Legal frameworks are in place to protect those who lack the capacity to consent to research, such as the Mental Capacity Act in the UK. Assent is sought instead from a proxy, usually a relative. However, the same legislation may, perversely, affect the welfare of those who lack capacity and of others by hindering the process of recruitment into otherwise potentially beneficial research. In addition, the onus of responsibility is moved from those who know most about the study (ie, the (...) scientific community) to those who know less (the proxies). In this paper, we describe the characteristics of a sample at different stages of the recruitment process of an influenza vaccine-based randomised control trial in elderly care home residents (the FEVER study). 62% (602/968) of potential subjects lacked capacity but only 29% (80/277) of those actually randomised. Older age, being female and living in an Elderly Mentally Ill care home were the only variables associated with lacking capacity. Considering this was a study based in a care home setting where the prevalence of dementia approximates 80%, the trial, like many others, was thus significantly biased. We believe that difficulties seeking proxy assent contributed significantly to this problem. Further thought should be given to how assent to enter research for those who lack capacity should be provided, and we suggest avenues for further discussion such as independent risk/benefit expert panels. (shrink)

This chapter concentrates mainly on biomedical cognitive enhancements, but many of the remarks apply equally to enhancements that work on non‐cognitive capacities, and to non‐biomedical means of enhancement. Proponents of a positive right to enhancements could argue their case on grounds of fairness or equality, or on grounds of a public interest in the promotion of the capacities required for autonomous agency. The societal benefits of effective cognitive enhancement may turn out to be so large and unequivocal that it would (...) be economically efficient to subsidize enhancement for the poor, just as the state now subsidizes education. The example on iodine deficiency illustrates that cognitive enhancement policy need not center on preparing the ground for sophisticated, yet‐to‐be‐realized technologies. “Smart policy” should, rather, take as its starting point the recognition that effective cognition is not only subjectively valuable to individuals, but also delivers significant social, cultural, financial, and scientific benefits. (shrink)

As a result of the world-wide COVID-19 epidemic, an internal tension in the goals of medicine has come to the forefront of public debate. Medical professionals are continuously faced with a tug of...

Evolutionary anthropology has traditionally focused on the study of small-scale, largely self-sufficient societies. The increasing rarity of these societies underscores the importance of such research yet also suggests the need to understand the processes by which such societies are being lost—what we call “modernization”—and the effects of these processes on human behavior and biology. In this article, we discuss recent efforts by evolutionary anthropologists to incorporate modernization into their research and the challenges and rewards that follow. Advantages include that these (...) studies allow for explicit testing of hypotheses that explore how behavior and biology change in conjunction with changes in social, economic, and ecological factors. In addition, modernization often provides a source of “natural experiments” since it may proceed in a piecemeal fashion through a population. Challenges arise, however, in association with reduced variability in fitness proxies such as fertility, and with the increasing use of relatively novel methodologies in evolutionary anthropology, such as the analysis of secondary data. Confronting these challenges will require careful consideration but will lead to an improved understanding of humanity. We conclude that the study of modernization offers the prospect of developing a richer evolutionary anthropology, by encompassing ultimate and proximate explanations for behavior expressed across the full range of human societies. (shrink)

What accounts for the continued lack of clarity over the legal procedures for the patenting of DNA sequences? The patenting system was built for a "bricks-and-mortar" world rather than an information economy. The fact that genes are both material molecules and informational systems helps explain the difficulty that the patent system is going to continue to have.

When We Collide is a landmark reassessment of the significance of sex in contemporary Jewish ethics. Rebecca Epstein-Levi offers a fresh and vital exploration of sexual ethics and virtue ethics in conversation with rabbinic texts and feminist and queer theory. Epstein-Levi explores how sex is not a special or particular form of social interaction but one that is entangled with all other forms of social interaction. The activities of sex-doing it, talking about it, thinking about it, regulating it-are sites (...) of ongoing moral formation on individual, interpersonal, and communal levels. When We Collide explores the development of Jewish sexual ethics, and represents an opportunity to move beyond the usual heteronormative accounts that are presented as though they were neutral representations of what "Judaism teaches about sex.". (shrink)

The claim that we have a moral obligation, where a choice can be made, to bring to birth the 'best' child possible, has been highly controversial for a number of decades. More recently Savulescu has labelled this claim the Principle of Procreative Beneficence. It has been argued that this Principle is problematic in both its reasoning and its implications, most notably in that it places lower moral value on the disabled. Relentless criticism of this proposed moral obligation, however, has been (...) unable, thus far, to discredit this Principle convincingly and as a result its influence shows no sign of abating. I will argue that while criticisms of the implications and detail of the reasoning behind it are well founded, they are unlikely to produce an argument that will ultimately discredit the obligation that the Principle of Procreative Beneficence represents. I believe that what is needed finally and convincingly to reveal the fallacy of this Principle is a critique of its ultimate theoretical foundation, the notion of impersonal harm. In this paper I argue that while the notion of impersonal harm is intuitively very appealing, its plausibility is based entirely on this intuitive appeal and not on sound moral reasoning. I show that there is another plausible explanation for our intuitive response and I believe that this, in conjunction with the other theoretical criticisms that I and others have levelled at this Principle, shows that the Principle of Procreative Beneficence should be rejected. (shrink)

Phosphatidylinositol‐3‐kinases (PI3Ks) are lipid kinases that produce 3‐phosphorylated derivatives of phosphatidylinositol upon activation by various cues. These 3‐phosphorylated lipids bind to various protein effectors to control many cellular functions. Lipid phosphatases such as phosphatase and tensin homolog (PTEN) terminate PI3K‐derived signals and are critical to ensure appropriate signaling outcomes. Many lines of evidence indicate that PI3Ks and PTEN, as well as some specific lipid effectors are highly compartmentalized, either in plasma membrane nanodomains or in endosomal compartments. We examine the evidence (...) for specific recruitment of PI3Ks, PTEN, and other related enzymes to membrane nanodomains and endocytic compartments. We then examine the hypothesis that scaffolding of the sources (PI3Ks), terminators (PTEN), and effectors of these lipid signals with a common plasma membrane nanodomain may achieve highly localized lipid signaling and ensure selective activation of specific effectors. This highlights the importance of spatial regulation of PI3K signaling in various physiological and disease contexts. (shrink)

The Principle of Procreative Beneficence claims that we have a moral obligation, where choice is possible, to choose to create the best child we can. The existence of this moral obligation has been proposed by John Harris and Julian Savulescu and has proved controversial on many levels, not least that it is eugenics, asking us to produce the best children we can, not for the sake of that child's welfare, but in order to make a better society. These are strong (...) claims that require robust justification that can be open to scrutiny and debate. This article argues that robust justifications are currently lacking in the work of Savulescu and Harris. The justifications provided for their conclusions about this obligation to have the best child possible rely heavily on Derek Parfit's Non-Identity Problem and the intuitive response this provokes in many of us. Unfortunately Harris and Savulescu do not embrace the entirety of the Non-Identity Problem and the puzzle that it presents. The Non-Identity Problem actually provides a refutation of PPB. In order to establish PPB as a credible and defendable principle, Harris and Savulescu need to find what has eluded Parfit and many others: a solution to the Non-Identity Problem and thus an overturning of the refutation it provides for PPB. While Harris and Savulescu do hint at possible but highly problematic solutions to the Non-Identity Problem, these are not developed or defended. As a result their controversial is left supported by little more than intuition. (shrink)

Advances in DNA sequencing technology open new possibilities for public health genomics, especially in the form of general population preventive genomic sequencing. Such screening programs would sit at the intersection of public health and preventive health care, and thereby at once invite and resist the use of clinical ethics and public health ethics frameworks. Despite their differences, these ethics frameworks traditionally share a central concern for individual rights. We examine two putative individual rights—the right not to know, and the child’s (...) right to an open future—frequently invoked in discussions of predictive genetic testing, in order to explore their potential contribution to evaluating this new practice. Ultimately, we conclude that traditional clinical and public health ethics frameworks, and these two rights in particular, should be complemented by a social justice perspective in order adequately to characterize the ethical dimensions of general population PGS programs. (shrink)

In Games: Agency as Art, Thi Nguyen has given us a deep and compelling picture of agency as much more layered, volatile, environment-dependent and discontinuous than it appears in most philosophical accounts. Games ‘inscribe … forms of agency into artifactual vessels’.1 1 When we play a game, we take up a form of agency, including a set of motivations, values and goals, which has been artificially provided by the game. Our purpose in playing, in the kinds of gameplay that interest (...) Nguyen, is to have the aesthetic experience of first-personally exercising the kind of agency sculpted by the game. As we move in and out of gameplay, we take up and drop values, motives, and goals that are provided to us by the game. Games can expand our autonomy and the richness of life by allowing us to practice different forms of agency, taking on different ends for the aesthetic experience of striving to meet them. While I am on board with these central moves of Nguyen’s book, in this essay I will argue that the situation is substantially messier than Nguyen portrays it as being. Game play, I will claim, is inextricably embedded and entangled in its larger social, material and cultural context. Conversely, I will argue, everyday life is routinely sculpted in ways Nguyen claims are distinctive of games. (shrink)

Psychiatry uncomfortably spans biological and psychosocial perspectives on mental illness, an idea central to Engel's biopsychosocial paradigm. This paradigm was extremely ambitious, proposing new foundations for clinical practice as well as a non-reductive metaphysics for mental illness. Perhaps given this scope, the approach has failed to engender a clearly identifiable research programme. And yet the view remains influential. We reassess the relevance of the biopsychosocial paradigm for psychiatry, distinguishing a number of ways in which it could be (re)conceived.

There is growing interest in political phenomenology in the role that affectivity and emotions play in the political realm. Broadly speaking, it has been suggested that political emotions fall into two sub-categories: political emotions of allegiance and political emotions of antagonism. However, what makes an emotion one of allegiance or one of antagonism has yet to be explored. In this chapter, we show how work done on the phenomenology of emotions, the phenomenology of sociality, and critical phenomenology, can inform our (...) understanding of political emotions. Inspired by frameworks from each of these fields respectively, we introduce three ‘levels’ of phenomenological analysis with regards antagonistic political emotions: (i) the antagonistic character of the emotion, (ii) the antagonistic role in group dynamics, and (iii) a critical reflection on the very notion of antagonistic. Through this three-pronged phenomenological analysis we show how we can better understand, and critique, the conceptualisation of political emotions of antagonism and allegiance as well as show that whether an emotion is considered one of allegiance or antagonism depends on what level of analysis is employed. (shrink)

O presente artigo tem por objetivo analisar oito dissertações de mestrado do Grufopees/CNPq-Ufes produzidas entre anos de 2018-2021, dialogando com seus diferentes níveis e pressupostos técnicos, metodológicos, epistemológicos e filosóficos. Apoia-se na pesquisa qualitativa, do tipo bibliográfica, fundamentada na análise epistemológica do conhecimento. Toma os pressupostos da Teoria do Agir Comunicativo de Jürgen Habermas, buscando dialogar com as produções em busca de consensos acerca do conhecimento produzido. Tem como participantes os autores-pesquisadores das dissertações, considerando para a produção, organização e categorização (...) dos dados a “Matriz Epistemológica”. A análise de dados se fundamenta nos “Círculos Argumentativos”, que se constituem pela via do discurso expresso pelos argumentos explícitos nos “atos de fala” dos sujeitos, que “desproblematizam” no plano discursivo a respeito da ação/prática, buscando identificar as relações estabelecidas entre pesquisador e participantes, a constituição do problema de pesquisa, os processos de pesquisa, a compreensão da realidade e as intenções de mudança. Evidencia-se uma forte atuação do grupo em processos de transformação inerentes à perspectiva teórico-metodológica da pesquisa-ação colaborativo-crítica, concebidas na elaboração de processos de formação continuada na perspectiva da inclusão escolar e de políticas para a formação em municípios capixabas. Nota-se a perspectiva do discurso expressa na aposta em empreender comunicativamente com os sujeitos de contexto um espaço de fala para expor opiniões por duas vias do discurso, tanto o discurso teórico, no qual as experiências e pretensões de verdade são tematizadas, quanto o discurso prático, no qual se tematiza e avalia se determinada norma de ação pode ser fundamentada. (shrink)

Based on fieldwork in Newmarket, England, and Kentucky, this paper examines the acts of looking that take place at international thoroughbred horse auctions. Racehorse caretakers employ bloodstock agents to select the yearling thoroughbred who will make the best racehorse as a 2-year-old and, hopefully, successful stallion or broodmare after retiring from the track as a 4- or 5-year old. The paper assesses the criteria used to assess yearlings: pedigree, conformation, and "that something extra."The paper concludes that the ambiguous status of (...) the bloodstock agent derives from the liminal task the agent performs, communicating with a young, nonhuman animal to discover the animal's essential properties. Selecting yearlings depends upon a process of divination that mitigates against the characterization of western thought as "rational" and opposed to decision-making processes conventionally thought of as "non-normal" or irrational. (shrink)

This paper suggests that the stories that thoroughbred breeders tell about racehorse reproduction can contribute to an understanding of their ideas about relatedness between humans. It examines the thoroughbred pedigree as it is presented in the English sales catalogue as a locus of complex ideas about heredity, fertility, and procreation. It argues that resistance within the industry to new reproductive technologies, including artificial insemination, can be understood in terms of ideas about relatedness between horses and, by implication, between people.This paper (...) is based upon extensive participant observation conducted within the horseracing industry based in the town of Newmarket, England. (shrink)

Este artigo tem como objetivo apresentar um diálogo entre a literatura que perpassa a temática entre os filósofos Jürgen Habermas e Immanuel Kant, e suas contribuições para pensarmos o campo da Educação. Caracteriza-se por um estudo bibliográfico, fundamentado na análise e interpretação da temática proposta. Aponta-se algumas aproximações relevantes da perspectiva habermasiana e o pensamento kantiano, sobretudo no que diz respeito a conceitos básicos como emancipação e conhecimento, apropriando-se dos sentidos e interpretações discutidas nas obras bibliográficas elencadas. A partir do (...) diálogo exposto, compreende-se as contribuições dos pressupostos comunicativos no campo educacional, na área de formação continuada de profissionais da educação, conduzindo assim a uma justiça social expressa por processos de ensino-aprendizagem, garantindo o preparo de profissionais da educação fundamentada na concepção de um professor reflexivo, pesquisador e que aprende com o coletivo, visando o atendimento às necessidades de seus estudantes. (shrink)

A ‘glitch’, the parallax gap brokered by communication technologies, is a hiccough in smooth technological operation, one that is both undeniable and unresolvable. The glitch draws attention to the inherent contradictions of the technological proffer to seamlessly augment and enhance a life unaided by technology. There is no life unaided by technology, and the glitch is what introduces to life the gap between failure and fantasy, self and other, individual and community, inside and outside, representation and nature. Communication technologies attempt (...) to dub these glitches an error in their pretense of connection. But the glitch is unavoidable. As a multi-media installation, 'glitch' draws attention to this confusion over connection and, as a mode of resistance, proffer spaces of tension--between technologies and the environments they condition. (shrink)

Revitalizing Classrooms brings together six diverse essays with the central purpose of providing a venue for scholar teachers from a number of disciplines to convey their individual journeys in pedagogical innovation.

This research note argues that political theorists of refuge ought to consider the experiences of refugees after they have received asylum in the Global North. Currently, much of the literature concerning the duties of states towards refugees implicitly adopts a blanket approach, rather than considering how varied identities may affect the remedies available to displaced people. Given the prevalence of racism, xenophobia, and homophobia in the Global North, and the growing norm of dissident persecution in foreign territory, protection is not (...) guaranteed after either territorial or legal admission. This research note considers the case of LGBTQ refugees in order to demonstrate the analytical potential of more inclusive and diverse normative approaches. Taking the origin and extension of harm seriously requires a conceptualization of sanctuary after asylum that accurately reflects the experiences of the displaced. In doing so, questions arise regarding the nature and efficacy of territorial asylum. (shrink)

This paper will examine intertextual references between the Dialogus of Tacitus and the letters of Pliny, in particular those regarding boar hunting. It will argue that there are clues in the letters of Pliny which can help us to understand the relationship between these two writers as well as the tone and purpose of the Dialogus. By studying Pliny's letters to Tacitus on hunting , one can see the specific reference to boars as an allusion to Marcus Aper, the chief (...) spokesperson for contemporary eloquence in the dialogue, indicating a degree of humor and irony in the Dialogus that is further displayed by the similarity of Pliny's opening exhortation in Epistle 1.6, ridebis et licet rideas, to the final words of the Dialogus, cum adrisissent, discessimus. Moreover, the dialogue between Pliny and Tacitus in Pliny's letters can be seen as an indication that the Dialogus itself may have been revised throughout the years, thus problematizing the debate about the “publication date” of the Dialogus. (shrink)

In this paper, I argue that although it is important to attend to injustices surrounding women's epistemic exclusions, it is equally important to attend to injustices surrounding women's epistemic inclusions. Partly in response to the historical exclusion of women's knowledge, there has been increasing effort among first-world actors to seek out women's knowledge. This trend is apparent in efforts to mainstream gender in climate change negotiation. Here, one is told that women's superior knowledge about how to adapt to climate change (...) makes them “poised to help solve and overcome this daunting challenge.” Pulling from the work of Miranda Fricker, I argue that such claims risk epistemically objectifying women. To illuminate the risk of women's epistemic objectification in climate change discourse, I offer a feminist analysis of current efforts to seek women's environmental knowledge, cautioning throughout that such efforts must reflect just epistemic relations. (shrink)

There has been a recent push to offer more food assistance programs at farmers markets. Yet, as more programs are developed for farmers markets, little input has been sought from those who are ultimately responsible for their implementation. This ethnographic study explores the experiences of farmers markets that have been early adopters of federal food assistance programs. Participant observation and in-depth interviews were used in six early-adopting markets to understand staff perspectives on the challenges and benefits of administering food assistance (...) programs. The results show that even markets with strong organizational capacity experienced significant burdens while operating food assistance programs. In addition, most worried about the sustainability of these programs due to the level of resources needed for their support. The findings suggest that calls to expand food assistance programs to all farmers markets will continue to be met with challenges as many markets will not have the capacity to operate them. Targeting farmers markets with strong organizational capacity may increase the probability of successful implementation, but building the organizational capacity of farmers markets may be necessary for widespread adoption. The study has implications for other sectors of civil society that are increasingly taking on the work of providing government programs. (shrink)

: Offering an introduction to both John Dewey's philosophy of education and the 4-H Youth Development Program, this paper draws clear connections between these two topics. Concepts explored include Dewey's principles of continuity and interaction, and contagion with respect to learning. Roles of educational leaders (including teachers) are investigated in the context of a discussion about the structuring of opportunities for students to develop habits of meaningful and life-long learning. Specific examples are described in depth to demonstrate, from a Deweyan (...) perspective, the educational process and value of 4-H participation. Brief comments are made about the place of 4-H in the U.S. system of public education. (shrink)

Recent advances in next generation sequencing along with high hopes for genomic medicine have inspired interest in genomic research with the newly dead. However, applicable law does not adequately determine ethical or policy responses to such research. In this paper we propose that such research stands at a crossroads between other more established biomedical clinical and research practices. In addressing the ethical and policy issues raised by a particular research project within our institution comparatively with these other practices, we illustrate (...) the moral significance of paying careful heed to where one looks for guidance in responding to ethical questions raised by a novel endeavor. (shrink)

Here I argue that aspects of Nietzsche's thought may be productively compared with the role played by the concept of ubuntu in talk of cultural renaissance in South Africa. I show that Nietzsche respects and writes for humanity conceived of in a vital sense, thereby imagining a sense of authenticity that may prove significant to talk of cultural renaissance in South Africa. I question the view that Nietzsche is an individualist, drawing on debate between Conway (1990) and Gooding-Williams (2001), concerning (...) the interpretation of ‘The Dance-Song' in Thus Spoke Zarathustra, as well as on the notion of reciprocity intrinsic to the concept of ubuntu (Shutte, 1993). South African Journal of Philosophy Vol. 26 (1) 2007: pp. 85-97. (shrink)

As a powerful tool in the production of knowledge, comparing plays a crucial part in the sciences and the humanities. This volume explores the relationship between comparing and narrating in epistemic practices and clarifies the ways in which narratives enable or impede practices of comparing. It takes into account related activities, such as measuring and classifying, modeling, establishing norms and categories, as well as organizing and popularizing knowledge, to analyze the ambivalent relationship between narratives, scientific explanation, and understanding. The contributions (...) bring out the epistemic role of narratives, and elucidate how narratives are connected to comparisons and scientific explanations."--Publisher description. (shrink)

This book brings together leading scholars and practitioners from the United States, Europe, and Asia. The contributors come from different disciplines, including medicine, criminology, sociology, psychology, forensic sciences, and law. As a group, they have the background to discuss and conduct research in the area and to propose and critique theories and typologies of animal cruelty. In addition, they have the expertise to evaluate policy issues and to recommend best practices for protecting animals and intervening with those who abuse or (...) neglect them. (shrink)

Changes in diet and related purchasing habits at a societal level have become a significant source of stress for farmers in recent years. The rise of vegetarianism and veganism means that the use of these dietary terms, and those who identify with them, may act as potential triggers for those working with livestock. This paper considers the specific methodological issue of how to position oneself within the research process in rural domains, with regards to personal identity related to diet. Focussing (...) on non-meat eaters conducting research with livestock farmers, it explores the moral implications and appropriateness of how and whether authors choose to truthfully present their own diet-related identities in research settings. Using ethnographic descriptions of personal experience as well as secondary source material, the authors conclude that three possible response behaviours at the farmer-researcher interface are available when it comes to potentially ‘exposing’ one’s dietary identity – to divulge, to dissemble, or to divert, and that each comes with its own ethical and moral challenges. We argue that the research field and the researcher’s personal world are separate, though blurred, realms and, while the collection of quality data is important to any study, behavioural decisions should always be undertaken with boundaries of safety, and emotional and moral comfort in mind. (shrink)

In this book, Andreas Serafim sets out to investigate the use of religious discourse, by which he means any reference to religious ideas, beliefs, and attitudes in public speaking contexts in classical Athens. Like Gunther Martin (Divine Talk: Religious Argumentation in Demosthenes, 2009), Serafim examines religion primarily as a tool for persuasion, but he differentiates himself from Martin’s book by offering a more comprehensive study: he aims to take into account all extant speeches from t...

Starting out from the presumption that inscriptions are texts indissolubly connected to the physical objects on which they are written, this collection of essays aims to provide a multi-disciplinary perspective on the physical and material aspects of writing in antiquity. It argues that there is a need to ‘increase modern sensibilities to material aspects of our texts which are often elided in modern printed editions’. This call is not new: recognition of the importance of the materiality of...

Irigaray's critique of the phallocentric subject's implicit dependence on the maternal-feminine “outside” is compelling. Her postulation of nonhierarchical sexual difference gives the relational world of woman specificity and Irigaray brings the subject's worldview to earth as merely the relation of the male human to the world. But the focus of her transvaluation remains largely anthropocentric; and she maintains too many aspects of the privilege of the subject's sovereignty as proper to male subjectivity. I suggest that, we need to extend Irigaray (...) and to think sexual difference beyond the human. Drawing from Elizabeth Grosz, Gilles Deleuze, Henri Bergson and Jakob Von Uexküll, I argue that we need to think life beyond the constitution of the organism as the continuous enmeshment of different milieus. Sexual difference is a force of differentiation that articulates relationships between organisms and organs as crucial aspects of many milieus that make up the Earth. Along with the sexually differentiated aspects of milieus, there are rhythms of difference constitutive of milieus that are not sexed. The first section of the essay describes Irigaray's conceptualization of sexual difference between humans. Then I turn to her engagement with the status of nonhuman animals in “Animal Compassion.” I suggest her approach in this essay is too anthropocentric and move to a discussion of Uexküll's thinking on milieus as a way to extend the concepts of difference and sexual difference into posthuman contexts. The essay concludes by reading Irigaray's concept of difference with Deleuze and Bergson. (shrink)