Empirical bioethics is commonly understood as integrating empirical research with normative-ethical research in order to address an ethical issue. Methodological analyses in empirical bioethics mainly focus on the integration of socio-empirical sciences and normative ethics. But while there are numerous multidisciplinary research projects combining life sciences and normative ethics, there is few explicit methodological reflection on how to integrate both fields, or about the goals and rationales of such interdisciplinary cooperation. In this paper we will review some drivers for (...) the tendency of empirical bioethics methodologies to focus on the collaboration of normative ethics with particularly social sciences. Subsequently, we argue that the ends of empirical bioethics, not the empirical methods, are decisive for the question of which empirical disciplines can contribute to empirical bioethics in a meaningful way. Using already existing types of research integration as a springboard, five possible types of research which encompass life sciences and normative analysis will illustrate how such cooperation can be conceptualized from a methodological perspective within empirical bioethics. We will conclude with a reflection on the limitations and challenges of empirical bioethics research that integrates life sciences. (shrink)

This paper draws upon both Carl Jung’s theory of the psyche and nonviolence philosophy to re-examine curriculum dynamics in the context of teacher education. An integrative psychic life is enabled by the transcendent function of assimilating the unconscious to expand the horizon of consciousness while the integrative power of nonviolence heals the wounds of violence and promotes compassionate relationships. These theories follow different directions—the primary focus of Jung’s theory is the individual person and that of nonviolence theory is humane (...) relationality—but their underlying philosophical principles also intersect in ways that have important implications for today’s education. This paper focuses on three major intersections: the thread of interconnectedness is the undercurrent of an integrative psychic life and the underlying foundation for nonviolent relations; the shadow awareness within the individual psyche creates a social space for compassionate relationships with others; and complementary modes of psychic and nonviolent integration provide multiple pathways for teacher educators’ pedagogy and students’ self-education. After elaborating on these intersecting aspects and their curriculum implications, the final section discusses curriculum dynamics for subjective and social transformation through analysing the interactive relationships between and among teacher educators, students, texts, and contexts. (shrink)

This paper argues that research on normative issues in the life sciences will benefit from a tighter integration of philosophy of science. We examine research on ethical, legal and social issues in the life sciences (“ELSI”) and discuss three illustrative examples of normative issues that arise in different areas of the life sciences. These examples show that important normative questions are highly dependent on epistemic issues which so far have not been addressed sufficiently in ELSI, RRI and (...) related areas of research. Accordingly, we argue for the integration of research on the epistemic aspects of the relevant areas of science into ELSI research to provide a better basis for addressing normative questions. (shrink)

Shows that executive integrity is not merely a moral trait but a dynamic process of making empathetic, responsible, and sound decisions. Describes key features of executive integrity including effective social interaction, open dialogue, and responsive leadershipand explains how integrity can be developed and practiced in today's organizations.

In the chapter about the religion of art Hegel differentiates between four ways of integrating the Absolute: 1. integration though statues of gods, 2. integration through language, 3. integration through a religious cult, mysteries and festivities, 4. integration through the higher language of tragedy. Integration is conducted by the artist – the spirit is an artist. Still, it was demonstrated that these attempts of integration fail. Only one using speculative philosophy can succeed where the artist cannot: unity with the Absolute. (...) Integration, which was presented by Hegel in the Phenomenology of Spirit, and translated through different forms of the religion of art and the appropriation of the Absolute, leads to a point where the Absolute vanishes: at first the man uses it as a “cleaner, a house and in the feast of its victim“. Then, the inner being of the Absolute is consummated “in the mystery of bread of wine” and, finally, annihilated in the laughter of a comedy. The artist, an integrator of the Absolute in the life of the people, is at last so successful that the relationship is reversed: it is, finally, the true selfness, which rises as the master over the Absolute. The integration of the Absolute fails due to the hypocrisy of the artist’s work. The road the artist walks on, prepares the ground for uncovering an obvious religion and, thus, indirectly, for an appearance of speculative philosophy. (shrink)

Much is being written these days about integration, its desirability and even its necessity when complex research problems are to be addressed. Seldom, however, do we hear much about the failure of such efforts. Because integration is an ongoing activity rather than a final achievement, and because today’s literature about integration consists mostly of manifesto statements rather than precise descriptions, an examination of unsuccessful integration could be illuminating to understand better how it works. This paper will examine the case of (...) prokaryote phylogeny and its apparent failure to achieve integration within broader tree-of-life accounts of evolutionary history. Despite the fact that integrated databases exist of molecules pertinent to the phylogenetic reconstruction of all lineages of life, and even though the same methods can be used to construct phylogenies wherever the organisms fall on the tree of life, prokaryote phylogeny remains at best only partly integrated within tree-of-life efforts. I will examine why integration does not occur, compare it with integrative practices in animal and other eukaryote phylogeny, and reflect on whether there might be different expectations of what integration should achieve. Finally, I will draw some general conclusions about integration and its function as a ‘meta-heuristic’ in the normative commitments guiding scientific practice. (shrink)

To determine when the life of a human organism begins, Mark T. Brown has developed the somatic integration definition of life. Derived from diagnostic criteria for human death, Brown’s account requires the presence of a life‐regulation internal control system for an entity to be considered a living organism. According to Brown, the earliest point at which a developing human could satisfy this requirement is at the beginning of the fetal stage, and so the embryo is not regarded (...) as a living human organism. This, Brown claims, has significant bioethical implications for both abortion and embryo experimentation. Here, we dispute the cogency of Brown’s derivation. Diagnostic criteria for death are used to determine when an organism irreversibly ceases functioning as an integrated whole, and may vary significantly depending on how developed the organism is. Brown’s definition is derived from a specific definition of death applicable to postnatal human beings, which is insufficient for generating a general definition for human organismal life. We have also examined the bioethical implications of Brown’s view, and have concluded that they are not as significant as he believes. Whether the embryo is classified as a human organism is of peripheral interest—a far more morally relevant question is whether the embryo is a biological individual with an identity that is capable of persisting during development. (shrink)

Many people have claimed that integrity requires sticking to one's convictions come what may. Greg Scherkoske challenges this claim, arguing that it creates problems in distinguishing integrity from fanaticism, close-mindedness or mere inertia. Rather, integrity requires sticking to one's convictions to the extent that they are justifiable and likely to be correct. In contrast to traditional views of integrity, Scherkoske contends that it is an epistemic virtue intimately connected to what we know and have reason to believe, rather than an (...) essentially moral virtue connected to our values. He situates integrity in the context of shared cognitive and practical agency and shows that the relationship between integrity and impartial morality is not as antagonistic as many have thought - which has important implications for the 'integrity objection' to impartial moral theories. This original and provocative study will be of great interest to advanced students and scholars of ethics. (shrink)

Three questions motivate this project: How does science come to explain elusive, abstract concepts such as 'life' and 'mind'? From the failure of vitalist theories in the early 20th century, can anything be inferred about modern dualist theories of mind? And can the history of the life sciences provide any positive methodological guidance for approaching the problem of consciousness? ;The sciences of life and mind span many levels of analysis, and thus raise philosophical questions about inter-level explanation (...) and integration. I argue that the usual way of framing such questions is inadequate, and propose an alternative: the Domain Integration model, which places a greater emphasis on the structure and dynamics of scientific inquiry rather than on the relations among scientific theories . I then put the model to use in an extended investigation of historical advances in the sciences of life and mind, with a special focus on the interplay of mechanist and holist research strategies. This investigation is structured by an analogy between vitalism and dualism, and one of its goals is to illustrate the process whereby seemingly insurmountable conceptual barriers to scientific explanation are eventually surmounted. ;Turning to more theoretical issues, I argue that 'reducibility' is an implausible and unuseful standard of inter-level connectivity, and that Domain Integration is better suited to the task of describing the actual structure of evolving, multi-level sciences. In a related analysis I demonstrate that materialism and dualism, traditionally construed as claims about the ultimate structure of reality, become more coherent and useful when reinterpreted as methodological commitments to integrationist or anti-integrationist research strategies. Both positions remain tenable on this reinterpretation, but methodological materialism is substantially easier to justify. Finally, I apply this framework to the problem of consciousness, arguing that the goal of inquiry should be to close the conceptual gap between mental and physical, and that views which urge us to take consciousness as "basic" or "fundamental" are therefore deeply misguided. Drawing again on the historical analogy with biology, I conclude that a methodology of incremental, multifactorial, integrationist explanation of consciousness is possible, desirable---and underway. (shrink)

The is the Editorial of the 2015 JPBMB Special Issue on Integral Biomathics: Life Sciences, Mathematics and Phenomenological Philosophy.

This collection of 30 essays covers living a moral and ethical life as a lawyer and Christian, following the example of J. Reuben Clark, Jr. The mission and history of the BYU Law School is also adressed.

Evolutionary Life History Theory (LHT) is a powerful framework that can be used for understanding behavioral strategies as contingent adaptations to environmental conditions. Del Giudice uses LHT as a foundation for describing the attachment process as an evolved psychological system which evaluates life conditions and chooses reproductive strategies appropriate in the developmental environment, integrating findings across several literatures.

Some provisions of the UN’s Convention on the Elimination of Discrimination Against Women (CEDAW) are clearly important from the perspective of business ethics, particularly those calling for equal rights for women to employment and financial security. Some other provisions of CEDAW are equally as important for ethical business practices and Corporate Social Responsibility (CSR), but are frequently overlooked because of the presumption that they are not strictly business concerns: the rights of women to participation in public life, marriage, and (...) family rights; the rights of rural women to adequate living conditions; and general rights to equality. This chapter will discuss the conceptual commitments that underlie the assumption of a clear demarcation between work and life concerns, and examine the criticisms of this assumption made by feminism. It will, in particular, be interested in: -/- • The public/private distinction • The meaning of “work” or “labor” • The relationship between CSR and care ethics • Fostering a broader understanding of the family or familial relations • Examining the connection between fair wages and work/life integration -/- These discussions suggest that the ability for businesses worldwide to uphold the tenets of CEDAW is dependent upon a reconsideration of the character of the Ideal Worker and a nuanced understanding of the effects of workplace policies on the wider communities in which businesses operate. In particular, though work/life integration is not strictly speaking a “women’s issue,” the ethical and policy considerations addressed herein currently have disproportionately negative effects for women; thus, addressing them is crucial for achieving the aims of gender equality. (shrink)

The theoretical biology movement originating in Britain in the early 1930’s and the biosemiotics movement which took off in Europe in the 1980’s have much in common. They are both committed to replacing the neo-Darwinian synthesis, and they have both invoked theories of signs to this end. Yet, while there has been some mutual appreciation and influence, particularly in the cases of Howard Pattee, René Thom, Kalevi Kull, Anton Markoš and Stuart Kauffman, for the most part, these movements have developed (...) independently of each other. Focussing on morphogenesis understood as vegetative semiosis, in this paper I will argue that the ideas of these movements are commensurate. Furthermore, synthesising them would enable us to see life processes as proto-narratives. Doing so will involve synthesising biohermeneutics, Peircian biosemiotics with Waddington’s theoretical biology and Piagetian genetic structuralism, and this, I claim, would strengthen the challenge of these traditions to mainstream biology. At the same time, this should contribute to overcoming the opposition between the sciences and the humanities, developing a broader tradition of Schellingian thought which involves developing the humanities and then demanding of the physical and biological sciences that they are consistent with and can make intelligible the emergence of humans as conceived by the humanities. (shrink)

본 논문의 목표는 행복한 인간에 대한 견해를 제시하는 것이다. 논자는 자기충실성(integrity)을 가지고 사는 사람이 행복한 인간이라고 주장할 것이다. 논자의 견해에서 자기충실성을 가지는 사람은 특정한 가치나 원리에 헌신되어 외부의 압박이 있을지라도 그 가치나 원리를 포기하지 않는 사람이다. 자기충실성을 가진다는 것이 무엇인가를 제시하기 전에 우선 기존의 행복론에 대한 비판적 논의를 전개한다. 널리 알려졌듯이, 철학 내에서 행복에 관한 세 가지 주요 이론은 쾌락주의, 욕구만족이론, 객관적 명부 이론 등이다. 논자는 이 세 가지 이론들이 나름대로 매력을 지녔지만 충분히 만족스럽지 못하다고 주장한다. 다음으로 자기충실성을 가지고 살아가는 (...) 것이 무엇인가에 대해 설명한다. 논자의 견해에서 자기충실성을 가지기 위해선 세 가지 조건이 필요하다. 첫째, 어떤 가치나 원리에 헌신되는 것이다. 둘째, 자신의 헌신의 대상인 가치나 원리에 따라 행동하는 것이다. 셋째, 열린 태도로 그 헌신을 유지하는 것이다. 자기충실성의 조건을 설명한 후 논자는 가치나 원리에 관한 제한에 대해서 논의한다. 다양한 가치나 원리가 자기충실성을 위한 대상이 될 수 있지만 그렇다고 해서 아무 것이나 다 그 대상이 될 수 있는 것은 아니다. 첫째, 그 가치나 원리는 자신의 진정한 원함에 의해 선택된 것이어야 한다. 둘째, 그 가치나 원리는 삶에 아무런 영향을 끼치지 않을 만큼 하찮아선 안 된다. 셋째, 그 가치나 원리에 따라 행동하는 것이 자기파괴적인 것이 되어선 안 된다. 넷째, 그 가치나 원리는 사악한 것이어선 안 된다. 이 논의 후 논자의 주장에 대한 가능한 반박 및 그에 대한 대응에 대해 논의한다. (shrink)

Background: Meaning in life of older persons is related to well-being, health, quality of life, and “good life.” However, the topic is scarcely covered in nursing literature. Objective: The aim of this integrative review for nurses is to synthesize knowledge from scholarly literature to provide insight into how older persons find meaning in life, what are influencing circumstances, and what are their sources of meaning. The review serves as a starting point for including meaning in (...) class='Hi'>life of older persons as a major concern for nurses in their role as health promoters. Method: An integrative review was performed including empirical research literature and texts on theoretical perspectives. Ethical consideration: Researches agree with ethical codes for research of universities in the Netherlands. For literature reviews no additional procedures are necessary according to Dutch law. Findings: A total of 44 heterogeneous texts were included in this review. Finding meaning in life is challenging for older persons. Older persons find meaning through a developmental process, by creating and discovering. Meaning in life is found in connection with self and others. Health, living together, high socio-economic status, social relations, activities, and religion are associated with experiencing meaning in later life. The main source of meaning in life of older persons is human relationships. Other sources of meaning in life vary by age and culture. Discussion: The review provides insight into meaning in life of older persons. There are several gaps in knowledge: literature is culturally biased, research on discovery of meaning and daily meaning is limited, and research from a nursing perspective is lacking. In practice, nurses have many opportunities to attune to meaning in life of patients. Further development of competence and training are needed. Conclusion: Older persons find meaning in life through different processes. Meaning in life is associated with the circumstances old persons live in. Human relationship is the major source of meaning. The knowledge from this review is a necessary knowledge base for nurses to include meaning in life of older patients in care. Further research is needed to explore the role of nurses. (shrink)

The somatic integration definition of life is familiar from the debate on the determination of death, with some bioethicists arguing that it supports brain death while others argue that some brain‐dead bodies exhibit sufficient somatic integration for biological life. I argue that on either interpretation, the somatic integration definition of life implies that neither the preimplantation embryo nor the postimplantation embryo meet the somatic integration threshold condition for organismal human life. The earliest point at which a (...) somatic integration determination of life could be made would be the beginning of the fetal stage, 9 weeks postfertilization. Bioethical implications are considered, specifically with respect to the moral status of the postimplantation embryo in embryo research and abortion. (shrink)

Learners who are first introduced to the process of critical thinking frequently experience a paradigm shift in their own thinking. However, such a major transition in one’s pattern of thinking may presentdifficulties when applying newly acquired critical thinking skills in social contexts. Learners may lack the confidence required for engaging in intellectual discourse, placing inhibitions on their using critical thinking. This article suggests several ways in which critical thinkers may more effectively and confidently use their skills in daily conversation.

BOOK REVIEW Extract: Integrity, it seems, is a matter of remaining true to oneself, or rather, it is a matter of remaining true to what one reasonably judges to be the best of oneself. In Integrity and the Virtues of Reason, Greg Scherkoske seeks to overturn this piece of conventional wisdom. It is a fine book and I learned a lot from it. Scherkoske elaborates and defends the idea that integrity is an epistemic virtue; that it is not fundamentally a (...) matter of being true to oneself but of being a good and responsible epistemic agent. What is wrong with the conventional picture, Scherkoske thinks, is that it invites moral danger. The moral danger Scherkoske has in mind takes two forms. One is self-indulgence. When faced with demands from others, fidelity to one's own commitments just because they are one's own can easily lead to a promotion of one's own interests over the interests of others. The second danger is blind allegiance. "Even if a person's commitments cannot be construed as self-indulgent or egoistic, an individual's belief that something is a matter of integrity might be taken to foreclose the possibility of challenge and revision". (shrink)

A philosophical exploration of the ideal of intellectual integrity drawing on Samuel Butler's semi-autobiographical Bildungsroaman, The Way of All Flesh; and relating this to C.S. Peirce's idea of the scientific attitude and Percy Bridgman's reflections on the conditions needed for this ideal to flourish.

Life education, also known as life and death education, is an important subject in Taiwan with institutions offering degree programs and courses that focus on quality learning and implementation of life education. What is interesting from the perspective of Taiwanese Education is that the teaching of life education also incorporates a number of Eastern-derived and conceptualized tenets, for example, Buddhist teaching and the importance of spiritual wisdom. This premise contends then that life education in Taiwan, (...) in general, is concerned with the promotion, fulfillment, and cherishing of quality life experiences (e.g., personal contentment, happiness). One example of life education, which resonates with other spiritual beliefs and religious faiths (e.g., Hinduism), is related to spiritual cultivation and the enlightenment of life wisdom. Our own teaching of the subject, likewise, places emphasis on the goal of teaching students to seek meaningful understanding of and appreciation for three major, interrelated components of life education: life wisdom, life practice, and life care. Life education is a beneficial subject as its theoretical understanding may help individuals cope with pathologies and negative life experiences. One negative life experience, in this case, is the ultimate fate of humankind: death. Approaching death and/or the onset of grief is something that we all have to experience. How does one approach death? It is not easy feat and, of course, grief for a loved one is personal and some of us struggle with this. We contend that spiritual cultivation and enlightenment, arising from life education, may assist us with the coping of death (e.g., the possibility of transcendence beyond the realm of life). Forming the premise of the present article, we propose that a person’s ‘spiritual and enlightened self’, reflecting the convergence of three major aspects of life education (i.e., Philosophical reflection, Enrichment of personal well-being, and Spiritual cultivation), would result in the initiation and creation of a number of virtues and positive characteristics – for example: having a positive outlook in life, showing compassion, forgiveness, etc. These virtues and quality characteristics, from our philosophical reasoning, are equivalent to those qualities that positive psychology advocates for. (shrink)

If the practice of maternal‐fetal medicine sometimes results in abortion, can a physician strongly opposed to abortion maintain his own integrity and still practice in this field?

Part biography and part constructive ethical inquiry, this book is an original interpretation of the Scottish philosopher Adam Ferguson’s ethical method and view of ethical integrity, with an emphasis on his Analysis, Institutes, and Principles.

Cellular circadian clocks represent ancient anticipatory systems which co‐evolved with the first cells to safeguard their survival. Cyanobacteria represent one of the most ancient cells, having essentially invented photosynthesis together with redox‐based cellular circadian clocks some 2.7 billion years ago. Bioelectricity phenomena, based on redox homeostasis associated electron transfers in membranes and within protein complexes inserted in excitable membranes, play important roles, not only in the cellular circadian clocks and in anesthetics‐sensitive cellular sentience (awareness of environment), but also in the (...) coupling of single cells into tissues and organs of unitary multicellular organisms. This integration of cellular circadian clocks with cellular basis of sentience is an essential feature of the cognitive CBC‐Clock basis of cellular life. (shrink)

Gallup surveys consistently show that nine in 10 Americans express a belief in God (Nash, Business, religion, and spirituality: A new synthesis, 2003 ), while more than 45 % claim to have some awareness of God on the job (Nash and McLellan, Church on Sunday, Work on Monday: The Challenges of Fusing Christian Values with Business Life, 2001 ). Recently, Lynn et al. (Journal of Business Ethics 85:227–243, 2009 ) argued that the ability to integrate the specific beliefs and (...) practices of one’s faith with the work one does represent an important although neglected area of research. As such, they developed and demonstrated convergent validity for the faith at work scale, designed to measure the extent to which individuals believe they are able to integrate their Judaeo-Christian beliefs and practices and their work. In a subsequent study, Lynn et al. (Human Relations 64:675–701, 2010 ) demonstrated that the faith at work scale was related to faith maturity, church attendance, age, and denominational strictness, and negatively associated with organizational size. No research, however, has examined the possible positive benefits of integrating faith and work. I therefore developed and tested hypotheses concerning the relationship between the faith at work scale and seven important life and work outcomes (satisfaction with life, intent to leave one’s job, self-rated job performance, job satisfaction, and three forms of organizational commitment). In all, four of seven hypotheses were confirmed. (shrink)

This discussion note aims to address the two points which Lizza raises regarding my critique of his paper “Defining Death: Beyond Biology,” namely that I mistakenly attribute a Lockean view to his ‘higher brain death’ position and that, with respect to the ‘brain death’ controversy, both the notions of the organism as a whole and somatic integration are unclear and vague. First, it is known from the writings of constitutionalist scholars that the constitution view of human persons, a theory which (...) Lizza also holds, has its roots in John Locke’s thought. Second, contrary to Lizza’s claims, the notions of the organism as a whole and somatic integration are both more than adequately described in the biomedical and biophilosophical literature. (shrink)

This important volume covers ethics and integrity in health and life sciences research. It addresses concerns in gene editing, dual use and misuse of biotechnologies, big data and nutritional science in health and medicine, and covers attempts at ensuring ethical practices in such fields are shared internationally.

In diesem Aufsatz gibt der Verfasser eine präcisere und vollständigere Darstellung des Inhalts seiner früheren Veröffentlichung über dasselbe Thema. Im Falle eines biologischen Systems, dessen innerer Zustand sich durch ein einziges Parameterc bestimmen lässt, werde seine zeitliche Entwicklung durch die Gleichung dctdt=f1+∫t−λtf2dτ......dargestellt. Es wird gezeigt, dass Differentiation dieser Gleichung nacht nicht zu einer gewöhnlichen Differentialgleichung zweiter Ordnung führt. Im Gegensatz zur Theorie gewöhnlicher Differentialgleichungen, werden die Eigenschaften von Gleichung und ihren Derivaten nach der Zeit diskutiert. Es lässt sich Gleichung auf (...) eine gewöhnliche Differentialgleichung höherer Ordnung reduzieren. nur im ausgeschlossenen Fall, dasst-λ ein bestimmter Zeitpunkt wäre.Wolle man einwenden, dass Gleichung und ihre Derivaten nach der Zeit die zeitliche Entwicklung von Systemen darstellen, die zu jedem Moment nur ein „Punktgedächtnis” besitzen, dann lässt sich das Integralglied leicht derart transformieren, dass keine weitere Differentiation nach der Zeit auf eine Gleichung ohne Integralglied führen kann. Beispiele solcher Transformationen werden gegeben. Die neuen Gleichungen beschreiben die Entwicklung von Systemen die sicher ein „lineäres” Gedächtnis besitzen, d.h. ein Gedächtnis das sich zu jedem Moment auf ein endliches Kontinuum von Zeitpunkten und Zuständen erstreckt.Es ergibt sich aus der vollständigeren Betrachtung, dass Gleichung der früheren Abhandlung einer Revision bedarf.L'auteur fait un examen plus exact et plus approfondi du sujet traité dans sa première publication. Pour le cas d'un système biologique dont l'état intérieur est défini par un seul paramètrec, l'évolution au cours du temps se laisse decrire par l'équation dctdt=f1+∫t−λtf2dτ......Une différentiation d'après le tempst ne peut pas réduire l'équation à une équation différentielle ordinaire. Cela est possible seulement dans le cas exclu quet-λ soit un moment fixé. Au contraste des équations différentielles ordinaires, l'auteur explique comment se différent les propriétés de l'équation et de ses dérivés d'après le temps.Pour éviter la critique que l'équation et ses dérivés d'après le temps décrivent l'évolution de systèmes qui à tout moment donné ne possèdent qu'une „mémoire à une seule valeur”, l'auteur expose comment l'intégrale peut se transformer afin qu'aucune nouvelle différentiation d'après le temps ne conduise à une équation sans intégrale. Plusieurs exemples d'une telle transformation sont donnés. Les équations transformées décrivent sans aucun doute l'évolution de systèmes qui à tout moment possèdent une mémoire qui s'étend sur une intervalle continue du temps passé. L'examen plus approfondi démontre que l'équation de la première publication doit être corrigée. (shrink)

The Continuous Parameter Estimation Model is applied to develop individual genomic-level heritabilities for the latent hierarchical structure and developmental dynamics of Life History (LH) strategy LH strategies relate to the allocations of bioenergetic resources into different domains of fitness. LH has moderate to high population-level heritability in humans, both at the level of the high-order Super-K Factor and the lower-order factors, the K-Factor, Covitality Factor, and General Factor of Personality (GFP). Several important questions remain unexplored. We developed measures of (...) genome-level heritabilities employing an American sample of 316 monozygotic (MZ) and 274 dizygotic (DZ) twin dyads and a Swedish sample of 863 MZ and 475 DZ twin dyads. This novel heritability index measures individual genetic transmissibility, therefore opening new avenues for analyzing complex interactions among heritable traits inaccessible to standard structural equations methods. For these samples: (1) moderate to high heritability of factor loadings of Super-K on its lower-order factors is demonstrated, evidencing biological preparedness, genetic accommodation, and the gene-culture coevolution of biased epigenetic rules of development; (2) moderate to high heritability of the magnitudes of the effect of the higher-order factors upon their loadings on their constituent factors, evidencing genetic constraints upon phenotypic plasticity; and (3) that heritability of the LH factors, of factor loadings, and of the magnitudes of the correlations among factors are weaker among those with slower LH speeds, demonstrating that inter-individual variation in transmissibility is a function of individual socioecological selection pressures. (shrink)

This collection addresses two different audiences: 1) historians and philosophers of the life sciences reflecting on collaborations across disciplines, especially as regards defining and addressing Grand Challenges; 2) researchers and other stakeholders involved in cross-disciplinary collaborations aimed at tackling Grand Challenges in the life and medical sciences. The essays collected here offer ideas and resources both for the study and for the practice of goal-driven cross-disciplinary research in the life and medical sciences. We organise this introduction in (...) three sections. The first section provides some background and context. The second motivates our take on this topic and then outlines the central ideas of each paper. The third section highlights the specificity and significance of this approach by considering: a) how this collection departs from existing literature on inter- and trans-disciplinarity, b) what is characteristic about this approach, and c) what role this suggests for the history and philosophy of the life sciences in addressing Grand Challenges. (shrink)

Just Ecological Integrity presents a collection of revised and expanded essays originating from the international conference "Connecting Environmental Ethics, Ecological Integrity, and Health in the New Millennium" held in San Jose, Costa Rica in June 2000. It is a cooperative venture of the Global Ecological Integrity Project and the Earth Charter Initiative.

Just Ecological Integrity presents a collection of revised and expanded essays originating from the international conference 'Connecting Environmental Ethics, Ecological Integrity, and Health in the New Millennium' held in San Jose, Costa Rica in June 2000. It is a cooperative venture of the Global Ecological Integrity Project and the Earth Charter Initiative.

Performance on abstract unfamiliar tasks used to measure intelligence has not been found to correlate with individual differences in highly skilled and expert performance. Given that cognitive and neural structures and regions mediating performance change as skill increases, the structures highlighted by parieto-frontal integration theory are unlikely to account for individual differences in skilled cognitive achievement in everyday life.

In searching for life in extraterrestrial space, it is essential to act based on an unequivocal definition of life. In the twentieth century, life was defined as cells that self-replicate, metabolize, and are open for mutations, without which genetic information would remain unchangeable, and evolution would be impossible. Current definitions of life derive from statistical mechanics, physics, and chemistry of the twentieth century in which life is considered to function machine like, ignoring a central role (...) of communication. Recent observations show that context-dependent meaningful communication and network formation (and control) are central to all life forms. Evolutionary relevant new nucleotide sequences now appear to have originated from social agents such as viruses, their parasitic relatives, and related RNA networks, not from errors. By applying the known features of natural languages and communication, a new twenty-first century definition of life can be reached in which communicative interactions are central to all processes of life. A new definition of life must integrate the current empirical knowledge about interactions between cells, viruses, and RNA networks to provide a better explanatory power than the twentieth century narrative. (shrink)

Genetic engineering is still considered morally wrong by a large proportion of the public. Yet many scientists are puzzled about the public concern over a technology that, in their view, promises great benefits to humans and does not seem to cause more harm to animals than other practices which are rarely questioned. In this book, Michael Hauskeller takes public fears seriously and offers the idea of 'biological integrity' as a clarifying principle which can then be analyzed to show that seemingly (...) irrational public concerns about genetic engineering are not so irrational and that a philosophically sound justification of those concerns can indeed be given. (shrink)

This integral investigation explored phenomenological and neurophysiologic, individual and collective dimensions of Christian Trinitarian meditation experiences in a volunteer, convenience sample of 10 practicing Christians, 6 men and 4 women, with a mean age of 48 years and an age range from 21 to 85 years. Participants meditated for a minimum period of 15 minutes, during which neurophysiologic data in the form of electroencephalographic (EEG), electromyographic (EMG), blood volume pulse (BVP) and respiratory activity were recorded. A phenomenological analysis indicated (...) that the meditation process generally involved a movement from body to mind to spirit as evident in reports of an increasingly relaxed, contented and focused state of consciousness characterised by Christian Trinitarian imagery, wonder, surrender, peace, bliss, openness and formlessness. The neuropsychological findings indicated significant increases, from baseline to meditation recordings, in the alpha and beta range, accompanied by increasing mean trends in the theta and gamma range, and decreasing mean trends in the delta range, EMG, BVP and respiration. Integrative findings indicated the practical theological value of small doses of Christian Trinity meditation to enhance spiritual life for those forms of waking, thinking, conscious behaviour needed in everyday world involvement and healing. Findings were discussed in relation to further integrative investigations and interventions with practical theological implications. (shrink)

Reproduction, a basic property of biological life, entails costs for an organism, ultimately detectable as reduction in survival prospects. Telomeres are an excellent candidate biomarker for explaining these reproductive costs, because their shortening correlates with increased mortality risk. For similar reasons, telomeres are perceived as biomarkers of individual “quality.” The relationship between reproduction and telomere dynamics is reviewed, emphasizing that cost and quality perspectives, commonly presented in isolation, should be integrated. While a majority of correlative studies have confirmed the (...) relationship between telomere dynamics and various reproductive outputs, only limited experimental support exists showing that reproduction causes telomeres to shorten. A shift of focus to experimental manipulations of reproductive effort/telomere dynamics is crucial. However, the observation of survival reduction in response to these manipulations is essential for establishing telomeres as genuine biomarkers, allowing to unravel trade‐offs related to reproduction. (shrink)

THEOLOGICALLY CONSIDERED, THE VIRTUE OF PRUDENCE OR PRACTICAL wisdom disposes a moral agent to "reason rightly about things to be done" insofar as the acts of counsel, judgment, and command enable both the discernment and the embodiment of moral reality in the world created and redeemed by God in Jesus Christ. In that world, Christians live and act as both sinful and righteous, and they find their integrity and maturity in an ongoing practice of repentance, renewal, and perseverance.

This book examines the centrality of integrity in relation to a variety of philosophical and psychological concerns that impinge upon the ethical life.

Part biography and part constructive ethical inquiry, this book is an original interpretation of the Scottish philosopher Adam Ferguson’s ethical method and view of ethical integrity, with an emphasis on his Analysis, Institutes, and Principles.