Many sensory processing regions of the central brain undergo critical periods of experience‐dependent plasticity. During this time ethologically relevant information shapes circuit structure and function. The mechanisms that control critical period timing and duration are poorly understood, and this is of special importance for those later periods of development, which often give rise to complex cognitive functions such as social behavior. Here, we review recent findings in Drosophila, an organism that has some unique experimental advantages, and introduce novel views for (...) manipulating plasticity in the post‐embryonic brain. Critical periods in larval and young adult flies resemble classic vertebrate models with distinct onset and termination, display clear connections with complex behaviors, and provide opportunities to control the time course of plasticity. These findings may extend our knowledge about mechanisms underlying extension and reopening of critical periods, a concept that has great relevance to many human neurodevelopmental disorders. (shrink)

In this paper I aim to clarify Hegel's objection to the use of ideals in ethical thinking by examining his opposition to Kant's ideal of perpetual peace. I explain why Hegel believes that the ideal of peace amounts to nothing more than a moral condemnation that ignores the significance for international relations of appreciating the modern nation-state as an ethical achievement. I argue, however, that Kant's proposed federation can be grounded in the concrete ethical realities Hegel accepts as compelling and (...) uses this basis to sketch a defensible understanding of the obligating force of ethical ideals against Hegel's objections. (shrink)

TWO FACETS OF HEGEL’S ETHICAL PHILOSOPHY become clear on close inspection. On the one hand, Hegel attempts to take advantage of the Kantian focus on autonomy as the ground for ethical obligation and build an account of Right in terms of free self-determining agency. On the other hand, once the account is in, it looks and feels quite different from Kant’s, emphasizing social institutions and history in ways that are distinctive to Hegel. How far do these Hegelian emphases pull us (...) from Kant? Are they simply an essential corrective of the Kantian project, as some Hegelians would like to claim? Or does Hegel end up with a view that is significantly antithetical to a Kantian position? In this paper I do not intend to address such questions comprehensively. Rather, I would like to touch on such questions by exploring a particular issue that seems to me of central importance to answering them. (shrink)

A long tradition of research in WEIRD (Western, Educated, Industrialized, Rich, Democratic) countries has investigated how people weigh individual welfare versus group welfare in their moral judgments. Relatively less research has investigated the generalizability of results across non-WEIRD populations. In the current study, we ask participants across nine diverse cultures (Bali, Costa Rica, France, Guatemala, Japan, Madagascar, Mongolia, Serbia, and the USA) to make a series of moral judgments regarding both third-party sacrifice for group welfare and first-person sacrifice for group (...) welfare. In addition to finding some amount of cross-cultural variation on most of our questions, we also find two cross-culturally consistent judgments: (1) when indi- viduals are in equivalent situations, overall welfare should be maximized, and (2) harm to individuals should be taken into account, and some types of individual harm can trump overall group welfare. We end by discussing the specific pattern of variable and consistent features in the context of evolutionary theories of the evolution of morality. (shrink)

Much indirect evidence supports the hypothesis that transformations of mental images are at least in part guided by motor processes, even in the case of images of abstract objects rather than of body parts. For example, rotation may be guided by processes that also prime one to see results of a specific motor action. We directly test the hypothesis by means of a dual-task paradigm in which subjects perform the Cooper-Shepard mental rotation task while executing an unseen motor rotation in (...) a given direction and at a previously learned speed. Four results support the inference that mental rotation relies on motor processes. First, motor rotation that is compatible with mental rotation results in faster times and fewer errors in the imagery task than when the two rotations are incompatible. Second, the angle through which subjects rotate their mental images, and the angle through which they rotate a joystick handle are correlated, but only if the directions of the two rotations are compatible. Third, motor rotation modifies the classical inverted V-shaped mental rotation response time function, favoring the direction of the motor rotation; indeed, in some cases motor rotation even shifts the location of the minimum of this curve in the direction of the motor rotation. Fourth, the preceding effect is sensitive not only to the direction of the motor rotation, but also to the motor speed. A change in the speed of motor rotation can correspondingly slow down or speed up the mental rotation. (shrink)

A study of the philosophy and theology of the spiritual life that takes religious sensibility or the practice of religious life, rather simply creedal commitment, as a starting point.

Dasein and being-in-the-world -- The world -- The structure of being-in-the-world, pt. 1: Disposedness and moods -- The structure of being-in-the-world, pt. 2: Understanding and interpretation -- Everydayness and the 'one' -- Death and authenticity -- Truth and art -- Language -- Technology -- Our mortal dwelling with things.

This article surveys the difficulties in establishing determinism for classical physics within the context of several distinct foundational approaches to the discipline. It explains that such problems commonly emerge due to a deeper problem of ‘missing physics'. The Problems of Formalism Norton's Example Three Species of Classical Mechanics 3.1 Mass point physics 3.2 The physics of perfect constraints 3.3 Continuum mechanics Conclusion CiteULike Connotea Del.icio.us What's this?

Cancer viewed as a programmed, evolutionarily conserved life‐form, rather than just a random series of disease‐causing mutations, answers the rarely asked question of what the cancer cell is for, provides meaning for its otherwise mysterious suite of attributes, and encourages a different type of thinking about treatment. The broad but consistent spectrum of traits, well‐recognized in all aggressive cancers, group naturally into three categories: taxonomy (“phylogenation”), atavism (“re‐primitivization”) and robustness (“adaptive resilience”). The parsimonious explanation is not convergent evolution, but the (...) release of an highly conserved survival program, honed by the exigencies of the Pre‐Cambrian, to which the cancer cell seems better adapted; and which is recreated within, and at great cost to, its host. Central to this program is the Warburg Effect, whose malign influence permeates well beyond aerobic glycolysis to include biomass interconversion and genomic heuristics. Warburg‐type metabolism and genomic instability are targets whose therapeutic disablement is a major priority. (shrink)

In response to physicians who refuse to provide medical services that are contrary to their ethical and/or religious beliefs, it is sometimes asserted that anyone who is not willing to provide legally and professionally permitted medical services should choose another profession. This article critically examines the underlying assumption that conscientious objection is incompatible with a physician’s professional obligations (the “incompatibility thesis”). Several accounts of the professional obligations of physicians are explored: general ethical theories (consequentialism, contractarianism, and rights-based theories), internal morality (...) (essentialist and non-essentialist conceptions), reciprocal justice, social contract, and promising. It is argued that none of these accounts of a physician’s professional obligations unequivocally supports the incompatibility thesis. (shrink)

The claim that a functional kind is multiply realized is typically motivated by appeal to intuitive examples. We are seldom told explicitly what the relevant structures are, and people have often preferred to rely on general intuitions in these cases. This article deals with the problem by explaining how to understand the proper relation between structural kinds and the functions they realize. I will suggest that the structural kinds that realize a function can be properly identified by attending to the (...) context of functional explanation. *Received June 2006; revised June 2009. †To contact the author, please write to: Department of Philosophy, Seton Hall University, 400 South Orange Ave., South Orange, NJ 07079; e‐mail: mark[email protected]. (shrink)

While various items closely associated with belief, such as speech?acts of assertion, or what have recently been termed acts of ?acceptance?, can clearly be voluntary, it is commonly supposed that belief itself, being intrinsically truth?directed, is essentially passive. I argue that while this may be true of belief proper, understood as a kind of disposition, it is not true of acts of assent or ?judgment?. Judgments, I contend, must be deemed voluntary precisely because of their truth?aimedness, for in their case (...) this feature entails that they can always be regarded as the subjects of a kind of implicit practical reasoning. By emphasizing the familiar point that voluntariness need not involve anything more than this, and by invoking the soft determinist option of holding causation to be compatible with choice, I seek to deflect some anticipated objections to this argument. (shrink)

Research ethics regulation in parts of the Global North has sometimes been initiated in the face of biomedical scandal. More recently, developing and recently developed countries have had additional reasons to regulate, doing so to attract international clinical trials and American research funding, publish in international journals, or to respond to broader social changes. In Taiwan, biomedical research ethics policy based on ‘principlism’ and committee- based review were imported from the United States. Professionalisation of research ethics displaced other longer-standing ways (...) of conceiving ethics connected with Taiwanese cultural traditions. Subsequently, the model and its discursive practices were extended to other disciplines. Regulation was also shaped by decolonizing dis- courses associated with asserting Indigenous peoples’ rights. Locating research ethics regulation within the language and practices of public policy formation and transfer as well as decolonization, allows analysis to move be- yond the self-referential and attend to the social, economic and political context within which regulation operates. 研究倫理規範甚至法制化的濫觴,過去在有些北美國家是為了回應其國內發生的醫學研究倫 理醜聞。但近年來,無論是發展中或已開發國家,往往是為了爭取國際醫學臨床試驗計畫能在 其國內執行、爭取美國相關研究經費、能在英語的國際期刊發表文章、或是因應國內相關社會變化。 以台灣來說,基於「原則主義」的醫學領域之研究倫理政策及規範,以及在研究機構內成立 委員會專責倫理審查的運作模式,可說完全移植自美國。這種運作模式及研究倫理的專業化, 不但逐漸取代過去已融合台灣文化的研究倫理觀쳀,且在這種運作模式下的倫理論述及實作, 更從醫學領域擴展至其他研究領域。在此同時,台灣的研究倫理規範之發展,也受到台灣原住 民族的去殖民化及群體權主張等影響。. (shrink)

This is a clear and critical account of Foucault's political thought: what he said, how it's been used and its influence today. Michel Foucault, French philosopher, social theorist, historian of ideas and literary critic, is primarily known as a radical thinker who disturbs our understanding of society, yet little attention has been paid to his politics. Now, Mark Kelly details and criticises all of Foucault's major political ideas: the historical relativity of knowledge; exclusion and abnormality; his radical reconception of (...) power; his historical analysis of biopolitics in terms of discipline and biopower; his concept of governmentality; and his late work around ethics and subjectivity. Kelly shows how Foucault's positions changed over time, how his thought has been used in the political sphere and examines the importance of his work for politics today. It engages with Foucault's entire corpus, from his first works right up to his posthumously published College de France lectures and the unabridged version of the History of Madness. It looks at the theoretical reception of Foucault's thought and how it has been applied to real-world problems. (shrink)

A step-by-step guide to Foucault's History of Sexuality Volume I, The Will to KnowledgeIn the first volume of his History of Sexuality, The Will to Knowledge, Foucault weaves together the most influential theoretical account of sexuality since Freud. Mark Kelly systematically unpacks the intricacies of Foucault's dense and sometimes confusing exposition, in a straightforward way, putting it in its historical and theoretical context.This is both a guide for the reader new to the text and one that offers new insights (...) to those already familiar with Foucault's work. (shrink)

It has been some years since Locke Studies published an update on the Clarendon Edition. The current state of the Edition is given here. Two volumes will appear within the next eighteen months: J. R. Milton’s edition of the Abridgements of the Essay and Mark Goldie’s edition of The Correspondence of John Locke, vol. 9, Supplement.

The essays in this volume reflect this desire to "make a difference"—not just in the world of academic philosophy, but in the broader world.

This is one of those cases to which Dr. 8 oodhouse's remark applies with all its force, that a method which leads to true results must have its logic — H.S Smith (" On Some of the Methods at Present in Use in Pure Geometry," p. 6) A goodly amount of modern metaphysics has concerned itself, in one form or another, with the question: what attitude should we take in regard to a language whose semantic underpinnings seem less than certain? (...) Since much of standard English is surely of this type, many philosophers have felt driven to extreme and unpalatable resolutions — wholesale rejection of attractive logical rules, radical "antirealism", "minimalism" about truth, and so forth, Scientists, however, have long dealt with analogous foundational insecurities and, under the duress of practicality, have framed a set of shifting attitudes towards language and reasoning that seem far more commonsensical than the extreme positions to which pure philosophy has often been led. Following this lead, this essay will recommend a more nuanced approach to linguistic insecurity that is neither naively optimistic nor mired in the gloomy sloughs of antirealism. (shrink)

Physicists often allow the "laws" of a discipline, formulated as partial differential equations, to be disobeyed along various surfaces, arrayed along the boundary and inside the medium under study. What kinds of considerations permit these lapses in the applicability of the equations? This paper surveys a variety of answers found in the physical literature.

There are many radically different ways of understanding the distinction between linked and convergent arguments. This paper provides a generic model which enables one to articulate in a rigorous manner the important differences as well as the underlying similarities that exist between competing proposals. In addition, the paper offers a TRUE (Type Reduction Upon Elimination) test for distinguishing linked from convergent arguments which best captures the informal intuition that linked arguments are especially vulnerable to local criticisms pertaining to premise acceptability.

Many feminist epistemologists have been inclined to embrace socialized epistemology. There are, however, many different theses that go by that name. Sandra Harding, Lynn Hankinson Nelson, and Elizabeth Potter hold various of these theses, but their reasons for holding those theses, while they do support less ambitious theses, do not support the theses they are offered to support.

This survey article describes Frege's celebrated foundational work against the context of other late nineteenth century approaches to introducing mathematically novel "extension elements" within both algebra and geometry.

Suppose that two nations A and B each possess a nuclear arsenal and are rational utility-maximizers. Suppose further that B has some interest in provoking A, possibly by attacking her with nuclear weapons. In the hope of preventing this from happening, A informs B of à conditional intention on her part to retaliate against B with nuclear weapons should B in fact attack A. By doing so A attempts to lower the probability of B's attacking A by increasing B's estimate (...) of the conditional probability of A's retaliating once provoked. Problematic deterrent situations are those in which B prefers to attack A without retaliation, A prefers most of all that she not be attacked, and A prefers an attack-with-no-retaliation scenario to an attack-with-retaliation scenario. Feature is à result of the fact that A prefers to minimize nuclear devastation, i.e., A would herself be worse off retaliating than not retaliating to an attack. Now, if B knows all of this to be the case then A's expression of a conditional intention to retaliate will not in fact deter B from attacking, since A is rational and will not act contrary to her own best interests. B has no reason to fear A's retaliation and therefore B has no reason not to attack. Deterrence, it seems, is an irrational policy among fully rational actors. This is one version of the so-called paradox of deter-rence. If expressing a conditional retaliatory intention is the best way for A to ward off an attack, then the paradox can be strengthened as follows: It is rational for A to intend to act irrationally. (shrink)

The cladistic species concept proposed by Ridley (1989) rests on an undefined notion of speciation and its meaning is thus indeterminate. If the cladistic concept is made determinate through the definition of speciation, then it reduces to a form of whatever species concept is implicit in the definition of speciation and fails to be a truly alternative species concept. The cladistic formalism advocated by Ridley is designed to ensure that species are monophyletic, that they are objectively real entities, and that (...) they are individuals. It is argued that species need not be monophyletic in order to be real entities, and that ancestor-descendant relations are not the only relations that confer individuality on entities. The species problem is recast in terms of a futile quest for a definition of that single kind of entity to which the term species should uniquely apply. (shrink)

What is the nature of rational disagreement? A number of philosophers have recently addressed this question by examining how we should respond to epistemic conflict with a so-called epistemic peer—that is, someone over whom you enjoy no epistemic advantage. Some say that you're rationally required to suspend judgment in these cases—thereby denying the very possibility of a certain kind of rational disagreement. Others say that it's permissible to retain your beliefs even in the face of epistemic conflict. By distinguishing between (...) close peers and distant peers, I argue that it's rational to respond to different types of peers in different ways. I also argue that remote peers—a particularly distant kind of distant peer—provide us with an important lesson in epistemic humility. (shrink)

A debate has simmered concerning the nature of clinical reasoning, especially diagnostic reasoning: Is it a “science” or an “art”? The trend since the seventeenth century has been to regard medical reasoning as scientific reasoning, and the most advanced clinical reasoning is the most scientific. However, in recent years, several scholars have argued that clinical reasoning is clearly not “science” reasoning, but is in fact a species of narratival or hermeneutical reasoning. The study reviews this dispute, and argues that in (...) a theoretical sense, the dispute rests upon a naïve—but very popular—caricature of what constitutes “science reasoning.” But, if the dispute rests upon just such a caricature, why is it so persistent? The study concludes by suggesting that we, as patients and as physicians, have deep psychological tendencies that incline us to adopt the very naïve “science” concept/model of diagnostic reasoning, even if (or when) we understand its inaptness. (shrink)

There is considerable likelihood that Gottlob Frege began writing his Foundations of Arithmetic with the expectation that he could introduce his numbers, not with sets, but through some algebraic techniques borrowed from earlier writers of the Gottingen school. These rewriting techniques, had they worked, would have required strong philosophical justification provided by Frege's celebrated "context principle," which otherwise serves little evident purpose in the published Foundations.

Questions of how we claim to know the things that we know and whose claims to knowledge are treated as authoritative are inescapable in reaching legal judgments. I want to illustrate this generalization by referring to a pair of hypothetical self-defense cases that, I argue, require fact finders to judge both how “accurately” each defendant understood the situation in which he found himself and how accurately policymakers can assess the consequences of alternative legal rules.The first case I will deal with (...) is one in which the defendant shoots and kills her sleeping husband. The husband had physically abused her over a long period. While the defendant will of course acknowledge that she was in no immediate danger at the moment she killed the man, her preliminary claim is that she needed to act self-defensively at that moment for fear that she subsequently would be incapable of defending herself against life-threatening attacks that she was convinced would inevitably be made.The second case is one in which a white defendant shoots and kills a black teenager who has confronted him on the subway, in a situation in which the teenager’s “threats” were ambiguous. The shooting victim had brandished no weapon and made no physical contact with the defendant, but he had “asked” the defendant for money and, in the defendant’s mind, displayed a generally threatening demeanor. I will presuppose that this defendant—unlike Bernhard Goetz, the defendant in the notorious New York subway vigilante case on which I partly base this hypothetical model—overtly acknowledges that the race of the victim played a substantial role in his assessment of the danger of the situation. Mark Kelman, professor of law at Stanford University, is the author of A Guide to Critical Legal Studies as well as a number of articles on law and economics, taxation, criminal law, and legal theory. (shrink)

This study offers a theoretical framework for stakeholder management in an international and multicultural environment. Through the use of an extensive qualitative case study analysis, a methodological approach was developed for analyzing stakeholder dialogue data for cultural differences. Based on the empirical data it was possible to show specific ways in which cultural dimensions affect the international diffusion of stakeholder related policies. These findings contribute to the fields knowledge on internal stakeholder management implementation, by addressing the complexity of embedding stakeholder (...) management principles and practices within various international subsidiaries of the same multinational organization. (shrink)

In this paper, I delineate one tradition of contemporary political thought that has emerged within the more general climate of difference and diversity. This is ‘agonistic pluralism’. The paper evaluates the recent work of three authors, who exemplify this strand of political thinking; William Connolly, Chantal Mouffe, and James Tully. Over the past decade, each of these three has developed the notion of agonistic pluralism. The task here is to examine points of comparison between them. I compare the three authors' (...) conceptions of politics and of the dimension of the political. I make the case that their work complements one another, they each endorse broad notions of the political; and they understand politics to be constitutive of social relations. Nevertheless, the forms of politics that they describe differ from one another. It is my contention that these forms of politics are interdependent and mutually reinforcing. However, I maintain that in order for their work to be understood in this way, the political practices described by Connolly and Tully — struggles for self-making and for recognition respectively — must be re-figured as forms of sub-constitutional politics. These forms of politics will make up necessary elements of a viable pluralist society, but they are played out within multiple public spheres made possible by — what we might call — the quasi-republican political constitution elaborated by Mouffe. (shrink)

In this paper I hope to demonstrate that, despite dramatic differences in approach, Analytic and Continental philosophers can be brought into a productive dialogue with one another on topics central to the philosophical agenda of both traditions. Their differences tend to obscure the fact that both traditions have as a fundamental project the critique of past accounts of language, intentionality, and mind. Moreover, writers within the two traditions are frequently in considerable agreement about the failings of past accounts. Where they (...) tend to differ is in the sorts of positive accounts they give. By exploring the important areas of disagreement against the background of agreement, however, it is possible to gain insights unavailable to those rooted in a single tradition. (shrink)

Kenney, Mark Review(s) of: A source critical edition of the gospels of Matthew and Luke in Greek and English, 2 vols., Christopher J. Monaghan, C.P., Rome: Gregorian and Biblical Press, 2010, pp.378, 45.00.

R J W Evans: Political Chronology; IntroductionJan Rychlík: Czech-Slovak Relations in Czechoslovakia, 1918-39Eagle Glassheim: Ambivalent Capitalists: The Roots of Fascist Ideology among Bohemian Nobles, 1880-1938Melissa Feinberg: The New 'Woman Question': Gender, Nation, and Citizenship in the First Czechoslovak RepublicRobert B. Pynsent: The Literary Representation of the Czechoslovak 'Legions' in RussiaCatherine Albrecht: Economic Nationalism in the Sudetenland, 1918-38R.J.W. Evans: Hungarians, Czechs and Slovaks: Some Mutual Perceptions, 1900-50Mark Cornwall: 'A Leap into Ice-Cold Water': the Manoeuvres of the Henlein Movement in Czechoslovakia, 1933-8Vít (...) Smetana: Old Wine in New Bottles? British Policy towards Czechoslovakia, 1938-9 and 1947-8Tatjana Tönsmeyer: The German Advisers in Slovakia, 1939-45: Conflict or Co-Operation?Mark Dimond: The Sokol and Czech Nationalism, 1918-48Jiri Kocian: The Czechs versus the Slovaks: Bilateral Relations, 1944-8Zdenk Radvanovský: The Transfer of Czechoslovakia's Germans and its Impact in the Border Region after the Second World WarKeith Robbins: Britain and Munich Reconsidered: A Personal Historical Journey. (shrink)

Augustine′s conversion to Christianity in A.D. 386 is a pivotal moment not only in his own life, but in Christian and world history, for the theology of Augustine set the course of theological and cultural development in the western Christian church. But to what exactly was Augustine converted? Scholars have long debated whether he really converted to Christianity in 386, whether he was a Platonist, and, if he adhered to both Platonism and Christianity, which dominated his thought. The debate of (...) the last thirteen decades spans an immense body of literature in multiple languages. In this literature, four major views on Augustine′s conversion may be discerned. The first view is associated with Gaston Boissier and Adolph von Harnack, and was famously championed by Prosper Alfaric: that Augustine in 386 converted to neo-Platonism but not to Christianity. Second, there is the view recently promoted by Catherine Conybeare: that Augustine in 386 converted to Christianity and rejected neo-Platonism. Third, there is the view that he converted to Christianity and was also a neo-Platonist; the most famous adherents of this view are Robert J. O′Connell and Pierre Courcelle. Finally, there is the view recently promoted by Carol Harrison: that Augustine committed to Christianity in 386, yet did not utterly reject neo-Platonism; rather, he aimed to develop a Christian faith that was informed by neo-Platonic insight. In this article, I first explain and distinguish these four general views, and then I explain why I prefer the fourth view. -/- More Info: This is the pre-peer reviewed version of Boone, Mark, "The Role of Platonism in Augustine's 386 Conversion to Christianity," Religion Compass 9.5 (May 2015), 151-61. This article has been published in final form at http://onlinelibrary.wiley.com/doi/10.1111/rec3.12149/abstract. (shrink)