinction between natural reproduction, in which all that is needed for the embryo to have a prospect of reaching its potential is for those involved to refrain from stopping it, and IVF, in which the embryo cannot develop into a person without a deliberate human act. Reproductive techniques necessitate our rethinking of established views about potentiality, and how it should be applied to the embryo in a laboratory. (KIE abstract). (shrink)

In three places Spinoza presents an argument from (a) determinism and (b) God’s “eternity” to (c) “actualism”, i.e., the doctrine that this is (in some sense) the only possible world. That he does so shows that he distinguishes (a) from (c), which he has been thought to conflate. On one reading of ‘eternal’, he is claiming that an infinite past entails no other world was a “real” possibility. As might be expected, the argument is a failure, but it (...) may help explain why Spinoza holds that there are no contingencies. (shrink)

In this paper, it is shown (1) that there are two schemes for argument from analogy that seem to be competitors but are not, (2) how one of them is based on a distinctive type of similarity premise, (3) how to analyze the notion of similarity using story schemes illustrated by some cases, (4) how arguments from precedent are based on arguments from analogy, and in many instances arguments from classification, and (5) that when similarity is defined by means (...) of episode schemes, we can get a clearer idea of how it integrates with the use of argument from classification and argument from precedent in case-based reasoning by using a dialogue structure. (shrink)

Để xem bóng đá và phát sóng video trực tiếp tốc độ cao, Xoilac là trang web lý tưởng. Đặc biệt, Xoilac không có bất cứ quảng cáo nào, vì vậy người xem vẫn thoải mái thưởng thức trận bóng đá mà không lo bị phân tâm vì bất cứ vấn đề gì. Ngoài ra, Xoilac có đội ngũ dày dặn chuyên môn, luôn đưa ra những nhận định chuẩn xác cho từng trận đấu bóng đá. Với đồ hoạ sinh (...) động, âm thanh lôi cuốn và sống động, Xoilac sẽ lưu lại dấu ấn sâu đậm trong tâm trí người xem bóng đá. (shrink)

1. Introduction In ‘The Refutation of Idealism’, G.E.Moore observed that, "when we try to introspect the sensation of blue, all we can see is the blue: the other element is as if it were diaphanous" (1922; p.25). Many philosophers, but Gilbert Harman (1990, 1996) in particular, have suggested that this observation forms the basis of an argument against qualia, usually called the argument from diaphanousness or transparency.1 But even its friends concede that it is none too clear what (...) the argument from diaphanousness—as I will call it—is (Tye 2000; p.45).2 The purpose of this paper is to formulate the argument, and to assess its merits. My conclusion will be that qualia realists have little to fear from the argument—provided both qualia and diaphanousness are properly understood. (shrink)

Are there really such things as public languages? Are things like English and Urdu mere myths? I urge that, despite an intriguing line of thought which may be extracted from Davidson’s ‘A Nice Derangement of Epitaphs’, philosophers are right to countenance such things in their final ontology. The argument rebutted, which I concede may not have been one which Davidson himself ultimately embraced, is that knowledge of a public language is neither necessary nor sufficient for successful conversational interaction, so (...) that such shared languages are explanatorily otiose. In particular, the ability of interlocutors to communicate in the face of linguistic novelty and error seems to support this conclusion. I respond with two main points. First, initial impressions aside, knowledge of things like English and Urdu is explanatorily necessary. Second, even if successful conversation could be explained without positing such knowledge, we have other reasons to take public languages ontologically seriously. Th.. (shrink)

In recent literature, panpsychism has been defended by appeal to two main arguments: first, an argument from philosophy of mind, according to which panpsychism is the only view which successfully integrates consciousness into the physical world (Strawson 2006; Chalmers 2013); second, an argument from categorical properties, according to which panpsychism offers the only positive account of the categorical or intrinsic nature of physical reality (Seager 2006; Adams 2007; Alter and Nagasawa 2012). Historically, however, panpsychism has also been defended (...) by appeal to a third argument based on considerations about the nature and observability of causation. This argument has not been much discussed in recent times. Here is a concise version from William James: "… the concrete perceptual flux, taken just as it comes, offers in our own activity-situations perfectly comprehensible instances of causal agency … If we took these experiences as the type of what actual causation is, we should have to ascribe to cases of causation outside of our life, to physical cases also, an inwardly experiential nature. In other words, we should have to espouse a so-called “pan-psychic” philosophy" (James 1911: 218). James here suggests that we have direct experience of causation in our own agency. He thereby directly contradicts David Hume, who famously denied that we have any experience of causation. James goes on to claim that if this experience is representative of causation in general, it follows that all causation is mental, and that panpsychism is true. This kind of argument for panpsychism can be called the argument from (experience of) causation. This chapter offers, first, a history of this argument and arguments closely related to it, and second, an analysis of the argument – is it valid, are its premises in any way defensible, and how does it relate to the other, more popular arguments for panpsychism from philosophy of mind and categorical properties? (shrink)

In order to make scientific results relevant to practical decision making, it is often necessary to transfer a result obtained in one set of circumstances—an animal model, a computer simulation, an economic experiment—to another that may differ in relevant respects—for example, to humans, the global climate, or an auction. Such inferences, which we can call extrapolations, are a type of argument by analogy. This essay sketches a new approach to analogical inference that utilizes chain graphs, which resemble directed acyclic (...) graphs (DAGs) except in allowing that nodes may be connected by lines as well as arrows. This chain graph approach generalizes the account of extrapolation I provided in my (2008) book and leads to new insights that integrate the contributions of the other participants of this symposium. More specifically, this approach explicates the role of “fingerprints,” or distinctive markers, as a strategy for avoiding an underdetermination problem having to do with spurious analogies. Moreover, it shows how the extrapolator’s circle, one of the central challenges for extrapolation highlighted in my book, is closely tied to distinctive markers and the Markov condition as it applies to chain graphs. Finally, the approach suggests additional ways in which investigations of a model can provide information about a target that are illustrated by examples concerning nanomaterials in sunscreens and Wendy Parker’s discussion of fingerprints in climate science. (shrink)

This paper shows that low-level generalisations in argument structure constructions are crucial to understanding the concept of alternation: low-level generalisations inform and constrain more schematic generalisations and thus constructional meaning. On the basis of an analysis of the causative alternation in English, and more specifically of the theme, I show that each construction has its own schematic meaning. This analysis is conducted on a dataset composed of 11,554 instances of the intransitive non-causative construction and the transitive causative construction. The (...) identification of lower-level generalisations feeds into the idea that language acquisition is organic and abstractions are formed only gradually from exposure to input. So far, most of the literature on argument structure constructions has focused on the verb itself, and thus fails to capture these generalisations. I make up for this deficit through an in-depth analysis of the causative alternation. (shrink)

The exclusion argument is widely thought to put considerable pressure on dualism if not to refute it outright. We argue to the contrary that, whether or not their position is ultimately true, dualists have a plausible response. The response focuses on the notion of ‘distinctness’ as it occurs in the argument: if 'distinctness' is understood one way, the exclusion principle on which the argument is founded can be denied by the dualist; if it is understood another way, (...) the argument is not persuasive. (shrink)

In a recent article, I criticized Kathrin Glüer and Åsa Wikforss's so‐called “no guidance argument” against the truth norm for belief, for conflating the conditions under which that norm recommends belief with the psychological state one must be in to apply the norm. In response, Glüer and Wikforss have offered a new formulation of the no guidance argument, which makes it apparent that no such conflation is made. However, their new formulation of the argument presupposes a much (...) too narrow understanding of what it takes for a norm to influence behaviour, and betrays a fundamental misunderstanding of the point of the truth norm. Once this is taken into account, it becomes clear that the no guidance argument fails. (shrink)

It is sometimes suggested that expressivism in meta-ethics is to be criticized on grounds which do not themselves concern meta-ethics in particular, but which rather concern philosophy of language more generally. Frank Jackson and Philip Pettit (1998; see also Jackson and Pettit 1999, and Jackson 2001) have recently advanced a novel version of such an argument. They begin by noting that expressivism in its central form makes two claims—that ethical sentences are not truth evaluable, and that to assert an (...) ethical sentence is to express one’s desires or feelings rather than to report a fact. They then argue that, given some plausible premises in the philosophy of language emanating mainly from Locke, the two central claims of expressivism are contradictory: when combined with the plausible premises, they say, the second claim refutes the first. The purpose of this paper is to formulate Jackson and Pettit’s Lockean argument, and to suggest that it fails. (shrink)

The argument from contingency for the existence of God is best understood as a request for an explanation of the total sequence of causes and effects in the universe (‘History’ for short). Many puzzles about how there could be such an explanation arise from the assumption that God is being introduced as one more cause prepended to the sequence of causes that (allegedly) needed explaining. In response to this difficulty, this chapter defends three theses. First, it argues that, if (...) the argument from contingency is to succeed, the explanation of History in terms of God must not be a causal explanation; second, that a particular hypothesis about God’s relation to History—that God is what I call the foundational ground of History—is intelligible and explanatory; third and finally, that the explanatory advantages of this hypothesis cannot be had within the confines of naturalism. (shrink)

There is a theistic argument which is discussed at least twice in the Hume corpus, both times rather perfunctorily. This perfunctoriness has carried over to some of his commentators, who are not always clear as to what the argument is or about the force of Hume’s comments on it. On page 23 of A Letter from a Gentleman to his Friend in Edinburgh Hume calls it “the metaphysical Argument a priori” and in Part 9 of Dialogues concerning (...) Natural Religion simply “the argument a priori”.1 It is the argument of Demea. (shrink)

In the recent literature on confirmation there are two leading approaches to the provision of a probabilistic measure of the degree to which a hypothesis is confirmed by evidence. The first is to construe the degree to which evidence E confirms hypothesis H as a function that is directly proportional to p and inversely proportional to p . I shall refer to this as the probability approach. The second approach construes the notion as a function that is directly proportional to (...) the true-positive rate – the probability of the evidence if the hypothesis is true, p – and inversely proportional to the false-positive rate – the probability of the evidence if the hypothesis is false, p . These reverse conditional probabilities – of the evidence on the truth or falsehood of the hypothesis – are sometimes known as likelihoods. I shall refer to the approach to confirmation that uses them as the likelihood approach.For each of these approaches, there are two obvious options as to how to define the confirmation function. The first is to define it as the difference between the magnitude that is treated as increasing confirmation or p ) and the magnitude that is treated as decreasing confirmation or p ). The second is to define confirmation as the quotient of these two magnitudes.This yields four different measures of confirmation, represented in the following table: Differences RatiosProbabilities PD = p – p1 PR = Graphic2Likelihoods LD = p – p3 LR = Graphic4All these measures agree on whether or not E provides some support for H. Intuitively, we want to say that E provides some support for H just in case learning that E is true would make us assign a higher probability to H, i.e. when p(H …. (shrink)

The legitimacy of government is often linked to its ability to maintain order and secure peace. Thomas Hobbes’ political philosophy provides a clear description of why government is necessary, as human nature and the structures emerging out of human social interaction are such that order and peace will not naturally emerge to a sufficient degree. Hobbes’ general argument is often accepted at the national level, but in this article, I explore why a Hobbesian argument for the international level—an (...) argument for world government—is deducible from his philosophy. Hobbes builds his philosophy on his conception of human nature and argues that individuals’ interests and preferences should be the determinant for evaluating the value of a political entity. By emphasising these aspects of Hobbes’ theory, I argue that several contemporary phenomena suggest that a world government could be preferable to the states system. The cases used are the outbreak of war in Europe in 2022 and the continuing and accelerating environmental crisis. Through this examination, the continued relevance of Hobbes’ political philosophy is demonstrated, and according to Hobbes’ own logic, those who accept the argument should also seek to implement such a solution. (shrink)

What I have tried to do is elicit and disarm the motivations most likely to give rise to the [counterexamples to the principle crucial to Williams' argument]. Only one of these motivations is still viable: the instrumentalist theory of practical reasoning. But because internalism and instrumentalism are, as it has turned out, so very tightly linked, in disarming the motivations for the objection, I have also inventoried, and given reason to reject, what I have found to be the most (...) common conversationally adduced defences of instrumentalism: the appeals to imagination, to dispositional desires, and so on. The issue remaining from the debate over internalism turns out to be whether [instrumentalism is false---i.e. whether] there are patterns of practical inference that are not directed toward the satisfaction of desire. (shrink)

This article elaborates the epistemic indispensability argument, which fully embraces the epistemic contribution of mathematics to science, but rejects the contention that such a contribution is a reason for granting reality to mathematicalia. Section 1 introduces the distinction between ontological and epistemic readings of the indispensability argument. Section 2 outlines some of the main flaws of the first premise of the ontological reading. Section 3 advances the epistemic indispensability argument in view of both applied and pure mathematics. (...) And Sect. 4 makes a case for the epistemic approach, which firstly calls into question the appeal to inference to the best explanation in the defense of the indispensability claim; secondly, distinguishes between mathematical and physical posits; and thirdly, argues that even though some may think that inference to the best explanation works in the postulation of physical posits, no similar considerations are available for postulating mathematicalia. (shrink)

Luck egalitarianism is the view that equality requires the influence of luck on distributive outcomes to be neutralized. The standard version of the view, brute-luck egalitarianism, neutralizes brute luck (the upshot of non-declinable risks) while allowing option luck (the upshot of declinable risks) to stand. This article argues that this view should be rejected in favour of all-luck egalitarianism, which neutralizes brute luck and option luck alike. There are three parts to this overall argument. The first shows that brute-luck (...) egalitarianism’s reasons for neutralizing brute luck’s distributive effects should lead it to also neutralize a subset of option luck. The second demonstrates that various revisions of brute-luck egalitarianism such that it neutralizes this subset (and related ones) are ultimately unsuccessful. The third defends the remaining option of neutralizing option luck generally, as all-luck egalitarianism proposes. (shrink)