This book explores Hume's account of reason and its role in human understanding, seen in the context of other notable accounts by philosophers of the early modern period. David Owen offers new interpretations of many of Hume's most famous arguments about induction, belief, scepticism, the passions, and moral distinctions.

This essay considers the role of the ‘all affected interests’ principle in democratic theory, focusing on debates concerning its form, substance and relationship to the resolution of the democratic boundary problem. It begins by defending an ‘all actually affected’ formulation of the principle against Goodin’s ‘incoherence argument’ critique of this formulation, before addressing issues concerning how to specify the choice set appropriate to the principle. Turning to the substance of the principle, the argument rejects Nozick’s dismissal of its intuitive appeal (...) and considers the two arguments advanced in favour of the principle as a criterion of democratic inclusion: the interlinked interests argument and the tracking power argument. It is shown that neither of these arguments can substantiate a view of the principle as a criterion of democratic inclusion, although both ground a constitutional understanding of the principle as specifying the scope of a duty of justification. It is then proposed that the principle can play an important role in a two-stage resolution of the democratic boundary problem in which it addresses the question of who is entitled to inclusion in the ‘pre-political’ demos that determines whether to constitute a polity. The second stage of this resolution requires an answer to the question of who should constitute the ‘political demos’, that is, the demos of a constituted polity and it is argued that a version of the ‘‘all subjected persons’’ principle can appropriately play this role.Keywords: all affected interests; all subjected persons; democracy; boundary problem; demos problem. (shrink)

" -- "New Scientist" Intended for anyone attempting to find their way through the large and confusingly interwoven philosophical literature on consciousness, ..

The following suggestions for the interpretation of Parmenides and Melissus can be grouped for convenience about one problem. This is the problem whether, as Aristotle thought and as most commentators still assume, Parmenides wrote his poem in the broad tradition of Ionian and Italian cosmology. The details of Aristotle's interpretation have been challenged over and again, but those who agree with his general assumptions take comfort from some or all of the following major arguments. First, the cosmogony which formed the (...) last part of Parmenides' poem is expressly claimed by the goddess who expounds it to have some measure of truth or reliability in its own right, and indeed the very greatest measure possible for such an attempt. Second, the earlier arguments of the goddess prepare the ground for such a cosmogony in two ways. For in the first place these arguments themselves start from assumptions derived from earlier cosmologists, and are concerned merely to work out the implications of this traditional material. And, in the second place, they end by establishing the existence of a spherical universe: the framework of the physical world can be secured by logic even if the subsequent introduction of sensible qualities or ‘powers’ into this world marks some decline in logical rigour. (shrink)

Logical monism is the claim that there is a single correct logic, the 'one true logic' of our title. The view has evident appeal, as it reflects assumptions made in ordinary reasoning as well as in mathematics, the sciences, and the law. In all these spheres, we tend to believe that there aredeterminate facts about the validity of arguments. Despite its evident appeal, however, logical monism must meet two challenges. The first is the challenge from logical pluralism, according to which (...) there is more than one correct logic. The second challenge is to determine which form of logicalmonism is the correct one. One True Logic is the first monograph to explicitly articulate a version of logical monism and defend it against the first challenge. It provides a critical overview of the monism vs pluralism debate and argues for the former. It also responds to the second challenge by defending a particularmonism, based on a highly infinitary logic. It breaks new ground on a number of fronts and unifies disparate discussions in the philosophical and logical literature. In particular, it generalises the Tarski-Sher criterion of logicality, provides a novel defence of this generalisation, offers a clearnew argument for the logicality of infinitary logic and replies to recent pluralist arguments. (shrink)

I argue that the hole argument is based on a misleading use of the mathematical formalism of general relativity. If one is attentive to mathematical practice, I will argue, the hole argument is blocked. _1._ Introduction _2._ A Warmup Exercise _3._ The Hole Argument _4._ An Argument from Classical Spacetime Theory _5._ The Hole Argument Revisited.

Ethical decision-making frameworks assist in identifying the issues at stake in a particular setting and thinking through, in a methodical manner, the ethical issues that require consideration as well as the values that need to be considered and promoted. Decisions made about the use, sharing, and re-use of big data are complex and laden with values. This paper sets out an Ethics Framework for Big Data in Health and Research developed by a working group convened by the Science, Health and (...) Policy-relevant Ethics in Singapore Initiative. It presents the aim and rationale for this framework supported by the underlying ethical concerns that relate to all health and research contexts. It also describes a set of substantive and procedural values that can be weighed up in addressing these concerns, and a step-by-step process for identifying, considering, and resolving the ethical issues arising from big data uses in health and research. This Framework is subsequently applied in the papers published in this Special Issue. These papers each address one of six domains where big data is currently employed: openness in big data and data repositories, precision medicine and big data, real-world data to generate evidence about healthcare interventions, AI-assisted decision-making in healthcare, public-private partnerships in healthcare and research, and cross-sectoral big data. (shrink)

The current prevailing view is that participation in biomedical research is above and beyond the call of duty. While some commentators have offered reasons against this, we propose a novel public goods argument for an obligation to participate in biomedical research. Biomedical knowledge is a public good, available to any individual even if that individual does not contribute to it. Participation in research is a critical way to support an important public good. Consequently, all have a duty to participate. The (...) current social norm is that individuals participate only if they have a good reason to do so. The public goods argument implies that individuals should participate unless they have a good reason not to. Such a shift would be of great aid to the progress of biomedical research, eventually making society significantly healthier and longer lived. (shrink)

A major problem for interpersonal aggregation is how to compare utility across individuals; a major problem for decision-making under normative uncertainty is the formally analogous problem of how to compare choice-worthiness across theories. We introduce and study a class of methods, which we call statistical normalization methods, for making interpersonal comparisons of utility and intertheoretic comparisons of choice-worthiness. We argue against the statistical normalization methods that have been proposed in the literature. We argue, instead, in favor of normalization of variance: (...) we claim that this is the account that most plausibly gives all individuals or theories ‘equal say’. To this end, we provide two proofs that variance normalization has desirable properties that all other normalization methods lack, though we also show how different assumptions could lead one to axiomatize alternative statistical normalization methods. (shrink)

G. E. L. Owen; VIII*—Aristotelian Pleasures, Proceedings of the Aristotelian Society, Volume 72, Issue 1, 1 June 1972, Pages 135–152, https://doi.org/10.1093/ar.

It has recently been argued that reproductive genetic manipulation technologies like mitochondrial replacement and germline CRISPR modifications cannot be said to save anyone’s life because, counterfactually, no one would suffer more or die sooner absent the intervention. The present article argues that, on the contrary, reproductive genetic manipulations may be life-saving (and, from this, have therapeutic value) under an appropriate population health perspective. As such, popular reports of reproductive genetic manipulations potentially saving lives or preventing disease are not necessarily mistaken, (...) though such terminology still requires further empirical validation. (shrink)

As opposed to a ‘one size fits all’ approach, precision medicine uses relevant biological, medical, behavioural and environmental information about a person to further personalize their healthcare. This could mean better prediction of someone’s disease risk and more effective diagnosis and treatment if they have a condition. Big data allows for far more precision and tailoring than was ever before possible by linking together diverse datasets to reveal hitherto-unknown correlations and causal pathways. But it also raises ethical issues relating to (...) the balancing of interests, viability of anonymization, familial and group implications, as well as genetic discrimination. This article analyses these issues in light of the values of public benefit, justice, harm minimization, transparency, engagement and reflexivity and applies the deliberative balancing approach found in theEthical Framework for Big Data in Health and Research to a case study on clinical genomic data sharing. Please refer to that article for an explanation of how this framework is to be used, including a full explanation of the key values involved and the balancing approach used in the case study at the end. Our discussion is meant to be of use to those involved in the practice as well as governance and oversight of precision medicine to address ethical concerns that arise in a coherent and systematic manner. (shrink)

I review the philosophical literature on the question of when two physical theories are equivalent. This includes a discussion of empirical equivalence, which is often taken to be necessary, and sometimes taken to be sufficient, for theoretical equivalence; and “interpretational” equivalence, which is the idea that two theories are equivalent just in case they have the same interpretation. It also includes a discussion of several formal notions of equivalence that have been considered in the recent philosophical literature, including (generalized) definitional (...) equivalence and categorical equivalence. The article concludes with a brief discussion of the relationship between equivalence and duality. The article is in two parts; this is Part 2, which addresses categorical equivalence, interpretational equivalence, and duality. (shrink)

Maturity and Modernity examines Nietzsche, Weber and Foucault as a distinct trajectory of critical thinking within modern thought which traces the emergence and development of genealogy in the form of imminent critique. David Owen clarifies the relationship between these thinkers and responds to Habermas' (and Dews') charge that these thinkers are nihilists and that their approach is philosophically incoherent and practically irresponsible by showing how genealogy as a practical activity is directed toward the achievements of human autonomy. The scope (...) of the book covers the critical methodologies developed by these thinkers with respect to the analysis of how we have become what we are and the implication which they draw for the possibility of human autonomy in the present. It proceeds by detailed analysis of each thinker in turn showing the structure of their approach, their historical account of the emergence of modernity, and the politics of their attempts to facilitate the achievement of human autonomy. (shrink)

This article provides an ethical analysis of the U.S. practice guideline update on disorders of consciousness. Our analysis focuses on the guideline’s recommendations regarding the use of investigational neuroimaging methods to assess brain‐injured patients. Complex and multifaceted ethical issues have emerged because these methods alter the clinical understanding of consciousness. We address issues of false hope, patient suffering, and cost. We argue that, in spite of these concerns, there is significant benefit to using neuroimaging to assess brain‐injured patients in most (...) cases. (shrink)

Why do people who disagree about one subject tend to disagree about other subjects as well? In this paper, we introduce a model to explore this phenomenon of ‘epistemic factionization’. Agents attempt to discover the truth about multiple propositions by testing the world and sharing evidence gathered. But agents tend to mistrust evidence shared by those who do not hold similar beliefs. This mistrust leads to the endogenous emergence of factions of agents with multiple, highly correlated, polarized beliefs.

As Harvey Brown emphasizes in his book Physical Relativity, inertial motion in general relativity is best understood as a theorem, and not a postulate. Here I discuss the status of the "conservation condition", which states that the energy-momentum tensor associated with non-interacting matter is covariantly divergence-free, in connection with such theorems. I argue that the conservation condition is best understood as a consequence of the differential equations governing the evolution of matter in general relativity and many other theories. I conclude (...) by discussing what it means to posit a certain spacetime geometry and the relationship between that geometry and the dynamical properties of matter. (shrink)

There has been a great deal of skepticism towards the value of the realism/anti-realism debate. More specifically, many have argued that plausible formulations of realism and anti-realism do not differ substantially in any way. In this paper, I argue against this trend by demonstrating how a hypothetical resolution of the debate, through deeper engagement with the historical record, has important implications for our criterion of theory pursuit and science policy. I do this by revisiting Arthur Fine’s ‘small handful’ argument for (...) realism and show how the debate centers on whether continuity should be an indicator for the future fruitfulness of a theory. I then demonstrate how these debates work in practice by considering the case of the Human Brain Project. I close by considering some potential practical considerations of formulating meta-inductions. By doing this, I contribute three insights to the current debate: 1) demonstrate how the realism/anti-realism debate is a substantive debate, 2) connect debates about realism/anti-realism to debates about theory choice and pursuit, and 3) show the practical significance of meta-inductions. (shrink)

The “best-medical-interests” standard for reporting findings does not go far enough. Research subjects have a right to know about any comprehensible piece of information about them that is generated by research in which they are participating. An even broader standard may sometimes be appropriate: if subjects agree to accept information that they may not understand, then all information may be disclosed.

At Metaphysics A 5 986a22-b2, Aristotle refers to a Pythagorean table, with two columns of paired opposites. I argue that 1) although Burkert and Zhmud have argued otherwise, there is sufficient textual evidence to indicate that the table, or one much like it, is indeed of Pythagorean origin; 2) research in structural anthropology indicates that the tables are a formalization of arrays of “symbolic classification” which express a pre-scientific world view with social and ethical implications, according to which the presence (...) of a principle on one column of the table will carry with it another principle within the same column; 3) a close analysis of Aristotle's arguments shows that he thought that the table expresses real causal relationships; and 4) Aristotle faults the table of opposites with positing its principles as having universal application and with not distinguishing between those principles that are causally prior and those that are posterior. Aristotle's account of scientific explanation and his own explanations that he developed in accordance with this account are in part the result of his critical encounter with this prescientific Pythagorean table. (shrink)

I provide an alternative characterization of a "standard of rotation" in the context of classical spacetime structure that does not refer to any covariant derivative operator.

The celu of the philosophical literature on the hole argument is the 1987 paper by Earman \& Norton ["What Price Space-time Substantivalism? The Hole Story" Br. J. Phil. Sci.]. This paper has a well-known back-story, concerning work by Stachel and Norton on Einstein's thinking in the years 1913-15. Less well-known is a connection between the hole argument and Earman's work on Leibniz in the 1970s and 1980s, which in turn can be traced to an argument first presented in 1975 by (...) Howard Stein. Remarkably, this thread originates with a misattribution: the argument Earman attributes to Stein, which ultimately morphs into the hole argument, was not the argument Stein gave. The present paper explores this episode and presents some reflections on how it bears on the subsequent literature. (shrink)

Background Several jurisdictions, including Singapore, Australia, New Zealand and most recently Ireland, have a public interest or public good criterion for granting waivers of consent in biomedical research using secondary health data or tissue. However, the concept of the public interest is not well defined in this context, which creates difficulties for institutions, institutional review boards and regulators trying to implement the criterion. Main text This paper clarifies how the public interest criterion can be defensibly deployed. We first explain the (...) ethical basis for requiring waivers to only be granted to studies meeting the public interest criterion, then explore how further criteria may be set to determine the extent to which a given study can legitimately claim to be in the public interest. We propose an approach that does not attempt to measure magnitude of benefit directly, but rather takes into account metrics that are more straightforward to apply. To ensure consistent and justifiable interpretation, research institutions and IRBs should also incorporate procedural features such as transparency and public engagement in determining which studies satisfy the public interest requirement. Conclusion The requirement of public interest for consent waivers in secondary biomedical research should be guided by well-defined criteria for systematic evaluation. Such a criteria and its application need to be periodically subject to intra-committee and intra-institution review, reflection, deliberation and amendment. (shrink)

David Brink presents a study of T. H. Green's Prolegomena to Ethics (1883), a classic of British idealism. Green develops a perfectionist ethical theory that brings together the best elements in the ancient and modern traditions and that provides the moral foundations for Green's own influential brand of liberalism. Brink's book situates the Prolegomena in its intellectual context, examines its main themes, and explains Green's enduring significance for the history of ethics and contemporary ethical theory.

Volume 19, Issue 7, July 2019, Page 28-30.

It is generally unquestioned that human subjects research review boards should assess the ethical acceptability of protocols. It says so right on the tin, after all: they are explicitly called research ethics committees in the UK. But it is precisely those sorts of unchallenged assumptions that should, from time to time, be assessed and critiqued, in case they are in fact unfounded. John Stuart Mill's objection to suppressers of dissent is instructive here: “If the opinion is right, they are deprived (...) of the opportunity of exchanging error for truth: if wrong, they lose, what is almost as great a benefit, the clearer perception and livelier impression of truth, produced by its collision with error”.1 Andrew Moore and Andrew Donnelly's compelling article, “The job of ‘ethics committees’”, is just this sort of challenge to conventional wisdom, a rejection of the notion that review boards should be considering ethical matters at all.2 If true, we should be substantially reforming our research ethics policies. And if false, rebuttals would help strengthen and ground the otherwise unquestioned assumption of the role of ethics committees. As it happens, I will argue that their critiques fall into the second category. While mistaken, they present a valuable opportunity to clarify the role of ethics committees and their relationship to relevant codes. In particular, I will defend a hybrid account where codes have strict primacy, but leave significant room for review boards …. (shrink)

With the recent report of a live birth after use of Mitochondrial replacement therapy, sometimes called ‘Three-parent IVF’, the clinical application of the technique is fast becoming a reality. While the United Kingdom allows the procedure under regulatory scrutiny, it remains effectively outlawed in many other countries. We argue that such prohibitions may violate individuals’ procreative rights, grounded in individuals’ interest in genetic affinity. The interest in genetic affinity was recently endorsed by Singapore’s highest court, reflecting an emphasis on the (...) importance of biological ties found across the globe. We apply that reasoning to make the case for a right to ‘Three-parent IVF’. (shrink)

At the beginning of his section “Of Miracles,” Hume mentions an argument of Dr. Tillotson. The doctrine of “the real presence” seems contradicted by our senses. We see a piece of bread, but are asked to believe it consists in the substance of the body of Christ.