The prevailing model for encouraging innovation based on patents and market-oriented raises at least two economic and ethical issues: it imposes barriers on individuals and developing countries governments' access to medicines by defining prices that do not match their income, and the unavailability of new or appropriate products to address the health problems of these populations. In the last decade, this scenario has undergone some changes due to the emergence of new actors, the contribution of aid resources, the introduction to (...) the market of new products against neglected diseases, the development of new governmental healthcare policies and research programs, etc. One example of such initiatives is the Fixed-Dose Artesunate Combination Therapy (FACT) project consortium, which brought together institutions with different natures from both the North and the South, for the development of two antimalarial fixed-dose combinations recommended by the WHO – artesunate-amodiaquine (ASAQ) and artesunate-mefloquine (ASMQ). This paper proposes to describe and analyze the ASMQ consortium, which is the result of a new pharmaceutical development approach, based on a different paradigm – needs-driven instead of market-driven –, collaborative, with strategic participation of institutions from the South, funded by alternative resources (public and philanthropic). Thus, it represents an interesting object of study for bioethical debates on intellectual property and innovation, and its analysis is justified in light of the current debate on ways of stimulating needs-driven pharmaceutical innovation. (shrink)

Parable is a literary genre. The knowledge of a literary parable makes us cognizant of the use of a technique used by the great philosophers to make known or transfer new ideas by making analogies or putting on one side a known fact to communicate a new or something incomprehensible. Jesus used the parable constantly, in his preaching and in the proclamation of the Kingdom of Heaven.

The activity of the left and right central pattern generators is efficiently coordinated during locomotion. To achieve this coordination, the interplay between the CPG controlling one leg and that controlling another must be present. Previous findings in aquatic vertebrates and mammalians suggest that the alternate activation of the left and right CPGs is mediated by the commissural interneurons crossing the midline of the spinal cord. Especially, V0 commissural interneurons mediate crossed inhibition during the alternative activity of the left and right (...) CPGs. Even in humans, phase-dependent modulation of the crossed afferent inhibition during gait has been reported. Based on those previous findings, crossed inhibition of the CPG in one leg side caused by the activation of the contralateral CPG is a possible mechanism underlying the coordination of the anti-phase rhythmic movement of the legs. It has been hypothesized that the activity of the flexor half center in the CPG inhibits the contralateral flexor half center, but crossed inhibition of the extensor half center is not present because of the existence of the double limb support during gait. Nevertheless, previous findings on the phase-dependent crossed inhibition during anti-phase bilateral movement of the legs are not in line with this hypothesis. For example, extensor activity caused crossed inhibition of the flexor half center during bilateral cycling of the legs. In another study, the ankle extensor was inhibited at the period switching from extension to flexion during anti-phase rhythmic movement of the ankles. In this review article, I provide a critical discussion about crossed inhibition mediating the coordination of the anti-phase bilateral rhythmic movement of the legs. (shrink)

We consider the problem of fair allocation in economies with indivisible goods. Our primary concept is that of an envy-free allocation, that is, an allocation such that no agent would prefer anyone else's bundle to his own. Since there typically is a large set (a continuum) of such allocations, the need arises to identify well-behaved selections from the no-envy solution. First we establish the non-existence of ‘population monotonic’ selections. Then we propose a variety of selections motivated by intuitive considerations of (...) fairness. (shrink)

Master Sorai's Responsals was to eighteenth-century Japan what The Prince was to Renaissance Italy. Like Machiavelli, Ogyu Sorai was a humanist scholar who served a prince and drew on his experiences as a house philosopher and on his vast knowledge of history and political affairs in his work. In 1720, when he began to write the letters that comprise this text, the Tokugawa regime was more than a hundred years old and beset with grave administrative and fiscal problems, about which (...) Sorai had much to say.Samuel Yamashita's impressive translation of this work offers modern readers a rare glimpse of the prevailing political discourse of the day and the specific concepts that rulers had at their disposal as they struggled to manage their domains, find talented men for their bureaucracies, create new sources of revenue, and keep their subjects well fed and happy.Sorai himself, of course, is a presence in the text. He is by tunes earnest, frank, impatient, utterly confident, and occasionally condescending. Unlike his Renaissance counterpart, he is something of an optimist: he was convinced that the introduction of archaic Chinese culture and institutions to Japan would solve its myriad problems.Well-versed in Chinese history, philosophy, religion, medicine, and belles lettres, Sorai holds forth on everything from archaic Chinese divination to Sung poetry and prose. He offers advice on how to become a Confucian gentleman, how to learn to read classical Chinese, and which books to read and which to avoid. He even discusses his belief in a sentient, Chinese-style "heaven," a topic not well understood by modern scholars. Long regarded as one of Sorai's best works, Master Sorai's Reponsals bristles with the sharp and clear opinions of the most influential thinker of Tokugawa Japan. (shrink)

We have developed a broadcasting agent system, public opinion channel (POC) caster, which generates understandable conversational form from text-based documents. The POC caster circulates the opinions of community members by using conversational form in a broadcasting system on the Internet. We evaluated its transformation rules in two experiments. In experiment 1, we examined our transformation rules for conversational form in relation to sentence length. Twenty-four participants listened to two types of sentence (long sentences and short sentences) with conversational form or (...) with single speech. In experiment 2, we investigated the relationship between conversational form and the user’s knowledge level. Forty-two participants (21 with a high knowledge level and 21 with a low knowledge level) were selected for a knowledge task and listened to two kinds of sentence (sentences about a well-known topic or sentences about an unfamiliar topic). Our results indicate that the conversational form aided comprehension, especially for long sentences and when users had little knowledge about the topic. We explore possible explanations and implications of these results with regard to human cognition and text comprehension. (shrink)

Master Sorai's Responsals was to eighteenth-century Japan what The Prince was to Renaissance Italy. Like Machiavelli, Ogyu Sorai was a humanist scholar who served a prince and drew on his experiences as a house philosopher and on his vast knowledge of history and political affairs in his work. In 1720, when he began to write the letters that comprise this text, the Tokugawa regime was more than a hundred years old and beset with grave administrative and fiscal problems, about which (...) Sorai had much to say.Samuel Yamashita's impressive translation of this work offers modern readers a rare glimpse of the prevailing political discourse of the day and the specific concepts that rulers had at their disposal as they struggled to manage their domains, find talented men for their bureaucracies, create new sources of revenue, and keep their subjects well fed and happy.Sorai himself, of course, is a presence in the text. He is by tunes earnest, frank, impatient, utterly confident, and occasionally condescending. Unlike his Renaissance counterpart, he is something of an optimist: he was convinced that the introduction of archaic Chinese culture and institutions to Japan would solve its myriad problems.Well-versed in Chinese history, philosophy, religion, medicine, and belles lettres, Sorai holds forth on everything from archaic Chinese divination to Sung poetry and prose. He offers advice on how to become a Confucian gentleman, how to learn to read classical Chinese, and which books to read and which to avoid. He even discusses his belief in a sentient, Chinese-style "heaven," a topic not well understood by modern scholars. Long regarded as one of Sorai's best works, Master Sorai's Reponsals bristles with the sharp and clear opinions of the most influential thinker of Tokugawa Japan. (shrink)

The book explores the ways in which Jean Jacques Rousseau envisaged time as a diagnostic tool for understanding the state of society and the predicaments of modernity. Central to his conceptualization of both nature and history, time also plays a unique role in Rousseau's literary and aesthetic explorations of selfhood and effect. The book brings into dialogue specialists from education, political theory, literature and cultural studies with the aim to underscoring Rousseau's contributions to themes that preoccupy us today such as (...) the appreciation of slow time, the uncounted time of women's lives and temporal challenges related to politics and economy. (shrink)

In recent years, ethical questions related to the development of artificial intelligence are being increasingly discussed. However, there has not been enough corresponding increase in the research and development associated with AI technology that incorporates with ethical discussion. We therefore implemented an organic and dynamic tool for use with knowledge base of AI ethics for engineers to promote engineers’ practice of ethical AI design to realize further social values. Here, “organic” means that the tool deals with complex relationships among different (...) AI ethics. “Dynamic” means that the tool dynamically adopts new issues and helps engineers think in their own contexts. Data in the knowledge base of the tool is standardized based on the ethical design theory that consists of an extension of the hierarchical representation of artifacts to understand ethical considerations from the perspective of engineering, and a description method to express the design ideas. In addition, we apply the dynamic knowledge management model called knowledge liquidization and crystallization. To discuss the effects, we introduce three cases: a case for the clarification of differences in the structures among AI ethics and design ideas, a case for the presentation of semantic distance among them, and a case for the recommendation of the scenario paths that allow engineers to seamlessly use AI ethics in their own contexts. We discuss the effectiveness of the tool. We also show the probability that engineers can reconstruct AI ethics as a more practical one with professional ethicists. (shrink)

Rousseau a bien compris, mieux que ses contemporains peut-être, le paradoxe de la communication propre aux Lumières, prises entre le développement du savoir et la constitution d'une opinion publique. Avec l'accélération de la circulation des discours et des écrits, comment parler et agir philosophiquement sans se perdre? Comment concilier la culture du secret, issue de la tradition littéraire du libertinage érudit, et la publicité, qui ouvre de plus en plus grands les horizons de la sphère publique? Masano Yamashita examine (...) ici l'articulation entre les stratégies rhétoriques de l'adresse au lecteur chez Rousseau et sa conception proprement philosophique de la communication. Elle met en lumière l'originalité et la lucidité de Rousseau face aux difficultés liées à cette société de l'information d'Ancien Régime. Rousseau cherche les conditions de possibilité d'une parole émancipée et pleinement publique. Au moyen d'une philosophie incarnée mettant en scène une figure de lecteur, il met à l'épreuve l'idée d'un sujet universel, la constitution d'un espace public, le sens de l'exercice de la philosophie, les enjeux politiques et éthiques des actes de discours. La réception des textes et le rapport au public constituent ainsi pour Rousseau un enjeu philosophique. Entre exigence de transparence et désir d'expérimenter les diverses facettes du moi public, se dessine la conception originale que Rousseau se fait de l'homme des Lumières. Masano Yamashita montre que la réflexion de Rousseau sur les manières de vivre dans un espace public, social comme littéraire, débouche sur une véritable vie philosophique. (shrink)