A diverse family of proteins has been discovered with a small C‐terminal KASH domain in common. KASH domain proteins are localized uniquely to the outer nuclear envelope, enabling their cytoplasmic extensions to tether the nucleus to actin filaments or microtubules. KASH domains are targeted to the outer nuclear envelope by SUN domains of inner nuclear envelope proteins. Several KASH protein genes were discovered as mutant alleles in model organisms with defects in developmentally regulated nuclear positioning. Recently, KASH‐less isoforms have been (...) found that connect the cytoskeleton to organelles other than the nucleus. A widened view of these proteins is now emerging, where KASH proteins and their KASH‐less counterparts are cargo‐specific adaptors that not only link organelles to the cytoskeleton but also regulate developmentally specific organelle movements. BioEssays 27:1136–1146, 2005. © 2005 Wiley Periodicals, Inc. (shrink)

In this paper, I argue that explanations just ARE those sorts of things that, under the right circumstances and in the right sort of way, bring about understanding. This raises the question of why such a seemingly simple account of explanation, if correct, would not have been identified and agreed upon decades ago. The answer is that only recently has it been made possible to analyze explanation in terms of understanding without the risk of collapsing both to merely phenomenological states. (...) For the most part, theories of explanation were for 50 years held hostage to the historical accident that they far outstripped in sophistication corresponding accounts of understanding. (shrink)

Mechanistic explanation has an impressive track record of advancing our understanding of complex, hierarchically organized physical systems, particularly biological and neural systems. But not every complex system can be understood mechanistically. Psychological capacities are often understood by providing cognitive models of the systems that underlie them. I argue that these models, while superficially similar to mechanistic models, in fact have a substantially more complex relation to the real underlying system. They are typically constructed using a range of techniques for abstracting (...) the functional properties of the system, which may not coincide with its mechanistic organization. I describe these techniques and show that despite being non-mechanistic, these cognitive models can satisfy the normative constraints on good explanations. (shrink)

This paper focuses on two questions: Is understanding intimately bound up with accurately representing the world? Is understanding intimately bound up with downstream abilities? We will argue that the answer to both these questions is “yes”, and for the same reason-both accuracy and ability are important elements of orthogonal evaluative criteria along which understanding can be assessed. More precisely, we will argue that representational-accuracy and intelligibility are good-making features of a state of understanding. Interestingly, both evaluative claims have been defended (...) by philosophers in the literature on understanding as the criterion of evaluation. We argue that proponents of both approaches have important insights and that, drawing on both their own observations and a few novel arguments, we can construct a more complete picture of understanding evaluation. We thus posit the theory of there being Multiple Understanding Dimensions. The main thing to note about our dualism regarding the evaluative criteria of understanding is that it accounts for the intuitions about cases underlying both previously held positions. (shrink)

Concept empiricists are committed to the claim that the vehicles of thought are re-activated perceptual representations. Evidence for empiricism comes from a range of neuroscientific studies showing that perceptual regions of the brain are employed during cognitive tasks such as categorization and inference. I examine the extant neuroscientific evidence and argue that it falls short of establishing this core empiricist claim. During conceptual tasks, the causal structure of the brain produces widespread activity in both perceptual and non-perceptual systems. I lay (...) out several conditions on what is required for a neural state to be a realizer of the functional role played by concepts, and argue that no subset of this activity can be singled out as the unique neural vehicle of conceptual thought. Finally, I suggest that, while the strongest form of empiricism is probably false, the evidence is consistent with several weaker forms of empiricism. (shrink)

Analytic Philosophy, Volume 62, Issue 1, Page 33-56, March 2021.

In recent years, the ontological argument and theistic metaphysics have been criticised by philosophers working in both the analytic and continental traditions. Responses to these criticisms have primarily come from philosophers who make use of the traditional, and problematic, concept of God. In this volume, Daniel A. Dombrowski defends the ontological argument against its contemporary critics, but he does so by using a neoclassical or process concept of God, thereby strengthening the case for a contemporary theistic metaphysics. Relying on (...) the thought of Charles Hartshorne, he builds on Hartshorne's crucial distinction between divine existence and divine actuality, which enables neoclassical defenders of the ontological argument to avoid the familiar criticism that the argument moves illegitimately from an abstract concept to concrete reality. His argument, thus, avoids the problems inherent in the traditional concept of God as static. (shrink)

The rise of China, along with problems of governance in democratic countries, has reinvigorated the theory of political meritocracy. But what is the theory of political meritocracy and how can it set standards for evaluating political progress? To help answer these questions, this volume gathers a series of commissioned research papers from an interdisciplinary group of leading philosophers, historians and social scientists. The result is the first book in decades to examine the rise of political meritocracy and what it will (...) mean for political developments in China and the rest of the world. Despite its limitations, meritocracy has contributed much to human flourishing in East Asia and beyond and will continue to do so in the future. This book is essential reading for those who wish to further the debate and perhaps even help to implement desirable forms of political change. (shrink)

Traditionally, the language faculty was supposed to be a device that maps linguistic inputs to semantic or conceptual representations. These representations themselves were supposed to be distinct from the representations manipulated by the hearer’s perceptual and motor systems. Recently this view of language has been challenged by advocates of embodied cognition. Drawing on empirical studies of linguistic comprehension, they have proposed that the language faculty reuses the very representations and processes deployed in perceiving and acting. I review some of the (...) evidence and arguments in favor of the embodied view of language comprehension, and argue that none of it is conclusive. Moreover, the embodied view itself blurs two important distinctions: first, the distinction between linguistic comprehension and its typical consequences; and second, the distinction between representational content and vehicles. Given that these distinctions are well-motivated, we have good reason to reject the embodied view of linguistic understanding.Keywords: Language; Comprehension; Perception; Action; Embodied cognition; Representation. (shrink)

This paper has both theoretical and practical ambitions. The theoretical ambitions are to explore what would constitute both effective and ethical treatment of Autism Spectrum Disorder.1 However, the practical ambition is perhaps more important: we argue that a dominant form of Applied Behavior Analysis, which is widely taken to be far-and-away the best “treatment”2 for ASD, manifests systematic violations of the fundamental tenets of bioethics. Moreover, the supposed benefits of the treatment not only fail to mitigate these violations, but they (...) often exacerbate them. Warnings of the perils of ABA are not original to us—autism advocates have been ringing this... (shrink)

Argues for political liberalism as a process-oriented view and process philosophy as a politically liberal view Daniel A. Dombrowski brings together the thought of the 20th-century philosophy's greatest political liberal, John Rawls, with the thought of the great process philosophers, Alfred North Whitehead and Charles Hartshorne. He shows that political liberalism is intimately linked with process philosophy, renaming it 'process liberalism'. He justifies this process liberalism in contrast to four potentially troublesome sources or influences: metaphysics, religion, right-wing politics and (...) left-wing politics. Dombrowski engages a series of interlocutors and alternative positions including Franklin I. Gamwell, Timothy D. Snyder, Martin Heidegger and Karl Marx. In conclusion, he offers a compelling, intricate and resourceful argument for nonhuman animal rights based on Rawlsian principles, which in turn forms the basis of a future environmental ethics. (shrink)

Certain of our concepts are innate, but many others are learned. Despite the plausibility of this claim, some have argued that the very idea of concept learning is incoherent. I present a conception of learning that sidesteps the arguments against the possibility of concept learning, and sketch several mechanisms that result in the generation of new primitive concepts. Given the rational considerations that motivate their deployment, I argue that these deserve to be called learning mechanisms. I conclude by replying to (...) the objections that these mechanisms cannot produce genuinely new content and cannot be part of genuinely cognitive explanations. (shrink)

As a strategy for exploring the relationship between understanding and knowledge, we consider whether epistemic luck – which is typically thought to undermine knowledge – undermines understanding. Questions about the etiology of understanding have also been at the heart of recent theoretical debates within epistemology. Kvanvig (2003) put forward the argument that there could be lucky understanding and produced an example that he deemed persuasive. Grimm (2006) responded with a case that, he argued, demonstrated that there could not be lucky (...) understanding. In this paper, we empirically examine how participants' patterns of understanding attributions line up with the predictions of Kvanvig and Grimm. We argue that the data challenge Kvanvig's position. People do not differentiate between knowing-why and understanding-why on the basis of proper etiology: attributions of knowledge and understanding involve comparable (and minimal) roles for epistemic luck. We thus posit that folk knowledge and understanding are etiologically symmetrical. (shrink)

Claims pertaining to understanding are made in a variety of contexts and ways. As a result, few in the philosophical literature have made an attempt to precisely characterize the state that is y understanding x. This paper builds an account that does just that. The account is motivated by two main observations. First, understanding x is somehow related to being able to manipulate x. Second, understanding is a mental phenomenon, and so what manipulations are required to be an understander must (...) only be mental manipulations. Combining these two insights, the paper builds an account (URM) of understanding as a certain representational capacity—specifically, understanding x involves possessing a representation of x that could be manipulated in useful ways. By tying understanding to representation, the account correctly identifies that understanding is a fundamentally cognitive achievement. However, by also demanding that which representations count as understanding-conferring be determined by their practical effects, URM captures the insight that understanding is vitally connected to practice. URM is fully general, and can apply equally well to understanding states of affairs, understanding events, and even understanding people and works of art. The ultimate test of URM is its applicability in actual scientific and philosophical discourse. To that end the paper discusses the importance of understanding in the philosophy of science, psychology, and computer science. (shrink)

Is liberal democracy a universal ideal? Proponents of "Asian values" argue that it is a distinctive product of the Western experience and that Western powers shouldn't try to push human rights and democracy onto Asian states. Liberal democrats in the West typically counter by questioning the motives of Asian critics, arguing that Asian leaders are merely trying to rationalize human-rights violations and authoritarian rule. In this book--written as a dialogue between an American democrat named Demo and three East Asian critics-- (...) class='Hi'>Daniel A. Bell attempts to chart a middle ground between the extremes of the international debate on human rights and democracy.Bell criticizes the use of "Asian values" to justify oppression, but also draws on East Asian cultural traditions and contributions by contemporary intellectuals in East Asia to identify some powerful challenges to Western-style liberal democracy. In the first part of the book, Bell makes use of colorful stories and examples to show that there is a need to take into account East Asian perspectives on human rights and democracy. The second part--a fictitious dialogue between Demo and Asian senior statesman Lee Kuan Yew--examines the pros and cons of implementing Western-style democracy in Singapore. The third part of the book is an argument for an as-yet-unrealized Confucian political institution that justifiably differs from Western-style liberal democracy.This is a thought-provoking defense of distinctively East Asian challenges to Western-style liberal democracy that will stimulate interest and debate among students of political theory, Asian studies, and international human rights. (shrink)

The Singer-Regan debate -- Reciprocity -- Frey's challenge -- The criticisms of Leahy and Carruthers -- The great ape project and slavery -- The Nozick-Rachels debate.

Machery denies the traditional view that concepts are constituents of thoughts, and he more provocatively argues that concepts should be eliminated from our best psychological taxonomy. I argue that the constituency view has much to recommend it (and is presupposed by much of his own theory), and that the evidence gives us grounds for pluralism, rather than eliminativism, about concepts.

Four experiments investigate the folk concept of “understanding,” in particular when and why it is deployed differently from the concept of knowledge. We argue for the positions that people have higher demands with respect to explanatory depth when it comes to attributing understanding, and that this is true, in part, because understanding attributions play a functional role in identifying experts who should be heeded with respect to the general field in question. These claims are supported by our findings that people (...) differentially withhold attributions of understanding when the object of attribution has minimal explanatory information. We also show that this tendency significantly correlates with people’s willingness to defer to others as potential experts. This work bears on a pressing issue in epistemology concerning the place and value of understanding. Our results also provide reason against positing a simple equation of knowledge and understanding. We contend that, because deference plays a crucial role in many aspects of everyday reasoning, the fact that we use understanding attributions to demarcate experts reveals a potential mechanism for achieving our epistemic aims in many domains. (shrink)

Employs the political philosophy of John Rawls to address controversies involving politics and religion.

What is understanding? My goal in this paper is to lay out a new approach to this question and clarify how that approach deals with certain issues. The claim is that understanding is a matter of compressing information about the understood so that it can be mentally useful. On this account, understanding amounts to having a representational kernel and the ability to use it to generate the information one needs regarding the target phenomenon. I argue that this ambitious new account (...) can accommodate much of the data that has motivated theories of understanding in philosophy of science, and can also be generally applicable in epistemology and daily life as well. (shrink)

The generally agreed upon principle that legality and ethics can come apart is frequently overlooked in our professional ethics education and decision-making procedures. The crux of the issue is that we teach in our philosophy classes that the law can sometimes be unethical, but then clearly state in nursing codes of ethics that students should always follow the law. The law could no doubt give us some reason to choose action A over action B, but in professional contexts we frequently (...) treat the law as a side-constraint that limits the logical space of choices to exclude even consideration of action B. If B is the mandatory action, this in effect forces professionals to do something unethical by preventing them from ever seeing the ethical action as an option. This is a problem. Ultimately we concede that there might be an irresolvable tension in competing normative interests in ethics and the law, though we suggest that a more nuanced approach to ethical code formation could help alleviate the issue somewhat. (shrink)

Ethics in the philosophical traditions of India -- Chinese ethics -- Ancient Greek ethics -- Medieval Christian, Jewish, and Islamic ethics -- Ethics in modern philosophy -- African ethics -- The self in Indian philosophy -- The self in Chinese Buddhism -- Ancient Greek philosophy of mind -- Mind and body in early modern philosophy -- African philosophy of mind -- Indian theories of knowledge -- Chinese theories of knowledge.

In recent decades, attempts to explain autism have been frustrated by the heterogeneous nature of its behavioral symptoms and the underlying genetic, neural, and cognitive mechanisms that produce them. This has led some to propose eliminating the category altogether. The eliminativist inference relies on a conception of psychiatric categories as kinds defined by their underlying mechanistic structure. I review the evidence for eliminativism and propose an alternative model of the family of autisms. On this account, autism is a network category (...) defined by a set of idealized exemplars linked by multiple levels of theoretically significant properties. I argue that this network model better captures the empirical phenomena, the historical growth of the category, and the ways the category has been shaped by social norms and interests. Finally, I defend a realist interpretation of network categories against the challenge from eliminativists. (shrink)

In this paper, we explore the link between understanding and transformative decisions. Paul (2014) suggests that one important aspect of making some decisions is that we make them not just on the basis of what data from other people tell us, but based on our own acquaintance with how the decision affects us. In this paper, we draw out a parallel between the sort of reasoning that Paul argues is required for authentic decision making and the sort of epistemic grasp (...) of a subject matter that is required for understanding. The central claim of this paper is that one’s ability to make a decision authentically is proportional to one’s ability to model what it is like to have the possible resultant experience. We endorse a broad notion according to which one can model something by thinking about relevantly similar things. (shrink)

his volume investigates Proclus' own thought and his wide-ranging influence within late Neoplatonic, Alexandrine and Byzantinian philosophy and theology. It further explores how Procline metaphysics and doctrines of causality influence and transition into Arabic and Islamic thought, up until Richard Hooker in England, Spinoza in Holland and Pico in Italy. John Dillon provides a helpful overview of Proclus' thought, Harold Tarrant discusses Proclus' influence within Alexandrian philosophy and Tzvi Langermann presents ground breaking work on the Jewish reception of Proclus, focusing (...) on the work of Joseph Solomon Delmedigo (1591-1655), while Stephen Gersh presents a comprehensive synopsis of Proclus' reception throughout Christendom. The volume also presents works from notable scholars like Helen Lang, Sarah Wear and Crystal Addey and has a considerable strength in its presentation of Pseudo-Dionysius, Proclus' transmission and development in Arabic philosophy and the problem of the eternity of the world. It will be important for anyone interested in the development and transition of ideas from the late ancient world onwards. (shrink)

Defenders of the extended mind thesis say that it is possible that some of our mental states may be constituted, in part, by states of the extra-bodily environment. Often they also add that such extended mentation is a commonplace phenomenon. I argue that extended mentation, while not impossible, is either nonexistent or far from widespread. Genuine beliefs as they occur in normal biologically embodied systems are informationally integrated with each other, and sensitive to changes in the person.

In this article we focus on three key precepts shared by Confucianism and the African ethic of Ubuntu: the central value of community, the desirability of ethical partiality, and the idea that we tend to become morally better as we grow older. For each of these broad similarities, there are key differences underlying them, and we discuss those as well as speculate about the reasons for them. Our aim is not to take sides, but we do suggest ways that Ubuntu (...) and Confucianism might have something to learn from each other and perhaps come closer. We hope that our preliminary reflections can inspire further debate and thinking on a theme – dialogues between long-standing and large-scale non-Western traditions – that is bound to increase in importance as non-Western societies play a greater role in the global system and as the search continues for a 'global ethic'. (shrink)

Neuroscientists have in recent years turned to building models that aim to generate predictions rather than explanations. This “predictive turn” has swept across domains including law, marketing, and neuropsychiatry. Yet the norms of prediction remain undertheorized relative to those of explanation. I examine two styles of predictive modeling and show how they exemplify the normative dynamics at work in prediction. I propose an account of how predictive models, conceived of as technological devices for aiding decision-making, can come to be adequate (...) for purposes that are defined by both their guiding research questions and their larger social context of application. (shrink)

In this paper, we argue that, contra Strevens (2013), understanding in the sciences is sometimes partially constituted by the possession of abilities; hence, it is not (in such cases) exhausted by the understander’s bearing a particular psychological or epistemic relationship to some set of structured propositions. Specifically, the case will be made that one does not really understand why a modeled phenomenon occurred unless one has the ability to actually work through (meaning run and grasp at each step) a model (...) simulation of the underlying dynamic. (shrink)

The view that special science properties are multiply realizable has been attacked in recent years by Shapiro, Bechtel and Mundale, Polger, and others. Focusing on psychological and neuroscientific properties, I argue that these attacks are unsuccessful. By drawing on interspecies physiological comparisons I show that diverse physical mechanisms can converge on common functional properties at multiple levels. This is illustrated with examples from the psychophysics and neuroscience of early vision. This convergence is compatible with the existence of general constraints on (...) the evolution of cognitive systems, and does not involve any ad hoc typing of coarse-grained higher level properties. The mechanisms that realize these common higher level properties are really distinct by the criteria laid down by critics of multiple readability. Finally, I present an account of how such functional properties might constitute special science kinds by playing a central explanatory role in a range of cognitive models. Behavioral science kinds in particular are the functionally defined constituents picked out by our most successful models of the multilevel systems and mechanisms that explain cognitive capacities. (shrink)

Is liberal democracy appropriate for East Asia? In this provocative book, Daniel Bell argues for morally legitimate alternatives to Western-style liberal democracy in the region. Beyond Liberal Democracy, which continues the author's influential earlier work, is divided into three parts that correspond to the three main hallmarks of liberal democracy--human rights, democracy, and capitalism. These features have been modified substantially during their transmission to East Asian societies that have been shaped by nonliberal practices and values. Bell points to the (...) dangers of implementing Western-style models and proposes alternative justifications and practices that may be more appropriate for East Asian societies. If human rights, democracy, and capitalism are to take root and produce beneficial outcomes in East Asia, Bell argues, they must be adjusted to contemporary East Asian political and economic realities and to the values of nonliberal East Asian political traditions such as Confucianism and Legalism. Local knowledge is therefore essential for realistic and morally informed contributions to debates on political reform in the region, as well as for mutual learning and enrichment of political theories. Beyond Liberal Democracy is indispensable reading for students and scholars of political theory, Asian studies, and human rights, as well as anyone concerned about China's political and economic future and how Western governments and organizations should engage with China. (shrink)

Daniel Heller contends that public education is in a downward spiral because we have failed to notice the erosion of the basic curricular dimensions which support the preparation of students as active participants in our ever-changing world. While many books explain procedural knowledge such as how to differentiate instruction, how to create standards-based curriculum, or how to write a constructivist lesson, the second edition of Curriculum on the Edge of Survival discusses the "what" and "why" rather than the how. (...) What is the purpose of schools in a free, democratic society, and why is the answer to that question crucial in deciding the most fundamental questions about curriculum? (shrink)

The ancient background -- Weiss and the pursuit of bodily excellence -- Huizinga and the homo ludens hypothesis -- Feezell, moderation, and irony -- The process of becoming virtuous.

Natural kind concepts have the function of tracking categories that exist independently of our beliefs and purposes. But not all ways of tracking categories in the natural world involve conceiving of them as natural kinds. Anthropic concepts represent groups of natural, mind‐independent entities that are apt for serving various human interests, goals, and projects. They represent the natural world under a practical mode of presentation, as a set of material resources that can be transformed to further a host of functions (...) and ends. I argue that cross‐cultural studies of traditional ecological knowledge provide evidence that many chemical, mineral, and biological concepts that are frequently taken to be natural kind concepts turn out on closer inspection to be anthropic concepts. Anthropic concepts are distinguished from artifact concepts, and a form of realism about the anthropic kinds that they refer to is defended. (shrink)

Daniel Heller contends that public education is in a downward spiral because we have failed to notice the erosion of the basic curricular dimensions which support the preparation of students as active participants in our ever-changing world. While many books explain procedural knowledge such as how to differentiate instruction, how to create standards-based curriculum, or how to write a constructivist lesson—Curriculum on the Edge of Survival discusses the "what" and "why" rather than the how. What is the purpose of (...) schools in a free, democratic society, and why is the answer to that question crucial in deciding the most fundamental questions about curriculum? (shrink)

In this paper, I explore the possibility that the point Kripke (1982) made about understanding meaning also applies to understanding social interaction. This understanding involves extending what one has learned from a finite number of past observations to provide normative guidance for an indefinitely complicated future. Kripke argues (to my mind correctly) that what one should do in the future is inevitably underdetermined by the infinite possible interpretations of the past. Moreover, no matter how much one attempts to make the (...) rules explicit, they will always be underspecified. I then explore the speculative hypothesis that having different tacit dispositions made manifest in one’s understanding of the rules of social engagement would look remarkably similar to tendencies exhibited by many autistic individuals. The analogy will say something substantive about how neurotypicals (and other autists) should treat the behavior of autistic individuals—if we are not even doing anything incorrect, then society should not be criticizing our means of engagement. (shrink)

Conceptual atomists argue that most of our concepts are primitive. I take up three arguments that have been thought to support atomism and show that they are inconclusive. The evidence that allegedly backs atomism is equally compatible with a localist position on which concepts are structured representations with complex semantic content. I lay out such a localist position and argue that the appropriate position for a non-atomist to adopt is a pluralist view of conceptual structure. I show several ways in (...) which conceptual pluralism provides an advantage in satisfying the empirical and philosophical demands on a theory of conceptual structure and content. (shrink)

A ‘Radical Simulationist’ account of how folk psychology functions has been developed by Robert Gordon. I argue that Radical Simulationism is false. In its simplest form it is not sufficient to explain our attribution of mental states to subjects whose desires and preferences differ from our own. Modifying the theory to capture these attributions invariably generates innumerable other false attributions. Further, the theory predicts that deficits in mentalizing ought to co-occur with certain deficits in imagining perceptually-based scenarios. I present evidence (...) suggesting that this prediction is false, and outline further possible empirical tests of the theory. (shrink)

This tightly argued, historically grounded study sets out to demonstrate that a 'pro-choice' stance is as fully justified by Catholic thought as an anti-abortion view, and may even be more compatible with Catholic tradition than the current opposition to abortion espoused by most Catholic leaders.

This book provides an approach to Emerson that walks the line between traditional and revisionist interpretations of his life and works. The author presents Emerson as a man of faith whose unique synthesis of Kantian and Vedantic philosophies resulted in a view of faith that was one hundred years ahead of its time.

This work has been selected by scholars as being culturally important and is part of the knowledge base of civilization as we know it. This work is in the public domain in the United States of America, and possibly other nations. Within the United States, you may freely copy and distribute this work, as no entity (individual or corporate) has a copyright on the body of the work. Scholars believe, and we concur, that this work is important enough to be (...) preserved, reproduced, and made generally available to the public. To ensure a quality reading experience, this work has been proofread and republished using a format that seamlessly blends the original graphical elements with text in an easy-to-read typeface. We appreciate your support of the preservation process, and thank you for being an important part of keeping this knowledge alive and relevant. (shrink)