: All known life requires phosphorus (P) in the form of inorganic phosphate (PO43x or Pi) and phosphate-containing organic molecules. Pi serves as the backbone of the nucleic acids that constitute genetic material and as the major repository of chemical energy for metabolism in polyphosphate bonds. Arsenic (As) lies directly below P on the periodic table and so the two elements share many chemical properties, although their chemistries are sufficiently dissimilar that As cannot directly replace P in modern biochemistry. Arsenic (...) is toxic because As and P are similar enough that organisms attempt this substitution. We hypothesize that ancient biochemical systems, analogous to but distinct from those known today, could have utilized arsenate in the equivalent biological role as phosphate. Organisms utilizing such ‘ weird life ’ biochemical pathways may have supported a ‘ shadow biosphere ’ at the time of the origin and early evolution of life on Earth or on other planets. Such organisms may even persist on Earth today, undetected, in unusual niches. (shrink)

In his works on argumentation, Aristotle develops three main forms: apodeictical, dialectical, and rhetorical argumentation; dialectic is subdivided into several subspecies. The purpose of this paper is to discuss all of the forms described by Aristotle, to examine their differences and to point out their interrelations. This leads to an examination of the differentiating criteria and their applicability in the case of each argumentation form—and in particular to the question regarding the number of criteria that are necessary to describe each (...) form clearly and unambiguously. It is argued that Aristotle’s works on argumentation contain an implicit system of argumentation forms that is based on no more than three criteria. (shrink)

Simon Cushing conducted the following interview with Susan Wolf on 29 July 2016.

Susan Wolf, Meaning in Life and Why it Matters Content Type Journal Article Pages 1-2 DOI 10.1007/s10677-011-9321-8 Authors Simon Derpmann, Westfälische Wilhelms-Universität Münster, Philosophisches Seminar, Domplatz 23, 48143 Münster, Germany Journal Ethical Theory and Moral Practice Online ISSN 1572-8447 Print ISSN 1386-2820.

The Latin word lupus ‘wolf’ uniquely shares with Greek λύκος a metathesized form of Proto-Indo-European *u̯l̥kʷos, and it is unlikely that they could have arisen independently. But an early borrowing from Greek into the Italic languages can be justified, after metathesis took place, but before the changes to labiovelar consonants in each language that would exclude the possibility.

International relations are in constant turbulence. Globalisation, the rise and fall of superpowers, the fragilisation of the EU, trade wars, real wars, terrorism, persecution, new nationalism and identity politics, climate change, are just a few of the recent disturbing developments. How can international issues be understood and addressed from a Christian faith perspective? In this book answers are presented from various Christian traditions: Neo-calvinism, Catholic social teaching, critical theory and Christian realism. The volume offers fundamental theological and Christian philosophical perspectives (...) on international relations and global challenges, case studies about inspiring Christian leaders such as Robert Schuman, Dag Hammarskjöld, Abraham Kuyper and prophetic critiques of supranational issues. (shrink)

A partire dalla seconda metà del Novecento la questione della mostruosità è stata oggetto – insieme a quella del prodigio, da cui si differenzia soltanto parzialmente – di un crescente interesse accademico. Gli studi riguardanti la funzione antropologica, cosmologica, estetica e naturalistica dei mostri, sono oramai tanto numerosi e tanto vari nell'approccio da renderne ardua anche solo una parziale enumerazione. Difficilmente potremmo esimerci dal menzionare un autore come Jurgis Baltrušaitis, che così acutamente ha posto il tema della funzione estetica del (...) mostruoso e del deforme, e allo stesso modo non potremmo dimenticare gli ormai classici studi storici e interpretativi di Claude-Claire Kappler, Jean Céard, Jacques Le Goff, Leslie Fiedler o David Williams, la cui scelta di prender parte alla nostra rassegna ci ha sinceramente onorati. Così facendo, tuttavia, trascureremmo lavori davvero pregevoli, come (solo per dirne alcuni) il poderoso tomo prodotto da Lorraine J. Daston e Katharine Park, il prezioso volumetto di José Gil, la ricca raccolta a cura di Charles T. Wolfe, la voluminosa storia della teratologia di Olivier Roux e le profonde riflessioni di Richard Kearney. Sarebbe possibile proseguire con un elenco di molte pagine, che includerebbe senz'altro i molti e altrettanto degni di nota lavori di alcuni degli autori di questa raccolta, che, con gli altri, ringraziamo: Albrecht Classen, Peter G. Platt, Maddalena Mazzocut-Mis, David Gilmore... (shrink)

This essay responds to the helpful criticisms of Valuing Health: Well-Being, Freedom, and Suffering, which have been offered by Elselijn Kingma, Adam Oliver, Anna Alexandrova, Alex Voorhoeve, Erik Nord and James Wilson. I am extremely grateful to Jonathan Wolf and especially James Wilson for arranging a one-day conference on my book, Valuing Health: Well-Being, Freedom, and Suffering [Hausman, D.. Valuing Health: Well-Being, Freedom, and Suffering. Oxford: Oxford University Press.], and for publishing this symposium. I am also grateful to the wonderful (...) six scholars who took the time to study my work and to offer perceptive and helpful criticisms. Without unduly trying the patience of readers, I cannot respond to all their remarks, but I hope that in what follows I have replied to the most important of their comments on the arguments and conclusions of Valuing Health. Before I begin these replies, a brief synopsis of Valuing Health may be helpful to the reader. (shrink)

This collection of new articles brings together major scholars working at the intersection of traditional Chinese philosophy and mainstream analytic philosophy. For some 2,500 years, China's best minds have pondered the human condition, and yet their ideas are almost entirely ignored by mainstream philosophers and philosophy programs. The proposed volume is intended to take a step in remedying that situation by directing sinological resources to current topics in philosophy and doing so in a manner that speaks to practicing philosophers. Contributions (...) draw on a variety of sources across the Chinese tradition, from early Daoists and Confucians, to mid-imperial Buddhists and Neo-Confucians, right up to 20th Century philosophers. Some of the contemporary or recent philosophers whose works are discussed or challenged in this volume include Susan Wolf, Simon Blackburn, Jesse Prinz, Shaun Gallagher, Nel Noddings, John Rawls, Peter Singer, Stephen Buckle, Elizabeth Anscombe, Bernard Williams, Thomas Nagel, Graham Priest, Gilbert Ryle, W. V. Quine, Ernest Sosa, Harry Frankfurt, and David Velleman. (shrink)

Arsenic and phosphorus are group 15 elements with similar chemical properties. Is it possible that arsenate could replace phosphate in some of the chemicals that are required for life? Phosphate esters are ubiquitous in biomolecules and are essential for life, from the sugar phosphates of intermediary metabolism to ATP to phospholipids to the phosphate backbone of DNA and RNA. Some enzymes that form phosphate esters catalyze the formation of arsenate esters. Arsenate esters hydrolyze very rapidly in aqueous solution, which makes (...) it improbable that phosphorous could be completely replaced with arsenic to support life. Studies of bacterial growth at high arsenic:phosphorus ratios demonstrate that relatively high arsenic concentrations can be tolerated, and that arsenic can become involved in vital functions in the cell, though likely much less efficiently than phosphorus. Recently Wolfe‐Simon et al. 1 reported the isolation of a microorganism that they maintain uses arsenic in place of phosphorus for growth. Here, we examine and evaluate their data and conclusions. (shrink)

-/- Table des matières Remerciements 1 -/- INTRODUCTION 2 -/- PREMIERE PARTIE LE VIVANT ET LA REVOLUTION SCIENTIFIQUE 7 -/- ONTOLOGIE DU VIVANT OU BIOLOGIE ? LE CAS DE LA RÉVOLUTION SCIENTIFIQUE 8 -/- Introduction 8 La vie et le vivant sont-ils des thèmes de controverse explicites dans la philosophie naturelle de l’âge classique ? 18 Machines de la nature, ferments et métaphysique chimique 28 Crisis, what crisis ? 42 Conclusion 45 -/- LE MÉCANIQUE FACE AU VIVANT 49 -/- Introduction (...) 49 Que signifie : réduire l’homme (ou le vivant) à l’automate ? 51 Qu’est-ce qu’un vivant ? Un mécanisme élargi 56 Le vivant structuro-fonctionnel 64 Conclusion : l’automate affectif 70 -/- UN MATÉRIALISME VITAL ? 73 -/- Introduction : matérialisme et corps 73 Ontologie matérialiste de la Vie ou constitution progressive de la biologie ? 74 Un matérialisme vital 78 Conclusion 84 -/- DEUXIEME PARTIE MATÉRIALISMES ET VIE 87 -/- DÉTERMINISME MENTAL ET NATURALISATION DE L’ESPRIT, DE LOCKE A DIDEROT 88 -/- Introduction 89 Le déterminisme à l’âge classique et son interprétation 89 L’Âme Matérielle et le Traité de la liberté de l’âme : un déterminisme cérébral 94 Locke : la détermination est une perfection 101 Collins : suspendre son vouloir, c’est encore vouloir 105 Diderot : les « causes propres à l’homme » 111 Conclusion 115 -/- LA METTRIE : LA MÉDICALISATION DE LA MORALE ET L’APPROCHE MATÉRIALISTE DU CORPS 117 -/- Introduction 117 Une morale médicale ? 117 La réduction médicale de la morale 120 L’épicurisme médical 125 Une éthique machinale 130 Conclusion 132 -/- DES MOLÉCULES « INTELLIGENTES » A L’ORGANISATION ÉMERGENTE : LE DÉBAT MAUPERTUIS-DIDEROT 134 -/- Introduction 134 Le contexte newtonien et leibnizien 137 L’argument de Maupertuis 139 La critique de Diderot 143 La réponse de Maupertuis 145 Conclusion : enjeux de la discussion 147 -/- UNE BIOLOGIE CLANDESTINE ? LE PROJET D’UN SPINOZISME BIOLOGIQUE CHEZ DIDEROT 150 -/- Introduction 150 Diderot et la biologie 152 Excursus : la naissance de la biologie 155 Spinozistes anciens et modernes 161 Spinozisme et spinosisme 166 Conclusion 168 -/- TROISIEME PARTIE VITALISME 170 -/- ORGANISATION OU ORGANISME ? L’INDIVIDUATION ORGANIQUE SELON LE VITALISME MONTPELLIÉRAIN 171 -/- Introduction : pour introduire au vitalisme de Montpellier 171 Machine et organisation 174 Le concept vitaliste d’organisation, entre Vie et vies 179 Quelle individualité organique ? 186 Organisation ou organisme 190 Conclusion 197 -/- LES ANALOGIES NEWTONIENNES DANS LES SCIENCES DE LA VIE AU XVIIIE SIÈCLE : VITALISME ET PROCÉDÉS EXPLICATIFS PROVISOIREMENT INEXPLICABLES 200 -/- Introduction 200 Le newtonianisme médical littéral 206 Les transpositions non-littérales de la méthode newtonienne : Buffon, Maupertuis et Hartley 212 Haller : une physiologie de « noms d’attente » 216 Le vitalisme du XVIIIe siècle, un « positivisme prudent » plutôt qu’une « métaphysique impénitente » 220 L’antimathématisme de Mandeville et de Diderot 233 Conclusion 240 -/- VITALISME ET VIVISECTION : APPROCHES VITALISTES DE L’EXPÉRIMENTATION ANIMALE 245 -/- Introduction 245 Considérations préliminaires sur le XVIIe siècle 248 L’École de Montpellier 251 Ménuret de Chambaud 255 Un intermezzo sur Diderot 260 Fouquet et Bordeu contre Haller 263 Conclusion 267 -/- LE CHARME DISCRET DU VITALISME SANS MÉTAPHYSIQUE, XVIIIe - XXe SIÈCLES 272 -/- Introduction 272 Vitalisme substantiel et vitalisme fonctionnel 274 Vitalisme et biologie 279 Conclusion 283 -/- QUATRIEME PARTIE ORGANISME ET BIOPHILOSOPHIE 285 -/- L’ORGANISME : CONCEPT HYBRIDE ET POLÉMIQUE 285 -/- Introduction 286 L’organisme, un hybride 287 L’organisme comme individualité 290 Organisme et organicisme 296 L’organisme vitaliste 301 Ontologie de l’organisme 303 Conclusion 305 -/- LE RETOUR DU VITALISME : CANGUILHEM ET LE PROJET D’UNE BIOPHILOSOPHIE 307 -/- Introduction 307 Un vitalisme passe-partout 308 L’organisme entre épistémologie et ontologie 312 Une métaphysique de l’oursin ? Bioexceptionalisme et biochauvinisme 313 Vitalisme versus mysticisme de la chair 317 Conclusion 323 -/- HOLISME, ORGANICISME ET BIOCHAUVINISME 327 -/- Introduction : organicismes forts et faibles 327 Le holisme et l’organicisme plurivoques 329 Deux remarques critiques au sujet de deux périls étrangement connexes de la théorie holiste-organiciste 333 Holisme, biochauvinisme et subjectivité 337 Conclusion 341 -/- CONCLUSION : LA PHILOSOPHIE DE LA BIOLOGIE AVANT LA BIOLOGIE 345 -/- Bibliographie 350 Index 404. (shrink)

Unique in its collation of major theorists rarely considered together, Critical Environments incorporates detailed discussions of the work of Richard Rorty, Walter Benn Michaels, Stanley Cavell, Humberto Maturana, Francisco Varela, Niklas ...

What can reason do for us and what can't it do? This is the question examined by Herbert A. Simon, who received the 1978 Nobel Prize in Economic Sciences "for his pioneering work on decision-making processes in economic organizations." The ability to apply reason to the choice of actions is supposed to be one of the defining characteristics of our species. In the first two chapters, the author explores the nature and limits of human reason, comparing and evaluating the (...) major theoretical frameworks that have been erected to explain reasoning processes. He also discusses the interaction of thinking and emotion in the choice of our actions. In the third and final chapter, the author applies the theory of bounded rationality to social institutions and human behavior, and points out the problems created by limited attention span human inability to deal with more than one difficult problem at a time. He concludes that we must recognize the limitations on our capabilities for rational choice and pursue goals that, in their tentativeness and flexibility, are compatible with those limits. (shrink)

Scientific realism driven by inference to the best explanation (IBE) takes empirically confirmed objects to exist, independent, pace empiricism, of whether those objects are observable or not. This kind of realism, it has been claimed, does not need probabilistic reasoning to justify the claim that these objects exist. But I show that there are scientific contexts in which a non-probabilistic IBE-driven realism leads to a puzzle. Since IBE can be applied in scientific contexts in which empirical confirmation has not yet (...) been reached, realists will in these contexts be committed to the existence of empirically unconfirmed objects. As a consequence of such commitments, because they lack probabilistic features, the possible empirical confirmation of those objects is epistemically redundant with respect to realism. (shrink)

"Public reason" is one of the central concepts in modern liberal political theory. As articulated by John Rawls, it presents a way to overcome the difficulties created by intractable differences among citizens' religious and moral beliefs by strictly confining the place of such convictions in the public sphere. Identifying this conception as a key point of conflict, this book presents a debate among contemporary natural law and liberal political theorists on the definition and validity of the idea of public reason. (...) Its distinguished contributors examine the consequences of interpreting public reason more broadly as "right reason," according to natural law theory, versus understanding it in the narrower sense in which Rawls intended. They test public reason by examining its implications for current issues, confronting the questions of abortion and slavery and matters relating to citizenship. This energetic exchange advances our understanding of both Rawls's contribution to political philosophy and the lasting relevance of natural law. It provides new insights into crucial issues facing society today as it points to new ways of thinking about political theory and practice. (shrink)

Liberalism at the Crossroads provides a fair but lively introduction to key thinkers and schools of thought in the contemporary debate regarding liberal political theory.

This chapter explores the influence of Messianism on modern German thought. It analyzes philosophical and literary works on Messianic nationalism; Messianic suffering; National Socialism as Messianic ideology; and Jewish Messianism. Particular attention is given to the work of Martin Heidegger, who represents the most interesting crossroads between nationalist Messianism, ‘existential’ and deconstructionist anti-Messianism, and a residual religious Messianism.

Natural Law Today gives a strong voice to classical natural law theory as the best answers to the fundamental questions of ethics and as the best framework for political and social life. It explains various aspects of that theory and defends it against common misperceptions and criticisms.

In Ethics–Politics–Subjectivity, Simon Critchley takes up three questions at the centre of contemporary theoretical debate: What is ethical experience? What can be said of the subject who has this experience? What, if any, is the relation of ethical experience to politics? Through spirited confrontations with major thinkers, such as Lacan, Nancy, Rorty, and, in particular, Levinas and Derrida, Critchley finds answers in a nuanced “ethics of finitude” and defends the political possibilities of deconstruction. Democracy, economics, friendship, and technology are (...) all considered anew in Critchley’s bold excursions on the meaning and value of recent French philosophy. (shrink)

An original study of the philosophical problems associated with inductive reasoning. Like most of the main questions in epistemology, the classical problem of induction arises from doubts about a mode of inference used to justify some of our most familiar and pervasive beliefs. The experience of each individual is limited and fragmentary, yet the scope of our beliefs is much wider; and it is the relation between belief and experience, in particular the belief that the future will in some respects (...) resemble the past and the unobserved the observed, which forms the subject of this book. Dr Blackburn's first aim is to state the problem of induction properly, to show that there does exist a genuine problem immune to the solutions in vogue at present, yet no tin principle insoluble. He gives an extended and original account of the concept of a reason and goes on to discuss prediction. In the end Dr Blackburn produces a rationale for belief in certain short-term predictions based on his reinterpretation of the classical principle of indifference. He claims that a justification for induction can be found along the lines he has suggested and must indeed be found there if anywhere. (shrink)

Simon Glendinning explores both the difficulty and significance of the work of Derrida, arguing that his challenging ideas make a significant contribution to philosophy."--P. [2] of cover.

I explore the process of changes in the observability of entities and objects in science and how such changes impact two key issues in the scientific realism debate: the claim that predictively successful elements of past science are retained in current scientific theories, and the inductive defense of a specific version of inference to the best explanation with respect to unobservables. I provide a case-study of the discovery of radium by Marie Curie in order to show that the observability of (...) some entities can change and that such changes are relevant for arguments seeking to establish the reliability of success-to-truth inferences with respect to unobservables. (shrink)

Gilles Deleuze’s engagements with mathematics, replete in his work, rely upon the construction of alternative lineages in the history of mathematics, which challenge some of the self imposed limits that regulate the canonical concepts of the discipline. For Deleuze, these challenges provide an opportunity to reconfigure particular philosophical problems – for example, the problem of individuation – and to develop new concepts in response to them. The highly original research presented in this book explores the mathematical construction of Deleuze’s philosophy, (...) as well as addressing the undervalued and often neglected question of the mathematical thinkers who influenced his work. -/- In the wake of Alain Badiou’s recent and seemingly devastating attack on the way the relation between mathematics and philosophy is configured in Deleuze’s work, Simon Duffy offers a robust defence of the structure of Deleuze’s philosophy and, in particular, the adequacy of the mathematical problems used in its construction. By reconciling Badiou and Deleuze’s seeming incompatible engagements with mathematics, Duffy succeeds in presenting a solid foundation for Deleuze’s philosophy, rebuffing the recent challenges against it. -/- Simon B. Duffy is a Senior Lecturer in Philosophy at Yale-NUS College, Singapore, and Honorary Research Associate in the Department of Philosophy at the University of Sydney, Australia. He is the author of The Logic of Expression: Quality, Quantity, and Intensity in Spinoza, Hegel and Deleuze (2006). (shrink)

The Everett interpretation of quantum mechanics divides naturally into two parts: first, the interpretation of the structure of the quantum state, in terms of branching, and second, the interpretation of this branching structure in terms of probability. This is the second of two reviews of the Everett interpretation, and focuses on probability. Branching processes are identified as chance processes, and the squares of branch amplitudes are chances. Since branching is emergent, physical probability is emergent as well.

The main purpose of this paper is to refute the metaphysicians ‘methodological continuation’ argument supporting epistemic realism in metaphysics. This argument aims to show that scientific realists have to accept that metaphysics is as rationally justified as science given that they both employ inference to the best explanation, i.e. that metaphysics and science are methodologically continuous. I argue that the reasons given by scientific realists as to why inference to the best explanation is reliable in science do not constitute a (...) reason to believe that it is reliable in metaphysics. The justification of IBE in science and the justification of IBE in metaphysics are two distinct issues with only superficial similarities, and one cannot rely on one for the other. This becomes especially clear when one analyses the debate about the legitimacy of IBE that has taken place between realists and empiricists. The metaphysician seeking to piggyback on the realist defense of IBE in science by the methodological continuation argument presupposes that the defense is straightforwardly applicable to metaphysics. I will argue that it is, in fact, not. The favoured defenses of IBE in scientific realism make extensive use of empirical considerations, predictive power and inductive evidence, all of which are paradigmatically absent in the metaphysical context. Furthermore, I argue that the metaphysician, even if the realist would concede to the methodological continuation argument, fails to offer any agreed upon conclusions resulting from its application in metaphysics. As a result, the scientific realist is not committed to believing that there is metaphysical knowledge. (shrink)

This is a book about the religious life of the Greeks from the eighth century BC to the fifth century AD, looked at in the context of a variety of different cities and periods. Simon Price does not describe some abstract and self-contained system of religion or myths but examines local practices and ideas in the light of general Greek ideas, relating them for example, to gender roles and to cultural and political life (including Attic tragedy and the trial (...) of Socrates). He also lays emphasis on the reactions to Greek religions of ancient thinkers - Greek, Roman, Jewish and Christian. The evidence drawn on is of all kinds: literary texts, which are translated throughout; inscriptions, including an appendix of newly translated Greek inscriptions; and archaeology, which is highlighted in the numerous illustrations. (shrink)