Loop regions in proteins have traditionally been described as ‘random coil’, although they are known to adopt well‐defined conformations in most globular proteins. In this contribution we summarize the results of detailed analysis of the structures and sequences of these loop regions in proteins of known three‐dimensional structure. We also describe how these results can be used as an aid to protein design, modification and modelling.

The primary objective of this study is to provide a description of the major ideas about void space within and beyond the world that were formulated between the fourteenth and early eighteenth centuries. The second part of the book - on infinite, extracosmic void space - is of special significance. The significance of Professor Grant's account is twofold: it provides the first comprehensive and detailed description of the scholastic Aristotelian arguments for and against the existence of void space; and it (...) presents (again for the first time) an analysis of the possible influence of scholastic ideas and arguments on the interpretations of space proposed by the nonscholastic authors who made the Scientific Revolution possible. The concluding chapter of the book is unique in not only describing the conceptualizations of space proposed by the makers of the Scientific Revolution, but in assessing the role of readily available scholastic ideas on the conception of space adopted for the Newtonian world. (shrink)

Instead of investigating the interference between two stationary, rectilinear wave functions in a trajectory representation by examining the trajectories of the two rectilinear wave functions individually, we examine a dichromatic wave function that is synthesized from the two interfering wave functions. The physics of interference is contained in the reduced action for the dichromatic wave function. As this reduced action is a generator of the motion for the dichromatic wave function, it determines the dichromatic wave function’s trajectory. The quantum effective (...) mass renders insight into the behavior of the trajectory. The trajectory in turn renders insight into quantum nonlocality. (shrink)

Psychology without genuinely thoughtful philosophy winds up as self-help gimmicks; philosophy without the insights & feeling of psychology remains an arcane academic game out of touch with life. By re-joining spirit & soul, this book is a major work of both philosophy & psychology. Casey asks puzzling questions & gives lasting answers. In a clear & vivid manner, one of America's best professional thinkers takes up one of the great themes of imagination, fantasy, hallucination, remembering & perceiving. Film & architecture (...) provide surprising material for his brilliant & useful account of basic philosophical problems which are also major mysteries of the soul. (shrink)

The so-called ergodic hierarchy (EH) is a central part of ergodic theory. It is a hierarchy of properties that dynamical systems can possess. Its five levels are egrodicity, weak mixing, strong mixing, Kolomogorov, and Bernoulli. Although EH is a mathematical theory, its concepts have been widely used in the foundations of statistical physics, accounts of randomness, and discussions about the nature of chaos. We introduce EH and discuss its applications in these fields.

In this unique study of the process of filmmaking, director Edward Dmytryk blends abstract film theory and the practical realities of feature film production to provide an artful and elegant analysis of the conceptual foundations of filmmaking and film studies. Dmytryk explores the technical principles underlying the craft of filmmaking and how their use is effective in developing the viewer's involvement in the cinematic narrative. Originally published in 1988, this reissue of Dmytryk's classic book includes a new critical introduction (...) by Joe McElhaney. (shrink)

Generalizations of the virial theorem are derived: In atomic physics, in systems including electromagnetic radiation, in Newtonian gravitation, and in general relativity and also some types of nuclear forces. The cases discussed are limited to potentials which can be produced by the exchange of one particle, which include potentials of the form1/r. The method used is to set equal a change in energy produced by an infinitesimal similarity transformation to a change of energy obtained by a first-order perturbation.

Kuhlman exposes the dangers of excessive reliance on technical efficiency and avoidance of pain in the individual struggle to become educated and calls for renewed recognition of the importance of effort and agony in human accomplishment.

Hobbes' philosophy is one of the high points of a century of great philosophical achievement and Leviathan is recognized as one of the great classics of political theory. But the response from Hobbes's contemporaries to his secular analysis of society demonstrated the challenging nature of his ideas. This collection of many of the major contemporary responses to his thought by leading figures, mostly never republished, provides an outstanding source for assessing his immediate impact and the long-term importance of his work.

Transcript of lectures delivered at the Indian Institute of Advanced Study, 1996.

The Washington National Cathedral, set on the highest hill in the capital city of the world's greatest economic and military power, is an iconic location for an examination of the intersection of immaterial faith, material power, and human conscious experience. It is a location made even more symbolic due to the fact that surrounding the Cathedral on three sides are three private schools -- an elementary school (Beauvoir) to the east, a boys' school (St. Albans) to the south, and a (...) girls' school (National Cathedral School) to the north. The students at these private schools include children of persons who wield the secular power headquartered in the City below the Cathedral Tower. Every day these students study and compete upon a hill giving them panoramic views over the great monuments and symbols of American power: the Capitol Dome, the Washington Monument, the entire City. And the Cathedral that marks their spot upon this globe is visible from all over the region, high above the City. These students are intelligent and informed, and thus for purposes of a dramatic-oriented form of exploration of interesting issues, provide a persuasive characterization for participants in a dialog of two iconic children, older teenagers, a boy and a girl, students at these schools and worshippers in the Cathedral, to develop an examination of themes of faith, power, and the experience of sentience in the material world, walking within and around the Washington National Cathedral, two of its affiliated schools, and the gardens and forests surrounding. The approach recalls the form of the dialogs of Plato, in which persons of elite educational and cultural status encounter each other within a specific building or location, and proceed to discuss such matters as are provoked to mind by the encounter of those minds in that place. The major character of the piece, Merian Validus, is, among other things, a bell-ringer of the Cathedral, a denizen of its highest tower -- as are in reality a group of the girls of NCS. She is an Esmeralda performing the role of Quasimodo. After reading this, think of that the next time you land at Reagan National Airport and catch your cab, looking right at the Cathedral as you speed north into the City. (shrink)

In this entry, Frege’s logic is introduced and described in some detail. It is shown how the Dedekind-Peano axioms for number theory can be derived from a consistent fragment of Frege’s logic, with Hume’s Principle replacing Basic Law V.

COUNTERREVOLUTIONARY RESPONSES to the twentieth-century revolution in logic have usually started from the assumption that there is in fact a body of theory for which the name 'extensional logic' is appropriate. Debate has centered not on that assumption but rather on such questions as whether that logic includes every important feature that belongs in a proper logic and whether it excludes all features that should be excluded from that ordered realm. Revisionist logicians have usually supposed that extensional logic, for all (...) its power and versatility, does not express the tight bond between meanings that is of the very essence of the logical connection; and they have labored to provide an alternative intensional logic that does indeed express it. (shrink)

In this essay I will assume that all well-developed discussions of the authenticity of responsibility are metaphysical ones. But as I intend to make use of the notion of being at a number of crucial points, I will call responsibility ontic responsibility rather than metaphysical responsibility. If ontic responsibility should be authentic, both social responsibility and its most important particular instance, legal responsibility, will be qualified by it, and we shall not be able to capture their full meaning in terms (...) of de facto accountability. As for moral responsibility, its status will also depend upon whether or not ontic responsibility is authentic. Indeed, many readers might prefer to say that "ontic responsibility" is simply another name for moral responsibility--that the question whether we are so constituted in our ontological natures as to make accountability appropriate, just, and seemly is merely the question whether moral responsibility is authentic. But there are some grounds for thinking that ontic responsibility is a wider category and that, if it is authentic, moral responsibility is a special case of it--ontic responsibility exercised in certain well-defined and very important circumstances. It is clear, for instance, that ontic responsibility covers all acts whatsoever, or at least all acts that admit of degree of excellence, so that all our work in science, in the arts, and indeed in the entire practical-productive sphere comes under it. Thus, all Max Planck's work in science from his 1879 doctoral dissertation to his famous 1900 paper would exemplify it. But most of us would probably say that only some of the ontically responsible acts performed in the course of his scientific work were also instances of moral responsibility--perhaps only those which involved relations with other persons. At any rate, in this essay I will assume that, if ontic responsibility is authentic, moral responsibility is a special case of it. It will be clear, then, that we want the notion of ontic responsibility to function in many of the ways in which the notion of free will functions in other settings. We shall see that there is some advantage in thus avoiding that vexed notion in what follows. (shrink)

THERE would appear to be no philosophical consensus about the nature of human action, even though discussion of that ancient topic has intensified in the last two decades. I shall nevertheless ask the reader to suppose that the question has at last been settled in its main lines, and settled in a way I shall describe in a moment. The supposition I have in mind is no light matter. The universe it envisions is radically different from what it would be (...) if some other supposition were in its place. A detailed justification of it would require a thoroughgoing reassessment of many of the notions about causality that have prevailed in this century. Though I have offered something of that kind in earlier writings, the most I can hope to do here is to state the supposition in as brief, vivid, and concrete a way as I can manage. After that I shall ask what view of the rational agent it leads us to. No matter how action itself is interpreted, common sense attributes action to an agent. If the actions are those that take place in an atmosphere of rational discourse, it is natural to think of the agent as a rational one. Do we have any right to make this attribution in any way more exacting than that of common sense? Precisely what ontological status does the rational agent have? What, in particular, are we to make of its self-identity, seeing that some actions seem to modify the self-identity in which in a prima facie sense they originate? (shrink)

To begin with, there is a conceptual necessity implied in the very concept of cause itself, and in all concepts that have a causal element; and this definitional "must," far from being conventional or arbitrary, reflects the natural necessity of those physical systems which in fact constitute the nature of our universe. The conceptual necessity of the concept of cause can be pointed up in the following way. Assume that we have good reason for saying at to that f, g, (...) h, and i are jointly sufficient to E and hence C of E. What would we say at t1 if f, g, h, and i occurred but not E? We would clearly not say then, or ever, that while ordinarily these conditions are jointly sufficient for E, this time they were not; rather we would say that somehow we were mistaken in thinking that f, g, h, and i at t1 were identical with f, g, h, and i at t0. We might have been mistaken in either of two ways. We might have mis-identified one of the conditions at t1, erroneously thinking, say, that p was an f; or one or more of the conditions might have had its nature altered, losing some capacity or power it once had. In either case, we would withdraw the claim at t1 that C was the cause of E. Since we would withdraw the use of C at t1 and would never admit that f, g, h, and i at any t, if genuine instances of f, g, h, and i, would not produce E, we are clearly using C in such a way that actually producing E is part of its meaning. On the assumption that the conditions are genuinely the same, it follows, so to speak, from the principle of identity that they must produce the same effect. (shrink)

Ethics, Love, and Faith in Kierkegaard collects essays from 13 leading scholars that center on key themes that characterize Kierkegaard's philosophy of religion. With their unique focus on notions of the self, views on the command to love one's neighbor, thoughts on melancholy and despair, and the articulation of religious vision, the essays in this volume cover the breadth and depth of Kierkegaard's philosophical and religious writings. Poised at the intersection of Kierkegaard's moral psychology and its religious significance, they offer (...) vivid testimony to the ongoing power of his unique and fervent religious spirit. Students and scholars alike will find new light shed on questions that define Kierkegaard's philosophy and religion today. (shrink)

In this paper, the author considers an argument against the thesis that humans are irrational in the sense that we reason according to principles that differ from those we ought to follow. The argument begins by noting that if humans are irrational, we should not trust the results of our reasoning processes. If we are justified in believing that humans are irrational, then, since this belief results from a reasoning process, we should not accept this belief. The claim that humans (...) are irrational is, thus, self-undermining. The author shows that this argument---and others like it---fails for several interesting reasons. In fact, there is nothing self-undermining about the claim that humans are irrational; empirical research to establish this claim does not face the sorts of a priori problems that some philosophers and psychologists have claimed it does. (shrink)