Although the Ca2+‐dependent proteinase (calpain) system has been found in every vertebrate cell that has been examined for its presence and has been detected in Drosophila and parasites, the physiological function(s) of this system remains unclear. Calpain activity has been associated with cleavages that alter regulation of various enzyme activities, with remodeling or disassembly of the cell cytoskeleton, and with cleavages of hormone receptors. The mechanism regulating activity of the calpain system in vivo also is unknown. It has been proposed (...) that binding of the calpains to phospholipid in a cell membrane lowers the Ca2+ concentration, [Ca2+], required for the calpains to autolyze, and that autolysis converts an inactive proenzyme into an active protease. Recent studies, however, show that the calpains bind to specific proteins and not to phospholipids, and that binding to cell membranes does not affect the [Ca2+] required for autolysis. It seems likely that calpain activity is regulated by binding of Ca2+ to specific sites on the calpain molecule, with binding to each site eliciting a response (proteolytic activity, calpastatin binding, etc.) specific for that site. Regulation must also involve an, as yet, undiscovered mechanism that increases the affinity of the Ca2+‐binding sites for Ca2+. (shrink)

In a recent contribution to Learning for Democracy, Richard Bailey argues that Thomas Kuhn advocated an indoctrinatory model of science education, which is fundamentally authority-based. While agreeing with Bailey’s conclusion, this article suggests that Kuhn was attempting to solve an important problem which Bailey only touches on – how to ensure that science students do not become hypercritical. It continues by offering a critical rationalist solution to this problem, arguing that paradigms qua exemplars should be historical problem-solving episodes, rather (...) than model solutions to puzzles. (shrink)

When a doctor tells you there’s a one percent chance that an operation will result in your death, or a scientist claims that his theory is probably true, what exactly does that mean? Understanding probability is clearly very important, if we are to make good theoretical and practical choices. In this engaging and highly accessible introduction to the philosophy of probability, Darrell Rowbottom takes the reader on a journey through all the major interpretations of probability, with reference to real–world (...) situations. In lucid prose, he explores the many fallacies of probabilistic reasoning, such as the ‘gambler’s fallacy’ and the ‘inverse fallacy’, and shows how we can avoid falling into these traps by using the interpretations presented. He also illustrates the relevance of the interpretation of probability across disciplinary boundaries, by examining which interpretations of probability are appropriate in diverse areas such as quantum mechanics, game theory, and genetics. Using entertaining dialogues to draw out the key issues at stake, this unique book will appeal to students and scholars across philosophy, the social sciences, and the natural sciences. (shrink)

Schwitzgebel (2001) — henceforth 'S' — offers three examples in order to convince us that there are situations in which individuals are neither accurately describable as believing that p or failing to so believe, but are rather in 'in-between states of belief'. He then argues that there are no 'Bayesian' or representational strategies for explicating these, and proposes a dispositional account. I do not have any fundamental objection to the idea that there might be 'in-between states of belief'. What I (...) shall argue, rather, is that: (I) S does not provide a convincing argument that there really are such states; (II) S does not show, as he claims, that 'in-between states of belief' could not be accounted for in terms of degrees of belief; (III) S’s dispositional account of 'in-between states of belief' is more problematic than the 'degree of belief' alternative. (shrink)

In Medicine, Society, and Faith in the Ancient and Medieval Worlds Darrel Amundsen explores the disputed boundaries of medicine and Christianity by focusing on the principle of the sanctity of human life, including the duty to treat or attempt to sustain the life of the ill. As he examines his themes and moves from text to context, Amundsen clarifies a number of Christian principles in relation to bioethical issues that are hotly debated today. In his examination of the moral stance (...) of the earliest syphilographers, for example, he finds insights into the ethical issues surrounding the treatment of AIDS, which he believes has its closest historical antecedent not in plague but in syphilis. He also shows that the belief that all healing comes from God, whether directly, through prayer, or through the use of medicine -- a sentiment commonly held by contemporary Christians -- cannot be accurately attributed to any extant source from the patristic period. Indeed, all the Church Fathers were convinced that healing sometimes came from evil sources: Satan and his demons were able to heal, for example, and Asclepius was a demon "to be taken very seriously indeed.". (shrink)

In this piece, I advocate and motivate a new understanding of thought experiments, which avoids problems with the rival accounts of Brown and Norton.

According to the standard no miracles argument, science’s predictive success is best explained by the approximate truth of its theories. In contemporary science, however, machine learning systems, such as AlphaFold2, are also remarkably predictively successful. Thus, we might ask what best explains such successes. Might these AIs accurately represent critical aspects of their targets in the world? And if so, does a variant of the no miracles argument apply to these AIs? We argue for an affirmative answer to these questions. (...) We conclude that if the standard no miracles argument is sound, an AI-specific no miracles argument is also sound. (shrink)

"The ancient and modern question of what is the nature of man and his activity and what ought to be the directions pursued in this activity is once again being ...

What constitutes cognitive scientific progress? This Element begins with an extensive survey of the contemporary debate on how to answer this question. It provides a blow-by-blow critical summary of the key literature on the issue over the past fifteen years, covering the central positions and arguments therein. It also draws upon older literature, where appropriate, to inform the treatment. The Element then enters novel territory by considering meta-normative issues concerning scientific progress. It focuses on how the standards involved in assessing (...) progress arise. Does science have aims, which determine what counts as progress, as many authors assume? If so, what is it to be an aim of science? And how does one identify such things? If not, how do normative standards arise? After arguing that science does not have overarching aims, the Element proposes that the standards are ultimately subjective. (shrink)

From the Introduction: This inquiry is concerned with the themes of praxis and action in four philosophic movements: Marxism, existentialism, pragmatism, and analytic philosophy. It is rare that these four movements are considered in a single inquiry, for there are profound differences of emphasis, focus, terminology, and approach represented by these styles of thought. Many philosophers believe that similarities among these movements are superficial and that a close examination of them will reveal only hopelessly unbridgeable cleavages. While respecting the genuine (...) fundamental differences of these movements, this inquiry is undertaken in the spirit of showing that there are important common themes and motifs in what first appears to be a chaotic babble of voices. I intend to show that the concern with man as an agent has been a primary focal point of each of these movements and further that each contributes something permanent and important to our understanding of the nature and context of human activity. (shrink)

Increasing global economic integration and recent military interventions in the name of human rights have forced questions of global justice into political discussions. Is the unequal distribution of wealth across the globe just? What's wrong with imperialism? Are the most indebted countries obligated to pay back their loans to international financ.

It is appropriate to open an essay in honor of someone by commemorating that person. When I think of Dallas Willard I think of someone who has not been afraid to point to Jesus and spiritual commitment in an age when most people are committed to themselves. Dallas has been very clear in all of his writings that knowing Jesus is not a hobby, a business transaction one makes and forgets, nor an add-on to life; it is an entry into (...) a journey God is to direct in the context of the uniqueness of His person and the enablement of His rule and presence. The Father leads, Jesus mediates and exemplifies, and the Spirit enables. This commitment to Jesus is the goal of this article. It deals with unique claims about Jesus within the Second Temple Judaism of the first century, as well as looking at what religious life was like in the first century Greco-Roman world. Such background might seem distant in a journal on spiritual formation, but let me warn you that is not the case. To understand the world in which “decisions” for Jesus were made is to appreciate what it took to receive Jesus and begin the journey with Him. The study hopes to show that Willard's emphasis that genuine faith in Jesus is life-changing came with the first century territory. I proceed in three parts: the Jewish context, the Greco-Roman context, and then the application. (shrink)

Hepatitis B virus infects about 200 million people worldwide yearly. The consequences of the infection range from mild, self‐limiting hepatitis with full recovery and immunity to chronic infection with liver disease of varying severity, including fulminant hepatitis and death. Alternatively, individuals may become healthy carriers of the virus and thus serve as a reservoir of infection. In addition, all chronic carriers of the virus are also at risk for development of primary hepatocellular carcinoma later in life. Efforts to combat this (...) disease on a global scale require an inexpensive vaccine. Studies of the hepatitis B viral coat protein (HBsAg) have permitted the development of two generations of vaccine to date, and detailed structural studies of its antigenic sites may eventually allow the development of a completely synthetic (and therefore inexpensive) vaccine in the future. (shrink)

Thomas Aquinas, one of the "founding fathers" of just war theory, offers an account of virtuous warfare in practice. The author argues that Aquinas's approach to warfare, with its emphasis on justice and charity, is helpful in providing a coherent moral account of war to which Christians can subscribe. Particular attention is given to the role of charity, since this virtue is the distinguishing characteristic of the Christian soldier. Charity compels him to soldier justly, and by fighting justly, he is (...) elevated by God to friendship with God. Notable features of this approach are its emphasis on the criteria for judging whether a war is just and its relativizing of the criteria for proper combat behavior. (shrink)

"A fascinating and timely treatment of the objectivism versus relativism debates occurring in philosophy of science, literary theory, the social sciences, ...

This book offers students a philosophical introduction to the ethical foundations of business management. It combines lessons from Kant with virtue ethics and also touches upon additional approaches such as utilitarianism. At the core of the book lies the concept of the nexus of imperfect managerial duty: building and reinforcing the virtuous managerial team, engaging in reasoned discourse among all stakeholders, and diligently pursuing business responsibilities, including the creative efforts necessary for modern organizations. Case illustrations of these applications are presented (...) throughout the book, including chapter appendices. Ancillary videos, test and answer banks and sample syllabi are available online via the author’s website. (shrink)

Drawing freely and expertly from Continental and analytic traditions, Richard Bernstein examines a number of debates and controversies exemplified in the works of Gadamer, Habermas, Rorty, and Arendt. He argues that a "new conversation" is emerging about human rationality—a new understanding that emphasizes its practical character and has important ramifications both for thought and action.

Building on the views of Kant and early nineteenth century life scientists, Hegel develops a view of systems that is a clear precursor to the developments in Ludwig von Bertalanffy’s general system theory, as well as the thinking of the ecologically minded system thinkers that built upon the foundation Bertalanffy laid. Hegel describes systems as organic wholes in which the parts respectively serve as means and ends. Further, in the Encyclopedia version of the logic Hegel notes that such systems are (...) comprised of three processes: gestalt, the process of assimilation, and regeneration. In Hegel’s texts, he describes both natural and social systems as organic wholes with such systematic processes. In this paper, these processes and systems are described and it is argued that Hegel quite consistently applies views developed in the logic when describing systems. The paper shows how this parallels later developments in systems theory and goes on to show some distinctions between Hegel’s view of systems and that of later ecologically minded system thinkers. (shrink)

The term 'systems theory' is used to characterize a set of disparate yet related approaches to fields as varied as information theory, cybernetics, biology, sociology, history, literature, and philosophy. What unites each of these traditions of systems theory is a shared focus on general features of systems and their fundamental importance for diverse areas of life. Yet there are considerable differences among these traditions, and each tradition has developed its own methodologies, journals, and forms of anaylsis. This book explores this (...) terrain and provides an overview of and guide to the traditions of systems theory in their considerable variety. The book draws attention to the traditions of systems theory in their historical development, especially as related to the humanities and social sciences, and shows how from these traditions various contemporary developments have ensued. It provides a guide for strains of thought that are key to understanding 20th century intellectual life in many areas. (shrink)

In this paper I argue that resource allocation in publicly funded medical systems cannot be done using a purely substantive theory of justice, but must also involve procedural justice. I argue further that procedural justice requires institutions and that these must be “local” in a specific sense which I define. The argument rests on the informational constraints on any non-market method for allocating scarce resources among competing claims of need. However, I resist the identification of this normative account of local (...) justice with the actual approach to local decision-making taken within the UK National Health Service. I illustrate my argument with reference to the case of provision of In Vitro Fertilisation within the UK NHS. (shrink)

To Serve With Honor should be required reading for all members of the officer corps of the United States military. Beyond that, it should be made required reading for all United States military academies, ROTC and officer candidate programs. This treatise on military ethics goes a long way in bridging the gap between the military and society's understanding of the military's ethical dilemma. It is a must for the student of military affairs. International Social Science Review To Serve With Honor (...) is the first book by an American to focus on the validity of current standards of military ethics in more than a century. This thoughtful study begins with the premise that the military profession is qualitatively different from any other profession. Author Richard Gabriel uses this assumption to address such vital questions as What are the limits of military obedience? and When does a soldier have an obligation to resist the orders of his superiors? (shrink)

"A climate crisis and other pressures on planetary ecology are causing profound anxieties. Climate change threatens to trap hundreds of millions of people in dire poverty and to separate further an already deeply divided world. However, a new generation of activists is offering inspiration, serving as a hope-maker. This book offers an accessible and empirically informed philosophical discussion of climate change, global poverty, justice, and the importance of political responses, both internationally and domestically, that offer hope. There are reasons enough (...) to worry that the era of pervasive human planetary impact, the Anthropocene, could produce terrible global injustices and massive environmental destruction. But that need not be so. Since the Industrial Revolution growth in productive capacity and the egalitarian struggles to share its benefits widely have made another world possible. We still have reason to hope for a world in which international cooperation to manage Earth systems sustainably prevails, in which the natural treasures of the Earth are valued, in which a vision of prosperity is realized and the scourges of disease, ignorance, and poverty are overcome, in which powerful lobbies defending private interests that threaten sustainability are minimized and contained, and in which democratic politics responding to the values of an educated public prevail. The work of bringing about such a world is the work of mobilizing hope"--. (shrink)