Nowadays, almost everyone seems to agree that science is facing an epistemological crisis – namely the replicability crisis – and that we need to take action. But as to precisely what to do or how...

Over the last decade, philosophers of science have extensively criticized the epistemic superiority of randomized controlled trials for testing safety and effectiveness of new drugs, defending instead various forms of evidential pluralism. We argue that scientific methods in regulatory decision-making cannot be assessed in epistemic terms only: there are costs involved. Drawing on the legal distinction between rules and standards, we show that drug regulation based on evidential pluralism has much higher costs than our current RCT-based system. We analyze these (...) costs and advocate for evaluating any scheme for drug regulatory tests in terms of concrete empirical benchmarks, like the error rates of regulatory decisions. (shrink)

Replicability is widely regarded as one of the defining features of science and its pursuit is one of the main postulates of meta-research, a discipline emerging in response to the replicability crisis. At the same time, replicability is typically treated with caution by philosophers of science. In this paper, we reassess the value of replicability from an epistemic perspective. We defend the orthodox view, according to which replications are always epistemically useful, against the more prudent view that claims that it (...) is useful in very limited circumstances. Additionally, we argue that we can learn more about the original experiment and the limits of the discovered effect from replications at different levels. We hold that replicability is a crucial feature of experimental results and scientists should continue to strive to secure it. (shrink)

In recent years, science and technology have made great progress towards a better understanding of fundamental biological mechanisms of the diseases. Physicians, relying just on their own clinical experience, have long recognized that each patient is different from every other patient in many aspects. It is a matter of simple facts that many patients die without responding to any treatment, while others with the same disease survive. In oncology, the variability of treatment response has been a long-standing problem. Nowadays, thanks (...) to genomics and post-genomics advancements, we have identified an indication for that individual variability: tumor heterogeneity. Each tumor has a different genomic basis... (shrink)

Science progresses through debate and disagreement, and scientific controversies play a crucial role in the growth of scientific knowledge. However, not all controversies and disagreements are progressive in science. Sometimes, controversies can be pseudoscientific; in fact, bogus controversies, and what seem like genuine scientific disagreements, can be a distortion of science set up by non-scientific actors. Bogus controversies are detrimental to science because they can hinder scientific progress and eventually bias science-based decisions. The first goal of this paper is to (...) elucidate the distinction between bogus and genuine scientific controversies and provide a qualitative methodology, based on the literature on expertise, for distinguishing between the two. We will illustrate six epistemic criteria for distinguishing bogus from genuine scientific debates in science and medicine. This heuristic strategy applies directly to scientific reports, and it relies mostly on the social structure of science. We will then apply the above criteria to a case study: the controversy over statins, which are widely prescribed drugs for reducing the level of cholesterol and preventing cardiovascular disease. (shrink)

Statistical evidence is pervasive in medicine. In this chapter we will focus on the reliability of randomized clinical trials (RCTs) conducted to test the safety and efficacy of medical treatments. RCTs are scientific experiments and, as such, we expect them to be replicable: if we repeat the same experiment time and again, we should obtain the same outcome (Norton 2015). The statistical design of the test should guarantee that the observed outcome is not a random event, but rather a real (...) effect of the treatments administered. However, for more than a decade now, we have been discussing a replicability crisis across different experimental disciplines including medicine: the outcomes of trials published in very prestigious journals often disappear when the experiment is repeated (see, e.g., Lehrer 2010, Begley and Ellis 2012, Horton 2015). -/- There are different accounts of the reason for this replicability crisis, ranging from scientific fraud to lack of institutional incentives to double-check someone else’s results. In this chapter we will use the replicability crisis as a thread to introduce some central issues in the design of scientific experiments in medicine. First, in section 1, we will see how replicability and statistical significance are connected: we can only make sense of the p-value of a trial outcome within a series of replications of the test. But in order to conduct these replications properly, we need to agree on the proper design of the experiment we are going to repeat. In particular, we need to prevent the preferences of the experimenters from biasing the outcome of the experiment. If there is such a bias, when the experiment is replicated by a third party, the observed outcome will vanish. In section 2, we will argue that trialists need to agree on the debiasing procedures and the statistical quality controls that feature in the trial protocol, if they want the outcome to be replicable. In section 3, we will make two complementary points. On the one hand, replicability per se is not everything: we need trial outcomes that are not only statistically significant but also clinically relevant. On the other hand, trials are not everything: the experts analyzing the evidence can improve the reliability of statistical evidence, although they sometimes fail; we need to further study how they make their decisions. In section 4, we will use a controversy about the overprescription of statins to show how non-replicable effects are obtained in trials and how experts may fail at detecting such flaws, if the commercial interests are big enough. (shrink)

Drugs addressing unmet medical needs can change the lives of millions. Developing and validating new drugs can, however, take many years. To streamline the assessment of new drugs, regulatory agencies have long established shortened review pathways. Among these programs, Accelerated Approval (AA) has recently come under scrutiny due to the U.S. Food and Drug Administration's decision to authorize Aducanumab, the first Alzheimer's disease drug. This decision attracted fierce criticism due to the allegedly insufficient evidence about the safety and efficacy of (...) the drug. While considerable scholarly attention has been devoted to this case, the ethical aspects of the AA regulatory pathway have so far remained relatively unexplored. In this paper, we set out to fill this gap. We illustrate six conditions that should be met for AA to be ethically acceptable: moral solicitude, evidence, risk mitigation, impartiality, sustainability, and transparency. We discuss such conditions and suggest practical steps to implement them in regulatory and oversight processes. Taken together, our six conditions represent a benchmark for assessing the ethical validity of AA processes and decisions. (shrink)

This Special Issue titled "Severe Uncertainty in Science, Medicine and Technology" aims to shed new light on the understanding of severe uncertainty and its multifaceted implications. The main idea of the papers of this collection is that, despite possible sophisticated statistical judgments towards future risks in science, medicine, and technology, severe forms of uncertainty still exist.While ignorance is usually assumed to be a total absence of knowledge, uncertainty often refers to the incompleteness of knowledge or information. In its extreme form, (...) this is called "severe uncertainty" but is also known as "fundamental," "radical," "deep," "great," or "genuine" uncertainty. A common characteristic of these... (shrink)

Since the advent of drug regulation in 1962, regulatory agencies have been in the practice of using strict standards to test the safety and efficacy of medical treatments and products. Regulatory agencies, such as the FDA, demand two full-fledged Randomized Clinical Trials demonstrating the safety and effectiveness of drugs to grant its marketing authorization. On the contrary, surgical treatments are left completely unregulated. There are several reasons explaining this difference, and all of them point to the difficulty of conducting well-designed (...) RCTs in surgery. However, we argue that none of these arguments is decisive and that, under certain conditions, surgical RCTs can be morally justified and methodologically sound. Although ethical constraints restrict the number of testable surgical procedures, and surgical trials might not be as dependable as pharmaceutical RCTs, our analysis suggests that, in certain cases, it is possible to obtain high-quality evidence about the safety and efficacy of surgical procedures. Untested surgical treatments may prove to be ineffective and harm patients. Therefore, regulation of surgical procedures seems not only morally acceptable and able to provide reliable scientific evidence, but also desirable and justified from an ethical-political standpoint. (shrink)

Among the philosophies of special sciences, Philosophy of Medicine is an emerging field, even though the relationship between philosophy and medicine dates back to ancient times. Since the 1980s, t...

Hooks et al. note that microbiota-gut-brain research suffers from serious methodological flaws and interpretative issues. We suggest two corrective measures: first, taking more seriously the need of interdisciplinary work; second, interpreting some of the methodological issues as ordinary challenges of standardization, typical of emerging disciplines.

It has now been more than a year since the start of the COVID-19 pandemic. Yet, despite the colossal and unprecedented scientific effort that has been put into it, many claims are still opaque, and many issues must be solved. Among these, one deserves the attention of philosophers of science: the scientific controversy about the theories of SARS-CoV-2 transmission. In this short paper, I analyze the debate between the droplet theory and the airborne theory of viral transmission. I argue that (...) the acceptance of the droplet theory has been due to the philosophical commitments of the dominant scientific actors to a specific theory of evidence, which has become dominant in western democracies, and to a specific set of non-epistemic values, rather than to scientific considerations alone. (shrink)

Medical research makes intensive use of statistics in order to support its claims. In this paper we make explicit an epistemological tension between the conduct of clinical trials and their interpretation: statistical evidence is sometimes discarded on the basis of an underlined Bayesian reasoning. We suggest that acknowledging the potentiality of Bayesian statistics might contribute to clarify and improve comprehension of medical research. Nevertheless, despite Bayesianism may provide a better account for scientific inference with respect to the standard frequentist approach, (...) Bayesian statistics is rarely adopted in clinical research. The main reason lies in the supposed subjective elements characterizing this perspective. Hence, we discuss this objection presenting the so-called Reference analysis, a formal method which has been developed in the context of objective Bayesian statistics in order to define priors which have a minimal or null impact on posterior probabilities. Furthermore, according to this method only available data are relevant sources of information, so that it resists the most common criticisms against Bayesianism. (shrink)

In the last decade, robustness has been extensively mentioned and discussed in biology as well as in the philosophy of the life sciences. Nevertheless, from both fields, someone has affirmed that this debate has resulted in more semantic confusion than in semantic clearness. Starting from this claim, we wish to offer a sort of prima facie map of the different usages of the term. In this manner we would intend to predispose a sort of “semantic platform” which could be exploited (...) by those who wish to discuss or simply use it. We do this by starting from a core distinction between the robustness of representations, which is a philosophy of science issue, and the representations of robustness, which instead pertains to science. We illustrate our proposal with examples from biology, physics and mathematics. (shrink)

Reasoning in medicine requires the critical use of a clinical methodology whose validity must be evaluated as well as its limits. In the last decade, an increasing amount of evidence has shown severe limitations and flaws in the conduct of prognostic studies. The main reason behind this fact is that prognostic judgments are at high risk of error. In this paper we investigate the pragmatic and illocutionary aspects of different forms of linguistic acts and judgments involved in clinical practice. More (...) specifically, we analyze the role of uncertainty with regard to ‘particular’ clinical judgments and its relation with ‘general’ evidence. Focusing on how prognostic judgments are formulated and justified, our main purpose is to highlight the explication, the structure and the limits of prognosis from a linguistic and epistemological perspective. (shrink)

The increasing success of the evidence-based policy movement is raising the demand of empirically informed decision making. As arguably any policy decision happens under conditions of uncertainty, following our best available evidence to reduce the uncertainty seems a requirement of good decision making. However, not all the uncertainty faced by decision makers can be resolved by evidence. In this paper, we build on a philosophical analysis of uncertainty to identify the boundaries of scientific advice in policy decision making. We start (...) by introducing a distinction between empirical and non-empirical types of uncertainty, and we explore the role of two non-empirical uncertainties in the context of policy making. We argue that the authority of scientific advisors is limited to empirical uncertainty and cannot extend beyond it. While the appeal of evidence-based policy rests on a view of scientific advice as limited to empirical uncertainty, in practice there is a risk of over reliance on experts beyond the legitimate scope of their authority. We conclude by applying our framework to a real-world case of evidence-based policy, where experts have overstepped their boundaries by ignoring non-empirical types of uncertainty. (shrink)

In De Trinitate XII Augustine refuses the idea that a family could be the image of God. This is curious, because the theologian that in De Trinitate elaborates a “communitarian model” of the Trinity – the Lover, the Beloved and the Love – at the same time does not see the image of God in the first natural community, the family. The purpose of this paper is to show the deeper reasons for this refutation. After the exposition of Augustine’s argument, (...) the paper identifies Augustine’s polemical reference to a part of the Eastern Tradition, which used the example of the first family (Adam, Eve and Abel/Seth) in order to express the mystery of the Trinity. It examines also how the example of the first family was used by Gregory of Nazianzus in his fifth theological discourse (which some scholars identify as the possible source of the idea of the family as the image of God for Augustine) in a trinitarian way. This study then considers two aspects of Augustine’s argument: that his refutation is not justified by the association of the Holy Spirit with the mother and the bride; that the real reason for it is exegetical, and dependent upon Augustine’s reading of Gn. 1:26. Finally the paper shows that the view of gender differences as merely corporeal is what prevents the Doctor of Grace from reading Gn. 1:27 in a relational-dialogical way to express the intimate communion of the Trinity. (shrink)

The first Chapter of Nāgārjuna’s Mūlamadhyamakakārikā offers a critique of causation that includes the Abhidharmic category of the ‘four conditions’. Following the South-Asian commentarial tradition, this article discusses the precise relationship between Madhyamaka philosophy and its fundamental Abhidharmic background. What comes to light is a more precise assessment of Madhyamaka ideas about viable conventions, understood as the process of dependent arising. Since this is primarily in the sense of conceptual dependence, it involves sentiency as a necessary causal element, and the (...) relationship between sentiency and conceptuality is highlighted by Nāgārjuna and his commentators. Viable conventions exclude the possibility of a non-contingent core, and the systems and categories that revolve around such non-contingent element (ātman) are discarded by the Madhyamaka even at a conventional level. (shrink)

Do I cause global warming, climate change and their related harms when I go for a leisure drive with my gas-guzzling car? The current verdict seems to be that I do not; the emissions produced by my drive are much too insignificant to make a difference for the occurrence of global warming and its related harms. I argue that our verdict on this issue depends on what we mean by ‘causation’. If we for instance assume a simple counterfactual analysis of (...) causation according to which ‘C causes E’ means ‘if C had not occurred, E would not have occurred’, we must conclude that a single drive does not cause global warming. However, this analysis of causation is well-known for giving counterintuitive results in some important cases. If we instead adopt Lewis’s analysis of causation, it turns out that it is indeterminate whether I cause global warming when I go for a single drive. Still, in contexts where we seek to control or understand global warming, there is a pressure to adopt a more fragile view of this event. When we adopt such a view, it turns out that a single drive does cause global warming. This means that we cannot like Sinnott-Armstrong and Kingston and Sinnott-Armstrong reject the idea that I should refrain from going for a leisure drive simply because such a drive does not cause global warming. (shrink)

In this paper I analyze a case of extreme response to need of security in the landscape of advanced democracies: the role of Golden Dawn in the management and reproduction of the profound socio-economic crisis in Greece. I argue that the keys behind the success of such a party are to be found in two distinct but self-reinforcing elements: its organizational strength and its anti-system ideology. The most significant organizational structures and activities which transformed Golden Dawn into a quasi-mafia style (...) “industry of private protection” are thus investigated, along with the most important contents of its radical and anti-systemic message. (shrink)

Based on Kolchinsky and Wolpert’s work on the semantics of autonomous agents, I propose an application of Mathematical Logic and Probability to model cognitive processes. In this work, I will follow Bateson’s insights on the hierarchy of learning in complex organisms and formalize his idea of applying Russell’s Type Theory. Following Weaver’s three levels for the communication problem, I link the Kolchinsky–Wolpert model to Bateson’s insights, and I reach a semantic and conceptual hierarchy in living systems as an explicative model (...) of some adaptive constraints. Due to the generality of Kolchinsky and Wolpert’s hypotheses, I highlight some fundamental gaps between the results in current Artificial Intelligence and the semantic structures in human beings. In light of the consequences of my model, I conclude the paper by proposing a general definition of knowledge in probabilistic terms, overturning de Finetti’s Subjectivist Definition of Probability. (shrink)

Background Traditionally, palliative care has focused on patients suffering from life-threatening somatic diseases such as cancer or progressive neurological disorders. In contrast, despite the often chronic, severely disabling, and potentially life-threatening nature of psychiatric disorders, there are neither palliative care units nor clinical guidelines on palliative measures for patients in psychiatry. Main text This paper contributes to the growing literature on a palliative approach in psychiatry and is based on the assumption that a change of perspective from a curative to (...) a palliative approach could help promote patient-centeredness and increase quality of life for severely ill patients in psychiatry as well as in somatic medicine. To exemplify this, we offer three different clinical scenarios: severe and enduring anorexia nervosa, treatment-refractory schizophrenia, and chronic suicidality and persistent self-injury in borderline personality disorder. Conclusion We emphasize that many typical interventions for treatment-refractory psychiatric disorders may indeed be of a palliative nature. Furthermore, introducing traditional features of palliative care, e.g. so-called goals of care conversations, could aid even further in ensuring that caregivers, patients, and families agree on which treatment goals are to be prioritized in order to optimize quality of life in spite of severe, persistent mental disorder. (shrink)

Orthodox Bayesianism is a highly idealized theory of how we ought to live our epistemic lives. One of the most widely discussed idealizations is that of logical omniscience: the assumption that an agent’s degrees of belief must be probabilistically coherent to be rational. It is widely agreed that this assumption is problematic if we want to reason about bounded rationality, logical learning, or other aspects of non-ideal epistemic agency. Yet, we still lack a satisfying way to avoid logical omniscience within (...) a Bayesian framework. Some proposals merely replace logical omniscience with a different logical idealization; others sacrifice all traits of logical competence on the altar of logical non-omniscience. We think a better strategy is available: by enriching the Bayesian framework with tools that allow us to capture what agents can and cannot infer given their limited cognitive resources, we can avoid logical omniscience while retaining the idea that rational degrees of belief are in an important way constrained by the laws of probability. In this paper, we offer a formal implementation of this strategy, show how the resulting framework solves the problem of logical omniscience, and compare it to orthodox Bayesianism as we know it. (shrink)

A proof-theoretic test for paradoxicality was famously proposed by Tennant: a paradox must yield a closed derivation of absurdity with no normal form. Drawing on the remark that all derivations of a given proposition can be transformed into derivations in normal form of a logically equivalent proposition, we investigate the possibility of paradoxes in normal form. We compare paradoxes à la Tennant and paradoxes in normal form from the viewpoint of the computational interpretation of proofs and from the viewpoint of (...) proof-theoretic semantics. (shrink)

In this paper, we present a new semantic framework designed to capture a distinctly cognitive or epistemic notion of meaning akin to Fregean senses. Traditional Carnapian intensions are too coarse-grained for this purpose: they fail to draw semantic distinctions between sentences that, from a Fregean perspective, differ in meaning. This has led some philosophers to introduce more fine-grained hyperintensions that allow us to draw semantic distinctions among co-intensional sentences. But the hyperintensional strategy has a flip-side: it risks drawing semantic distinctions (...) between sentences that, from a Fregean perspective, do not differ in meaning. This is what we call the ‘new problem’ of hyperintensionality to distinguish it from the ‘old problem’ that faced the intensional theory. We show that our semantic framework offers a joint solution to both these problems by virtue of satisfying a version of Frege’s so-called ‘equipollence principle’ for sense individuation. Frege’s principle, we argue, not only captures the semantic intuitions that give rise to the old and the new problem of hyperintensionality, but also points the way to an independently motivated solution to both problems. (shrink)

The traditional possible-worlds model of belief describes agents as ‘logically omniscient’ in the sense that they believe all logical consequences of what they believe, including all logical truths. This is widely considered a problem if we want to reason about the epistemic lives of non-ideal agents who—much like ordinary human beings—are logically competent, but not logically omniscient. A popular strategy for avoiding logical omniscience centers around the use of impossible worlds: worlds that, in one way or another, violate the laws (...) of logic. In this paper, we argue that existing impossible-worlds models of belief fail to describe agents who are both logically non-omniscient and logically competent. To model such agents, we argue, we need to ‘dynamize’ the impossible-worlds framework in a way that allows us to capture not only what agents believe, but also what they are able to infer from what they believe. In light of this diagnosis, we go on to develop the formal details of a dynamic impossible-worlds framework, and show that it successfully models agents who are both logically non-omniscient and logically competent. (shrink)

When a belief has been influenced, in part or whole, by factors that, by the believer's own lights, do not bear on the truth of the believed proposition, we can say that the belief has been, in a sense, arbitrarily formed. Can such beliefs ever be rational? It might seem obvious that they can't. After all, belief, supposedly, “aims at the truth.” But many epistemologists have come to think that certain kinds of arbitrary beliefs can, indeed, be rational. In this (...) paper, I want to do two things. First, I want to show that the claim that arbitrary beliefs can be rational is inconsistent with the conjunction of two other attractive claims: one saying that rationality requires a certain kind of epistemic immodesty, and one saying that rationality forbids certain kinds of self-ascriptions of epistemic luck. Second, I want to evaluate different ways one might respond to this inconsistent triad. I won't defend any response in particular, but I'll draw out some notable costs and benefits of each response, which may help shed light on the question of whether arbitrary beliefs can be rational. (shrink)

The institutionalization of a rights-based proportionality review shares a number of salient features and puzzles with the practice of contestation that the Socrates of the early Platonic dialogues became famous for. Understanding the point of Socratic contestation, and its role in a democratic polity, is also the key to understanding the point of proportionality based rights review. To begin with, when judges decide cases within the proportionality framework they do not primarily interpret authority. They assess reasons. Not surprisingly, they, like (...) Socrates, have been prone to the charge that they offend the values and traditions of the community. The article discusses four types of pathologies that occasionally infect democratic decision-making that rights-based proportionality review is particularly suited to identify. But more basic and equally important is a second kind of justification: Proportionality-based judicial review institutionalizes a right to contest the acts of public authorities and demand a public reasons-based justification. Having a legal remedy that allows for the contestation of acts by public authorities before an impartial and independent court and demanding its justification in terms of public reason is as basic a commitment of liberal democracy as the right to vote. The real question is not whether judicial review is democratically legitimate, but how judicial institutions ought to be structured to best serve their democracy-enhancing and rights protecting purpose. If Socrates was right to insist that the practice of contestation he engaged in deserves the highest praise in a democratic polity, it is equally true that a well structured and appropriately embedded court engaged in rights based proportionality review deserves to be embraced as a vital element of liberal constitutional democracy. (shrink)

We refine the intuitively appealing idea that you are blameworthy for something if it happened because you did not care enough. More formally: you are blameworthy for X (where X may be an action, omission, or outcome) just in case there is the right causal-explanatory relation between your poor quality of will and X. First, we argue that blameworthiness for actions, omissions, and outcomes is concerned with negative differences: you are blameworthy for the fact that X occurred instead of X*, (...) where X is worse than X*. Second, we argue that the way in which your quality of will is poor has to fit what you are blameworthy for. With these refinements, the account already gives intuitively correct verdicts in cases of forgetting, making a negative difference to a nevertheless good result, and doing an action with runaway consequences. We then discuss what the right causal-explanatory relation is and suggest that it is simply causation, understood in the right way. Here, we draw on the account of causation developed in Touborg, The Dual Nature of Causation. According to this account, there are two necessary and jointly sufficient conditions for causation. Roughly, C causes E rather than E* iff (a) C is process-connected to E, and (b) C makes E more secure and E* less secure. With this account of causation, our account of blameworthiness now also gives correct verdicts in omission, pre-emption, and switching cases, Frankfurt-style cases, and collective harm cases. (shrink)

Many theories of rational action are predicated on the idea that what it is rational to do in a given situation depends, in part, on what it is rational to believe in that situation. In short: they treat epistemic rationality as explanatorily prior to practical rationality. If they are right in doing so, it follows, on pain of explanatory circularity, that epistemic rationality cannot itself be a form of practical rationality. Yet, many epistemologists have defended just such a view of (...) epistemic rationality. According to them, there is no such thing as a distinctively epistemic form of rationality which could be explanatorily prior to practical rationality. Rather, they maintain, there is just one form of rationality—practical rationality—of which epistemic rationality is a species. What to make of this conflict? The aim of this paper is to motivate a view about the relationship between epistemic and practical rationality which resolves the conflict in a way that should be attractive to both sides. The central idea is to ground both epistemic and practical rationality in an independently motivated notion of evidential probability which is itself to be understood in non-normative terms. Doing so, I argue, allows us to unify epistemic and practical rationality in a way that does justice to the idea that what it is rational to do depends, in part, on what it is rational to believe; and to do so in a way that avoids explanatory circularity. (shrink)

Madhyamaka philosophers, like most Buddhist authors writing in Sanskrit and Pāli, often express their philosophical positions through the etymological expansion and interpretation of specific key terms. Their format and style reflect an attitude towards language that, while being largely shared by the entire Sanskrit tradition, is also attuned to uniquely Buddhist concerns. I shall here reconstruct and discuss some Sanskrit and Pāli etymologies, offering a possible context for the understanding of Madhyamaka thought in India. As it would be unfeasible to (...) analyze a large amount of terms, I focus on a few expressions that bear upon the question of how Mādhyamikas understand language, both as actual linguistic expression and, more broadly/figuratively, as the activity of conceptualization. I will propose a specific reading of the Sanskrit sources in terms of linguistic, lexical, and philosophical analysis. In particular, I interpret Candrakīrti as advocating a layered view of conventional truths. He restricts the perceptions and thoughts that may qualify as conventionally valid, so as to exclude impaired perception or distorting philosophical stances. These restrictions are embedded in his etymological explanation of key philosophical terms. In brief, when Candrakīrti discusses ‘worldly conventions’ or refers to ‘what is established in the world’, not everyone fits in his ‘world’. (shrink)

Evidentialism is the thesis, roughly, that one’s beliefs should fit one’s evidence. The enkratic principle is the thesis, roughly, that one’s beliefs should "line up" with one’s beliefs about which beliefs one ought to have. While both theses have seemed attractive to many, they jointly entail the controversial thesis that self-misleading evidence is impossible. That is to say, if evidentialism and the enkratic principle are both true, one’s evidence cannot support certain false beliefs about which beliefs one’s evidence supports. Recently, (...) a number of epistemologists have challenged the thesis that self-misleading evidence is impossible on the grounds that misleading higher-order evidence does not have the kind of strong and systematic defeating force that would be needed to rule out the possibility of such self-misleading evidence. Here I respond to this challenge by proposing an account of higher-order defeat that does, indeed, render self-misleading evidence impossible. Central to the proposal is the idea that higher-order evidence acquires its normative force by influencing which conditional beliefs it is rational to have. What emerges, I argue, is an independently plausible view of higher-order evidence, which has the additional benefit of allowing us to reconcile evidentialism with the enkratic principle. (shrink)

Should you always be certain about what you should believe? In other words, does rationality demand higher-order certainty? First answer: Yes! Higher-order uncertainty can’t be rational, since it breeds at least a mild form of epistemic akrasia. Second answer: No! Higher-order certainty can’t be rational, since it licenses a dogmatic kind of insensitivity to higher-order evidence. Which answer wins out? The first, I argue. Once we get clearer about what higher-order certainty is, a view emerges on which higher-order certainty does (...) not, in fact, license any kind of insensitivity to higher-order evidence. The view as I will describe it has plenty of intuitive appeal. But it is not without substantive commitments: it implies a strong form of internalism about epistemic rationality, and forces us to reconsider standard ways of thinking about the nature of evidential support. Yet, the view put forth promises a simple and elegant solution to a surprisingly difficult problem in our understanding of rational belief. (shrink)

In the last few years, the lack of a unitary notion of gene across biological sciences has troubled the philosophy of biology community. However, the debate on this concept has remained largely historical or focused on particular cases presented by the scientific empirical advancements. Moreover, in the literature there are no explicit and reasonable arguments about why a philosophical clarification of the concept of gene is needed. In our paper, we claim that a philosophical clarification of the concept of gene (...) does not contribute to biology. Unlike the question, for example, “What is a biological function?”, we argue that the question “What is a gene?” could be answered by means of empirical research, in the sense that biologists' labour is enough to shed light on it. (shrink)

In this paper I address issues related to the problem of future contingents and the metaphysical doctrine of fatalism. Two classical responses to the problem of future contingents are the third truth value view and the all-false view. According to the former, future contingents take a third truth value which goes beyond truth and falsity. According to the latter, they are all false. I here illustrate and discuss two ways to respectively argue for those two views. Both ways are similar (...) in spirit and intimately connected with fatalism, in the sense that they engage with the doctrine of fatalism and accept a large part of a standard fatalistic machinery. (shrink)

Abstract: Nietzsche’s famously wrote that “consciousness is a surface” (EH, Why I am so clever, 9: 97). The aim of this paper is to make sense of this quite puzzling contention—Superficiality, for short. In doing this, I shall focus on two further claims—both to be found in Gay Science 354—which I take to substantiate Nietzsche’s endorsement of Superficiality. The first claim is that consciousness is superfluous—which I call the “superfluousness claim” (SC). The second claim is that consciousness is the source (...) of some deep falsification—which I call the “falsification claim” (FC). I shall start by considering Nietzsche’s notion of consciousness. Here, I shall argue that the kind of consciousness he is concerned with is in fact self-consciousness and that he put forward a higher-order theory of it. Then, I shall address the two claims. Regarding (FC), my proposal will be that, according to Nietzsche, the content of (self-)conscious mental states is falsified in virtue of its being articulated propositionally. Regarding (SC), I shall claim that it is best read as a weak version of epiphenomenalism about conscious causation. In addressing both points, I shall discuss in particular the influential reading of Nietzsche’s theory of consciousness offered by Katsafanas (2005). (shrink)

Don’t form beliefs on the basis of coin flips or random guesses. More generally, don’t take belief gambles: if a proposition is no more likely to be true than false given your total body of evidence, don’t go ahead and believe that proposition. Few would deny this seemingly innocuous piece of epistemic advice. But what, exactly, is wrong with taking belief gambles? Philosophers have debated versions of this question at least since the classic dispute between William Clifford and William James (...) near the end of the nineteenth century. Here I reassess the normative standing of belief gambles from the perspective of epistemic decision theory. The main lesson of the paper is a negative one: it turns out that we need to make some surprisingly strong and hard-to-motivate assumptions to establish a general norm against belief gambles within a decision-theoretic framework. I take this to pose a dilemma for epistemic decision theory: it forces us to either make seemingly unmotivated assumptions to secure a norm against belief gambles, or concede that belief gambles can be rational after all. (shrink)

Guessing is a familiar activity, one we engage in when we are uncertain of the answer to a question under discussion. It is also an activity that lends itself to normative evaluation: some guesses are better than others. The question that interests me here is what makes for a good guess. In recent work, Dorst and Mandelkern have argued that good guesses are distinguished from bad ones by how well they optimize a tradeoff between accuracy and specificity. Here I argue (...) that Dorst and Mandelkern’s implementation of this idea fails to satisfy some plausible constraints on good guesses, and I develop an alternative implementation that satisfies the relevant constraints. The result is a new account of good guesses which retains the positive aspects of Dorst and Mandelkern’s proposal, but without the drawbacks. (shrink)

We often have reason to doubt our own ability to form rational beliefs, or to doubt that some particular belief of ours is rational. Perhaps we learn that a trusted friend disagrees with us about what our shared evidence supports. Or perhaps we learn that our beliefs have been afflicted by motivated reasoning or other cognitive biases. These are examples of higher-order evidence. While it may seem plausible that higher-order evidence should impact our beliefs, it is less clear how and (...) why. Normally, when evidence impacts our beliefs, it does so by virtue of speaking for or against the truth of theirs contents. But higher-order evidence does not directly concern the contents of the beliefs that they impact. In recent years, philosophers have become increasingly aware of the need to understand the nature and normative role of higher-order evidence. This is partly due to the pervasiveness of higher-order evidence in human life. But it has also become clear that higher-order evidence plays a central role in many epistemological debates, spanning from traditional discussions of internalism/externalism about epistemic justification to more recent discussions of peer disagreement and epistemic akrasia. This volume brings together, for the first time, a distinguished group of leading and up-and-coming epistemologists to explore a range of issues about higher-order evidence. (shrink)

This paper addresses a particular interpretation of quantum mechanics, i.e. superdeterminism. In short, superdeterminism i) takes the world to be fundamentally deterministic, ii) postulates hidden variables, and iii) contra Bell, saves locality at the cost of violating the principle of statistical independence. Superdeterminism currently enjoys little support in the physics and philosophy communities. Many take it to posit the ubiquitous occurrence of hard-to-digest conspiratorial and coincidental events; others object that violating the principle of statistical independence implies the death of the (...) scientific methodology. In this paper, we offer a defense to these and other objections. To counter the conspiracy objection, we draw upon the philosophical literature on time travel, and conclude that the picture of the world offered by the superdeterminist does not need to be particularly surprising or conspiratorial. We then move on to other recent objections, in particular those that focus on the methodology of science and the nature of the physical laws compatible with superdeterminism. A key ingredient of our arguments is that the principle of statistical independence may be violated in theory, but valid for practical purposes. Our overarching goal is to offer a defense of superdeterminism with respect to its main objections, so that it can earn its keep as a legitimate contender among the possible interpretations of quantum mechanics. (shrink)