How cell polarity is established and maintained is an important question in diverse biological contexts. Molecular mechanisms used to localize polarity proteins to distinct domains are likely context‐dependent and provide a feedback loop in order to maintain polarity. One such mechanism is the localized translation of mRNAs encoding polarity proteins, which will be the focus of this review and may play a more important role in the establishment and maintenance of polarity than is currently known. Localized translation of mRNAs encoding (...) polarity proteins can be used to establish polarity in response to an external signal, and to maintain polarity by local production of polarity determinants. The importance of this mechanism is illustrated by recent findings, including orb2‐dependent localized translation of aPKC mRNA at the apical end of elongating spermatid tails in the Drosophila testis, and the apical localization of stardust A mRNA in Drosophila follicle and embryonic epithelia. (shrink)

Intense or industrial animal husbandry is morally bad. This consensus in animal ethics led to the emergence of veganism which is recently in decline in favour of ‘conscientious carnivorism’ which advocates eating animal products from animal-friendly animal husbandry in response to the moral problems of industrial farming. Advocates of animal-friendly husbandry justify rearing and killing ‘happy animals’ by highlighting that the animals live pleasant lives and would not have existed if not reared for human consumption. In this paper, I tackle (...) this ‘logic of the larder’ by showing that it serves as a purification strategy to conceal the harm that animals experience in this alleged animal-friendly type of farming. Defenders of ‘happy meat’ claim that animal-friendly animal husbandry is in the animals’ best interests and that it is in effect a ‘win-win situation’ for humans and farm animals alike. Departing from two critics of animal-friendly animal husbandry, I will show that the problem of this logic is that it evades the fact that moral residuals, which is the experienced harm by the animals, remain by engaging in this practice. Even if there may be strong reasons for the consumption of meat and derivatives of ‘happy animals’, the experienced harm for the animals will not be extinguished. I will denote the detachment that derives from the strategy of rendering the animals’ experienced harm in animal-friendly animal husbandry invisible as guilt. I will conclude that instead of purifying eating animals the ‘good way’, we should face the responsibility we have when killing ‘happy animals’ for ‘happy meat’. (shrink)

Konstantin Pollok - Kant's Critical Concepts of Motion - Journal of the History of Philosophy 44:4 Journal of the History of Philosophy 44.4 559-575 Muse Search Journals This Journal Contents Kant's Critical Concepts of Motion Konstantin Pollok There are two significant places in Kant's Critical corpus where he discusses the concept of motion. The first is in the Critique of Pure Reason, where in the "Deduction of the Categories" Kant writes: Motion, as an act of the subject , (...) and therefore the synthesis of the manifold in space, first produces the concept of succession—if we abstract from this manifold and attend solely to the act through which we determine the inner sense according to its form. In this passage Kant simply refers to the concept of motion, and the immediate context in which this reference occurs reveals little about what he means by it. In the Metaphysical Foundations of Natural Science, however, motion plays a more significant role, and, concomitantly, it is in his writings on natural science that Kant most fully expresses his thoughts on the subject. For present purposes, the most relevant passage is paragraph 15 of the Preface of the Metaphysical Foundations, where Kant says that the concept of matter had … to be carried through all four of the indicated functions of the concepts of the understanding , where in each a new determination of this concept was added. The.. (shrink)

In his book, Aurelien Djian investigates the history of the concept of horizon in the evolution of Husserl’s thought. Addressing the most fundamental concerns of phenomenology, Djian redefines the horizon considering themes such as coherence of experience, the reality of the world, and motivation. He suggests an approach to exploring the horizon grounded in a detailed analysis of Thing and Space lectures. A significant conclusion of Djians’s book is that the origin of the horizon should not be attributed to Ideas (...) I, but to these lectures. This discovery is not only of historical significance, but also opens up a new perspective on relations between the world, the incompleteness of external experience, and the fluidity of attention. Djian denies Saulius Geniusas’ interpretation of “halo” and “background” as psychological opposites of the horizon, which functions in the domain of ontology. These phenomena are given as elements of experience temporarily left by attention, connected with actual ones. The consciousness of unfulfilled potentialities of experience ensures the coherence of experience, making the transition from actual to potential seamless. This paper covers Djian’s conclusions and part of his work that goes beyond the content of the book. We also try to contextualize Djian’s research and show the history of studies of the horizon in the philosophy of Edmund Husserl. (shrink)

The new world outlook paradigm of creativity correlates with the fundamental principles of metaphysics and modern natural science. The essential programs of development of science have been formed in Antiquity as the metaphysical principles. For example – principle of continuity VS principle of discreteness of matter;movement as God’s first impulse VS movement as natural attribute of matter. In the field of metaphysics were elaborated the very impotent concepts of modern science – matter, movement, force, atom, corpuscle, energy and others (M. (...) Wartofsky, J. Agassi). Nowadays philosophers and scientists discuss such metaphysical principles as so called antropic principle (S. Hawking, B. Carter); the deep expediency and harmony of physical laws (I. Rosental, Y. Linnick); the principle of synergy and self – organization of nature (I. Prigojin, H. Haken). All these principles may be united in the new metaphysical idea of informational matrix of Universe. (shrink)

The author of the monograph is a Candidate of Culturology, Associate Professor of Tyumen State University. The monograph tests approaches to the understanding of the essence of Hobbes’s and Locke’s ideas about miracles that are more flexible than a formational-evolutionist approach. The monograph presents the main characteristics of these ideas as Christian philosophical ones, shows their general Christian direction and the historiographic perspective of studying these ideas primarily in line with Christian philosophy. The monograph is intended for experts in the (...) history of philosophy, the history of ideas, theology, religious studies, historical anthropology, as well as for those interested in the problems of historical-philosophical knowledge. Автор монографии – кандидат культурологии, доцент Тюменского государственного университета. В монографии апробируются более гибкие подходы к пониманию сущности идей Гоббса и Локка о чудесах по сравнению с формационно-эволюционистским подходом. Представлены основные характеристики идей Гоббса и Локка о чудесах как христианских философских идей. Показана общехристианская направленность идей Гоббса и Локка о чудесах и историографическая перспективность изучения этих идей в первую очередь как христианских философских идей. Монография рассчитана на специалистов в области истории философии, истории идей, теологии, религиоведения, исторической антропологии, а также на всех, кто интересуется проблемами историко-философского знания. (shrink)

The original proof of the four-color theorem by Appel and Haken sparked a controversy when Tymoczko used it to argue that the justification provided by unsurveyable proofs carried out by computers cannot be a priori. It also created a lingering impression to the effect that such proofs depend heavily for their soundness on large amounts of computation-intensive custom-built software. Contra Tymoczko, we argue that the justification provided by certain computerized mathematical proofs is not fundamentally different from that provided by surveyable (...) proofs, and can be sensibly regarded as a priori. We also show that the aforementioned impression is mistaken because it fails to distinguish between proof search (the context of discovery) and proof checking (the context of justification). By using mechanized proof assistants capable of producing certificates that can be independently checked, it is possible to carry out complex proofs without the need to trust arbitrary custom-written code. We only need to trust one fixed, small, and simple piece of software: the proof checker. This is not only possible in principle, but is in fact becoming a viable methodology for performing complicated mathematical reasoning. This is evinced by a new proof of the four-color theorem that appeared in 2005, and which was developed and checked in its entirety by a mechanical proof system. (shrink)

Konstantin Pollok offers the first book-length analysis of Kant's theory of normativity that covers foundational issues in theoretical and practical philosophy as well as aesthetics. Interpreting Kant's 'critical turn' as a normative turn, he argues that Kant's theory of normativity is both original and radical: it departs from the perfectionist ideal of early modern rationalism, and arrives at an unprecedented framework of synthetic a priori principles that determine the validity of our judgments. Pollok examines the hylomorphism in Kant's theory (...) of normativity and relates Kant's idea of our reason's self-legislation to the 'natural right' tradition, revealing Kant's debt to his predecessors as well as his relevance to contemporary debates on normativity. This book will appeal to academic researchers and advanced students of Kant, early modern philosophy and intellectual history. (shrink)

Various publications claim that medical AI systems perform as well, or better, than clinical experts. However, there have been very few controlled trials and the quality of existing studies has been called into question. There is growing concern that existing studies overestimate the clinical benefits of AI systems. This has led to calls for more, and higher-quality, randomized controlled trials of medical AI systems. While this a welcome development, AI RCTs raise novel methodological challenges that have seen little discussion. We (...) discuss some of the challenges arising in the context of AI RCTs and make some suggestions for how to meet them. (shrink)

The article attempts to compare personalist aspects in the works of Vasily Zenkovsky and Vladimir Lossky. It is shown that two types of philosophical personalism (metaphysical and existentialist) in the history of Russian thought set the framework for two types of theological personalism presented respectively by Zenkovsky and Lossky. The philosophy of Lev Lopatin was the important source for the principles of Zenkovsky’s personalist vision. The relevant philosophical background on Lossky’s personalism is provided by Nikolai Berdyaev’s works. The article considers (...) the deep criticism by the French theologian Jean-Claude Larchet, who seeks to demonstrate philosophical and existentialist sources of Lossky’s theological personalism, rather than patristical ones. It is noted that the criticism addressed to Lossky’s theory may slide to challenging the very possibility of an Orthodox theological personalism as a line of thought. It is shown that Zenkovsky’s works, presenting a nonexistentialist type of personalism, do not provoke such criticism. It’s concluded that whereas Lossky’s legacy in its personalistic aspect is challenged, Zenkovsky’s personalism enables another way of conceiving “Orthodox theological personalism.”. (shrink)

This article is a commentary on ChatGPT and LLMs (Large Language Models) in general. It argues that this technology has matured to the point where calling systems such as ChatGPT “stochastic parrots” is no longer warranted. But it also argues that these systems continue to have serious limitations when it comes to reasoning. These limitations are much more severe than commonly thought. A large array of examples are given to support these claims.

In lieu of an abstract, here is a brief excerpt of the content:Journal of the History of Philosophy 44.4 (2006) 559-575 MuseSearchJournalsThis JournalContents[Access article in PDF]Kant's Critical Concepts of MotionKonstantin PollokThere are two significant places in Kant's Critical corpus where he discusses the concept of motion. The first is in the Critique of Pure Reason, where in the "Deduction of the Categories" Kant writes:Motion, as an act of the subject (not as a determination of an object†), and therefore the synthesis (...) of the manifold in space, first produces the concept of succession—if we abstract from this manifold and attend solely to the act through which we determine the inner sense according to its form.In this passage Kant simply refers to the concept of motion, and the immediate context in which this reference occurs reveals little about what he means by it. In the Metaphysical Foundations of Natural Science, however, motion plays a more significant role, and, concomitantly, it is in his writings on natural science that Kant most fully expresses his thoughts on the subject. For present purposes, the most relevant passage is paragraph 15 of the Preface of the Metaphysical Foundations, where Kant says that theconcept of matter had … to be carried through all four of the indicated functions of the concepts of the understanding (in four chapters), where in each a new determination of this concept was added. The basic determination of something that is [End Page 559] to be an object of the outer senses had to be motion, because only thereby can these senses be affected. The understanding traces back all other predicates of matter belonging to its nature to this, and natural science, therefore, is either a pure or applied doctrine of motion. The metaphysical foundations of natural science are therefore to be brought under four chapters. The first considers motion as a pure quantum in accordance with its composition, without any quality of the movable, and may be called phoronomy. The second takes into consideration motion as belonging to the quality of matter, under the name of an original moving force, and is therefore called dynamics. The third considers matter with this quality as in relation to another through its own inherent motion, and therefore appears under the name of mechanics. The fourth chapter, however, determines matter's motion or rest merely in relation to the mode of representation or modality, and thus as appearance of the outer senses, and is called phenomenology. 2The first passage from the first Critique (quoted above) reveals both that the concept of motion plays a central role in Kant's epistemology and that he distinguishes clearly between motion of the object, on the one hand, and action of the subject, on the other. The two concepts of motion are quite different—the former belonging to transcendental philosophy and geometry (to "pure science" in the Kantian sense), the latter to the metaphysical and empirical investigation of nature. By contrast, the second passage from the Metaphysical Foundations shows that the conceptual apparatus Kant developed in his transcendental philosophy is also relevant for understanding the empirical concept of motion. Since all empirical concepts are based on transcendental conditions for their possibility, this connection between elements of the Critical philosophy should come as no surprise. What remains unclear, however, is the sort of connection involved, and whether in the particular case of motion there might not be a more intimate relationship between the transcendental conditions and the empirical concept than one might at first suspect.Indeed, this is a possibility that has been entertained by a number of commentators. In his investigation of Kant's metaphysics of nature, Lothar Schäfer, for example, contends that "the original perspective on the unity of the sensibility in which nature reveals itself, and which belongs to the conception of nature, results in the original perspective on motion. Therefore, the laws of nature are laws of motion …." 3 Similarly, in her book on Kant's theory of natural science, Karen Gloy argues thatin the predicable 'motion' the connection of elements of the understanding with... (shrink)

In this paper, we tackle the widely held view that practice-oriented approaches to ethics are conservative, preserving the moral status quo, and, in particular, that they do not promote any change in our dealings with animals or formulate clear principles that help us to achieve such change. We shall challenge this view with reference to Wittgensteinian ethics. As a first step, we show that moral thought and action rest on basic moral certainties like: equals are to be treated equally and (...) unequals unequally. We then explore the relations between this insight and the notion of the difficulty of reality elaborated by Cora Diamond. Our goal is to show that a Wittgensteinian-Diamondian approach to animal ethics is not necessarily morally conservative. Indeed, it offers a profound practice-oriented approach to animal ethics that is capable of promoting change in human dealings with animals because it is compatible with radical critique. (shrink)

Synchronic norms of theory choice, a traditional concern in scientific methodology, restrict the theories one can choose in light of given information. Diachronic norms of theory change, as studied in belief revision, restrict how one should change one’s current beliefs in light of new information. Learning norms concern how best to arrive at true beliefs. In this paper, we undertake to forge some rigorous logical relations between the three topics. Concerning, we explicate inductive truth conduciveness in terms of optimally direct (...) convergence to the truth, where optimal directness is explicated in terms of reversals and cycles of opinion prior to convergence. Concerning, we explicate Ockham’s razor and related principles of choice in terms of the information topology of the empirical problem context and show that the principles are necessary for reversal or cycle optimal convergence to the truth. Concerning, we weaken the standard principles of agm belief revision theory in intuitive ways that are also necessary for reversal or cycle optimal convergence. Then we show that some of our weakened principles of change entail corresponding principles of choice, completing the triangle of relations between,, and. (shrink)

When it comes to invasive manipulation of animals on the biological level, reactions of disgust are common and often influential on people’s moral judgments. As a case in point, the Belgian Blue, a breed of hyper-enhanced cattle which will serve as a case study for the present article, has historically been met with revulsion. Traditionally, in bio- and animal ethics, this ‘yuck factor,’ has been denied any productive role in proper moral justification, since rationalism is still a dominant paradigm in (...) those disciplines. This is not surprising since rationalism offers the fulfilment of certain expectations we have of morality, like universality, intersubjective communicability, and objectivity. Increasingly, however, the preconceptions of rationalism have been brought into question, both through empirical as well as philosophical insights. In this paper, we will explore a way in which researchers who are, accordingly, critical of rationalism, and who wish to take seriously the role disgust plays in the formation of moral judgments when it comes to biological manipulation of animals, can do so without abandoning those virtues of rationalism which make it such an appealing position. We will do so by offering what we call a ‘tempered’ kind of rationalism, that is, one which conceives of rationality in the terms of Mary Midgley, not as distinct from, but as a possible function of, well-ordered emotion. (shrink)

Synchronic norms of theory choice, a traditional concern in scientific methodology, restrict the theories one can choose in light of given information. Diachronic norms of theory change, as studied in belief revision, restrict how one should change one’s current beliefs in light of new information. Learning norms concern how best to arrive at true beliefs. In this paper, we undertake to forge some rigorous logical relations between the three topics. Concerning, we explicate inductive truth conduciveness in terms of optimally direct (...) convergence to the truth, where optimal directness is explicated in terms of reversals and cycles of opinion prior to convergence. Concerning, we explicate Ockham’s razor and related principles of choice in terms of the information topology of the empirical problem context and show that the principles are necessary for reversal or cycle optimal convergence to the truth. Concerning, we weaken the standard principles of agm belief revision theory in intuitive ways that are also necessary for reversal or cycle optimal convergence. Then we show that some of our weakened principles of change entail corresponding principles of choice, completing the triangle of relations between,, and. (shrink)

У статті досліджується проблема утворення та діяльності машинно-тракторних станцій у Радянському Союзі, починаючи від появи перших машинних товариств, тракторних колон та МТС у 20-30-х рр. XX століття та закінчуючи реорганізацією їх у ремонтно-технічні станції в 1958 р. Історичний процес створення, функціонування та реорганізації МТС розглядається в процесі сільськогосподарського виробництва.

The article analyzes the main trends of the development of cross-border e-commerce, presents the position of the main characters: both supporters of «free trade» and protectionism on issues such as government regulation, as well as further development of cross-border e-commerce.

Dieser Artikel stellt Cora Diamonds Begriff des Mitgeschöpfs dar und untersucht dessen Relevanz für tierethische und tierpolitische Diskurse. Die traditionelle Tierethik hat eine rationalistische, naturalistische und reduktionistische Tendenz. Diamonds Moralphilosophie stellt dem einen praxissensitiven Ansatz gegenüber, der Emotionen und die moralische Imagination umfasst, wobei Diamond die Bedeutung des Menschseins betont. Letztere entspringt zwar einem epistemischen Anthropozentrismus, jedoch folgt aus diesem keine Mensch-Tier-Hierarchie: Diamond plädiert dafür, andere Tiere als Mitgeschöpfe, als Gefährten auf sterblichen Pfaden, zu begreifen. Dabei zeigt Diamond an ihrer (...) Interpretation von J.M. Coetzees The Lives of Animals, wie Konzepte von anderen Tieren auf das eigene Selbstverständnis rückwirken. Abschließend erörtert der Artikel den Vorwurf des Quietismus und die Schwierigkeit der politischen Umsetzbarkeit in Diamonds Philosophie. -/- [This article outlines Cora Diamond’s concept of the fellow creature and examines its relevance for animal ethics and animal politics. Diamond’s moral philosophy contrasts the rationalistic, naturalistic, and reductionistic tendency of traditional animal ethics with a practice-oriented approach that encompasses emotions and the moral imagination. Diamond emphasizes the importance of being human, which emanates from an epistemic anthropocentrism, but from which no human-animal hierarchy follows: She pleads for recognizing other animals as fellow creatures, as companions on mortal paths. In her interpretation of J.M. Coetzee’s The Lives of Animals, Diamond shows how conceptualizing other animals influences one’s own self-understanding. Finally, the article discusses the reproach of quietism and the difficulty of political feasibility in Diamond’s philosophy.]. (shrink)

Against the well-established critical rejection of rights a growing literature in the tradition of agonistic democracy asserts their emancipatory role in the struggles for social change. However, agonistic theorists, invested as they are in the idea of democratic innovation as a process of gradual ‘augmentation’ of existing rules, institutions and practices, fail to account for the ruptural capacity, and hence for the full radical potential, of rights. Using the performative approach, I develop a conception of rights claiming as a defiant (...) practice to express the ruptural dimension of certain forms of rights politics. I demonstrate how defiant rights claiming articulates immanent critique by declaring the incapacity of putative duty-bearer institutions and governments to uphold the claimed right due to structural constraints, thereby generating inevitable contradictions within the extant order and creating the necessity for an alternative one. Moreover, in order to fully capture the emancipatory potential and creative capacity of rights, this article argues for understanding certain forms of rights politics both as augmentation and rupture, taking the two to be different dimensions of the same radical democratic practice. I present the creative use of rights discourse by the Landless Workers’ Movement in Brazil and the transnational network of agrarian movements, La Via Campesina, as precisely such a combination of the practice of augmentation and defiant claims, which has led to the transformation of the right to food and land into the right to food sovereignty, demonstration of the structural embeddedness of rights violations in the existing global regime of food production and distribution, and authorisation of an alternative vision of the future. (shrink)

How is time transformed when signs appear? In the sign system of the conditioned reflex, the sign (conditioned stimulus) reverses, changes the direction of time, and overcomes its unidirectionality and irreversibility. In a sense, there is a “return” to the past in the form of the future when the sign is introduced. The sign serves as a “Time machine” of sorts. The mechanism of time transformation is possible because a mirror is embedded inside the sign, the surface of which represents (...) the psychological present time. When past experience meets that surface in the present, it may be reflected in the form of a future event. In the course of reflection, time changes its direction: if earlier time flowed from the event (the cause), it subsequently flows to other events (the purpose). Previously inaccessible past experience is now projected into the present, “comes to life” in it and is transformed into the future. In humans, unlike in animals, signs of the second order appear. Inside the signs of the second order, a mirror is built in, and the experience of the past as a subject is reflected in the future form as an object. An individual has the opportunity to consider oneself externally as an object. It goes beyond the subjective form. Thus, secondary signs once again change time direction. Due to this phenomenon, time becomes doubly reversible: first it turns around in a conditioned stimulus, and then in a secondary sign. (shrink)

By taking into account some texts published between the first and the second edition of the Critique of Pure Reason that have been neglected by most of those who have dealt with the deduction of the categories, I argue that the core of the deduction is to be identified as the ‘almost single inference from the precisely determined definition of a judgment in general’, which Kant adumbrates in the Metaphysical Foundations in order to ‘make up for the deficiency’ of the (...) A-deduction. Whereas the first step of the B-deduction is an attempt to show that the manifold of an intuition belongs to the ‘necessary unity of self-consciousness’ by means of the synthesis of the understanding, the second step has the task of showing that the very same synthesis is responsible for the spatio-temporal unity of the manifold. Thus, Kant's ‘answer to Hume’ is that no spatio-temporal objects of experience at all are merely ‘given’, independently of the conceptual activities of the understanding. Against the established view I substantiate the claim that with this ‘almost single inference’ of the second proof step the distinction between judgments of perception and judgments of experience consequently vanished from Kant's thinking. (shrink)

Our interest in unconscious motives is not only theoretical; it is also practical, moral. Unconscious motives often perform a useful function, but this may be bought at too high a price. Special therapeutic techniques may be needed to liberate a person from the grip of an unconscious motive. Such a liberation is possible because unconscious motives operate within the larger area of conscious self-control. The goal of rational behavior is to enlarge this area of self-control by greater self-knowledge. The limits (...) of self-knowledge and self-control are flexible, and it is desirable to extend them as far as possible. (shrink)

Drawing on MacIntyre's encyclopaedia-genealogy-tradition typology of the humanities, the author describes Averintsev's project as bringing together the elements of encyclopaedia and tradition. The article identifies three forms of isolationism which are evident not only in 'post-atheistic' societies but more widely, and comments on Averintev's treatment of these.

In this paper I discuss the ways in which the early Christian writer Arnobius of Sicca used rhetoric to shape religious identity inAduersus nationes. I raise questions about the reliability of his rhetorical work as a historical source for understanding conflict between Christians and pagans. The paper is intended as an addition to the growing literature in the following current areas of study: the role of local religion and identity in the Roman Empire; the presence of pagan elements in Christian (...) religious practices; the question of how to approach rhetorical works as historical evidence. (shrink)