This article seeks to open up a discussion of issues relating to the significance of sexual difference, the thinking and politics emerging from it and how it might affect educational philosophy. It briefly examines the initial work of Luce Irigaray, which has become quite influential in parts of the English speaking world, particularly focussing on the idea that there are implications for our educational objectives if gender equality were to be put in question as one of the underlying paradigms with (...) which to measure children's performance. It then looks at the work of some groups of Italian philosophers and educationalists who have not been translated into English and are consequently less well known. Their work has been devoted to exploring Irigaray's challenge to re-think the world from the perspective of sexual difference. In particular, in tune with the theme of this special issue, this article shows how this work puts forward the practice and philosophy of relationship for consideration at different stages of the educational process, focussing particularly on Luisa Muraro's philosophical ‘invention’ of the symbolic order of the mother as a way to bring into the shared world the erased sexual difference that Irigaray had articulated. Muraro's work considers the meaning of the first relationship between mother and infant and suggests that the mother, or the one doing her work, is in fact the first and ongoing educator and transmitter of philosophy, a fact that is only partially recognised in our formal educational structures. The article introduces, finally, the idea that as the historical patterns of mainly women teaching younger children and men teaching older children are shifting, to understand the need for and argue for a more sexuate world, with both sexes participating in the educational process at all stages would allow for the possibility of a new discussion of concepts that are already central to educationalists such as equality, freedom, autonomy, authority, flourishing and the relationship with parents. (shrink)

The practice of relationship itself is seen to be the central vehicle through which human beings learn and understand themselves, others, and the world around them. The politics of sexual difference insists that the flourishing of sexual difference in both women and men, girls and boys, relies, ultimately, on both sexes taking up the challenge to rethink themselves and the world. This chapter explores the emergence of a whole new philosophical idea, brought into being by Luce Irigaray in the context (...) of the women's movements of the 1960s and 1970s in Europe. It then outlines how this idea was developed in Italy and Spain to restore the work of the mother to the origins of what we understand as education and philosophy, emphasising the need to bring relationship itself as the vehicle for this process onto centre stage and keep it there. (shrink)

In this article, we explore smart deterrents and their historical precedents marketed to women and girls for the purpose of preventing harassment, sexual abuse and violence. Rape deterrents, as we define them, encompass customs, architectures, fashions, surveillant infrastructures, apps and devices conceived to manage and protect the body. Online searches reveal an array of technologies, and we engage with their prevention narratives and cultural construction discourses of the gendered body. Our critical analysis places recent rape deterrents in conversation with earlier (...) technologies to untangle the persistent logics. These are articulated with reference to the ways that proto-digital technologies have been imported into the realm of ubiquitous computing and networks. Our conceptual framework offers novel pathways for discussing feminine bodies and their messy navigation of everyday life that include both threats to corporeal safety and collective imaginings of empowerment. (shrink)

Villeneuve d’Ascq, Presses universitaires du Septentrion, 2018, 404 p. Cette collection d’essais commence avec une question provocatrice : d’autres cours d’Europe offrent-elles une place « aussi éminente » aux femmes que la cour de France à l’époque moderne? Les études réunies ici montrent de façon évidente l’importance et la centralité des femmes à la cour de France, des reines et princesses au sommet du pouvoir jusqu’aux demoiselles de musique, nourrices, femmes d’officiels et autres. Cet...

In the latter half of the twentieth century, philosophers of science have argued (implicitly and explicitly) that epistemically rational individuals might compose epistemically irrational groups and that, conversely, epistemically rational groups might be composed of epistemically irrational individuals. We call the conjunction of these two claims the Independence Thesis, as they together imply that methodological prescriptions for scientific communities and those for individual scientists might be logically independent of one another. We develop a formal model of scientific inquiry, define four (...) criteria for individual and group epistemic rationality, and then prove that the four definitions diverge, in the sense that individuals will be judged rational when groups are not and vice versa. We conclude by explaining implications of the inconsistency thesis for (i) descriptive history and sociology of science and (ii) normative prescriptions for scientific communities. (shrink)

Dominant views of personal identity in philosophy take some kind of psychological continuity or connectedness over time to be criterial for the identity of a person over time. Such views assign psychological states, particularly those necessary for narrative memory of some kind, special importance in thinking about the nature of persons. The extended mind thesis, which has generated much recent discussion in the philosophy of mind and cognitive science, holds that a person’s psychological states can physically extend beyond that person’s (...) body. Since “person” is a term of both metaphysical and moral significance, and discussions of both extended minds and personal identity have often focused on memory, this article explores the relevance of extended cognition for the identity of persons with special attention to neuroethics and memory. (shrink)

Modeling and computer simulations, we claim, should be considered core philosophical methods. More precisely, we will defend two theses. First, philosophers should use simulations for many of the same reasons we currently use thought experiments. In fact, simulations are superior to thought experiments in achieving some philosophical goals. Second, devising and coding computational models instill good philosophical habits of mind. Throughout the paper, we respond to the often implicit objection that computer modeling is “not philosophical.”.

In the intersection between eugenics past and present, disability has never been far beneath the surface. Perceived and ascribed disabilities of body and mind were one of the core sets of eugenics traits that provided the basis for institutionalized and sterilization on eugenic grounds for the first 75 years of the 20th-century. Since that time, the eugenic preoccupation with the character of future generations has seeped into what have become everyday practices in the realm of reproductive choice. As Marsha Saxton (...) (2000) and Adrienne Asch (2000, 2003) have forcefully argued, the use of prenatal screening technologies to facilitate the selective abortion of fetuses with features that signify disabling traits—the paradigm here being trisomy 21 in a fetus indicating Down Syndrome in the child—express a negative view of such disabilities sufficient to warrant terminating an otherwise wanted pregnancy. The eliminative structure of what Rosemary Garland Thompson (2012) has called eugenic logic persists in contemporary practices governing reproductive choice, social inclusion, and democratic participation and their relationship to disability. The tie between eugenics and contemporary disability studies suggests that eugenics and reflection on its history can also play a more positive role in disability politics. After focusing on eugenics in the first half of the paper, we will shift in the second half of the paper to eugenic resonances in contemporary thought and practice, concluding with some thoughts about ongoing practices of silencing and the very idea of eradicating disability. (shrink)

Epistemic decision theory (EDT) employs the mathematical tools of rational choice theory to justify epistemic norms, including probabilism, conditionalization, and the Principal Principle, among others. Practitioners of EDT endorse two theses: (1) epistemic value is distinct from subjective preference, and (2) belief and epistemic value can be numerically quantified. We argue the first thesis, which we call epistemic puritanism, undermines the second.

McCawley supplements his earlier book—which covers such topics as presuppositional logic, the logic of mass terms and nonstandard quantifiers, and fuzzy logic—with new material on the logic of conditional sentences, linguistic applications of type theory, Anil Gupta's work on principles of identity, and the generalized quantifier approach to the logical properties of determiners.

Despite the fact that the history of eugenics in Canada is necessarily part of the larger history of eugenics, there is a special role for oral history to play in the telling of this story, a role that promises to shift us from the muddled middle of the story. Not only has the testimony of eugenics survivors already played perhaps the most important role in revealing much about the practice of eugenics in Canada, but the willingness and ability of survivors (...) to share their own oral histories makes the situation in western Canada almost unique. Conversely, I also discuss the role that oral history plays in “surviving a eugenic past”, trading on the ambiguity of this phrase to reflect both on the survivorship of those who have been viewed as subhuman via some kind of eugenic lens and on the collective legacy with which Canada’s eugenic past presents us. (shrink)

Several current debates in the epistemology of testimony are implicitly motivated by concerns about the reliability of rules for changing one’s beliefs in light of others’ claims. Call such rules testimonial norms (tns). To date, epistemologists have neither (i) characterized those features of communities that influence the reliability of tns, nor (ii) evaluated the reliability of tns as those features vary. These are the aims of this paper. I focus on scientific communities, where the transmission of highly specialized information is (...) both ubiquitous and critically important. Employing a formal model of scientific inquiry, I argue that miscommunication and the “communicative structure” of science strongly influence the reliability of tns, where reliability is made precise in three ways. (shrink)

A study in the philosophy of mind, centred on the problem of 'intentionality' the sense in which emotions can be said to have objects, their relation to these objects, and the implications of this relation for our understanding of human action and behaviour. Dr Wilson sets his enquiry against a broad historical background on what distinguishes man from inanimate objects by describing both Cartesian view of man is matter plus mind and the neo-Wittgensteinian view that there is a dynamic (...) behavioural difference – causal notions being often inapplicable to human action. Dr Wilson goes on to show the controversies and arguments that arise from the notion of intentionality cannot be analysed in causal terms. Dr Wilson believes that this notion can be shown causally and sets out to prove it. Finally, he brings this argument to a larger context mentioning that it has far-reaching effects in natural and social sciences. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:On Women Englishing Homer RICHARD HUGHES GIBSON Seven kingdoms strove in which should swell the womb / That bore great Homer; whom Fame freed from tomb,” so begins the fourth of “Certain ancient Greek Epigrams ” that George Chapman placed at the head of his Odyssey at its debut in 1615.1 The epigram was no mere antiquarian dressing for the text. It suggests a historical parallel with the translator’s (...) own feat—for this Odyssey appeared on the heels of Chapman’s 1611 Iliad, the first complete English translation of Homer directly from the Greek. Indeed, the title page of that Iliad boasted, “Never before in any language truly translated” (italics mine). In “Englishing ” Homer (as he put it), Chapman had vanquished not only local rivals but also the whole international field.2 Through Chapman, England bore Homer anew. Yet within a few decades challengers appeared. An octogenarian Thomas Hobbes published an Odyssey translation in 1675 and an Iliad the following year. Alexander Pope’s versions (Iliad, 1715–1720; Odyssey, 1726) were bestsellers in the next century, yet others soon enough sought to better them, including the poet William Cowper (Iliad, 1791; Odyssey, 1809). The rate of Homeric production then intensified in the nineteenth century, becoming in Edith Hall’s apt phrase a “national pastime” in Victorian Britain—and, I would add, in the United States too.3 In the 1860s, a new English Iliad or Odyssey debuted nearly every year, making Matthew Arnold, then Professor of Poetry at Oxford, seem prescient in selecting “On Translating Homer” as the topic for his 1860 lecture series. Anglo-American output of new English Homers has been steady ever since. The opening decades arion 26.3 winter 2019 of our century have been especially high-yielding—more than ten new Iliads and eight new Odysseys have appeared in print alongside fresh editions of twentieth-century favorites. Digital versions now circulate, too. To Chapman we might thus reply: Once seven Greek cities strove to be Homer’s nurse; now seventy tomes vie to be his English verse. Run down the complete bibliography, and a pattern already hinted in my list of notables becomes pronounced: name after name after name belongs to a man. Flip around a bit, and one can often find traces of women in these volumes. Hobbes, for example, argued in the preface to his translations that women have as “just” a “pretence” (in the sense of “claim”) as men to the moral education afforded by heroic poems, though one might cynically read this as a marketing strategy.4 Pope readily acknowledged his debt to the scholarship of Anne Le Fèvre Dacier, Homer’s first French female translator, and listed prominent female supporters in the subscription lists at the front of his editions.5 Women thus long factored into the business of “Englishing” classical texts, though almost exclusively as paying audience members. For more than four centuries, Homer’s English audience listened to a boys’ choir. That tune has only just begun to change thanks to the efforts of three women: the classicist and nonfiction writer Caroline Alexander, who became the first woman to publish a complete English Iliad in 2015; Emily Wilson, Professor of Classical Studies at the University of Pennsylvania, who published the first English Odyssey by a female translator in 2017; and the poet Alice Oswald, whose selective translation of the Iliad, Memorial, appeared in 2011.6 By virtue of their appearance in such short order, these books have been, and surely will be henceforth, grouped together. And rightly so: ending the male monopoly on the English channel to Homer is a major development. The Homeric epics have not only shaped Western culture; they enjoy enduring prestige. You still need to know Homer to fancy yourself “well-read.” These three books are thus 36 on women englishing homer potent symbols. They mark the passage of English-speaking women from the audience of male efforts to curate and transmit tradition to participants in those endeavors—from the subscription lists, we might say, to the title page. We sell these translations short, though, if we allow their collective meaning to obscure the patent differences in Alexander’s, Wilson’s, and Oswald... (shrink)

Ray and Cooper (2024) present a clear and compelling argument for giving greater prioritization to environmental injustice in the work we do as bioethicists. Their discussion of justice and vulnera...

The article contributes to the debate on new materialism commenced by Sara Ahmed (2008). Taking up Lena Gunnarsson’s (2013) argument that erasing distinctions is no effective antidote to dualistic theorising, the article argues that Karen Barad’s (2003, 2007) theory is problematic on this count. Whereas Barad dilutes the theoretical distinction between mind and matter as well as that between the animate and the inanimate, the contention here is that it is ethically and politically vital to hold on to a notion (...) of subjectivity understood in terms of the capacity for experience, on account of which sentient being is exposed to suffering. This requires accentuating the passive dimension of subjectivity rather than merely the active dimension of matter. This article contests Barad’s reinscription of a masculinist devaluation of passivity on the grounds that only by moving beyond it can we overcome the hierarchical opposition of subject versus object and, in consequence, of mind versus matter. (shrink)

Soil balancing is widely used in organic farming, but little is known about the practice because technical knowledge and goals for the practice are produced and negotiated within an alternative community of practice (CoP). We used a review of the private soil balancing literature and semi-structured interviews with farmers and consultants to document the knowledge, shared meanings, and goals of key actors within the soil balancing CoP. Our findings suggest this CoP is dominated by discourse between private consultants and farmers, (...) with few contributions to or from scientists or the peer reviewed literature. The idea of soil balancing is centered around improving soil quality through adjustments in Base Cation Saturation Ratios (BCSR), and practitioners report a wide range of positive agronomic outcomes. For most soil balancers, however, BCSR is only one part of a broader approach to soil health management that also utilizes traditional soil fertility recommendations and soil health-building cultural management practices. Meanwhile, a survey of land grant university soil fertility specialists and the peer-reviewed literature documented a high degree of skepticism and a lack of scientific evidence that BCSR can boost crop yields. We conclude that this scientific discourse reflects a disconnect from the practices and meanings used in the soil balancing CoP. While tensions between the dominant and niche agricultural knowledge systems are not unique, we believe a better appreciation for the nuanced meanings and goals within the soil balancing CoP present an opening for expanded collaborations with scientists doing research on soil health. (shrink)

Drawing on her memories of growing up in a racially segregated South, the author argues not so much for the removal and erasure of Confederate memorials as for mutilating them or retaining a version of their presence glossed with an explanation for their rejection. Connecting the southern anti-Semitism and anti-Black racism of her youth, she explains the parallels and differences between German efforts to come to terms with the Holocaust and American efforts, southern and northern, to move beyond and make (...) reparation for both slavery and continuing twentieth- and twenty-first-century racism. (shrink)

According to Quine, Charles Parsons, Mark Steiner, and others, Russell’s logicist project is important because, if successful, it would show that mathematical theorems possess desirable epistemic properties often attributed to logical theorems, such as aprioricity, necessity, and certainty. Unfortunately, Russell never attributed such importance to logicism, and such a thesis contradicts Russell’s explicitly stated views on the relationship between logic and mathematics. This raises the question: what did Russell understand to be the philosophical importance of logicism? Building on recent work (...) by Andrew Irvine and Martin Godwyn, I argue that Russell thought a systematic reduction of mathematics increases the certainty of known mathematical theorems (even basic arithmetical facts) by showing mathematical knowledge to be coherently organized. The paper outlines Russell’s theory of coherence, and discusses its relevance to logicism and the certainty attributed to mathematics. (shrink)

Literary Nonfiction. ESCAPE FROM THE NINETEENTH CENTURY is a group of essays by cultural critic Peter Lamborn Wilson and tackles the notion of modern progress: Did the Nineteenth Century ever come to an end? Was the "Twentieth" Century just a rerun? And what about the Twenty-First Century, the New Millennium? Another lackluster confirmation of the Eternal Return? Another garden of secondhand time? If to know "History" as tragedy is to escape its repetition as farce, then perhaps we need to (...) look more deeply at this Past that won't stop haunting us. Two illuminated madmen--Charles Fourier and Friedrich Nietzsche--and two too-sane geniuses--J.P. Proudhon and Karl Marx--are enlisted in the breakout plan. (shrink)

Many scholars have pursued philosophical inquiry through empirical research. These empirical projects have been shaped—to varying degrees and in different ways—by philosophical questions, traditions, frameworks and analytic approaches. This issue explores the methodological challenges and opportunities involved in these kinds of projects. In this essay, we briefly introduce the nine projects featured in this issue and then address two key questions: First, how do these diverse contributors understand their empirical research as a mode of philosophical inquiry? And, second, what is (...) the value in engaging in empirical research oneself, as opposed to drawing on the empirical work of others? As the essays in this issue demonstrate, there is no single answer to these questions. Our hope is that these guiding questions—and the diverse and divergent answers offered within this special issue—might demonstrate the live and pressing methodological questions involved in integrating empirical research and philosophical inquiry. (shrink)

Abstract:This article provides a novel interpretation of the so-called transition to self-consciousness in The Phenomenology of Spirit, where Hegel argues that the failure of the protagonist consciousness to formulate an understanding of the world in terms of forces and laws necessitates the shift to an investigation of its own self-conscious subjectivity. The author argues that we can make sense of the transition by attending to Hegel's account of the metaphysical structure of forces and laws, on the one hand, and the (...) structure of self-consciousness, on the other. Following this approach, she argues that the transition represents the realization by the protagonist consciousness that the object of phenomenological inquiry must be metaphysically self-determining (or "infinite," in Hegel's terminology). The standpoint of self-consciousness accordingly emerges because the protagonist consciousness takes itself qua subject to exhibit the requisite self-determining structure. In addition to making sense of the transition to self-consciousness, this line of argumentation illuminates Hegel's subsequent focus on the activity of "desire.". (shrink)

As part of a series of case studies titled “In the Humanities Classroom,” this contribution reports in detail on the initial class taught by the author in the spring of 2015, during her time at Princeton University as a visiting lecturer in art history. By presenting students with three sets of devotional materials—two papier-mâché medallions painted by nuns at the convent of Wienhausen in northern Germany on the eve of the Reformation; a n'kisi n'kondi figure from the Yombe group of (...) Kongo peoples in the nineteenth-century; and a description, taken from Marilynne Robinson's novel Gilead, of a child baptizing kittens with creek water—the instructor raises questions about how materials convey holiness and influence viewers or worshippers. She prods history and literature students, both graduate and undergraduate, to take physical objects seriously as evidence, and she challenges those in art history to study objects and also texts normally regarded as outside of their purview. (shrink)

Taking Hobbesian logic as my starting point, I argue that Hobbesian diffidence, one of the causes of quarrel in the state of nature, does not disappear once the citizens enter civil society. Rather, diffidence is merely contained by the sovereign. Following Alice Ristroph, I argue that diffidence comes to shape what citizens demand of the state/sovereign in the criminal law. However, I show that Ristroph does not fully appreciate that the concept of diffidence is a racialized one, and as such, (...) race underlies how the citizens understand their own diffidence, what citizens demand of the sovereign, and how they demand it. Further, because diffidence itself is racialized, criminal law need not make explicit appeals to race. Once racialized diffidence becomes embedded in the criminal law, it remains there regardless of any conscious racial animus. I show that racial profiling is a prime example of how this racialized diffidence manifests. Thus, I present Hobbesian diffidence as a framework from which to understand racial oppression. This paper is primarily an application of Hobbes to contemporary issues rather than an exegesis and analysis of Hobbes’s views. (shrink)

This article examines how and why Ayn Rand uses fairy tales as intertexts in her novels. It argues that she evokes and revises fairy tales to exemplify the metaphysical values that her novels resist. For Rand, fairy tales like “Cinderella” are problematic because they typically endorse conventionality over the truly heroic. She therefore associates them with secondhanders and villains. She rejects their message that mindless conformity leads to happily-ever-after, and she exposes how fairy tales can be formidable vehicles for promoting (...) the senseless. She reinforces her point by contrasting them with her revisions of myths, which she associates with heroes. (shrink)

John Baldwin began his presidential address last year by remarking that such an address affords the opportunity to speak to colleagues and friends about “what you've been working on and pondering for the past couple of years.” What then have I been thinking about ? If I'm honest with myself, I must admit that what I've really been doing is wondering: did I get it right last time? For I find, as do many of you, I'm sure, that new research (...) arises from old, that new questions come because one reads new texts—or maybe even the same texts—and suddenly asks oneself: if this is what it says, can I really be right about what I thought last year or the year before? The work I am beginning on metamorphosis in the years around 1200 originates in my own questioning of conclusions I drew about the same period in my study of bodily resurrection. (shrink)

Friedrich Nietzsche has emerged as one of the most important and influential modern philosophers. For several decades, the book series Monographien und Texte zur Nietzsche-Forschung (MTNF) has set the agenda in a rapidly growing and changing field of Nietzsche scholarship. The scope of the series is interdisciplinary and international in orientation reflects the entire spectrum of research on Nietzsche, from philosophy to literary studies and political theory. The series publishes monographs and edited volumes that undergo a strict peer-review process. The (...) book series is led by an international team of editors, whose work represents the full range of current Nietzsche scholarship. (shrink)

Individualism in psychology is the view that mental states must be individuated so as to be intrinsic to particular individuals. This view has been thought to impose an intuitive and plausible constraint on explanation in psychology. The dissertation is a sustained examination of individualism, especially with respect to its role in psychological explanation. My particular interest is in showing that individualism is not a constraint on psychology which follows from either psychology's scientific nature, or from the nature of causation or (...) materialism. ;Apart from an extended introduction in which I explain why individualism is both a substantive and plausible constraint on taxonomy and explanation in psychology, the dissertation has three parts. The aim of Part One is to reconstruct and critically discuss three influential, recent arguments for individualism: an a priori argument , a empirical argument , and a methodological argument. I argue that each of these arguments is unsound and should be rejected. In an Appendix to Chapter 2 I argue that individualism does not follow from the causal theory of properties. ;In Part Two I turn to examine individualism itself. The aim of this part of the dissertation is to address the view that psychological kinds and explanations which are not individualistic cannot be part of an adequate account of mental causation. Chapter 5 both responds to particular charges that have been made about denials of individualism, and articulates and criticizes a central intuition about the local nature of causation from which individualism has sometimes been thought to follow. Chapter 6 focusses on folk psychology and attempts to show how one can view folk psychological explanation as unproblematically causal even though it is not individualistic. ;In Part Three I develop a core case against individualism using the concepts of causal depth and theoretical appropriateness, concepts which form the basis for two constraints on good causal explanations. I argue that individualism should be rejected because individualistic explanations of behavior, including individualistic psychological explanations, are not always the causally deepest or most theoretically appropriate explanations available. (shrink)

According to a prominent approach in contemporary formal semantics, the truth of moral assertions depends on a normative perspective imposed on the facts of the world. The implementation of this approach known as indexical contextualism treats the dependence of moral truth on the corresponding moral perspective in analogy with the contextual dependence characteristic of sentences containing indexical terms. Alternatively, the moral perspective is seen as configuring the circumstances of evaluation in which the content expressed by the occurrence of a moral (...) sentence is evaluated as true or false. The moderate version of this alternative view (non-indexical contextualism) considers that the truth of the occurrence of a moral sentence in a context of use is determined by the evaluation of its content in “the circumstance of the context”: the circumstance of evaluation represented by the same indexed set that represents the context of use. The radical version (assessment relativism), in turn, makes the truth of the occurrence of a moral sentence in a context depend essentially on the value of the normative standard in another context, from which the original utterance is assessed. Taking the judgment on the moral status of polygamous marriage as an illustration, the present work examines the competing merits of contextualist and relativist accounts of the use of moral language, especially in situations of disagreement and debate. The paper argues that, while indexical contextualism coupled with adequate pragmatic considerations can explain some relevant disagreement data, the alternative explanation of these data given by non-indexical contextualism is preferable, because it is simpler and more economical. It is also argued that relativism of assessment is better situated than non-indexical contextualism to explain the relevant phenomena of obligatory retraction and therefore to accommodate some discursive possibilities that play a central role in moral debates. (shrink)

Introduction : anthropological conversations across disciplines -- The presence of the past in culture : anthropology and history -- Space, place and culture : anthropology and geography -- Writing culture : anthropology and literature -- The science in culture : anthropology and biology -- The individual and culture : anthropology and psychology -- Culture and population : anthropology and demography.

Historical geographies of black people in Britain are sorely lacking within the geographical discipline. This is, perhaps, partly because finding histories of black people is relatively difficult. Photography has proved to be an interesting and practical way of recovering such histories, but the use of photography as a research tool raises questions about the inscription of race in Victorian and contemporary society. In this paper I draw attention to the methodological questions that have arisen while undertaking research that appears simultaneously (...) to undermine and to reinforce the issues of racialisation it attempts to deconstruct. (shrink)

In vertebrates, single cell analyses of replication timing patterns brought to light a very well controlled program suggesting a tight regulation on initiation sites. Mapping of replication origins with different methods has revealed discrete preferential sites, enriched in promoters and potential G‐quadruplex motifs, which can aggregate into initiation zones spanning several tens of kilobases (kb). Another characteristic of replication origins is a nucleosome‐free region (NFR). A modified yeast strain containing a humanized origin recognition complex (ORC) fires new origins at NFRs (...) revealing their regulatory role. In cooperation with NFRs, the histone variant H2A.Z facilitates ORC loading through di‐methylation of lysine 20 of histone H4. Recent studies using genome editing methods show that efficient initiation sites associated with transcriptional activity can synergize over several tens of kb by establishing physical contacts and lead to the formation of early domains of DNA replication demonstrating a co‐regulation between replication initiation and transcription. (shrink)