The Roman philosopher Boethius is best known for the _Consolation of Philosophy_, one of the most frequently cited texts in medieval literature. In the _Consolation_, an unnamed Boethius sits in prison awaiting execution when his muse Philosophy appears to him. Her offer to teach him who he truly is and to lead him to his heavenly home becomes a debate about how to come to terms with evil, freedom, and providence. The conventional reading of the _Consolation_ is that it is (...) a defense of pagan philosophy; nevertheless, many readers who accept this basic argument find that the ending is ambiguous and that Philosophy has not, finally, given the prisoner the comfort she had promised. In _The Prisoner's Philosophy_, Joel C. Relihan delivers a genuinely new reading of the _Consolation_. He argues that it is a Christian work dramatizing not the truths of philosophy as a whole, but the limits of pagan philosophy in particular. He views it as one of a number of literary experiments of late antiquity, taking its place alongside Augustine's _Confessions_ and _Soliloquies_ as a spiritual meditation, as an attempt by Boethius to speak objectively about the life of the mind and its relation to God. Relihan discerns three fundamental stories intertwined in the _Consolation_: an ironic retelling of Plato's _Crito,_ an adaptation of Lucian's _Jupiter Confutatus,_ and a sober reduction of _Job_ to a quiet dialogue in which the wounded innocent ultimately learns wisdom in silence. Relihan's claim that Boethius's text was written as a Menippean satire does not rest merely on identifying a mixture of disparate literary influences on the text, or on the combination of verse and prose or of fantasy and morality. More important, Relihan argues, Boethius deliberately dramatizes the act of writing about systematic knowledge in a way that calls into question the value of that knowledge. Philosophy's attempt to lead an exile to God's heaven is rejected; the exile comes to accept the value of the phenomenal world, and theology replaces philosophy to explain the place of human beings in the order of the world. Boethius Christianizes the genre of Menippean satire, and his _Consolation_ is a work about humility and prayer. _“Acknowledging that the _Consolation of Philosophy_ is ‘over-familiar and under-read,’ Joel Relihan puts to the side old bromides about the work and instead pays careful attention to the narrative Boethius constructs, grounding his readings in the contexts the work cultivates, especially its Menippean elements. The result is perhaps the first satisfying reading of the _Consolation_ to be produced, a satisfaction felt also in the ways Relihan mirrors Boethius himself in the thoroughness of his scholarship and the elegance of his exposition. No one who studies Boethius will be able to ignore this book.“ — Joseph Pucci, Brown University _ "Anyone who has been fascinated, intrigued, or perhaps puzzled by the meaning, structure, or argument of Boethius's _Consolation of Philosophy_ will find Joel Relihan's new book a welcome addition to the study of this core text of the early medieval world whose influence extends to the present time. Relihan's study is a tour de force that belongs in the library of all those who appreciate Boethius's depth and subtlety. Fortune's wheel has indeed turned in the favor of those who wish to explore with Relihan the intricacies and brilliance of the _Consolation_." —_Fr. John Fortin, O.S.B., Saint Anselm College _. (shrink)

The formation of a highly condensed chromosome structure (heterochromatin) in a region of a eukaryotic chromosome can inactivate the genes within that region. Genetic studies using the fruitfly Drosophila melanogaster have identified several essential genes which influence the formation of heterochromatin. My purpose in this review is to summarize some recent work on the genetics of heterochromatin assembly in Drosophila and a recent model for how chromosomal proteins may interact to form a heterochromatic structure.

Eukaryotes organize certain chromosomal intervals into domains capable of si lencing most genes. Examples of silencing domains include the HML/HMR loci and subtelomeric chromatin in yeast, the Barr body X chromosome in mammals, and the pericentric heterochromatin of Drosophila. Silencing chromatin is often correlated with more regularized nucleosomal array than that found in active chromatin, and transcriptional activators appear to be missing from their target sites in silent chromatin. In Drosophila, gene silencing by heterochromatin is often variegated, indicating that a (...) gene may escape silencing in some cells. In a recent study, Ahmad and Henikoff(1) show that a yeast activator can compete successfully with Drosophila heterochromatic silencing factors for target sites in DNA. This competition, together with developmental change in the stability of heterochromatin itself, decides the transcriptional state for a gene subject to heterochromatin repression. BioEssays 23:767–771, 2001. © 2001 John Wiley & Sons, Inc. (shrink)

Most tissues contain cells capable of the self‐renewal and differentiation necessary to maintain tissue and organ integrity. These somatic stem cells are generally thought to have limited developmental potential. The mechanisms that restrict cell fate decisions in somatic stem cells are only now being understood. This understanding will be important in the clinical exploitation of adult stem cells in tissue repair and replacement. Experiments performed over fifty years ago in Drosophila showed that developmental restriction could be relaxed in the proliferating (...) larval cells that are destined to form the adult fly integument. This phenomenon, called transdetermination, can serve as a model for mechanisms of stem‐cell commitment. A recent publication1 sheds new light on the mechanism of transdetermination by demonstrating that loss of homeotic gene silencing leads to increased frequency of transdetermination. In addition, the authors link a specific signaling pathway induced by tissue regeneration to the relaxation of homeotic gene silencing. The data identify key mechanisms that control developmental homeostasis and cell fate restriction that could be manipulated to make somatic stem‐cell engineering possible. BioEssays 28: 574–577, 2006. © 2006 Wiley Periodicals, Inc. (shrink)

So the modern editions print the opening words of the work more popularly known as the Caesares. The Symposium begins with what I consider to be a playful encounter between the narrator and his interlocutor, in which the latter's expectations of seriousness in the myth which is to follow are frustrated. This playfulness has not been appreciated by Julian's commentators. I suggest that we have here a concealed trimeter which figures largely in the dynamics of this dialogue : γελοον οδν (...) σδ τερπνν οδ' γ. (shrink)

So the modern editions print the opening words of the work more popularly known as the Caesares. The Symposium begins with what I consider to be a playful encounter between the narrator and his interlocutor, in which the latter's expectations of seriousness in the myth which is to follow are frustrated. This playfulness has not been appreciated by Julian's commentators. I suggest that we have here a concealed trimeter which figures largely in the dynamics of this dialogue :γελο⋯ον οὐδ⋯ν σὐδ⋯ (...) τερπν⋯ν οἶδ' ⋯γώ. (shrink)

Compassion is a prosocial motivation that is critical to the development and survival of the human species. Cultivating compassion involves developing deep wisdom, insight, and understanding into the nature and causes of human suffering; and wisdom and commitment to take positive action to alleviate suffering. This perspective piece discusses how compassion relates to the context of modern technology, which has developed at a rapid pace in recent decades. While advances in digital technology build on humankind’s vast capacity to develop practical (...) tools that promise to enrich our lives and improve our social connections, in reality the effects are often far from benign. The motives underlying the development of many contemporary digital platforms seem rooted in competitiveness and capitalism; while modern social media and online platforms are having a profound and pervasive impact on the mental health and wellbeing of humans around the globe. Nonetheless, digital technology holds considerable potential to promote compassionate insight, wisdom, and prosocial behavior. We reflect on the current state of technology within human society and examine the notion of compassionate technologies; discuss how contemporary paradigm shifts such as the inclusive design movement may be harnessed to build tools and platforms that promote collective good and increase prosocial behavior; and highlight examples of initiatives that are harnessing modern technology to advance democracy, collective knowledge, and personal freedoms and agency. (shrink)

Although Broad published many books in his lifetime, this volume is unique in presenting some of his most interesting unpublished writings. Divided into five clear sections, the following figures and topics are covered: Autobiography, Hegel and the nature of philosophy, Francis Bacon, Hume's philosophy of the self and belief, F. H. Bradley, The historical development of scientific thought from Pythagoras to Newton, Causation, Change and continuity, Quantitative methods, Poltergeists, Paranormal phenomena. -/- Each section is introduced and placed in context by (...) the editor, Joel Walmsley. The volume also includes an engaging and informative foreword by Simon Blackburn. It will be of great value to those studying and researching the history of twentieth-century philosophy, metaphysics, and the recent history and philosophy of science, as well as anyone interested in Broad's philosophical thought and his place in the history of philosophy. (shrink)

Volume 20, Issue 4, May 2020, Page 76-78.

Civility is an essential feature of health care, as it is in so many other areas of human interaction. The article examines the meaning of civility, reviews its origins, and provides reasons for its moral significance in health care. It describes common types of uncivil behavior by health care professionals, patients, and visitors in hospitals and other health care settings, and it suggests strategies to prevent and respond to uncivil behavior, including institutional codes of conduct and disciplinary procedures. The article (...) concludes that uncivil behavior toward health care professionals, patients, and others subverts the moral goals of health care and is therefore unacceptable. Civility is a basic professional duty that health care professionals should embrace, model, and teach. (shrink)

Biological evolution provides a creative fount of complex and subtle adaptations, often surprising the scientists who discover them. However, because evolution is an algorithmic process that transcends the substrate in which it occurs, evolution’s creativity is not limited to nature. Indeed, many researchers in the field of digital evolution have observed their evolving algorithms and organisms subverting their intentions, exposing unrecognized bugs in their code, producing unexpected adaptations, or exhibiting outcomes uncannily convergent with ones in nature. Such stories routinely reveal (...) creativity by evolution in these digital worlds, but they rarely fit into the standard scientific narrative. Instead they are often treated as mere obstacles to be overcome, rather than results that warrant study in their own right. The stories themselves are traded among researchers through oral tradition, but that mode of information transmission is inefficient and prone to error and outright loss. Moreover, the fact that these stories tend to be shared only among practitioners means that many natural scientists do not realize how interesting and lifelike digital organisms are and how natural their evolution can be. To our knowledge, no collection of such anecdotes has been published before. This paper is the crowd-sourced product of researchers in the fields of artificial life and evolutionary computation who have provided first-hand accounts of such cases. It thus serves as a written, fact-checked collection of scientifically important and even entertaining stories. In doing so we also present here substantial evidence that the existence and importance of evolutionary surprises extends beyond the natural world, and may indeed be a universal property of all complex evolving systems. (shrink)

This is the first book to offer the best essays, articles, and speeches on ethics and intelligence that demonstrate the complex moral dilemmas in intelligence collection, analysis, and operations. Some are recently declassified and never before published, and all are written by authors whose backgrounds are as varied as their insights, including Robert M. Gates, former Director of the Central Intelligence Agency; John P. Langan, the Joseph Cardinal Bernardin Professor of Catholic Social Thought at the Kennedy Institute of Ethics, Georgetown (...) University; and Loch K. Johnson, Regents Professor of Political Science at the University of Georgia and recipient of the Owens Award for contributions to the understanding of U.S. intelligence activities. Creating the foundation for the study of ethics and intelligence by filling in the gap between warfare and philosophy, this is a valuable collection of literature for building an ethical code that is not dependent on any specific agency, department, or country. (shrink)

Volume 20, Issue 6, June 2020, Page 17-19.

Because no single person or group holds knowledge about all aspects of research, mechanisms are needed to support knowledge exchange and engagement. Expertise in the research setting necessarily includes scientific and methodological expertise, but also expertise gained through the experience of participating in research and/or being a recipient of research outcomes. Engagement is, by its nature, reciprocal and relational: the process of engaging research participants, patients, citizens and others brings them closer to the research but also brings the research closer (...) to them. When translating research into practice, engaging the public and other stakeholders is explicitly intended to make the outcomes of translation relevant to its constituency of users. In practice, engagement faces numerous challenges and is often time-consuming, expensive and ‘thorny’ work. We explore the epistemic and ontological considerations and implications of four common critiques of engagement methodologies that contest: representativeness, communication and articulation, impacts and outcome, and democracy. The ECOUTER methodology addresses problems of representation and epistemic foundationalism using a methodology that asks, “How could it be otherwise?” ECOUTER affords the possibility of engagement where spatial and temporal constraints are present, relying on saturation as a method of ‘keeping open’ the possible considerations that might emerge and including reflexive use of qualitative analytic methods. This paper describes the ECOUTER process, focusing on one worked example and detailing lessons learned from four other pilots. ECOUTER uses mind-mapping techniques to ‘open up’ engagement, iteratively and organically. ECOUTER aims to balance the breadth, accessibility and user-determination of the scope of engagement. An ECOUTER exercise comprises four stages: engagement and knowledge exchange; analysis of mindmap contributions; development of a conceptual schema ; and feedback, refinement and development of recommendations. ECOUTER refuses fixed truths but also refuses a fixed nature. Its promise lies in its flexibility, adaptability and openness. ECOUTER will be formed and re-formed by the needs and creativity of those who use it. (shrink)

This book broadens the inquiry into emotion to comprehend a comparative cultural outlook. It begins with an overview of recent work in the West, and then proceeds to the main business of scrutinizing various relevant issues from both Asian and comparative perspectives. Original essays by experts in the field. Finally, Robert Solomon comments and summarizes.

The relationship between democracy and constitutions is a long and fractious one. Those who lean towards the constitutionalist side have tended to perceive democracy as a threat to political order and the preservation of important values, whereas those who take a more democratist stance tend to treat constitutions as elite hindrances to popular rule as much as anything else. In this paper, we will give the constitutionalist thesis a broader theoretical and political scrutiny. By way of explanation, we will address (...) and recommend the possibilities and problems for putting into practical operation such an anti-constitutionalist stance; the recent experience of the U.S. State of California offers itself as a good forcing-ground for these ideas. In short, from a democratic standpoint, the challenge for the citizenry is not so much about defining the values of constitutions, but constitutions whose change is outside the scope of popular decision making, supposed to exclusively take place through judicial interpretation or through an amendment formula designed precisely to make change difficult and unlikely. Too often, constitutions place checks and limits on democratic participation in the name of some other set of vaunted truths or elite-favouring values. For the strong democrat, it is formal constitutions and their institutional paraphernalia that do more to inhibit and dull democracy's emancipatory potential than to nurture and fulfil it. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:THEOLOGY, PRAXIS, AND ETHICS IN THE THOUGHT OF JUAN LUIS SEGUNDO, S.J. JOEL ZIMBELMAN California State University, Chico Chico, California I. Introduction JESUS OF NAZARETH Yesterday and Today is Juan Luis Segundo's most recent contribution in an on-going effort to forge a distinctive post-conciliar catholic theology.1· This five-volume work establishes Segundo as one of the most prolific, methodologically sophisticated, and constructive Catholic theologians of this century. In these (...) volumes he moves beyond the task of reframing fundamental theology in political and social terms that he began in earlier works and undertakes a full elaboration of the theological method that he introduced in The Liberation of Theology.2 Better than any previous work, the recent effort witnesses to the author's range of interests and strengths, 1 Originally published in the Spanish as El hombre de hoy ante Jesus de Nazaret (Madrid: Ediciones Christiandad, 1982): Vol. I. Fe e ideologia; Vol. II/1 and 2 Historia y actualidad: Sinopticos y Pablo; Vol. II/3 El Cristo de los ejercicios espirituales; Vol. II/4 Lineas actuates de interpretacion de Jesus de Nazaret. English translation Jesus of Nazareth Yesterday and Today, tr. John Drury (Maryknoll, N.Y.: Orbis Books) : vol. 1 Faith and Ideologies (1984); vol. 2 The Historical Jesus of the Synoptics (1985); vol. 3 The Humanist Christology of Paul (1986) ; vol. 4 The Christ of the Ignatian Exercises (1987); vol. 5 An Evolutionary Approach to Jesus of Nazareth (1988). 2 The Liberation of Theology, tr. John Drury (Maryknoll, N.Y.: Orbis Books, 1976). For earlier efforts at political and social theology, see A Theology for Artisans of A New Humanity, tr. John Drury (Maryknoll, N.Y.: Orbis Books): vol. 1 The Community Called Church (1973); vol. 2 Grace and the Human Condition (1973) ; vol. 3 Our Idea of God (1973) ; vol. 4 The Sacraments Today (1974); vol. 5 Evolution and Guilt (1974). 233 234 JOEL ZIMBELMAN including theology and philosophy, hermeneutics and critical social theory, linguistic theory, and biblical studies. Continuing analysis and assessment of liberation theory, and Segundo's recent effort in particular, is warranted for at least three reasons. First, Jesus of Nazareth and particularly its first volume, Faith and Ideologies, clarifies Segundo's constructive project. The volume reasserts much that is already familiar to Segundo's past readers : a deconstructive hermeneutic; the elaboration of the concepts of faith and ideology; and an interpretation of the relationship of faith to praxis, efficacy, and liberation. But it also breaks new and creative ground as it begins to construct the foundations of a moral epistemology and teleology, a more fully developed theory of value appropriation, and an anthropology grounded in transcendental-existentialist and process categories. One can only appreciate the scope and implications of Segundo's thought in a critical analysis of this recent work. Second, Segundo's ·effort calls for further discussion because of its inevitable influence on the development of other constructive and critical Christian theologies. The visions of " geotheology,'' "world Catholicism," and a "liberating theology" advanced by Latin and North American Catholics are no longer the preoccupations of a peripheral minority but reflect the aspirations of conservative, moderate, and progressive voices in the Christian church. As part of this constructive task, a growing number of contemporary thinkers are addressing concerns or appropriating categories and constructs developed or elaborated by Segundo.8 His theological breadth and sophistication means 8 For discussions of this shift, see Alfred Hennelly, "Today's New Task: Geotheology,'' America 18 (January 1975): 27-29; and Penny Lernoux, People of God: The Struggle for World Catholicism (New York: Viking/ Penguin, 1989). Those either indebted to or engaged in substantial conversation with Segundo include Matthew Lamb, Solidarity With Victims: Toward a Theology of Social Transformation (New York: Crossroads, 1982) ; Congregation for the Doctrine of the Faith, " Instruction on Christian Freedom and Liberation," Origins: N. C. Documentary Service 15 (17 April 1986): 713-27; Rebecca Chopp, The Praxis of Suffering: An Interpretation of Liberation and Political Theologies (Maryknoll, N.Y.: Orbis Books, 1986) ; Alfred Hennelly, Theology for a Liberating Church: The New Praxis of Freedom (Washington, D.C.: Georgetown University Press, 1989). TltOUGB:T OF JUAN LUlS SEGUNbO, S.J. 235 that... (shrink)

In face of the multiple controversies surrounding the DSM process in general and the development of DSM-5 in particular, we have organized a discussion around what we consider six essential questions in further work on the DSM. The six questions involve: 1) the nature of a mental disorder; 2) the definition of mental disorder; 3) the issue of whether, in the current state of psychiatric science, DSM-5 should assume a cautious, conservative posture or an assertive, transformative posture; 4) the role (...) of pragmatic considerations in the construction of DSM-5; 5) the issue of utility of the DSM – whether DSM-III and IV have been designed more for clinicians or researchers, and how this conflict should be dealt with in the new manual; and 6) the possibility and advisability, given all the problems with DSM-III and IV, of designing a different diagnostic system. Part 1 of this article took up the first two questions. Part 2 took up the second two questions. Part 3 now deals with Questions 5 & 6. Question 5 confronts the issue of utility, whether the manual design of DSM-III and IV favors clinicians or researchers, and what that means for DSM-5. Our final question, Question 6, takes up a concluding issue, whether the acknowledged problems with the earlier DSMs warrants a significant overhaul of DSM-5 and future manuals. As in Parts 1 & 2 of this article, the general introduction, as well as the introductions and conclusions for the specific questions, are written by James Phillips, and the responses to commentaries are written by Allen Frances. (shrink)

Is the societal-level of analysis sufficient today to understand the values of those in the global workforce? Or are individual-level analyses more appropriate for assessing the influence of values on ethical behaviors across country workforces? Using multi-level analyses for a 48-society sample, we test the utility of both the societal-level and individual-level dimensions of collectivism and individualism values for predicting ethical behaviors of business professionals. Our values-based behavioral analysis indicates that values at the individual-level make a more significant contribution to (...) explaining variance in ethical behaviors than do values at the societal-level. Implicitly, our findings question the soundness of using societal-level values measures. Implications for international business research are discussed. (shrink)

Collection of original essays on the theory of desire by Robert Audi, Annette Baier, Wayne Davis, Ronald de Sousa, Robert Gordon, O.H. Green, Joel Marks, Dennis Stampe, Mitchell Staude, Michael Stocker, and C.C.W. Taylor.