Recent work suggests that DNA replication origins are regulated by the number of multiple mini‐chromosome maintenance (MCM) complexes loaded. Origins are defined by the loading of MCM – the replicative helicase which initiates DNA replication and replication kinetics determined by origin's location and firing times. However, activation of MCM is heterogeneous; different origins firing at different times in different cells. Also, more MCMs are loaded in G1 than are used in S phase. These aspects of MCM biology are explained by (...) the observation that multiple MCMs are loaded at origins. Having more MCMs at early origins makes them more likely to fire, effecting differences in origin efficiency that define replication timing. Nonetheless, multiple MCM loading raises new questions, such as how they are loaded, where these MCMs reside at origins, and how their presence affects replication timing. In this review, we address these questions and discuss future avenues of research. (shrink)

Transcript of discourses recorded in 1991 at Art of Living International Centre, Bangalore, India.

Corporate Governance (CG) issues have driven organisations to set their house right. There is a continual effort by organisations to build on a good framework of policies, not only as an undertaking enforced by a regulatory body, but also to sustain and win. However, these organisations are facing a dilemma in terms of their focus priority. Is it the composition of the board or is it the employee as the stakeholder that has high determining power to reach their goals. The (...) aim of this article is to build upon a structure of enablers of good governance. The paper utilises the Interpretive Structural Modelling (ISM) methodology to understand the mutual influence among the various enablers in such a fashion that the enablers having high driving power and dependency power can be identified. (shrink)

The practice of paying prisoners to for their participation in research has long been debated, and the controversy is reflected in the differing policies in the U.S. prison systems. Empirical study of financial payments to inmates who enroll in research has focused on whether this practice is coercive. In this study, we examined whether monetary incentives have the potential to be unduly influential among fifty HIV‐positive prisoners. The majority of prisoners surveyed believed that inmates should receive some compensation for their (...) involvement in research and disagreed with statements suggesting that the offer of payment constitutes undue influence. However, a sense of potentially being susceptible to undue influence was significantly higher among participants who had spent a longer time in prison and had less education. Overall, our findings suggest that most prisoners feel that they would be able to make a decision about research enrollment that is not solely based on an offer of monetary payment. (shrink)

Commentators have noted that the issue stands taken by each side of the American “culture war” lack conceptual consistency and can even seem contradictory. We sought to understand the psychological underpinnings of culture war attitudes using Moral Foundations Theory. In two studies involving 24,739 participants and 20 such issues, we found that endorsement of five moral foundations predicted judgments about these issues over and above ideology, age, gender, religious attendance, and interest in politics. Our results suggest that dispositional tendencies, particularly (...) a person’s moral intuitions, may underlie, motivate, and unite ideological positions across a variety of issues and offer new insights into the multiple “moral threads” connecting disparate political positions. (shrink)

Immunology researchers are beginning to explore the possibilities of reproducibility, reuse and secondary analyses of immunology data. Open-access datasets are being applied in the validation of the methods used in the original studies, leveraging studies for meta-analysis, or generating new hypotheses. To promote these goals, the ImmPort data repository was created for the broader research community to explore the wide spectrum of clinical and basic research data and associated findings. The ImmPort ecosystem consists of four components–Private Data, Shared Data, Data (...) Analysis, and Resources—for data archiving, dissemination, analyses, and reuse. To date, more than 300 studies have been made freely available through the ImmPort Shared Data portal , which allows research data to be repurposed to accelerate the translation of new insights into discoveries. (shrink)

REMARKS ON EVOLUTION AND TIME-SCALES, Graham Cairns-Smith; HODGSON'S BLACK BOX, Thomas Clark; DO HODGSON'S PROPOSITIONS UNIQUELY CHARACTERIZE FREE WILL?, Ravi Gomatam; WHAT SHOULD WE RETAIN FROM A PLAIN PERSON'S CONCEPT OF FREE WILL?, Gilberto Gomes; ISOLATING DISPARATE CHALLENGES TO HODGSON'S ACCOUNT OF FREE WILL, Liberty Jaswal; FREE AGENCY AND LAWS OF NATURE, Robert Kane; SCIENCE VERSUS REALIZATION OF VALUE, NOT DETERMINISM VERSUS CHOICE, Nicholas Maxwell; COMMENTS ON HODGSON, J.J.C. Smart; THE VIEW FROM WITHIN, Sean Spence; COMMENTARY ON HODGSON, Henry (...) Stapp. (shrink)

Rice cultivation is one of the most important agricultural activities on earth, with nearly 90% of it being produced in Asia. It belongs to the family of crops that includes wheat, maize and barley, and it supplies more than 50% of calories consumed by the world population. Its immense economic value and a relatively small genome size makes it a focal point for scientific investigations, so much so that four whole genome sequence drafts with varying qualities have been generated by (...) both public and privately funded ventures. The availability of a complete and high‐quality map‐based sequence has provided the opportunity to study genome organization and evolution. Most importantly, the order and identity of 37,544 genes of rice have been unraveled. The sequence provides the required ingredients for functional genomics and molecular breeding programs aimed at unraveling intricate cellular processes and improving rice productivity. BioEssays 28: 421–432, 2006. © 2006 Wiley Periodicals, Inc. (shrink)

INDUS-EM is India’s only level one conference imparting and exchanging quality knowledge in acute care. Specifically, in general and specialized emergency care and training in trauma, burns, cardiac, stroke, environmental and disaster medicine. It provides a series of exchanges regarding academic development and implementation of training tools related to developing future academic faculty and residents in Emergency Medicine in India. The INDUS-EM leadership and board of directors invited scholars from multiple institutions to participate in this advanced educational symposium that was (...) held in Thrissur, Kerala in October 2013. (shrink)

Institutional investors, policy makers, and researchers have advocated for greater director independence in hopes of improving corporate governance and discouraging unethical behaviors such as corporate frauds, accounting irregularities, and other organizational failures. However, increasing demands upon directors and sitting CEOs, as well as constraints on the number of boards on which they can serve, has resulted in a dramatic increase in the use of retired independent directors. Compared to other directors with full-time job demands, we argue that RIDs have lesser (...) time constraints and greater attentional capacities with which to discharge their responsibilities, thereby improving overall board “bandwidth.” Using S&P 1500 firms for the period of 2000–2012, we find that enhanced board bandwidth associated with an increased proportion of RIDs on the board relates to greater resource provisioning through reducing costs of capital, improved monitoring through reducing disclosure-related weaknesses, and better accounting and market performance. We thereby advance traditional board bandwidth research by contemplating the available time that independent directors would have by virtue of being retired and relating this to board effectiveness. (shrink)

Karl Raimund Popper, (1902-1994) a leading apostle of antiinductivism, holds that the main problem of philosophy of science is the problem of demarcation. Accordingly, the demarcation principle distinguishes science from non-science. To Popper, logic, metaphysics and psychoanalysis are likely to fall into the non-science group. Principle of induction has been accepted even though resentfully as the chief tool of scientific investigation by the positivists as well as the scientists in general. Popper rejects the positivistic approach and on the contrary proposes (...) falsifiablity to furnish his iconoclastic project. This paper intends to indentify the problem of his very approaches in order to hold that in spite of some difficulties in the problem of induction itself, as the identifier of science, we do not have any alternative to save science from metaphysics. Finally, Popper’s so-called demarcation criterion is extensively examined here with a view to defend material aspect of inductive generalization. Philosophy and Progress, Vol#67-68; No#1-2; Jan-Dec 2020 P 33-48. (shrink)

During the Twentieth Century, either before or after the Independence, India produced several saints. Many of these saints have preached and still preach a religion of love and devotion, the bhakti. Nowadays, many of the bhakti movements they have created are still active and other new movements are being born with the emergence of new saint-figures. Among all these modern movements, The Art of Living Foundation is the most recent one, and one of the most active today. Founded in 1982 (...) by Sri Sri Ravi Shankar who is believed by his followers to be the embodiment of divine love, The Art of Living Foundation claims to possess the “keys” to a better living. Indeed, Sri Sri Ravi Shankar's movement offers courses of yoga and meditation worldwide to share its precious wisdom with the widest public, regardless of walks of life, religions, societies and cultures of the aspirants. Sri Sri Ravi Shankar's yoga techniques and main messages as “Life is sacred ; celebrate life” attract an ever-growing public, be it in India, in America, or anywhere else. In spite of the fact that The Art of Living Foundation is present all over the world, Sri Sri Ravi Shankar and his movement remain not very much known among the scholarly circles, especially outside the Indian subcontinent. So, the present study, based on observation and analysis of the movement, will introduce Sri Sri Ravi Shankar and his movement in a critical way by comparing The Art of Living Foundation with the other modern Hindu bhakti movements, highlighting and critiquing the salient features it tries to enshrine. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Art and SelectionBrian BoydArt Instinct: Beauty, Pleasure, and Human Evolution, by Denis Dutton; 279 pp. New York: Bloomsbury Press, 2009, $25.00. Oxford: Oxford University Press, £16.99.In the interests of full disclosure: Denis Dutton, the author of The Art Instinct: Beauty, Pleasure, and Human Evolution, not only edits this journal but has also published here a number of my essays. We share enthusiasms and aversions, but we also now and (...) again disagree. And we both enjoy spirited discussion, which is why I asked him if I might review his book for this journal. Now can we begin?Ellen Dissanayake, the first to take a modern evolutionary approach to art, in her What Is Art For? (1988), doubts that sexual selection can explain much about art. After all, she notes, men can compete about anything, even about who can pee the highest.1 Denis Dutton, the first philosopher to take a sustained evolutionary approach to the arts, suggests that much in art arises from sexual selection—and he spends a good deal of time discussing and dismissing the kind of philosophy of art that orients itself around the urinal that Marcel Duchamp christened Fountain.Dutton begins by reporting recent research into the universality of human landscape preferences. Although these preferences explain little about art in the round, they vividly demonstrate the link between human emotions and preferences across cultures now and human survival [End Page 204] needs thousands of generations ago. In chapter 2, Dutton shows that although recent philosophers of art have not sought to ground art in human nature, that has been an aim of their predecessors from Aristotle to Hume and Kant.But Dutton really starts with the intuitions that art seems a fundamentally similar pursuit around the world, and that artworks like Duchamp's Fountain or Andy Warhol's Brillo Boxes should not be central to our thinking about art, even if they have been central for prominent philosophers of art like George Dickie and Arthur Danto. Dutton stresses that we can appreciate art across cultures. He did so himself when he lived in India while in the Peace Corps, and, an accomplished pianist, learned the sitar from a student of Ravi Shankar, or later, when he lived by the Sepik River in northern Papua New Guinea to ascertain whether "local criteria for beautiful art agree with what Western aficionados and connoisseurs of Sepik art call beautiful. My conclusion was unequivocal: Sepik standards of beauty closely match the opinions of Western experts, including curators and collectors who enjoy a wide experience with Sepik museum collections but who have never set foot in the country" (p. 11).As this passage makes clear, Dutton is not your average armchair academic analytical aesthetician—thank goodness. Unlike the typical professional philosopher of art, he does not hide behind the porcupine quills of philosophese, good for defense and a certain kind of bristly display but utterly rebarbative. Like that other maverick philosopher, Daniel Dennett, he instead engages with work, the world, and readers outside his discipline.Dutton argues convincingly for the need to focus first on indisputable examples of art rather than on problematic cases, just as discussions of murder should not begin with assisted suicide, abortion or capital punishment (p. 50). One of his best chapters offers a cluster concept of art, a dozen features shared by the most unequivocal art. Doubtful cases will satisfy fewer than the full checklist, but there is no fixed threshold, no necessary and sufficient number of criteria. And no criterion by itself distinguishes art from non-art. Indeed one of the most fascinating aspects of his cluster concept is that, for each criterion, he parenthetically notes examples elsewhere in human life that would satisfy that criterion but that nobody would consider art. Skill and virtuosity, for instance, he insists on as features of the indisputably artful, but he adds also: "High skill is a source of pleasure and admiration in every area of human activity beyond art, perhaps most notably today in sports. [End Page 205] Almost every regularized human activity can be turned competitive in order to emphasize the development and admiration of its technical, skill aspect. Guinness World Records... (shrink)

I argue that moral principles involve the same sort of generalization as ordinary yet elusive generic generalizations in natural language such as ‘Tigers are striped’ or ‘Peppers are spicy’. A notable advantage of the generic view is that it simultaneously allows for pessimism and optimism about the role and status of moral principles in our lives. It provides a new perspective on the nature of moral principles on which principles are not apt for determining the moral status of particular actions (...) while they may be apt, and even fundamental, to our acquisition of moral knowledge. A natural consequence of the view is variation among moral principles, with some regularly warranting exceptions and some appearing arguably exceptionless. I will also argue that this generic conception of moral principles has significant advantages, as a normative model of moral reasoning, over the view of moral principles as defaults advanced in recent years. (shrink)

Sri Aurobindo is one of the most prominent figures in the Indian Philosophy of twentieth century and yet we barely find any mention of his work in the philosophy circles. He has written extensively on metaphysics, aesthetics, and ethics. Sri Aurobindo’s work is all-encompassing and carries marks of a deep yogic insight into both the individual self (with all its parts and their integrated working) and the universe that ultimately shares a relation of identity with the individual in secret. He (...) talks about a world-process that contains evolution qualified with involution. It is one of the most unique features of Sri Aurobindo’s philosophy. He deals with the questions of ignorance also in the most satisfying way. Sri Aurobindo has an integral vision that sees everything in the movement of one and develops the methods and practices of Integral Yoga. In his yogic vision, he not only tries to solve the problems of humanity but also attempts to make a very bold move of transforming the whole earthly existence into a divine existence through one large stride. The epistemological discussion we find in his work is deeply connected with his metaphysics. He articulates the limits and extents of reason and senses and attempts to surpass them. Sri Aurobindo is not an armchair philosopher; he attempts to salvage the human condition by empowering humanity to consciously guide the march of human evolution towards a divine future. The boldness of his vision, the originality of his philosophical work is spectacular. In this paper, I will discuss his World-process, i.e. the evolution qualified with involution. I will also discuss the epistemological foundation of his philosophy, cosmology and integral yoga psychology. For the sake of clarity in understanding, the paper is divided into five major sections starting with an introduction. Integralism is a central idea in Sri Aurobindo’s philosophy and I have tried to do justice with it throughout this paper. In the end, the paper attempts to deals with three main themes—cosmology, integral yoga psychology and integral experience. All these three themes shall bring out—The integral experience of Sri Aurobindo is deeply intertwined with his cosmology and yogic psychology and shall not be seen in isolation. Integral experience of reality is also intertwined and works in tandem with his Integral Yoga. There is a yogic exploration of oneness between the self and world that informs and shapes both his philosophical and yogic endeavors. The rationale behind undertaking this study is to question whether the observations of the physical world from the standpoint of yogic experience could suggest some new theoretical framework for the metaphysical ontology of the world. Taking perspectives from the states of consciousness described by Sri Aurobindo may furnish us with a deeper understanding of the material and metaphysical character of physical categories, such as matter, energy, force, space, and time. This paper however is an introductory overview of Aurobindo’s relevance for cosmology, psychology and integral experience which provides a philosophical framework to reinterpret and arrive at a synthetic metaphysics. (shrink)

A prevailing thought is that generics have a covert modal operator at logical form. I claim that if this is right, the covert generic modality is a weak necessity modal. In this paper, I pr...

Color conveys critical information about the flavor of food and drink by providing clues as to edibility, flavor identity, and flavor intensity. Despite the fact that more than 100 published papers have investigated the influence of color on flavor perception in humans, surprisingly little research has considered how cognitive and contextual constraints may mediate color–flavor interactions. In this review, we argue that the discrepancies demonstrated in previously-published color–flavor studies may, at least in part, reflect differences in the sensory expectations that (...) different people generate as a result of their prior associative experiences. We propose that color–flavor interactions in flavor perception cannot be understood solely in terms of the principles of multisensory integration but that the role of higher-level cognitive factors, such as expectations, must also be considered. (shrink)

Individualized customer information is at the heart of on-line commerce. Using increasing amounts of customer-specific data enhances the success and value of one-to-one on-line marketing; but the extensive gathering and use of data specific to individuals also causes alarm over the loss of digital privacy, setting up a confrontation between e-commerce and society. Governments and nations, particularly in Europe, have reacted with a reliance on sweeping laws governing digital privacy protection while other nations such as the U.S. have generally preferred (...) to allow companies and industry associations to regulate themselves. This tenuous balance is under attack from both sides. In this paper, we set up a framework which incorporates the environmental context, ethical perspectives and firm-specific considerations to help firms develop a strategy for handling digital privacy concerns. (shrink)

Libertarians are an increasingly prominent ideological group in U.S. politics, yet they have been largely unstudied. Across 16 measures in a large web-based sample that included 11,994 self-identified libertarians, we sought to understand the moral and psychological characteristics of self-described libertarians. Based on an intuitionist view of moral judgment, we focused on the underlying affective and cognitive dispositions that accompany this unique worldview. Compared to self-identified liberals and conservatives, libertarians showed 1) stronger endorsement of individual liberty as their foremost guiding (...) principle, and weaker endorsement of all other moral principles; 2) a relatively cerebral as opposed to emotional cognitive style; and 3) lower interdependence and social relatedness. As predicted by intuitionist theories concerning the origins of moral reasoning, libertarian values showed convergent relationships with libertarian emotional dispositions and social preferences. Our findings add to a growing recognition of the role of personality differences in the organization of political attitudes. (shrink)

We developed an on-line intelligent argumentation system which facilitates stakeholders in exchanging dialogues. It provides decision support by capturing stakeholders’ rationale through arguments. As part of the argumentation process, stakeholders tend to both polarise their opinions and form polarisation groups. The challenging issue of assessing argumentation polarisation had not been addressed in argumentation systems until recently. Arvapally, Liu, and Jiang [, ‘Identification of Faction Groups and Leaders in Web-Based Intelligent Argumentation System for Collaborative Decision Support’, in Proceedings of International Conference (...) on Collaborative Technologies and Systems] earlier developed a method to identify polarisation groups. These groups, however, tend to overlap to a certain degree; each stakeholder may be a member of multiple polarisation groups to varied degrees. Quantifying stakeholders’ membership in multiple polarisation groups is an important issue in the argumentation for collaborative decision-making, which is not addressed earlier. We present a novel approach using fuzzy clustering algorithm to address this issue in this article. The method is evaluated using data sets produced from the discussions of 24 stakeholders. Experimental results indicate that our method is effective for both identifying polarisation groups and quantifying stakeholders’ degree of membership in each polarisation group. (shrink)

The spread of digital technology to all parts of our lives has led to meaningful benefits, ranging from the conveniences offered by ride-sharing apps to prediction of mental health crises and track...

The hidden brain has its finger on the scale when we make all of our most complex and important decisions – it decides who we fall in love with, whether we should convict someone of murder, or which way to run when someone yells “fire ...

Reflection Principles are commonly thought to produce only strong axioms of infinity consistent with V = L. It would be desirable to have some notion of strong reflection to remedy this, and we have proposed Global Reflection Principles based on a somewhat Cantorian view of the universe. Such principles justify the kind of cardinals needed for, inter alia , Woodin’s Ω-Logic.

The “class play” is an annual tradition in residency training programs and medical schools that celebrates the end of the academic year. It is also a locally generated narrative that reveals important components of an institution’s values, culture, and group dynamics. Exploring the class play is a reflexive exercise that allows one to reflect on his or her professional development and place in the department in a structural, historical, and experience-near driven way. In this way, the creation of and examining (...) of the class play may be seen as an opportunity to understand and expand upon medicine’s Hidden Curriculum. (shrink)

The attitude that ordinary language description of experience is in fact a description of the world is called “naïve realism.” There is an entire branch of modern Western philosophy that is devoted to critically examining the assumptions behind the everyday language we use to describe the macroscopic world in which we live and the validity of naïve realism as an adequate description of the world. This branch of philosophy is called “ordinary language philosophy.” Surprisingly, it has something in common with (...) quantum physics: insight into the inadequacy of ordinary language to describe observable reality. It is this connection between ordinary language philosophy and quantum physics that we shall explore in this article. In the process, we shall also offer a basic introduction to both basic philosophy and basic quantum theory. (shrink)

Evolutionary fitness threats and rewards are associated with subjectively unpleasant and pleasant sensations, respectively. Initially, these correlations appear explainable via adaptation by natural selection. But here I analyse the major metaphysical perspectives on consciousness – physicalism, dualism, and panpsychism – and conclude that none help to understand the adaptive-seeming correlations via adaptation. I also argue that a recently proposed explanation, the phenomenal powers view, has major problems that mean it cannot explain the adaptive-seeming correlations via adaptation either. So the mystery (...) – call it the evolutionary paradox of consciousness – remains. Some have used this mystery to argue for non-naturalistic (e.g. theistic) explanations. But I propose a naturalistic, non-adaptive explanation of the adaptive-seeming correlations: namely, ‘sensational associative learning’ during development. In this perspective, pairing of particular sensations with unconditioned stimuli – fitness rewards or threats – cause the sensations themselves to come to be interpreted as good or bad, respectively. Sensations, like colours, that are not reliably paired with either fitness rewards or threats remain largely unvalenced. Sensational associative learning also provides explanations for adaptive-seeming structural aspects of sensations, such as the observation that sounds of different pitch are experienced as ordinal in correspondence to their wavelengths while the same is not true of colours of different hue. The sensational associative learning perspective appears compatible with physicalism, panpsychism, and dualism (though not epiphenomenalism). (shrink)