Whole genome sequencing and SNP genotyping arrays can paint strikingly different pictures of demographic history and natural selection. This is because genotyping arrays contain biased sets of pre‐ascertained SNPs. In this short review, we use comparisons between high‐coverage whole genome sequences of African hunter‐gatherers and data from genotyping arrays to highlight how SNP ascertainment bias distorts population genetic inferences. Sample sizes and the populations in which SNPs are discovered affect the characteristics of observed variants. We find that SNPs on genotyping (...) arrays tend to be older and present in multiple populations. In addition, genotyping arrays cause allele frequency distributions to be shifted towards intermediate frequency alleles, and estimates of linkage disequilibrium are modified. Since population genetic analyses depend on allele frequencies, it is imperative that researchers are aware of the effects of SNP ascertainment bias. With this in mind, we describe multiple ways to correct for SNP ascertainment bias. (shrink)

"Well-being" signifies the good life, the life which is good for the person whose life it is. I have argued that well-being consists in a wholehearted and successful pursuit of valuable relationships and goals. This view, a little modified, is defended , but the main aim of the article is to consider the role of well-being in practical thought. In particular I will examine a suggestion which says that when we care about people, and when we ought to care about (...) people, what we do, or ought to, care about is their well-being. The suggestion is indifferent to who cares and who is cared for. People may care, perhaps ought to care, about themselves, and they may care, perhaps ought to care, about people with whom they have, or ought to have special bonds, and finally they may care, perhaps ought to care, about other people generally. In all cases what they care, or ought to care, about is the wellbeing of the relevant people, themselves or others. I will argue that the suggestion is misleading, and the role of well-being in both personal and ethical life is much more modest. (shrink)

Adaptationists explain the evolution of religion from the cooperative effects of religious commitments, but which cooperation problem does religion evolve to solve? I focus on a class of symmetrical coordination problems for which there are two pure Nash equilibriums: (1) ALL COOPERATE, which is efficient but relies on full cooperation; (2) ALL DEFECT, which is inefficient but pays regardless of what others choose. Formal and experimental studies reveal that for such risky coordination problems, only the defection equilibrium is evolutionarily stable. (...) The following makes sense of otherwise puzzling properties of religious cognition and cultures as features of cooperative designs that evolve to stabilise such risky exchange. The model is interesting because it explains lingering puzzles in the data on religion, and better integrates evolutionary theories of religion with recent, well-motivated models of cooperative niche construction. (shrink)

Social Constructivism and the Philosophy of Science by Andre Kukla The Social Construction of What? by Ian Hacking.

Most causal discovery algorithms in the literature exploit an assumption usually referred to as the Causal Faithfulness or Stability Condition. In this paper, we highlight two components of the condition used in constraint-based algorithms, which we call “Adjacency-Faithfulness” and “Orientation- Faithfulness.” We point out that assuming Adjacency-Faithfulness is true, it is possible to test the validity of Orientation- Faithfulness. Motivated by this observation, we explore the consequence of making only the Adjacency-Faithfulness assumption. We show that the familiar PC algorithm has (...) to be modified to be correct under the weaker, Adjacency-Faithfulness assumption. The modified algorithm, called Conservative PC (CPC), checks whether Orientation- Faithfulness holds in the orientation phase, and if not, avoids drawing certain causal conclusions the PC algorithm would draw. Howtion: ever, if the stronger, standard causal Faith-. (shrink)

ספר ויקרא, או תורת כוהנים, נראה היום פחות מעניין מאשר ספרי-קודש אחרים, כי הוא ספר מצוות - הוא כולל כארבעים אחוז מכל תרי"ג המצוות - ואף במידה רבה מצוות שאינן בתוקף מאז חורבן בית-המקדש. אך יש בו עניין, שכן הוא מוכר כספר השלם ביותר מבחינת סגנונו ותכנו, ואולי אף בכך שעריכתו כנראה עתיקה ביותר - לא לדעת דון יצחק אברבנאל, שכן הוא לא הטיל בספק כי תורה נתנה למשה מפי הגבורה - אמנם לא בסיני אך בכל-זאת למשה מפי הגבורה. החוקרים (...) המתעלמים מדעה זו.. (shrink)

A variety of approaches have appeared in academic literature and in design practice representing “ethics-first” methods. These approaches typically focus on clarifying the normative dimensions of design, or outlining strategies for explicitly incorporating values into design. While this body of literature has developed considerably over the last 20 years, two themes central to the endeavour of ethics and values in design (E + VID) have yet to be systematically discussed in relation to each other: (a) designer agency, and (b) the (...) strength of normative claims informing the design process. To address this gap, we undertook a structured review of leading E + VID approaches and critiques, and classified them according to their positions on normative strength, and views regarding designer agency. We identified 18 distinct approaches and 13 critiques that met the inclusion criteria for our review. Included papers were distributed across the spectrum of views regarding normative strength, and we found that no approaches and only one critique represented a view characteristic of “low” designer agency. We suggest that the absence of “low” designer agency approaches results in the neglect of crucial influences on design as targets of intervention by designers. We conclude with suggestions for future research that might illuminate strategies to achieve ethical design in information mature societies, and argue that without attending to the tensions raised by balancing normatively “strong” visions of the future with limitations imposed on designer agency in corporate-driven design settings, “meaningful” ethical design will continue to encounter challenges in practice. (shrink)

This survey of major developments in North American philosophy of science begins with the mid-1960s consolidation of the disciplinary synthesis of internalist history and philosophy of science (HPS) as a response to criticisms of logical empiricism. These developments are grouped for discussion under the following headings: historical metamethodologies, scientific realisms, philosophies of the special sciences, revivals of empiricism, cognitivist naturalisms, social epistemologies, feminist theories of science, studies of experiment and the disunity of science, and studies of science as practice and (...) culture. A unifying theme of the survey is the relation between historical metamethodologists and scientific realists, which dominated philosophical work in the late 1970s. I argue that many of the alternative cognitive naturalisms, social epistemologies, and feminist theories that have been proposed can be understood as analogues to the differences between metamethodological theories of scientific rationality and realist accounts of successful reference to real causal processes. Recent work on experiment, scientific practice, and the culture of science may, however, challenge the underlying conception of the field according to which realism and historical rationalism (or their descendants) are the important alternatives available, and thus may take philosophy of science in new directions. (shrink)

Journal of Philosophy of Education, EarlyView.

The aim of this paper is twofold: first to sketch a framework for classifying a wide range of conceptions of scientific objectivity and second to present and defend a conception of scientific objectivity that fills a neglected niche in the resulting hierarchy of viewpoints. Roughly speaking, the proposed ideal of scientific objectivity is effectiveness in the informal but technical sense of an effective method. Science progresses when "higher levels of communicative discourse" are reached by transforming subjective judgments regarding the generation (...) and reduction of data or the testing of theories into objective decision procedures that are automatic or mechanical. (shrink)

Patients who are imminently dying sometimes experience symptoms refractory to traditional palliative interventions, and in rare cases, continuous sedation is offered. Samuel H. LiPuma, in a recent article in this Journal, argues that continuous sedation until death is equivalent to physician-assisted suicide/euthanasia based on a higher brain neocortical definition of death. We contest his position that continuous sedation involves killing and offer four objections to the equivalency thesis. First, sedation practices are proportional in a way that physician-assisted suicide/euthanasia is not. (...) Second, continuous sedation may not entirely abolish consciousness. Third, LiPuma’s particular version of higher brain neocortical death relies on an implausibly weak construal of irreversibility—a position that is especially problematic in the case of continuous sedation. Finally, we explain why continuous sedation until death is not functionally equivalent to neocortical death and, hence, physician-assisted suicide/euthanasia. Concluding remarks review the differences between these two end-of-life practices. (shrink)

Since there is no normal pagination on a web page, I assign in lieu of that paragraph numbers, included in brackets and placed flush right, just above the paragraph, for purposes of scholarly reference: they are not in the previously published version above. Apart from that the texts are substantially identical.

This is a copy of the Proceedings version of a paper presented at the Workshop on Computational Intelligence and Semiotics, organized by João Queiroz and Ricardo Gudwin, held at Itaú Cultural, São Paulo, Brazil, on 8-9 October, 2002. (This version contains material not actually delivered at the conference.) Queiroz and Gudwin will be releasing the Proceedings volume on a..

In Wittgenstein on Meaning, Colin McGinn argues that the skeptical argument that Kripke distills from Wittgenstein's rule-following considerations generates at most what might be called meaning skepticism (the non-factuality view of meaning), and not concept skepticism (the non-factuality view of concepts). If correct, this would mean the skeptical reasoning is far less significant than Kripke thinks. Others have seemed to agree with McGinn. I argue that McGinn is wrong here--that, in fact, Kripke's skeptical reasoning has a straightforward extension to concepts. (...) Whether the reasoning succeeds, however, is another matter, which I do not address here. (shrink)

Why have radical political theorists, whose thinking inspired mass movements for democracy, been so suspicious of political plurality? According to Joseph Schwartz, their doubts were involved with an effort to transcend politics. Mistakenly equating all social difference with the harmful way in which particular interests dominated marketplace societies, radical thinkers sought a comprehensive set of "true human interests" that would completely abolish political strife. In extensive analyses of Rousseau, Hegel, Marx, Lenin, and Arendt, Schwartz seeks to mediate the radical (...) critique of democratic capitalist societies with the concern for pluralism evidenced in both liberal and postmodern thought. He thus escapes the authoritarian potential of the radical position, while appropriating its more democratic implications. In Schwartz's view, a reconstructed radical democratic theory of politics must sustain liberalism's defense of individual rights and social pluralism, while redressing the liberal failure to question structural inequalities. In proposing such a theory, he criticizes communitarianism for its premodern longing for a monolithic, virtuous society, and challenges the "politics of difference" for its failure to question the undemocratic terrain of power on which "difference" is constructed. In conclusion, he maintains that an equitable distribution of power and resources among social groups necessitates not the transcendence of politics but its democratic expansion. (shrink)

Epistemological issues have inevitably been perennial issues for theism. For any claim to have insight into the nature and acts of the divine requires some sort of substantiation. And the appeal to faith typically made to meet this demand is often unconvincing. This raises a fundamental question: what could constitute proper grounds for theistic belief? In attempting to anwser this question, we will need to address the underlying epistemic issue of what justifies commitment to any world–view.

The symposium on Francesco Guala’s Understanding Institutions was thought provoking. Five critical papers took issue with Guala’s reconciliation of the game-theoretical view of institutions and the rule-governed view. We offer some critical commentary that adopts a different perspective. We agree that institutions are central to social life and, thus, also to the social sciences; they are also prior to and more fundamental than individuals. We add some historical points on the ways previous philosophers thought about institutions, and we come at (...) this from a philosophical viewpoint that is not that of analytic philosophy but rather that of Popper’s critical rationalism. In that framework, we espouse an idea of the relation between philosophy and the philosophy of science that is different from that of Guala and his commentators, and we recommend a reformist philosophy of institutions that is neither radical nor traditionalist and that makes better sense of the institution of the scholarly symposium than do... (shrink)

Positivists identify science and certainty and in the name of the utter rationality of science deny that it rests on speculative presuppositions. The Logical Positivists took a step further and tried to show such presuppositions really no presuppositions at all but rather poorly worded sentences. Rules of sentence formation, however, rest on the presuppositions about the nature of language. This makes us unable to determine the status of mathematics, which is these days particularly irksome since this question is now-since Abraham (...) Robinson-one that mathematicians cannot ignore. Since mathematics is the paradigm of a logical discourse, logic must offer a system adequate enough to serve mathematics. This fact makes it difficult to avoid making question-begging moves in both mathematics and logic. We must therefore view the rationality of logic as partial and hope it is stepwise improvable. The theory of rationality thus turns to be the major presupposition of logic, and one which has ample metaphysical background to it. The very supposition, basic to all logic, that language is divisible into form andcontent is under suspicion-mathematics perhaps belongs to neither. (shrink)

Peter Lassman and Irving Velody, with Herminio Martins, eds., Max Weber's " Science as a Vocation ." Unwin Hyman, London, 1989. Pp. 213, US$49.95.

The tu quoque argument is the argument that since in the end rationalism rests on an irrational choice of and commitment to rationality, rationalism is as irrational as any other commitment. Popper's and Polanyi's philosophies of science both accept the argument, and have on that account many similarities; yet Popper manages to remain a rationalist whereas Polanyi decided for an irrationalist version of rationalism. This is more marked in works of their respective followers, W. W. Bartley III and Thomas S. (...) Kuhn. Bartley declares the rationalist's very openness to criticism open to criticism, in the hope of rendering Popper's critical rationalism quite comprehensive. Kuhn makes rationality depend on the existence of an accepted model for scientific research (paradigm), thus rendering Polanyi's view of the authority of scientific leadership a sine qua non for scientific progress. The question raised here is, in what sense is a rationalist committed to his rationality, or an irrationalist to his specific axiom ? The tradition views only the life?long commitment as real. Viewing rationality as experimental open?mindedness, we may consider a rationalist unable to retreat into any life?long commitment ? even commitment to science. In this way the logic of the tu quoque argument is made irrelevant: anyone able to face the choice between rationality and commitment is already beyond such a choice; it is one thing to be still naïve and another ? and paradoxical ? thing to return to one's naïveté. (shrink)

Given the excessive moralization of human rights and their universal ideologization, which has led to unfortunate consequences such as erasure of cultural differences and standardization, given the right, and even the duty, to intervene (the right of the strongest), and the craze for ‘democracy’ despite the will of peoples, the time has come to undertake an academic analysis of the founding texts in order to make them intelligible, in spite of the fact that human rights have become a bible. Even (...) the revealed word of the Bible is scrutinized by exegetical analysis, historical criticism and hermeneutics, which have not stopped it surviving. It should be the same for human rights. (shrink)

This collection of literature attempts to compile many of the classic, timeless works that have stood the test of time and offer them at a reduced, affordable price, in an attractive volume so that everyone can enjoy them.

If we can save the lives of only one of multiple groups of people, we might be inclined simply to save whichever group is largest. We may worry, though, that automatically saving the largest group fails to take each saveable individual sufficiently into account, offering some of these individuals no chance at all of being rescued. Still wanting to give larger groups higher chances of survival, we may then say that we ought to employ a proportionally weighted lottery to determine (...) which group to save. In this paper, I argue that this would be a mistake. Given the most plausible way of specifying it, the weighted-lottery view itself fails to treat each saveable individual with equal moral respect. (shrink)

The Internet furore over Intel’s flawed Pentium chip provides an important case study of the ethical ambiguity of internet communications and the legitimacy of certain forms of “electronic activism”. Joseph Badaracco, Jr., is John Shad Professor of Business Ethics at the Harvard Business School and his co‐author is a former Research Associate at Harvard and currently on the editorial staff of Inc. magazine.

This article examines the phenomenological structures of the homo temporalis filtered through Augustine's illuminating, if unsystematic, insights on temporality and the imago Dei. It situates such a phenomenological interpretation of the Augustinian self in view of current interpretations that polarize or split the Augustinian self into an either/or scheme—either an “interior” self or an “exterior” self. Given this imbalance, the article suggests that a phenomenological evaluation of Augustine brings to light how interior and exterior spheres are deeply integrated. The article (...) elaborates this position by contending that the self's temporal streaming within the exterior world‐horizon is inescapable because it reflects basic constituents of a self created by God which is nevertheless capable of contemplating a God who transcends time. This seeming paradox is resolved by recourse to what is described as the “double entry” of the self. The temporal streaming of the self in the world‐horizon is porous to the eternal inwardly ; the eternal entry is thus interior and analyzable in terms of a non‐reflective self‐awareness on display in Augustine's De Trinitate; and finally Augustine's understanding of the temporality of faith indicates how the self of faith can be lived in light of Heidegger's emphasis on the future and Husserl's emphasis on the past. (shrink)