Background Over the last decade, the return of results (ROR) in precision medicine research (PMR) has become increasingly routine. Calls for individual rights to research results have extended the “duty to report” from clinically useful genetic information to traits and ancestry results. ROR has thus been reframed as inherently beneficial to research participants, without a needed focus on who benefits and how. This paper addresses this gap, particularly in the context of PMR aimed at increasing participant diversity, by providing investigator (...) and researcher perspectives on and questions about the assumed value of ROR in PMR.Methods Semi-structured interviews with a purposive sample of investigators and researchers across federally funded PMR studies in three national consortia, as well as observations of study activities, focused on how PM researchers conceptualize diversity and implement inclusive practices across research stages, including navigating ROR.Results Interviewees (1) validated the value of ROR as a benefit of PMR, while others (2) questioned the benefit of clinically actionable results to individuals in the absence of sufficient resources for translating findings into health care for diverse and disadvantaged populations; (3) expressed uncertainties in applying the presumed value of ROR as a benefit for non-clinical results; and (4) and debated when the promise of the value of ROR may undermine trust in PMR, and divert efforts to return value beyond ROR.Conclusions Conceptualizations of diversity and inclusion among PM researchers and investigators raise unique ethical questions where unexamined assumptions of the value of ROR inform study recruitment efforts to enroll minoritized and under-represented populations. A lack of consideration for resources and infrastructure necessary to translate ROR into actionable information may hinder trustworthy community-research relationships. Thus, we argue for a more intentional interrogation of ROR practices as an offer of benefit and for whom. (shrink)

In How to Talk to a Science Denier, Lee McIntyre tells the story of his own adventures in talking face to face with science deniers and their victims-including a Flat Earth convention in Denver, coal miners in rural Pennsylvania, and fishermen in the Maldives-and what he learned from the experience.

This paper explains the nature and origin of what I am calling Transgressive Realism, a middle path between realism and anti-realism which tries to combine their strengths while avoiding their weaknesses. Kierkegaard created the position by merging Hegel’s insistence that we must have some kind of contact with anything we can call real (thus rejecting noumena), with Kant’s belief that reality fundamentally exceeds our understanding; human reason should not be the criterion of the real. The result is the idea that (...) our most vivid encounters with reality come in experiences that shatter our categories, the way God’s commandment to kill Isaac irreconcilably clashes with the best understanding of ethics we are capable of. I explain the genesis of this idea, and then show it at work in Heidegger and Levinas’ thought. Understanding this position illuminates important aspects of the history of continental philosophy and offers a new perspective on realism. (shrink)

Both Watts and Beit-Hallahmi are enthusiastic about attachment theory as an important contribution to the psychology of religion, but they raise very different criticisms regarding other aspects of the book. I respond to Beit-Hallahmi by defending my assertion that a scientific approach to psychology of religion need not lead to the conclusion, nor rest on the premise, that the beliefs under study are ontologically false. I argue further that this "veridicality trap" has deep roots in prevailing, deeply mistaken assumptions about (...) how the mind/brain works, and show how an evolutionary approach clearly exposes such reasoning as fallacious and offers a powerful, alternative perspective on the problem. In response to Watts, I defend evolutionary psychology against the charge that it is not sufficiently empirical, and argue that the computational cognitive approach he prefers should be seen as complementary to an evolutionary approach rather than an alternative to it. (shrink)

Cool Characters tells the story of American political irony from World War II to the present: how irony came to seem politically subversive for American countercultural rebels; how mainstream culture allegedly co-opted countercultural irony; how irony became part of major critical theories of postmodernism; and how -- starting in the late 1980s -- innovative writers developed an idea of "postirony" with the hope of overcoming the political limitations of postmodern irony. To chart the shift from irony to postirony, and show (...) what relationship culture has to politics, the book offers intensive analyses of important American countercultural figures: the hipster, the punk, a figure the author calls "the believer," the coolhunter, and the occupier; and new interpretations of important works by Ralph Ellison, Thomas Pynchon, William S. Burroughs, Kathy Acker, Michael Muhammad Knight, David Foster Wallace, Dave Eggers, Alex Shakar, William Gibson, Jennifer Egan, Jonathan Lethem, and Rachel Kushner."--Provided by publisher. (shrink)

이 논문은 데이빗 루이스의 시간적 부분 이론(temporal part theory)과 물질적 구성(material consitution)에 대한 반 인와겐의 입장에 대한 논의를 출발점으로 삼는다. 먼저 필자는 루이스의 시간적 부분이론을 반박한다. 루이스의 이론의 핵심적인 내용을 똑같이 반영(mirror)하면서도 그 이론과 상충하는 이론을 구성하고 이 두 이론 중 어느 한 쪽을 선택하는 것은 결국은 임의적인(arbitrary) 결정을 하는 것인데 이 사실은 이 두 이론 모두를 매력적이지 않게 만든다고 주장한다. 이 두 이론을 모두 거부한다면 우리는 사물을 (특별히 문제되는 사물이 ‘자아’라면 더더욱) 어디에 위치시켜야 하는지 새로운 가능성을 탐색해 보게 된다. (...) 다음으로 이 논문은 떨어지지 않은 임의적인 부분(arbitrary undetached part)에 대한 반 인와 겐의 논증을 살펴보고 그 논증을 준거점으로 삼아 물질적 구성(material consitution)에 대한 여러 논문들에 등장한 이론적 가능성을 일별한다. 필자는 이 여러 입장들 뒤에 근본적인 전제로 기능하고 있는 철학적 원자론(philosophical atomism)과 그 이론이 내포하는 환원주의적 접근이 자아가 존재하고 시간 속에 지속한다(endure through time)는 근본적인 믿음을 포함하는 ‘자아의 선차성’ 논제를 위협한다는 것을 지적하고 루이스의 이론에 대한 논의에서 얻은 결론과 결합하여, 상당히 이상해보이지만 고려해볼만한 이론적 가능성으로 자아가 시간 속에 지속하는 영차원의(zero-dimensional) 존재라는 가능성을 제기한다. (shrink)

Popper Proposed the criterion of falsifiability as a solution to the problem of demarcation i.e. of distinguishing science from pseudo-science and not, as many of his contemporaries in the Vienna Circle mistook it to be, a solution to the quite different problem with which they themselves were preoccupied, viz. of providing a criterion of meaning to distinguish the meaningful from the meaningless. While the positivists were concerned to damn metaphysics and exalt science, by identifying the empirically verifiable with the meaningful, (...) Popper was concerned to separate science from scientism, to damn astrology and to extol astronomy. In other words his preoccupation belongs not to the philosophy of language but to the philosophy of science. (shrink)

ABSTRACTIn the Timaeus, Plato explicitly defines time as “the moving image of eternity”. This proposition affirms actually that time reflects the eternal that embodies the rational and lawful principle – namely the logos of proportionality – in the motion and change of visible objects in the universe. In other words,time determines the principle that every mutable being must follow to participate in the rational and nomological order of existence; the absolute logos which is given by God is hence intrinsic to (...) time. This idea of time is echoed by the theories of Augustine and Husserl. Both philosophers inherited some of Plato’s metaphysical views, and each of them developed a distinctive theory of the relations between Being, time, and the absolute logos. This paper attempts to compare their theories and to defend the following claim: Augustine fo-cuses on the immutable representation of time which is regarded as the image or reflection of God’s absolute logos, and explains temporal phenome... (shrink)

In the following essay, I argue for an alternative anthropocentrism that, eschewing failed appeals to traditional moral principle, takes (a) as its point of departure the cognitive, perceptual, emotive, somatic, and epistemic conditions of our existence as members of Homo sapiens, and (b) one feature of our experience of/under these conditions particularly seriously as an avenue toward articulating this alternative, the capacity for aesthetic appreciation. To this end, I will explore, but ultimately reject philosopher Allen Carlson's ecological aesthetics, and I (...) will adopt with modification aspects of the work of Ronnie Hawkins, Val Plumwood, and Donna Haraway. My central claim is that, equipped with a better understanding of our interdependent relationship to/within human and nonhuman nature, an understanding made especially available to those who occupy situations imbued by subjugation, we can come to understand our human-centeredness not as a justification of entitlement, but as an opportunity for critical self-reflection upon those actions which endanger the ecological conditions of human and nonhuman being. I suggest, then, that developing criteria for an aesthetic appreciation ground in such a centeredness can make a vital contribution to a more ecologically defensible moral and political activism. (shrink)

African Philosophy is a collection of previously unpublished essays that address epistemological and metaphysical concerns that have emerged from the sub-Saharan regions of Africa. The primary focus of the book is on traditional African conceptions of mind, person, personal identity, truth, knowledge, understanding, objectivity, and reality. The collection also discusses traditional African conceptions of causation, destiny, and free will.

This paper deals with the semantics and meta-semantics for ordinary names in fiction. It has recently been argued by some philosophers that when ordinary names are used in fictional contexts, they change their semantic contents and work as fictional names in general. In this paper, I argue that there is no compelling reason to believe that such reference changes occur and defend the view that whether those names refer to real or fictional objects depends on which semantic intentions speakers have.

Long awaited after No Future, and making queer theory controversial again, Lee Edelman's Bad Education proposes a queerness without positive identity-a queerness understood as a figural name for the void, itself unnamable, around which the social order takes shape. Like Blackness, woman, incest, and sex, queerness, as Edelman explains it, designates the antagonism, the structuring negativity, preventing that order from achieving coherence. But when certain types of persons get read as literalizing queerness, the negation of their negativity can seem to (...) resolve the social antagonism and totalize community. By translating the nothing of queerness into the something of "the queer," the order of meaning defends against the senselessness that undoes it, thus mirroring, Edelman argues, education's response to queerness: its sublimation of irony into the meaningfulness of a world. Putting queerness in relation to Lacan's "ab-sens" and in dialogue with feminist and Afropessimist thought, Edelman reads works by Shakespeare, Jacobs, Almodovar, Lemmons, and Haneke, among others, to show why queer theory's engagement with queerness necessarily results in a bad education that is destined to teach us nothing. (shrink)

For more than a century, scholars have believed that Italian humanism was predominantly civic in outlook. Often serving in communal government, fourteenth-century humanists like Albertino Mussato and Coluccio Saltuati are said to have derived from their reading of the Latin classics a rhetoric of republican liberty that was opposed to the "tyranny" of neighbouring signori and of the German emperors. In this ground-breaking study, Alexander Lee challenges this long-held belief. From the death of Frederick II in 1250 to the failure (...) of Rupert of the Palatinate's ill-fated expedition in 1402, Lee argues, the humanists nurtured a consistent and powerful affection for the Holy Roman Empire. Though this was articulated in a variety of different ways, it was nevertheless driven more by political conviction than by cultural concerns. Surrounded by endless conflict--both within and between city-states--the humanists eagerly embraced the Empire as the surest guarantee of peace and liberty, and lost no opportunity to invoke its protection. Indeed, as Lee shows, the most ardent appeals to imperial authority were made not by "signorial" humanists, but by humanists in the service of communal regimes. The first comprehensive, synoptic study of humanistic ideas of Empire in the period c.1250-1402, this volume offers a radically new interpretation of fourteenth-century political thought, and raises wide-ranging questions about the foundations of modern constitutional ideas. As such, it is essential reading not just for students of Renaissance Italy and the history of political thought, but for all those interested in understanding the origins of liberty. (shrink)

This essay discusses how ontological commitments within modern Western culture are no less problematic than those within traditional African cultures. Each posits unobservable entities to explain the experiential world, and neither has ready access to those posits held as grounding or as otherwise determining what is experienced. It looks at the conceptions of persons in Western and African traditions and suggests that each tradition can learn from the other.

Research has found many positive benefits to person‐organization (PO) fit, for both individuals and the organization. However, PO misfit has received far less attention in the literature. In this article, we look specifically at PO misfit caused by the differing political values and beliefs of the CEO and employee. We argue that CEO activism influences employee perceptions of ideological misfit (IM), whereby differing political beliefs between employees and their activist CEO can impact workplace outcomes. We consider how peer group reactions, (...) ethical climate, external needs fulfillment, and moral identity serve as boundary conditions for perceptions of PO misfit and related organizational outcomes. We also examine antecedents of CEO activism. Drawing on academic literature from both the micro and macro perspectives of management research, we introduce a conceptual model and discuss implications for the firm and its employees. (shrink)

Some two hundred years ago the course of philosophy was changed, and we shall in this paper take it for granted that we cannot return to an earlier standpoint. We have left behind, not simply the notion that we can penetrate the nature of things by pure reason, but also the idea that our knowledge moves in ever-widening circles of objectivity toward a standpointless comprehension of things. Absolute comprehension is a mere regulative idea, although even that is misleading if it (...) suggests that we could somehow speculate on what it would be like to circumscribe the world in some enormous final circle. The idea that the world is inexhaustible is part of this turning point, but that is in itself not a new idea. What is more to the point than an indefinitely long parade of new facts is the permanent possibility—even within the limits of some absolute but undiscovered conditions of thinking—of revising our human schemes, or, if you wish, of revising our concepts of what, relative to schemata, is to count as an element or part of a system, or as an instance of a general law. (shrink)

Unlike natural agents, artificial agents are, to varying extent, designed according to sets of principles or assumptions. We argue that the designer’s philosophical position on truth, belief and knowledge has far reaching implications for the design and performance of the resulting agents. Of the many sources of design information and background we believe philosophical theories are under-rated as valuable influences on the design process. To explore this idea we have implemented some computer-based agents with their control algorithms inspired by two (...) strongly contrasting philosophical positions. A series of experiments on these agents shows that, despite having common tasks and goals, the behaviour of the agents is markedly different and this can be attributed to their individual approaches to belief and knowledge. We discuss these findings and their support for the view that epistemological theories have a particular relevance for artificial agent design. (shrink)

Without doubt, Weighing Lives, like its precursor, Weighing Goods, is an excellent and thought-provoking piece of work. In the first place, it addresses a question of the most fundamental importance, namely: how should we aggregate the well-being of past, present and future members of the human race under the various possible states of the world that may, in the event, prevail? This involves, amongst other things, dealing with questions of aggregation across time, people and different states of the world; the (...) issue of what constitutes a “neutral” state of well-being and what is, in fact, the value of continuing to survive. (shrink)

This article seeks to model the agenda-setting strategies of stakeholders equipped with online and other media in three cases involving protests against multinational corporations (MNCs). Our theoretical objective is to widen agenda-setting theory to a dynamic and nonlinear networked stakeholder context, in which stakeholder-controlled media assume part of the role previously ascribed to mainstream media (MSM). We suggest system dynamics (SD) methodology as a tool to analyse complex stakeholder interactions and the effects of their agendas on other stakeholders. We find (...) that largely similar dynamics of interactions occur among stakeholders in these cases, and that the costs for managements of maintaining their agendas steadily rises. We conclude that the “web of watchdogs” comprises a powerful reason for managers to engage in responsibility negotiations with their stakeholders. (shrink)

I defend Kant’s moral psychology against John R. Silber’s argument that Kant cannot account for the radical evil of Hitler. Silber’s argument cannot be maintained, I argue, if Kant’s account of theological and moral fanaticism, and the personality of the moral fanatic, are taken into account. I contend that Kant’s writings support an analogy between the fanatical pursuit of religious and moral ideals and Hitler’s fanatical pursuit of an ideal of racial purity. I conclude that Kant’s account of moral fanaticism (...) is adequate to account for the actions and moral psychology of Hitler. (shrink)

It is well known that Hume gave a powerful skeptical argument against induction. Many philosophers think that even though Hume’s description of induction is inadequate in some respects, his skeptical argument is still irrefutable. However, Okasha argues that this cannot be right: Once we adequately describe what we are doing with induction, Hume’s skeptical argument cannot be applied to this adequate description of induction any more. In this paper, in opposition to Okasha, I will argue that Hume’s skeptical argument still (...) can be applied even on the ‘adequate’ description of induction. (shrink)