Selected aneuploidies can be rapidly diagnosed by the analysis of fluorescent polymerase chain reaction (PCR) products of chromosome‐specific and highly polymorphic small tandem repeats (STRs). The quantitative STR patterns obtained from samples of normal individuals are markedly different from those seen when patients with aneuploidies involving chromosome X, or trisomies of chromosomes 21 and 18, are tested. For example, while samples from normal subjects – tested with a chromosome 21‐derived STR (D21S11) – show two fluorescent PCR peaks with similar activities (...) in a 1:1 ratio, the analysis of samples from patients with trisomy 21 reveals the presence of either three peaks (ratio 1:1:1), or two peaks with a ratio of 2:1. The use of an internal non‐polymorphic marker allows identification of trisomic samples with three copies of the same allele. This rapid approach (24 hours) is particularly valuable when applied to prenatal diagnosis of chromosomal abnormalities since it reduces the time of anxiety of the parents waiting for the results of the conventional cytogenetic tests, which require several weeks. (shrink)

Anthropology of Consciousness, Volume 33, Issue 1, Page 38-62, Spring 2022.

Despite society’s increasing sensitivity toward green production, companies often struggle to find effective communication strategies that induce consumers to buy green products or engage in other environmentally friendly behaviors. To add clarity to this situation, we investigated the effectiveness of negative versus positive message framing in promoting green products, whereby companies highlight the detrimental versus beneficial environmental consequences of choosing less versus more green options, respectively. Across four experiments, we show that negatively framed messages are more effective than positively framed (...) ones in prompting consumers to engage in pro-environmental behaviors. More importantly, we find that anticipated shame is the emotion responsible for this effect. Furthermore, both environmental concern and the type of product promoted serve as moderators; thus, the mediating role of anticipated shame is attenuated when environmental concern is low and the product is a luxury one. Finally, we discuss the theoretical and managerial implications of our work, along with its limitations and some directions for future research. (shrink)

We study ultimatum and dictator variants of the generosity game. In this game, the first mover chooses the amount of money to be distributed between the players within a given interval, knowing that her own share is fixed. Thus, the first mover is not confronted with the typical trade-off between her own and the other’s payoff. For each variant of the game, we study three treatments that vary the range of potential pie sizes so as to assess the influence of (...) these changes on the first movers’ generosity. We find that removing the trade-off inspires significant generosity, which is not always affected by the second mover’s veto power. Moreover, the manipulation of the choice set indicates that choices are influenced by the available alternatives. (shrink)

In the Peruvian Amazon, tobacco (Nicotiana rustica) is considered a master plant and is the main curing tool of local healers. Among its several medicinal uses, we find drinking tobacco juice with the purpose of purging in order to heal on a physical, mental, and spiritual level. This specific practice is part of the addiction treatment protocol developed at Takiwasi Center. The goal of this investigation was to focus on the effects of the tobacco purge as reported by therapists at (...) Takiwasi and to elaborate its relevance within the context of addiction treatment. In order to obtain information on this topic, we performed research fieldwork based on a participant-observation approach, and retrospective data analysis on information from interviews conducted by psychotherapists with patients. As alleged effects of the tobacco purge, therapists reported that patients experienced feelings of mental clarity with the greatest frequency (n = 80), followed by noteworthy physical effects including discomfort and intoxication (n = 63). An effect on sleep and dreams was also common (n = 36) and many found the experience directly related to addiction treatment and the desire to consume substances (n = 20). (shrink)

Teaching business ethics effectively may prepare future leaders and managers to better deal with delicate situations that they might face in the workplace. However, such an aim is one of the biggest challenges that educators at universities are called on to solve. An increasing number of scholars are invoking the role of prudence in the virtue ethics context as a viable approach to teach students how to manage ethical dilemmas. In this regard, this paper discusses the “St. Albans Family Enterprises” (...) case study that can serve as an instrument to help students and practitioners develop their ethical decision-making ability and to foster a disposition towards applying sound judgment or what can be called in classical terms, prudence. The teaching note that accompanies the case study offers guidance to educators about how the case can be used for teaching purposes, and explains the implications of exercising practical wisdom within a virtue ethics framework. (shrink)

Natural selection is commonly seen not just as an explanation for adaptive evolution, but as the inevitable consequence of “heritable variation in fitness among individuals”. Although it remains embedded in biological concepts, such a formalisation makes it tempting to explore whether this precondition may be met not only in life as we know it, but also in other physical systems. This would imply that these systems are subject to natural selection and may perhaps be investigated in a biological framework, where (...) properties are typically examined in light of their putative functions. Here we relate the major questions that were debated during a three-day workshop devoted to discussing whether natural selection may take place in non-living physical systems. We start this report with a brief overview of research fields dealing with “life-like” or “proto-biotic” systems, where mimicking evolution by natural selection in test tubes stands as a major objective. We contend the challenge may be as much conceptual as technical. Taking the problem from a physical angle, we then discuss the framework of dissipative structures. Although life is viewed in this context as a particular case within a larger ensemble of physical phenomena, this approach does not provide general principles from which natural selection can be derived. Turning back to evolutionary biology, we ask to what extent the most general formulations of the necessary conditions or signatures of natural selection may be applicable beyond biology. In our view, such a cross-disciplinary jump is impeded by reliance on individuality as a central yet implicit and loosely defined concept. Overall, these discussions thus lead us to conjecture that understanding, in physico-chemical terms, how individuality emerges and how it can be recognised, will be essential in the search for instances of evolution by natural selection outside of living systems. (shrink)

This paper investigates the question of how we manage to single out the natural number structure as the intended interpretation of our arithmetical language. Horsten submits that the reference of our arithmetical vocabulary is determined by our knowledge of some principles of arithmetic on the one hand, and by our computational abilities on the other. We argue against such a view and we submit an alternative answer. We single out the structure of natural numbers through our intuition of the absolute (...) notion of finiteness. (shrink)

With the purpose of introducing a useful tool for researches concerning foundations of quantum mechanics and applications to quantum technologies, here we address three quantumness quantifiers for bipartite optical systems: one is based on sub-shot-noise correlations, one is related to antibunching and one springs from entanglement determination. The specific cases of parametric downconversion seeded by thermal, coherent and squeezed states are discussed in detail.

According to the received view of evolution, only genes are inherited. From this view it follows that only genetically-caused phenotypic variation is selectable and, thereby, that all selection is at bottom genetic selection. This paper argues that the received view is wrong. In many species, there are intergenerationally-stable phenotypic differences due to environmental differences. Natural selection can act on these nongenetically-caused phenotypic differences in the same way it acts on genetically-caused phenotypic differences. Some selection is at bottom nongenetic selection. The (...) argument against the received view involves a reformulation of the concepts of inheritance and heritability. Inherited factors are all those developmental factors responsible for parent–offspring similarity; some inherited factors are genetic and some are not. Heritable variation is intergenerationally-stable phenotypic variation; some such variation is genetically-caused and some is not. The received view and its critics The possibility of nongenetic selection (the lucky butterfly) The reality of nongenetic selection 3.1 Imprinting mechanisms 3.2 Other learning mechanisms 3.3 Other nongenetic mechanisms Genetic and nongenetic inheritance mechanisms Genetic and nongenetic inherited factors Genetic and nongenetic heritability Conclusions + Current address: Dr Matteo Mameli, Research Fellow, King's College, Cambridge, CB2 1ST, United Kingdom, matteo.mameli{at}kings.cam.ac.uk' + u + '@' + d + ''//-->. (shrink)

O argumento do filme Rashômon de Akira Kurosawa suscita de um modo provocatório o problema a que o presente artigo pretende dar uma resposta. Como é possível discernir, em relação a um facto histórico, o verdadeiro do falso? Existe um saber capaz de nos ajudar a regular e a orientar o nosso juízo nas experiências humanas? Mostra-se, com efeito, que tanto para Pascal como para Kierkegaard existe um saber específico que tem por objecto o mundo histórico; este saber é a (...) fé, a crença. Mas se para Pascal os conhecimentos de carácter histórico, desde que submetidos a verificação adequada, podem alcançar o mesmo grau de certeza do saber científico, e se Pascal, com base nesta convicção, utilizou as provas históricas para demonstrar a verdade do cristianismo, para Kierkegaard, por sua vez, nenhuma verificação pode tornar certo aquilo que é constitutivamente incerto. Com Lessing, de facto, Kierkegaard defende que "verdades históricas fortuitas" não podem jamais tornar-se uma prova para as "verdades eternas da razão". /// The argument of Akira Kurosawa's movie Rashômon raises the question to which the present article aims at giving an answer. How is it possible to discern, regarding an historical fact, the true from the false? Is there a knowledge that can help us to regulate and to orient our judgment within the realm of human experience? For Pascal and for Kierkegaard there exists a specific wisdom that has as object the historical world, and this knowledge is faith, belief. But if for Pascal historical knowledge, once it is subjected to adequate verification, can reach the same degree of certainty as scientific knowledge, and if Pascal, on the basis of this conviction, has used the historical proofs in order to demonstrate the truth of Christianity, for Kierkegaard, on the other hand, there is no verification possible that can make certain that that is constitutionally uncertain. With Lessing, in fact, Kierkegaard defends that "fortuitous historical truths" can never become proof for the "eternal truth of reason". (shrink)

Recent studies suggest that a non‐isotopic in situ hybridisation (NISH) approach can be successfully employed to investigate the carrier status of female relatives in families of selected patients with Duchenne muscular dystrophy (DMD) or Hunter syndrome, whose diseases are due to a specific X chromosome deletion.Whilst the majority of metaphase spreads from normal females show specific hybridisation signals on both X chromosomes when tested with either dystrophin or Hunter gene‐derived probes, only one X chromosome in each metaphase spread will show (...) the relevant hybridisation complex in female carriers of deletions involving the dystrophin or Hunter gene.Thus, the NISH method can be a valuable diagnostic tool for the detection of the carrier status of female relatives of patients with X chromosome deletions. (shrink)

The paper investigates the ethics of information transparency (henceforth transparency). It argues that transparency is not an ethical principle in itself but a pro-ethical condition for enabling or impairing other ethical practices or principles. A new definition of transparency is offered in order to take into account the dynamics of information production and the differences between data and information. It is then argued that the proposed definition provides a better understanding of what sort of information should be disclosed and what (...) sort of information should be used in order to implement and make effective the ethical practices and principles to which an organisation is committed. The concepts of “heterogeneous organisation” and “autonomous computational artefact” are further defined in order to clarify the ethical implications of the technology used in implementing information transparency. It is argued that explicit ethical designs, which describe how ethical principles are embedded into the practice of software design, would represent valuable information that could be disclosed by organisations in order to support their ethical standing. (shrink)

The present paper discusses different approaches to metaphysics and defends a specific, non-deflationary approach that nevertheless qualifies as scientifically-grounded and, consequently, as acceptable from the naturalistic viewpoint. By critically assessing some recent work on science and metaphysics, we argue that such a sophisticated form of naturalism, which preserves the autonomy of metaphysics as an a priori enterprise yet pays due attention to the indications coming from our best science, is not only workable but recommended.

The concept of innateness is a part of folk wisdom but is also used by biologists and cognitive scientists. This concept has a legitimate role to play in science only if the colloquial usage relates to a coherent body of evidence. We examine many different candidates for the post of scientific successor of the folk concept of innateness. We argue that none of these candidates is entirely satisfactory. Some of the candidates are more interesting and useful than others, but the (...) interesting candidates are not equivalent to each other and the empirical and evidential relations between them are far from clear. Researchers have treated the various scientific notions that capture some aspect of the folk concept of innateness as equivalent to each other or at least as tracking properties that are strongly correlated with each other. But whether these correlations exist is an empirical issue. This empirical issue has not been thoroughly investigated because in the attempt to create a bridge between the folk view and their theories, researchers have often assumed that the properties must somehow cluster. Rather than making further attempts to import the folk concept of innateness into the sciences, efforts should now be made to focus on the empirical questions raised by the debates and pave the way to a better way of studying the development of living organisms. Such empirical questions must be answered before it can be decided whether a good scientific successor – in the form of a concept that refers to a collection of biologically significant properties that tend to co-occur – can be identified or whether the concept of innateness deserves no place in science. (shrink)

The metaphysics of powers (Shoemaker, 1980; Mumford, 2004; Marmodoro, 2009; Heil, 2012 among many others) is a promising conceptual framework that has been successfully put to use in many philosophical and scientific domains, but surprisingly its potential applications in the contemporary philosophy of mind are still under-investigated. This thematic issue aims to show that power ontology has implications concerning major questions in the contemporary philosophy of mind, such as: what is the metaphysical relationship between consciousness and the physical? Are phenomenal (...) properties reducible to physical properties, fundamental, or emergent? How are we to explain notions such as belief, agency, and free will? (shrink)

As innovations in the field of vascular composite allotransplantation (VCA) progress, whole-eye transplantation (WET) is poised to transition from non-human mammalian models to living human recipients. Present treatment options for vision loss are generally considered suboptimal, and attendant concerns ranging from aesthetics and prosthesis maintenance to social stigma may be mitigated by WET. Potential benefits to WET recipients may also include partial vision restoration, psychosocial benefits related to identity and social integration, improvements in physical comfort and function, and reduced surgical (...) risk associated with a biologic eye compared to a prosthesis. Perioperative and postoperative risks of WET are expected to be comparable to those of facial transplantation (FT), and may be similarly mitigated by immunosuppressive protocols, adequate psychosocial support, and a thorough selection process for both the recipient and donor. To minimize the risks associated with immunosuppressive medications, the first attempts in human recipients will likely be performed in conjunction with a FT. If first-in-human attempts at combined FT-WET prove successful and the biologic eye survives, this opens the door for further advancement in the field of vision restoration by means of a viable surgical option. This analysis integrates recent innovations in WET research with the existing discourse on the ethics of surgical innovation and offers preliminary guidance to VCA programs considering undertaking WET in human recipients. (shrink)

I present and apply some powerful tools for studying human evolution and the impact of cultural resources on it. The tools in question are a theory of niche construction and a theory about the evolutionary significance of extragenetic (and, in particular, of psychological and social) inheritance. These tools are used to show how culturally transmitted resources can be recruited by development and become generatively entrenched. The case study is constituted by those culturally transmitted items that social psychologists call ‘expectancies’. Expectancy (...) effects are mindshaping effects of our mindreading dispositions. I show how expectancies may have been recruited by important human developmental processes (like those involved in language acquisition and those responsible for gender differences) and how they may have become entrenched. If the hypothesis is correct, the relation between mindreading and human evolution is more intricate than usually thought. (shrink)

We develop a conceptual framework that connects biological heredity and organization. We refer to heredity as the cross-generation conservation of functional elements, defined as constraints subject to organizational closure. While hereditary objects are functional constituents of biological systems, any other entity that is stable across generations—and possibly involved in the recurrence of phenotypes—belongs to their environment. The central outcome of the organizational perspective consists in extending the scope of heredity beyond the genetic domain without merging it with the broad category (...) of cross-generation stability. After discussing some implications, we conclude with a reflection on the relationship between stability and variation. 1Introduction2From Extended Heredity to Cross-generation Stability 2.1Extending the scope of heredity: A brief state of the art2.2Rethinking heredity: Conceptual challenges3Biological Heredity in Light of Organization 3.1Biological organization within organisms and beyond3.2Extending organization in time3.3What is biological heredity?4Implications and Objections 4.1Heredity as a specific kind of cross-generation stability4.2Heredity at various levels of description4.3Non-functional and dysfunctional objects5Conclusions: From Conservation to Variation. (shrink)

Accelerating environmental uncertainty and the need to cope with increasingly complex market and social demands, combine to create high value for the intuitive approach to decision-making at the strategic level. Research on intuition suffers from marked fragmentation, due to the existence of disciplinary silos based on diverse, apparently irreconcilable, ontological and epistemological assumptions. Not surprisingly, there is no integrated interdisciplinary framework suitable for a rich account of intuition, contemplating how affect and cognition intertwine in the intuitive process, and how intuition (...) scales up from the individual to collective decision-making. This study contributes to the construction of a broad conceptual framework, suitable for a multi-level account of intuition and for a fruitful dialogue with distant research areas. It critically discusses two mainstream conceptualizations of intuition which claim to be grounded in a cross-disciplinary consensus. Drawing on the complexity paradigm, it then proposes a conceptualization of intuition as emergence. Finally, it explores the theoretical and practical implications. (shrink)

This paper introduces a new framework, based on the notion of compatibility space, obtained by adding a primitive incompatibility relation to a state space in the sense of Fine. The key idea inspiring the framework is to modify Fine's truthmaker semantics by taking the notion of incompatibility as primitive, and use it to define other notions. We discuss some interesting features of the framework and explore its advantages over the standard framework of state spaces. We review some applications of the (...) framework, including proofs of soundness and completeness theorems for a number of logics, one way to use compatibility states to mirror Kripke frames, and an exploration of a way to use the new framework to provide truthmaking clauses for modal formulas. (shrink)

An argument to the effect that, under a few reasonable assumptions, the bare particular ontology is best understood in terms of supersubstativalism: objects are identical to regions of space(-time) and properties directly inhere in space(-time) points or region as their bearers.

This paper contributes to the debate on online trust addressing the problem of whether an online environment satisfies the necessary conditions for the emergence of trust. The paper defends the thesis that online environments can foster trust, and it does so in three steps. Firstly, the arguments proposed by the detractors of online trust are presented and analysed. Secondly, it is argued that trust can emerge in uncertain and risky environments and that it is possible to trust online identities when (...) they are diachronic and sufficient data are available to assess their reputation. Finally, a definition of trust as a second-order property of first-order relation is endorsed in order to present a new definition of online trust. According to such a definition, online trust is an occurrence of trust that specifically qualifies the relation of communication ongoing among individuals in digital environments. On the basis of this analysis, the paper concludes by arguing that online trust promotes the emergence of social behaviours rewarding honest and transparent communications. (shrink)

This article offers a limited defense of metaphysical “infinitism,” the view that there are, or might be, infinite chains of ontological dependence. According to a widespread presupposition, there must be an ultimate ground of being—most likely, a plurality of fundamental atoms. Contrary to this view, this article shows that metaphysical infinitism is internally coherent. In particular, a parallel with the debate concerning infinitism about epistemic justification is suggested, and an “emergence model” of being is put forward. According to the emergence (...) model, the being of any given entity gradually arises out of an infinite series of progressively less dependent entities—it is not wholly transmitted, as it were, from a basic, ungrounded level to all the dependent ones in a step-by-step fashion. Some objections are considered and rebutted. (shrink)

Courtesy of its free energy formulation, the hierarchical predictive processing theory of the brain (PTB) is often claimed to be a grand unifying theory. To test this claim, we examine a central case: activity of mesocorticolimbic dopaminergic (DA) systems. After reviewing the three most prominent hypotheses of DA activity—the anhedonia, incentive salience, and reward prediction error hypotheses—we conclude that the evidence currently vindicates explanatory pluralism. This vindication implies that the grand unifying claims of advocates of PTB are unwarranted. More generally, (...) we suggest that the form of scientific progress in the cognitive sciences is unlikely to be a single overarching grand unifying theory. (shrink)

Some naturalistic philosophers of mind subscribing to the predictive processing theory of mind have adopted a realist attitude towards the results of Bayesian cognitive science. In this paper, we argue that this realist attitude is unwarranted. The Bayesian research program in cognitive science does not possess special epistemic virtues over alternative approaches for explaining mental phenomena involving uncertainty. In particular, the Bayesian approach is not simpler, more unifying, or more rational than alternatives. It is also contentious that the Bayesian approach (...) is overall better supported by the empirical evidence. So, to develop philosophical theories of mind on the basis of a realist interpretation of results from Bayesian cognitive science is unwarranted. Naturalistic philosophers of mind should instead adopt an anti-realist attitude towards these results and remain agnostic as to whether Bayesian models are true. For continuing on with an exclusive focus and praise of Bayes within debates about the predictive processing theory will impede progress in philosophical understanding of scientific practice in computational cognitive science as well as of the architecture of the mind. (shrink)

Who is responsible when an AI machine causes something to go wrong? Or is there a gap in the ascription of responsibility? Answers range from claiming there is a unique responsibility gap, several different responsibility gaps, or no gap at all. In a nutshell, the problem is as follows: on the one hand, it seems fitting to hold someone responsible for a wrong caused by an AI machine; on the other hand, there seems to be no fitting bearer of responsibility (...) for this wrong. In this article, we focus on a particular (aspect of the) AI responsibility gap: it seems fitting that someone should bear the legal consequences in scenarios involving AI machines with design defects; however, there seems to be no such fitting bearer. We approach this problem from the legal perspective, and suggest vicarious liability of AI manufacturers as a solution to this problem. Our proposal comes in two variants: the first one has a narrower range of application, but can be easily integrated in current legal frameworks; the second one requires a revision of current legal frameworks, but has a wider range of application. The latter variant employs a broadened account of vicarious liability. We emphasise strengths of the two variants and finally highlight how vicarious liability offers important insights for addressing a moral AI responsibility gap. (shrink)

This open access book assesses the prospects of (re)adopting organization as a pivotal concept in biology. It shows how organization can nourish biological thinking and practice, by reconnecting with the idea of biology as the science of organized systems. The book provides a comprehensive state-of-the-art picture of the characterizations and uses of the concept of organization in both biological science and philosophy of biology. It also deals with a variety of themes – including evolution, organogenesis, heredity, cognition and ecology – (...) with respect to which the concept of organization can guide the elaboration of original models and new experimental protocols. It will be of interest to biologists and scholars working in philosophy of science alike. (shrink)

The present paper argues that the typical structuralist claims according to which invariances, symmetries and the like are fundamental – especially in physics – should not be understood in terms of physical relations being fundamental. Rather, they should be understood in terms of ‘metaphysical coherentism’ - the idea that object-like parts of reality exhibit symmetric relations of ontological dependence. The view is developed in some detail, in particular by showing that i) symmetric ontological dependence does not necessarily lead to uninformative (...) metaphysical explanations, and ii) metaphysical coherentism strikes the best balance between the requirements of naturalism and those of theoretical consistency – especially in view of the difficulties that structuralists seem to have in accounting for all state-independent properties of particles in relational terms. On this basis, the coherentist picture is applied to the interpretation of the quantum domain, and contrasted with extant varieties of structuralism, of both the eliminative and the non-eliminative sort, and holism. (shrink)

This is the second part of an overview article on fundamentality in metaphysics and the philosophy of physics. Here, the notion of fundamentality is looked at from the viewpoint of the philosophical analysis of physics and physical theories. The questions are considered (1) whether physics can be regarded as fundamental with respect to other sciences, and in what sense; (2) what the label ‘fundamental physics’ should exactly be taken to mean; (3) on what grounds a particular physical theory should be (...) considered fundamental; (4) what should be regarded as fundamental according to particular theories of physics; and (5) what indications come from contemporary physics concerning the fundamental structure of reality. (shrink)

The free-energy principle states that all systems that minimize their free energy resist a tendency to physical disintegration. Originally proposed to account for perception, learning, and action, the free-energy principle has been applied to the evolution, development, morphology, anatomy and function of the brain, and has been called a postulate, an unfalsifiable principle, a natural law, and an imperative. While it might afford a theoretical foundation for understanding the relationship between environment, life, and mind, its epistemic status is unclear. Also (...) unclear is how the free-energy principle relates to prominent theoretical approaches to life science phenomena, such as organicism and mechanism. This paper clarifies both issues, and identifies limits and prospects for the free-energy principle as a first principle in the life sciences. (shrink)

We put forward a new, ‘coherentist’ account of quantum entanglement, according to which entangled systems are characterized by symmetric relations of ontological dependence among the component particles. We compare this coherentist viewpoint with the two most popular alternatives currently on offer—structuralism and holism—and argue that it is essentially different from, and preferable to, both. In the course of this article, we point out how coherentism might be extended beyond the case of entanglement and further articulated.

This paper contributes to the debate on online trust addressing the problem of whether an online environment satisfies the necessary conditions for the emergence of trust. The paper defends the thesis that online environments can foster trust, and it does so in three steps. Firstly, the arguments proposed by the detractors of online trust are presented and analysed. Secondly, it is argued that trust can emerge in uncertain and risky environments and that it is possible to trust online identities when (...) they are diachronic and sufficient data are available to assess their reputation. Finally, a definition of trust as a second-order property of first-order relation is endorsed in order to present a new definition of online trust. According to such a definition, online trust is an occurrence of trust that specifically qualifies the relation of communication ongoing among individuals in digital environments. On the basis of this analysis, the paper concludes by arguing that online trust promotes the emergence of social behaviours rewarding honest and transparent communications. (shrink)

The notion of subject matter is a key concern of contemporary philosophy of language and logic. A central task for a theory of subject matter is to characterise the notion of sentential subject matter, that is, to assign to each sentence of a given language a subject matter that may count as its subject matter. In this paper, we elaborate upon David Lewis’ account of subject matter. Lewis’ proposal is simple and elegant but lacks a satisfactory characterisation of sentential subject (...) matter. Drawing on linguistic literature on focus and on the question under discussion, we offer a neo-Lewisian account of subject matter, which retains all the virtues of Lewis’ but also includes an attractive characterisation of sentential subject matter. (shrink)